BookRiekelt H. Houtkooper, editor.
Contents:
1. Biochemistry and enzymology of sirtuins
2. NAD as a pharmacological tool to boost sirtuin activity
3. Protein lysine acylation: abundance, dynamics and function
4. SIRT1 in metabolic health and disease
5. Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function
6. SIRT5 reveals novel enzymatic activities of sirtuins
7. Diverse roles of SIRT6 in mammalian healthspan and logevity
8. Sirtuins in cancer, emerging role as modulators of metabolic reprogramming
9. Sirtuins as metabolic modulators of muscle plasticity
10. Sirtuins and aging
11. Sirtuins and the circadian clock: epigenetic and metabolic crosstalk
12. Sirtuin activation by small molecules
13. Sirtuins: a future perspective
Index.