Books

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  • Digital
    Natarajan Balaji.
    Springer2020
    This textbook addresses the growing need for a manual that teaches when and how to perform nasal tip rhinoplasty through an "Open-Approach". Practitioners will value the comprehensive coverage of the topic. The actual surgical steps involved in the various techniques form the main body of the work, while a wealth of intra-operative photographs facilitate the learning experience. The views expressed are solely those of the author, based on his personal experience. He makes no claims to the content being exhaustive or the only possible approach and has extensively referenced various experts in the field who have contributed to this topic. This book represents the author's view of how to approach nasal tip deformities, and how to arrive at an algorithm in putting together various surgical techniques in a "sequence" to achieve meaningful results. The book also explores the clinical correlation, which is just as or arguably even more important in nasal tip surgery. The main chapters will focus on the suture, grafting, non-suture and non-grafting techniques in nasal tip reconstruction. Drawing on the author's surgical experience, gathered in the course of over 1700 open tip surgeries over 23 years, the book fills a lacuna in teaching and training and will be of interest to all trainees and consultant surgeons seeking concise information on nasal tip surgery.
  • Digital
    edited by Joseph E. Pizzorno and Michael T. Murray.
    ClinicalKey2021
    ClinicalKey Nursing2021
  • Digital
    edited by Ajay K. Singh, Gordon H. Williams.
    ClinicalKey2018
    "Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid-base disturbances, and pregnancy"--Publisher's description.
  • Digital
    edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Gert Kwakkel, Robert Miller.
    Cambridge2014
  • Digital
    edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Gert Kwakkel, Robert Miller.
    Cambridge2014
  • Digital
    Hemanshu Prabhakar, Zulfiqar Ali, editors.
    Springer2019
    This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This first volume focuses on neuroanesthesia. The book begins with basic information on neuroanesthesia, extensively discussing the anatomy of the brain and spine, physiology and relevant pharmacology. Special considerations for pregnant, pediatric and geriatric patients are covered in separate chapters. Each neurosurgical condition is discussed in a standard format relevant for neurosurgical patients, and each chapter, prepared by experts in the field, includes ample illustrations and flowcharts. Information is also provided on the latest evidence-based approaches, robotic surgery and gene therapy. The book offers a valuable resource for all residents, fellows and trainees in the fields of neuroanesthesia and anesthesia; it will also benefit practitioners and consultants. .
  • Digital
    Hemanshu Prabhakar, Zulfiqar Ali, editors.
    Springer2019
    This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This second volume focuses on neurocritical care. The book begins with basic information on the principles of neurocritical care. Management of various neurological problems such as myasthenia gravis, Guillain-Barré syndrome, epilepsy, stroke and many more are discussed in detail. Subsequent sections address nursing care, physiotherapy and psychological care, issues related to brain death and organ donation, and common complications observed in neurological patients during their ICS stays. Each complication is discussed in detail, guiding readers in their clinical practice. In turn, the book's closing chapters cover e.g. the role of hypothermia and evidence-based practice. The book offers a valuable resource for all residents, fellows and trainees in the fields of neurointensive care and critical care; it will also benefit intensivists and neurocritical care experts. .
  • Digital
    A. Joseph Layon, Andrea Gabrielli, William A. Friedman, editors.
    Springer2013
    Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. It takes an appreciation of the logistics of care in these difficult times of imbalance between more and sicker patients and fewer medical specialists. The impact of the right personnel, whose interest and training is in neurocritical care, has shown promise, both in terms of improving patient outcome and quality. The editors have updated this second edition with the latest knowledge and trends. Gathering together a group of international experts who champions the three characteristics Patient and Family Centered High Quality Care, Education, and Discovery needed in our NeuroICUs, the editors present to the reader a comprehensive textbook of neurocritical care, incorporating best practice / evidence-based medicine and performance improvement. This book is not an effort to embellish the shelf of a medical library; it is a practical bedside friend to be used to improve the neurological outcomes of those for whom we are honored to care: our patients.
  • Digital
    edited by Helena Knotkova, Dirk Rasche.
    Springer2015
    Textbook of Neuromodulation encompasses the basic principles, methods and current clinical applications of invasive and non-invasive neuromodulation. Neurophysiological systems are reviewed along with the basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. The overview of the neuromodulatory techniques is provided with special regard to safety and specific patient populations. Comprehensive and authored by leaders in the field, this resource presents the clinical potential, significance and practical applications of this innovative treatment approach.
  • Digital
    Kaveri Chakrabarty, A.S. Chakrabarty.
    Springer2019
    This textbook offers a concise, yet comprehensive account of human nutrition, food and nutrition-related health problems, based on the curricula of top universities around the globe. Nutrition is a multidisciplinary science, and as such, the book discusses various aspects of physiology, biochemistry, pathology, immunology, medicine, food science, and other fields related to nutrition, it focuses on the role of nutrition in the maintenance of health. The various chapters explore highly relevant issues, such as, addiction-related health problems, lifestyle-related disorders, social health problems and poor-maintenance of food hygiene and food safety. It also addresses the role of nutritional therapies for mental disorders, and includes an integrated perspective on cognition, oxidative stress and nutritional interventions in aging. Other topics include, the role of gut microbiota on human health, nutraceuticals as therapeutic agents and ketogenic diets. It also highlights malnutrition (protein energy malnutrition, starvation, malabsorption syndrome, eating disorders and overnutrition/obesity) and adipose tissue as an active endocrine organ. Moreover, it examines key concepts concerning the role of vitamins in the citric acid cycle (gluconeogenesis, ketogenesis, oxidative deamination and transamination) and precursors of coenzymes, as well as calorigenic hormones, appetite-stimulating/appetite-inhibiting hormones, anabolic and catabolic hormones affecting protein metabolism, and lipogenetic/lipolytic hormones.
  • Digital
    Stephen C. Kaufman, Douglas R. Lazzaro, editors.
    Springer2017
    Arranged by ocular anatomy and subspecialty, with a detailed index permitting the reader to locate a discussion involving a specific type of ocular injury, this text covers ocular trauma in the pediatric and adult patient with medical and surgical treatment options, as well as potential complications. The Textbook of Ocular Trauma: Evaluation and Treatment provides a practical reference and educational resource for ophthalmologists, ophthalmology residents, emergency room physicians and residents, and pediatric physicians and residents, with basic and advanced instruction in the evaluation and management of eye and surrounding tissue trauma. This text includes multiple case reports with high quality color photographs after each section, as well as detailed medical illustrations of trauma cases and their treatment. Case studies include both common and unusual types of ocular and surrounding tissue trauma, which provide practical guidance in the evaluation and treatment of eye injuries.
  • Digital
    Rakesh Garg, Sushma Bhatnagar, editors.
    Springer2021
    This book covers all essential evidence on perioperative care and anesthetic concerns for cancer surgeries, including the evaluation and assessment of patients' schedule for cancer surgeries, perioperative anesthetic management of various cancers, perioperative analgesia for cancer surgeries, and issues related to inoperable cancers. It reviews anesthetic considerations of all cancer types as there is a wide variation in anesthetic requirements in this subset of patients. Cancer surgeries are on the rise worldwide and healthcare facilities with cancer as a core specialty are emerging quickly around the globe. As cancer is on rise and efficient surgical management is available, more and more patients are being treated surgically. However, cancer surgeries are complicated, have varied concerns and these are not covered sufficiently in presently available textbooks of anesthesiology. This book fulfills the growing need for complete and comprehensive textbook of onco-anesthesia and fills the gap in the current texts that do not exclusively cover anesthesia for cancer surgeries. This textbook serves as a comprehensive but quick guide for trainee residents/fellows and practicing anesthesiologists, clinicians and surgeons.
  • Digital
    Teresa K. Woodruff, Divya K. Shah, Wendy S. Vitek, editors.
    Springer2019
    Bringing together more than a decade of dedicated investigation and clinical work, this unique textbook is a unified, comprehensive source for oncofertility research and medical practice that is both authoritative and up-to-date. It will serve as the primary oncofertility reference for the various medical disciplines that must be coordinated to provide care for young cancer patients. Moreover, it contains case studies that are prismatic for new entrants into the field. The book is organized around the major themes of the discipline and includes current research, clinical practice, emerging technologies and didactic questions and is divided into six thematic sections: Fertility implications in both oncologic and non-oncologic settings Options for fertility preservation, both male and female Care of the oncofertility patient, including contraception and pregnancy considerations Oncofertility in clinical practice, from setting up a new program to genetic counseling and communication Ethical and legal considerations Advances in the basic science of oncofertility In each chapter, bulleted key learning points and review study questions bookend the text. Six additional sections, comprised exclusively of clinical case studies illustrating the management of both oncologic and non-oncologic conditions, add to the pedagogical value of the text. Timely and utilizing the best current evidence, Textbook of Oncofertility Research and Practice: A Multidisciplinary Approach will be an invaluable resource for students, residents, fellows and professionals in reproductive endocrinology, pediatric endocrinology, adult and pediatric oncology, adult and pediatric urology, breast surgery, radiation oncology and allied professions where iatrogenic treatments or genetic conditions result in infertility. .
  • Digital
    Saman Warnakulasuriya, John S. Greenspan, editors.
    Springer2020
  • Digital
    Roderick Duncan MacLeod, Lieve Van den Block, editors.
    Springer2019
    Springer Live2019-Continuously updated edition
    Textbook of Palliative Care is a comprehensive, clinically relevant and state-of-the art book, aimed at advancing palliative care as a science, a clinical practice and as an art. Palliative care has been part of healthcare for over fifty years but we still find ourselves having to explain its nature and practice to colleagues and to the public in general. Healthcare education and training has been slow to recognize the vital importance of ensuring that all practitioners have a good understanding of what is involved in the care of people with serious or advanced illnesses and their families. However, the science of palliative care is advancing and our understanding concerning many aspects of palliative care is developing rapidly. The book is divided into separate sections for ease of use. Over 100 chapters written by experts in their given fields provide up-to-date information on a wide range of topics of relevance to those providing care towards the end of life no matter what the disease may be. We present a global perspective on contemporary and classic issues in palliative care with authors from a wide range of disciplines involved in this essential aspect of care. The Textbook includes sections addressing aspects such as symptom management and care provision, organization of care in different settings, care in specific disease groups, palliative care emergencies, ethics, public health approaches and research in palliative care. This Textbook will be of value to practitioners in all disciplines and professions where the care of people approaching death is important, specialists as well as non-specialists, in any setting where people with serious advanced illnesses are residing. It is also an important resource for researchers, policy-and decision-makers at national or regional levels. Neither the science nor the art of palliative care will stand still so we aim to keep this Textbook updated as the authors find new evidence and approaches to care.
  • Digital
    Kjetil Søreide, Stefan Stättner, editors.
    Springer2021
    This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients. Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within "pearls and pitfalls" sections. Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice. .
  • Digital
    edited by Liam Donaldson, Walter Ricciardi, Susan Sheridan, Riccardo Tartaglia.
    Springer2021
    Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems. The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.
  • Digital
    Stefano Guandalini, Anil Dhawan, David Branski [d.], editors.
    Springer2016
    Microvillus Inclusion Disease and Tufting Enteropathy -- The Spectrum of Autoimmune Enteropathy -- Congenital Problems of the Gastrointestinal Tract -- Pyloric Stenosis -- Gastrointestinal Problems of the Newborn -- Enteral Nutrition in Preterm Neonates -- Parenteral Nutrition in Premature Infants -- Infectious Esophagitis -- Eosinophilic Esophagitis -- Gastroesophageal Reflux -- Esophageal Achalasia -- Helicobacter Pylori Gastritis and Peptic Ulcer Disease -- Menetrier Disease -- Viral Diarrhea -- Bacterial Infections -- Intestinal Parasites -- Persistent Diarrhea in Children in Developing Countries -- HIV and the Intestine -- Functional Abdominal Pain and Other Functional Gastrointestinal Disorders -- Disorders of Sucking and Swallowing -- Defecation Disorders in Children: Constipation and Functional Fecal Incontinence -- Hirschsprungs Disease and Intestinal Neuronal Dysplasias -- Chronic Intestinal Pseudo-Obstruction in Childhood -- Gastrointestinal and Nutritional Problems in Neurologically Handicapped Children -- Cyclic Vomiting Syndrome -- Food Allergy -- Eosinophilic Gastroenteropathy -- Crohns Disease -- Indeterminate Colitis/Inflammatory Bowel Disease Unclassified (IBD-U) -- Ulcerative Colitis -- Vasculitides Including Henoch Schnlein Purpura -- Lymphonodular Hyperplasia -- Acute Pancreatitis -- Hereditary Pancreatitis and Chronic Pancreatitis in Children -- Fecal Microbial Transplant: For Whom, How, and When -- Congenital Disorders of Intestinal Electrolyte Transport -- Immunodeficiency Disorders Resulting in Malabsorption -- Congenital Disorders of Lipid Transport -- Pancreatic Insufficiency -- Celiac Disease -- Cystic Fibrosis -- Small Intestinal Bacterial Overgrowth -- Short Bowel Syndrome -- MalnutritionA Global Problem -- Probiotics -- Enteral Nutrition -- Parenteral Nutrition in Infants and Children -- Pediatric Intussusception -- Meckels Diverticulum -- Acute Appendicitis -- Gastrointestinal Vascular Anomalies -- Polyps and Other Tumors of the Gastrointestinal Tract -- Normal Liver Anatomy and Introduction to Liver Histology -- Diagnostic Procedures in Pediatric Hepatology -- Infantile Cholestasis: Approach and Diagnostic Algorithm -- Biliary Atresia and Choledochal Malformations -- Congenital Hepatic Fibrosis, Carolis Disease and Other Fibrocystic Liver Diseases -- Familial Intrahepatic Cholestasis -- Alagille Syndrome -- Chronic Viral Hepatitis B and C -- Bacterial, Fungal and Parasitic Infections of the Liver -- Liver Disease in Primary Immunodeficiencies -- Autoimmune Liver Disease -- Inherited Metabolic Disorders and the Liver -- Wilsons Disease -- Nonalcoholic Fatty Liver Disease -- Vascular Disorders of the Liver -- Portal Hypertension in Children -- Liver Tumors in Children -- Acute Liver Failure in Children -- Complications of Cirrhosis in Children -- Nutritional Management of Children with Liver Disease -- Pediatric Liver Transplantation -- Growing up with Liver Disease -- New Horizons in Pediatric Hepatology: A Glimpse of the Future.
  • Digital
    edited by Concezio Di Rocco, Dachling Pang, James T. Rutka.
    Springer Live2019-Continuously updated edition
    This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.
  • Digital
    Concezio Di Rocco, Dachling Pang, James T. Rutka, editors.
    Springer2020
    Springer Nature Living Reference.
    This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.
  • Digital
    [edited by] James T. Cassidy , Ross E. Petty, Ronald M. Laxer, Carol B. Lindsley.
    ScienceDirect2011
    Section 1. Basic concepts -- section 2. Chronic arthritis -- section 3. Systemic connective tissue diseases -- section 4. Systemic vasculitis -- section 5. Arthritis related to infection -- section 6. Systemic disorders with rheumatic manifestations -- section 7. Noninflammatory causes of musculoskeletal pain.
  • Digital
    [edited by] Ross E. Petty, Ronald M. Laxer, Carol B. Lindsley, Lucy Wedderburn.
    ScienceDirect2016
  • Digital
    Ross E. Petty, Ronald M. Laxer, Carol B. Lindsley, Lucy R. Wedderburn, Elizabeth D. Mellins and Robert C. Fuhlbrigge.
    ClinicalKey2021
    Structure and function -- Genetics and pediatric rheumatic diseases -- Mechanistic investigation of pediatric rheumatic diseases -- Inflammation and its mediators -- Adaptive immunity and autoimmunity -- Understanding clinical investigations -- Clinical outcome measures in pediatric rheumatic diseases -- Pain and its assessment -- Imaging in pediatric rheumatic diseases -- Laboratory investigations -- Principles in the management of patients with rheumatic disease -- Global issues in pediatric rheumatology -- Therapeutics : nonbiologics -- Therapeutics : biologics and small molecules -- Nonmedical therapies in pediatric rheumatic diseases -- Juvenile idiopathic arthritis : classification and basic concepts -- Systemic juvenile idiopathic arthritis -- Polyarticular juvenile idiopathic arthritis -- Oligoarticular juvenile idiopathic arthritis -- Enthesitis-related arthritis -- Psoriatic juvenile idiopathic arthritis -- Uveitis in juvenile idiopathic arthritis -- Systemic lupus erythematosus, mixed connective tissue disease, and undifferentiated connective tissue disease -- Antiphospholipid syndrome -- Neonatal lupus erythematosus -- Juvenile dermatomyositis and other inflammatory muscle diseases -- Juvenile systemic sclerosis -- Localized scleroderma and eosinophilic fasciitis -- Sjögren syndrome and immunoglobulin-G disease -- Raynaud phenomenon and vasomotor syndromes -- Inflammatory central nervous system disorders -- Vasculitis and its classification -- Immune complex small-vessel vasculitis : IGA vasculitis (Henoch-Schönlein) and hypersensitivity vasculitis -- Polyarteritis nodosa -- Kawasaki disease -- Antineutrophil cytoplasmic antibody associated vasculitis -- Takayasu arteritis and other vasculitides -- Behçet disease -- Periodic fever syndromes and other inherited autoinflammatory diseases -- Autoinflammatory bone diseases -- Pediatric sarcoidosis -- Macrophage activation syndrome -- Primary immunodeficiencies and rheumatic diseases -- Infectious arthritis and osteomyelitis -- Lyme disease -- Reactive arthritis -- Skeletal malignancies and related disorders -- The impact of rheumatic diseases and their treatment on bone strength development in childhood -- Skeletal dysplasias -- Noninflammatory musculoskeletal pain -- Musculoskeletal manifestations of inflammatory bowel disease -- Musculoskeletal manifestations of systemic disease -- Pain amplification syndromes -- Primary disorders of connective tissue.
  • Digital
    Asif Muneer, Manit Arya, Simon Horenblas, editors.
    Springer2012
  • Digital
    Kewal K. Jain.
    Springer2009
    Basics of Personalized Medicine -- Molecular Diagnostics as Basis of Personalized Medicine -- Role of Biomarkers in Personalized Medicine -- Pharmacogenetics -- Pharmacogenomics -- Role of Pharmacoproteomics -- Role of Metabolomics in Personalized Medicine -- Personalized Biological Therapies -- Development of Personalized Medicine -- Personalized Therapy for Cancer -- Personalized Management of Neurological Disorders -- Personalized Therapy of Cardiovascular Diseases -- Personalized Management of Miscellaneous Disorders -- Personalized Preventive Medicine -- Organization of Personalized Medicine -- Ethical and Regulatory Aspects of Personalized Medicine -- Economics of Personalized Medicine -- Future of Personalized Medicine.
  • Digital
    by Kewal K. Jain.
    Springer2021
    This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.
  • Digital
    Mark H. Swartz.
    ClinicalKey2021
    Derive the maximum diagnostic information from interviewing and examining patients with Textbook of Physical Diagnosis. Employing a compassionate, humanistic approach, Dr. Swartz explores how cultural differences can influence communication, diet, family relationships, and health practices and beliefs, and demonstrates that your interpersonal awareness is just as essential in physical diagnosis as your level of technical skill. This medical reference book features numerous high-quality color images, an easy-to-use design, and detailed descriptions of exam techniq.
  • Digital
    edited by Deepak M. Kalaskar, Peter E. Butler, Shadi Ghali.
    JSTOR2016
    Section 1: General. Principles of plastic surgery, wound healing, skin grafts and flaps / George Adigbli, Feras Alshomer, Jekaterina Maksimcuka and Shadi Ghali -- Abdominal wall reconstruction / Ali Alhamdi and Shadi Ghali -- Section 2: Cancer. Skin cancer for the plastic surgeon / Sophia Opel and Shadi Ghali -- Oral and oropharyngeal cancer / Jatinder T. Virdee and Nicholas Kalavrezos -- Section 3: Burns and trauma. Burns / Sebastian Salinas, Salman Mofti and Naime Moimen -- Burn reconstructive surgery / Barinder Takhar, Ahmad B. Al-Ali and Naime Moimen -- Soft tissue injuries of the hand / Hiba Khan and Bran Sivakumar -- Lower limb trauma and reconstruction / Rebecca Nicholas, Ayyaz Quddus and Jon Simmons -- Injuries of the facial skeleton / Tom W. Andrew and Nicholas Kalaverozos -- Section 4: Paediatric plastic surgery. Congenital hand abnormalities / Benjamin Way and Bran Sivakumar -- Ear reconstruction / Aurora Almadori, Abdulaziz Khurshed, Ali Jafar, Ahmad B. Al-Ali and Peter E. Butler -- Craniofacial surgery: craniosynostosis syndromes and cleft lip and palate / Ahmed Al-Hadad and Shafiq Rahman -- Genital reconstruction / Shomari Zack-Williams, Debbie Hunt, Asif Muneer and Sarah Creighton -- Vascular anomalies / Wenceslao M. Calonge, Juan Carlos López-Gutiérrez and Neil Bulstrode -- Section 5: Aesthetic surgery. Liposuction / Nina Oliver, Omar Khan Pathan and Ash Mosahebi -- Facial aesthetic surgery / Muholan Kanapathy and Niall Kirkpatrick -- Blepharoplasty -- special focus on Asian blepharoplasty / Billy Ching Leung, Kimberley Lau and Hugo Henderson -- Aesthetic breast surgery / Log Murugesan, Julia Ruston and Patrick Mallucci -- Body contouring / Zain Bukamal and Ash Mosahebi -- The evolution of hair transplant surgery / Farhana Akter and Greg Williams.
  • Digital
    edited by David Buckley, Paola Pasquali.
    Springer2021
    This textbook provides a comprehensive, practical guide to the identification of a range of common dermatological conditions encountered within primary care. It features a problem-based approach to the topics and conditions covered. Clinical photographs, diagrams and pertinent tables along with clear learning objectives, clinical pearls and pitfalls in each chapter facilitate understanding in the diagnosis and management of a range of common dermatological conditions. Textbook of Primary Care Dermatology empowers the reader to develop their understanding of how to deal with a range of common skin, hair and nail problems. It is ideal for training and practising primary care physicians seeking a quick reference guide to use in their clinical practice and the trainee dermatologist seeking a primer on the topic. It is also suitable for other members of the primary care team including nurses, pharmacists, physician associates and clinical assistants, and it is very useful for hospital-based doctors and nurses in other disciplines who want a quick, practical reference to common dermatological problems.
  • Digital
    edited by Alan F. Schatzberg, Charles B. Nemeroff.
    PsychiatryOnline2017
    "The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs -- either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions -- from depression to chronic pain -- as well as for specific populations and circumstances -- from children and adolescents to psychiatric emergencies -- offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response. The book's beneficial features are many: * The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology.* History and discovery, structure--activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug--drug interactions are addressed for each agent. This consistent structure places the desired information at the clinician's fingertips and facilitates study for trainees.* Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine).* More than 180 tables and graphs present critically important data in an accessible way. A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders."--Publisher's description.
  • Digital
    edited by Glen O. Gabbard ; contributors, Jon G. Allen ... [et al.].
    PsychiatryOnline2009
    Theoretical models of psychodynamic psychotherapy -- Techniques of psychodynamic psychotherapy -- Techniques of brief psychodynamic psychotherapy -- Applications of psychodynamic psychotherapy to specific disorders : efficacy and indications -- Combining psychodynamic psychotherapy with medication -- Theory of cognitive therapy -- Techniques of cognitive-behavioral therapy -- Applications of individual cognitive-behavioral therapy to specific disorders : efficacy and indications -- Combining cognitive-behavioral therapy with medication -- Theory of interpersonal psychotherapy -- Techniques of individual interpersonal psychotherapy -- Applications of individual interpersonal psychotherapy to specific disorders : efficacy and indications -- Combining interpersonal psychotherapy with medication -- Theory of supportive psychotherapy -- Techniques of individual supportive psychotherapy -- Applications of individual supportive psychotherapy to psychiatric disorders : efficacy and indications -- Combining supportive psychotherapy with medication -- Family systems theory and practice -- Couples therapy -- Emotionally focused couples therapy : an attachment-based treatment -- Psychodynamic couples therapy : an object relations approach -- Behavioral couples therapy -- Psychodynamic group therapy -- Family intervention for psychotic and severe mood disorders -- Group cognitive-behavioral therapy for chronic pain -- Theory and practice of psychotherapy integration -- Theory and practice of dialectical behavioral therapy -- Theory and practice of mentalization-based therapy -- Brain processes informing psychotherapy -- Professional boundaries in psychotherapy.
  • Digital
    Jason X.-J. Yuan, Joe G.N. Garcia, Charles A. Hales, Stuart Rich, Stephen L. Archer, John B. West.
    Springer2011
  • Digital
    Michael A. DeVita, Ken Hillman, Rinaldo Bellomo, editors.
    Springer2011
    Rapid response systems history and terminology -- RR's general principles -- Measuring and improving safety -- Integrating a rapid response system into a patient safety program -- Acute hospitalist medicine and the rapid response system -- Medical trainees and patient safety -- Rapid response systems: a review of the evidence -- Healthcare systems and their (lack of) integration -- Creating process and policy change in healthcare -- The challenge of predicting in-hospital cardiac arrests and deaths -- The meaning of vital signs -- Matching illness severity with level of care -- Causes of failure to rescue -- Impact of hospital size and location on feasibility of RRS -- Barriers to the implementation of RRS -- An overview of the afferent limb -- The impact of delayed RRS activation -- The case for family activation of the RRS -- RRT: nurse-led RRSs -- MET: physician-led RRSs -- Pediatric RRSs -- Sepsis response team -- Other efferent limb teams: (BAT, DAT, M, H, and trauma) -- Other efferent limb teams: crisis response for obstetric patients -- Personnel resources for responding teams -- Equipment, medications, and supplies for an RRS -- The administrative limb -- The second victim -- RRSs in teaching hospitals -- The nurse's view of RRS -- Resident training and RRSs -- Optimizing RRSs through simulation -- Evaluating effectiveness of complex system interventions -- RRS education for ward staff -- Standardized process and outcome assessment tool -- The impact of RRSs on choosing "not-for-resuscitation" status -- The costs and savings.
  • Digital
    Michael A. DeVita, Ken Hillman, Rinaldo Bellomo, editors ; Mandy Odell, Daryl A. Jones, Bradford D. Winters, Geoffrey K. Lighthall, associate editors.
    Springer2017
  • Digital
    Luigi P. Badano, Roberto M. Lang, José Luis Zamorano (Editors).
    Springer2011
    The evolution of three-dimensional echocardiography: how did it happen -- Technical principles of transthoracic three-dimensional echocardiography -- 3D transesophageal echocardiographic technologies -- Three-dimensional echocardiography in clinical practice -- Advanced evaluation of LV functions with 3D echocardiography -- Three-dimensional echocardiographic evaluation of the mitral valve -- Three-dimensional echocardiographic evaluation of LV dyssynchrony and stress testing -- Three-dimensional echocardiography of aortic valve -- Three-dimensional echocardiographic evaluation of the right ventricle -- Three-dimensional echocardiography in congenital heart disease -- Three-dimensional echocardiography to assess intra-cardiac masses -- Real time three dimensional transesophageal echocardiography for guidance of catheter based interventions -- Future developments of three-dimensional echocardiography -- Real time three-dimensional transesophageal echocardiography -- The role of echocardiography in the surgical management of degenerative mitral valve disease -- Visualization and assessment of coronary arteries with three-dimensional echocardiography -- Assessment of tricuspid valve morphology and function -- Role of three-dimensional echocardiography in drug trials.
  • Digital
    Ronald R. Krueger, Jonathan H. Talamo, Richard L. Lindstrom, editors.
    Springer2013
    Evolution of Cataract Surgery -- Current Outcomes with Cataract Surgery: Can We Do Better? -- Femtosecond Laser Fundamentals -- Challenges of Femtosecond Laser Technologies for Cataract Surgery -- Imaging Systems and Image-Guided Surgery -- The Patient Interface: Setting the Stage for Treatment -- Laser Capsulotomy -- Nucleus Fragmentation and Disassembly in ReLACS -- Primary Transcorneal Laser Incisions -- Relaxing Incisions for Astigmatism Correction in ReLACS -- Femtosecond Laser Versus Phacoemulsification -- Economics of ReLACS: Marketing a New Technology to Your Patients -- Step-By-Step: Starting Your ReLACS Practice -- Global Implications of Refractive Laser Assisted Cataract Surgery (ReLACS) -- Commercially Available Systems: Alcon/LenSx -- Commercially Available Systems: LensAR Laser System -- Commercially Available Systems: OptiMedica's Catalys Precision Laser System -- Commercially Available Systems: The TECHNOLAS Femto-Cataract Approach -- The Future of ReLACS and Femtosecond Laser Ocular Surgery.
  • Digital
    Ian A. Trail [and three others], editors.
    Springer2019
    This textbook provides the most up-to-date information on shoulder surgery along with practical approaches for patient evaluation and treatments options. The book is divided into key sections, providing coverage on Soft Tissue Disorders of the Shoulder, Arthritis of the Shoulder, The Paediatric Shoulder and other miscellaneous topics relevant to treating this area. Its strong clinical focus will help residents and medical students to manage patients in a practical way, based on the most recent scientific evidence and the most effective surgical and non-surgical techniques. Thus, it will become a valuable reference and resource for young doctors and students looking to increase their professional skills and knowledge when treating shoulder injuries and disorders in clinical practice. .
  • Digital
    editors in chief, Keith H. Bridwell, Ronald L. DeWald ; associate editors, Peter D. Angevine [and others] ; managing editor for Dr. Bridwell, Theresa M. Iffrig.
    LWW Health Library2011
    General considerations -- Biomechanics -- Anatomic approaches -- The cervical degenerative spine -- The thoracic and lumbar degenerative spine -- Spondylolisthesis -- Idiopathic scoliosis -- Adult spinal deformity -- Dysplastic and congenital deformities -- Paralytic deformity -- Kyphosis and postlaminectomy deformities -- Trauma -- Tumor and osteomyelitis -- Complications.
  • Digital
    Axel Pressler, Josef Niebauer, editors.
    Springer2020
    This textbook provides a comprehensive, yet practically orientated overview of classic and novel sports cardiology topics, based on current evidence, guidelines, recommendations and expert experience. Numerous publications have provided guidance to these issues, but it has become increasingly difficult for both students and doctors to obtain a thorough, but practicable overview for optimal clinical care of athletes and patients. This book is intended as an educational work, filling the large gaps that are still present in the current educational guidelines for medical students and cardiology trainees. Textbook of Sports and Exercise Cardiology differs from other sports cardiology books by focusing on clear, practical recommendations based on the latest evidence, primarily targeting those who seek professional background information and education that can easily be transferred into everyday care.
  • Digital
    Andres M. Lozano, Philip L. Gildenberg, Ronald R. Tasker (eds.).
    Springer2009
  • Digital
    edited by Michael Brainin, MD, PhD, Professor and Chair, Department of Clinical Neuroscience and Preventive Medicine, Danube University Krems, Krems, Austria, Wolf-Dieter Heiss, MD, PhD, Professor of Neurology, Emeritus Director, Max Planck Institute for Neurological Research and Department of Neurology, University of Cologne, Cologne, Germany ; editorial assistant, Susanne Tabernig, MD, Vienna, Austria.
    Cambridge2014
    Neuropathology and pathophysiology of stroke / Konstantin A. Hossmann and Wolf-Dieter Heiss -- Common causes of ischemic stroke / Bo Norrving -- Neuroradiology / Jochen B. Fiebach, Patrik Michel, and Jens Fiehler -- Imaging for prediction of functional outcome and for assessment of recovery / Wolf-Dieter Heiss -- Ultrasound in acute ischemic stroke -- Basic epidemiology of stroke and risk assessment / Jaako Tuomilehto -- Common risk factors and prevention / Michael Brainin, Yvonne Teuschl, and Karl Matz -- Cardiac diseases relevant to stroke / Claudia St llberger and Josef Finsterer -- Common stroke syndromes / line Odier and Patrik Michel -- Less common stroke syndromes / Wilfried Lang -- Intracerebral hemorrhage / Corina Epple, Michael Brainin, and Thorsten Steiner -- Subarachnoid hemorrhage / Philip Lichti and Thorsten Steiner -- Cerebral venous thrombosis / Jobst Rudolf -- Behavioral neurology of stroke / Jose M. Ferro, Isabel P. Martins, and Lara Caeiro -- Stroke and dementia / Barbara Casolla and Didier Leys -- Ischemic stroke in the young and in children / Valeria Caso and Didier Leys -- Stroke units and clinical assessment / Danilo Toni and ngel Chamorro -- Acute therapies for stroke / Richard E. O'Brien and Kennedy R. Lees -- Interventional intravascular therapies for stroke / Pasquale Mordasini, Jan Gralla, and Gerhard Schroth -- Management of acute ischemic stroke and its late complications / Natan M. Bornstein and Eitan Auriel -- Infections in stroke / Achim Kaasch and Harald Seifert -- Secondary prevention / Hans-Christoph Diener, Sharan K. Mann, and Gregory W. Albers -- Neurorehabilitation practice for stroke patients / Sylvan J. Albert and Jorg Kesselring.
  • Digital
    edited by Michael Brainin, Wolf-Dieter Heiss.
    Cambridge2019
    Concise and informative, this guide is for doctors preparing to specialise in stroke care and strokologists looking for rapid but in-depth scientific guidance on stroke management. This third edition is fully revised to ensure that medical professionals are completely up-to-date in this fast-moving field. Its practical and problem-based approach covers all important issues of prevention, diagnosis, and treatment of cerebrovascular diseases, and reviews epidemiology and risk assessment. This new edition features expanded sections on topics of stroke unit management, thrombolysis, neurointerventions, cognitive impairment, secondary prevention and rehabilitation, and includes new chapters on neurointensive care and small vessel disease. Comprehensive in its coverage, the textbook includes acute assessment, imaging and emergency interventions. The authors are renowned experts in their field and have been working together in a teaching faculty for the European Master in Stroke Medicine Programme, which is supported by the European Stroke Organisation and the World Stroke Organisation.
  • Digital
    [edited by] Francis H. Shen, Dino Samartzis, Richard G. Fessler.
    ClinicalKey2015
    Cervical spine anatomy -- Approaches to the upper cervical spine -- Anterior surgical approach to the cervical spine -- Posterior surgical approach to the cervical spine -- Anterior approaches and surgical considerations for pathology of the cervicothoracic junction -- Developmental and congenital disorders of the cervical spine -- Biomechanics of the cervical spine -- Evaluation of the cervical spine -- Radiographic and computed tomography evaluation of the cervical spine -- Magnetic resonance imaging of the cervical spine -- Neurophysiologic monitoring of the cervical spine -- Cervical degenerative disk disease -- Cervical radiculopathy -- Cervical spondylotic myelopathy -- Cervical deformity and treatment algorithms -- Ossification of the posterior longitudinal ligament -- Occipitocervical and upper cervical spine fractures -- Subaxial cervical spine injuries -- Spinal cord injuries and syndromes -- Traumatic arterial injuries : diagnosis and management -- Stingers and transient paresis -- Primary tumors of the spinal cord -- Primary bony tumors of the cervical spine -- Metastatic disease of the cervical spine -- Infections of the cervical spine -- Tuberculosis of the cervical spine -- Rheumatoid arthritis of the cervical spine -- Ankylosing spondylitis of the cervical spine -- Syringomyelia -- Anterior cervical diskectomy and fusion -- Anterior cervical corpectomy and fusion and hybrid techniques -- Cervical disk arthroplasty -- Anterior cervical foraminotomy -- Laminectomy and fusion -- Cervical laminoplasty -- Posterior cervical endoscopic laminoforaminotomy -- Osteotomies of the cervical spine -- Occipitocervical fixation -- C1 lateral mass and C2 pedicle screw fixation -- C1-C2 transarticular screws -- C2 translaminar screw fixation -- Cervical pedicle screws -- Lateral mass screws -- Interspinous wiring -- Minimally invasive techniques in the cervical spine -- Image-guided navigation for cervical spine surgery -- Biologics for intervertebral disk regeneration and repair -- Biologics for spinal fusion -- Intervertebral disk transplantation -- Vascular injuries -- Spinal cord and nerve injuries in the cervical spine -- Tracheoesophageal injuries -- Dural tear -- Wound complications -- Adjacent segment disease -- Nonunions and implant failures of the cervical spine.
  • Digital
    Luigi P. Badano, Roberto M. Lang, Denisa Muraru, editors.
    Springer2019
  • Digital
    Aage R. Møller, Berthold Langguth, Dirk De Ridder, Tobias Kleinjung, editors.
    Springer2011
  • Digital
    edited by Jonathan M. Silver, Thomas W. McAllister, Stuart C. Yudofsky.
    PsychiatryOnline2011
    As soldiers and combat veterans have returned from the wars in Iraq and Afghanistan traumatic brain injury (TBI) has been identified as the "signature injury" of those wars. TBI is also in the news on a daily basis due to sports injuries. This new edition has been revised and updated from the 2005 first edition to reflect the exponential expansion of research and clinical data amassed in the intervening years. Each chapter was written and reviewed by the foremost authorities in neuropsychiatry, neurology, rehabilitation medicine, and the other specialties who assess, diagnose, and treat these patients. The revisions and additions to this comprehensive volume were made to ensure that the scope and coverage is both up-to-date and down-to-earth. Key features include: New chapters on epidemiology, neuropathology, and genetics of TBI; new chapter on TBI in the military emphasizing the unique feature of blast injury; A new chapter on posttraumatic stress disorder (PTSD), which emphasizes the common co-occurrence of TBI and PTSD in both combat and other settings; Enhanced coverage of psychopharmacology and psychotherapy for the psychiatric symptoms associated with TBI; Information on the social ramifications of TBI so that clinicians will better understand and help their patients cope with the complex legal, financial, and insurance-based struggles their patients who have sustained TBI encounter; Each chapter concludes with essential points and key references to focus attention and consolidate learning; A foreword written by Bob Woodruff (the ABC World News correspondent who sustained a TBI while covering the war in Iraq) and his wife, Lee Woodruff, who underscore that although this volume is intended to be read primarily by professionals, patients and families may also find the information in the textbook to be of keen interest and practical application.
  • Digital
    edited by Jonathan M. Silver, Thomas W. McAllister, David B. Arciniegas.
    PsychiatryOnline2019
    Part I: Epidemiology and pathophysiology -- Part II: Assessment -- Part III: Neuropsychiatric aspects of traumatic brain injury -- Cognition -- Emotion -- Behavior -- Somatic -- Part IV: Speical populations and issues -- Mild brain injury -- Other populations -- Part V: Treatment.
  • Digital
    edited by Derek Raghavan [and six others].
    Wiley2017
  • Digital
    Rhian M. Touyz, Christian Delles, editors.
    Springer2019
    This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies. -- Provided by publisher.
  • Print
    by A.J. Rhodes and C.E. van Rooyen.
  • Digital
    Luc Téot, Thomas A. Mustoe, Esther Middelkoop, Gerd G. Gauglitz, editors.
    Springer2021
    This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment - a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners.
  • Digital
    Aristidis Moustakas, Keiji Miyazawa, editors.
    Springer2013
  • Digital
    edited by Xin-Hua Feng, Pinglong Xu, Xia Lin.
    Springer2016
    Regulation of TGF-beta receptors / Erine H. Budi, Jian Xu, and Rik Derynck -- 2 Determining TGF-beta receptor levels in the cell membrane / Long Zhang ... [et al.] -- Posttranslational modifications of TGF-beta receptors / Xiaohua Yan and Ye-Guang Chen -- Production, isolation, and structural analysis of ligands and receptors of the TGF-beta superfamily / Tao Huang and Andrew P. Hinck -- Phosphorylation of Smads by intracellular kinases / Fang Liu and Isao Matsuura -- Analysis of Smad phosphatase activity in vitro / Tao Shen, Lan Qin, and Xia Lin -- Three-dimensional mammary epithelial cell morphogenesis model for analysis of TGFbeta signaling / Juliet Rashidian and Kunxin Luo -- TGF-beta signaling in stem cell regulation / Wenlin Li, Wanguo Wei, and Sheng Ding -- Analysis of epithelial-mesenchymal transition induced by transforming growth factor beta / Ulrich Valcourt ... [et al.] -- In vitro Th differentiation protocol / Takashi Sekiya and Akihiko Yoshimura -- Interrogating TGF-beta function and regulation in endothelial cells / J. A. Maring ... [et al.] -- Isolation and manipulation of adipogenic cells to assess TGF-beta superfamily functions / Maria Namwanje, Juan C. Bournat, and Chester W. Brown -- Imaging TGF-beta signaling in mouse models of cancer metastasis / Yibin Kang -- Generation and characterization of Smad7 conditional knockout mice / Yi Pan and Yan Chen -- Monitoring Smad activity in vivo using the Xenopus model system / Marco Montagner, Graziano Martello, and Stefano Piccolo -- Animal cap assay for TGF-beta signaling / Chenbei Chang -- Detection of Smad signaling in Zebrafish embryos / Xingfeng Liu, Qiang Wang, and Anming Meng -- Role of TGF-beta signaling in coupling bone remodeling / Janet L. Crane, Lingling Xian, and Xu Cao -- Studying the functions of TGF-beta signaling in the ovary / Chao Yu, Jian-Jie Zhou, and Heng-Yu Fan -- Quantitative real-time PCR analysis of MicroRNAs and their precursors regulated by TGF-beta signaling / Hara Kang and Akiko Hata -- TGF-beta-regulated MicroRNAs and their function in cancer biology / Pengyuan Yang ... [et al.] -- Epigenomic regulation of Smad1 signaling during cellular senescence induced by Ras activation / Atsushi Kaneda ... [et al.] -- Role of ubiquitination to Determine non-Smad signaling responses / Shyam Kumar Gudey and Marene Landström -- Genome-wide RNAi screening to dissect the TGF-beta signal transduction pathway / Xiaochu Chen and Lan Xu -- Measuring TGF-beta ligand dynamics in culture medium / Zipei Feng , Zhike Zi , and Xuedong Liu.
  • Digital/Print
    Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors.
    Digital : Springer2009
    Print2009
  • Digital
    edited by Ritobrata Goswami.
    Springer2017
    This volume presents comprehensive laboratory protocols that have been used to generate Th9 cells, both in vitro and in vivo. The techniques described in Th9 Cells: Methods and Protocols study the role of Th9 cells in different inflammatory disease models, including allergic inflammation model, parasite model, tumor model, and EAE and IBD model. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and comprehensive, Th9 Cells: Methods and Protocols is a valuable resource for scientists in this field and will provide them with techniques to generate Th9 cells for specific downstream events.
  • Digital
    Shiuping Jiang, editor.
    Springer2011
  • Print
    Douglas Stone & Sheila Heen.
    Drawing on ten years of working with businesses, nonprofits, governments, and families, the authors combine the latest insights from neuroscience and psychology with practical advice to explain how to turn feedback into productive listening and learning. "The bestselling authors of the classic Difficult Conversations teach us how to turn evaluations, advice, criticisms, and coaching into productive listening and learning We swim in an ocean of feedback. Bosses, colleagues, customers-but also family, friends, and in-laws-they all have "suggestions" for our performance, parenting, or appearance. We know that feedback is essential for healthy relationships and professional development-but we dread it and often dismiss it. That's because receiving feedback sits at the junction of two conflicting human desires. We do want to learn and grow. And we also want to be accepted just as we are right now. Thanks for the Feedback is the first book to address this tension head on. It explains why getting feedback is so crucial yet so challenging, and offers a powerful framework to help us take on life's blizzard of off-hand comments, annual evaluations, and unsolicited advice with curiosity and grace. The business world spends billions of dollars and millions of hours each year teaching people how to give feedback more effectively. Stone and Heen argue that we've got it backwards and show us why the smart money is on educating receivers- in the workplace and in personal relationships as well. Coauthors of the international bestseller Difficult Conversations, Stone and Heen have spent the last ten years working with businesses, nonprofits, governments, and families to determine what helps us learn and what gets in our way. With humor and clarity, they blend the latest insights from neuroscience and psychology with practical, hard-headed advice. The book is destined to become a classic in the world of leadership, organizational behavior, and education"-- Provided by publisher.
  • Digital
    NCBI Bookshelf2017
  • Digital
    [edited by] Arun C. Gulani.
    Thieme MedOne Ophthalmology2019
    Pterygium : history and overview / Arun C. Gulani and Parth G. Patel -- Classic signs, symptoms, classification, and differential diagnosis of pterygium / Sotiria Palioura and Eduardo Alfonso -- Current concepts in treatments of pterygium : an evidence-based review / Nathan Rock, Ming Wang, Nancy Argano, and Ilan Cohen -- Evolution of the medical and surgical treatments for pterygium / Ahmed A. Abdelghany and Jorge L. Alio -- Ocular surface and tear film management in pterygium surgery / Alanna S. Nattis, Henry D. Perry, and Eric D. Donnenfeld -- Amniotic membrane and umbilical cord as platform technology to promote regenerative healing / Anny M.S. Cheng and Scheffer C.G. Tseng -- Conjunctival autograft for primary and recurrent pterygium : past, present, and future / Minas T. Coroneo -- Amniotic graft surgery in ocular surface pathologies besides pterygium / Arun C. Gulani -- Mitomycin C, glues, sealants, and ancillaries in pterygium surgery / Arun C. Gulani, and Sonal Tuli -- Nonsurgical management of irregular astigmatism associated with pterygium / Melissa Barnett, Thomas P. Arnold, Nathan Schramm, Andrew Morgenstein, Christine Sindt, and Tracy Schroeder Swartz -- Stem cell applications in pterygium / Abhinav Loomba and Virender Singh Sangwan -- Surgical approach to isolated and associated presentations of pterygium / Alan N. Carlson -- Complications of pterygium surgery / Dhivya Ashok Kumar, Soosan Jacob, Ashvin Agarwal, and Amar Agarwal -- Complex pterygium surgery and complication management to cosmetic endpoints / Arun C. Gulani and Aaishwariya A. Gulani -- Pterygium and pinguecula surgery : next-day cosmetic outcomes / Arun C. Gulani and Aaishwariya A. Gulani -- Kerato-refractive and premium cataract surgery with pterygium / Arun C. Gulani.
  • Print
    Roberts, Laura Weiss.
  • Print
    Kelsky, Karen.
  • Print
    Zora Neale Hurston ; with a foreword by Edwidge Danticat and an afterword by Henry Louis Gates, Jr.
    A novel about black Americans in Florida that centers on the life of Janie and her three marriages.
  • Digital
    Nilmini Wickramasinghe, Jonathan L. Schaffer, editors.
    Springer2018
    "This unifying volume offers a clear theoretical framework for the research shaping the emerging direction of informatics in health care. Contributors ground the reader in the basics of informatics methodology and design, including creating salient research questions, and explore the human dimensions of informatics in studies detailing how patients perceive, respond to, and use health data. Real-world examples bridge the theoretical and the practical as knowledge management-based solutions are applied to pervasive issues in information technologies and service delivery. Together, these articles illustrate the scope of health possibilities for informatics, from patient care management to hospital administration, from improving patient satisfaction to expanding the parameters of practice. Highlights of the coverage: · Design science research opportunities in health care · IS/IT governance in health care: an integrative model · Persuasive technologies and behavior modification through technology: design of a mobile application for behavior change · The development of a hospital secure messaging and communication platform: a conceptualization · The development of intelligent patient-centric systems for health care · An investigation on integrating Eastern and Western medicine with informatics Interest in Theories to Inform Superior Health Informatics Research and Practice cuts across academia and the healthcare industry. Its audience includes healthcare professionals, physicians and other clinicians, practicing informaticians, hospital administrators, IT departments, managers, and management consultants, as well as scholars, researchers, and students in health informatics and public health"--Back cover.
  • Digital
    Shiyi Shen, Jack A. Tuszynski.
    Springer2008
  • Print
    Cazeaux, P.; Hess, Robert J.; Tarnier, S.
  • Digital
    [edited by] Jack Ende.
    R2Library2010Limited to 1 simultaneous user
    Medical teaching--formal and informal, preclinical and clinical, planned and impromptu--is complex. Physician-teachers must be concerned with meeting the needs of the learner while providing effective care for the patient. Offering the insight and experience of dedicated medical educators, Theory and Practice of Medicine includes: Practical applications of learning theories to better meet learners' needs. Characteristics of successful medical teachers. Approaches to developing faculty and improving clinical teaching. Vignettes addressing specific clinical teaching challenges. Resources and literature for medical teachers to enhance their knowledge. A special section, "Memorable Moments in Teaching and Learning," shares poignant anecdotes and personal stories of the power, joy, and humanity of teaching medicine from 22 colleagues in the field of internal medicine.
  • Digital
    Richard P. Baum, Frank Rösch, editors.
    Springer2013
  • Digital
    Ganji Seeta Rama Raju, L.V.K.S. Bhaskar, editors.
    Springer2020
    This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer. -- Provided by publisher.
  • Digital
    edited by Liron D. Sinvani.
    Ovid2020
  • Digital
    Yukihito Higashi, Toyoaki Murohara, editors.
    Springer2017
    The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.
  • Digital
    Mark Slevin, editor.
    Springer2011
  • Digital
    Yuti Chernajovsky, Ahuva Nissim, editors.
    Springer2008
  • Digital
    William R. Strohl and Lila M. Strohl.
    ScienceDirect2012
  • Digital/Print
    edited by José Luis Pedraz, Gorka Orive.
    Digital : Springer2010
    Print2010
    Highlights and trends in cell encapsulation / Gorka Orive and José Luis Pedraz -- Biomaterials in cell microencapsulation / Edorta Santos ... [et al.] -- Development of subsieve size capsules and application to cell therapy / Shinji Sakai and Koei Kawakami -- Regulatory considerations in application of encapsulated cell therapies / J. van Zanten and Paul de Vos -- Treatment of diabetes with encapsulated islets / Paul de Vos, Milica Spasojevic, and Marijke M. Faas -- Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules / Ainhoa Murua ... [et al.] -- Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering, and cell therapy / Zun Chang Liu and Thomas Ming Swi Chang -- Microencapsulated choroid plexus epithelial cell transplants for repair of the brain / Christopher G. Thanos, Briannan Bintz, and Dwaine F. Emerich -- Therapeutic application of cell microencapsulation in cancer / Brian Salmons and Walter H. Gunzburg -- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery / Adam Mendelsohn and Tejal Desai -- Cell microencapsulation / Grace J. Lim ... [et al.] -- Commercial applicability of cell microancapsulation : a review of intellectual property rights / Stephan M. Meier.
  • Digital
    Stephen Neidle.
    ScienceDirect2012
    "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. 4 of cover.
  • Digital
    edited by Daniel Lafontaine and Audrey Dubé, Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
    Springer2014
    Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites -- Screening inhibitory potential of anti-HIV RT RNA aptamers -- Design and evaluation of clinically relevant SOFA-HDV ribozymes targeting HIV RNA -- Directing RNase P-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells -- Design and analysis of hammerhead ribozyme activity against an artificial gene target -- Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells -- Use of tumor-targeting trans-splicing ribozyme for cancer treatment -- Characterization of hairpin ribozyme reactions -- Finding instances of riboswitches and ribozymes by homology search of structured RNA with infernal -- Structure-based virtual screening for the identification of RNA- binding ligands -- Probing riboswitch binding sites with molecular docking, focused libraries, and in-line probing assays -- Discovery of small molecule modifiers of micrornas for the treatment of HCV infection -- Bacterial flavin mononucleotide riboswitches as targets for flavin analogs -- Construction and application of riboswitch-based sensors that detect metabolites within bacterial cells -- Screening assays to identify artificial glmS ribozyme activators -- Analysis of riboswitch structure and ligand binding using small-angle X-ray scattering (SAXS) -- Use of SHAPE to select 2AP substitution sites for RNA-ligand interactions and dynamics studies -- Cell internalization SELEX: In vitro selection for molecules that internalize into cells -- DNA electronic switches based on analyte-responsive aptamers.
  • Digital
    edited by Amitava Dasgupta.
    ScienceDirect2012
    ClinicalKey2012
    Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presentsssnew and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathol.
  • Digital
    Kiron Varghese, Srilakshmi Adhyapak.
    Springer2017
    Overview of the indications for embolizations -- Materials used for embolization -- Bronchial artery embolization for massive hemoptysis -- Renal artery embolization for bleeding, hemangiomas, renal cell carcinoma -- Splenic artery embolization for non-surgical splenectomy -- Embolization of arterio-venous malformations -- Uterine artery embolization for intractable menorrhagia.
  • Digital
    Evangelos Kalaitzakis, Peter Vilmann, Manoop S. Bhutani, editors.
    Springer2020
    This book provides an up-to-date review of therapeutic EUS with an equal focus on technical descriptions with ample endoscopic images/video clips by world experts and the scientific evidence behind the described techniques. The book provides an overview of the field in a structured manner, starting with general topics on equipment and service development and extending to the fields of EUS-guided drainage, anti-tumor therapies, and other specific EUS-guided interventional treatments. Therapeutic Endoscopic Ultrasound is a key resource for endoscopists, gastroenterologists, surgeons, and GI oncologists.
  • Digital
    Nikolaos Labrou, editor.
    Springer2019
    This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This book covers mainly three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology: (i) overview of the production process and biochemical characterization of therapeutic enzymes, (ii) focuses upon the engineering strategies and delivery methods of therapeutic enzymes, (iii) clinical applications of selected therapeutic enzymes, including aspects on their mechanisms of action and information on safety, immunogenicity issues and various adverse events of the enzymes used for therapy. The topic of this book is particularly relevant to academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
  • Digital
    Hoon Jai Chun, Suk-Kyun Yang, Myung-Gyu Choi, editors.
    Springer2015
    This atlas, featuring a wealth of high-quality images, offers a comprehensive overview of therapeutic gastrointestinal endoscopy for upper and lower gastrointestinal diseases. Both established and new therapeutic techniques using advanced endoscopic devices are extensively covered. The concise text accompanying the endoscopic photographs and illustrations will enable readers to understand the details of each procedure. Special tips of practical value are highlighted and potential pitfalls, identified. The authors are experts in the field who have a great store of knowledge on a wide variety of therapeutic endoscopic procedures. Gastrointestinal endoscopy is the principal tool for the investigation and treatment of most diseases of the gastrointestinal tract. This book will provide the clear guidance that practitioners require in order to perform therapeutic gastrointestinal endoscopy optimally; it will prove indispensable for all gastrointestinal endoscopists.
  • Digital
    Hoon Jai Chun, Suk-Kyun Yang, Myung-Gyu Choi, editors.
    Springer2019
    The second edition of this atlas has been extensively revised to provide an up-to-date and comprehensive overview of therapeutic gastrointestinal endoscopy for upper and lower gastrointestinal diseases. The coverage ranges from basic but highly effective procedures like cold snare polypectomy and variceal ligation to sophisticated procedures such as peroral endoscopic myotomy and endoscopic submucosal dissection. New instruments, for example over-the-scope clips and various stents, are introduced in the relevant chapters. Furthermore, several chapters have been added to cover cutting-edge technologies for endoscopic treatment of complex conditions, including refractory gastroesophageal reflux disease and duodenal neoplasia. Many pictures have been exchanged for newer ones, most of them high-definition endoscopy photos, and schematic illustrations are used to ensure clear understanding of complex therapeutic procedures. As in the first edition, special tips of practical value are highlighted and potential pitfalls are identified, but in addition instructive cases have been added at the end of chapters. The second edition of Therapeutic Gastrointestinal Endoscopy will be an essential resource for all therapeutic endoscopists.
  • Digital
    edited by A Zarros, C Overy, K Mikami, S Sturdy, and E M Tansey.
    Wellcome Trust2017
  • Digital
    Giovanni Stanghellini, Milena Mancini.
    Cambridge2017
    Chapter 1. The technical approach to interviewing -- Chapter 2. Main criticisms of the technical approach -- Chapter 3. The meaning of symptoms in the bio-medical paradigm -- Chapter 4. The meaning of symptoms in the psycho-dynamic paradigm -- Chapter 5. The symptom as a text -- Chapter 6. The concept of "life-world" -- Chapter 7. An example of life-world analysis -- Chapter 8. What are emotions and why are they relevant to the therapeutic interview? -- Chapter 9. What are values and why are they relevant to the therapeutic interview? -- Chapter 10. The therapeutic interview as a quest for meaning -- Chapter 11. Guidelines for the therapeutic interview -- Chapter 12. A decalogue for the therapeutic interview -- Chapter 13. The life-world of borderline persons -- Chapter 14. The life-world of persons with schizophrenia -- Chapter 15. The life-world of persons with melancholia -- Chapter 16. The life-world of persons with feeding and eating disorders.
  • Digital
    Jun Chen, Jiang Wang, Ling Wei, John H. Zhang, editors.
    Springer2019
    The blood-brain-barrier prevented harmful materials entering the brain and in the meantime is a barricade to therapeutic drug delivery. Intranasal drug delivery to circumvent blood-brain-barrier was developed in the past, to take advantages of a secret passage from the olfactory epithelium into the brain-bypassing the tight junctions that encapsulated the brain from blood circulation. This timely publication of Therapeutic Intranasal Delivery for Stroke and Neurological Disorders presented some of the latest advances in intranasal delivery research, including transnasal hypothermia induction, stem cell intranasal transplantation, intranasal drug delivery in ischemic and hemorrhagic models, intranasal peptides delivery, intranasal tPA application in adults and children. Editors Jun Chen, Jian Wang, Ling Wei and John Zhang are professors from University of Pittsburgh, Johns Hopkins University, Emory University and Loma Linda University in USA.
  • Digital/Print
    Ingo K. Mellinghoff, Charles L. Sawyers, editors.
    Digital : Springer2012
    Print2012
    Setting up a Kinase Discovery and Development Project / Gideon Bollag -- Drug Efficacy Testing in Mice / William Y. Kim, Norman E. Sharpless -- Gastrointestinal Stromal Tumors / Cristina Antonescu -- EGFR Mutant Lung Cancer / Yixuan Gong, William Pao -- Targeting Oncogenic BRAF in Human Cancer / Christine A. Pratilas, Feng Xing, David B. Solit -- Beyond BRAF in Melanoma / Adil Daud, Boris C. Bastian -- JAK-Mutant Myeloproliferative Neoplasms / Ross L. Levine -- Will Kinase Inhibitors Make it as Glioblastoma Drugs? / Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel -- Predictive Genomic Biomarkers / Rakesh Kumar, Rafael G. Amado -- Epigenetic Biomarkers / Timothy A. Chan, Stephen B. Baylin -- Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer / Robert L. Cohen.
  • Digital
    edited by Michael H. Davidson, Peter P. Toth, Kevin C. Maki.
    Springer2021
    The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related to atherosclerosis and cardiovascular disease. The second edition of Therapeutic Lipidology is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
  • Digital
    J. Haslam and J. Laycock (eds).
    Springer2008
  • Digital
    Richard P. Baum, editor.
    Springer2014
    The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.
  • Digital
    edited by John Goodchild.
    Springer2011
    Therapeutic oligonucleotides / John Goodchild -- Dinucleotides containing 3-S-phosphorothiolate linkages / James W. Gaynor and Richard Cosstick -- 2-O,4-C-methyleneoxymethylene bridged nucleic acids (2,4-BNACOC) / Yoshiyuki Hari [and others] -- Non-covalent peptide-based strategy for ex vivo and in vivo oligonucleotide delivery / Laurence Crombez [and others] -- Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides / Samir El Andaloussi [and others] -- Nanoparticle for tumor targeted delivery of oligomers / Xinrong Liu, Yi Wang, and Donald J. Hnatowich -- Light-directed delivery of nucleic acids / Sigurd Bøe [and others] -- Antibody targeted siRNA delivery / Masoud M. Toloue and Lance P. Ford -- Aptamer-drug conjugation for targeted tumor cell therapy / Michael J. Donovan [and others] -- Five-step process for screening antisense compounds for efficacy: gene target IL-12Rb2 / Nikki B. Marshall, Laura L. Hauck, and Dan V. Mourich -- Diverse small non-coding RNAs in RNA interference pathways / Liande Li and Yi Liu -- Quantification of siRNAs in vitro and in vivo / Angie Cheng, Alexander V. Vlassov, and Susan Magdaleno -- Optimization of transfection conditions and analysis of siRNA potency using real-time PCR / Angie Cheng, Susan Magdaleno, and Alexander V. Vlassov -- siRNA knockdown of gene expression in endothelial cells / Emily Dennstedt and Brad Bryan -- Using RNA interference in Schistosoma mansoni / Rita Bhardwaj, Greice Krautz-Peterson, and Patrick J. Skelly -- Performing the labeled microRNA pull-down (LAMP) assay system : an experimental approach for high-throughput identification of microRNA-target mRNAs / Ren-Jun Hsu and Huai-Jen Tsai -- Synthesis, purification, and characterization of oligoribonucleotides that act as agonists of TLR7 and/or TLR8 / Tao Lan and Ekambar R. Kandimalla -- Synthesis, purification, and characterization of immune-modulatory oligodeoxynucleotides that act as agonists of toll-like receptor 9 / Mallikarjuna Reddy Putta, Dong Yu, and Ekambar R. Kandimalla -- Surface plasmon resonance investigation of RNA aptamer-RNA ligand interactions / Carmelo Di Primo, Eric Dausse, and Jean-Jacques Toulme -- Practical considerations for analyzing antigene RNAs (agRNAs) : RNA immunoprecipitation of argonaute protein / Jacob C. Schwartz and David R. Corey -- Inhibition of human papillomavirus expression using DNAzymes / Maria Luisa Benitez-Hess, Pablo Reyes-Gutierrez, and Luis Marat Alvarez-Salas.
  • Digital
    edited by Andrew E. Nixon.
    Springer2014
    Design of phage-displayed cystine-stabilized mini-protein libraries for proteinaceous binder engineering / Hung-Ju Chang and An-Suei Yang -- Construction of a filamentous phage display peptide library / Annette Fagerlund, Astrid Hilde Myrset, and Mari Ann Kulseth -- Engineering bioactive peptide-based therapeutic molecules / Jong Sang Ryu [and three others] -- T7 lytic phage-displayed peptide libraries : construction and diversity characterization / Lauren R.H. Krumpe and Toshiyuki Mori -- Affinity selection using filamentous phage display / Mari Ann Kulseth, Annette Fagerlund, and Astrid Hilde Myrset -- Bioprospecting open reading frames for peptide effectors / Ling Xiong and Charles Scott -- Identification of ideal peptides for heterovalent ligands / Ajay Shrivastava [and three others] -- Substrate phage display for protease substrate sequence characterization : bovine factor Xa as a model system / Hung-Ju Hsu and An-Suei Yang -- Engineering peptide therapeutics using MIMETIBODY [trademark] technology / Kristen Picha [and three others] -- Evaluation of peptides as protease inhibitors and stimulators / Hannu Koistinen [and four others] -- Assessment of antimicrobial (host defense) peptides as anti-cancer agents / Susan Douglas, David W. Hoskin, and Ashley L. Hilchie -- Peptide labelling strategies for imaging agents / Tuulia Huhtal [and three others] -- Peptide optimization and conjugation strategies in the development of molecularly targeted magnetic resonance imaging contrast agents / Andrew F. Kolodziej [and four others] -- Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis / Joshua D. Ochocki [and five others] -- Ultraviolet absorption spectroscopy of peptides / Mangala R. Liyanage [and three others] -- Fluorescence spectroscopy of peptides / Mangala R. Liyanage [and three others] -- Circular dichroism of peptides / Kunal Bakshi [and three others] -- Fourier transform infrared spectroscopy of peptides / Kunal Bakshi [and three others].
  • Digital
    edited by Brian K. Meyer.
    ScienceDirect2012
  • Digital
    edited by Vladimir Voynov, Justin A. Caravella.
    Springer2012
    Therapeutic proteins / Dimiter S. Dimitrov -- Synthetic antibody libraries / Bryce Nelson and Sachdev S. Sidhu -- Construction of "phylomer" peptide libraries as a rich source of potent inhibitors of protein/protein interactions / Nadia Milech and Paul Watt -- Ribosome display and screening for protein therapeutics / Damjana Kastelic and Mingyue He -- Yeast display of engineered antibody domains / Qi Zhao, Zhongyu Zhu, and Dimiter S. Dimitrov -- Expression, purification, and characterization of engineered antibody CH2 and VH domains / Rui Gong, Weizao Chen, and Dimiter S. Dimitrov -- Engineering of affibody molecules for therapy and diagnostics / Joachim Feldwisch and Vladimir Tolmachev -- Protein design for diversity of sequences and conformations using dead-end elimination / Karl J.M. Hanf -- Design and generation of DVD-Ig(TM) molecules for dual-specific targeting / Enrico DiGiammarino, Tariq Ghayur, and Junjian Liu -- Engineering and expression of bibody and tribody constructs in mammalian cells and in the yeast Pichia pastoris / Steve Schoonooghe -- Use of E. coli for the production of a single protein / Lili Mao and Masayori Inouye -- Folding engineering strategies for efficient membrane protein production in E. coli / Brent L. Nannenga and François Baneyx -- Transient expression technologies : past, present, and future / Sabine Geisse and Bernd Voedisch -- Stable transfection pools for large quantity of protein production / Jianxin Ye -- Mammalian stable expression of biotherapeutics / Thomas Jostock and Hans-Peter Knopf -- Transgenic expression of therapeutic proteins in Arabidopsis thaliana seed / Cory L. Nykiforuk and Joseph G. Boothe -- Methods for chromatographic removal of endotoxin / Adam J. Lowe, Cameron L. Bardliving, and Carl A. Batt -- Effectiveness of various processing steps for viral clearance of therapeutic proteins : database analyses of commonly used steps / Dana Cipriano, Michael Burnham, and Joseph V. Hughes -- High-throughput quantitative N-glycan analysis of glycoproteins / Margaret Doherty [and others] -- High-throughput multimodal strong anion exchange purification and N-glycan characterization of endogenous glycoprotein expressed in glycoengineered Pichia pastoris / Sujatha Gomathinayagam [and others] -- Databases and tools in glycobiology / Natalia V. Artemenko [and others] -- Characterization of PEGylated biopharmaceutical products by LC/MS and LC/MS/MS / Lihua Huang and P. Clayton Gough -- Identification of asp isomerization in proteins by ¹⁸O labeling and tandem mass spectrometry / Jennifer Zhang and Viswanatham Katta -- Monitoring of subvisible particles in therapeutic proteins / Satish K. Singh and Maria R. Toler -- Size-exclusion chromatography with multi-angle light scattering for elucidating protein aggregation mechanisms / Erinc Sahin and Christopher J. Roberts -- Computational methods to predict therapeutic protein aggregation / Patrick M. Buck [and others] -- Coarse-grained simulations of protein aggregation / Troy Cellmer and Nicolas L. Fawzi -- Chitosan-based nanoparticles as delivery systems of therapeutic proteins / Pedro Fonte [and others] -- Challenges in the development and manufacturing of antibody-drug conjugates / Laurent Ducry.
  • Digital
    Volker A. Erdmann, Guido Reifenberger, Jan Barciszewski, editors.
    Springer2009
  • Digital
    Thomas Platz, editor.
    Springer2016
    Neurophysiology of rTMS -- Brain imaging ? network effects of rTMS -- Basic principles of rTMS in motor recovery after stroke -- Clinical applications of rTMS in motor rehabilitaton after stroke -- rTMS in dysphagia after stroke -- Basic principles of rTMS in aphasia treatment after stroke -- Therapeutic applications of rTMS for aphasia after stroke -- rTMS in visual neglect after stroke -- Clinical applications of rTMS in Parkinson?s disease -- rTMS in the treatment of neuropathic pain -- Therapeutic applications of rTMS for tinnitus -- General concepts of therapeutic rTMS in neurology.
  • Digital
    Naoki Satō, editor.
    Springer2018
  • Digital
    Gajanan V. Sherbet.
    ScienceDirect2013
    Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination.
  • Digital
    edited by Luc Friboulet.
    ScienceDirect2021
  • Digital
    Eyal Lederman DO, PHD, director, Centre for Professional Development in Manual and Physical Therapies ; Senior Lecturer, University College London (UCL), London, UK.
    ScienceDirect2014
    Introduction to therapeutic and functional stretching -- Functional and dysfunctional ROM -- Causes of ROM loss and therapeutic potential of rehabilitation -- Adaptation in ROM loss and recovery -- Specificity in ROM rehabilitation -- The overloading condition for recovery -- Exposure and scheduling the ROM challenge -- Rehabilitating the active ROM : neuromuscular rehabilitation -- Pain management and ROM-desensitization -- Stretch tolerance model -- Psychological and behavioral considerations in ROM rehabilitation -- Towards a functional approach -- Demonstration of functional approach in ROM rehabilitation
  • Digital
    edited by Chi Hin Cho.
    World Scientific2017
    "This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases."--Publisher's website.
  • Digital/Print
    edited by Iqbal S. Grewal.
    Digital : Springer2009
    Print2009
    Overview of TNF superfamily : a chest full of potential therapeutic targets / Iqbal S. Grewal -- Therapeutic interventions targeting CD40l (CD154) and CD40 : the opportunities and challenges / Che-Leung Law and Iqbal S. Grewal -- Targeting TNF for treatment of cancer and autoimmunity / Gautam Sethi ... [et al.] -- Targeting of BAFF and APRIL for autoimmunity and oncology / Maureen C. Ryan and Iqbal S. Grewal -- The role of FASL and FAS in health and disease / Martin Ehrenschwender and Harald Wajant -- OX40 (CD134) and OX401 / Michael J. Gough and Andrew D. Weinberg -- Targeting CD70 for human therapeutic use / Tamar Boursalian ... [et al.] -- 4-1BB as a therapeutic target for human disease / Seung-Woo Lee and Michael Croft -- Rank(l) as a key target for controlling bone loss / Andreas Leibbrandt and Josef M. Penninger -- Targeting the light-HVEM pathway / Carl F. Ware -- GITR : a modulator of immune response and inflammation / Giuseppe Nocentini and Carlo Riccardi -- Targeting CD30/CD30l in oncology and autoimmune and inflammatory diseases / Ezogelin Oflazoglu, Iqbal S. Grewal, and Hans Peter Gerber -- Tumor necrosis factor receptor superfamily member 21 : TNFR-related death receptor-6, DR6 / Robert Benschop, Tao Wei, and Songqing Na -- TRAIL and other TRAIL receptor agonists as novel cancer therapeutics / Christina Falschlehner ... [et al.] -- Therapeutic potential of VEGI/TL1A -- In autoimmunity and cancer / Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal.
  • Digital/Print
    Jean-Michel Escoffre, Ayache Bouakaz, editors
    Digital : Springer2016
    Print2016
    Part I -- High Intensity Focused Ultrasound Ablation of Pathological Tissue -- Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar -- Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouvière, S. Crouzet, A. Gelet -- Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries -- Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer -- F.M. Knuttel, M.A.A.J. van den Bosch -- Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer -- T.D. Khokhlova, J.H. Hwang -- Chapter 6. MR-guided Transcranial Focused Ultrasound -- J.F. Aubry, M. Tanter -- Chapter 7. Focused Ultrasound & Lithotripsy -- T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto -- Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu -- Part II -- Drug and Gene Delivery using Bubble-assisted Ultrasound -- Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis -- Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikov -- Chapter 11. Design of Microbubbles for Gene/Drug Delivery T. Bettinger, F. Tranquart -- Chapter 12. Co-administration of Microbubbles and Drugs in Ultrasound-assisted Drug Delivery: Comparison with Drug-carrying Particles R. Suzuki, A.L. Klibanov -- Chapter 13. Drug-loaded Perfluorocarbon Nanodroplets for Ultrasound-mediated Drug delivery N. Rapoport -- Chapter 14. Bubble-assisted Ultrasound: Application in Immunotherapy and Vaccination J.M. Escoffre, R. Deckers, C. Bos, C. Moonen -- Chapter 15. Sonoporation: Application for Cancer Therapy -- J. Qin, T.Y. Wang, J.K. Willmann -- Chapter 16. Microbubble-assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System A. Burgess, K. Hynynen -- Chapter 17. Microbubbles & Ultrasoun: Therapeutic Applications in Diabetic Nephropathy W.J. Cao, P.N. Matkar, H.H. Chen, A. Mofid, H. Leong-Poi -- Chapter 18. Drug and Gene Delivery using Sonoporation for Cardiovascular Disease J. Castle, S.B. Feinstein -- Chapter 19. Sonothrombolysis K.B. Bader, G. Bouchoux, C.K. Holland -- Part III- Other Ultrasound Therapy -- Chapter 20. Ultrasound-mediated Polymeric Micelle Drug Delivery H. Xia, Y. Zhao, R. Tong -- Chapter 21. Stimulation of Bone Repair with Ultrasound -- F. Padilla, R. Puts, L. Vico, A. Guignadon, K. Raum -- Chapter 22. Sonodynamic Therapy: Concept, Mechanism & Application to Cancer Treatment A.P. McHale, J.F. Callan, N. Nomikou, C. Fowley, B. Callen.
  • Digital
    Tarek E-Bialy, Eiji Tanaka, Dror Aizenbud, editors.
    Springer2018
    This book highlights the potential of low-intensity pulsed ultrasound, or LIPUS, to introduce a new era in dentistry by revolutionizing the approach to dental treatment and providing a cure for pathologic conditions long considered untreatable. Readers will find information on all aspects of LIPUS, from its mode of action and biologic mechanisms to the full range of emerging clinical applications. The role of LIPUS in promoting dental tissue repair and regeneration and in tissue engineering is fully explained in a series of chapters focusing on stimulation of cell metabolism in the dentocraniofacial region, bone healing, periodontal regeneration, the temporomandibular joint, pulp cell differentiation, the salivary glands, and orthodontics. The past two decades have witnessed numerous discoveries that have enhanced the scope for use of therapeutic ultrasound in dentistry. In summarizing the latest knowledge in this exciting field, the book will be of interest to dental surgeons, orthodontists, periodontists, and other practitioners.
  • Digital
    Beatriz Caiuby Labate, Clancy Cavnar, editors.
    Springer2014
    This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
  • Digital
    Hironori Nakagami, editor.
    Springer2019
  • Digital
    Enqiang Linghu, editor.
    Springer2014
    This book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods, provides the walls of the digestive tube are free of perforations. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.
  • Digital
    Enqiang Linghu, editor.
    Springer2020
    This book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.
  • Digital
    Dawn A. Marcus.
    Springer2012
    Cancer Overview -- Introduction to Therapy Dogs -- Dogs as Cancer Detectors -- Dog Therapy with Cancer Treatment -- Adding Therapy Dogs to Your Cancer Treatment Team -- Incorporating Companion Dogs into Cancer Rehab: Emotional Support -- Incorporating Companion Dogs into Cancer Rehab: Benefits from Physical Exercise for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Dog-Themed Exercise Program for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Practical Tips for Adding a Dog into the Home During Cancer Treatment and Recovery -- Resources.
  • Digital
    [edited by] Jashin J. Wu, MD, Los Angeles, CA, USA, Steven R. Feldman, MD, PhD, Departments of Dermatology, Pathology, and Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA, Mark G. Lebwohl, MD, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    ClinicalKey2017
    1. Overview of psoriasis / Michael Kelly-Sell and Johann E. Gudjonsson -- 2. Ultraviolet B phototherapy / Sandra Pena, Dane Hill, and Steven J. Feldman -- 3. Psoralen-ultraviolet light A therapy / Lauren M. Madigan and Henry W. Lim -- 4. Methotrexate / Vidhi V. Shah, Elaine J. Lin, Shivani P. Reddy, and Jashin J. Wu -- 5. Acitretin / Elaine J. Lin, Vidhi V. Shah, Shivani P. Reddy, and Jashin J. Wu -- 6. Cyclosporine / Vidhi V. Shah, Shivani P. Reddy, Elaine J. Lin, and Jashin J. Wu -- 7. Apremilast / Amit Om, Dane Hill, and Steven R. Feldman -- 8. Etanercept / Shivani P. Reddy, Vidhi V. Shah, Elaine J. Lin, and Jashin J. Wu -- 9. Infliximab / Catherine Ni, Shivani P. Reddy, and Jashin J. Wu -- 10. Adalimnumab / Shivani P. Reddy, Elaine J. Lin, Vidhi V. Shah, and Jashin J. Wu -- 11. Ustekinumab / John K. Nia and Mark G. Lebwohl -- 12. Secukinumab / Elaine J. Lin, Shivani P. Reddy, Vidhi V. Shah and Jashin J. Wu -- 13. Ixekizumab / Shivani P. Reddy, Vidhi V. Shah and Jashin J. Wu -- 14. Biosimilars / Shivani P. Reddy, Catherine Ni, and Jashin J. Wu -- 15. Combination therapies for psoriasis / Anjali S. Vekaria and Mark G. Lebwohl -- 16. Investigational therapies for psoriasis / Peter W. Hashim and Mark G. Lebwohl.
  • Print
    [edited by] Christopher S. Wilcox ; section editors, Tomas Berl ... [et al.].
  • Digital
    Joyce M.C. Teng, Ann L. Marqueling, Latanya T. Benjamin, editors.
    Springer2017
    Overview of Dermatologic Care in Children -- Management of Skin Disorders of the Newborn -- Atopic Dermatitis and Eczematous Eruptions -- Psoriasis and Other Papulosquamous Skin Disorders -- Hereditary Disorders of Cornification -- Hereditary Disorders of the Dermis -- Disorders of Hair and Nail -- Disorders of the Sebaceous and Sweat Gland -- Cutaneous Tumor and Tumor Syndromes -- Histiocytosis and Malignancy -- Disorders of Pigmentation -- Vascular Disorders and Anomalies -- Genodermatoses and Basement Membrane Zone Diseases -- Infectious Diseases -- Viral Disease and Exanthems of the Skin -- Bites and Infestations -- Hypersensitivity Syndromes -- Photosensitivity and Photoreaction -- Collagen Vascular Diseases -- Inborn Metabolic Disorders and Endocrine Disorders -- Cutaneous Manifestations of Systemic Disease -- Cutaneous Manifestations of Psychologic Disorders and Management -- Pearls for Pediatric Dermatologic Procedures -- Light-Based Procedures in Pediatric Dermatology.
  • Digital
    Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, Karl Doghramji.
    ScienceDirect2012
    ClinicalKey2012
    Introduction to sleep medicine -- Background to sleep medicine therapeutics -- Pharmacology principles -- Insomnias -- Sleep-related breathing disorders -- Central hypersomnolence -- Movement disorders affecting sleep -- Circadian rhythm disorders -- Therapy in pediatric sleep-related disorders -- Parasomnias in adults -- Sleep-related medical disorders -- Neurologic disorders and sleep -- Therapy of sleep disturbances associated with psychiatric disorders -- Special situations and the future -- Appendix: Effects of drugs on sleep.
  • Digital
    edited by Kurt Jellinger.
    Springer1987
    The tumors of the brain similar to other pathological changes of that particular organ claim for a separate position in scientific medicine regarding biology, morphology, features of clinical manifestation, diagnostics and therapy. During the past years due to rapid progress in basic neurosciences and medical biotechnics the situation of the neuroclinician in front of brain tumors has been dramatically changed. The prerequisites for early and accurate diagnosis as well as for successful treatment also of malignant neoplasms have increased and remarkably improved. At the same time the information necessary for an appropriate pragmatic use of the available cognitive methods and therapeutic means increased along the same scale and is permanently being critically modified or changed due to fundamental new insights which come up in always shorter intervals. These facts necessitate the preparation of publications in which the state of the art is presented in possible completeness, systematic order and proper disposability for rational management and therapeutic strategies.
  • Digital
    Stephen G. Reich, Stewart A. Factor, editors.
    Springer2019
  • Digital
    Thomas Krieg, David R. Bickers, Yoshiki Miyachi (eds.).
    Springer2010
  • Digital
    Byong-Hyon Han.
    Springer2016
    Preface -- Chapter 1: Why Social Medicine? -- 1.1: The Rise of Social Medicine -- 1.2: Human-being: Homo medicus -- 1.3: History of Drug -- Chapter 2: What is a Social Medicine? -- 2.1: Concept of Social Medicine -- 2.2: Development of Social Medicine -- 2.3: Differentiation of Social Medicine -- Chapter 3: Therapy of Social Medicine -- 3.1: Concept & Scope for Therapy of Social Medicine -- 3.2: Classification for Therapy of Social Medicine -- Chapter 4: Pharmaco-gelotology -- 4.1: Introduction -- 4.2: Laughter Theory -- 4.3: Laughter Therapy -- Chapter 5: Conclusion.
  • Digital
    Scott F. M. Duncan, Christopher W. Flowers.
    Springer2015
    Presenting over 100 rehabilitation protocols for the hand and upper extremity in an easy-to-use, step-by-step format, this practical reference provides surgeons and therapists alike with a go-to source for the therapy technique or strategy appropriate for their patients. Covering injuries from the shoulder, elbow, wrist, hand and fingers, each protocol includes bullet-pointed steps in daily or weekly increments following the injury or surgery and are inherently adaptable to the specific surgical intervention or rehabilitation requirement. Procedures following arthroplasty, extensor and flexor tendon injuries, fractures and dislocations, ligament and soft tissue injures, and nerve compression syndromes are among the many and multifaceted therapies presented. This book will be an invaluable resource for the orthopedic surgeon, hand surgeon, physical therapist, occupational therapist, hand therapist and any active clinician treating injuries to the hand and upper extremity.
  • Digital
    volume editors, Hélio Elkis, Herbert Y. Meltzer.
    Karger2010
    History and current definition of treatment resistant schizophrenia / Helio Elkis -- Assessment of therapy resistant schizophrenia / Jean Pierre Lindenmayer -- Neuropsychology of treatment resistant schizophrenia / Neil D. Woodward & Herbert Y. Meltzer -- Genetic studies in treatment resistant schizophrenia / Vincenzo De Luca ... [et al.] -- Neuroimaging of treatment resistant schizophrenia / Joao Guilherme Borgio ... [et al.] -- Duration of untreated psychosis and premorbid functioning : relationship with treatment response and therapy-resistant schizophrenia / William Bobo & Herbert Meltzer -- Disease management: multidimensional approaches to incomplete recovery in psychosis / Tim J. Lambert -- The role of clozapine in the treatment of treatment-resistant schizophrenia / Herbert Meltzer -- Augmenting clozapine response in treatment resistant schizophrenia / Gary Remington -- New therapeutic strategies for resistance to clozapine and treatment resistance schizophrenia / Juliano Santos Souza ... [et al.] -- Eletroconvulsive therapy for treatment- refractory schizophrenia / Worrawat Chanpattana -- Treatment of therapy-resistant auditory verbal hallucinations in schizophrenia patients by repetitive transcranial magnetic stimulation (rTMS) / Martin Jandl & Wolfgang P. Kaschka.
  • Digital
    Mizuki Nishino, editor.
    Springer2020
  • Digital
    edited by Jun Wu.
    Springer2017
  • Digital
    Jujjavarapu Satya Eswari, Swasti Dhagat, Ramkrishna Sen.
    Springer2019
    Thermophiles and hyperthermophiles exhibit great biotechnological potential, as they can be utilized in processes which require higher temperatures. This book comprehensively deals with all the aspects of thermophiles, starting from the source of these organisms to their latest applications. In addition it presents a compilation of all compounds produced by various thermophilic microorganisms. Due to their application in everyday life, the demands of enzymes that can work at higher temperature have been increasing. In order to keep pace with the increasing demand the industries have to search novel thermophiles producing their product of interest. Hence, this book will be of value for industries working on various biochemical products produced by these thermophiles as well as for scientists and research scholars working on microbiology and products derived from microorganisms.
  • Print
    contributors, J.C. Bolomey ... [et al.] ; edited by M.H. Seegenschmiedt, P. Fessenden, and C.C. Vernon ; foreword by L.W. Brady and H.-P. Heilmann.
    v. 1. Biology, physiology, physics -- v. 2 Clinical applications.
  • Digital
    volume editor, Andrej A. Romanovsky.
    ScienceDirectpt. 1
    ScienceDirectpt. 2
  • Digital/Print
    volume editor, Frank E. Marino.
    Digital : Karger2008
    Print2008
    The evolutionary basis of thermoregulation and exercise performance / F.E. Marino -- Comparative thermoregulation and the quest for athletic supremacy / F.E. Marino -- Thermoregulation, fatigue, and exercise modality / R. Tucker -- Neuromuscular response to exercise heat stress / S.S. Cheung -- Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : the "canary in the coal mine" during exercise-heat stress? / G.P. Lambert -- Effects of peripheral cooling on characteristics of local muscle / E. Drinkwater -- Cooling interventions for the protection and recovery of exercise performance from exercise-induced heat stress / R. Duffield -- Ethnicity and temperature regulation / M.I. Lambert, T. Mann, J.P. Dugas -- Exercise heat stress and metabolism / T. Mündel.
  • Digital
    Subhash Chandra Parija, Vikram Kate, editors.
    Springer2018
    This book on Thesis Writing for Master's and Ph.D. program focuses on the difficulties students encounter with regard to choosing a guide; selecting an appropriate research title considering the available resources; conducting research; and ways to overcome the hardships they face while researching, writing and preparing their dissertation for submission. Thesis writing is an essential skill that medical and other postgraduates are expected to learn during their academic career as a mandatory partial requirement in order to receive the Master's degree. However, at the majority of medical schools, writing a thesis is largely based on self-learning, which adds to the burden on students due to the tremendous amount of time spent learning the writing skills in addition to their exhausting clinical and academic work. Due to the difficulties faced during the early grooming years and lack of adequate guidance, acquiring writing skills continues to be a daunting task for most students. This book addresses these difficulties and deficiencies and provides comprehensive guidance, from selecting the research title to publishing in a scientific journal.
  • Digital
    David W. McCandless.
    Springer2010
    Early chemistry -- Early thiamine deficiency -- Thiamine deficiency in mammals -- Beriberi -- Wernicke's disease -- Central pontine myelinolysis, alcoholic cerebellar degeneration, and Marchiafava-Bignami disease -- Leigh's disease -- African seasonal ataxia -- Inherited ataxias -- Thiamine deficiency in serious illness -- World health concerns -- Future prospects -- Bontius translation -- Thiamine synonyms -- Nobel Prize acceptance speech of Dr. Christian Eijkman, 1929.
  • Digital
    Naseem Ahmad, Mohammad Faisal, editors.
    Springer2018
    Plant biotechnology is a most interesting branch for academicians and researchers in recent past. Now days, it becomes a very useful tool in agriculture and medicine and is regarded as a popular area of research especially in biological sciences because it makes an integral use of biochemistry, molecular biology and engineering sciences in order to achieve technological application of cultured tissues, cell and microbes. Plant tissue culture (PTC) refers to a technique of cultivation of plant cells and other parts on artificial nutrient medium in controlled environment under aseptic conditions. PTC requires various nutrients, pH, carbon source, gelling agent, temperature, photoperiod, humidity etc. and most importantly the judicious use of plant growth regulators. Various natural, adenine and phenyl urea derivatives are employed for the induction and proliferation of different types of explants. Several phenyl urea derivatives were evaluated and it was observed that thidiazuron (n-phenyl-N"-1,2,3- thidiazol-5-ulurea) was found to be the most active among the plant growth regulators. Thidiazuron (TDZ) was initially developed as a cotton defoliant and showed high cytokinin like activity. In some examples, its activity was 100 times more than BA in tobacco callus assay and produces more number of shoots in cultures than Zeatin and 2iP. TDZ also showed major breakthrough in tissue culture of various recalcitrant legumes and woody species. For the last two decades, number of laboratories has been working on TDZ with different aspect and number of publications has come out. To the best of our knowledge, there is no comprehensive edited volume on this particular topic. Hence th, e edited volume is a deed to consolidate the scattered information on role of TDZ in plant tissue culture and genetic manipulations that would hopefully prove informative to various researches. Thidiazuron: From Urea Derivative to Plant Growth Regulator compiles various aspects of TDZ in Plant Tissue Culture with profitable implications. The book will provides basic material for academicians and researchers who want to initiate work in this fascinating area of research. The book will contain 26 chapters compiled by International dignitaries and thus giving a holistic view to the edited volume.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group. The ebook package is also called Thieme Clinical Collections.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    An online journal and ebook service of the Thieme Publishing Group.
  • Digital
    Manoj Gurung, MD, Academic Hospitalist, Kent Hospital; Assistant Professor, Department of Medicine, Warren Alpert Medical School of Brown University, Rhode Island, USA, Yayra Musabek, MD, Academic Hospitalist, Kent Hospital; Assistant Professor, Department of Medicine, Warren Alpert Medical School of Brown University, Rhode Island, USA.
    Thieme MedOne Education2021
    "Thieme Review for the USMLE: A WIN for Step 2 and 3 CK by Manoj Gurung and Yayra Musabek fills a void in the available board prep materials, offering the perfect one-stop reader-friendly resource for acing these exams-truly All What Is Needed (A WIN). Allopathic and osteopathic medical students preparing for the USMLE® Step 2 and Step 3 CK or COMLEX-USA Level 2-CE and Level 3 will benefit from this must have study guide"-- Provided by publisher.
  • Digital
    Mohamed M. Elawdy, Dara B. Oken.
    Thieme MedOne Education2020
    "The first all-in-one CS review book: Addresses all three exam components: ICE, CIS, and SEP. ICE section provides systematic organization and consistency in its coverage of Medical History Taking, Physical Examination, and Patient Note. SEP section includes word-level concepts (syllables and stress), sound-level concepts (consonants and vowels), and grammar concepts CS for IMGs is a comprehensive resource designed to help IMGs pass the Step 2 CS exam on the first attempt. Practice intensive tools: Role-plays and model videos with standardized patients (SPs). SEP pronunciation and grammar explanations, exercises, and videos. Flowcharts, checklists and self-assessments Easy to replicate approach to target differential diagnosis The text and accompanying audio and videos provide an unparalleled study prep tailored to the CS that will lead to a higher score on this vital exam. Mohamed M. Elawdy, MD, MSc (Urology), is Specialist (A) in Urology, Sohar Hospital, Ministry of Health, Oman and Urology and Nephrology Center, Mansoura, Egypt; International Fellow, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Dara B. Oken, MEd, is a Pronunciation Modification Trainer, Articulation LLC and an Adult ELL Teacher , at Minneapolis Adult Education, Minneapolis Center for Adult Learning, Minneapolis, Minnesota, USA. This ground-breaking resource reflects their combined expertise preparing IMGs for the CS exam. As such, it's the only resource needed for USMLE CS prep!"-- Provided by publisher.
  • Digital
    Michael S. Humphreys, School of Psychology, The University of Queensland, Australia, Kerry A. Chalmers, School of Psychology, University of Newcastle, Australia.
    Cambridge2016
    Overview of how to analyze memory tasks -- Analysing the goals of a task -- The importance of thinking about cues and targets -- Theoretical analyses involving the use of information and its complexity -- Opportunity for learning -- The discrimination problems posed by different memory tasks -- Controlling human memory -- Episodic memory -- Conclusions.
  • Digital
    Andrew S. Garner, Robert A. Saul.
    AAP ebooks2018
    Machine generated contents note: pt. 1 Advances in Developmental Science -- ch. 1 Life Course Science and the Proverbial Black Box -- ch. 2 Defining Adversity and Toxic Stress -- ch. 3 Epigenetics -- ch. 4 Developmental Neuroscience -- ch. 5 Thinking Developmentally -- pt. 2 Translating Developmental Science Into Practice and Policy -- ch. 6 The Biological Needs of Young Children -- ch. 7 Supporting Parents and Caregivers -- ch. 8 The Role of Communities -- ch. 9 The Role of Pediatric Care -- ch. 10 Implications for Pediatric Advocacy and Public Policy.
  • Digital
    Tarek K.A. Hamid.
    Springer2009
    "Thinking in Circles About Obesity brings a healthy portion of critical thinking, spiced with on-target humor and lively graphics, to the obesity debate. Systems and medical physiology scholar Tarek Hamid unites systems (non-linear) thinking and information technology to provide insights and practical strategies for managing our weight and our health. Hamid's clear insights dispel dieters' unrealistic expectations and illuminate dead-end behaviors to tap into a deeper understanding how the body works, why it works that way, and how to better manage it." --Book Jacket.
  • Digital/Print
    edited by Enrique Cadenas and Lester Packer.
    Digital : ScienceDirect2010
    Print2010
    Changing paradigms in thiology: from antioxidant defense toward redox regulation / Leopold Flohé -- Mass spectrometry-based methods for the determination of sulfur and related metabolite concentrations in cell extracts / Emmanuel Godat ... [et al.] -- Use of dimedone-based chemical probes for sulfenic acid detection: evaluation of conditions affecting probe incorporation into redox-sensitive proteins / Chananat Klomsiri ... [et al.] -- Use of dimedone-based chemical probes for sulfenic acid detection: methods to visualize and identify labeled proteins / Kimberly J. Nelson ... [et al.] -- Formation and reactions of sulfenic acid in human serum albumin / Beatriz Alvarez ... [et al.] -- Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection / Li-Peng Yap ... [et al.] -- Measurement of mixed disulfides including glutathionylated proteins / Raffaella Priora ... [et al.] -- Detection and quantification of protein disulfides in biological tissues: a fluorescence-based proteomic approach / Viviana I. Pérez ... [et al.] -- Measurement and identification of S-glutathiolated proteins / Bradford G. Hill ... [et al.] -- Proteome screens for Cys residues oxidation: the redoxome / Giovanni Chiappetta ... [et al.] -- Identification by MS/MS of disulfides produced by a functional redox transition / Pierluigi Mauri ... [et al.] -- Mass spectrometry approaches for the redox characterization of protein cysteine residues: the case of the transcription factor Pax-8 / Andrea Scaloni and Gianluca Tell -- A simple method to systematically study oxidatively modified proteins in biological samples and its applications / Byoung-Joon Song, Soo-Kyung Suh and Kwan-Hoon Moon -- Direct and indirect detection methods for the analysis of S-nitrosylated peptides and proteins / Federico Torta, Lisa Elviri and Angela Bachi -- A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method / Joseph R. Burgoyne and Philip Eaton -- Protein addicts of aldehydic lipid peroxidation products: identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometry / Claudia S. Maier ... [et al.].
  • Digital/Print
    edited by Enrique Cadenas and Lester Packer.
    Digital : ScienceDirect2010
    Print2010
    Engineering of Fluorescent Reporters into Redox Domains to Monitor Electron Transfers / Derek Parsonage ... [et al.] -- Blot-Based Detection of Dehydroalanine-Containing Glutathione Peroxidase with the Use of Biotin-Conjugated Cysteamine / Sue Goo Rhee, Chun-Seok Cho -- Analysis of the Redox Regulation of Protein Tyrosine Phosphatase Superfamily Members Utilizing a Cysteinyl-Labeling Assay / Benoit Boivin, Nicholas K. Tonks -- Measuring the Redox State of Cellular Peroxiredoxins by Immunoblottin / Andrew G. Cox, Christine C. Winterbourn, Mark B. Hampton -- Thiol Redox Transitions by Thioredoxin and Thioredoxin-Binding Protein-2 in Cell Signaling / Eiji Yoshihara ... [et al.] -- Detection of Protein Thiols in Mitochondrial Oxidative Phosphorylation Complexes and Associated Proteins / Kelly K. Andringa, Shannon M. Bailey -- Mitochondrial Thioredoxin Reductase: Purification, Inhibitor Studies, and Role in Cell Signaling / Maria Pia Rigobello, Alberto Bindoli -- Measuring Mitochondrial Protein Thiol Redox State / Raquel Requejo ... [et al.] -- Measurement of Extracellular (Exofacial) Versus Intracellular Protein Thiols / Jolanta Skalska, Steven Bernstein, Paul Brookes -- Redox Clamp Model for Study of Extracellular Thiols and Disulfides in Redox Signaling / Young-Mi Go, Dean P. Jones -- Redox State of Human Serum Albumin in Terms of Cysteine-34 in Health and Disease / Karl Oettl, Gunther Marsche -- Methods for Studying Redox Cycling of Thioredoxin in Mediating Preconditioning-Induced Survival Genes and Proteins / Chuang C. Chiueh -- Oxidative Stress, Thiol Redox Signaling Methods in Epigenetics / Isaac K. Sundar ... [et al.] -- Characterization of Protein Targets of Mammalian Thioredoxin Reductases / Anton A. Turanov, Dolph L. Hatfield, Vadim N. Gladyshev -- Alteration of Thioredoxin Reductase 1 Levels in Elucidating Cancer Etiology / Min-Hyuk Yoo ... [et al.] -- Regulation of Apoptosis Signal-Regulating Kinase 1 in Redox Signaling / Kazumi Katagiri, Atsushi Matsuzawa, Hidenori Ichijo -- Protocols for the Detection of S-Glutathionylated and S-Nitrosylated Proteins In Situ / Scott W. Aesif, Yvonne M.W. Janssen-Heininger, Niki L. Reynaert -- Synthesis, Quantification, Characterization, and Signaling Properties of Glutathionyl Conjugates of Enals / Sanjay Srivastava ... [et al.] -- Thioredoxin and Redox Signaling in Vasculature--Studies Using Trx2 Endothelium-Specific Transgenic Mice / Wang Min ... [et al.]
  • Digital
    James M. Goldfarb, editor.
    Springer2014
    The first IVF conceived birth in 1978 resulted in a significant growth of third party reproductive options which continue to raise ethical, legal, and psychological questions. Third party reproduction procedures can involve as many as five people: sperm donor, egg donor, gestational carrier, and intended parents. Third-Party Reproduction: A Comprehensive Guide utilizes experts in the field to address the medical, psychological, ethical and legal aspects of sperm donation, egg donation, embryo donation, and the use of gestational carriers. In addition, there are chapters on the medical and ethical aspects of posthumous reproduction, religious aspects of third party reproduction, and how to avoid pitfalls of third party reproduction. Aimed at physicians, trainees, psychologists, nurses, and social workers whose practices may include patients considering third party reproduction, the intent of this book is to provide a comprehensive and practical overview of the many aspects of third party reproduction to help all those involved to better understand them. Patients considering third party reproduction may also find value in this book.
  • Digital
    Markus Heilig.
    eBook Comp Acad2015
    "The past twenty-five years have witnessed a revolution in the science of addiction, yet we still rely upon sorely outdated methods of treatment. Expensive new programs for managing addiction are also flourishing, but since they are not based in science, they offer little benefit to people who cannot afford to lose money or faith in their recovery. Clarifying the cutting-edge science of addiction for practitioners and general readers, The Thirteenth Step pairs stories of real patients with explanations of key concepts relating to their illness. A police chief who disappears on the job illustrates the process through which a drug can trigger the brain circuits mediating relapse. One person's effort to find a burrito shack in a foreign city illuminates the reward prediction error signaled by the brain chemical dopamine. With these examples and more, this volume paints a vivid, relatable portrait of drug seeking, escalation, and other aspects of addiction and suggests science-based treatments that promise to improve troubling relapse rates. Merging science and human experience, The Thirteenth Step offers compassionate, valuable answers to anyone who hopes for a better handle on a pernicious and confounding disease."--Publisher description.
  • Digital
    Campbell, Morag Allan; Easterby-Smith, Sarah; Fyfe, Aileen.
    2020Published Sept. 2019
    1. Caring for the insane in nineteenth-century Scotland -- 2. Locating and measuring puerperal insanity -- 3. Exploring family and community narratives -- 4. Treatment, recovery and release -- 5. Child murder and insanity: Judgement, custody and care.
  • Print
    Marilyn Berger.
    Story of Dr. Rick Hodes, who ended up at Mother Teresa's mission in Addis Ababa, Ethiopia, caring for the sickest children in one of the world's poorest countries.
  • Digital
    Jeroen Hendrikse.
    Springer2017
    Although many things can go wrong in the brain, this book also shows that our brain is strong. It highlights the key findings that can be seen on magnetic resonance imaging (MRI) and computed tomography (CT) scans, including those related to normal brain aging and common diseases such as brain infarcts, fractures of the skull as well as fractures and tumors of the vertebral column. It offers insights into brain MRI and CT scans, enabling readers to interpret the key findings.
  • Digital
    edited by Stephen J. Forman, Robert S. Negrin, Joseph H. Antin, Frederick R. Appelbaum.
    Wiley2016
  • Digital
    Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard.
    ClinicalKey2016
    Introduction to the human genome -- The human genome: gene structure and function -- Human genetic diversity: mutation and polymorphism -- Principles of clinical cytogenetics and genome analysis -- The chromosomal and genomic basis of disease: disorders of the autosomes and sex chromosomes -- Patterns of single-gene inheritance -- Complex inheritance of common multifactorial disorders -- Genetic variation in populations -- Identifying the genetic basis for human disease -- The molecular basis of genetic disease : general principles and lessons from the hemoglobinopathies -- The molecular, biochemical, and cellular basis of genetic disease -- The treatment of genetic disease -- Developmental genetics and birth defects -- Cancer genetics and genomics -- Risk assessment and genetic counseling -- Prenatal diagnosis and screening -- Application of genomics to medicine and personalized health care -- Ethical and social issues in genetics and genomics.
  • Digital
    managing editor, Ph. Harris ; editorial board, J.C. Christensen [and others] ; advisory board, P. Albert Lasierra [and others].
    Springer1987
    Owing to their frequency and possible consequences and considering the fact they frequently affect young people, traumatic lesions of the thoraco-lumbar spine represent a special point of interest within the field of Neurotraumatology. Traffic accidents are the commonest cause, which accounts for the high peak of occurrence between 15 and 24 years of age. It is also worth noting that according to published series nearly 50% of the cases affect the thoraco-lumbar junction. From an anatomical point of view, we must note the severity of thoracic spinal cord lesions especially of the thoraco-lumbar junction and of the lumbar region and be able to associate injuries of the conus medullaris and of the cauda equina where there is a possibility of neurological recovery. Clinical evaluation is not always easy, but remains the basis for diagnosis and prognosis. The neurological classification proposed by FRANKEL et al. in 1969 and used at STOKE MANDEVILLE Hospital seems to retain its value. A more sophisticated study of medullary evoked potentials, as described by TSUBOKAWA can allow a more precise localisation and appreciation of the extent of the lesion as well as a better evaluation of the prognosis and of the evaluation of treatment in the acute phase...
  • Print
    [translated from the Swedish by Victor Braxton].
    1. Surgical technique and a clinical study on 79 patients.
  • Digital
    Michael Galanski ; with contributions by Sabine Dettmer [and others].
    Thieme MedOne Radiology2010
    Thieme MedOne Education2010
    Congenital disorders -- Disorders of the airways -- Occupational diseases -- Infections -- Idiopathic interstitial pneumonia -- Collagen diseases and vasculitis -- Immune disorders and disorders of uncertain etiology -- Bronchopulmonary neoplasms -- Disorders of the pulmonary circulatory system -- Mediastinal disorders -- Chest wall and pleura -- Chest trauma -- Sequelae of therapy.
  • Digital
    edited by Carlos Santiago Restrepo, Steven M. Zangan.
    Thieme MedOne Radiology2011
  • Digital
    edited by Jo-Anne O. Shepard ; associate editors: Gerald F. Abbott, Jeanne B. Ackman, Subba R. Digumarthy, Matthew D. Gilman, Amita Sharma, Carol C. Wu.
    ClinicalKey2019
    Radiographic technique (fluoroscopy, digital radiography, CT, dual energy CT, dose reduction strategies) / Mannudeep K. Kalra and Alexi Otrakji -- Normal anatomy and radiographic signs / Melissa Price -- Thoracic MRI : technique and approach to diagnosis (anatomic definition, diffuse disease, masses benign and malignant, except congenital) / Jeanne B. Ackman -- Pet/ct/, pet/mri : technique, pitfalls and findings / Bojan Kovacina -- The mediastinum (anatomic definition, diffuse disease, masses benign and malignant, except congenital) / Lan Qian (Lancia) Guo and Jeanne B. Ackman -- The airways (small and large airways) / Brett Carter -- The pleura, diaphragm, and chest wall / Lan Qian (Lancia) Guo and Jeanne B. Ackman -- Congenital thoracic malformations / Justin Stowell and Christopher M. Walker -- Thoracic lines and tubes / Matthew Gilman -- Acute thoracic conditions in the intensive care unit / Susan E. Gutschow and Christopher M. Walker -- Pulmonary embolism & pulmonary vascular diseases / Shaunagh McDermott -- The post-operative chest (expected and unexpected findings) / Bojan Kovacina -- Thoracic trauma / Efren Flores and Jeanne B. Ackman -- Community acquired infections (findings and complications, including endemic fungal, viral and bacterial infections) / John Nance -- Pulmonary disease in the immunocompromised patient / Hristina Natcheva -- Mycobacterial infections (TBC and atypical infections) / Thomas Keimig, Jo Anne Shepard and Gerald Abbott -- Approach to diffuse lung disease : anatomic basis and HRCT / Amita Sharma -- Diffuse lung diseases (interstitial pneumonias, smoking related/ inhalational/occupational) / Jonathan H. Chung -- Pneumoconioses / Victorine Muse -- Obstructive lung diseases / Carol C. Wu, Brett Carter and Jo Anne Shepard -- Pulmonary tumors and lymphoproliferative disorders / Mylene Truong, Carol C. Wu, Brett Carter and Bradley S. Sabloff -- Solitary pulmonary nodule & pulmonary nodule management / Milena Petranovic -- Lung cancer screening / Shaunagh McDermott -- Staging of lung cancer (imaging and surgical evaluation) / Bojan Kovacina -- Interventional techniques / Florian J. Fintelmann, Jo Anne Shepard and Amita Sharma.
  • Print
    Amr M. Ajlan, Alexandre Semionov.
  • Digital
    editors, Stephen B. Hobbs, MD, Assistant Proffessor, Department of Radiology, Division of Cardiovascular and Thoracic Radiology, Medical Director, Radiology Informatics and Information Technology, University of Kentucky, Lexington, Kentucky, Christian W. Cox, MD, Assistant Professor, Department of Radiology, Division of Thoracic Radiology, Mayo Clinic, Rochester, Minnesota.
    Ovid2016
    Prepare for the thoracic imaging component of the new radiology Core Exam with Thoracic Imaging: A Core Review! Excel on your boards with this review book, written specifically for the new exam format. Study with all the books in the Core Review Series to ace every area of the Core Exam!
  • Digital
    edited by Stephen B. Hobbs, Christian W. Cox.
    Ovid2021
  • Digital
    Ashish Chawla, editor.
    Springer2019
    This book covers the imaging of thoracic structures with a focus on evaluation of the lungs. Pulmonary conditions are the most common global cause of mortality and morbidity, with lung cancer and tuberculosis being prevalent diseases in the developed and developing world, respectively. In the last few years there have been rapid changes in the imaging interpretation of lung diseases, particularly imaging of idiopathic pulmonary fibrosis. However, updated literature is not available yet. Filling this gap, the book provides radiologists with up-to-date, handy information on reading chest scans. This book uses standard terms and lexicons to describe the imaging findings. It consists of 14 chapters, and includes more than 1200 illustrations covering both commonly and rarely encountered conditions. The first chapter discusses imaging patterns and signs in thoracic imaging, while the chapter on interstitial lung diseases describes the hallmarks that are useful in the diagnostic pathway of these diseases. This chapter also incorporates the latest diagnostic categories of UIP based on CT patterns, and provides pictorial examples. Written by experts in the field, the book highlights imaging features and relevant clinical findings that may help in reaching diagnosis, and wherever possible, it presents the imaging features in tables for ease of memorizing.
  • Print
    Webb, Richard W.; Higgins, Charles B.
  • Digital
    W. Richard Webb, Charles B. Higgins.
    Ovid2017
    "Written by two of the world's most respected specialists in the field, Thoracic Imaging: Pulmonary and Cardiovascular Radiology, Third Edition brings you completely up to date with all you need to know for optimal imaging of the heart and lungs. This comprehensive title provides practical, authoritative guidance for the radiologic assessment and diagnosis of both congenital and acquired cardiovascular and pulmonary diseases. A must-have reference for more than ten years, Thoracic Imaging is your one-stop source for current, accurate coverage of pulmonary infections, diffuse lung diseases, mediastinal masses, coronary artery CT, myocardial disease, pericardial disease, CT of ischemic heart disease, and much more. Key Features: Today's most comprehensive text-reference in the field, written by pulmonary imaging expert W. Richard Webb, MD and cardiac imaging expert Charles B. Higgins, MD. More than 2700 high-quality images, many in full color, help you visualize key aspects of chest imaging. A new chapter on MR and CT in in Atrial and Ventricular Arrhythmias brings you up to date on the latest imaging techniques. Updated images and content throughout, including expanded coverage of PET/CT. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation, Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web. Cross-linked pages, references, and more for easy navigation. Highlighting tool for easier reference of key content throughout the text. Ability to take and share notes with friends and colleagues. Quick reference tabbing to save your favorite content for future use --Provided by publisher. "... Your one-stop source for current, accurate coverage of pulmonary infections, diffuse lung diseases, mediastinal masses, coronary artery CT, myocardial disease, pericardial disease, CT of ischemic heart disease, and much more."--Provided by publisher.
  • Print
    Soiselle, Phillip M.; Abbott, Gerald F.; McLoud, Theresa C.
  • Digital
    Karl A. Illig, Robert W. Thompson, Julie Ann Freischlag, Dean M. Donahue, Sheldon E. Jordan, Peter I. Edgelow, editors.
    Springer2013
    Thoracic outlet syndrome (TOS) is a condition estimated to affect as many as 80 of every 1000 patients in the US alone. While estimates vary widely based in part on lack of consensus as to the definition of the syndrome, as many as 3000 first rib resections are performed annually in the US. TOS comprises at least three separate conditions. The most common, neurogenic TOS, refers to the condition where the brachial plexus is compressed at the scalene triangle or retropectoral space, and is manifest as local and extremity pain and neurologic symptoms. Venous TOS refers to the situation where the subclavian vein is compressed by the structures making up the costoclavicular junction, and presents as acute or chronic venous thrombosis or injury or occasionally intermittent positional obstruction. Finally, arterial TOS refers to the situation where arterial injury occurs as the result of abnormal bony or ligamentous structures at the outlet, and presents as occlusion of or embolization from an abnormal artery in this area. Thoracic Outlet Syndrome brings together many experts who treat this disease and are leaders in their fields. While it can certainly be read in its entirety (and should, by all who concentrate on this condition), it is designed to be a clinical reference, residing on a shelf in a busy surgical, vascular or neurologic clinic where individual chapters can be quickly referenced. As such, the chapters are thorough, but concise and useful to answer when a specific question arises in the course of daily practice.
  • Digital
    Karl A. Illig, Robert W. Thompson, Julie Ann Freischlag, Dean M. Donahue, Sheldon E. Jordan, Ying Wei Lum, Hugh A. Gelabert, editors.
    Springer2021
    This extensively revised edition is an essential reference for physicians involved in the diagnosis, referral and treatment of the thoracic outlet syndrome (TOS). TOS is made up of a constellation of problems resulting from pathology at the thoracic outlet in the neck. Busy specialty practice sees multiple affected patients in every clinic, but TOS can often be difficult to diagnosis. Thoracic Outlet Syndrome explores all possible ancillary care issues surrounding this complex condition, including rehabilitation, disability, natural history and medicolegal issues, and aims to stimulate research, discussion and a sense of community between professionals involved in this area. Vascular and thoracic surgeons, neurosurgeons, neurologists, psychiatrists and psychologists, physical therapists, occupational medicine specialists and pain specialists will find this book a must read for successful treatment, referral and diagnosis of TOS in clinical practice.
  • Digital
    Aliya N. Husain.
    ClinicalKey2012
    Normal lung -- Incidental findings -- Developmental and pediatric diseases -- Pediatric tumors -- Obstructive lung (airway) diseases -- Restrictive (interstitial) lung diseases -- Granulomatous diseases (non-infectious) -- Smoking related diseases -- Miscellaneous diseases -- Diseases of vascular origin -- Pulmonary infections -- Complications of therapies -- Tumors of lung -- Nonneoplastic diseases -- Neoplastic diseases -- Normal thymus -- Nonneoplastic diseases -- Thymoma -- Other thymic tumors -- Inflammatory infectious lesions -- Cystic lesions -- Ectopic lesions -- Tumors -- Normal heart -- Congenital heart disease -- Valvular diseases -- Mycocardial diseases -- Ischemic heart disease -- Heart transplantation -- Infections -- Tumors of the heart -- Diseases of vessels.
  • Digital
    edited by Iacopo Carbone, Michele Anzidei.
    Springer2020
    This book offers a comprehensive overview of all major pathologic conditions involving the lung and mediastinum and the related diagnostic procedures. Oncologic and non-oncologic conditions are reviewed and described in detail, featuring, besides normal anatomy, also high quality images from several modalities (including X-ray, CT, MR and PET), as well as b/w and color illustrations and line drawings. Complications associated with surgical and oncological treatments are also presented in detail with extensive imaging examples. The book provides a thorough coverage of the topic of thoracic imaging, yet considering a concise and synthetic approach essential to optimal learning. The book will be a useful reference guide for the everyday clinical practice of young radiologists, residents and medical students.
  • Digital
    edited by Claudiu E. Nistor, Steven Tsui, Kaan Kırali, Adrian Ciuche, Giuseppe Aresu, Gregor J. Kocher.
    Springer2020
    This book provides a guide to the anatomy and the surgical techniques required in thoracic and cardiothoracic surgery. It discusses the advantages and disadvantages of certain surgical procedures in relation to the lymphatic system, thyroid gland, chest wall and parathyroid glands, as well as pulmonary endarterectomy. Further, it addresses intraoperative and postoperative complications, and explores newer fields like microthymectomy, microlobectomy, and pain management for thoracic surgery patients. Providing an update on the latest advances in thoracic surgery, it appeals to general, thoracic, cardiothoracic, and cardiovascular surgeons. It also offers trainees insights into the foundation of the techniques and the relevant anatomy. .
  • Digital
    edited by Douglas J. Mathisen, Christopher R. Morse ; illustrations by Body Scientific International, LLC., Anne Rains.
    LWW Health Library2015
    Take your surgical skills to the next level with Thoracic Surgery: Transplantation, Tracheal Resections, Mediastinal Tumors, Extended Thoracic Resections, a volume in the Master Techniques in Surgery Series! This thoracic surgery reference provides the richly illustrated, step-by-step guidance you need to perfect a full range of thoracic surgery techniques, avoid and manage complications, and achieve optimal outcomes. Key features: see exactly how to perform the full range of procedures, both open and minimally invasive, for lung transplantation, thoracic outlet syndrome, pectus repair, diaphr.
  • Digital
    edited by Douglas J. Mathisen, MD, Christopher R. Morse, MD ; illustrations by Body Scientific International, LLC., Anne Rains, Arains Illustration, Inc.
    LWW Health Library2015
    Take your surgical skills to the next level with Thoracic surgery: transplantation, tracheal resections, mediastinal tumors, extended thoracic resections, a volume in the Master techniques in surgery series! This thoracic surgery reference provides the richly illustrated, step-by-step guidance you need to perfect a full range of thoracic surgery techniques, avoid and manage complications, and achieve optimal outcomes.
  • Digital
    Joseph M. Galante, Raul Coimbra, editors.
    Springer2021
    This volume is a "how-to guide" to treating thoracic trauma and emergencies for acute care surgeons. It highlights the diagnosis and management of thoracic disease and injuries, and each chapter includes algorithms that lead readers through the process of identifying and treating many common and some uncommon thoracic pathologies. The international team of authors provides readers with a unique and diverse approach to the operative and non-operative challenges encountered by ACS surgeons. The large number of figures offers readers insights into what they can expect to see when caring for these patients. The editors understand that the management of adults and children differ and have included a specific chapter on pediatrics. Given the broad audience and diverse settings in which the text can be used, the authors also provide details of care in limited-resource environments. The volume is a valuable tool for professionals interested in thoracic surgery and acute care surgery
  • Digital
    Francis C. Wells, Aman S. Coonar.
    Springer2018
    This heavily revised second edition of this book provides a comprehensive overview of both common and rarely performed thoracic surgical techniques. Techniques covered include thymectomy, left and right lower lobectomy, rib resection for empyema, median sternotomy and lung biopsies. Emphasis is focused on the practical steps necessary to successfully and reliably perform the techniques covered, while acknowledgement is also given to individual variations in how these techniques are performed. Thoracic Surgical Techniques provides a detailed clinical illustrative guide for successfully performing a range of procedures reliably. Its large number of detailed illustrations and concise technical descriptions provides an invaluable resource for all practising and trainee thoracic surgeons.
  • Print
    WHO classification of tumours editorial board.
  • Digital
    Francesco Feletti, Bruna Malta, Andrea Aliverti, editors.
    Springer2020
  • Digital
    Roberto Chiesa, Germano Melissano, Alberto Zangrillo, editors ; Joseph S. Coselli, guest editor.
    Springer2011
    Section 1. General principles -- Section 2. Imaging -- Section 3. Anesthetic management -- Section 4. Treatment strategies and techniques -- Section 5. Specific problems -- Section 6. Advances in prosthetic management.
  • Digital
    Philippe Astoul, GianFranco Tassi, Jean-Marie Tschopp, editors.
    Springer2014
    The incidence of pleural disease is increasing, and it is now accepted that best practice requires the incorporation of thoracoscopy into the work-up. However, surgeons cannot meet the rising demand for thoracoscopy by means of video-assisted thoracoscopic surgery (VATS), and waiting lists for endoscopic pleural procedures are consequently lengthening. Against this background, there is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than VATS and thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as 'mini' thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.
  • Digital
    Nicola Sverzellati, Mario Silva, editors.
    Springer2020
    This book highlights the differences, in terms of neoplastic dissemination pathways, between various types of thoracic cancers. It presents and discusses a comprehensive schematic overview of tumors of the lung parenchyma, of the mediastinum, of the pleura, and of the chest wall. For each tumor, it details the local spread and the lymphatic and vascular dissemination, and it describes the challenging staging of lung tumors with mutations. Illustrations and artwork enrich the content and help readers to understand and visualize tumor spread. The book is of great interest to professionals involved in the study, diagnosis and treatment of thoracic pathologies, as well as to residents in radiology, oncology and pulmonology.
  • Digital
    Yulia Levakhina.
    Springer2014
  • Digital
    Thomas Buck, Andreas Franke, Mark J. Monaghan (editors).
    Springer2011
  • Digital
    Thomas Buck, Andreas Franke, Mark J. Monaghan (eds.).
    Springer2015
    Three-dimensional echocardiography is the most recent fundamental advancement in echocardiography with a strong impact on almost all clinical and research applications of echocardiography. After a very successful 1st edition, this book presents the fully revised 2nd edition. Accounting for the marked progress of real-time 3D echocardiography since the 1st edition it covers all clinically important aspects of this fascinating new technology, including a comprehensive explanation of its basic principles, practical aspects of clinical application, new recommendations in recent guidelines, and detailed descriptions of specific uses in the broad spectrum of clinically important heart disease. The book was written by a group of well-recognized international experts in the field, who have not only been involved in scientific and clinical evolution of 3D echocardiography since its beginnings but are also intensely involved in expert training courses. As a result, the clear focus of this book is on the practical application of 3D echocardiography in daily clinical routine with tips and tricks for both beginners and experts, all accompanied by more than 150 case examples comprehensively illustrated with more than 850 images and more than 500 videos available on a DVD. In concert with an in-depth review and comprehensive update of the most recent literature on real-time 3D echocardiography, this book continues to represent an invaluable reference on 3D echocardiography for beginners and expert users.
  • Digital
    edited by Thomas Müller-Reichart, Gaia Pigino.
    ScienceDirect2019
    Chapter 1. FIB-SEM of mouse nervous tissue: Fast and slow sample preparation / Anna M. Steyer, Andreas Schertel, Christos Nardis, Wiebke Möbius -- Chapter 2. Expedited large-volume 3-D SEM workflows for comparative microanatomical imaging / Gerald John Shami, Delfine Cheng, Filip Braet -- Chapter 3. Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM) / Valentina Baena, Richard Lee Schalek, Jeff William Lichtman, Mark Terasaki -- Chapter 4. Serial block face-scanning electron microscopy for volume electron microscopy / Saskia Lippens, Anna Kremer, Peter Borghgraef, Christopher J. Guérin -- Chapter 5. Combining serial block face and focused ion beam scanning electron microscopy for 3D studies of rare events / Christopher J. Guérin, Anna Kremer, Peter Borghgraef, Andy Y. Shih, Saskia Lippens -- Chapter 6. Yeast membraneless compartments revealed by correlative light microscopy and electron tomography / Guendalina Marini, Gaia Pigino -- Chapter 7. In situ analysis of male meiosis in C. elegans / Gunar Fabig, Anna Schwarz, Cynthia Striese, Michael Laue, Thomas Müller-Reichert -- Chapter 8. Software for automated acquisition of electron tomography tilt series / Guenter P. Resch -- Chapter 9. In situ cryo-electron tomography and subtomogram averaging of intraflagellar transport trains / Mareike A. Jordan, Gaia Pigino -- Chapter 10. CryoSTEM tomography in biology / Sharon G. Wolf, Michael Elbaum - Chapter 11. Subtomogram averaging from cryo-electron tomograms / Kendra E. Leigh, Paula P. Navarro, Stefano Scaramuzza, Wenbo Chen, Yingi Zhang, Daniel Castaño-Díez, Misha Kudryashev -- Chapter 12. Computational methods for stitching, alignment, and artifact correction of serial section data / Stephan Saalfeld -- Chapter 13. Content-aware image restoration for electron microscopy / Tim-Oliver Buchholz, Alexander Krull, Réza Shahidi, Gaia Pigino, Gáspár Jékely, Florian Jug.
  • Digital/Print
    Fabio Bagnoli, Rino Rappuoli, editors.
    Digital : Springer2021
    Print2021
    "This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab."--Back cover.
  • Digital
    Sanaz Saatchi.
    Abdominal aortic aneurysms (AAA) are described by a pathological dilation of at least 150% in the abdominal aorta. Aneurysm pathogenesis is characterized by extracellular matrix (ECM) remodeling, smooth muscle cell (SMC) apoptosis, and inflammatory cell infiltration. Overall, the structural organization and integrity of the vessel wall is lost. In order to better understand the mechanism of AAA development, a novel microscopy technology, in combination with an AAA animal model, were used to visualize and quantify the microstructural and cellular changes in the vessel wall. Therefore, the goals of this work were to introduce Immunofluorescent Array Tomography (IAT), a novel three-dimensional high resolution microscopy technology, to the field of cardiovascular research, and to apply IAT to describe the vessel wall microarchitecture of a healthy aorta, as well as to investigate the spatial and temporal changes in tissue and cellular content, structure, and organization during AAA development. The purpose of the initial studies was two-fold: to develop the methods needed to enable the application of IAT to murine blood vessels and to investigate the microarchitecture of the healthy murine aorta. The anterior and posterior regions of the infrarenal aorta of 8 to 10 week old C57BL6 mice were evaluated. Staining and custom image analysis methods were developed. Antibody selection, primary antibody concentration, co-staining with multiple primary antibodies, and the multi-cycle staining design were optimized to produce positive and specific staining of elastin, smooth muscle cell actin (SMCA), and collagen type I. Algorithms were developed and applied to the healthy murine aorta to quantify volume fractions (VF) of medial elastin (27.5 ± 0.99%), SMCA (18.4 ± 0.67%), and nuclei (6.1 ± 0.14%), as well as adventitial collagen type I (22.3 ± 1.7%). Elastin thickness (1.6 ± 0.35 [Mu]m), spacing between elastin lamellae (3.5 ± 0.13 [Mu]m), elastin fragmentation (4.2 x 10-3 ± 1.6 x 10-4 # of objects/elastin area ([Mu]m)), media wall thickness (20.4 ± 3.1 [Mu]m), nuclei aspect ratio (3.2 ± 0.21 [Mu]m), and nuclei amount (17.3 ± 0.69 nuclei) were also quantified. The 3D microstructure and cellular morphology of the anterior and posterior infrarenal murine aorta were qualitatively and quantitatively described using IAT. IAT was then used to investigate the spatial and temporal remodeling of vessel wall microarchitecture and cellular morphology during AAA development in the murine elastase perfusion model. Infrarenal aortas of C57BL6 mice (N=20) were evaluated at 0, 7 and 28 days after elastase or heat-inactivated elastase perfusion. Custom algorithms quantified VFs of elastin, SMCA, and adventitial collagen type I, as well as elastin thickness, elastin fragmentation, media thickness, and nuclei amount. 3D renderings depicted elastin and collagen type I degradation, and dynamic changes in SMC phenotype, morphology, and amount. Elastin degradation was described by a 37.5% (p < 0.01) loss in VF, 48.9% decrease in thickness, and a 449.7% (p < 0.001) increase in fragmentation over 28 days. SMCA VF decreased 78.3% (p < 0.001) from Day 0 to Day 7, and increased 139.7% (p < 0.05) from Day 7 to Day 28. Media thickness increased 61.1% and medial nuclei amount increased 159.1% (p < 0.01) over 28 days. Adventitial collagen type I VF decreased 64.1% (p < 0.001) over 28 days. IAT and custom image analysis algorithms have enabled robust quantification of vessel wall content, microstructure, and organization to help elucidate the unique dynamics of major tissue constituent remodeling during AAA development. In conclusion, the methodologies needed to enable the application of IAT to cardiovascular research have been developed, the healthy murine vessel wall microarchitecture has been qualitatively and quantitatively described, and the unique dynamics of vascular remodeling during aneurysm development have been investigated.
  • Digital
    Michael E. Maragoudakis, Nikos E. Tsopanoglou, editors.
    Springer2009
  • Digital
    Juan V. Llau, editor.
    Springer2013
    1. Thromboembolism in Orthopedic Surgery: Scope of the Problem / Bengt I. Eriksson and Ola E. Dahl -- 2. Incidence of Venous Thromboembolism in Orthopedic Surgery / Ajay K. Kakkar and Sophie K. Rushton-Smith -- 3. Specific Risk Factors for Venous Thromboembolism in Orthopedics / Lasse J. Lapidus -- 4. Diagnosis and Treatment of Deep Vein Thrombosis and Pulmonary Embolism After Major Joint Surgery / Manuel Monreal and Juan I. Arcelus -- 5. Drugs for Thromboprophylaxis: Unfractionated Heparin, Low Molecular Weight Heparin, Warfarin, and Fondaparinux / José Aguirre and Alain Borgeat -- 6. New Drugs for Thromboprophylaxis: Apixaban, Dabigatran, Rivaroxaban / Raquel Ferrandis -- 7. Effectiveness of Mechanical Devices in Orthopedic Surgery / David J. Warwick -- 8. Anesthetic Implications of Thromboprophylaxis / Sibylle A. Kozek-Langenecker -- 9. Thromboprophylaxis in High-Risk Orthopedic Surgery: Total Hip and Knee Arthroplasty and Hip Fracture / Juan V. Llau and Raquel Ferrandis -- 10. Thromboprophylaxis in Day Surgery: Knee Arthroscopy and Ligamentoplasty (Ligament Reconstruction) / James E. Muntz, Steven E. Flores, and Walter R. Lowe -- 11. Thromboprophylaxis in Special Patients: Multiple Trauma, Head Trauma, and Spine Surgery / Maria J. Colomina, Lidia Mora, and Esther Ciércoles -- 12. Management of Antiaggregated and Anticoagulated Patients Scheduled for Orthopedic Surgery / Raquel Ferrandis and Juan V. Llau.
  • Digital
    Carlos Jerjes-Sánchez.
    Springer2015
    1. Mechanisms of thrombosis -- 2. Pharmacokinetics and pharmacodynamics of fibrinolytic agents -- 3. Thrombolytic therapy: evidence-based results from multicenter control trials -- 4.Patients for thrombolysis -- 5. Anticoagulation as adjunctive treatment and one-hour alteplase infusion -- 6. Current guidelines and recommendations for thrombolysis use in pulmonary embolism -- 7. Thrombolysis in pulmonary embolism -- 8. Thrombolysis in special situations -- Index.
  • Digital/Print
    Md. Shahidul Islam, editor.
    Digital : Springer2017
    Print2017
  • Digital/Print
    Gerald Soff, editor.
    Digital : Springer2019
    Print2019
    In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.
  • Digital
    Joanne Savage and Kevin H. Wozniak.
    OSO2016
    "It's often assumed that criminologists know a great deal about violent offenders, but in fact, there is little consensus about what distinguishes them from those who commit less serious crimes. There is even less agreement about whether violent offenders can be distinguished from chronic, nonviolent offenders at all. The challenging question remains: why do some individuals commit violent offenses while so many others restrict themselves to nonviolent ones? Thugs and Thieves argues that understanding the differential etiology of violence constitutes a fundamental chasm in the criminological literature. In the introductory chapters, the authors lay out the important theoretical and methodological deficiencies that have obstructed the production of a clear set of findings to answer this question. The authors then share a highly nuanced interpretation of child development research, focused on outlining important features of early life likely to be important in the etiology of serious physical aggression and violence. They also discuss criminal motivation and contextual factors in detail. Together, these lay the foundation for the selection of "good prospects" for predicting violent offending. Separate chapters are devoted to intelligence and executive function; academic achievement and other school factors; parental attachment; parental warmth and rejection; child abuse; poverty; communities; and substance abuse. Each chapter provides a comprehensive and systematic review of the existing evidence on the topic at hand through the "differential etiology" lens, to restructure what we already know from the empirical literature. As such, the book provides a new way forward for understanding this important issue and also serves as a platform for generating hypothesis tests, directing future research, and better designing anti-violence policy. Thugs and Thieves will be of interest to criminologists, psychologists, sociologists, students, policy makers, lawmakers, and readers interested in violence and aggression"-- Provided by publisher.
  • Digital
    Sang Hyun Wo, editor.
    Springer2019
  • Digital/Print
    Thomas Boehm, Yousuke Takahama, editors.
    Digital : Springer2014
    Print2014
    The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
  • Digital
    Corrado Lavini ... [et al.], eds.
    Springer2008
  • Digital
    Geraldo A. Passos, editor.
    Springer2019
    This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.
  • Digital
    Livio Luzi, editor.
    Springer2021
    This book will provide readers with up-to-date information on thyroid diseases, obesity and metabolic syndrome. The innovative element is the presentation and exploration of possible connections linking thyroid diseases and metabolism dysfunction. Starting from the classification and diagnosis of thyroid diseases, obesity and metabolic syndrome, techniques to study and treat each of the mentioned diseases are given in an easy-to-use way. This volume will be a useful tool for endocrinologists, diabetologists, dieticians, and any professionals involved in the treatment of thyroid diseases.
  • Digital
    Giorgio Iervasi, Alessandro Pingitore, A. Martin Gerdes, Salman Razvi, editors.
    Springer2020
    In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects - kidney, hormonal pathways systems, brain, muscle, etc - of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists. .
  • Digital
    Giorgio Iervasi, Alessandro Pingitore, editors ; forewords by Paul W. Ladenson, Attilio Maseri.
    Springer2009
  • Digital
    Markus Luster, Leonidas H. Duntas, Leonard Wartofsky, editors.
    Springer2019
    This book is an up-to-date and comprehensive guide to all the common thyroid disorders that may be seen by internists, endocrinologists, nuclear medicine physicians, and endocrine surgeons. While the fundamentals of thyroid hormone function and regulation in health and disease are well covered, the primary focus is on the clinical approach to thyroid disease, with detailed coverage of both initial diagnosis and management and the role of imaging. Because most endocrine diseases are chronic and lifelong, special emphasis is placed on long-term management and the common pitfalls that may be encountered by the clinician. The editors are internationally acknowledged leaders in the field of thyroid disease and have gathered an outstanding team of authors, all of whom are also highly expert in their respective areas, but who, equally importantly, write in a clear and lucid style. The numerous isotope scan and ultrasonographic images ensure that the book will serve as a valuable reference atlas to which the physician will return again and again. .
  • Digital
    [edited by] David J. Terris, William S. Duke.
    Thieme MedOne Otolaryngology2016
  • Digital
    Glenn D. Braunstein, editor.
    Springer2012
    The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.
  • Digital
    David S. Cooper, Cosimo Durante, editors.
    Springer2016
    Part 1 Low Risk Differentiated Thyroid Cancer: Preoperative diagnosis -- Chapter 1 A patient with a single thyroid nodule suspicious for follicular neoplasm according to the Bethesda System for Reporting Thyroid Cytopathology: molecular evaluation -- Part 2 Low Risk Differentiated Thyroid Cancer: Initial management: extent of surgery and use of radioactive iodine therapy -- Chapter 2 A case of a small (1 to 2 cm) papillary thyroid cancer in a young patient: lobectomy vs. total thyroidectomy -- Chapter 3 The decision-making process for prophylactic central neck dissection in a patient presenting with nodular thyroid disease suspicious for malignancy on cytology assessment: role of preoperative ultrasound and molecular marker testing -- Chapter 4 Incidentally discovered micropapillary thyroid cancer -- Chapter 5 Completion thyroidectomy in a patient with low risk papillary cancer -- Chapter 6 A case of multifocal micropapillary thyroid cancer -- Chapter 7 A papillary thyroid cancer with minimal extra-thyroidal extension -- Chapter 8 A case of a papillary thyroid cancer with lymph node metastases found on prophylactic central neck dissection (subclinical disease, micrometastases) -- Chapter 9 Papillary thyroid cancer with central neck lymph node metastases -- Chapter 10 A patient with a large minimally invasive follicular thyroid cancer -- Chapter 11 A young patient with intrathyroidal papillary thyroid cancer and family history of differentiated thyroid cancer -- Chapter 12 A child with papillary thyroid cancer and locally advanced disease but no distant metastasis -- Part 3 Low Risk Differentiated Thyroid Cancer: Postoperative follow-up -- Chapter 13 A patient with papillary thyroid cancer and biochemical evidence of disease at the 1-yr follow-up visit -- Chapter 14 Low but detectable suppressed thyroglobulin levels in thyroid cancer patients? follow-up: How to interpret and manage these cases? -- Chapter 15 A young patient with papillary thyroid cancer and biochemical evidence of disease at the follow-up visits and increasing serum Tg values at the follow up assessments -- Chapter 16 A young patient with recurrent lymph node involvement: imaging, cytology, Tg washout -- Part 4 Low Risk Differentiated Thyroid Cancer: Special issues -- Chapter 17 Papillary thyroid carcinoma diagnosed during pregnancy -- Chapter 18 Risks of Thyroid Hormone Suppression for Differentiated Thyroid Cancer in the Elderly -- Chapter 19 A patient in whom one pathologist says she has cancer and another says that the lesion is benign -- Chapter 20: A case with postsurgical hypoparathyroidism -- Chapter 21 A case with postsurgical recurrent laryngeal nerve damage and nerve monitoring -- Part 5 High Risk Differentiated Thyroid Cancer: The need for additional therapy -- Chapter 22 A case of papillary thyroid cancer without aggressive histological features with nodal metastases detected during follow-up in a younger patient -- Chapter 23 A case of papillary thyroid cancer without aggressive histological features with nodal metastases in an older patient -- Chapter 24 A patient with a large Hũrthle cell carcinoma of the thyroid and nodal metastases -- Chapter 25 A case of a large, invasive PTC with gross residual disease (pT4) after surgery -- Part 6 High Risk Differentiated Thyroid Cancer: The use of radioiodine -- Chapter 26 A patient with papillary carcinoma of the thyroid with elevated serum thyroglobulin but negative imaging studies -- Chapter 27 A young child with papillary thyroid cancer and metastatic pulmonary disease: whole issue of radioactive iodine therapy in children -- Chapter 28 A patient with bone metastases from follicular carcinoma of the thyroid -- Chapter 29 Radioiodine Therapy in Lactating Women with High Risk Differentiated Thyroid Cancer -- Part 7 High Risk Differentiated Thyroid Cancer: The use of local treatments and novel systemic chemotherapies -- Chapter 30 A case of a patient with radioactive iodine refractory differentiated thyroid cancer with progressive neck disease (latero-cervical lymph nodes) and stable, small lung metastases -- Chapter 31 A case of an elderly patient with advanced disease and non radioiodine avid metastases -- Chapter 32 Radioactive iodine refractory differentiated thyroid cancer with multiple organ progressive disease -- Chapter 33 Radioactive iodine refractory differentiated thyroid cancer and lung lesions causing bleeding -- Chapter 34 A patient with follicular thyroid cancer and a painful bone metastasis at risk for pathologic fracture -- Chapter 35 Differentiated thyroid cancer and brain -- Part 8 High Risk Differentiated Thyroid Cancer: Novel chemotherapy and toxicity -- Chapter 36 Radioactive iodine refractory, advanced differentiated thyroid cancer receiving tyrosine kinase inhibitor treatment: checking for drug-drug interactions -- Chapter 37 A patient with advanced differentiated radioactive iodine-refractory thyroid cancer receiving tyrosine kinase inhibitor treatment: managing hypertension, QTc prolongation, dermatologic and gastrointestinal adverse events -- Part 9 Medullary Thyroid Cancer: Postoperative management -- Chapter 38 Management of post-operative hypercalcitoninemia in medullary thyroid cancer -- Chapter 39 A patient with metastatic medullary thyroid carcinoma (MTC) and tumor-related diarrhea -- Chapter 40 Clinical management of a patient with a locally recurrent medullary thyroid cancer and asymptomatic slowly progressing distant metastases -- Chapter 41 A patient with an advanced medullary thyroid cancer and progressive, symptomatic distant metastases: when to start systemic therapy -- Chapter 42 Medical Treatment Decision-Making for Advanced, Progressive Medullary Thyroid Cancer -- Part 10 Medullary Thyroid Cancer: Special issues -- Chapter 43 Screening leading to diagnosis of C cell hyperplasia -- Chapter 44 Increased basal calcitonin in nodular goiter: Is it micromedullary thyroid cancer? -- Chapter 45 Timing and extent of surgery for a pediatric patient with hereditary MTC and positive screening for the S891A RET mutation -- Part 11 Thyroid lymphoma -- Chapter 46 Thyroid Lymphoma: Differential Diagnosis -- Part 12 Anaplastic thyroid cancer -- Chapter 47 Anaplastic Thyroid Cancer: Surgery or Not in Locally Advanced Disease.
  • Digital
    edited by Giorgio Grani, David S. Cooper, Cosimo Durante.
    Springer2021
    Now in its second edition utilizing brand new clinical case material, this popular, user-friendly text presents the diagnosis and treatment of thyroid cancer and related clinical issues, providing clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various manifestations of thyroid cancer that they may encounter. Each chapter is a case report that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature. Written by experts in the field, these cases illustrate treatment for both low- and high-risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer and anaplastic thyroid cancer. Topics new to the second edition include information on management of small thyroid cancers with "active surveillance" (without surgery), new chemotherapeutic approaches to advanced thyroid cancer, and new information on a lesion that is no longer considered to be thyroid cancer (Neoplastic Follicular Thyroid Neoplasm with Papillary-Like Features [NIFTP]), as well as material on external beam radiotherapy and new approaches to the management of anaplastic thyroid cancer. Pragmatic and reader-friendly, this second edition of Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike
  • Digital
    Leonard Wartofsky, Douglas Van Nostrand, editors.
    Springer2016
  • Digital/Print
    Georg Riccabona.
    Digital : Springer1987
    Print1987
  • Digital
    edited by Shunichi Yamashita, Gerry Thomas.
    ScienceDirect2017
    Thyroid Cancer and Nuclear Accidents: Long-Term Aftereffects of Chernobyl and Fukushima discusses the radiobiological effects of the release of radioiodine from two nuclear power plant accidents and appropriate interpretation of the results of thyroid ultrasound examination. The book pulls together expert opinion on radiation related thyroid cancer in an understandable manner, even for non thyroidologists. The book explains what has been learned from both accidents in relation to prevention of thyroid cancer following nuclear power plant accidents. The book encompasses topics such as risk estimations of thyroid cancer following nuclear accidents and clinical aspects after those specific situations. Additionally, it discusses in detail the reports from Fukushima related to thyroid cancer in the population. This book is a valuable resource for oncologists and biomedical researchers with interest in nuclear accidents and cancer cases.
  • Digital
  • Digital
    Douglas P. Clark, William C. Faquin.
    Springer2010
  • Digital
    Mahmoud F. Sakr.
    Springer2020
    This volume presents and analyses the ongoing arguments, controversies, challenges and debates on thyroid disease with a view to clarifying some uncertainties, and to making suggestions that will help resolve others. Issues such as thyroid disease during pregnancy, Hashimotos disease, Hurthle cell lesions, solitary thyroid nodules, retrosternal goiter, thyroid cancer, recurrent thyroid disease, thyroidectomy techniques, post-thyroidectomy hypocalcemia, and thyroid auto-transplantation are thoroughly explored. Richly illustrated, the book offers an invaluable tool for all specialists and trainees entrusted with the care of patients suffering from thyroid disease.
  • Digital
    Ernst Nyström, Gertrud E. B. Berg, Svante K.G. Jansson, Ove Tørring, Stig V. Valdemarsson.
    Springer2011
  • Digital
    edited by Paolo Vitti, Laszlo Hegedüs.
    Springer2018
    This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.
  • Digital
    Gianni Bona, Filippo De Luca, Alice Monzani, editors.
    Springer2015
    This book covers the entire spectrum of thyroid diseases in childhood, focusing on the recent advances that have been achieved, from progress in basic science research through to novel or improved approaches to diagnosis and treatment. Introductory chapters discuss thyroid embryogenesis and the role of thyroid hormones in fetal development. The two contrasting forms of thyroid dysfunction, hypo- and hyperthyroidism, are then considered in depth, with particular attention to the molecular causes of congenital hypothyroidism. Among the other topics addressed are autoimmune thyroiditis, thyroid nodules, and pediatric neoplasms. The book concludes with an overview of promising therapeutic approaches, such as stem cell therapy. Each topic is treated by an eminent expert in the field, ensuring consistently high quality. Thyroid Diseases in Childhood will be an important source of information for endocrinologists, pediatricians, oncologists, and gynecologists, as well as other professionals interested in this topic.
  • Digital
    Syed Khalid Imam, Shamim I. Ahmad, editors.
    Springer2016
    This comprehensive book provides core understanding and clinical knowledge to all those involved in managing thyroid disorders. The authors examine the basic thyroid glandular functions which are essential in understanding the pathophysiology and clinical aspects of this disease. The chapters present recent trends, technologies and advancements in the management of thyroid diseases to help readers keep abreast of modern thyroid disease management. Some special and important issues such as pregnancy and thyroid diseases, psychiatric disorders and thyroid, and subclinical thyroid dysfunctions are also included. Thyroid Disorders - Basic Science and Clinical Practice is aimed at physicians, endocrinologists, endocrine surgeons and general surgeons with special interest in thyroid management, as well as dieticians, researchers and medical students at all levels.
  • Digital
    edited by Warren R. Heymann.
    Springer2008
    Anatomy and Embryology of the Thyroid Gland / Gabriel Wong and Scott Schaffer -- Hormones / Airani Sathananthan, Kimberly A. Placzkowski and John C. Morris -- Classification and Epidemiology of Thyroid Disease / Ghada Haddad and Steven Kaufman -- Laboratory Diagnosis of Thyroid Disease / Reagan Schiefer and Vahab Fatourechi -- Thyroglossal Duct Cysts / Lisa M. Reid -- Thyroid Cancer and the Skin / Robert A. Somer and Nati Lerman -- Chromosomes, Genes, and the Thyroid Gland / Analisa V. Halpern and Rhonda E. Schnur -- Cutaneous Manifestations of Hyperthyroidism / Clara-Dina Cokonis, Carrie W. Cobb, Warren R. Heymann and Chad M. Hivnor -- Cutaneous Manifestations of Hypothyroidism / Sandra A. Kopp, Pascal G. Ferzli, Chad M. Hivnor and Warren R. Heymann -- Pretibial Myxedema (Thyroid Dermopathy) / Vahab Fatourechi -- Alopecia and Thyroid Disease / Michelle Babb-Tarbox and Wilma F. Bergfeld -- Chronic Idiopathic Urticaria and Thyroid Disease / Jeffrey S Rumbyrt and Alan L Schocket -- Dermatologic Disorders Associated with Thyroid Disease / Joslyn Sciacca Kirby and William D. James -- Potential Therapeutic Uses of Thyroid Hormone / Joshua D. Safer and Michael F. Holick.
  • Digital
    edited by Raymond S. Douglas, Allison N. McCoy, Shivani Gupta.
    Springer2015
    This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid eye disease (TED). Particular attention is devoted to research and clinical trials that have advanced the field in recent years. Progress in our understanding of the pathogenesis of TED is described, and the heterogeneous natural history of TED is discussed to facilitate preemptive interventions. Advances in diagnostic evaluation, including autoantibody assessment, are reviewed with regard to their clinical utility. The diagnostic features of euthyroid TED are also carefully covered since these patients often represent a diagnostic dilemma. All relevant aspects of treatment are addressed including the role of radioactive iodine, long-term medical therapy, and surgical thyroidectomy. The impact of these treatment modalities on eye disease are discussed. Management of active TED is reviewed according to the severity of disease and in the light of recent findings and the introduction of novel agents. The discussion encompasses the role of steroids and other agents, the use of novel biologics, the medical and surgical treatment of optic neuropathy, and minimally invasive, customized reconstructive surgery. Numerous supporting images are included, and helpful checklists will aid the practitioner in treatment decision making.
  • Digital
    Grace C.H. Yang.
    Cambridge2013
    "In 1995, the author modified Papanicolaou stain so that fine needle aspiration cytology would resemble histology, by hemolysing aspirated blood, and making the cells flatter and appear larger by air-drying and rehydration in saline. Fine needle aspiration (FNA) is the first test used nowadays to triage thyroid nodules for medical or surgical management. FNA has led to a decrease in the number of patients undergoing surgery for benign lesions and an increase in the detection of cancer in the surgical specimens. FNA has simplified the management of patients with nodular thyroid disease and as a consequence thyroid has become the most popular site for FNA in the past ten years"--Provided by publisher.
  • Digital
    Kennichi Kakudo, editor.
    Springer2019
    This book offers a comprehensive guide to thyroid fine needle aspiration (FNA) cytology. Borderline/precursor tumors, which were introduced in the 4th edition of the WHO classification of thyroid tumors, are also incorporated. In this second edition, prominent international experts discuss the different approaches to thyroid FNA cytology employed in various countries such as Australia, Canada, China, Korea, Portugal, Switzerland, Taiwan, Thailand, Turkey, Ukraine, the USA, UK, Italy and Japan. The book not only covers key principles of thyroid cytopathology but also addresses technical aspects such as procedural complications, liquid-based cytology, immunocytochemistry, staining procedures, and potential pitfalls. Case-based descriptions and clinical findings, radiologic imaging, cytology, and histopathologic diagnosis - all complemented by a wealth of detailed photographs - will help reader understand and overcome many common dilemmas in daily practice. As such, the book represents an indispensable reference work for all cytopathologists, especially those practicing thyroid cytopathology. .
  • Digital
    edited by Gregory A. Brent.
    Springer2010
    Thyroid Hormone Metabolism / Stephen A. Huang and Luciana A. de Castro Neves -- Genetic Influences on Thyroid Function Tests / Wendy M. van der Deure, Marco Medici, Robin P. Peeters and Theo J. Visser -- Influence of Iodine Deficiency and Excess on Thyroid Function Tests / Maria Andersson and Michael B. Zimmermann -- Regulation of Thyroid Hormone Production and Measurement of Thyrotropin / Jerome M. Hershman -- Measurements of Thyroxine and Triiodothyronine / Jim R. Stockigt -- Thyroid Autoantibody Measurement / R. A. Ajjan and A. P. Weetman -- Thyroglobulin Measurement / Carole Spencer and Ivana Petrovic -- Thyroid Function Testing in Ambulatory Practice / Angela M. Leung and Alan P. Farwell -- Assessing Thyroid Function in Infants and Children / Alicia G. Marks and Stephen H. LaFranchi -- Assessing Thyroid Function in Hospitalized Patients / Jonathan S. LoPresti and Komal S. Patil -- Assessing Thyroid Function in Pregnancy / John H. Lazarus, Offie P. Soldin and Carol Evans -- Assessing Thyroid Function in the Elderly / Mary H. Samuels -- Influence of Drugs on Thyroid Function Tests / Sonia Ananthakrishnan and Elizabeth N. Pearce.
  • Digital
    edited by Michelina Plateroti, Jacques Samarut.
    Springer2018
    This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.
  • Digital
    Hossein Gharib, editor.
    Springer2018
    Utilizing the most current evidence, this practical book is the first publication of its kind to focus exclusively on the clinical and laboratory evaluation and therapy of thyroid nodules, including advances in evaluation and controversies in management. Opening with chapters presenting the epidemiology, history, laboratory and clinical evaluation of thyroid nodules, the use of radioactive isotope ultrasound and CT scanning in diagnosis is then described. The interpretation of thyroid cytology following fine needle aspiration (FNA) biopsies and the use of molecular markers are discussed in detail, as is the controversial use of thyroxine therapy. Following a presentation of the common and minimally invasive surgical approaches to thyroid nodules, chapters on multinodal goiters, incidentalomas and thyroid nodules in children round out the presentation. Written and edited by leading US and international thyroidologists, Thyroid Nodules is a useful, state-of-the-art text for endocrinologists, surgeons, and primary care physicians.
  • Digital
    editors, Alexander N. Sencha and Yury N. Patrunov.
    Springer2019
    This book is a wide-ranging and up-to-date guide to the use of ultrasound for imaging of the thyroid that will meet the needs of novices while providing more experienced professionals with advanced information. All of the techniques employed in modern thyroid ultrasound are covered, from conventional grayscale and Doppler imaging to elastography and contrast-enhanced ultrasound, with a focus on practical aspects and with detailed analysis of their diagnostic value and limitations. The characteristic ultrasound findings of the normal thyroid and a wide range of thyroid diseases and disorders are described with the aid of hundreds of high-quality images. Diffuse changes and thyroid lesions are discussed in depth, paying close attention to aspects of importance for early detection and differential diagnosis. In this context the authors summarize their personal experiences in the use of qualitative parameters of compression elastography and quantitative data of shear-wave elastography. In addition, a practical approach to the risk stratification of thyroid nodules is proposed. The book concludes with a resumé of the main challenges and pitfalls in thyroid ultrasound.
  • Digital
    H. Jack Baskin, Sr., Daniel S. Duick, Robert A. Levine, editors.
    Springer2013
    History of Thyroid Ultrasound / Robert A. Levine -- Thyroid Ultrasound Physics / Robert A. Levine -- Doppler Ultrasound of the Neck / Robert A. Levine -- Normal Neck Anatomy and Method of Performing Ultrasound Examination / Dara R. Treadwell -- Pediatric Ultrasound of the Neck / Henry J. Baskin Jr -- Ultrasound of Diffuse Thyroid Enlargement: Thyroiditis / Mark A. Lupo and Robert A. Levine -- Ultrasound of Nodular Thyroid Enlargement / Susan J. Mandel and Jill E. Langer -- Ultrasound and Mapping of Neck Lymph Nodes / Gregory Randolph, Barry Sacks and H. Jack Baskin Sr -- Ultrasonography of the Parathyroid Glands / Dev Abraham -- Surgical Trends in Treatment of Thyroid Nodules, Thyroid Cancer, and Parathyroid Disease / Haengrang Ryu, Rachel Harris and Nancy D. Perrier -- Ultrasound of Salivary Glands and the Non-endocrine Neck / Robert A. Sofferman -- Ultrasound-Guided Fine-Needle: Aspiration of Thyroid Nodules / Daniel S. Duick -- Laser and Radiofrequency Ablation Procedures / Roberto Valcavi, Giorgio Stecconi Bortolani and Fabrizio Riganti -- Percutaneous Ethanol Injection (PEI) in the Treatment of Thyroid Cysts, Nodules, and Other Neck Lesions / Andrea Frasoldati and Roberto Valcavi -- Ultrasound-Guided FNA and Molecular Markers for Optimization of Thyroid Nodule Management / Daniel S. Duick -- Ultrasound Elastography of the Thyroid / Robert A. Levine -- Authoring Quality Ultrasound Reports / J. Woody Sistrunk and H. Jack Baskin Sr.
  • Digital
    volume editors, S. Uchiyama, P. Amarenco, K. Minematsu, K.S.L. Wong.
    Karger2014
    History of transient ischemic attack definition / Mohr, J.P. -- The concept of acute cerebrovascular syndrome / Uchiyama, S. -- Transient ischemic attack as a medical emergency / Okada, Y. -- TIA clinic : a major advance in management of transient ischemic attacks / Lavalle, P.; Amarenco, P. -- Risk scores for transient ischemic attack / Wolf, M.E.; Held, V.E.; Hennerici, M.G. -- Epidemiology of transient ischemic attack / Kokubo, Y. -- Symptoms of transient ischemic attack / Kim, J.S. -- Guidelines for management of patients with transient ischemic attack / Uehara, T.; Minematsu, K. -- Radiological examinations of transient ischemic attack / Tung, C.E.; Olivot, J.M.; Albers, G.W. -- Neurosonological examinations of transient ischemic attack / Sharma, V.K.; Wong, K.S.L. -- Stroke subtypes and interventional studies for transient ischemic attack / Lavalle, P.; Amarenco, P. -- Antithrombotic therapy in transient ischemic attack patients / Held, V.E.; Wolf, M.E.; Hennerici, M.G.
  • Digital
    Porter, Stuart B.; Tidy, Noël M.
    ScienceDirect2013
    The responsibilities of being a physiotherapist / Ralph Hammond and Ceri Sedgley -- Inter-professional education and team working / Alison Chambers .̤ [et al.] -- Clinical leadership and professionalism / Alison Chambers -- Pharmacology for physiotherapists / Nicholas Southorn -- Reflection / Linda Hollingworth, Sarah Dunbar, and Lindsey Dugdill -- Respiratory diseases / Stephanie Enright and Fiona Schreuder -- Adult spontaneous and conventional mechanical ventilation / Sue Pieri-Davies, Helen Carruthers, and Melanie Reardon -- Cardiac and pulmonary rehabilitation / Sushma Sanghivi -- Physiotherapy in cardiothoracic surgery / Anne Dyson and Kelly Youd -- Changing relationships for changing health / Sally French and John Swain -- Musculoskeletal assessment / Lynne Gaskell -- Tissue inflammation and repair / Janette Grey -- Exercise in rehabilitation / Duncan Mason -- Muscle imbalance / Alan Chamberlain, Wendy Munro and Alex Rickard -- Biomechanics / Jim Richards, Renuka Erande and Ambreen Chohan -- Sports management / Hilary Pape -- Pain / Lester Jones, Lorimer Moseley, Catherine Carus -- Acupuncture / Andrew Bannan -- Electrotherapy / Tim Watson -- Physiotherapy for people with amputation / Carolyn Hale -- Massage / Joan watt -- An introduction to fractures / Annie Karim -- Upper and lower limb joint arthroplasty / Ann Price -- Older people / Bhanu Ramaswamy and Paula McCandless -- Neurodynamics / Monika Lohkamp, Katie Small, and Lee Herrington -- Neurological physiotherapy / Christine Smith, Anita Watson, and Louise Connell -- Physiotherapy in women's health / Gill Brook ... [et al.].
  • Digital
    [edited by] Nader Rifai, Andrea Rita Horvath, Carl T. Wittwer.
    ClinicalKey2018
  • Digital
    Tracey A. Martin, Wen G. Jiang, editors.
    Springer2013
    There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells.
  • Digital
    edited Tin-Lap Lee, Alfred Chun Shui Luk.
    Springer2013
    A Brief Introduction to Tiling Microarrays: Principles, Concepts, and Applications -- Design of Tiling Arrays and their Application to Bacterial Transcriptome Analysis -- Transcript Profiling in Arabidopsis with Genome Tiling Microarrays -- Genome-wide Analysis of Transcription Factor Binding Sites in Skeletal Muscle Cells using ChIP-seq -- Analysis of Allele-Specific Gene Expression Using a Target-Oriented Tiling Microarray Assay -- Detection of Epigenetic Alterations Using Tiling Arrays -- Investigating Gene Promoter Methylation in a Mouse Model of Status Epilepticus -- Integrative Analysis of ChIP-chip and ChIP-seq Dataset -- HAT: A Novel Statistical Approach to Discover Functional Regions in the Genome -- Inference of Alternative Splicing from Tiling Array Data -- Analysis of in vivo Occupancy of Aebp1, a Transcription Factor, using High Resolution Tiling Array -- Application of the Simple and Efficient MPeak Modeling in Binding Peak Identification in CHIP-CHIP Studies -- Evaluation of MeDIP-chip in the Context of Whole Genome Bisulphite Sequencing (WGBS-seq) in Arabidopsis -- Mapping Genomic Features of Tiling Microarray Data by TileMapper.
  • Digital
    by Basant Pradhan, Narsimha R. Pinninti, Shanaya Rathod.
    Springer2019
    TIMBER psychotherapy is a novel, translational and biomarker informed, mindfulness-based cognitive behavioral therapy approach that addresses some of the current treatment gaps for PTSD, depression and traumatic psychosis. This treatment manual offers practitioners and patients alike a step-by-step guide to TIMBER (acronym for Trauma Interventions using Mindfulness Based Extinction and Reconsolidation of memories) psychotherapy, and has been divided into four parts: Understanding Complex Trauma and Traumatic Psychosis; Methodology and Application; Training Professionals; and Policy Implications & Future Research Directions. In addition to a strong rationale and evidence base for the TIMBER approach, the book also provides case examples accompanied by videos (available separately). Its special features include reproducible client handouts, assessment tools, and a list of resources for training to use TIMBER.
  • Digital
    Kai Siedenburg [and 4 others], editors.
    Springer2019
    The Present, Past, and Future of Timbre Research Kai Siedenburg, Charalampos Saitis, and Stephen McAdams The Perceptual Representation of Timbre Stephen McAdams Timbre Recognition and Sound Source Identification Trevor R. Agus, Clara Suied, and Daniel Pressnitzer Memory for Timbre Kai Siedenburg and Daniel Müllensiefen The Semantics of Timbre Charalampos Saitis and Stefan Weinzierl Neural Correlates of Timbre Processing Vinoo Alluri and Sudarsana Reddy Kadiri Voice Processing and Voice-Identity Recognition Samuel Robert Mathias and Katharina von Kriegstein Timbre as a Structuring Force in Music Stephen McAdams Timbre, Sound Quality, and Sound Design Guillaume Lemaitre and Patrick Susini Timbre Perception with Cochlear Implants Jeremy Marozeau and Wiebke Lamping Audio Content Descriptors of Timbre Marcelo Caetano, Charalampos Saitis, and Kai Siedenburg Modulation Representations for Speech and Music Mounya Elhilali Timbre from Sound Synthesis and High-level Control Perspectives Sølvi Ystad, Mitsuko Aramaki, and Richard Kronland-Martinet Kai Siedenburg is Marie Sklodowska-Curie Individual Postdoctoral Fellow in the Department of Medical Physics and Acoustics at the Carl von Ossietzky Universität Oldenburg, Germany Charalampos Saitis is Lecturer and Humboldt Research Fellow in the Audio Communication Group at Technische Universität Berlin, Germany Stephen McAdams is Professor and Canada Research Chair in Music Perception and Cognition in the Department of Music Research at McGill University, Montreal, Canada Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago.
  • Print
    Philip G. Zimbardo, Richard M. Sword, Rosemary K.M. Sword.
    PTSD and time perspective therapy. How PTSD sufferers get stuck in time -- A new psychology of time -- Time perspective therapy -- The stories. War veterans, PTSD, and time perspective therapy -- Everyday trauma, PTSD, and time perspective therapy -- Women, PTSD, and time perspective therapy -- Appendix A: How TPT compares with other approaches -- Appendix B: Clinical trial: TPT pilot study research data -- Appendix C: Client psychological test scores.
  • Digital
    edited by Marcos Meseguer.
    Cambridge2016Full text HTML only
    This innovative book is one of the first resources to describe in detail the technique of digital time-lapse microscopy, a state-of-the-art analytical tool which is revolutionizing the field of assisted reproduction. Over 180 high-quality video sequences, accessible online via the password included in the book, provide a practical and highly visual guide to this new technology and the wealth of detail it can reveal about human embryo development. Written by a team of experts from across numerous clinical and scientific subspecialties, this book is a comprehensive guide to all aspects of the technique. It covers both the general principles of time-lapse microscopy and the specifics of working with various devices, with chapters on EmbryoScopeTM, Primo VisionTM and EevaTM as well as set-up and troubleshooting. Full electronic access to all text, images and supplementary videos makes this the ideal everyday reference for embryologists, clinicians and others working in IVF laboratories.
  • Digital
    recommendations from the Robert Wood Johnson Foundation Commission to Build a Healthier America.
    As we consider ways to improve our nation's overall health, we must consider options that will improve opportunities for all, with special emphasis on lifting up low-income children and those who are in danger of being left behind. A stronger, healthier America hinges on our ability to build a sustainable foundation for generations to come.
  • Digital
    Louise Olsson, editor.
    Springer2018
  • Digital
    Deborah Ruth Mary Caswell.
    Metastasis is a complex series of steps leading to the establishment of tumors at secondary sites separate from the primary tumor. Accumulating evidence supports the idea that the metastatic process varies in different cancers. Two main models of the metastatic process exist. The first is referred to as the linear progression model. In this model the primary tumor progresses to full malignancy before tumor cells disseminate from it to form metastases at secondary sites. In the other model, the parallel progression model, metastases seeded from early-disseminated tumor cells independently progress to a late stage in parallel to the primary tumor. Recently the parallel progression model has been shown to occur in both breast and pancreatic tumor mouse models. This work illustrates that in lung cancer, in opposition to breast and pancreatic cancer, dissemination and metastasis occurs at a late stage of tumor progression, after gaining specific alterations that allow tumor cells to metastasize. The exact alterations that allow tumor cells to disseminate and metastasize remain unclear, but in this work it is demonstrated that the lineage transcription factor Nkx2-1 activates a number of targets that are potentially important for metastatic ability. One in particular, Selenbp1, is shown to act in a positive feedback loop with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Using well-established mouse models in combination with massively parallel sequencing this work begins to piece together parts of the metastatic process.
  • Digital
    NCBI Bookshelf2017
  • Digital
    Jos J. Eggermont ... [et al.], editors.
    Springer2012
    Historical Reflections on Current Issues in Tinnitus / Jos J. Eggermont and Fan-Gang Zeng -- Behavioral Tests for Tinnitus in Animals / Henry E. Heffner and Rickye S. Heffner -- Molecular Mechanism of Tinnitus / Marlies Knipper, Marcus Müller and Ulrike Zimmermann -- The Cochlea and the Auditory Nerve as a Primary Source of Tinnitus / Régis Nouvian, Michel Eybalin and Jean-Luc Puel -- Dorsal Cochlear Nucleus: Somatosensory-Auditory Interactions in Tinnitus / Susanne Dehmel, Seth D. Koehler and Susan E. Shore -- The Inferior Colliculus: Involvement in Hyperactivity and Tinnitus / Donald Robertson and Wilhelmina Mulders -- Cortex: Way Station or Locus of the Tinnitus Percept? / Jos J. Eggermont -- Human Brain Imaging of Tinnitus / Jennifer R. Melcher -- The Psychophysics of Tinnitus / Brian C. J. Moore -- Stimulating the Auditory System to Treat Tinnitus: From Alleviating the Symptoms to Addressing the Causes / Arnaud J. Noreña -- Treatment: Pharmacological, Repetitive Transcranial Magnetic Stimulation, Epidural Stimulation, and Deep Brain Stimulation / Berthold Langguth, Dirk De Ridder, Tobias Kleinjung and Ana Belén Elgoyhen.
  • Digital
    edited by Berthold Langguth, Tobias Kleinjung, Dirk De Ridder, Winfried Schlee, Sven Vanneste.
    ScienceDirect2021
  • Digital
    editors, Winfried Schlee, Berthold Langguth, Tobias Kleinjung, Sven Vanneste, Dirk De Ridder.
    ScienceDirect2021
    1. Modifiable lifestyle-related risk factors for tinnitus in the general population: an overview of smoking, alcohol, body mass index and caffeine intake / Roshni Biswas -- 2. Using a Visual Analog Scale (VAS) to measure tinnitus-related distress and loudness: Investigating correlations using the Mini-TQ questionnaire results of participants from the TrackYourTinnitus platform / Albi Dode, Muntazir Mehdi, Rüdiger Pryss, Winfried Schlee and Thomas Probst -- 3. The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons / Eleni Genitsaridi, Niklas Edvall, Derek James Hoare, Christopher R. Cederroth and Deborah Ann Hall -- 4. Advancing tinnitus research and researcher training: a case study review and future perspectives / Derek James Hoare and Winfried Schlee -- 5. Investigation of the effect of HD-tDCS on tinnitus in a large patient cohort. / Laure Jacquemin -- 6. Data driven identification of tinnitus subtypes: a latent class analysis of a large sample / Berthold Langguth -- 7. Effects of Ecological Momentary Assessment (EMA) induced monitoring on tinnitus experience: a multiple-baseline single-case experiment / Matheus P C G Lourenco -- 8. Smartphone based Ecological Momentary Assessment of Tinnitus / Muntazir Mehdi -- 9. Gender differentiates effects of acoustic stimulation in Tinnitus patients / Marta Partyka -- 10. Reflections on a 5-Year Mobile Crowdsensing Ride for Tinnitus Research from a Technical Viewpoint / Rudiger Pryss -- 11. Investigating the variability of Minimum Masking Levels for tinnitus subtyping / Jose L. Santacruz -- 12. Cluster analysis of neural oscillatory correlates of hyperacusis in chronic tinnitus / Martin Schecklmann -- 13. Unification of treatments and Interventions for Tinnitus patients -- the UNITI project / Winfried Schlee -- 14. Electrophysiological evaluation of high and low frequency transcranial random noise stimulation over the auditory cortex / Stefan Schoisswohl -- 15. Time-Lagged Cross-Correlation of Tinnitus Symptoms Using Ecological Momentary Assessment / Jorge Simoes -- 16. Effectiveness of bimodal auditory and electrical stimulation' treatment in patients with tinnitus: A pilot study / Shikha Spencer -- 17. Multidisciplinary tinnitus research: challenges and future directions / Eleni Genitsaridi -- 18. Application of Latent Growth Curve Modeling to Predict Individual Trajectories during Neurofeedback Treatment for Tinnitus / Constanze Riha.
  • Digital
    editors, Winfried Schlee, Berthold Langguth, Tobias Kleinjung, Sven Vanneste, Dirk De Ridder.
    ScienceDirect2021
    Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus, Volume 262, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on current topics such as Cochlear implantation for patients with tinnitus - a systematic review, Event Related Potentials to Assess the Tinnitus complaint during drug treatment, The difference in post-stimulus suppression between residual inhibition and forward masking, Sleep, sleep apnea and tinnitus, A Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain, Tinnitus features according to caffeine consumption, and much more.
  • Digital
    Agnieszka J. Szczepek, Birgit Mazurek, editors.
    Springer2017
  • Digital
    edited by Judith E. Tintinalli, J. Stephan Stapczynski, O. John Ma, David M. Cline, Rita K. Cydulka, Garth D. Meckler, The American College of Emergency Physicians.
    AccessEmergency Medicine7th/8th ed. 2011
    Advanced airway support -- Arrhythmia management -- Resuscitation of children and neonates -- Fluids, electrolytes, and acid-base disorders -- Therapeutic approach to the hypotensive patient -- Anaphylaxis, acute allergic reactions, and angioedema -- Acute pain management and procedural sedation -- Management of patients with chronic pain -- Evaluation and preparing wounds -- Methods for wound closure -- Lacerations to the face and scalp -- Injuries of the arm, hand, fingertip, and nail -- Lacerations to the leg and foot -- Soft tissue foreign bodies -- Puncture wounds and mammalian bites -- Post repair wound care -- Chest pain: cardiac or not -- Acute coronary syndromes: management of myocardial infarction and unstable angina -- Cardiogenic shock -- Low probability acute coronary syndromes -- Syncope -- Congestive heart failure and acute pulmonary edema -- Valvular emergencies -- The cardiomyopathies, myocarditis, and pericardial disease -- Thromboembolism -- Systemic and pulmonary hypertension -- Aortic dissection and aneurysms -- Occlusive arterial disease -- Respiratory distress -- Bronchitis, pneumonia, and SARS -- Tuberculosis -- Spontaneous and latrogenic pneumothorax -- Hemoptysis -- Asthma and chronic obstructive pulmonary disease -- Acute abdominal pain -- Nausea and vomiting -- Disorders presenting primarily with diarrhea -- Acute and chronic constipation -- Gastrointestinal bleeding -- Esophageal emergencies -- Peptic ulcer disease and gastritis -- Pancreatitis and cholecystitis -- Acute appendictis -- Diverticulitis -- Intestinal obstruction and volvulus -- Hernia in adults and children -- Anorectal disorders -- Jaundice, hepatic disorders, and hepatic failure -- Complications of general surgical procedures -- Acute renal failure -- Rhabdomyolysis -- Emergencies in renal failure and dialysis patients -- Urinary tract infections and hematuria -- Acute urinary retention -- Male genital problems -- Urologic stone disease -- Complications of urologic devices -- Vaginal bleeding and pelvic pain in the nonpregnant patient -- Ectopic pregnancy and emergencies in the first 20 weeks -- Comorbid diseases in pregnancy -- Emergencies after 20 weeks pregnancy and the postpartum period -- Emergency delivery -- Vulvovaginitis -- Pelvic inflammatory disease and tube-ovarian abscess -- Complications of gynecologic procedures -- Fever and serious bacterial illness in children -- Common neonatal problems -- Common infections of the ear, nose, neck, and throat -- Upper respiratory emergencies-stridor and drooling -- Wheezing in infants and children -- Pneumonia in infants and children -- Pediatric heart disease -- Vomiting and diarrhea infants and children -- Pediatric abdominal emergencies -- Pediatric urinary tract infections -- Seizures and status epilepticus in children -- Headache and altered mental status in children -- Syncope and sudden death in children and adolescents -- Hypoglycemia and metabolic emergencies in infants and children -- The diabetic child -- Fluid and electrolye therapy -- Musculoskeletal disorders in children -- Rashes in infants and children -- Sickle cell anemia in children -- Hematologic-oncologic emergencies in children -- Renal emergencies in infants and children -- Sexually transmitted diseases -- Toxic shock -- Septic shock -- Soft tissue infections -- Disseminated viral infections -- HIV infections and AIDS -- Infective endocarditis -- Tetanus and rabies -- Malaria -- Foodborne and waterborne diseases -- Zoonotic infections -- World travelers -- The transplant patient -- General management of the poisoned patient -- Anticholinergic toxicity -- Psychopharmacologic agents -- Sedatives and hypnotics -- Alcohols -- Drugs of abuse -- Analgesics -- Xanthines and nicotine -- Cardiac medications -- Anticonvulsants -- Iron -- Hydrocarbons and volatile substances -- Caustics -- Pesticides -- Metals and metalloids -- Industrial toxins and cyanide -- Herbals and vitamins -- Dyshemoglobinemias -- Frostbite and hypothermia -- Heat emergencies -- Bites and stings -- Trauma and envenomation from marine fauna -- High-altitude medical problems -- Dysbarism and complications of diving -- Near drowning -- Thermal and chemical burns -- Electrical and lightning injuries -- Carbon monoxide -- Mushroom and plant poisoning -- Diabetic emergenices -- Alcoholic ketoacidosis -- Thyroid disease emergencies -- Adrenal insufficiency and adrenal crisis -- Evaluation of anemia and the bleeding patient -- Acquired bleeding disorders -- Hemophilias and von Willebrand disease -- Sickle cell disease and other hereditary hemolytic anemias -- Transfusion therapy -- Anticoagulants, antiplatelet agents, and fibrinolytics -- Emergency complications of malignancy -- Headache and facial pain -- Stroke, transient ischemic attack, and subarachnoid hemorrhage -- Altered mental status and coma -- Ataxia and gait disturbances -- Vertigo and dizziness -- Seizures and status epilepticus in adults -- Acute peripheral neurological lesions -- Chronic neurologic disorders -- Central nervous system and spinal infections -- Ocular emergeinces -- Face and jaw emergencies -- Oral and dental emergencies -- Neck and upper airway disorders -- Dermatologic emergencies -- Other dermatologic disorders -- Trauma in adults -- Trauma in children -- Trauma in the elderly -- Trauma in pregnancy -- Head trauma in adults and children -- Spine and spinal cord injuries in adults and children -- Facial injuries -- Trauma to the neck -- Cardiothoracic trauma -- Abdominal injuries -- Penetrating trauma to the flank and buttocks -- Genitourinary injuries -- Penetrating trauma to the extremities -- Initial evaluation and management of orthopedic injuries -- Hand and wrist injuries -- Forearm and elbow injuries -- Shoulder and humerus injuries -- Pelvis, hip, and femur injuries -- Knee and leg injuries -- Ankle and foot injuries -- Compartment syndromes -- Neck and thoracolumbar pain -- Shoulder pain -- Hip and knee pain -- Acute disorders of the joint and bursae -- Emergencies in systemic rheumatic diseases -- Infectious and noninfectious disorders of the hand -- Soft tissue problems of the foot -- Clinical features of behavioral disorders -- Emergency assessment and stabilization of behavioral disorders -- Panic and conversion disorders -- Child and elderly abuse -- Sexual assault and intimate partner violence and abuse.
  • Digital
    editor-in-chief, Judith E. Tintinalli ; co-editors, J. Stephan Stapczynski [and others].
    AccessMedicine2011
    Section 1. Prehospital Care -- Section 2. Disaster Preparedness -- Section 3. Resuscitation -- Section 4. Resuscitative Procedures -- Section 5. Analgesia, Anesthesia, and Procedural Sedation -- Section 6. Emergency Wound Management -- Section 7. Cardiovascular Disease -- Section 8. Pulmonary Emergencies -- Section 9. Gastrointestinal Emergencies -- Section 10. Renal and Genitourinary Disorders -- Section 11. Obstetrics and Gynecology -- Section 12. Pediatrics -- Section 13. Infectious Diseases -- Section 14. Neurology -- Section 15. Toxicology -- Section 16. Environmental Injuries -- Section 17. Endocrine Emergencies -- Section 18. Hematologic and Oncologic Emergencies -- Section 19. Eyes, Ears, Nose, Throat, and Oral Surgery -- Section 20. Skin Disorders -- Section 21. Trauma -- Section 22. Injuries to Bones and Joints -- Section 23. Musculoskeletal Disorders -- Section 24. Psychosocial Disorders -- Section 25. Abuse and Assault -- Section 26. Special Situations -- Section 27. Principles of Imaging. Videos of Procedures: -- Dix-Hallpike Maneuver (4 min., 55 sec.) -- Epley Maneuver (3 min., 52 sec.) -- Ultrasound: Basilic Vein Cannulation (5 min., 17 sec.) -- The Knee Exam (10 min., 52 sec.) -- Lumbar Puncture Decubitus Position (10 min., 11 sec.) -- NIH Stroke Scale (18 min., 3 sec.) -- Posterior Leg Splint (2 min., 19 sec.) -- Chest Tube Insertion (10 min.).
  • Digital
    editors, J. Stephan Stapczynski, O. John Ma, Donald M. Yealy, Garth D. Meckler, David M. Cline.
    AccessEmergency Medicine2016
    AccessMedicine2016
    Section 1. Prehospital care -- section 2. Disaster management -- section 3. Resuscitation -- section 4. Resuscitative procedures -- section 5. Analgesia, anesthesia, and procedural sedation -- section 6. Wound management -- section 7. Cardiovascular disease -- section 8. Pulmonary emergencies -- section 9. Gastrointestinal disorders -- section 10. Renal and genitourinary disorders -- section 11. Obstetrics and gynecology -- section 12. Pediatrics -- section 13. Infectious diseases -- section 14. Neurology -- section 15. Toxicology -- section 16. Environmental injuries -- section 17. Endocrine disorders -- section 18. Hematologic and oncologic disorders -- section 19. Eyes, ears, nose, throat, and oral disorders -- section 20. Dermantology -- section 21. Trauma -- section 22. Injuries to bones and joints -- section 23. Musculoskeletal disorders -- section 24. Psychosocial disorders -- section 25. Abuse and assault -- section 26. Special situations.
  • Digital
    Judith E. Tintinalli, editor-in-chief ; J. Stephan Stapczynski, O. John Ma, Donald M. Yealy, Garth D. Meckler, David M. Cline, editors.
    AccessEmergency Medicine2018
  • Digital
    [edited by] David M. Cline [and others] ; American College of Emergency Physicians.
    AccessEmergency Medicine2012
  • Digital
    [edited by] Rita K. Cydulka, David M. Cline, O. John Ma, Michael T. Fitch, Scott Joing, Vincent J. Wang.
    AccessEmergency Medicine2017
  • Digital
    Daniel S. Horwitz, Michael Suk, Teresa K. Swenson, editors.
    Springer2020
    This pocket-sized, user-friendly text provides a simple guide for the treatment of common orthopedic fractures of the upper extremity, focusing on techniques, tips and tricks. It utilizes a case-based structure with great attention given to the specific steps required to obtain excellent outcomes while also pointing out pitfalls and ways to salvage intraoperative complications. The chapters are presented anatomically from shoulder to fingertips, beginning with clavicle fractures, acromioclavicular and sternoclavicular joint injuries and scapula fractures. The various types of fracture to the humerus, elbow, radius and ulna follow, with concluding chapters covering fractures and dislocations of the wrist and hand. Throughout the book, a consistent chapter format is followed, comprised of an introduction, clinical presentation and diagnosis, relevant radiology, management strategies, outcomes, and clinical pearls and pitfalls. Incorporating the most recent implants and operative techniques, Tips and Tricks for Problem Fractures, Volume I will be a timely and handy resource for orthopedic surgeons, fellows, residents and students.
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    John C. Watkinson, David M. Scott-Coombes, editors ; Neil Sharma, Michael J. Stechman, Shahzada K. Ahemd, associate editors.
    Springer2014
    Endocrine surgery is a highly specialised field due to the technical nature of the procedures and associated risks. Despite this, endocrine operations sometimes fall to the general surgeon to deploy. Tips and Tricks in Endocrine Surgery aims to provide a concise summary of all aspects of endocrine surgery, taking into account the latest evidence and current expert opinion. The book comprises five sections covering the major endocrine organs and systems, each chapter focuses on one endocrine disorder and provides guidelines on the techniques, considerations and aspects of surgical care specific to each procedure. This book is an invaluable quick-reference resource that will appeal to higher surgical trainees in general surgery, endocrine surgery, ENT surgery and neurosurgery. Core surgical trainees preparing for examinations and consultants wishing to refresh their knowledge of the surgical management of endocrine disorders will also find this book useful.
  • Digital
    Dakshesh Parikh, Pala B. Rajesh. editors.
    Springer2018
    Thoracic incisions and access -- Common thoracic operations -- Infection: Empyema Thoracis, Bronchiectasis, Pulmonary TB, Lung abscess, Hydatid disease etc -- Lung Malformations -- Thoracic Oncology -- Thoracic wall resection and reconstruction -- Thoracic wall Deformity -- Mediastinal pathologies -- Foreign bodies both bronchus and oesophagus -- Oesophageal diseases -- Diaphragm -- Thoracic inlet disorders -- Thoracic Trauma -- Miscellaneous conditions: Namely Hyperhidrosis, Infiltrative lung disease, Pulmonary Haemorrage, chylothorax, Cystic fibrosis -- Tracheal surgery -- Transplantation.
  • Digital
    Norbert Pallua, Christoph V. Suschek, editors.
    Springer2011
    BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
  • Digital
    Narine Sarvazyan, editor.
    Springer2020
    Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field.
  • Digital
    Phuc Van Pham, editor.
    Springer2019
    Intro; Contents; Contributors; Physico-Mechanical Properties of HA/TCP Pellets and Their Three-Dimensional Biological Evaluation In Vitro; 1 Introduction; 2 Materials and Methods; 2.1 Materials; 2.2 Pellet Fabrication; 2.3 Diametral Tensile Strength (DTS) Testing; 2.4 Density Testing; 2.5 Pellet Sterilization; 2.6 Evaluation of Cell Toxicity; 2.7 Cell Attachment Assay; 2.8 Field-Emission Scanning Electron Microscopy with Energy-Dispersive X-Ray Spectroscopy (FESEM-EDX) Analysis for Surface of ...; 2.9 Statistical Analysis; 3 Results; 3.1 Pellet Structure and Morphology 3.2 Cell Toxicity Assay3.3 Osteoblast Proliferation and Attachment Assay; 3.4 FESEM-EDX Analysis of the Pellets ́Surface; 4 Discussion; 5 Conclusion; References; The Robust Potential of Mesenchymal Stem Cell-Loaded Constructs for Hard Tissue Regeneration After Cancer Removal; 1 Introduction; 2 Various Strategies Employed in TE for Hard Tissue Replacement; 2.1 Cell-Free Scaffolds Strategy; 2.2 Bioactive-Loaded Scaffolds Strategy; 2.3 Cell-Based Scaffold Strategy; 3 Requirements of Hard Tissue-Engineered Scaffolds; 3.1 Biocompatibility; 3.2 Biodegradability 3.3 Porosity, Pore Size, and Level of Pore Interconnectivity3.4 Surface Chemistry; 3.5 Mechanical Properties; 3.6 Osteoimmunomodulation; 4 Effective Parameters in the Reciprocal Cell-Scaffold Interaction; 4.1 Cell-Mediated Remodeling of Scaffolds; 4.2 Influence of Scaffold on Cellular Behaviors; 5 Cell-Loading Approaches; 6 Cell-Loaded Constructs in Clinical and Preclinical Settings; 7 Concluding Remarks; References; In Vitro Production of Cartilage Tissue from Rabbit Bone Marrow-Derived Mesenchymal Stem Cells and Polycaprolactone Scaffold; 1 Introduction; 2 Materials-Methods 2.1 Fabrication of Biodegradable Scaffolds2.2 Isolation and Characterization of Rabbit Bone Marrow-Derived Mesenchymal Stem Cells (BMMSCs); 2.3 Production of BMMSCs Expressing Green Fluorescent Protein (GFP-BMMSCs); 2.4 Seeding BMMSCs onto PCL Scaffolds; 2.5 Cell Proliferation Assay; 2.6 In Vitro Cartilage Formation; 2.7 Scanning Electron Microscopy (SEM); 2.8 Gene Expression Evaluation; 2.9 Statistical Analysis; 3 Results; 3.1 Polycaprolactone Scaffold Preparation; 3.2 Successful Isolation of Rabbit Bone Marrow-Derived Mesenchymal Stem Cells; 3.3 BMMSCs Were Successfully Transfected with GFP 3.4 BMMSCs Could Adhere and Proliferate on PCL Scaffolds and Collagen-Coated PCL Scaffolds3.5 BMMSCs Were Differentiated into Chondrocytes in the Scaffold; 4 Discussion; 5 Conclusion; References; Stem Cell Therapy for Tendon Regeneration: Current Status and Future Directions; 1 Introduction; 1.1 Tendon Injuries and Healing; 2 Application of Stem Cells, GFs, and Transcription Factors in Tendon Injury Therapies; 2.1 Stem Cells; 2.1.1 Other Important Cell Sources for Tendon Healing; 2.2 GFs in Tendon Development and Healing; 2.2.1 Effects of Different GFs on Tendon Healing
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    edited by Anwarul Hasan.
    Wiley2017
    A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.
  • Digital
    edited by Riitta Seppänen-Kaijansinkko.
    Springer2019
    This book provides a thorough, up-to-date description of the scientific basis and concepts of tissue engineering in the oral and maxillofacial region. The opening chapters present an introduction to tissue engineering, describe the roles of biomaterials and stem cells, discuss the use of growth factors, and examine potential adverse reactions. The challenges of soft and hard tissue engineering for oral and maxillofacial reconstruction are then considered in detail. It is explained what has been achieved to date, and potential future perspectives are explored. The importance and the verification of adequate vascularization are discussed, and a further focus is the use of 3D printing, both in the planning and production of scaffolds and in the bioprinting of cells and biomaterials. Information is also included on safety, efficacy, and regulatory aspects. Tissue Engineering in Oral and Maxillofacial Surgery will be of interest to all researchers and practitioners who wish to learn more about the potential of tissue engineering to revolutionize practice in oral and maxillofacial surgery.
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    Harold S. Bernstein, editor.
    Springer2011
    pt. 1. Stem cells -- pt. 2. Biomaterials and the extracellular environment -- pt. 3. Engineered tissue -- pt. 4. Synthetic organs -- pt. 5. Immune response -- pt. 6. Animal models.
  • Digital
    edited by Ronald Simon.
    Springer2010
    Applications of tissue microarray technology -- Quality aspects of TMA analysis -- Representativity of TMA studies -- Recipient block TMA technique -- Protocol for constructing tissue arrays by cutting edge matrix assembly -- Hypodermic needle without recipient paraffin block technique -- Resin technologies : construction and staining of resin TMA's -- Tissue microarrays from frozen tissues-OCT technique -- An alternative technology to prepare tissue microarray using frozen tissue samples -- Building "tissue" microarrays from suspension cells -- Tissue microarrays from biopsy specimens -- Immunohistochemical analysis of tissue microarrays -- DNA copy number analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization -- Automated analysis of tissue microarrays -- Digital microscopy for boosting database integration and analysis in TMA studies -- From gene to clinic : TMA-based clinical validation of molecular markers in prostate cancer
  • Digital
    edited by Celeste M. Nelson.
    Springer2015
    Probing regional mechanical properties of embryonic tissue using microindentation and optical coherence tomography / Benjamen A. Filas, Gang Xu, and Larry A. Taber -- Hemodynamic flow visualization of early embryonic great vessels using [mu]PIV / Selda Goktas, Chia-Yuan Chen, William J. Kowalski, and Kerem Pekkan -- Using correlative light and electron microscopy to study Zebrafish vascular morphogenesis / Jacky G. Goetz, Fabien Monduc, Yannick Schwab, and Julien Vermot -- Micro/nano-computed tomography technology for quantitative dynamic, multi-scale imaging of morphogenesis / Chelsea L. Gregg, Andrew K. Recknagel, and Jonathan T. Butcher -- Imaging the dorsal-ventral axis of live and fixed Drosophila melanogaster embryos / Sophia N. Carrell and Gregory T. Reeves -- Light sheet-based imaging and analysis of early embryogenesis in the fruit fly / Khaled Khairy [and three others] -- Quantitative image analysis of cell behavior and molecular dynamics during tissue morphogenesis / Chun Yin Bosco Leung and Rodrigo Fernandez-Gonzalez -- A multiplex fluorescent in situ hybridization protocol for clonal analysis of Drosophila oogenesis / Lily S. Cheung and Stanislav Shvartsman -- Active cell and ECM movements during development / Anastasiia Aleksandrova [and three others] -- 3D culture assays of murine mammary branching morphogenesis and epithelial invasion / Kim-Vy Nguyen-Ngoc [and five others] -- Culture of mouse embryonic foregut explants / Felicia Chen and Wellington V. Cardoso -- Investigating human vascular tube morphogenesis and maturation using endothelial cell-pericyte co-cultures and a doxycycline- inducible genetic system in 3D extracellular matrices / Stephanie L.K. Bowers [and three others] -- Three-dimensional traction force microscopy of engineered epithelial tissues / Alexandra S. Piotrowski [and three others] -- Probing cell mechanics with subcellular laser dissection of actomyosin networks in the early developing Drosophila embryo / M. Rauzi and P.-F. Lenne -- UV laser ablation to measure cell and tissue-generated forces in the Zebrafish embryo in vivo and ex vivo / Michael Smutny [and four others] -- Measurement of intercellular cohesion by tissue surface tensiometry / Ramsey A. Foty -- Quail-chick chimeras and eye development / Sinu Jasrapuria Agrawal and Peter Y. Lwigale -- Studying epithelial morphogenesis in Dictyostelium / Daniel J. Dickinson, W. James Nelson, and William I. Weis -- Primary cell cultures of regenerating Holothurian tissues / Samir A. Bello, Ricardo J. Abreu-Irizarry, and José́ E. Garcı́a-Arrarás -- Large-scale parameter studies of cell-based models of tissue morphogenesis using CompuCell3D or VirtualLeaf / Margriet M. Palm and Roeland M.H. Merks -- Simulating tissue morphogenesis and signaling / Dagmar Iber [and four others] -- Elasticity-based targeted growth models of morphogenesis / Patrick W. Alford.
  • Digital
    edited by Pietro Ghezzi, Anthony Cerami.
    Springer2013
    Erythropoietin and engineered innate repair activators / Michael Brines and Anthony Cerami -- Epo and non-hematopoietic cells : what do we know / Omolara O. Ogunshola and Anna Yu. Bogdanova -- Tissue-protective cytokines : structure and evolution / Pietro Ghezzi and Darrell Conklin -- Regenerative activity of interleukin-6 / Eithan Galun and Stefan Rose-John -- Brain ischemic injury in rodents : the protective effect of EPO / Annelise Letourneur [and others] -- Experimental traumatic spinal cord injury / Zubeyde Erbayraktar [and others] -- Erythropoietin as a neuroprotectant for beonatal brain injury : animal models / Christopher M. Traudt and Sandra E. Juul -- Evaluating effects of EPO in rodent behavioral assays related to depression / Catharine H. Duman and Samuel S. Newton -- Erythropoietin and cytoprotective cytokines in experimental traumatic brain injury / Samson Kumar Gaddam, Jovany Cruz, and Claudia Robertson -- Therapeutic efficacy of erythropoietin in experimental autoimmune encephalomyelitis in mice, a model of multiple sclerosis / Ilaria Cervellini, Pietro Ghezzi, and Manuela Mengozzi -- Deciphering the intracellular signaling of erythropoietin in neuronal cells / Murat Digicaylioglu -- Assessment of allodynia relief by tissue-protective molecules in a rat model of nerve injury-induced neuropathic pain / Maarten Swartjes, Marieke Niesters, and Albert Dahan -- Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy / Bianchi Roberto [and others] -- ARA290 in a rat model of inflammatory pain / Andrew Dilley -- In vivo angiogenic activity of erythropoietin / Domenico Ribatti -- Photoreceptor degeneration in mice : adeno-associated viral vector-mediated delivery of erythropoietin / Pasqualina Colella and Alberto Auricchio -- Myocardial infarction : cardioprotection by erythropoietin / Mark I. Talan and Roberto Latini -- Using plethysmography to determine erythropoietin's impact on neural control of ventilation / Tommy Seaborn, Max Gassmann, and Jorge Soliz -- Cerebral malaria : protection by erythropoietin / Anne-Lise Bienvenu and Stephane Picot.
  • Digital
    edited by Minnie M. Sarwal, Tara K. Sigdel.
    Springer2018
  • Digital
    edited by Brian C.-S. Liu and Joshua R. Ehrlich.
    Springer2008
    Capabilities using 2-D DIGE in proteomics research : the new gold standard for 2-D gel electrophoresis / Christine R. Rozanas and Stacey M. Loyland -- Protein carbohydrate analysis : gel-based staining, liquid chromatography, mass spectrometry, and microarray screening / Injae Shin, Alina D. Zamfir, and Bin Ye -- Surface-enhanced laser desorption/ionization mass spectrometry for protein and peptide profiling of body fluids / Audrey Gagnon, Qian Shi, and Bin Ye -- A novel approach using MALDI-TOF mass spectrometry and prestructured sample supports (AnchorChip technology) for proteomic profiling and protein identification / Sau-Mei Leung and Rebecca L. Pitts -- Automated laser capture microdissection for tissue proteomics / Adrianna S. Rodriguez ... [et al.] -- Tissue microarrays : an overview / Rajiv Dhir -- Frozen protein arrays / Stephen M. Hewitt and Robert A. Star -- Reverse phase protein microarrays for theranostics and patient-tailored therapy / Virginia Espina ... [et al.] -- Antibody arrays for determination of relative protein abundances / Grigoriy S. Chaga -- SH2 domain-based tyrosine phosphorylation array / Xin Jiang ... [et al.] -- Immunoregulomics : a serum autoantibody-based platform for transcription factor profiling / Oliver W. Tassinari ... [et al.] -- The "reverse capture" autoantibody microarray : an innovative approach to profiling the autoantibody response to tissue-derived native antigens / Joshua R. Ehrlich ... [et al.] -- Biorepository standards and protocols for collecting, processing, and storing human tissues / Dean Troyer.
  • Digital
    Joana Vieira Silva, Maria João Freitas, Margarida Fardilha, editors.
    Springer2020
    Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
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  • Digital
    volume editors, G. Kollias, P.P. Sfikakis.
    Karger2010
    TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.
  • Digital
    edited by Jagadeesh Bayry, INSERM Unité 1138, Paris, France.
    Springer2014
    Assaying NF-[kappa]B activation and signaling from TNF receptors -- Dissecting DR3 signaling -- Modulation of fc[epsilon]RI-dependent mast cell response by OX40L -- Analyzing the signaling capabilities of soluble and membrane TWEAK -- Regulation of human dendritic cell functions by natural anti-cd40 antibodies -- [Beta]-actin in the signaling of transmembrane TNF-[alpha]-mediated cytotoxicity -- Investigating the protective role of death receptor 3 (DR3) in renal injury using an organ culture model -- Analysis of TNF-[alpha]-mediated cerebral pericyte remodeling -- CD137 in chronic graft-versus-host disease -- In vitro investigation of the roles of the proinflammatory cytokines tumor necrosis factor-[alpha] and interleukin-1 in murine osteoclastogenesis -- Evasion of TNF-[alpha]-mediated apoptosis by hepatitis C virus -- TNF-[alpha] modulates TLR2-dependent responses during mycobacterial infection -- Experimental applications of TNF-reporter mice with far-red fluorescent label -- A solid-phase assay for studying direct binding of progranulin to TNFR and progranulin antagonism of TNF/TNFR interactions -- Compartment-specific flow cytometry for the analysis of TNF-mediated recruitment and activation of glomerular leukocytes in murine kidneys -- Determination of soluble tumor necrosis factor receptor 2 produced by alternative splicing -- Effective expression and purification of bioactive recombinant soluble LIGHT -- One of the TNF superfamily members: Bifunctional protein, TNFR2-Fc-IL-1ra.
  • Digital
    Wiley2021
  • Digital/Print
    edited by P. Hermanek and L.H. Sobin.
    Digital : Springer1987
    Print1987
  • Digital
    Philip Rubin, John T. Hansen.
    LWW Health Library2012
    The Second Edition of TNM Staging Atlas with 3D Oncoanatomy has been updated to include all new cancer staging information from the Seventh Edition of the AJCC Cancer Staging Manual. The atlas presents cancer staging in a highly visual rapid-reference format, with clear full-color diagrams and TNM stages by organ site. The illustrations some original and some derived from Grant's Atlas of Anatomy are three-dimensional, three-planar cross-sectional presentations of primary anatomy and regional nodal anatomy. They show the anatomic features identifiable on physical and/or radiologic examination and the anatomic extent of cancer spread which is the basis for staging. A color code indicates the spectrum of cancer progression at primary sites (T) and lymph node regions (N). The text then rapidly reviews metastatic spread patterns and their incidence. For this edition, CT or MRI images have been added to all site-specific chapters to further detail cancer spread and help plan treatment. Staging charts have been updated to reflect changes in AJCC guidelines, and survival curves from AJCC have been added to site-specific chapters"--Provided by publisher.
  • Digital
    David Clark.
    Oxford Medicine Online2016
    Palliative medicine was first recognised as a specialist field in 1987. One hundred years earlier, London based doctor William Munk published a treatise on 'easeful death' that mapped out the principles of practical, spiritual, and medical support at the end of life. In the intervening years a major process of development took place which led to innovative services, new approaches to the study and relief of pain and other symptoms, a growing interest in 'holistic' care, and a desire to gain more recognition for care at the end of life. This book traces the history of palliative medicine, from its nineteenth-century origins, to its modern practice around the world. It takes in the changing meaning of 'euthanasia', assesses the role of religious and philanthropic organisations in the creation of homes for the dying, and explores how twentieth-century doctors created a special focus on end of life care. 'To comfort always' traces the rise of clinical studies, academic programmes and international collaborations to promote palliative care. 0It examines the continuing need to support development with evidence, and assesses the dilemmas of unequal access to services and pain relieving drugs, as well as the periodic accusations of creeping medicalization within the field. This is the first history of its kind, and the breadth of information it encompasses makes it an essential resource for those interested in the long-term achievements of palliative medicine as well as the challenges that remain.
  • Digital
    The gradual increase in longevity in the United States and elsewhere has already brought about a slow-motion revolution in nearly every sector of society, from health care to housing to employment. But if radical life extension moves from the realm of fantasy to reality, that revolution will pick up considerable speed. Extending human life spans beyond those of even the oldest of our ancestors would raise a host of new social, political, economic, environmental, moral and other questions. Religious organizations have traditionally played an important role in helping people think through end-of-life matters and respond to significant social changes. But since life extension has not made the journey from fantasy to fact, there has been little official or even quasi-official guidance in this area from churches and other religious groups.
  • Digital
    Cuschieri, Sarah.
    Springer2021
    This book prepares and guides individuals who are about to embark (or already have embarked) on a health/medical PhD journey, with a specific focus on Public Health. Based on the author's experience as a recently graduated Doctor of Philosophy (PhD) student, readers benefit from the knowledge imparted and lessons learned, including an analysis of the different aspects of a Public Health doctoral degree, and practical tips and guidance on how to go about this journey from the initial phase of choosing a research niche up until the oral examination (also called defence). All throughout the book, the author shares examples from her own journey to show that in spite of sacrifices and hurdles along the way, hard work, perseverance, and supportive resources can help see you through, eventually, to a hopefully positive outcome at the end. Using an informal style, the author provides a step-wise guide, from chapter to chapter, on the various essential aspects that need to be considered, including: The initial steps towards a PhD Proposal, permissions and funding The fieldwork The art of data analysis The hurdles along the way - a personal experience What comes after the completion of a PhD? Intended to be a compact go-to guide for students throughout their PhD journey, both from an academic and personal perspective, To Do or Not to Do a PhD? engages readers who are about to enroll in or who already have started a PhD, especially in public health, epidemiology, and health/medical fields of study. The brief also would appeal to postgraduate and undergraduate students who are interested in learning about how to write a research proposal, draft a scientific paper for publication in a journal, or prepare a thesis.
  • Digital
    Medical Department of the Cincinnati College.
  • Digital
    Ruth Ilana Tennen.
    Saccharomyces cerevisiae silent information regulator 2 (Sir2) is an NAD+-dependent histone deacetylase that links chromatin silencing to genomic stability, cellular metabolism, and lifespan regulation. The human Sir2 family member SIRT6 is a highly substrate-specific histone deacetylase that promotes proper chromatin function in several physiologic contexts, including preserving telomere integrity, fine-tuning gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis. Here, we describe work aimed at expanding the molecular and cellular understanding of SIRT6. First, we report the identification of novel functions for the N- and C-terminal domains of SIRT6. We show that the C-terminal extension (CTE) of SIRT6 contributes to proper nuclear localization; the N-terminal extension (NTE) is critical for chromatin association and intrinsic catalytic activity; and mutation of a conserved catalytic histidine residue in the core sirtuin domain not only abrogates SIRT6 enzymatic activity but also leads to impaired chromatin association in cells. Second, we show that SIRT6 is required for maintenance of telomere-proximal gene silencing--a phenomenon termed telomere position effect (TPE)--in human cells. RNAi-mediated depletion of SIRT6 abrogates silencing of both an integrated telomeric transgene and an endogenous telomere-proximal gene. Moreover, enhanced telomeric silencing in response to telomere elongation is associated with increased repressive chromatin marks, and this heterochromatic milieu is lost in SIRT6-deficient cells. Together, these studies provide new insight into the molecular mechanism of SIRT6 activity; uncover a novel role for SIRT6 in regulating telomeric gene silencing; and reveal important links between SIRT6 and disease-relevant cellular processes.
  • Digital
    edited by Peter Boyle, Nigel Gray, Jack Henningfield, John Seffrin, and Witold Zatonski.
    OSO2010Limited to 3 simultaneous users
    "Comprehensively covers the science and policy issues relevant to one of the major public health disasters of modern times. It pulls together the etiology and burden of the myriad of tobacco-related diseases with the successes and failures of tobacco control policies. The book looks at lessons learnt to help set health policy for reducing the burden of tobacco-related diseases. It also deals with the international public health policy issues which bear on control of the problem of tobacco use and which vary between continents."--Publisher's description
  • Digital
    Byron C. Calhoun, Tammi Lewis, editors.
    Springer2016
    Introduction: Abuse of Tobacco and Substances -- Physiology of Nicotine -- Physiology of EtOH and Opiate Receptors -- Women's Specific Issues -- Health Effects -- Pregnancy Effects -- Tobacco Cessation -- Addictions Counseling -- Therapeutic Substitution -- Appendix: Protocols and Guidelines.

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Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available. DynaMed is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS. Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties. Provides critical assessments of systematic reviews compiled from a variety of medical journals. Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions. PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians. Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients. A continually updating drug monograph.ECRI Guidelines Trust: A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or products LPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staff Micromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class. LPCH / Stanford Hospital Formulary. A goldmine of trusted consumer health information from the world's largest medical library. A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs. Provides patient handouts from the American Academy of Family Physician. Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users. Vast collection of software and database programming titles from multiple publishers, including Microsoft Press. Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering. Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources. Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals. Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present. A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.