Books

all 660 "G" titles

G

  • 2013 ScienceDirect
    edited by P. Michael Conn.
    The protein local optimization program and g-protein-coupled receptors:loop restoration and applications to homology modeling -- Modeling active GPCR conformations -- Molecular modeling of adenosine receptors -- Predicting g-protein-coupled receptors families using differet physiochemical properties and pseudo amino acid composition -- Computational design and experimental characterization of GPCR segment models -- G-protein-coupled receptor interaction with small GTPases -- Quantification of receptor tyrosine kinase activiation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SplDA) -- NMR modeling for detection of small molecule binding to RGS4 -- Group II activators of g-protein signaling: monitoring the interaction of G[alpha] with G-protein motif in the intact cell -- Homogenous time-resolved fluorescence assay to probe folded G protein-coupled receptors -- cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors -- Rhodospin-lipid intereactions studied by NMR -- Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity -- Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands -- From heptahelical bundle to hits from the haystack: structure-based virtual screening for GPCR ligands -- Kinetics and dynamics in the G protein-coupled receptor signaling cascade -- Magic angle spinning nuclear magnetic resonance spectroscopy fo G protein-coupled receptors -- Posttranslation modification of G protein-coupled receptor in relationship to biased agonism -- Protein S-nitrosylation measurement.
  • 2013 ScienceDirect
    edited by P. Michael Conn.
    This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.
  • 2013 ScienceDirect
    edited by P. Michael Conn.
    Section 1. GPCR trafficking. Therapeutic rescue of misfolded/mistrafficked mutants : automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs / David C. Smithson, Jo Ann Janovick, and P. Michael Conn ; Trafficking of the follitropin receptor / Alfredo Ulloa-Aguirre, James A. Dias, George Bousfield, Ilpo Huhtaniemi, and Eric Reiter ; Single-molecule imaging technique to study the dynamic regulation of GPCR function at the plasma membrane / B.E. Snaar-Jagalska, A. Cambi, T. Schmidt, and S. de Keijzer ; GPCR oligomerization and receptor trafficking / Richard J. Ward, Tian-Rui Xu, and Graeme Milligan ; [Beta]-arrestins and G protein-coupled receptor trafficking / Dong Soo Kang, Xufan Tian, and Jeffrey L. Benovic ; Tracking cell surface mobility of GPCRs using [alpha]-bungarotoxin-linked fluorophores / Saad Hannan, Megan E. Wilkins, Philip Thomas, and Trevor G. Smart ; Regulatory mechanism of G protein-coupled receptor trafficking to the plasma membrane : a role for mRNA localization / Kusumam Joseph, Eleanor K. Spicer, and Baby G. Tholanikunnel ; Dissecting trafficking and signaling of atypical chemokine receptors / Elena Borroni, Cinzia Cancellieri, Massimo Locati, and Raffaella Bonecchi -- Section 2. Trafficking motifs. Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs / Carl M. Hurt, Vincent K. Ho, and Timothy Angelotti ; Identification of endoplasmic reticulum export motifs for G protein-coupled receptors / Guangyu Wu ; Amino acid residues of G-protein-coupled receptors critical for endoplasmic reticulum export and trafficking / Motonao Nakamura, Daisuke Yasuda, Nobuaki Hirota, Teruyasu Yamamoto, Satoshi Yamaguchi, Takao Shimizu, and Teruyuki Nagamune -- Section 3. GPCR oligomerization. G-protein-coupled heteromers : regulation in disease / Ivone Gomes, Achla Gupta, and Lakshmi A. Devi ; Hetero-oligomerization and specificity changes of G protein-coupled purinergic receptors : novel insight into diversification of signal transduction / Tokiko Suzuki, Kazunori Namba, Natsumi Mizuno, and Hiroyasu Nakata ; Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells / Karin F.K. Ejendal, Jason M. Conley, Chang-Deng Hu, and Val J. Watts ; G protein-coupled receptor heterodimerization in the brain / Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Pere Garriga, Francisco Ciruela, Manuel Narvaez, Alexander O. Tarakanov, Miklós Palkovits, Luigi F. Agnati, and Kjell Fuxe ; Experimental strategies for studying G protein-coupled receptor homo- and heteromerization with radioligand binding and signal transduction methods / Roberto Maggio, Cristina Rocchi, and Marco Scarselli ; Analysis of GPCR dimerization using acceptor photobleaching resonance energy transfer techniques / Marta Busnelli, Mario Mauri, Marco Parenti, and Bice Chini ; Techniques for the discovery of GPCR-associated protein complexes / Avais Daulat, Pascal Maurice, and Ralf Jockers ; Expression, purification, and analysis of G-protein-coupled receptor kinases / Rachel Sterne-Marr, Alison I. Baillargeon, Kevin R. Michalski, and John J.G. Tesmer ; Modern methods to investigate the oligomerization of glycoprotein hormone receptors (TSHR, LHR, FSHR) / Marco Bonomi and Luca Persani.
  • 2002 ScienceDirect
    edited Ravi Iyengar, John D. Hildebrandt.
    Also available: Print – 2002
  • 2002 ScienceDirect
    edited Ravi Iyengar, John D. Hildebrandt.
    Also available: Print – 2002
  • 2002 ScienceDirect
    edited Ravi Iyengar, John D. Hildebrandt.
    Also available: Print – 2002
  • 2014 Springer Protocols
    edited by Craig W. Stevens, Ph.D., Department of Pharmacology and Physiology, College of Osteopathic Medicine, Oklahoma State University-Center for Health Sciences, Tulsa, OK, USA.
    G protein-coupled receptors : research and methods in the post-genomic era / Craig W. Stevens -- Examining the dynamic evolution of G protein-coupled receptors / Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg -- Functional properties of virus-encoded and virus-regulated G protein-coupled receptors / Katja Spiess and Mette M. Rosenkilde -- Discovery and function of the very large G protein-coupled receptor / Perrin C. White and D. Randy McMillan -- Functional evolution of opioid family G protein-coupled receptors / Eyal Vardy, Craig W. Stevens, and Bryan L. Roth -- Investigation of G protein-coupled receptor function and regulation using antisense / Jonathon Willets and Craig Nash -- Signalosome profiling reveals allosteric interactions between G protein-coupled receptors / Katrin Altosaar ... [et al.] -- Use of optogenetic approaches to control intracellular signaling of G protein-coupled receptors / Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze -- Viral infection for G protein-coupled receptor expression in eukaryotic cells / Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi -- Using in vitro mutagenesis to characterize structure- function relationships in G protein-coupled receptors / Gregory W. Sawyer and Frederick J. Ehlert -- CRE Luc Mouse model for bioimaging ligand activation of G protein-coupled receptors / H. Gregory Polites and Kyriakos D. Economides -- Inducing conformational changes in G protein-coupled receptors by domain coupling / Hamiyet Unal and Sadashiva S. Karnik -- Rescue of defective G protein-coupled receptor function by intermolecular cooperation / Ashutosh Trehan ... [et al.] -- Design of super-arrestins for gene therapy of diseases associated with excessive signaling of G protein-coupled receptors / Vsevolod V. Gurevich and Eugenia V. Gurevich -- Importance of G protein-coupled receptor genetics in clinical medicine / Ramakrishna Devaki -- Pharmacogenomics of G protein-coupled receptor signaling and other pathways in essential hypertension / Pedro A. Jose ... [et al.] -- Exon sequencing of G protein-coupled receptor genes and perspectives for disease treatment / Angeliki Karamitri and Ralf Jockers -- Gene therapy using G protein-coupled receptors for the treatment of cardiovascular disease / Dario Leosco ... [et al.] -- Novel mechanisms of G protein-coupled receptor oligomer and ion channel Iiteractions in nociception / Ajay S. Yekkirala -- Discovery and characterization of leucine-rich repeat-containing G protein-coupled receptors / Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart -- Role of G protein-coupled receptors in adult neurogenesis / Katie M. Collette, Van A. Doze, and Dianne M. Perez.
  • 2015 Springer Protocols
    edited by Duarte Miguel F. Prazeresl, Sofia Aires M. Martins.
    G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins -- Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others] -- Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others] -- Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer -- cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others] -- Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst -- Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith -- Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner -- Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah -- GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas -- Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres -- Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others] -- Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others] -- Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis -- Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others] -- Label-free functional selectivity assays / Ann M. Ferrie [and others] -- Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl -- Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others] -- Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].
  • 2013 Springer Protocols
    edited by Mark P. Running.
    Remarkably, while G protein-coupled receptors (GPCRs) are highly prevalent in animals and yeast, very few candidate GPCRs have been identified in plants. In G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols, experts in the field describe techniques used in the study of small GTPases and related proteins. Beginning with a chapter on bioinformatics approaches for GPCR discovery, this detailed volume continues with chapters on heterotrimeric G protein subunits, Rab-GTPases, as well as lipid modifications, including myristoylation, acylation, and prenylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and dependable, G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols aims to aid further studies into the roles of small GTPases which will help elucidate numerous key processes in plants.
  • 2016 ScienceDirect
    edited by Arun K. Shukla.
  • 2006 CRCnetBASE
    edited by Tatsuya Haga, Shigeki Takeda.
  • 2006 CRCnetBASE
    edited by Kenneth H. Lundstrom, Mark L. Chiu.
  • 2015 Springer Protocols
    edited by Marta Filizola
    Purification of stabilized GPCRs for structural and biophysical analyses / James C. Errey ... [et al.] -- Purification and crystallization of a thermostabilized agonist-bound conformation of the human adenosine A2A receptor / Christopher G. Tate and Guillaume Lebon -- 2D projection analysis of GPCR complexes by negative stain electron microscopy / Alys Peisley and Georgios Skiniotis -- Nuts and bolts of CF3 and CH3 NMR towards the understanding of conformational exchange of GPCRs / R. Scott Prosser and Tae Hun Kim -- Single-molecule fluorescence microscopy for the analysis of fast receptor dynamics / Julia Wagner ... [et al.] -- Quantitative multi-color detection strategies for bioorthogonally labeled GPCRs / Minyoung Park ... [et al.] -- Approaches to characterize and quantify oligomerization of GPCRs / Sara Marsango, María José Varela, and Graeme Milligan -- Monitoring G protein activation in cells with BRET / Ikuo Masuho, Kirill A. Martemyanov, and Nevin A. Lambert -- Use of fluorescence indicators in receptor ligands / Kaleeckal G. Harikumar and Laurence J. Miller -- Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging / Michelle L. Halls ... [et al.] -- Measurement of receptor signaling bias / Terry Kenakin -- Approaches to assess functional selectivity in GPCRs : evaluating G protein signaling in an endogenous environment / Laura M. Bohn, Lei Zhou, and Jo-Hao Ho -- Bioluminescence resonance energy transfer approaches to discover bias in GPCR signaling / Elizabeth K. M. Johnstone and Kevin D. G. Pfleger -- Virus-mediated expression of DREADDs for in vivo metabolic studies / Mario Rossi ... [et al.] -- High-throughput screening for allosteric modulators of GPCRs / Robert L. Bertekap Jr. ... [et al.] -- Radioligand binding assay for an exon 11-associated mu opioid receptor target / Gina F. Marrone, Susruta Majumdar, and Gavril W. Pasternak -- Docking and virtual screening strategies for GPCR drug discovery / Thijs Beuming ... [et al.] -- Dynamic process of drug-GPCR binding at either orthosteric or allosteric sites evaluated by metadynamics / Sebastian Schneider, Davide Provasi, and Marta Filizola -- Experiment-guided molecular modeling of protein-protein complexes involving GPCRs / Irina Kufareva, Tracy M. Handel, and Ruben Abagyan -- Interaction fingerprints and their applications to identify hot spots / Andrés F. Marmolejo ... [et al.].
  • 2009 Springer Protocols
    edited by Wayne R. Leifert.
    New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G protein-coupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms [and others] -- GPCR expression using baculovirus-infected Sf9 cells / A.L. Aloia [and others] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert [and others] -- [35S]GTPgammaS binding in G protein-coupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin -- Use of aequorin for G protein-coupled receptor hit identification and compound profiling / S.J. Brough and P. Shah -- BacMam: versatile gene delivery technology for GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. Ames -- Yeast assays for G protein-coupled receptors / S.J. Dowell and A.J. Brown -- GPCR microspot assays on solid substrates / Y. Fang and J. Lahiri -- Resonant waveguide grating biosensor for whole-cell GPCR assays / Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement of GPCR conformational changes / S. Granier [and others] -- FLIPR assays of intracellular calcium in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Use of fluorescence indicators in receptor ligands / K.G. Harikumar and L.J. Miller -- Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation / K.G. Harikumar and L.J. Miller -- Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology / M. Kocan and K.D. Pfleger -- Using reporter gene technologies to detect changes in cAMP as a result of GPCR activation / D.J. Rodrigues and D. McLoughlin -- A quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- Xenopus oocyte electrophysiology in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation and phosphorylation of G protein-coupled receptors / W.G. Thomas.
  • 2014 Springer
    Marta Filizola, editor.
    G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.--Back cover.
    Also available: Print – 2014
  • 2010 Springer
    Jaime M. Monti, S. R. Pandi-Perumal, Hanns Möhler, editors.
    Part 1. Basic Physiology and Pharmacology -- Physiology and Pharmacology of the GABA System: Focus on GABA Receptors / Hanns Möhler -- Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy / John R. Atack -- Distribution of GABAA Receptor Subunits in the Human Brain / H. J Waldvogel, K Baer and R. L. M. Faull -- Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics / David J. Greenblatt -- Part 2. Sleep Science and Circuitry -- Sleep and Its Modulation by Substances That Affect GABAA Receptor Function / Axel Steiger -- Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System / J. Josh Lawrence -- Function of GABAB and ρ-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes / Claude Gottesmann -- Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness / Jaime M. Monti -- GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation / Dinesh Pal and Birendra Nath Mallick -- Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT-PPT) in the Promotion of REM Sleep / Pablo Torterolo and Giancarlo Vanini -- GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site - in the Modulation of Sleep-Wake States / Fernando Reinoso-Suárez, Carmen de la Roza, Margarita L Rodrigo-Angulo, Isabel de Andrés and Ángel Núñez, et al. -- The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep / Gerald A Marks and Christopher M Sinton -- Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms / Daniel P. Cardinali, S. R. Pandi-Perumal, Lennard P. Niles and Gregory M. Brown -- GABA Involvement in the Circadian Regulation of Sleep / J. Christopher Ehlen, Daniel L. Hummer, Ketema N. Paul and H. Elliott Albers -- Part 3. Neurotherapeutics -- Pathophysiology of Sleep Disorders / Thomas C. Wetter, Pierre A. Beitinger, Marie E. Beitinger and Bastian Wollweber -- Insomnia: Differential Diagnosis and Current Treatment Approach / J. F Pagel and Gerald Kram -- Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients / Luc Staner, Françoise Cornette, Sarah Otmani, Jean -François Nedelec and Philippe Danjou -- Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia / Jadwiga S. Najib -- Indiplon / David N. Neubauer -- Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia / Joseph Barbera and Colin Shapiro.
  • 2007 ScienceDirect
    edited by James M. Tepper, Elizabeth D. Abercrombie, J.Paul Bolam.
    Basal ganglia macrocircuits / J. M. Tepper, E. D. Abercrombie and J. P. Bolam -- GABA: homeostatic and pharmacological aspects / A. Schousboe and H. S. Waagepetersen -- GABA [subscript A] receptors: structure and function in the basal ganglia / T. Goetz ... [et al.] -- GABA [subscript B] receptors: structure and function / P. C. Emson -- The cellular, molecular and ionic basis of GABA [subscript A] receptor signalling / M. Farrant and K. Kaila -- GABAergic inhibition in the neostriatum / C. J. Wilson -- Globus pallidus external segment / H. Kita -- Globus pallidus internal segment / A. Nambu -- The pars reticulata of the substantia nigra: a window to basal ganglia output / J. M. Deniau ... [et al.] -- GABAergic control of the subthalamic nucleus / M. D. Bevan, N. E. Hallworth and J. Baufreton -- GABAergic control of substantia nigra dopaminergic neurons / J. M. Tepper and C. R. Lee -- GABAergic output of the basal ganglia / O. Hikosaka -- Localization of GABA receptors in the basal ganglia / J. Boyes and J. P. Bolam -- Presynaptic modulation of GABA release in the basal ganglia / U. Misgeld, G. Drew and Y. Yanovsky -- Development of striatal fast-spiking GABAergic interneurons / M.-F. Chesselet ... [et al.] -- Co-localization of GABA with other neuroactive substances in the basal ganglia / J. F. McGinty -- GABAergic circuits in the basal ganglia and movement disorders / A. Galvan and T. Wichmann -- Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia function / J. R. Wickens, G. W. Arbuthnott and T. Shindou.
  • 2007 Springer
    edited by S.J. Enna and Hanns Möhler.
  • 2014 PsychiatryOnline
    [edited by] Glen O. Gabbard, M. D., Professor of Psychiatry, State University of New York-Upstate Medical University, Syracuse, New York, Clinical Professor of Psychiatry, Baylor College of Medicine, Houston, Texas, Private Practice, The Gabbard Center, Houston, Texas.
    Intellectual disability (intellectual developmental disorder) -- Communication disorders -- Autism spectrum disorder -- Attention-deficit/hyperactivity disorder -- Specific learning disorder -- Tic disorders -- Elimination disorders -- Early-stage schizophrenia -- Toward a dimensional understanding of psychosis and its treatment -- Psychosocial treatments for chronic psychosis -- Pharmacological treatment of psychosis -- Psychotherapy of mood disorders -- Acute and maintenance treatment of bipolar and related disorders -- Pharmacological and somatic treatments for major depressive disorder -- Brain stimulation treatments for mood disorders -- Panic disorder -- Separation anxiety disorder -- Social anxiety disorder (social phobia) -- Generalized anxiety disorder -- Specific phobia -- Obsessive-compulsive disorder -- Body dysmorphic disorder -- Hoarding disorder, trichotillomania (hair-pulling disorder), and excoriation (skin-picking) disorder -- Dissociative identity disorder -- Depersonalization/derealization disorder -- Dissociative amnesia -- Posttraumatic stress disorder -- Acute stress disorder -- Adjustment disorders -- Evidence-based psychological treatments for eating disorders -- Pharmacological treatment of eating disorders -- Intensive treatment for eating disorders -- Primary care and consultation-liaison interventions for somatic symptom and related disorders -- Pharmacological interventions for psychosomatic disorders -- Intensive interventions for somatic symptom disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Paraphilias and paraphilic disorders -- Gender dysphoria -- Oppositional defiant disorder -- Intermittent explosive disorder -- Conduct disorder -- With limited prosocial emotions specifier for conduct disorder -- Pyromania -- Kleptomania -- Alcohol-related disorders -- Sedative-, hypnotic-, or anxiolytic-related disorders -- Opioid-related disorders: opioid detoxification -- Opioid-related disorders: antagonist treatment -- Opioid-related disorders: agonist maintenance treatment -- Hallucinogen-related disorders -- Cannabis-related disorders -- Club drug addiciton -- Stimulant-related disorders -- Nicotine-related disorders -- Individual therapy for substance use disorders -- Cognitive, behavioral, and motivational therapies for substance use disorders -- Group therapy for substance use disorders -- Family therapy in substance abuse treatment -- Network therapy for substance use disorders -- Pain and addiction -- Gambling disorder -- Delirium -- Neurocognitive disorder due to Alzheimer's disease -- Frontotemporal neurocognitive disorder -- Vascular neurocognitive disorder -- Neurocognitive disorder due to Parkinson's disease -- Paranoid, schizotypal, and schizoid personality disorders -- Antisocial personality disorder -- Borderline personality disorder -- Histrionic personality disorder -- Narcissistic personality disorder -- Cluster C personality disorders: avoidant, dependent, and obsessive-compulsive.
  • 2006/2007
    Kuang-Hung Pan.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Dan A. Liebermann, Barbara Hoffman, editors.
    Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.
    Also available: Print – 2013
  • 2010
    Agnieszka Czechowicz.
    Sickle Cell Anemia, Beta Thalassemia, Severe Combined Immunodeficiency (SCID), and Type I Diabetes share one commonality: these diverse disorders can all be attributed to faulty hematolymphoid effector cells which are largely caused by genetic mutations that alter hematopoietic cell-intrinsic function. These defective blood cells inherit their genetic deficiencies from hematopoietic stem cells (HSC) as they differentiate. Thus, each of these unique diseases should be theoretically curable through the same strategy: replacement of patients' HSCs carrying the problematic mutation with normal HSCs from disease-free donors, thereby generating entire new, healthy hematolymphoid systems. Replacement of disease-causing stem cells with healthy ones has been achieved clinically via hematopoietic cell transplantation (HCT) for the last 50 years, as a treatment modality for a variety of cancers and immunodeficiencies with moderate, but increasing success. However this technique bears high morbidity and mortality severely limiting its utilization. Purified hematopoietic stem cell transplantation is associated with high toxicity primarily attributed to the myeloablative pre-conditioning necessary to facilitate engraftment of the donor HSCs. However the function and mechanistic role of these reagents has been up until now poorly understood. This thesis deconstructs the current barriers in HCT and pure HSC transplantation, and suggests that in addition to the immune barrier, hematopoietic stem cell niche availability is another critical obstacle that needs to be overcome to allow for efficient hematolymphoid replacement. In this thesis I show that in the homeostatic state, most hematopoietic stem cell niches are occupied by host HSCs limiting the ability of incoming HSC engraftment. However, a limited number of HSC niches are vacated by HSC that are egressing from the peripheral blood into the bone marrow in a division independent manner, allowing for true but minimal HSC engraftment without myeloablative pre-conditioning. This thesis illustrates new, up-and-coming strategies to combat the obstacle of HSC niche availability. Here I prove that one non-myeloablative conditioning approach that capitalizes upon physiological HSC egress is repetitive transplantation of purified HSCs. However, this approach is rather laborious and inefficient, and I show that another more efficient novel non-myeloablative conditioning approach to vacate the HSC niche is antibody-mediated depletion of host HSCs. Furthermore, in this thesis I demonstrate that antibody-mediated inhibition of c-kit effectively depletes host HSCs and allows for efficient, non-toxic HSC transplantation. These novel non-myeloablative conditioning methods illustrate new means of overcoming the current barriers to hematolymphoid replacement thereby allowing for the potential expansion of this technique to treat a variety of inherited diseases of hematopoietic and immune function.
  • 2007
    Michael W. Whittle.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Jacquelin Perry, Judith M. Burnfield ; illustrated by Lydia M. Cabico.
    Status: Not Checked OutLane Catalog Record
    Gait cycle -- Phases of gait -- Basic functions -- Ankle-foot complex -- Knee -- Hip -- Head, trunk, and pelvis -- Arm -- Total limb function and bilateral synergistic relationships -- Pathological mechanisms -- Ankle and foot gait deviations -- Knee gait deviations -- Hip gait deviations -- Trunk and pelvis gait deviations -- Examples of pathologic gait -- Pediatric gait analysis / Henry G. Chambers -- Stair negotiation -- Running / Marilyn M. Pink -- Gait analysis systems -- Motion analysis -- Muscle control and dynamic electromyography -- Kinetics of gait : ground reaction forces, vectors, moments, power, and pressure -- Stride analysis -- Energy expenditure / Robert Waters.
  • 2011
    Daniel Chávez-Clemente.
    The interest in using legged robots for a variety of terrestrial and space applications has grown steadily since the 1960s. At the present time, a large fraction of these robots relies on electric motors at the joints to achieve mobility. The load distributions inherent to walking, coupled with design constraints, can cause the motors to operate near their maximum torque capabilities or even reach saturation. This is especially true in applications like space exploration, where critical mass and power constraints limit the size of the actuators. Consequently, these robots can benefit greatly from motion optimization algorithms that guarantee successful walking with maximum margin to saturation. Previous gait optimization techniques have emphasized minimization of power requirements, but have not addressed the problem of saturation directly. This dissertation describes gait optimization techniques specifically designed to enable operation as far as possible from saturation during walking. The benefits include increasing the payload mass, preserving actuation capabilities to react to unforeseen events, preventing damage to hardware due to excessive loading, and reducing the size of the motors. The techniques developed in this work follow the approach of optimizing a reference gait one move at a time. As a result, they are applicable to a large variety of purpose-specific gaits, as well as to the more general problem of single pose optimization for multi-limbed walking and climbing robots. The first part of this work explores a zero-interaction technique that was formulated to increase the margin to saturation through optimal displacements of the robot's body in 3D space. Zero-interaction occurs when the robot applies forces only to sustain its weight, without squeezing the ground. The optimization presented here produces a swaying motion of the body while preserving the original footfall locations. Optimal displacements are found by solving a nonlinear optimization problem using sequential quadratic programming (SQP). Improvements of over 20% in the margin to saturation throughout the gait were achieved with this approach in simulation and experiments. The zero-interaction technique is the safest in the absence of precise knowledge of the contact mechanical properties and friction coefficients. The second part of the dissertation presents a technique that uses the null space of contact forces to achieve greater saturation margins. Interaction forces can significantly contribute to saturation prevention by redirecting the net contact force relative to critical joints. A method to obtain the optimal distribution of forces for a given pose via linear programming (LP) is presented. This can be applied directly to the reference gait, or combined with swaying motion. Improvements of up to 60% were observed in simulation by combining the null space with sway. The zero-interaction technique was implemented and validated on the All Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE), a hexapod robot developed by NASA for the transport of heavy cargo on the surface of the moon. Experiments with ATHLETE were conducted at the Jet Propulsion Laboratory in Pasadena, California, confirming the benefits predicted in simulation. The results of these experiments are also presented and discussed in this dissertation.
  • 2008 Springer
    Carl C. Gaither and Alma E. Cavazos-Gaither.
    v. 1. Abortion-medical science -- v. 2. Medicine and art--zoology.
  • 2010 Springer
    Tomas Hökfelt, editor.
    Galanin : a multitalented neuropeptide / T. Hökfelt and K. Tatemoto -- Galanin, galanin receptors, and drug targets / K. Mitsukawa, X. Lu, and T. Bartfai -- Galanin acts as a trophic factor to the central and peripheral nervous systems / S-A. Hobson ... [et al.] -- Galanin and spinal pain mechanisms : past, present, and future / Xiao-Jun Xu, Tomas Hökfelt, and Zsuzsanna Wiesenfeld-Hallin -- Galanin family of peptides in skin function / J.W. Bauer ... [et al.] -- Galanin in glia : expression and potential roles in the CNS / Helmut Butzkueven and Andrew L. Gundlach -- Galanin and the neuroendocrine axes / Istvan Merchenthaler -- Galanin and consummatory behavior : special relationship with dietary fat, alcohol, and circulating lipids / Jessica R. Barson, Irene Morganstern, and Sarah F. Leibowitz -- Neurochemical modulation of central cardiovascular control : the integrative role of galanin / Zaida Díaz Cabiale ... [et al.] -- Galanin impairs cognitive abilities in rodents : relevance to Alzheimer's disease / J.N. Crawley -- Neuroprotective role for galanin in Alzheimer's disease / Scott E. Counts ... [et al.] -- Galanin, galanin receptor subtypes, and depression-like behaviour / Eugenia Kuteeva ... [et al.] -- Galanin and epilepsy / J.T. Lerner, R. Sankar, and A.M. Mazarati -- Galanin and addiction / Marina R. Picciotto -- Galanin systems and ischemia : peptide and receptor plasticity in neurons and oligodendroglial precursors / Pei-Juan Shen and Andrew L. Gundlach -- The galanin system in cancer / I. Rauch and Barbara Kofler -- Galanin systems in non-mammalian vertebrates with special focus on fishes / Elsie Tachie Mensah, Helene Volkoff, and Suraj Unniappan -- Galanin-like peptide : neural regulator of energy homeostasis and reproduction / Catherine B. Lawrence and Gregory S. Fraley.
  • 2015 Springer Protocols
    edited by Sean R. Stowell, Richard D. Cummings.
    Evolving mechanistic insights into galectin functions / Connie M. Arthur [and three others] -- Cloning, expression, and purification of galectins for in vitro studies / Paul A. Poland, Carol L. Kinlough, and Rebecca P. Hughey -- Alkylation of galectin-1 with iodoacetamide and mass spectrometric mapping of the sites of incorporation / Sean R. Stowell [and three others] -- Evaluation of galectin binding by frontal affinity chromatography (FAC) / Jun Iwaki and Jun Hirabayashi -- Probing lectin-mucin interactions by isothermal titration microcalorimetry / Tarun K. Dam and C. Fred Brewer -- Examination of whole cell galectin binding by solid phase and flow cytometric analysis / Anne Leppänen, Connie M. Arthur, Sean R. Stowell, and Richard D. Cummings -- Evaluation of galectin binding by surface plasmon resonance / Padmaja Mehta-D'souza -- Examining galectin binding specificity using glycan microarrays / Connie M. Arthur [and seven others] -- Methods for assessing the effects of galectins on leukocyte trafficking / Beatrice R. Gittens, Rachael D. Wright, and Dianne Cooper -- Examination of the role of galectins in plasma cell differentiation / Chih-Ming Tsai and Kuo-I Lin -- Examination of galectin-induced lattice formation on early B-cell development / Stéphane J.C. Mancini [and five others] -- Detection of phosphatidylserine exposure on leukocytes following treatment with human galectins / Connie M. Arthur [and five others] -- Examination of galectins in phagocytosis / Huan-Yuan Chen [and four others] -- Assessing the roles of galectins in regulating dendritic cell migration through extracellular matrix and across lymphatic endothelial cells / Sandra Thiemann, Jeanette H. Man, and Linda G. Baum -- Examination of the role of galectins in intestinal inflammation / Atsushi Nishida, Cindy W. Lau, and Atsushi Mizoguchi -- Study of galectins in tumor immunity : strategies and methods / Juan P. Cerliani [and seven others] -- Galectins in the regulation of platelet biology / Maria A. Romaniuk, Gabriel A. Rabinovich, and Mirta Schattner -- Examination of the role of galectins and galectin inhibitors in endothelial cell biology / Iris A. E. Schulkens [and four others] -- Regulation of galectins by hypoxia and their relevance in angiogenesis : strategies and methods / Mariana Salatino [and ten others] -- Examination of the role of galectins during in vivo angiogenesis using the chick chorioallantoic membrane assay / Esther A. Kleibeuker [and four others] -- Examination of the role of galectins in cell migration and re-epithelialization of wounds / Zhiyi Cao [and three others] -- Manipulating galectin expression in Zebrafish (Danio rerio) / Chiguang Feng [and seven others] -- Examination of galectin localization using confocal microscopy / Daniel Giuliano Cerri [and six others] -- Examination of the regulation of galectin-3 expression in cancer / Hafiz Ahmed and Gargi Bandyopadhyaya -- Evaluation of the role of galectins in parasite immunity / Sarah Preston [and four others] -- Effect of galectins on viral transmission / Michel Ouellet [and three others] -- Evaluation of the bactericidal activity of galectins / Connie M. Arthur, Richard D. Cummings, and Sean R. Stowell -- Examination of the role of galectins in pre-mRNA splicing / Ronald J. Patterson [and three others] -- Analysis of the intracellular role of galectins in cell growth and apoptosis / Daniel K. Hsu [and three others] -- Nucleocytoplasmic shuttling of galectin-3 / Eric J. Arnoys, Cheri M. Ackerman, and John L. Wang.
  • [commentary by] Glen M. Cooper.
  • 2014 Springer
    He-Feng Huang, Jian-Zhong Sheng, editors.
    The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians.
  • 2013 Springer
    Tiziana A.L. Brevini, Georgia Pennarossa.
    This Brief offers a concise, handy overview of the main concepts related to Embryology, revisited through the novel concepts that are applied daily in stem cell research and cell therapy oriented investigations. It is based on three main areas: -The process involved in female gamete differentiation and maturation. The main aspects related to cell biology will be covered and an overview of the epigenetic regulation of gametogenesis will be presented. -Early stages of embryo development with a careful analysis of the regulatory mechanisms driving cleavage, polarization and genome activation. -Stem cell and gametogenesis. The use of the oocyte as a possible source for the derivation of stem cell lines is discussed and depicted as a powerful tool to investigate oocyte potency and asymmetric imprinting. The potential biological implications are evaluated and use of stem cells to derive oocytes is presented.
  • 2011 Springer
    Jeremy C. Ganz.
    Introduction and the nature of radiosurgery -- Principles of stereotaxy -- Ionizing radiation and its effects on living tissue -- Biological effects of ionizing radiation -- Ionizing radiation and clinical practice -- Gamma knife development from 1967 to 2010 -- Radiophysics, radiobiology and the gamma knife -- Preparation for treatment planning -- Dose plan indices -- Gamma knife surgery and computer networks -- Aims of gamma knife surgery -- Principles of information and follow up -- Vestibular schwannomas -- Meningiomas -- Gamma knife for cerebral metastases -- Intraparenchymal intrinsic brain tumors -- Tumors of the pituitary region -- Less common skull base tumors -- Gamma knife for cerebral vascular anomalies -- Trigeminal neuralgia -- Diverse functional indications -- Rare tumors and other lesions -- Orbital indications -- Conclusion and possible future trends.
  • 2013 Springer
    edited by Mikhail F. Chernov, Motohiro Hayashi, Jeremy C. Ganz, Kintomo Takakura.
    The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.
  • 2013 Karger
    volume editors, Ajay Niranjan, Hideyuki Kano, L. Dade Lunsford.
    A brief history of arteriovenous malformation radiosurgery / A. Niranjan, L.D. Lunsford -- Natural history of cerebral arteriovenous malformations and the risk of hemorrhage after radiosurgery / C.-P. Yen, D. Schlesinger, J.P. Sheehan -- The technical evolution of gamma knife radiosurgery for arteriovenous malformations / L.D. Lunsford ... [et al.] -- Targeting and conformality in arteriovenous malformation radiosurgery / I. Paddick, E. Motti -- Dose selection in stereotactic radiosurgery / J.C. Flickinger ... [et al.] -- Development and testing of a radiosurgery-based arteriovenous malformation grading system B.E. Pollock -- Radiosurgery for brainstem arteriovenous malformation / K. Maruyama ... [et al.] -- Multistaged volumetric management of large arteriovenous malformations / H. Kano -- Endovascular embolization in combination with radiosurgery for treatment of arteriovenous malformations / R.A. Miller, B. Jankowitz -- Stereotactic radiosurgery after embolization for arteriovenous malformations / H. Kano -- Long-term side effects of radiosurgery for arteriovenous malformations / M. Yamamoto, T. Kawabe, B.E. Barfod -- Management of adverse radiatio effects after radiosurgery for arteriovenous malformations / E.A. Monaco -- Morphological observations in brain arteriovenous malformations after gamma knife radiosurgery / G.T. Szeifert -- Stereotactic radiosurgery guideline for the management of patients with intracranial arteriovenous malformations / A. Niranjan, L.D. Lunsford -- Cavernous malformations and hemorrhage risk / D. Kondziolka, E.A. Monaco, III, L.D. Lunsford -- Radiosurgery of brain cavernomas : long-term results / R. Liscak -- Radiosurgical treatment for epilepsy associated with cavernomas / M. Lévêque -- Stereotactic radiosurgery guidelines for the management of patients with intracranial cavernous malformations / A. Niranjan, L.D. Lunsford -- Intracranial dural arteriovenous fistulas : natural history and rationale for treatment with stereotactic radiosurgery / D.H.-C. Pan ... [et al.] -- Stereotactic radiosurgery with or without embolization for intracranial dural arteriovenous fistulas / H. Yang -- Dural arteriovenous fistulas and the role of gamma knife stereotactic radiosurgery : the Stockholm experience / M. Söderman, E. Dodoo, B. Karlsson -- Stereotactic radiosurgery guidelines for the management of patients with intracranial dural arteriovenous fistulas / A. Niranjan, L.D. Lunsford.
  • 2001 Karger
    volume editors, Paul R. Bergstresser, A. Takashima.
    T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotection
    Also available: Print – 2001
  • 2013 Springer
    Immacolata Castellano, Antonello Merlino.
    Gamma-Glutamyl Transpeptidases (g-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the g-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released g-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). g-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.g-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of g-GTs and gives information about applications of g-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
  • v. 1, 1966.
    Section editor: A. G. Karczmar.
    Status: Not Checked OutLane Catalog Record
    v. 1. Muscarinic and nicotinic stimulant actions at autonomic ganglia, by R. L. Volle.
  • 2013
    [edited by] James W. Myers, Jonathan P. Moorman, Cassandra D. Salgado.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Norbert W. Seidler.
    Also available: Print – 2013
  • 2015 Springer
    Kazunori Kihara, editor.
    Chapter 1. Fundamentals of Gasless Single-Port RoboSurgeon Surgery -- Chapter 2. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Nephrectomy -- Chapter 3. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Partial Nephrectomy -- Chapter 4. Gasless Two-Port Access RoboSurgeon Retroperitoneoscopic Radical Nephroureterectomy -- Chapter 5. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Adrenalectomy -- Chapter 6. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Prostatectomy -- Chapter 7. Gasless Single-Port RoboSurgeon Total Cystectomy with Urinary Diversion -- Chapter 8. Gasless Single-Port RoboSurgeon Partial Cystectomy: A Hybrid Technique Combining an Intravesical and Extravesical approach -- Chapter 9. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Pelvic Lymph Node Dissection and Inguinal Hernia Prevention -- Chapter 10. Application of the RoboSurgeon System in Medical Care.
  • 2012 Springer
    Anton Hermann, Guzel F. Sitdikova, Thomas M. Weiger, editors.
    "The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters."--P. [4] of cover.
  • v.1-2=, 2012 ClinicalKey
    Anita Agarwal.
    v. 1. Normal macula -- Imaging and electrophysiological studies -- Diseases causing exudative and hemorrhagic detachment of the choroid, retina and retinal pigment epithelium -- Folds of the choroid and retina -- Heredodystrophic disorders affecting the pigment epithelium and retina -- Macular dysfunction caused by retinal vascular diseases -- Macular dysfunction caused by vitreous and vitreoretinal interface abnormalities -- Traumatic retinopathy -- v. 2. Toxic diseases affecting the pigment epithelium and retina -- Infectious diseases of the retina and choroid -- Inflammatory diseases of the retina -- Tumors of the retinal pigment epithelium (RPE) -- Neoplastic diseases of the retina -- Neoplastic diseases of the choroid -- Optic nerve diseases that may masquerade as macular diseases.
  • 2015 Springer
    Vivian E. Strong, M.D., F.A.C.S., editor.
    The Historical Perspective of Gastric Cancer -- Epidemiology of Gastric Cancer -- Molecular Mechanisms in Gastric Carcinogenesis -- Pathology of Gastric Cancer -- Role of HER2 in Gastric Cancers -- Pathophysiology of Hereditary Diffuse Gastric Cancer -- Western Perspective and Epidemiology of Gastric Cancer -- Diagnosis, Staging and Workup of Gastric Cancer -- Endoscopy and Endoscopic Ultrasound Examination of the Stomach -- The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer -- Endoscopic Resection for Gastric Cancer -- Methods of Reconstruction -- BI, BII, Roux-en-Y, Jejunal Interposition, Proximal Gastrectomy and Pouch Reconstruction -- Lymphadenectomy -- D1, D2 and D3 -- Open Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy -- Laparoscopic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Robotic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Managing Early and Late Postoperative Complications Following Gastric Surgery -- Hereditary Diffuse Gastric Cancer -- Surveillance after Gastric Resection -- Surgical Trials for Gastric Cancer -- Neoadjuvant and Adjuvant Treatment -- Strategies and Clinical Trials -- Western Perspective -- Adjuvant and Neoadjuvant Treatment: Standard Treatment and Clinical Trials in the East -- Radiation Treatment for Gastric Cancer -- Targeted Therapy and Novel Agents for the Treatment of Gastric Cancer: A View towards the Future.
  • 2012 ScienceDirect
    2012 ClinicalKey
    [edited by] Josef Neu ; consulting editor, Richard A. Polin.
    Overview of digestion and absorption / Josef Neu -- Maturation of motor function in the preterm infant and gastroesophageal reflux / Anna Marla Hibbs -- Development of gastrointestinal motility reflexes / Sudarshan Rao Jadcherla -- Development of the intestinal mucosal barrier / Allan Walker and Camilia Martin -- The developing intestinal microbiome and its relationship to health and disease / Josef Neu -- The developing intestine as an immune organ / Patricia Lin -- The developing gastrointestinal tract in relation to autoimmune disease, allergy, and atopy / Outi Vaarala -- What are the controversies for basic intestinal development and where will the field be moving in the future? / Josef Neu -- Nutritional requirements of the very-low-birthweight infant / Patti Thureen and William Hay Jr. -- Controversies in neonatal nutrition : macronutrients and micronutrients / Frank R. Greer -- Regulation of protein synthesis and proteolysis in the neonate by feeding / Tracy Gautsch Anthony and Susan Hazels Mitmesser -- Lipids for neonates / Sheila M. Innis -- Human milk feeding of the high-risk neonate / Christina Valentine -- Nutritional requirements for the neonate : what are the controversies and where will the field be moving in the future? / Josef Neu -- Necrotizing enterocolitis / Josef Neu -- Special nutrition of the surgical neonate / Tom Jaksic -- Controversies in short bowel syndrome / Marc Rhoads -- Neonatal cholestasis / Joel Andres -- The neonatal gastrointestinal tract as a conduit to systemic inflammation and developmental delays / Josef Neu and James Wynn -- Adult consequences of neonatal and fetal nutrition : mechanisms / Robert Lane -- Technologies for the evaluation of enteral feeding readiness in premature infants / Josef Neu -- What are the controversies for these clinical conditions and where will the field be moving in the future? / Josef Neu.
  • 2013 Springer
    Keith C. Meyer, Ganesh Raghu, editors.
    Deglutition, Swallowing, and Airway Protection: Physiology and Pathophysiology / Jacqui E. Allen -- The Pathophysiology of Gastroesophageal Reflux / Nikki Johnston -- Making an Accurate Diagnosis of GERD / Edward D. Auyang and Brant K. Oelschlager -- GER and Aspiration in Children / Jonathan E. Spahr and Raymond C. Maguire -- Dysphagia, GER, and Aspiration in the Elderly / Joshua Malo, Kenneth S. Knox and Ronnie Fass -- Chronic Cough and Vocal Cord Dysfunction: The Role of GER / Jamal Hayat, Etsuro Yazaki and Daniel Sifrim -- GER in Asthma and COPD / Bindu Akkanti and Nicola A. Hanania -- Sleep and GER / Susan M. Harding -- Gastroesophageal Reflux in Cystic Fibrosis and Non-CF Bronchiectasis / Ans Pauwels, Daniel Sifrim and Lieven Dupont -- GER and Aspiration in Interstitial Lung Disease / Keith C. Meyer and Ganesh Raghu -- GER in Lung Transplantation / Keith C. Meyer and James D. Maloney -- Pharmacologic Treatment of GERD / Eric Alan Gaumnitz -- Surgical and Endoscopic Approaches to GERD / Marcelo W. Hinojosa and Carlos A. Pellegrini.
  • 2006 Springer
    Frank A. Granderath, Thomas Kamolz, Rudolph Pointner, eds.
  • 2007
    edited by Chandra M. Kumar, Mark Bellamy.
    Status: Not Checked OutLane Catalog Record
  • 2012 CRCnetBASE
    edited by Gerard E. Mullin, Laura E. Matarese, Melissa Palmer.
    "Presents the nutritional consequences and considerations of digestive disorders. Examines the role of nutrition in gastrointestinal and liver disease, including alcoholic and nonalcoholic liver disease, viral hepatitis, cirrhosis, malabsorption, colorectal disease, transplantation, pancreatitis, and inflammatory bowel disease. Includes chapters on food allergy and intolerance, the effects of medicinal plants, and the role of fiber in the gastrointestinal tract. Addresses the challenges of managing nutritional issues for hospitalized patients, and covers eating disorders and ethical issues."--Excerpted from abstract provided by publisher.
  • 2012 ClinicalKey
    edited by Christine A. Iacobuzio-Donahue, Elizabeth Montgomery.
    Non-neoplastic disorders of the esophagus -- Tumors of the esophagus -- Non-neoplastic disorders of the stomach -- Epithelial neoplasms of the stomach -- Non-neoplastic and inflammatory disorders of the small bowel -- Neoplasms of the small intestine -- Gastrointestinal mesenchymal tumors -- Non-neoplastic and neoplastic disorders of the appendix -- Infectious diseases of the colon -- Idiopathic inflammatory bowel disease -- Inflammatory/descriptive/iatrogenic colitides -- Gastrointestinal polyposis syndromes -- Epithelial neoplasms of the colorectum -- Molecular diagnostics in gastrointestinal pathology -- Pathology of the anus -- Pathology of the gallbladder and extrahepatic bile ducts -- Non-neoplastic and neoplastic pathology of the pancreas -- Metabolic and toxic conditions of the liver -- Inflammatory and infectious diseases of the liver -- Liver neoplasms -- Gastrointestinal lymphoma.
  • 2010 Springer
    Aurora D. Pryor, Theodore N. Pappas, Malcolm Stanley Branch, editors.
    Part 1. Upper GI Bleeding -- Stabilization of Patients Presenting with Upper Gastrointestinal Bleeding / Errol L. Bush and Mark L. Shapiro -- Urgent Workup for Upper Gastrointestinal Bleeding / Loretta Erhunmwunsee and Sandhya A. Lagoo-Deenadayalan -- Management of Esophageal Variceal Bleeding / Keki Balsara and Lisa Pickett -- Management of Dieulafoy's Lesions / Seraina K. Faes, Brian R. Untch, Claire Edwards, John Turner and Martin Poleski, et al. -- Management of Bleeding Peptic Ulcer Disease / James C. Padussis and Theodore N. Pappas -- Management of Unusual Sources of Upper GI Bleeding / Elisabeth Tracy and Janet Tuttle-Newhall -- Mallory-Weiss Syndrome / Jacob N. Schroder and Malcolm S. Branch -- Management of Bleeding Small Bowel Tumors / Keri E. Lunsford and Aurora D. Pryor -- Management of Bleeding from the Bile Duct / Carlos E. Marroquin and Bridget M. Marroquin -- Management of Bleeding from the Pancreas / Eugene P. Ceppa and Dana Portenier -- Part 2. Lower GI Bleeding -- Urgent Workup of Lower GI Bleeding / Dawn M. Emick and Leila Mureebe -- Bleeding Hemorrhoids / Kelley A. Hutcheson and Danny O. Jacobs -- Management of Bleeding Colitis and Colonic Diverticular Disease / Sebastian G. de la Fuente, Hardeep S. Ahluwalia, Alex Perez and John Migaly -- Colonic Arteriovenous Malformations / Sebastian G. de la Fuente and Christopher R. Mantyh -- Bleeding Colonic Tumors / Vanessa A. Olcese and Christopher R. Mantyh -- Part 3. GI Bleeding from an Unknown Source -- Evaluation of the Guaiac Positive Patient / Rebecca Burbridge and Melissa Teitelman -- Obscure GI Bleeding: Capsule and Double-Balloon Techniques / Stephen Philcox -- Provocative Angiography / Mayur B. Patel, Charles Y. Kim and Michael J. Miller -- The Unstable Patient with Obscure Gastrointestinal Bleeding: Surgical and Non-surgical Management / Rebecca P. Petersen and Aurora D. Pryor .
  • 2005 Springer
    Jaffer A. Ajani, Steven A. Curley, Nora A. Janjan ... [et al.] editors ; foreword by James L. Abbruzzese and Raphael E. Pollock.
    Also available: Print – 2005
  • 2009 Springer
    Rikiya Fujita, Hiroshi Takahashi, eds.
  • 2008 Springer
    edited by M.A. Hayat.
  • 2015 Springer
    Sreenivasa S. Jonnalagadda, editor.
    This comprehensive treatise on cutting edge tools and research provides a fascinating insight into the rapidly evolving field of diagnostic and therapeutic endoscopy. Accomplished international researchers and clinicians discuss the latest endoscopic advances in diverse areas including obesity and associated metabolic syndromes, management of peripancreatic fluid collections, endoluminal suturing techniques, fistula closure, management of Barrettℓ́ℓs epithelium, cholangioscopy, chromoendoscopy, high resolution manometry and endoscopic ultrasonography. Gastrointestinal Endoscopy: New Technologies and Changing Paradigms is a valuable resource on the evolving role of endoscopic management of gastrointestinal diseases and is a tremendous resource for gastroenterologists, endoscopists, GI surgeons, and medical residents.
  • 2011 ScienceDirect
    2011 ClinicalKey
    edited by Jean Marc Canard, Jean-Christophe Létard, Laurent Palazzo, Ian Penman, Anne Marie Lennon.
    Introduction to endoscopy -- Preparation for Endoscopy -- Diagnostic Upper Endoscopy -- 4 Diagnostic Colonoscopy -- 5 Small Bowel Endoscopy: Indications and Technique -- Advanced Imaging -- Interventional Endoscopy -- Complications of Gastrointestinal Endoscopy -- Endosonography -- Endoscopic Retrograde Cholangiopancreatography.
  • 2013 Wiley
    edited by John Deutsch, Matthew R. Banks.
    pt. 1. Introduction to endoscopy -- pt. 2. Esophagus -- pt. 3. Stomach -- pt. 4. Small bowel -- pt. 5. Pancreatic -- pt. 6. Gallbladder, bile duct, and ampulla of vater biliary, gallbladder, and ampullary lesions -- pt. 7. Hepatic tumors (including intrahpetic cholangiocarcinoma) -- pt. 8. Colorectal and anal tumors -- pt. 9. Gastrointestinal endoscopic management of tumors not of GI origin -- role of GI endoscopy.
  • 2008 Thieme Book
    Hans-Juergen Brambs.
    Liver -- Gallbladder and biliary tract -- Pancreas -- Gastrointestinal tract (general) -- Esophagus -- Stomach and duodenum -- Small bowel -- Colon and anus -- Abdominal cavity.
  • 2011 Thieme Book
    edited by Jonathan Lorenz.
    Indhold: RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical. Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment.Each case begins with the clinical presentation on the right-hand page; simply turn the page for imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more. Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book's specialty - 250 cases in total.
  • 2008
    Robert D. Halpert.
    Status: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    Giles W. L. Boland.
    Get the essential tools you need to make an accurate diagnosis with Gastrointestinal Imaging, 4th Edition! Edited by Giles W. Boland, MD, this popular volume in The Requisites Series delivers the conceptual, factual, and interpretive information you need for effective clinical practice in gastrointestinal imaging. Master core knowledge the easy and affordable way with clear, concise text; new, high-quality images, and coverage of the latest modalities. Efficiently and affordably prepare for the written board exam and for clinical practice with focused, high-yield, richly illustrated coverage of the most essential concepts in gastrointestinal imaging.
  • 2006
    Robert D. Halpert.
    Status: Not Checked OutLane Catalog Record
  • 2012 ClinicalKey
    Vincent H.S. Low.
    Gastrointestinal Imaging: Case Review, by Vincent Low, MD, FRANZCR, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this medical reference title in the popular Case Review series features - 200 cases - organized by difficulty - and 400 images available online at www.casereviewsonline.com, with questions and answers, diagnoses, commentary, and references. It is ideal for quick reference and easy board review! Study effectively with content that mimics the new format of board exams as well as the everyday clinical experience - offering highly effective preparation for certification, recertification, and practice. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty and then by body part within each category. Stay current with the most recent findings and advancements in gastrointestinal radiology.
  • FRANZCR, Vincent Low.
    Status: Not Checked OutLane Catalog Record
  • Halpert, Robert D.
    Status: Not Checked OutLane Catalog Record
  • Lorenz, Jonathan.
    Status: Not Checked OutLane Catalog Record
  • 2016 Springer
    edited by David Bentrem, Al B. Benson.
    Gastric and small bowel tumors / L. Mark Knab, Anthony Yang -- Pathologic features of esophageal and gastric malignancies / Eduard Matkovic, Michael Schwalbe, Kristina A. Matkowskyj -- Pathologic features of miscellaneous foregut malignancies / Eduard Matkovic, Michael Schwalbe, Kristina A. Matkowskyj -- Management controversies and treatment strategies for borderline resectable pancreatic cancer / Mark S. Talamonti -- Pathologic features of primmary pancreatic malignancies / Ashley M. Cunningham, Patrick S. Rush, Kristina A. Matkowskyj -- Gall bladder cancer / Audrey E. Ertel, David Bentrem, Daniel E. Abbott -- Diagnosis and management of intrahepatic and extrahepatic cholangiocarcinoma / Jason Ho, Steven A. Curley -- Hepatocellular carcinoma: surgical management and evolving therapies / Olga Kantor, Marshall S. Baker -- Clinical features of metastatic hepatic malignancies / Ramiro Fernandez, Sam G. Pappas, David J. Bentrem -- Repeat hepatectomy for colorectal liver metastases / Vikrom Dhar, Ryan M. Thomas, Syed A. Ahmad -- Minimally invasive surgery of the liver / Michael White, Yuman Fong, Laleh Melstrom -- Locoregional therapies for primary and secondary hepatic malignancies / Ahsun Riaz, Robert J. Lewandowski, Riad Salem -- Pathologic features of primary and metastatic hepatic malignancies / Kristina A. Matkowskyj, M. Sambasiva Rao, Guang-Yu Yang -- Robotic rectal cancer surgery / Kurt Melstrom -- Pathologic features of primary colon, rectal, and anal malignancies / Kaitlin E. Sundling, Ranran Zhang, Kristina Matkowskyj -- Importance of adequate lymphadenectomy in gastrointestinal cancer / Andrew Benjami, Ryan P. Merkow -- Circulating tumor cells in gastrointestinal cancer: current practices anbd future directions / Colin M. Court, Jacob S. Ankeny, Shonan Sho, James S. Tomlinson -- Cost-effectiveness analysis in cancer care / Alex Chang, Daniel E. Abbott -- Gastrointestinal malignancy: genetic implications to clinical applications / Nicole E. Lopez, Jen Jen Yeh.
    Also available: Print – 2016
  • 2011 Springer
    Charles D. Blanke, Claus Rödel, Mark S. Talamonti, (editors).
    PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Bénard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
  • 2008 Ovid
    Cecilia M. Fenoglio-Preiser, Amy E. Noffsinger, Grant N. Stemmermann, Patrick E. Lantz, Peter G. Isaacson.
    General features of the gastrointestinal tract and evaluation of specimens derived from it -- The nonneoplastic esophagus -- The neoplastic esophagus -- The nonneoplastic stomach -- The neoplastic stomach -- The nonneoplastic small intestine -- Epithelial tumors of the small intestine -- Nonneoplastic diseases of the appendix -- The neoplastic appendix -- Motility disorders -- Inflammatory bowel disease -- Polyposis and hereditary cancer syndromes -- The nonneoplastic colon -- Epithelial neoplasms of the colon -- The nonneoplastic anus -- Neoplastic lesions of the anus -- Gastrointestinal neuroendocrine lesions -- Lymphoproliferative disorders of the gastrointestinal tract -- Mesenchymal tumors.
    Also available: Print – 2008
  • 2006 AccessMedicine
    Kim E. Barrett.
    Functional anatomy of the GI tract and organs draining into it -- Neurohumoral regulation of gastrointestinal function -- Gastric secretion -- Pancreatic and salivary secretion -- Water and electrolyte absorption and secretion -- Intestinal mucosal immunology and ecology -- Esophageal motility -- Gastric motility -- Intestinal motility -- Functional anatomy of the liver and biliary system -- Bile formation and secretion -- Gallbladder function -- Bilirubin formation and excretion by the liver -- Ammonia and urea -- Carbohydrate, protein and water soluble vitamin assimilation -- Lipid assimilation.
  • 2014 Springer
    Eugene Trowers, Marc Tischler.
    This volume provides a practical hands on guide to gastrointestinal physiology. The book emphasizes an appreciation of basic physiological concepts and their application to novel clinical situations. It exposes the physician-in-training to fundamental principles that are useful in treating patients and lays the groundwork for more advanced study in the future. The authors present relevant cases which incorporate newer adult learning strategies in medical education. These cases provide a forum in which the student can apply acquired knowledge, skills and attitudes. Connections are made to reader's life, whether in the classroom, on the wards or out and about town. Designed for medical students who are studying gastrointestinal physiology for the first time, Gastrointestinal Physiology: A Clinical Approach provides a superb review for upper level medical students and house officers. Nursing and allied health professions students will also find this text to be a useful guide. GI fellows and attending physicians in need of a concise review of fundamental GI physiology principles will also benefit from reading this book.
  • 2013 ClinicalKey
    Leonard R. Johnson.
    Gastrointestinal Physiology, a volume in the Mosby Physiology Monograph Series, explains the fundamentals of gastrointestinal physiology in a clear and concise manner. Ideal for your systems-based curriculum, this fully updated medical textbook provides you with a basic understanding of how the GI system functions in both health and disease. New to this edition: Stay abreast of the latest research and findings in physiology with coverage of the physiological significance of gastrointestinal peptides; the regulation of mucosal growth and cancer; details surrounding acid secretion and peptic ulcers; and more. Access new gastrointestinal information on the regulation of pancreatic secretion and gallbladder contraction; the transport processes for the absorption of nutrients; facts about fat absorption; and the regulation of food intake.
    Also available: Print – 2014
  • 2014 AccessMedicine
    Kim E. Barrett.
    Gastrointestinal Physiology explains the operation and performance of one of the body's most crucial systems. Using clear, compelling language, the book's presentation makes it easy to absorb the content and integrate it as you learn the physiology of other bodily systems. Written to help you understand essential concepts rather than merely memorize facts, this unique text examines many medically relevant facets of this important body system, including anatomy, pathophysiology, and therapeutics, in concert with physiological information.
  • 2007
    edited by Leonard R. Johnson.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Timothy M. Pawlik, Shishir K. Maithel, Nipun B. Merchant, editors.
    Tracheo-esophageal Fistula -- Esophageal strictures refractory to endoscopic dilatation -- Esophgeal anastomotic leak -- Transhiatal esophagectomy: intraoperative disasters -- Chyle leak after esophageal surgery -- Management of airway, hoarseness and vocal cord dysfunction after esophagectomy -- Severe reflux induced esophagitis -- Introperative solutions for gastric conduit that will not reach -- Injury to the right gastroepiploic artery -- Intraoperative solutions for ischemic gastric conduit -- Jejunal feeding tube complications -- Bile reflux and gastroparesis -- Gastric surgery: dealing with dumping syndrome -- Afferent loop syndrome -- Duodenal stump blowout -- Postoperative complications after surgery for gastric cancer: Anastomotic leakage -- Hepatobiliary and pancreatic surgery: postoperative hepatic insufficiency -- Biliary leaks and thoracobiliary fistula -- Contralateral bile duct injury during hepatic resection -- Massive Intra-operative Hemorrhage During Hepato-Biliary and Pancreatic Surgery -- Hepatobiliary and Pancreatic Surgery: Intraoperative injury to Hepatic Arterial Structures -- Hepatobiliary and pancreatic surgery: hepatic abscess -- Hepaticojejunostomy anastomotic strictures -- Stricture at Pancreatico-Jejunostomy or Pancreatico-Gastrostomy -- Postoperative Portal, Mesenteric and Splenic Vein Thrombosis -- Post-pancreatectomy Hemorrhage: Early and Late -- Major Disruptions of Pancreaticojejunostomy -- Persistent Pancreatic Fistula -- Management of Chyle Leaks Following Pancreatic Resection -- Hepatobiliary and Pancreatic Surgery: Preventing Pancreatic Fistula following Distal Pancreatectomy -- Pearls for the Small Bowel and Colon That Will Not Reach -- Anastomotic Leak / Pelvic Abscess -- Management of Anastomotic Stricture -- Colorectal Surgery: Intraoperative Ureteral Injury -- Colorectal surgery: Prostatic Urethral Injury -- Vaginal Injury During Stapled -- Anastomosis -- Management of rectovaginal fistula -- Management of Presacral / Pelvic Bleeding -- Breakdown / Nonhealing of Perineal Wound -- Complications after TEM (Transanal Endoscopic Microsurgery) and TAMIS Maria -- Parastomal hernia -- Stoma Retraction/Ischemia/Stenosis -- Incontinence after Lateral Internal Sphincterotomy/ Fistulotomy -- Anal Stenosis after Hemorrhoidectomy: Avoidance and Management -- Delivering Bad News: Conversations with My Surgeon.
  • 2008 Springer
    [edited by] A. Couture ... [et al.] ; with contributions by C. Baud ... [et al.] ; foreword by F. Avni.
  • 2012 Springer
    Henry P. Parkman, Richard W. McCallum, editors.
  • 2012
    Xiao Xu.
    Stress is a fundamental aspect of aging as accumulated damage from a lifetime of stress can limit lifespan, and protective responses to stress can extend lifespan. In this study, we identify a conserved C. elegans GATA transcription factor, egl-27, that is involved in several stress responses and aging. We found that overexpression of egl-27 extends the lifespan of wild-type animals. Furthermore, egl-27 is required for the pro-longevity effects from impaired insulin/IGF-1 like signaling (IIS), as reduced egl-27 activity fully suppresses the longevity of worms that are mutant for the IIS receptor, daf-2. egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. Consistent with its role in IIS signaling, we found that egl-27 is involved in stress response pathways. egl-27 expression is induced in the presence of multiple stresses, its targets are significantly enriched for many types of stress genes, and altering levels of egl-27 itself affects survival to heat and oxidative stress. Finally, we found that egl-27 expression increases between young and old animals, suggesting that increased levels of egl-27 in aged animals may act to promote stress resistance. These results identify egl-27 as a novel factor that links stress and aging pathways.
  • 2006 CRCnetBASE
    edited by Anthony H. Futerman and Ari Zimran.
    Chapter 1. Introduction: Overview and Historical Perspective / Roscoe O. Brady -- Chapter 2. Gaucher Disease: Molecular Biology and Genotype-Phenotype Correlations / Kathleen S. Hruska, Mary E. LaMarca, and Ellen Sidransky -- Chapter 3. Cell Biology and Biochemistry of Acid β-Glucosidase: The Gaucher Disease Enzyme / Gregory A. Grabowski, Andrzej Kazimierczuk, and Benjamin Liou -- Chapter 4. Saposin C and Other Sphingolipid Activator Proteins / Silvia Locatelli Hoops, Thomas Kolter, and Konrad Sandhoff -- Chapter 5. The X-Ray Structure of Human Acid-β-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy / Lakshmanane Premkumar, Israel Silman, Joel L. Sussman, and Anthony H. Futerman -- Chapter 6. Cellular Pathology in Gaucher Disease / Anthony H. Futerman -- Chapter 7. The Biochemistry and Cellular Biology of Sphingolipids and Glucosylceramide / James A. Shayman -- Chapter 8. The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond / Edward H. Schuchman and Silvia Muro -- Chapter 9. Gaucher Disease Animal Models / Ying Sun, You-Hai Xu, and Gregory A. Grabowski -- Chapter 10. Type 1 Gaucher Disease - Clinical Features / Pramod K. Mistry and Ari Zimran -- Chapter 11. Neuronopathic Gaucher Disease / Raphael Sc hiffmann and Ashok Vellodi -- Chapter 12. Pathologic Anatomy of Gaucher Disease: A Pictorial Essay / Robert E. Lee -- Chapter 13. Neuropathological Aspects of Gaucher Disease / Kondi Wong -- Chapter 14. Diagnosis and Laboratory Features / Carla E.M. Hollak and Johannes M.F.G. Aerts -- Chapter 15. Imaging in Gaucher Disease, Focusing on Bone Pathology / Mario Maas and Erik M. Akkerman -- Chapter 16. Radionuclide Evaluation of Gaucher Disease / Giuliano Mariani and Paola A. Erba -- Chapter 17. Epidemiology and Screening Policy / Peter J. Meikle, Maria Fuller, and John J. Hopwood Chapter 18. Enzyme Replacement Therapy for Type I Gaucher Disease / Ari Zimran, Bruno Bembi, and Gregory M. Pastores -- Chapter 19. Substrate Reduction Therapy / Frances M. Platt and Timothy M. Cox -- Chapter 20. Pharmacologic Chaperone Therapy for Lysosomal Diseases / Robert J. Desnick and Jian-Qiang Fan -- Chapter 21. The Significance of the Blood-Brain Barrier for Gaucher Disease and Other Lysosomal Storage Diseases / David J. Begley -- Chapter 22. Hematopoietic Stem Cell Transplantation, Stem Cells, and Gene Therapy / Charles Peters and William Krivit -- Chapter 23. Ethical Concerns in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avraham Steinberg -- Chapter 24. Societal Aspects in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avi Israeli -- Chapter 25. Gaucher Disease as a Model for an Orphan Disease: Medical Aspects / Jill Waalen and Ernest Beutler -- Chapter 26. Meeting the Needs of Patients with Gaucher Disease: Pioneering a Sustainable Model for Ultra-Orphan Diseases / David P. Meeker and Henri A. Termeer -- Chapter 27. Patients' Perspective / Susan Lewis, Tanya Collin-Histed, Jeremy Manuel, and Greg Macres -- Chapter 28. Societal Perspective: Comment / Abby Alpert, Alan M. Garber, and Dana P. Goldman -- Chapter 29. Gaucher Associations Around the World.
  • 2011 CRCnetBASE
    Jian Qing Shi, Taeryon Choi.
    "Gaussian Process Regression Analysis for Functional Data presents nonparametric statistical methods for functional regression analysis, specifically the methods based on a Gaussian process prior in a functional space. The authors focus on problems involving functional response variables and mixed covariates of functional and scalar variables. Covering the basics of Gaussian process regression, the first several chapters discuss functional data analysis, theoretical aspects based on the asymptotic properties of Gaussian process regression models, and new methodological developments for high dimensional data and variable selection. The remainder of the text explores advanced topics of functional regression analysis, including novel nonparametric statistical methods for curve prediction, curve clustering, functional ANOVA, and functional regression analysis of batch data, repeated curves, and non-Gaussian data. Many flexible models based on Gaussian processes provide efficient ways of model learning, interpreting model structure, and carrying out inference, particularly when dealing with large dimensional functional data. This book shows how to use these Gaussian process regression models in the analysis of functional data. Some MATLAB® and C codes are available on the first author's website"--Publisher's website.
  • 2011 Springer Protocols
    edited by Kris Gevaert, Joël Vandekerckhove.
    Mass spectrometry-driven proteomics : an introduction / Kenny Helsens [and others] -- Metabolic labeling of model organisms using heavy nitrogen (15N) / Joost W. Gouw, Bastiaan B.J. Tops, and Jeroen Krijgsveld -- Trypsin-catalyzed oxygen-18 labeling for quantitative proteomics / Wei-Jun Qian [and others] -- ICPL labeling strategies for proteome research / Friedrich Lottspeich and Josef Kellermann -- Quantitative proteome analysis using isobaric peptide termini labeling (IPTL) / Magnus Ø. Arntzen [and others] -- Complete chemical modification of amine and acid functional groups of peptides and small proteins / Casey J. Krusemark [and others] -- Production and use of stable isotope-labeled proteins for absolute quantitative proteomics / Dorothée Lebert [and others] -- Organelle proteomics / Sophie Duclos and Michel Desjardins -- Membrane protein digestion -- comparison of LPI HexaLane with traditional techniques / Ping Sui [and others] -- GeLCMS for in-depth protein characterization and advanced analysis of proteomes / Alicia Lundby and Jesper V. Olsen -- Exploring new proteome space : combining Lys-N proteolytic digestion and strong cation exchange (SCX) separation in peptide-centric MS-driven proteomics / Nadia Taouatas, Shabaz Mohammed, and Albert J.R. Heck -- Quantitation of newly synthesized proteins by pulse labeling with azidohomoalanine / Gertjan Kramer [and others] -- Analytical strategies in mass spectrometry-based phosphoproteomics / Heidi Rosenqvist, Juanying Ye, and Ole N. Jensen -- Protocol on the use of titanium dioxide chromatography for phosphoproteomics / Martijn W.H. Pinkse, Simone Lemeer, and Albert J.R. Heck -- Positional proteomics at the N-Terminus as a means of proteome simplification / Gemma R. Davidson, Stuart D. Armstrong, and Robert J. Beynon -- N-Terminomics : a high-content screen for protease substrates and their cleavage sites / John C. Timmer and Guy S. Salvesen -- Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries / Oliver Schilling, Ulrich auf dem Keller, and Christopher M. Overall -- Identification of proteolytic products and natural protein N-Termini by terminal amine isotopic labeling of substrates (TAILS) / Alain Doucet [and others] -- Lectins as tools to select for glycosylated proteins / Els J.M. Van Damme -- Strong cation exchange chromatography for analysis of sialylated glycopeptides / Katharina Lohrig, Albert Sickmann, and Urs Lewandrowski -- Titanium dioxide enrichment of sialic acid-containing glycopeptides / Giuseppe Palmisano, Sara E. Lendal, and Martin R. Larsen -- Chemical De-O-glycosylation of glycoproteins for applications in LC-based proteomics / Franz-Georg Hanisch -- Ubiquitination and degradation of proteins / Yelena Kravtsova-Ivantsiv and Aaron Ciechanover -- Bioinformatics challenges in mass spectrometry-driven proteomics / Lennart Martens -- Case study on the comparison of different software tools for automated quantification of peptides / Niklaas Colaert [and others].
  • edited by Margaret H. Preston & Margaret Ó hÓgartaigh
    "I was right glad to be rid of it" : dental medical practice in eighteenth-century Ireland / James Kelly -- Women and tuberculosis in Ireland / Greta Jones -- Infant and child mortality in Dublin a century ago / Cormac Ó Gráda -- Cure or custody : therapeutic philosophy at the Connaught District Lunatic Asylum / Oonagh Walsh -- Gender and criminal lunacy in nineteenth-century Ireland / Pauline Prior -- Between habitual drunkards and alcoholics : inebriate women and reformatories in Ireland, 1899-1919 / Elizabeth Malcolm -- Managing midwifery in Dublin : practice and practitioners, 1700-1800 / Philomena Gorey -- Lady Dudley's district nursing scheme and the Congested Districts Board, 1903-1923 / Ciara Breathnach -- "The wages of sin is death" : Lock hospitals, venereal disease, and gender in prefamine Ireland / Laurence M. Geary -- "Sickness," gender, and national health insurance in Ireland, 1920s to 1940s / Mel Cousins -- "A perpetual nightmare" : women, fertility control, the Irish state, and the 1935 ban on contraceptives / Sandra McAvoy -- "A probable source of infection" : the limitations of venereal disease policy, 1943-1951 / Susannah Riordan -- Prophylactics and prejudice : venereal diseases in Northern Ireland during the Second World War / Leanne McCormick.
  • 2009 Springer
    Friederike Kendel.
  • 2009 Springer
    Joseph D. Tucker, Dudley L. Posten, editors ; Qiang Ren ... [et al.], co-editors.
    China's concentrated HIV epidemic is on the brink of becoming a generalized one and syphilis infection has become a major public health threat. Social factors relating to gender and gender inequality exacerbate the spread of HIV and sexually transmitted infections (STI) in China. A better understanding of the proximate social determinants of HIV related to gender will be crucial to effectively curbing HIV and other STIs in China. Aspects of China's governance - including administrative procedures, the developing legal system, social institutions, and the public health infrastructure are instrumental in shaping strategies and responses to HIV. International studies suggest that women who are more economically and socially vulnerable may also have a greater risk of HIV infection, yet few initiatives have focused on discrete areas where achievable and sustainable gender policy measures could be linked to the public health response. This study presents perspectives ranging from criminology to social psychology to better understand how gender perspectives can inform HIV policy in the context of China. - Publisher's Description.
  • 2016 Springer
    Anna R. Hemnes, editor.
    Introduction -- 1.Sex Differences in Normal Pulmonary Structure and Function at Rest and during Exercise -- 2.Sex Hormone Signaling In The Lung In Health And Disease: Airways, Parenchyma And Pulmonary Vasculature -- 3.Women and COPD -- 4.Sex, gender, and asthma -- 5.Sex hormones, sex, gender and pulmonary hypertension -- 6.Pulmonary Fibrosis -- 7.Sex-Specific Differences in Lung Cancer -- 8.Lymphangioleiomyomatosis -- 9.Developmental Lung Disease. .
  • 2010 WHO
    World Health Organization.
    Also available: Print – 2010
  • 2010 WHO
    [edited by Jonathan M. Samet and Soon-Young Yoon].
    "This publication contributes to the scientific understanding of gender, women, and tobacco in the context of efforts to control the global tobacco epidemic. Topics covered include determinants of starting to use tobacco; exposure to second-hand smoke; the impact that tobacco use has on health; addiction and cessation; treatment programs; and gender and human rights policy. The publication also addresses national economic policy with regard to tobacco control, international treaties, and strategies for tobacco-free mobilization at the regional and international levels. Special attention is paid to an analysis of policies that affect girls and women throughout the life course. Men's responsibility to protect women against second-hand smoke is also highlighted"--Publisher's description.
    Also available: Print – 2010
  • 2016
    Siddhartha Mukherjee.
    The Pulitzer Prize-winning author draws on his scientific knowledge and research to describe the magisterial history of a scientific idea, the quest to decipher the master-code of instructions that makes and defines humans; that governs our form, function, and fate; and that determines the future of our children. The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 where Gregor Mendel, a monk working with pea plants, stumbles on the idea of a "unit of heredity." It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms postwar biology. It invades discourses concerning race and identity and provides startling answers to some of the most potent questions coursing through our political and cultural realms. It reorganizes our understanding of sexuality, gender identity, sexual orientation, temperament, choice, and free will, thus raising the most urgent questions affecting our personal realms. Above all, the story of the gene is driven by human ingenuity and obsessive minds--from Mendel and Darwin to Francis Crick, James Watson, and Rosalind Franklin to the thousands of scientists working today to understand the code of codes. Woven through the book is the story of Mukherjee's own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives. The moral complexity of genetics reverberates even more urgently today as we learn to "read" and "write" the human genome--unleashing the potential to change the fates and identities of our children and our children's children.--Adapted from dust jacket.
  • 2009 CRCnetBASE
    edited by Nancy Smyth Templeton.
    Also available: Print – 2009
  • 2015 Springer
    Elizabeth P. Rakoczy, editor.
    In this book, leading experts provide detailed descriptions of the exciting treatments that are expected to become part of the ophthalmologist?s arsenal within the next 10?20 years. The treatments discussed relate to a wide variety of conditions, including macular degeneration, Leber?s congenital amaurosis, retinitis pigmentosa and choroideremia. The authors explain clearly how different gene and cell therapies work and provide first-hand accounts of the difficulties that they have faced in bringing these technologies to clinical trial, such as issues relating to funding and ownership. Results achieved to date are presented, and the further steps required before the treatment in question can become a routine option are considered. Gene- and Cell-Based Treatment Strategies for the Eye is unique in showing the organic development of cutting-edge science into potential treatments for eye disease without compromising on accurate reporting of scientific facts. It will persuade the average practitioner or researcher ? whether ophthalmologist, health worker, or scientist ? that change is indeed coming and is not just a hollow promise of the tabloid media.
  • 2007. Karger
    volume editor, Jean-Nicolas Volff.
    Coevolution within and between genes / Galtier, N.; Dutheil, J. -- Evolution of protein-protein interaction network / Makino, T.; Gojobori, T. -- Bacterial flagella and type III secretion: case studies in the evolution of complexity / Pallen, M.J.; Gophna, U. -- Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems / Burroughs, A.M.; Iyer, L.M.; Aravind, L. -- General trends in the evolution of prokaryotic transcriptional regulatory networks / Madan Babu, M.; Balaji, S.; Aravind, L. -- Divergence of regulatory sequences in duplicated fish genes / Van Hellemont, R. ... [et al.] -- Evolution of gene function on the X chromosome versus the autosomes / Singh, N.D.; Petrov, D.A. -- Amino acid repeats and the structure and evolution of proteins / Albà, M.M.; Tompa, P.; Veitia, R.A. -- Origination of chimeric genes through DNA-level recombination / Arguello, J.R. ... [et al.] -- Exaptation of protein coding sequences from transposable elements / Bowen, N.J.; Jordan, I.K. -- Modulation of host genes by mammalian transposable elements / Makalowski, W.; Toda, Y. -- Modern genomes with retro-look: retrotransposed elements, retroposition and the origin of new genes / Volff, J.-N.; Brosius, J.
  • 2011 CRCnetBASE
    William Wu, Helen H. Zhang, Michael J. Welsh, and Peter B. Kaufman.
    "The third edition of this popular reference covers a variety of techniques related to gene manipulation, including DNA isolation, preparation, screening, and analysis. Topics range from very basic methods to current and sophisticated technologies, including methodologies created and tested by the authors. Other topics include approaches to grant funding and SiRNA technology. The authors offer detailed, step-by-step explanations of protocols and helpful troubleshooting guides. This edition features new techniques for every chapter, as well as several new chapters"--Provided by publisher.
  • 2014 Springer Protocols
    edited by Francesca Storici.
    RecTEPsy-mediated recombineering in Pseudomonas syringae / Bryan Swingle - Genome manipulations with bacterial recombineering and site-specific integration in Drosophila / Yi Zhang, William Schreiner, and Yikang S. Rong -- Multiple genetic manipulations of DT40 cell line / Akira Motegi and Minoru Takata -- Gene targeting of human pluripotent stem cells by homologous recombination / Sara E. Howden and James A. Thomson -- Methods for the assessment of ssODN-mediated gene correction frequencies in muscle cells / Carmen Bertoni -- Small fragment homologous replacement (SFHR) : sequence-specific modification of genomic DNA in eukaryotic cells by small DNA fragments/ Andrea Luchetti, Arianna Malgieri, and Federica Sangiuolo -- Preparation and application of triple helix forming oligonucleotides and single strand oligonucleotide donors for gene correction / Md. Rowshon Alam ... [et al.] -- Triplex-mediated genome targeting and editing / Faisal Reza and Peter M. Glazer -- Targeting piggyBac transposon integrations in the human genome / Daniel L. Galvan, Claudia S. Kettlun, and Matthew H. Wilson -- Gene targeting in human-induced pluripotent stem cells with adenoviral vectors / Kohnosuke Mitani -- Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus / Melissa A. Bartel and David V. Schaffer -- Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1 / Laetitia P.L. Pelascini and Manuel A.F.V. Gonçalves -- Designing and testing the activities of TAL effector nucleases / Yanni Lin, Thomas J. Cradick, and Gang Bao -- Bacterial one-hybrid system to isolate homing endonuclease variants with altered DNA target specificities / Rakesh Joshi and Frederick S. Gimble -- Design and analysis of site-specific single-strand nicking endonucleases for gene correction / Michael J. Metzger and Michael T. Certo -- CRISPR-Cas-mediated targeted genome editing in human cells / Luhan Yang ... [et al.] -- RNA-guided genome editing of mammalian cells / Neena K. Pyzocha ... [et al.] -- Nuclease-mediated double-strand break (DSB) enhancement of small fragment homologous recombination (SFHR) gene modification in human- induced pluripotent stem cells (hiPSCs) / R. Geoffrey Sargent, Shingo Suzuki, and Dieter C. Gruenert -- AAV-mediated gene editing via double-strand break repair / Matthew L. Hirsch and R. Jude Samulski -- Genetic modification stimulated by the induction of a site- specific break distant from the locus of correction in haploid and diploid yeast Saccharomyces cerevisiae / Samantha Stuckey and Francesca Storici -- Southern blot protocol to detect chimeric nuclease- mediated gene repair / Céline J. Rocca ... [et al.] -- High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter / Thomas J. Cradick, Christopher J. Antico, and Gang Bao -- Unbiased method for detection of genome-wide off- target effects in cell lines treated with zinc finger nucleases / Cory R. Lindsay and David B. Roth -- Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models / Eli J. Fine, Thomas J. Cradick, and Gang Bao -- Method for retinal gene repair in neonatal mouse / Marilyn Dernigoghossian ... [et al.] -- In utero delivery of oligodeoxynucleotides for gene correction / Lingzhi Cai ... [et al.] -- Portal vein delivery of viral vectors for gene therapy for hemophilia / Alexandra Sherman ... [et al.] -- Gene correction of induced pluripotent stem cells derived from a murine model of x-linked chronic granulomatous disorder / Sayandip Mukherjee and Adrian J. Thrasher -- Efficient transduction of hematopoietic stem cells and its potential for gene correction of hematopoietic diseases / Dolly Thomas and Gustavo Mostoslavsky.
  • 2015 Springer Protocols
    edited by Xuenong Bo, Joost Verhaagen.
    Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Lentiviral Vectors for Gene Delivery to the Nervous System -- Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF) -- Gene Delivery and Gene Therapy for Alzheimer's Disease -- Gene Therapy for Huntington's Disease -- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury -- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors -- Targeted Gene Therapy for Ischemic Stroke -- Adeno-Associated Viral Gene Therapy for Retinal Disorders -- Gene Therapy for Epilepsies -- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement -- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice -- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain? -- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
  • 2015 Springer Protocols
    edited by Long Jason Lu.
    Microarray Transposon Tracking for the Mapping of Conditionally Essential Genes in Campylobacter jejuni -- Identifying Essential Streptococcus sanguinis Genes Using Genome-Wide Deletion Mutation -- Defining Essential Genes and Identifying Virulence Factors of Porphyromonas gingivalis by Massively-Parallel Sequencing of Transposon Libraries (Tn-seq) -- Identification of Essential Genes and Synthetic Lethal Gene Combinations in Escherichia coli K-12 -- Identification of Genes Essential for Leptospirosis -- Identifying Essential Genes in Mycobacterium tuberculosis by Global Phenotypic Profiling -- Essential Genes in the Infection Model of Pseudomonas aeruginosa-PCR-Based Signature-Tagged Mutagenesis -- Genome-Wide Synthetic Genetic Screening by Transposon Mutagenesis in Candida albicans -- An Integrated Machine-Learning Model to Predict Prokaryotic Essential Genes -- A Statistical Framework for Improving Genomic Annotations of Transposon Mutagenesis (TM) Assigned Essential Genes -- A Proposed Essential Gene Discovery Pipeline: A Campylobacter jejuni Case Study -- Computational Prediction of Essential Metabolic Genes Using Constraint-Based Approaches -- Three Computational Tools for Predicting Bacterial Essential Genes -- Gene Essentiality Analysis Based on DEG 10, an Updated Database of Essential Genes -- Discovering Essential Domains in Essential Genes.
  • 2010 Springer
    Rodrick Wallace, Deborah Wallace.
  • 2006 Springer
    Jun Ma, editor.
  • 2012
    Dennis Jacob Bua.
    The physiological state of the genome is chromatin. Chromatin is a dynamic polymer composed of genomic DNA, histone proteins, and other factors. Dysregulation of chromatin homeostasis can lead to diverse human pathologies including cancer. This work focuses on chromatin-based mechanisms of gene regulation; more specifically the (1) targeting and (2) stabilization of gene-regulatory proteins on the chromatin template. In regard to chromatin targeting, not much is known about how gene-regulatory proteins selectively associate with their targets. Herein we detail the discovery of a new targeting factor, the nuclear phospholipid phosphatidylinositol-5-phosphate (PtdIns(5)P). PtdIns(5)P directly interacts with the tumor suppressor ING2 (inhibitor of growth family member 2) in the nucleus to coordinate gene expression of select ING2 targets. In regard to chromatin stabilization, lysine methylation is a principle mechanism for retaining chromatin-effector modules at discrete chromatin zones. Numerous lysine methylation events have been discovered on the major protein component of chromatin, histones, but relatively few specific modules have been characterized to sense these modifications. We screened through a library of putative methyl-lysine binding domains, which resulted in the identification of three novel chromatin binding modules. Taken together these data shed insight into the molecular modes of action of gene regulation by chromatin and phosphoinositide pathways.
  • 1980-
    Benjamin Lewin.
    Status: Not Checked OutLane Catalog Record
    --v. 2. Eucaryotic chromosomes.
  • 2007/2008
    ChaRandle Jordan.
    Status: Not Checked OutLane Catalog Record
  • 2011 Springer Protocols
    edited by Lorraine O'Driscoll.
    Real-time PCR and multiplex approaches / Olga L. Gurvich and Mikhail Skoblov -- Reverse-transcriptase polymerase chain reaction to detect extracellular mRNAs / Sweta Rani and Lorraine O'Driscoll -- Microarray analysis of mRNAs : experimental design and data analysis fundamentals / Jai Prakash Mehta -- Software and tools for microarray data analysis / Jai Prakash Mehta and Sweta Rani -- Analysis of gene expression as relevant to cancer cells and circulating tumour cells / Anne M. Friel, John Crown, and Lorraine O'Driscoll -- Gene expression profiling in formalin-fixed, paraffin-embedded tissues using the whole-genome DASL assay / Craig S. April and Jian-Bing Fan -- MicroRNA expression analysis : techniques suitable for studies of intercellular and extracellular MicroRNAs / Erica Hennessy and Lorraine O'Driscoll -- Western blotting analysis as a tool to study receptor tyrosine kinases / Serena Germano and Lorraine O'Driscoll -- 2D gel electrophoresis and mass spectrometry identification and analysis of proteins / Paula Meleady -- Design, construction, and analysis of cell line arrays and tissue microarrays for gene expression analysis / Kathy Gately, Keith Kerr, and Ken O'Byrne -- Immunohistochemical and immunofluorescence procedures for protein analysis / Kishore Reddy Katikireddy and Finbarr O'Sullivan -- Advanced microscopy : laser scanning confocal microscopy / Orla Hanrahan, James Harris, and Chris Egan -- Isolation of exosomes for subsequent mRNA, microRNA, and protein profiling / Sweta Rani [and others] -- Atomic force microscopy and high-content analysis : two innovative technologies for dissecting the relationship between epithelial-mesenchymal transition-related morphological and structural alterations and cell mechanical properties / Stephen T. Buckley, Anthony M. Davies, and Carsten Ehrhardt.
  • 2009 CRCnetBASE
    Hinrich Göhlmann, Willem Talloen.
    "Gene expression studies merge three disciplines with different historical backgrounds: molecular biology, bioinformatics, and biostatistics. This book tears down the omnipresent language barriers among researchers of these different backgrounds by explaining the entire process of a gene expression study from conception to interpretation. It covers important technical and statistical pitfalls and problems, helping not only to explain concepts outside the domain of researchers, but to provide additional guidance in their field of expertise. The book also describes technical and statistical methods conceptually with illustrative examples, enabling those inexperienced with gene expression studies to grasp the basic principles"--Provided by publisher.
  • ScienceDirect
    edited by David V. Goeddel.
    Also available: Print – 1990
  • 2011 ScienceDirect
    edited by Oliver Braddick, Janette Atkinson, Georgio Innocenti.
    How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioural capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioural and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action.
  • 2014 Springer Protocols
    edited by Michael F. Ochs, Department of Mathematics & Statistics, the College of New Jersey, Wing, NJ, USA.
    The Present State and Future Direction of Integrated Gene Function Analysis -- Performing Integrative Functional Genomics Analysis in GeneWeaver.org -- Functional Annotation of Differentially Regulated Gene Set Using WebGestalt: A Gene Set Predictive of Response to Ipilimumab in Tumor Biopsies -- Integrative Data-Mining Tools to Link Gene and Function -- Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large-Scale Transcriptome-Interactome Integration -- Pattern Identification in Time-Course Gene Expression Data with the CoGAPS Matrix Factorization -- Statistical Tools and R Software for Cancer Driver Probabilities -- Predicting the Functional Consequences of Somatic Missense Mutations Found in Tumors -- Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells -- Reverse Engineering Transcriptional Gene Networks -- Integrating In Silico Resources to Map a Signaling Network -- A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using Pogostick -- Construction and Application of Site-Specific Artificial Nucleases for Targeted Gene Editing -- Selection of Recombinant Antibodies from Antibody Gene Libraries -- Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Sequences from Mammalian Genes -- Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination -- In Ovo Electroporation of miRNA-Based-Plasmids to Investigate Gene Function in the Developing Neural Tube -- Proteomic Strategies: SILAC and 2D-DIGE--Powerful Tool to Investigate Cellular Alterations -- Conditional Gene-Trap Mutagenesis in Zebrafish.
  • 2007 Springer Protocols
    edited by Michael F. Ochs.
    Gene function inference from gene expression of deletion mutants / Ghislain Bidaut -- Association analysis for large-scale gene set data / Stefan A. Kirov, Bing Zhang, and Jay R. Snoddy -- Estimating gene function with least squares nonnegative matrix factorization / Guoli Wang and Michael F. Ochs -- From promoter analysis to transcriptional regulatory network prediction using PAINT / Gregory E. Gonye ... [et al.] -- Prediction of intrinsic disorder and its use in functional proteomics / Vladimir N. Uversky ... [et al.] -- Sybil : methods and software for multiple genome comparison and visualization / Jonathan Crabtree ... [et al.] -- Estimating protein function using protein-protein relationships / Shailesh V. Date -- Bioinformatics tools for modeling transcription factor target genes and epigenetic changes / Ramana V. Dvuluri -- Mining biomedical data using MetaMap Transfer (MMTx) and the Unified Medical Language System (UMLS) / John D. Osborne ... [et al.] -- Statistical methods for identifying differentially expressed gene combinations / Yen-Yi Ho ... [et al.] -- Gene function analysis using the chicken B-cell line DT40 / Randolph B. Caldwell ... [et al.] -- Design and application of a shRNA-based gene replacement retrovirus / Rugang Zhang, Peter D. Adams, and Xiaofen Ye -- Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells / Tsung-Lin Cheng and Wen-Tsan Chang -- Selection of recombinant antibodies from antibody gene libraries / Michael Hust, Stefan Dübel, and Thomas Schirrmann -- A bacterial/yeast merged two-hybrid system : protocol for yeast screening with single of parallel baits / Nadezhda Y. Tikhmyanova ... [et al.] -- A bacterial/yeast merged two-hybrid system : protocol for bacterial screening / Ilya G. Serebriiskii, Nadia Milech, and Erica A. Golemis -- Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system / Stacey Thibodeau-Beganny and J. Keith Joung.
  • 2009 Springer Protocols
    edited by Ralf Kühn, Wolfgang Wurst.
    Overview on mouse mutagenesis / Ralf Kühn and Wolfgang Wurst -- Construction of gene-targeting vectors by recombineering / Song-Choon Lee, Wei Wang, and Pentao Liu -- Gene-trap vectors and mutagenesis / Silke De-Zolt ... [et al.] -- Chromosome engineering in ES cells / Louise vander Weyden, Charles Shaw-Smith, and Allan Bradley -- Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides / Marieke Aarts ... [et al.] -- Generation of shRNA transgenic mice / Christiane Hitz ... [et al.] -- Mutagenesis of mouse embryonic stem cells with ethylmethanesulfonate / Robert Munroe and John Schimenti -- Gene targeting in mouse embryonic stem cells / Lino Tessarollo ... [et al.] -- Manipulating mouse embryonic stem cells / Eileen Southon and Lino Tessarollo -- ES cell line establishment / Heidrun Kern and Branko Zevnik -- Generation of double-knockout embryonic stem cells / Eva Wielders, Marleen Dekker, and Hein te Riele -- Differentiation analysis of pluripotent mouse embryonic stem (ES) cells in vitro / Insa S. Schroeder ... [et al.] -- Cloning of ES cells and mice by nuclear transfer / Sayaka Wakayama, Satoshi Kishigami, and Teruhiko Wakayama -- Isolation, microinjection, and transfer of mouse blastocysts / Susan W. Reid and Lino Tessarollo -- Aggregation chimeras : combining ES cells, diploid, and tetraploid embryos / Mika Tanaka ... [et al.] -- VelociMouse : fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos / Thomas M. DeChiara ... [et al.] -- Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes / Jan Rodriguez Parkitna, David Engblom, and Günther Schütz -- Inducible Cre mice / Susanne Feil, Nadejda Valtcheva, and Robert Feil -- Creation and use of a Cre recombinase transgenic database / Andras Nagy, Lynn Mar, and Graham Watts -- Transposon mutagenesis in mice / David A. Largaespada -- Lentiviral transgenesis / Alexander Pfeifer and Andreas Hofmann -- Sperm cryopreservation and in vitro fertilization / Susan Marschall, Auke Boersma, and Martin Hrabé de Angelis -- Influence of genetic background on genetically engineered mouse phenotypes / Thomas Doetschman -- Pathologic phenotyping of mutant mice / Roderick T. Bronson -- Systemic first-line phenotyping / Valérie Gailus-Durner ... [et al.]
  • 2006 Springer Protocols
    edited by Minou Bina.
    Analysis of allele-specific gene expression / Julian C. Knight -- Construction of microRNA-containing vectors for expression in mammalian cells / Yoko Fukuda, Hiroaki Kawasaki, and Kazunari Taira -- Mining microarray data at NCBI's gene expression omnibus (GEO) / Tanya Barrett and Ron Edgar -- The Stanford microarray database: a user's guide / Jeremy Gollub, Catherine A. Ball, and Gavin Sherlock -- Detecting nucleosome ladders on unique DNA sequences in mouse liver nuclei / Tomara J. Fleury, Alfred Cioffi, and Arnold Stein -- DNA methyltransferase probing of DNA-protein interactions / Scott A. Hoose and Michael P. Kladde -- Protein binding microarrays (PBMS) for rapid, high-throughput characterization of the sequence specificities of DNA binding proteins / Michael F. Berger and Martha L. Bulyk -- Quantitative profiling of protein-DNA binding on microarrays / Jiannis Ragoussis, Simon Field, and Irina A. Udalova -- Analysis of protein-DNA binding by streptavidin-agarose pulldown / Kenneth K. Wu -- Isolation and mass spectrometry of specific DNA binding proteins / Mariana Yaneva and Paul Tempst -- Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads / Patrick Rodriguez ... [et al.]. Use of genome browsers to locate your favorite genes / Minou Bina -- Methods for identifying and mapping recent segmental and gene duplications in eukaryotic genomes / Razi Khaja ... [et al.] -- Identification and mapping of paralogous genes on a known genomic DNA sequence / Minou Bina -- Quantitative DNA fiber mapping in genome research and construction of physical maps / Heinz-Ulrich G. Weier and Lisa W. Chu -- PRINS for mapping single copy genes / Avirachan T. Tharapel and Stephen S. Wachtel -- VISTA family of computational tools for comparative analysis of DNA sequences and whole genomes / Inna Dubchak and Dmitriy V. Ryaboy -- Computational prediction of cis-Regulatory modules from multispecies alignments using galaxy, table browser, and GALA / Laura Elnitski, David King, and Ross C. Hardison -- Comparative promoter analysis in vertebrate genomes with the CORG workbench / Christoph Dieterich and Martin Vingron -- cis-Regulatory region analysis using BEARR / Vinsensius Berlian Vega -- A database of 9-Mers from promoter region of human protein-coding genes / Minou Bina, Phillip Wyss, and Syed Rehan Shah -- A program toolkit for the analysis of regulatory regions of genes / Phillip Wyss, Sheryl A. Lazarus, and Minou Bina --
  • 2008 CRCnetBASE
    editors, Brett A. Lidbury and Suresh Mahalingam.
    A perspective on the future clinical impact of genetic diagnosis and gene-based drug therapies for patient health / Julian W. Tang -- Virally-encoded microRNA (miRNA): candidates for gene silencing / Ralph A. Tripp ... [et al.] -- Development of gene profile-responsive antisense agents / Sergei A. Kazakov and Brian H. Johnston -- Gene profiles in drug development: applications in target identification, biomarker discovery, and compound characterization / Eric A.G. Blomme and Dimitri Semizarov -- Gene profiles and cancer / Beverly A. Teicher -- RNA viruses and RNA-based drugs: a perfect match for RNA delivery and the identification of candidate therapeutic target inflammatory molecules / Brett A. Lidbury ... [et al.] -- Ethical considerations for a genetic future in diagnosis and drug development / Lexie Brans and Brett A. Lidbury.
  • 2013 Springer Protocols
    edited by Minou Bina.
    1. Gene regulation / Minou Bina -- 2. Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure / Guoyu Ling and David J. Waxman -- 3. DNase I digestion of isolated nuclei for genome-wide mapping of Denise hypersensitivity sites in chromatin / Guoyu Ling and David J. Waxman -- 4. Isolation and analysis of DNA derived from nucleosome-free regions / Matthew Murtha, Yatong Wang, Claudio Basilico, and Lisa Dailey -- 5. Acquisition of high quality DNA for massive parallel sequencing by in vivo chromatin immunoprecipitation / M. van den Boogaard, L.Y.E. Wong, V.M. Christoffels and P. Barnett -- 6. Luciferase assay to study the activity of a cloned promoter DNA fragment / Nina Solberg and Stefan Krauss -- 7. Promoter deletion analysis using a dual-luciferase reporter system / Yong Zhong Xu, Cynthia Kanagaratham, Sylwia Jancik and Danuta Radzioch -- 8. Application of mRNA display for in vitro selection of DNA-binding transcription factor complexes / Seiji Tateyama and Hiroshi Yanagawa -- 9. Isolation of intracellular protein -- DNA complexes using HaloCHIP an antibody-free alternative to chromatin immunoprecipitation / Danette L. Daniels and Marjeta Urh -- 10. Modified yeast one-hybrid system for genome-wide identification of transcription factor binding sites / Kazuyuki Yanai -- 11. Identifying specific protein-DNA interactions using SILAC-based quantitative proteomics / Cornelia G. Spruijt, H. Irem Baymaz, and Michiel Vermeulen -- 12. Electrophoretic mobility-shift and super-shift assays for studies and characterization of protein-DNA complexes / Elsie I. Pares-Matos -- 13. Combination of native and denaturing PAGE for the detection of protein binding regions in long fragments of genomic DNA / Kristel Kaer and Mart Speek -- 14. Quantitative nanoproteomics approach for protein complex (QNanoPX) using gold nanoparticle-based DNA probe / Shu-Hui Chen and Mei-Yin Lin -- 15. Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes / Takayuki Furumatsu and Hiroshi Asahara -- 16. Using FRET to monitor protein-induced DNA bending : the TBP-TATA complex as a model system / Rebecca H. Blair, James A. Goodrich, and Jennifer F. Kugel -- 17. Promoter independent abortive transcription assays unravel functional interactions between TFIIB and RNA polymerase / Simone C. Wiesler, Finn Werner, and Robert O.J. Weinzierl -- 18. Fluorescence cross-correlation spectroscopy (FCCS) to observe dimerization of transcription factors in living cells / Hisayo Sadamoto and Hideki Muto -- 19. Nuclear recruitment assay as a tool to validate transcription factor interactions in mammalian cells / C.J.J. Boogerd, V.M. Christoffels, and P. Barnett -- 20. Preparation of cell lines for single-cell analysis of transcriptional activation dynamics / Ilona U. Rafalska-Metcalf and Susan M. Janicki -- 21. Peptide microarrays for profiling of serine/threonine kinase activity of recombinant kinases and lysates of cells and tissue samples / Riet Hilhorst, Liesbeth Houkes, Monique Mommersteeg, Joyce Musch, Adriënne van den Berg and Rob Ruijtenbeck -- 22. Immunoaffinity purification of protein complexes from mammalian cells / Chieri Tomomori-Sato, Shigeo Sato, Ronald C. Conaway and Joan W. Conaway -- 23. Simple and efficient identification of chromatin modifying complexes and characterization of complex composition / Jeong-Heon Lee and David Skalnik -- 24. Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation / Xing-Jun Cao, Barry M. Zee, and Benjamin A. Garcia -- 25. Analysis of p300 occupancy at the early stage of stem cell differentiation by chromatin immunoprecipitation / Melanie Le May and Qiao Li -- 26. Mammalian two-hybrid assays for studies of interaction of p300 with transcription factors / Daniela B. Mendonnc̦a, Gustavo Mendonc̦a, and Lyndon F. Cooper -- 27. Fluorescence anisotropy microplate assay to investigate the interaction of full-length steroid receptor coactivator-1a with steroid receptors / Chen Zhang, Steven K. Nordeen, and David J. Shapiro -- 28. Use of histone deacetylase inhibitors to examine the roles of bromodomain and histone acetylation in p300-dependent gene expression / Jihong Chen and Qiao Li -- 29. Histone deacetylase inhibitor valproic acid as a small molecule inducer to direct the differentiation of pluripotent stem cells / Jihong Chen, Natascha Lacroix, and Qiao Li -- 30. Sedimentation and immunoprecipitation assays for analyzing complexes that repress transcription / Ping Lu, Bruce S. Hostager, Paul B. Rothman, and John D. Colgan -- 31. Methods for studies of protein interactions with different DNA methyltransferases / Jianchang Yang.
  • 2012 Springer Protocols
    edited by Bart Deplancke, Nele Gheldof.
    pt. I. Regulatory state components. 1. How do you find transcription factors? Computational approaches to compile and annotate repertoires of regulators for any genome / Juan M. Vaquerizas, Sarah A. Teichmann, and Nicholas M. Luscombe. 2. Expression pattern analysis of regulatory transcription factors in Caenorhabditis elegans / Huiyun Feng, Hannah L. Craig, and Ian A. Hope. 3. High-throughput SELEX determination of DNA sequences bound by transcription factors in vitro / Nobuo Ogawa and Mark D. Biggin. 4. Convenient determination of protein-binding DNA sequences using quadruple 9-mer-based microarray and DsRed-monomer fusion protein / Min-Jeong Kim, Pil Joong Chung, Tae-Ho Lee, Tae-Hoon Kim, Baek Hie Nahm, and Yeon-Ki Kim. 5. Analysis of specific protein-DNA interactions by bacterial one-hybrid assay / Marcus B. Noyes. 6. MITOMI : a microfluidic platform for in vitro characterization of transcription factor-DNA interaction / Sylvie Rockel, Marcel Geertz, and Sebastian J. Maerkl. 7. Detecting protein-protein interactions with the split-ubiquitin sensor / Alexander Dünkler, Judith Müller, and Nils Johnsson. 8. Genome-wide dissection of posttranscriptional and posttranslational interactions / Mukesh Bansal and Andrea Califano. 9. Linking cellular signalling to gene expression using EXT-encoded reporter libraries / Anna Botvinik and Moritz J. Rossner. 10. Sample preparation for small RNA massive parallel sequencing / Willemijn M. Gommans and Eugene Berezikov -- pt. II. Genomic components. 11. CAGE (cap analysis of gene expression) : a protocol for the detection of promoter and transcriptional networks / Hazuki Takahashi, Sachi Kato, Mitsuyoshi Murata, and Piero Carninci. 12. Detecting DNaseI-hypersensitivity sites with MLPA / Thomas Ohnesorg, Stefanie Eggers, and Stefan J. White. 13. Detecting long-range chromatin interactions using the chromosome conformation capture sequencing (4C-seq) method / Nele Gheldof, Marion Leleu, Daan Noordermeer, Jacques Rougemont, and Alexandre Reymond -- pt. III. Mapping protein-DNA interactions. 14. Analyzing transcription factor occupancy during embryo development using ChIP-seq / Yad Ghavi-Helm and Eileen E.M. Furlong. 15. Genome-wide profiling of DNA-binding proteins using barcode-based multiplex solexa sequencing / Sunil Kumar Raghav and Bart Deplancke. 16. Computational analysis of protein-DNA interactions from ChIP-seq data / Jacques Rougemont and Felix Naef. 17. Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors / Jizhou Yan and Shawn M. Burgess. 18. Using cisTargetX to predict transcriptional targets and networks in Drosophila / Delphine Potier, Zeynep Kalender Atak, Marina Naval Sanchez, Carl Herrmann, and Stein Aerts. 19. Proteomic methodologies to study transcription factor function / Harry W. Jarrett. 20. High-throughput gateway-compatible yeast one-hybrid screen to detect protein-DNA interactions / Korneel Hens, Jean-Daniel Feuz, and Bart Deplancke -- pt. IV. Visualization GRNs. 21. BioTapestry : a tool to visualize the dynamic properties of gene regulatory networks / William J.R. Longabaugh -- pt. V. Modeling of GRNs. 22. Implicit methods for qualitative modeling of gene regulatory networks / Abhishek Garg, Kartik Mohanram, Giovanni De Micheli, and Ioannis Xenarios.
  • 2012 Springer
    Nadav Ahituv, editor.
    Gene regulatory elements / Nadav Ahituv -- Hemoglobin regulatory regions / Betty S. Pace and Levi H. Makala -- Regulatory polymorphisms and osteoporosis / Huilin Jin and Stuart H. Ralston -- Gene regulation in Van Buchem disease / Gabriela G. Loots -- Cis-regulatory enhancer mutations are a cause of human limb malformations / Julia E. VanderMeer and Nadav Ahituv -- Regulatory mutations leading to cleft lip and palate / Brian C. Schutte, Walid D. Fakhouri and Daniel Zemke -- Cis-regulatory disruption at the SOX9 locus as a cause of Pierre Robin sequence / Christopher T. Gordon, Sabina Benko, Jeanne Amiel and Stanislas Lyonnet -- Regulatory mutations in human hereditary deafness / Jonathan E. Bird and Thomas B. Friedman -- Contributions of RET noncoding variation to Hirschsprung disease / Zachary E. Stine and Andrew S. McCallion -- Cis-regulatory variation and cancer / Nora F. Wasserman and Marcelo A. Nobrega -- Cohesin and human diseases / Dongbin Xu and Ian D. Krantz -- Epigenetics and human disease / Angeliki Magklara and Stavros Lomvardas.
  • 2012 Springer Protocols
    edited by Jean Peccoud.
    Part I. Assembly of oligonucleotides in synthons. Building block synthesis using the polymerase chain assembly method / Julie A. Marchand and Jean Peccoud. Oligonucleotide assembly in yeast to produce synthetic DNA fragments / Daniel G. Gibson. Topdown real-time gene synthesis / Mo Chao Huang [and others] De novo DNA synthesis using single-molecule PCR / Tuval Ben Yehezekel, Gregory Linshiz, and Ehud Shapiro -- Part II. Synthon assembly. SLIC : a method for sequence- and ligation-independent cloning / Mamie Z. Li and Stephen J. Elledge. Assembly of standardized DNA parts using bioBrick ends in E. coli / Olivia Ho-Shing [and others] Assembling DNA fragments by USER fusion / Narayana Annaluru [and others] Fusion PCR via novel overlap sequences / Kamonchai Cha-aim [and others] Using recombineering to generate point mutations : the oligonucleotide-based "Hit and Fix" method / Suhwan Chang, Stacey Stauffer, and Shyam K. Sharan. Using recombineering to generate point mutations : galK-based positive-negative selection method / Kajal Biswas, Stacey Stauffer, and Shyam K. Sharan. Assembling large DNA segments in yeast / Héloïse Muller [and others] Recursive construction of perfect DNA molecules and libraries from imperfect oligonucleotides / Gregory Linshiz, Tuval Ben Yehezkel, and Ehud Shapiro. Cloning whole bacterial genomes in yeast / Gwynedd A. Benders. Production of infectious poliovirus from synthetic viral genomes / Jeronimo Cello and Steffen Muller -- Part III. Software for gene synthesis. In silico design of functional DNA constructs / Alan Villalobos, Mark Welch, and Jeremy Minshull. Using DNAworks in designing oligonucleotides for PCR-based gene synthesis / David Hoover. De novo gene synthesis design using TmPrime software / Mo-Huang Li [and others] Design-a-gene with GeneDesign / Sarah M. Richardson [and others] -- Part IV. Education and security. Leading a successful iGEM team / Wayne Materi. The Build-a-Genome course / Eric M. Cooper [and others] DNA synthesis security / Ali Nouri and Christopher F. Chyba.
  • 2010 Springer
    Mauro Giacca.
  • 2006 ScienceDirect
    editors, Jörg Niewöhner, Christof Tannert.
    Also available: Print – 2006
  • 2016 Springer
    Shuji Terai, Takeshi Suda, editors.
    This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs, and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver. Providing not only the basic and clinical aspects of therapy, this volume is special in that it focuses on the administrative and regulatory difficulties of actual clinical application and legal regulations in different parts of the globe. By indicating the advantages and limitations of the most promising gene and cell therapies targeting the liver, this book will inspire readers to develop a feasible treatment in the next generation.
  • 2007 Springer
    edited by Kelly K. Hunt, Stephan A. Vorburger, Stephen G. Swisher.
    Adenovector-mediated cancer gene therapy / Bingliang Fang and Jack A. Roth -- Efficacy, toxicity, and immunogenicity of adenoviral vectors / Dmitry M. Shayakhmetov -- Lentiviral and retroviral vector systems / Renata Stripecke and Noriyuki Kasahara -- Vaccinia and pox-virus / Sricharan Chalikonda and David L. Bartlett -- Herpes simplex virus as a therapy for cancer / Ian J. Mohr -- Alphavirus vectors for gene therapy applications / Kenneth Lundstrom -- Vesicular stomatitis virus and RNA viruses as gene therapy vectors / Glen N. Barber -- Parvovirus vectors / Selvarangan Ponnazhagan -- Nonviral vector systems / Pui-yan Lee and Leaf Huang -- Oncogenes, tumor suppressor genes, and apoptosis-inducing genes utilized in cancer gene therapy / Lidong Zhang and Bingliang Fang -- Gene silencing therapy against cancer / Chao-Zhong Song -- Tumor targeting-retargeted adenovirus / Masato Yamamoto and David T. Curiel -- Oncolytic herpes simplex for gene therapy in preclinical and clinical trials / Richard H. Pin ... [et al.] -- Cytokine gene therapy for genitourinary cancer / Terry L. Timme ... [et al.] -- Combination of gene therapy with radiation / Anupama Munshi and Raymond E. Meyn -- Gene transfer for chemoprotection and enrichment of hematopoietic stem cells / Justin C. Roth and Stanton L. Gerson -- Nonviral genetic vaccines for cancer / Steven R. Little, Daniel G. Anderson, and Robert Langer -- Gene therapy targeted at angiogenesis and lymphangiogenesis for cancer treatment / Anita T. Tandle and Steven K. Libutti -- Tumor-specific replicating adenoviruses : delta 24 for human gliomas / Giacomo G. Vecil, Juan Fueyo, and Frederick F. Lang -- Problems, side effects, and disappointments in clinical cancer gene therapy / Ta-Chiang Liu and David H. Kirn -- Trials and tribulations in developing clinical trials of gene therapy : E1A for breast or ovarian cancer / Naoto T. Ueno ... [et al.] -- Phase I clinical experience with intravenous administration of PV701, an oncolytic virus / Andrew L. Pecora and Robert M. Lorence -- MDA-7/IL-24 as a multi-modality therapy for cancer / Sunil Chada ... [et al.] -- Development of therapeutic genes for breast cancer treatment / Mien-Chie Hung and Duen-Hwa Yan -- Steps in a translational cancer gene therapy trial / Urs W. von Holzen and Stephen G. Swisher.
    Also available: Print – 2007
  • 2015 Springer
    Ben Berkhout, Hildegund C.J. Ertl, Marc S. Weinberg, editors.
    Gene therapies for hepatitis C virus / Monique M.A. Verstegen, Qiuwei Pan, and Luc J.W. van der Laan -- Recent advances in use of gene therapy to treat hepatitis B virus infection / Kristie Bloom, Abdullah Ely, and Patrick Arbuthnot -- U1interference (U1i) for antiviral approaches / Lorea Blázquez and Puri Fortes -- Gene therapy strategies to block HIV-1 replication by RNA interference / Elena Herrera-Carrillo and Ben Berkhout -- HIV and ribozymes / Robert J. Scarborough and Anne Gatignol -- Editing CCR5: a novel approach to HIV gene therapy / Tatjana I. Cornu, Claudio Mussolino, Kristie Bloom, and Toni Cathomen -- Synthetic DNA approach to cytomegalovirus vaccine/immune therapy / Stephan J. Wu, Daniel O. Villarreal, Devon J. Shedlock, and David B. Weiner -- Vector-mediated antibody gene transfer for infectious diseases / Bruce C. Schnepp and Philip R. Johnson -- HIV latency and the non-coding RNA therapeutic landscape / Sheena Saayman, Thomas C. Roberts, Kevin V. Morris, and Marc S. Weinberg -- C peptides as entry inhibitors for gene therapy / Lisa Egerer, Hans-Peter Kiem, and Dorothee von Laer -- Aptamer-siRNA chimeras for HIV / Mayumi Takahashi, John C. Burnett, and John J. Rossi -- Index.
    Also available: Print – 2015
  • 2008 Karger
    volume editors, Ariela Benigni, Giuseppe Remuzzi.
    Renal diseases as targets of gene therapy / Phillips, B., Giannoukakis, N., Trucco, M. -- Non-viral gene delivery / Akital, H., Harashima, H -- Retrovirus vectors for gene delivery / Lech, P., Somia N.V -- Adenovirus vectors for renal targeted gene delivery / Appledorn, D.M., Seregin, S., Amalfitano, A. -- Adeno-associated virus vectors: versatile tools for in vivo gene transfer / Zentilin, L., Giacca, M. -- RNA interference in research and therapy of renal diseases / Rácz, Z., Hamar, P -- Gene therapy for acute renal failure / Torras, J., Cruzado, J.M., Grinyo, J.M -- Chronic deteriorating renal function and renal fibrosis / Isaka, Y., Takahara, S., Imai, E. -- Allograft rejection: acute and chronic studies / Tomasoni, S., Remuzzi, G., Benigni, A. -- Gene therapy for renal cancer / Haviv, Y.S., Curiel, D.T -- HIV-associated nephropathy / Wyatt, C.M., Rosenstiel, P.E., Klotman, P.E.
    Also available: Print – 2008
  • 2015 ScienceDirect
    Patrick Arbuthnot, Wits and South African Medical Research Council, Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa.
    Essentials of viruses and their suitability for treatment ssing gene therapy -- Harnessing RNAi to silence viral gene expression -- Engineering sequence-specific DNA binding proteins for antiviral gene editing -- Viral vectors for delivery of antiviral sequences -- Delivery of antiviral nucleic acids with nonviral vectors -- Gene therapy for chronic hepatitis B virus infection -- Gene therapy for hepatitis C virus infection -- Gene therapy for HIV-1 infection -- Gene therapy for respiratory viral infections -- Gene therapy for infection with hemorrhagic fever viruses -- Gene transfer for prophylaxis and therapy of viral infections -- Antiviral gene therapy : summary and perspectives.
  • 2005 Springer
    [edited by] Gérald J. Prud'homme.
    Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
    Also available: Print – 2005
  • 2013 ClinicalKey
    edited by Edmund Lattime, Stanton Gerson.
    Ex Vivo Gene Therapy: Utilization of Genetic Vectors for the Generation of Genetically Modified Cell Products for Therapy -- Targeting Tumor Vasculature Using Adeno-Associated Virus Phage Vectors Coding Tumor Necrosis Factor-a -- Viral Insertion Site Detection and Analysis in Cancer Gene Therapy -- Targeted Systemic Delivery of Therapeutic siRNA -- Bacterial Delivery of RNAi Effectors -- Gene-Directed Enzyme Prodrug Cancer Therapy -- Electroporation Gene Therapy -- Toxin-Based Cancer Gene Therapy: Under the Control of Oncofetal H19 Regulatory Sequences -- Gene Therapy in Radiotherapy of Cancer -- Advances in Oncolytic Virotherapy for Brain Tumors -- Oncolytic Adenoviruses in the Treatment of Cancer in Humans -- Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers -- Reoviral Therapy for Cancer: Strategies for Improving Antitumor Efficacy Using Radio- and Chemotherapy -- Selectively Replicating Herpes Simplex Viral Vectors -- Modified Oncolytic Herpesviruses for Gene Therapy of Cancer -- The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent -- Poxvirus-Based Strategies for Combined Vaccine and Tumor Microenvironment Manipulation -- Genetically Engineered (T Cell Receptor) T Cells for AdoptiveTherapy -- Genetically Modified Dendritic Cell Vaccines for Solid Tumors -- Dendritic Cell Vaccination -- Chemokine Gene-Modified Dendritic Cells for Cancer Therapy -- The Use of T Cell Costimulation to Enhance the Immunogenicity of Tumors -- Clinical Application of Plasmid-Based Cancer Vaccines -- Lentivector Vaccines -- Therapeutic Efficacy and Systemic Antitumor T Cell Immunity Induced by RheoSwitch-Regulated IL-12 Expression after Intratumoral Injection of Adenovirus Vector or Vector-Transduced Dendritic Cells -- Clinical Trials Using LV-P₁₄₀K-MGMT for Gliomas -- RNA Interference Therapeutics for Tumor Therapy: Promising Work in Progress -- MGMT Stem Cell Selection and Protection: Preclinical Large Animal and Clinical Studies -- Cytidine Deaminase in Myeloprotective Gene Therapy -- Genetically Engineered Salmonella typhimurium for Targeted Cancer Therapy -- Imaging of Oncolytic Virus Gene Expression -- Lentiviral-Encoded Sodium Iodide Symporter-Mediated Cancer Gene Therapy -- Bacteriophage: From Bacteria to a Successful Targeted Systemic Gene Delivery for Cancer -- Issues in Moving Gene Therapy Approaches to Early Clinical Trials -- The FDA Review Process for Cancer Gene Therapy -- Ethics in Translational Gene Transfer Research.
  • 2009 Karger
    volume editor, Allen F. Ryan.
    Gene therapy for the inner ear : challenges and promises / Ryan, A.F., Dazert, S. -- Therapeutic regulation of gene expression in the inner ear using RNA interference / Maeda, Y., Smith, R.J.H. -- Gene therapy of the inner ear using adenovirus vectors / Husseman, J., Raphael, Y. -- Repair of the vestibular system via adenovector delivery of Atoh1 : a potential treatment for balance disorders / Baker, K., Brough, D.E., Staecker, H. -- Gene therapy and stem cell transplantation : strategies for hearing restoration / Kesser, B.W., Lalwani, A.K. -- Adenoviral and AAV-mediated gene transfer to the inner ear : role of serotype, promoter, and viral load on in vivo and in vitro infection efficiencies / Luebke, A.E. ... [et al.].
    Also available: Print – 2009
  • 2015 Springer Protocols
    edited by Wolfgang Walther and Ulrike Stein.
    Aptamer targeting the ERBB2 receptor tyrosine kinase for applications in tumor therapy / Georg Mahlknecht, Michael Sela, and Yosef Yarden -- Gene gun her2/neu DNA vaccination : evaluation of vaccine efficacy in a syngeneic her2/neu mouse tumor model / Tam Nguyen-Hoai, Antonio Pezzutto, and Jörg Westermann -- MIDGE technology for the production of a fourfold gene-modified, allogenic cell-based vaccine for cancer therapy / Manuel Schmidt, Barbara Volz, Patrick Grossmann, Kerstin Heinrich, and Burghardt Wittig -- Evaluation of bystander cell killing effects in suicide gene therapy of cancer : engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis / Takeya Sato, Anton Neschadim, Ryo Nakagawa, Teruyuki Yanagisawa, and Jeffrey A. Medin -- Oncoleaking : use of the pore-forming Clostridium perfringens enterotoxin (CPE) for suicide gene therapy / Jessica Pahle, Jutta Aumann, Dennis Kobelt, and Wolfgang Walther -- iCaspase 9 suicide gene system / Xiaoou Zhou, Antonio Di Stasi, and Malcolm K. Brenner -- p53-encoding pDNA purification by affinity chromatography for cancer therapy / Ângela Sousa, João A. Queiroz, and Fani Sousa -- Phase 2, open-label, randomized study of pexa-vec (JX-594) administered by intratumoral injection in patients with unresectable primary hepatocellular carcinoma / Caroline J. Breitbach, Anne Moon, James Burke, Tae-Ho Hwang, and David H. Kirn -- Antiangiogenic metargidin peptide (AMEP) tene therapy in disseminated melanoma / Iben Spanggaard and Julie Gehl -- Clinical evaluation of ErbB-targeted CAR T-cells, rollowing intracavity delivery in patients with ErbB-expressing solid tumors / Sophie Papa, May van Schalkwyk, and John Maher.
  • 2006 ScienceDirect
    [edited by] Michael G. Kaplitt and Matthew J. During.
  • v. 1-, 2008- Springer Protocols
    edited by Joseph Ledoux.
    v. 1. Production and in vivo applications of gene transfer vectors. Preparation and quantification of pseudotyped retroviral vector / Hong Yu and Young Jik Kwon. Production of retroviral vectors for clinical use / Kenneth Cornetta, Lilith Reeves, and Scott Cross. Methods for the production of helper-dependent adenoviral vectors / Donna J. Palmer and Philip Ng. Methods for the production of first generation adenoviral vectors / Donna J. Palmer and Philip Ng. Large-scale production of recombinant adeno-associated viral vectors / Alejandro Negrete and Robert M. Kotin. Construction and production of recombinant herpes simplex virus vectors / William F. Goins ... [et al.] Plasmid-based gene transfer in mouse skeletal muscle by electroporation / Jonathan D. Schertzer and Goron S. Lynch. Chitosan nanoparticle-mediated gene transfer / Dongwon Lee and Shyam S. Mohapatra. PEG-PEI copolymers for oligonucleotide delivery to cells and tissues / Gordon J. Lutz, Shashank R. Sirsi, and Jason H. Williams. Non-viral gene delivery with cationic liposome-DNA complexes / Kai K. Ewert ... [et al.] Applications of lentiviral vectors in noninvasive molecular imaging / Abhijit De ... [et al.] Retroviral modification of mesenchymal stem cells for gene therapy of hemophilia A / Christopher B. Doering. Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells / Lucienne M. Ide, Elisabeth Javazon, and H. Trent Spencer. Assessment of CFTR function after gene transfer in vitro and in vivo / Uta Griesenbach ... [et al.] Oncolytic adenoviruses for cancer gene therapy / Ta-Chiang Liu, Stephen H. Thorne, and David H. Kirn. Design of trans-splicing adeno-associated viral vectors for Duchenne muscular dystrophy gene therapy / Yi Lai ... [et al.] Prevention of type 1 diabetes in NOD mice by genetic engineering of hematopoietic stem cells / Jessamyn Bagley, Charoui Tian, and John Iacomini. Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells / Mingjie Li and John J. Rossi. Nanoparticle-mediated gene delivery to the lung / Rajagopal Ramesh. Retroviral-mediated gene therapy for the differentiation of primary cells into a mineralizing osteoblastic phenotype / Jennifer E. Phillips and Andrés J. García. In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription / Stéphanie Decherf, Zahra Hassani, and Barbara A. Demeneix. Efficient retroviral gene transfer to epidermal stem cells / Pedro Lei and Stelios T. Andreadis.
  • 2003 ScienceDirect
    editor, Savvas C. Makrides.
    Also available: Print – 2003
  • 2012 ScienceDirect
    edited by Theodore Friedman.
    General principles of retrovirus vector design / Tammy Chang and Jiing-Kuan Yee -- Strategies for retrovirus-based correction of severe, combined immunodeficiency (SCID) / Alain Fischer, Salima Hacein-Bey-Abina, and Marina Cavazzana-Calvo -- Retrovirus and lentivirus vector design and methods of cell conditioning / Samantha Cooray, Steven J. Howe, and Adrian J. Thrasher -- Analysis of the clonal repertoire of gene-corrected cells in gene therapy / Anna Paruzynski ... [et al.] -- Developing novel lentiviral vectors into clinical products / Anna Leath and Kenneth Cornetta -- Lentivirus vectors in [beta]-thalassemia / Emmanuel Payen ... [et al.] -- Gene therapy for chronic granulomatous disease / Elizabeth M. Kang and Harry L. Malech -- Alternative splicing caused by lentiviral integration in the human genome / Arianna Moiani and Fulvio Mavilio -- Genotoxicity assay for gene therapy vectors in tumor prone mice / Eugenio Montini and Daniela Cesana -- Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy / Nathalie Cartier ... [et al.] -- Retroviral replicating vectors in cancer / Christopher R. Logg ... [et al.] -- Adeno-associated virus vectorology, manufacturing, and clinical applications / Joshua C. Grieger and R. Jude Samulski -- Gene delivery to the retina : from mouse to man / Jean Bennett, Daniel C. Chung, and Albert Maguire -- Generation of hairpin-based RNAi vectors for biological and therapeutic application / Ryan L. Boudreau and Beverly L. Davidson -- Recombinant adeno-associated viral vector reference standards / Philippe Moullier and Richard O. Snyder -- NIH oversight of human gene transfer research involving retroviral, lentiviral, and adeno-associated virus vectors and the role of the NIH Recombinant DNA Advisory Committee / Marina O'Reilly ... [et al.] -- Regulatory structures for gene therapy medicinal products in the European Union / Bettina Klug ... [et al.].
  • 2012 Springer
    Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer, editors.
  • 2010 Springer
    Jack A. Roth, editor.
  • 2015 Springer
    Panayiotis Vlamos, Athanasios Alexiou, editors.
    The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. This volume focuses on the bioinformatics and computational biology-related sessions
    Also available: Print – 2015
  • 2015 Springer
    Panayiotis Vlamos, Athanasios Alexiou, editors.
    The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address geriatrics.
    Also available: Print – 2015
  • 2015 Springer
    Panayiotis Vlamos, Athanasios Alexiou, editors.
    The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies were discussed along with their implications for various research, implementation and policy concerns. This volume focuses on neurodegenerative disease sessions.
    Also available: Print – 2015
  • 2009
    edited by J.C.E. Underwood, S.S. Cross ; illustration and chapter icons by Robert Britton.
    Status: Not Checked OutLane Catalog Record
    Introduction to pathology / J.C.E. Underwood -- Characteristics, classification, and incidence of disease / J.C.E. Underwood -- Genetic, environmental, and infectious causes of disease / J.C.E. Underwood -- Diagnostic pathology in clinical practice / S.S. Cross -- Disorders of growth, differentiation, and morphogenesis / J.P. Bury -- Response to cellular injury / J.R. Goepel -- Disorders of metabolism and homeostasis / J.C.E. Underwood -- Ischaemia, infarction, and shock / S.S. Cross -- Immunology and immunopathology / M.R. Haeney -- Inflammation / T.J. Stephenson -- Carcinogenesis and neoplasia / J.C.E. Underwood -- Ageing and death / J.C.E. Underwood -- Cardiovascular system / P.J. Gallagher, A.C. van der Wal -- Respiratory tract / W.A.H. Wallace -- Alimentary system / M.F. Dixon -- Liver, biliary system, and exocrine pancreas / J.C.E. Underwood -- Endocrine system / T.J. Stephenson -- Breast / R.A. Walker -- Female genital tract / M. Wells -- Urinary and male genital tracts / J.R. Goepel -- Kidney diseases / J.R. Shortland -- Lymph nodes, thymus, and spleen / K.A. MacLennan -- Blood and bone marrow / D.J. Culligan, H.G. Watson -- Skin / D.N. Slater -- Osteoarticular and connective tissues / D.E. Hughes -- Central and peripheral nervous systems / J.W. Ironside.
  • 2016 ClinicalKey
    John McGahan, MD, Department of Radiology, University of California Davis Health System, Sacramento, California, Sharlene A. Teefey, MD, Professor of Radiology, Abdominal Imaging Section, Washington University School of Medicine, St. Louis, Missouri, Laurence Needleman, MD, Associate Professor of Radiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia.
    Opening round -- Fair game -- Challenge -- Supplemental figures -- Index of cases -- Index of terms.
  • Middleton, William D.
    Status: Not Checked OutLane Catalog Record
  • Middleton, William D.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    edited by A. Ciancio and K.G. Mukerji.
  • 2009 ClinicalKey
    edited by Kathryn Schwarzenberger, Andrew E. Werchniak, Christine J. Ko.
    "This title in the Requisites in Dermatology series is the perfect resource for quick reference and rapid review in general dermatology. It succinctly presents all of the most essential clinical and foundational knowledge you need for certification, recertification, or practice. An extremely user-friendly full-color format, replete with full-color clinical photographs and other pertinent illustrations, makes it easy to locate and read up on any topic. Plus, full-text online access lets you consult the book from any computer, download all of the images, watch online lectures, and more."--Jacket.
  • 2007
    [edited by] Andrew I. Sokol, Eric R. Sokol.
    Status: Not Checked OutLane Catalog Record
  • 2010 CRCnetBASE
    editd by Men Jiuzhang, Guo Lei.
    Established by the Western Han dynasty more than 2,000 years ago, Traditional Chinese Medicine (TCM) is currently finding increased acceptance. Explores the thinking behind TCM, its philosophy-based theory, and its cutting-edge uses in today's clinical practice. Complete with chapter outlines and ancillary material, this carefully designed guide brings a time-tested practice back to the future.
  • 2008 Springer
    edited by M.A. Hayat.
  • AccessMedicine, latest ed. only.
    Asbury, Taylor; Cunningham, Emmett T.; Riordan-Eva, Paul; Vaughan, Daniel; Whitcher, John.
    Also available: Print – 2004-<2011>
  • 2010 Springer
    edited by M.A. Hayat.
  • v. 1, 1948.
    senior author, Franz Büchner ; co-authors, E. Letterer, H. Meessen.
    Status: Not Checked OutLane Catalog Record
  • 2012 Thieme Book
    Gabriele Steffers, Susanne Credner.
  • 2013 Springer
    K. Mohan Iyer, editor.
  • 2007 Springer
    edited by Howard L. Kaufman and Jedd D. Wolchok.
    General principles of tumor immunology -- A perspective on cancer immunology and immunotherapy -- Tumor antigens -- T cells and antigen recognition -- The role of natural killer T cells in tumor immunity -- Immunomodulatory molecules of the immune system -- HLA class I antigen abnormalities in tumors -- The local tumor microenvironment -- Tumor vaccines -- Peptide and protein vaccines for cancer -- DNA vaccines against cancer -- Recombinant viral and bacterial vaccines -- Dendritic cell vaccines -- Whole cell vaccines -- Carbohydrate vaccines against cancer -- Passive immunotherapy approaches -- Monoclonal antibody therapy of cancer -- Adoptive cellular therapy for the treatment of cancer -- Checkpoint blockade and combinatorial immunotherapies -- Clinical tumor immunotherapy -- General approaches to measuring immune responses -- Interferon therapy -- High dose interleuken-2 therapy -- Monoclonal antibodies in cancer therapy -- Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy.
  • 2014 Springer
    Brendon J. Coventry, editor.
    Written by internationally acclaimed specialists, General Surgery Risk Reduction expands on complications associated with surgery and how to reduce them, the availability of relevant information and the rapid advancements of surgical technology. Chapters provide pertinent and concise procedure descriptions creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Complications are reviewed when appropriate for the organ system and problem. The text is illustrated throughout by line drawings and photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume General Surgery Risk Reduction provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.
  • 2005 Ovid
    edited by Thomas W. Shields, Joseph LoCicero III, Ronald B. Ponn ... [et al.].
    Also available: Print – 2005
  • 2009 Ovid
    edited by Thomas W. Shields, Joseph LoCicero III, Carolyn E. Reed, Richard H. Feins.
    Anatomy of the chest thorax -- Embryology of the lungs -- Ultrastructure and morphometry of the human lung -- Cellular and molecular biology of the lung -- Surgical anatomy of the lungs -- Lymphatics of the lungs -- Pulmonary gas exchange -- Mechanics of breathing -- Radiographic evaluation of the lungs and chest -- Computed tomography of the lungs, pleura, and chest wall -- Magnetic resonance imaging of the thorax -- Positron emission tomography in chest diseases -- Radionuclide studies of the lung -- Ultrasound techniques in mediastinal, lung, and esophageal disease -- Laboratory investigations in the diagnosis of pulmonary diseases -- Diagnostic studies in lung cancer -- Bronchoscopic evaluation of the lungs and tracheobronchial tree -- Invasive diagnostic procedures -- Video-assisted thoracic surgery as a diagnostic tool -- Pulmonary physiologic assessment of operative risk -- Preoperative cardiac evaluation of the thoracic surgical patient -- Conduct of anesthesia -- The shared airway: management of the paitent with airway pathology -- Anesthesia for pediatric general thoracic surgery -- Thoracic incisions -- General features of pulmonary resections -- Thoracic surgery in the elderly -- Technical aspects of lobectomy -- Sleeve lobectomy -- Pneumonectomy and its modifications -- Tracheal sleeve pneumonectomy -- Segmentectomy and lesser pulmonary resections -- Instruments and techniques of video-assisted thoracic surgery -- Robotic-assisted surgery in thoracic diseases -- Video-assisted thoracic surgery for wedge resection, lobectomy, and pneumonectomy -- Median sternotomy and parasternal approaches to the lower trachea and mainstem bronchi -- Concomitant cardiac and pulmonary operations -- Anterior approach to superior sulcus lesions -- Complications of pulmonary resection -- Management of perioperative cardiac events -- General principles of postoperative care -- Mechanical ventilation of the surgical patient -- Chest wall deformities -- Lung hernias of the chest wall -- Infections of the chest wall -- Thoracic outlet syndrome (with transaxillary, supraclavicular, posterior, and VATS approaches) -- Thoracoscopic sympathectomy -- Anterior transthoracic approaches to the spine -- Chest wall tumors -- Chest wall reconstruction -- Embryology and anatomy of the diaphragm -- Pacing of the diaphragm -- Congenital posterolateral diaphragmatic hernias and other less common hernias of the diaphragm in infants and children -- Foramen of morgagni hernia -- Tumors of the diaphragm -- Anatomy of the pleura -- Resorption of gases from the pleural space -- Pneumothorax -- Physiology of pleural fluid production -- Benign pleural effusion -- Parapneumonic empyema -- Postsurgical empyema -- Tuberculous and fungal infections of the pleura -- Fibrothorax and decortication of the lung -- Thoracoplasty: indications and surgical considerations -- Anatomy of the thoracic duct and chylothorax -- Localized fibrous tumors of the pleura -- Diffuse malignant mesothelioma -- Technique of extrapleural pneumonectomy for diffuse malignant pleural mesothelioma -- Uncommon tumors of the pleura -- Malignant pleural effusions -- Malignant pericardial effusions -- Blunt and penetrating injuries of the chest wall, pleura, and lungs -- Barotrauma and inhalation injuries -- Acute respiratory distress syndrome -- Management of foreign bodies of the airway -- Diaphragmatic injuries -- Tracheostomy -- Surgical anatomy of the trachea and techniques of resection and reconstruction -- Management of nonneoplastic diseases of the trachea -- Benign and malignant tumors of the trachea -- Compression of the trachea by vascular rings -- Congenital lesions of the lung -- Pulmonary complications of cystic fibrosis -- Congenital vascular lesions of the lungs -- Chronic pulmonary emboli -- Bullous and bleb diseases of the lung -- Lung volume reduction -- Bacterial infections of the lungs and bronchial compressive disorders -- Pulmonary tuberculosis and other mycobacterial diseases of the lung -- Surgery for the management of mycobacterium tuberculosis and nontuberculous mycobacterial (environmental) infections of the lung -- Mycotic and actinomycetic infections of the lung -- Pleuropulmonary amebiasis -- Hydatied disease of the lung -- Pulmonary paragonimiasis and its surgical complications -- Solitary pulmonary nodule -- Diffuse lung disease -- Lung transplantation -- Evidence-based thoracic surgery -- Clinical trial design -- Lung cancer: epidemiology and carcinogenesis -- Screening for lung cancer: challenges for thoracic surgery -- Investigation and management of the nodules less than one centimeter in size -- Pathology of carcinoma of the lung -- The sentinel lymph node in non-small-cell carcinoma of the lung -- Present concepts in the molecular biology of lung cancer -- Clinical presentation of lung cancer -- Radiologic evaluation of lung cancer -- Diagnosis and staging of lung cancer -- Surgical treatment of non-small-cell lung cancer -- Lymph node dissection for lung cancer -- Unknown primary malignancy metastatic to thoracic lymph nodes -- Endoluminal management of malignant airway disease -- Basic principles of radiation therapy in locally advanced carcinoma of the lung -- Radiation therapy for carcinoma of the lung -- Adjuvant chemotherapy for non-small-cell lung cancer -- Neoadjuvant therapy for non-small-cell lung cancer -- Novel systemic therapy for advanced non-small-cell lung cancer -- Emerging technologies and techniques for the management of non-small-cell lung cancer -- Small-cell lung cancer -- Novel strategies for lung cancer immunotherapy -- Carcinoid tumors -- Adenoid cystic carcinoma and other primary salivary gland-type tumors of the lung -- Benign tumors of the lung -- Uncommon primary malignant tumors of the lung -- Secondary tumors of the lung -- Lung tumors in the immunocompromised host -- Embryology of the esophagus -- Anatomy of the esophagus -- Lymphatic drainage of the esophagus -- Physiology and physiologic studies of the esophagus -- Esophageal pH studies in esophageal disease -- Radiologic evaluation of the esophagus -- Endoscopy of the esophagus -- Modified heller myotomy -- Transthoracic resection of the esophagus -- Extended resection for esophageal carcinoma -- Transhiatal esophagectomy without thoracotomy -- Vagal-sparing esophagectomy -- Video-assisted esophageal resection -- Replacement of the esophagus with colon -- Replacement of the esophagus with jejunum -- Free intestinal transfer techniques in reconstruction of the esophagus -- Esophageal stents -- Foreign bodies in the esophagus -- Esophageal trauma -- Congenital anomalies of the esophagus -- Inflammatory diseases of the esophagus -- Esophageal motility disorders -- Chagas' disease of the esophagus -- Surgical therapy for gastroesophageal reflux disease -- Barrett's esophagus -- Esophageal endoscopic procedures in thoracic surgery -- Cardial incompetence and associated gastroesophageal reflux -- Paraesophageal hiatal hernia -- Esophageal diverticula -- Benign tumors, cysts, and duplications of the esophagus -- Carcinoma of the esophagus -- Appendix: 2009 AJCC/UICC staging of esophageal cancer -- Multimodality therapy for esophageal cancer -- Surgical palliation of inoperable carcinoma of the esophagus -- Less common malignant tumors of the esophagus -- The mediastinum, its compartments, and the mediastinal lymph nodes -- The thymus -- Mediastinal parathyroids -- Neurogenic structures of the mediastinum -- Radiographic, computed tomographic, and magnetic resonance investigation of the mediastinum -- Radionuclide studies of the mediastinum -- Mediastinal tumor markers -- Transcervical mediastinal lymph node sampling and lymphadenectomy -- Sternotomy and thoracotomy for mediastinal disease -- Video-assisted thoracic surgery for diseases within the mediastinum -- Primary pneumomediastinum -- Acute and chronic mediastinal infections -- Primary mediastinal tumors and cysts and diagnostic investigation of mediastinal masses -- Lesions masquerading as primary mediastinal tumors or cysts -- Vascular masses of the mediastinum -- Superior vena cava syndrome: clinical features, diagnosis, and treatment -- Vein grafts for the superior vena cava -- The use of prosthetic grafts to replace the superior vena cava -- Myasthenia gravis -- Pathophysiology of myasthenia gravis -- Standard thymectomy -- Transcervical thymectomy -- Video-assisted thymectomy -- Extended transsternal thymectomy -- Transcervical-transsternal maximal thymectomy for myasthenia gravis -- Evaluation of results of thymectomy for nonthymomatous myasthenia gravis -- Thymic tumors -- Benign lymph node disease involving the mediastinum -- Biological markers and pathology of mediastinal lymphomas -- Diagnosis and treatment of mediastinal lymphomas -- Benign germ cell tumors of the mediastinum -- Primary seminomas of the mediastinum -- Nonseminomatous malignant germ cell tumors of the mediastinum -- Poorly differentiated carcinoma of the mediastinum -- Benign and malignant neurogenic tumors of the mediastinum in children and adults -- Excision of hourglass tumors of the paravertebral sulcus -- Mediastinal paragangliomas and pheochromocytomas -- Mesenchymal tumors of the mediastinum -- Mediastinal parathyroid tumors -- Foregut cysts of the mediastinum in infants and children -- Foregut cysts of the mediastinum -- Gastroenteric cysts and neuroenteric cysts in infants and children -- Mesothelial and other less common cysts of the mediastinum.
  • 2014 Springer
    Hans-Jörg Oestern, Otmar Trentz, Selman Uranues, editors.
    All European countries, including those that have recently joined the European Union or are candidates for membership, currently show a clear trend towards an increasing number of accidental injuries. This holds true for a range of injuries, including accidents among the elderly, sports injuries, and trauma due to traffic accidents. The increase in the number of injuries is accompanied by rising expectations among patients, who anticipate good functional results even after serious injuries. Despite these developments, trauma surgery is not yet established as an independent field in all European countries. Against this background, there is a clear need for a book that covers the state of the art in trauma surgery. This volume, which focuses on basics in trauma surgery is intended to help to meet this need. It will also serve to harmonize the practice of trauma surgery within the European Union and to prepare for the UEMS EBSQ trauma surgery.
  • Simon N. Wood.
  • 2009 Springer
    by Michael E. Portman.
    Foreword by John H. Riskind -- Preface.-1. Nature of Generalized Anxiety Disorder.-2. Assessment and Diagnosis -- DSM-IV-TR: Diagnostic Criteria for Generalized Anxiety Disorder.-3. Conceptual Models -- Beck's Model -- Barlow's Emotion Theory -- Cognitive Avoidance Theory of Worry -- Riskind's Model of Looming Vulnerability -- The Role of Intolerance of Uncertainty -- Metacognitive Model.-4. Psychosocial Treatments for Adults with Generalized Anxiety Disorder -- Cognitive Behavioral Therapy (CBT). Metacognitive Therapy -- Supportive-Expressive Psychodynamic Therapy -- Integrative Psychotherapy -- Emotion Regulation Therapy -- Acceptance-Based Behavior Therapy.-5. Pharmacotherapy for Generalized Anxiety Disorder -- Genetics -- Neurobiology -- Medications used for Generalized Anxiety Disorder.-6. Special Populations -- Children and Adolescents -- Clinical Presentation -- Assessment and Diagnosis -- Psychosocial Treatments -- Pharmacological Treatments -- Older Adults -- Clinical Presentation -- Assessment and Diagnosis -- Psychosocial Treatments -- Pharmacological Treatments.-7. Enigmas and Paradoxes -- Prevention -- Cultural Considerations -- Treatment Resistant Generalized Anxiety Disorder.-8. Future Directions and Recommendations.-Final Remarks.Appendix A: Assessment Tools for Adults and Older Adults -- Appendix B: Assessment Tools for Children and Adolescents.
  • 2006 CRCnetBASE
    Youngjo Lee, John A. Nelder, Yudi Pawitan.
  • 2005/2006
    George L. Sen.
    Status: Not Checked OutLane Catalog Record
  • NCBI Bookshelf
    developed at the University of Washington.
  • 2014
    Jeremy A. Greene.
    Status: Not Checked OutLane Catalog Record
    Generic drugs are now familiar objects in clinics, drugstores, and households around the world. We like to think of these tablets, capsules, patches, and ointments as interchangeable with their brand-name counterparts: why pay more for the same? And yet they are not quite the same. They differ in price, in place of origin, in color, shape, and size, in the dyes, binders, fillers, and coatings used, and in a host of other ways. Claims of generic equivalence, as physician-historian Jeremy Greene reveals, are never based on being identical to the original drug in all respects, but in being the same in all ways that matter. How do we know what parts of a pill really matter? Decisions about which differences are significant and which are trivial in the world of therapeutics are not resolved by simple chemical or biological assays alone. Questions of therapeutic similarity and difference are also always questions of pharmacology and physiology, of economics and politics, of morality and belief. Greene chronicles the social, political, and cultural history of generic drugs, narrating the evolution of the generic drug industry from a set of mid-twentieth-century "schlock houses" and "counterfeiters" into an agile and surprisingly powerful set of multinational corporations in the early twenty-first century. The substitution of bioequivalent generic drugs for more expensive brand-name products is a rare success story in a field of failed attempts to deliver equivalent value in health care for a lower price. Greene's history sheds light on the controversies shadowing the success of generics: problems with the generalizability of medical knowledge, the fragile role of science in public policy, and the increasing role of industry, marketing, and consumer logics in late-twentieth-century and early twenty-first century health care.
  • 2014 CRCnetBASE
    edited by Leon Shargel, Isadore Kanfer.
    "This book collects in-depth discussions from more than 30 noted specialists on topics such as quality control, experimental formulations, pharmaceutical ingredients, conventional and modified-release products, and bioequivalence. It considers key elements in the formulation of generic drug products including the availability of raw materials and chemical purity. It contains new chapters on experimental formulation development, and the relationship between the FDA and the United States Pharmacopeia"--Provided by publisher.
  • <1988>.
    Donald O. Beers.
    Status: Not Checked OutLane Catalog Record
  • 2011 Springer
    Bohuslav Ostadal, Makoto Nagano, Naranjan S. Dhalla, editors.
    pt. 1. Genes and the heart -- pt. 2. Development and gender -- pt. 3. Mitochondrial diseases -- pt. 4. Ischemic heart disease -- pt. 5. Hypertension and arrhythmias -- pt. 6. Hypertrophy and failure.
  • 2007 Springer
    edited with commentary by Howard D. Lipshitz.
  • 2008
    Benjamin Lewin.
    Status: Not Checked OutLane Catalog Record
  • 2010 Springer
    Hoyle Leigh.
    Genes and mental illness -- How does stress work? the role of memes in epigenesis -- Culture and mental illness -- Genetic-memetic model of mental illness-migration and natural disasters as illustrations -- What do we inherit from our parents and ancestors? -- Genes -- Evolution -- Learning, imitation, and memes -- Storage and evolution of memes in the brain -- External storage of memes: culture, media, cyberspace -- Culture and the individual -- What is mental health -- What is mental illness? -- Psychiatric diagnosis: toward a memetic-epigenetic multiaxial model -- Memetic diagnosis, memetic assessment and biopsychosocial epigenetic formulation -- Principles of memetic therapy -- Broad-spectrum memetic therapy -- Specific memetic therapies -- Genetic-memetic prevention -- Overview of specific syndromes -- Attention-cognition spectrum syndromes: delirium, dementia, impulse control syndromes, ADHD, antisocial personality, obsessive-compulsive personality traits, obsessive-compulsive syndrome -- Anxiety-mood spectrum syndromes: anxiety, panic, phobias, ASD, PTSD, borderline syndrome, dependent and avoidant personalities, social phobia, bipolarity and mania, depression-neurotic and syndromic, adjustment disorders -- Reality perception spectrum syndromes (imagination, dissociation, conversion, somatoform, misattribution somatization, psychosis) -- Pleasure spectrum syndromes (substance use/abuse, additions to substances and beliefs, fanaticism) -- Primary memetic syndromes: eating disorders, factitious disorders, malingering, meme-directed destructive behaviors -- Challenges for the future.
  • 2006
    [edited by] Jonathan L. Haines, Margaret Pericak-Vance.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Christopher Jason Moore.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Paul G. Rack.
    The activation of the Hedgehog (Hh) pathway leading to Gli-dependent transcription plays critical roles in tissue patterning, homeostasis, and transformation. Despite the initial discovery of the pathway 30 years ago, a complete mechanistic understanding of Hh signal transduction remains elusive. By conducting a genome-scale overexpression screen using mammalian open reading frames (ORFs), I have identified the Rho GAP domain-containing protein Arhgap36, the homeodomain-interacting protein kinase Hipk4, and MED26, a subunit of the Mediator complex, as regulators of Gli function. This study represents the first report describing a functional role of Arhgap36 in any signaling process, and demonstrates Hipk4 modulates the cellular response to Hh ligand. The activity of MED26 was revealed in the context of the small molecule Hedgehog Pathway Inihibitor-1 (HPI-1), giving further insight to its mechanism of action. In addition, we describe the relevant mechanism of action of the small molecule JK184, a microtubule-disrupting agent that can have both positive and negative effects on pathway activity, depending on the nature of pathway perturbation. These findings provide new insights into how cells regulate Gli-dependent transcription and suggest strategies for the therapeutic intervention of Hh pathway-dependent disease.
  • 2013 Springer
    Suzanne Lentzsch, editor.
    This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
  • 2009/2010
    Ná́ní́baa' Angela Garrison.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    edited by Claude Gaultier.
    1. Respiratory control disorders: from genes to patients and back / David Gozal -- 2. Hereditary aspects of respiratory control in health and disease in humans / John V. Weil -- 3. Phox2b and the homeostatic brain / Jean-François Brunet and Christo Goridis -- 4. Congenital central hypoventilation syndrome: from patients to gene discovery / Ha Trang -- 5. Structural and functional brain abnormalities in congenital central hypoventilation syndrome / Ronald M. Harper... [et al.] -- 6. In vitro study of Pho2xb gene mutations in congenital central hypoventilation syndrome / Tiziana Bachetti and Isabella Ceccherini -- 7. Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation / Debra E. Weese-Mayer... [et al.] -- 8. The genetic basis for obstructive sleep apnea: what role for variation in respiratory control? / Susan Redline, Sanjay R. Patel -- 9. Apnea and irregular breathing in animal models: a physiogenomic approach / Motoo Yamauchi ... [et al.] -- 10. Genetic determinants of respiratory phenotypes in mice / Clarke G. Tankersley -- 11. Genes and development of respiratory rhythm generation / Jean Champagnat... [et al.] -- 12. Transcription factor control of central respiratory neuron development / Bruno C. Blanchi and Michael H. Sieweke -- 13. Lessons from mutant newborn mice with respiratory control deficits / Claude Gaultier -- 14. Tentative mouse model for the congenital central hypo-ventilation syndrome: heterozygous Phox2b mutant newborn mice / Jorge Gallego... [et al.] -- 15. Respiratory control abnormalities in necdin-null mice: implications for the pathogenesis of Prader-Willi syndrome / John J. Greer and Rachel Wevrick -- 16. Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome / John Bissonnette and Gerard Hilaire -- 17. Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders? / Gordon s Mitchell.
  • 2002 MyiLibrary
    edited by Richard A. King, Jerome I. Rotter, Arno G. Motulsky.
    Also available: Print – 2002
  • 2013 Cambridge
    [edited by] Paul Shaw, Medhi Tafti, Michael Thorpy.
    "The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine."--Provided by publisher.
  • 2013 Springer
    Gianfranco Sinagra, Luisa Mestroni, Fulvio Camerini, editors ; foreword by Perry Elliott.
  • 2006
    Andrew L. Hufton.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Gundela Meyer.
  • 2006
    Boaz Pirie Levi.
    Status: Not Checked OutLane Catalog Record
  • 2010
    edited by Bonnie S. LeRoy, Patricia McCarthy Veach, Dianne M. Bartels.
    Status: Not Checked OutLane Catalog Record
    Complicated shadows : a critique of autonomy in genetic counseling / Robert G. Resta -- Actively engaging with patients in decision making / Andrea Zanko and Michelle Fox -- Risk communication : a complex process / Shannan DeLany Dixon and Yasmine L. Konheim-Kalkstein -- Grieving : an inevitable journey / Elizabeth Gettig -- Facing patient anger / Bonnie Jeanne Baty -- Resistance and adherence : understanding the patient's perspective / Jon Weil -- Countertransference : making the unconscious conscious / Jon Weil -- Honoring diversity : cultural competence in genetic counseling / Linwood J. Lewis -- Genetic counseling strategies for working with families / Deborah L. Eunpu -- Developmentally based approaches for counseling children and adolescents / Stephanie Austin -- Genetic counseling for women with intellectual disabilities / Brenda Finucane -- Genetic counselors : caring mindfully / June A. Peters -- Professional development : reflective genetic counseling practice / Kimberly W. Zahm -- Mobilizing genetic counselor leadership skills / Nancy P. Callanan.
  • 2014 Oxford Medicine Online
    Ian M. MacFarlane, Patricia McCarthy Veach, Bonnie S. LeRoy.
    Developing research questions -- Finding sources -- Writing a review of literature -- Ethics in research -- Choosing a paradigm -- Designing a quantitative study -- Quantitative data analysis : I've got data, how do I get answers? -- Conducting qualitative genetic counseling research -- Preparing a manuscript for publication -- Guidelines for directing research.
  • 2014 Springer
    Elisabetta Baldi, Monica Muratori, editors.
    There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to aging, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. This book provides a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
    Also available: Print – 2014
  • 2008 Springer
    edited by Veikko Launis, Juha Räikkä.
    Introduction : the scope and importance of genetic democracy / Veikko Launis -- The prerequisites for genetic democracy / Helena Siipi -- Ethical expertise in democratic societies / Eerik Lagerspetz -- Towards global bioethics : the UNESCO universal declaration on bioethics and human rights / Henk ten Have -- Autonomy and genetic privacy / Juha Räikkä -- Values, rights and GMO : against radicalism -- The precautionary principle and the risks of modern agri-biotechnology / Marko Ahteensuu -- Population databanks and democracy in light of the Icelandic experience / Vilhjálmur Árnason and Stefán Hjörleifsson -- Equality and community in public deliberation : genetic democracy in Taiwan / Terence Hua Tai and Wen-Tsong Chiou -- Genetic resources, genetic democracy and genetic equity / Keekok Lee -- Moral constraints on permissible genetic design / Thomas Pogge.
  • 2010 ScienceDirect
    2010 ClinicalKey
    edited by Roy E. Weiss, Samuel Refetoff.
    Mechanisms of mutation -- Pancreas - Genetic testing in diabetes mellitus: a clinical guide to monogenic diabetes -- Obesity -- Syndromes of severe insulin resistance and/or lipodystrophy -- Pituitary -- Functioning pituitary adenomas -- Diabetes insipidus -- States of pituitary hypofunction -- Thyroid -- Congenital defects of thyroid hormone synthesis -- Developmental abnormalities of the thyroid -- Syndromes of reduced sensitivity to thyroid hormone -- Molecular genetics of thyroid cancer: pathogenetic significance and clinical applications -- Parathyroid and bone -- Genetics of hyperparathyroidism including parathyroid cancer -- Genetic diagnosis of skeletal dysplasias -- Vitamin D disorders -- Adrenal -- Congenital adrenal hyperplasia -- Genetics of adrenocortical tumors (ACT) and hypersecretory syndromes -- Hereditary pheochromocytoma and multiple endocrine neoplasia type 2 (MEN2) -- Genetic conditions associated with congenital adrenocortical insufficiency or glucocorticoid and/or mineralocorticoid resistance -- Reproductive -- Genetic considerations in the evaluation of menstrual cycle irregularities -- Genetic diagnosis of hypogonadotropic hypogonadism and Kallmann syndrome -- Disorders of sex development -- Genetic defects of androgen resistance -- Multisystem disorders -- Multiple endocrine neoplasia type 1 (MEN1) -- Genetics of polyglandular failure -- Growth -- Genetic diagnosis of growth failure -- Counseling and laboratory -- Genetic counseling -- Setting up a laboratory.
  • 2010 Springer
    Ahmad S. Teebi, editor.
  • 2010
    edited by Dhavendra Kumar ; forward by Sir David Weatherall.
    Status: Not Checked OutLane Catalog Record
    "The population of the Indian subcontinent consists of a fine amalgamation of people from diverse tribal, cultural, religious and social backgrounds. Mortality and morbidity from a vast number of medical and surgical conditions is significant and well above compared to the developed countries. Although a large component of the human health problem is related to infection, malnutrition and other preventable causes, a significant proportion is linked to hereditary factors reflecting in the form of chromosomal, single gene and complex medical diseases. Unusual and unique Mendelian disorders are not uncommon and a number of common medical conditions, such as ischemic heart disease and diabetes mellitus are relatively more prevalent among those living in the developing countries of the Indian subcontinent and as well as among the migrant population groups in the western world. However, true burden of the inherited disorders among the Asian Indians is not known, and probably underestimated. -- This text includes a detailed and concise account of the social and cultural diversity, medical demography, genetic epidemiology, consanguinity and common genetic disorders affecting people from the Indian subcontinent. In addition, specific issues of genetic services in various regions are addressed. This volume also provides a glossary for the benefit of non-genetic professionals and is aimed at a wide audience including physicians, genetic professionals, public health consultants, medical demographers, medica/social anthropologists and health administrators." -- [Publisher-supplied data]
  • 2007/2008
    Eric Dominguez Hoopfer.
    Status: Not Checked OutLane Catalog Record
  • 2008
    Nitzan Sternheim.
    Status: Not Checked OutLane Catalog Record
  • 2008/2009
    Alexander Y. Katsov.
    Status: Not Checked OutLane Catalog Record
  • 2008
    edited by Michael Rutter.
    Status: Not Checked OutLane Catalog Record
    Introduction : whither gene-environment interactions? ? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin -- Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman -- Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge -- Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson -- Longitudinal studies of gene-environment interaction in common diseases - good value for money? / Stephen P. Robertson and Richie Poulton -- Gene-environment interactions in breast cancer / Kee-Seng Chia -- Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu -- Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho -- Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez -- Conclusions : taking stock and looking ahead / Michael Rutter.
  • v. 27-28, 2006-2007. Springer
    v. 28, 2007 Springer
    Hollaender, Alexander; Setlow, Jane K.
  • 2006 Springer
    edited by Jan A. Nolta.
    Also available: Print – 2006
  • 2009 Springer Protocols
    edited by M. Dawn Teare.
    Molecular Genetics and Genetic Variation / Mohammed-Elfatih Twfieg, M. Dawn Teare -- Terminology, Concepts, and Models in Genetic Epidemiology / M. Dawn Teare, Mauro F. Koref -- An Introduction to Epidemiology / Cother Hajat -- Genetic Distance and Markers Used in Linkage Mapping / Kristina Allen-Brady, Nicola J. Camp -- Approaches to Genetic Linkage Analysis / M. Dawn Teare -- Fine-Scale Structure of the Genome and Markers Used in Association Mapping / Karen Curtin, Nicola J. Camp -- Genome-Wide Association Studies / Mark M. Iles -- Candidate Gene Association Studies / M. Dawn Teare -- Family-Based Association Studies / Frank Dudbridge -- Genome Variation: A Review of Web Resources / Andrew Collins, William J. Tapper -- Advanced Methods in Twin Studies / Jaakko Kaprio, Karri Silventoinen -- Mendelian Randomisation: A Tool for Assessing Causality in Observational Epidemiology / Nuala A. Sheehan, Sha Meng, Vanessa Didelez -- Copy Number Variation / Louise V. Wain, Martin D. Tobin -- Epigenetic Variation / Kevin Walters -- Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis / Hervé Perdry, Françoise Clerget-Darpoux -- Coronary Artery Disease: An Example Case Study / Jennifer H. Barrett -- The Genetic Epidemiology of Obesity: A Case Study / Laura M. Johnson.
  • 2011 Springer Protocols
    editor M. Dawn Teare.
    Molecular genetics and genetic variation / Mohammed-Elfatih Twfieg and M. Dawn Teare -- Terminology, concepts, and models in genetic epidemiology / M. Dawn Teare and Mauro F. Santibàñez Koref -- An introduction to epidemiology / Cother Hajat -- Genetic distance and markers used in linkage mapping / Kristina Allen-Brady and Nicola J. Camp -- Approaches to genetic linkage analysis / M. Dawn Teare -- Fine-scale structure of the genome and markers used in association mapping / Karen Curtin and Nicola J. Camp -- Genome-wide association studies / Mark M. Iles -- Candidate gene association studies / M. Dawn Teare -- Family-based association studies / Frank Dudbridge -- Genome variation : a review of web resources / Andrew Collins and William J. Tapper -- Advanced methods in twin studies / Jaakko Kaprio and Karri Silventoinen -- Mendelian randomisation : a tool for assessing causality in observational epidemiology / Nuala A. Sheehan, Sha Meng, and Vanessa Didelez -- Copy number variation / Louise V. Wain and Martin D. Tobin -- Epigenetic variation / Kevin Walters -- Modeling the effect of susceptibility factors (HLA and PTPN22) in rheumatoid arthritis / Hervé Perdry and Françoise Clerget-Darpoux -- Coronary artery disease : an example case study / Jennifer H. Barrett -- The genetic epidemiology of obesity : a case study / Laura M. Johnson.
  • 2002 Karger
    volume editors, Cor W.R.J. Cremers, Richard J.H. Smith.
    Also available: Print – 2002
  • 2016 Springer
    Janusz K. Rybakowski, Alessandro Serretti, editors.
  • 2006 ScienceDirect
    editors, Robert D. Wells, Tetsuo Ashizawa.
    Overview. Overview of the field / Tetsuo Ashizawa and Robert D. Wells -- Myotonic dystrophy. Myotonic dystrophies: an overview / Tetsuo Ashizawa and Peter S. Harper. The RNA-mediated disease process in myotonic dystrophy / Charles A. Thornton, Maurice S. Swanson, and Thomas A. Cooper. cis Effects of CTG expansion in myotonic dystrophy type 1 / Sita Reddy and Sharan Paul. Normal and pathophysiological significance of myotonic dystrophy protein kinase / Derick G. Wansink, René E.M.A. van Herpen, and Bé Wieringa. Biochemistry of myotonic dystrophy protein kinase / Ram Singh and Henry F. Epstein. Clinical and genetic features of myotonic dystrophy type 2 / Jamie M. Margolis, Laura P.W. Ranum, and John W. Day. Myotonic dystrophy type 2: clinical and genetic aspects / Ralf Krahe, Linda L. Bachinski, and Bjarne Udd. The subtelomeric D4Z4 repeat instability in facioscapulohumeral muscular dystrophy / Silvére van der Maarel, Rune R. Frants, and George W. Padberg -- Fragile X syndrome. Fragile X syndrome and fragile X-associated tremor/ataxia syndrome / Randi J. Hagerman and Paul J. Hagerman. Animal models of fragile X syndrome: mice and flies / Ben A. Oostra and David L. Nelson. Chromosomal fragile sites: mechanisms of cytogenetic expression and pathogenic consequences / Robert I. Richards -- Kennedy's disease. Clinical features and molecular biology of Kennedy's disease / CheunJu Chen and Kenneth H. Fischbeck -- Huntington's disease. Molecular pathogenesis and therapeutic targets in Huntington's disease / John S. Bett, Gillian P. Bates, and Emma Hockly. Molecular pathogenesis of Huntington's disease: the role of excitotoxicity / Mahmoud A. Pouladi ... [et al.] Huntington's disease-like 2 / Russell L. Margolis ... [et al.] -- Friedreich's ataxia. Friedreich's ataxia / Massimo Pandolfo. Experimental therapeutics for Friedreich's ataxia / Robert B. Wilson. Evolution and instability of the GAA triplet-repeat sequence in Friedreich's ataxia / Irene De Biase, Astrid Rasmussen, and Sanjay I. Bidichandani. Mouse models for Friedreich's ataxia / Hélène Puccio. Triplexes, sticky DNA, and the (GAA-TTC) trinucleotide repeat associated with Friedreich's ataxia / Leslie S. Son and Robert D. Wells -- Spinocerebellar ataxias. Phosphorylation of ataxin-1: a link between basic research and clinical application in spinocerebellar ataxia type 1 / Kerri M. Carlson and Harry T. Orr. Spinocerebellar ataxia type 2 / Stefan M. Pulst. Machado-Joseph disease/spinocerebellar ataxia type 3 / Henry Paulson. Spinocerebellar ataxia type 6 / Hidehiro Mizusawa and Kinya Ishikawa. Pathogenesis of spinocerebellar ataxia type 7: new insights from mouse models and ataxin-7 function / Dominique Helmlinger and Didier Devys. Spinocerebellar ataxia type 7: clinical features to cellular pathogenesis / Gwenn A. Garden ... [et al.] Molecular genetics of spinocerebellar ataxia type 8 / Yoshio Ikeda ... [et al.] Spinocerebellar ataxia type 10: a disease caused by an expanded (ATTCT)n pentanucleotide repeat / Tetsuo Ashizawa. DNA structures and genetic instabilities associated with spinocerebellar ataxia type 10 (ATTCT)n·(AGAAT)n repeats suggest a DNA amplification model for repeat expansion / Vladimir N. Potman ... [et al.] Spinocerebellar ataxia type 12 / Susan E. Holmes ... [et al.] Spinocerebellar ataxia 17 and Huntington's disease-like 4 / Giovanni Stevanin and Alexis Brice -- Other polyamino acid repeats. Polyalanine and polyglutamine diseases: possible common mechanisms? / Aida Abu-Baker and Guy A. Rouleau -- Biophysics of polyQ. Chemical and physical properties of polyglutamine repeat sequences / Ronald Wetzel -- In vivo instability studies. Somatic mosaicism of expanded CAG·CTG repeats in humans and mice: dynamics, mechanisms, and consequences / Peggy F. Shelbourne and Darren G. Monckton. Transgenic mouse models of unstable trinucleotide repeats: toward an understanding of disease-associated repeat size mutation / Mário Gomes-Pereira, Laurent Foiry, and Geneviève Gourdon -- Insect models. Drosophila models of polyglutamine disorders / George R. Jackson, Tzu-Kang Sang, and J. Paul Taylor -- Instability mechanisms in vivo and in vitro. Involvement of genetic recombination in microsatellite instability / Ruhee Dere, Micheal L. Hebert, and Marek Napierala. Bending the rules: unusual nucleic acid structures and disease pathology in the repeat expansion diseases / Karen Usdin. Replication of expandable DNA repeats / Sergei M. Mirkin. Error-prone repair of slipped (CTG)·(CAG) repeats and disease-associated expansions / Gagan B. Panigrahi ... [et al.] DNA repair models for understanding triplet repeat instability / Yuan Liu, Rajendra Prasad, and Samuel H. Wilson. Models of repair underlying trinucleotide DNA expansion / Irina V. Kovtun and Cynthia T. McMurray. Transcription and triplet repeat instability / Yunfu Lin, Vincent Dion, and John H. Wilson. Structural characteristics of trinucleotide repeats in transcripts / Wlodzimierz J. Krzyzosiak, Krzysztof Sobczak, and Marek Napierala -- Mutations in flanking sequences. Gross rearrangements caused by long triplet and other repeat sequences / Albino Bacolla [et al.] -- Cancer and genetic instability. Microsatellite instability in cancer / Michael J. Siciliano.
    Also available: Print – 2006
  • 2004 NCBI Bookshelf
    [Laura Dean, Johanna McEntyre].
  • 2016 Springer Protocols
    edited by Jeffrey L. Bose.
    Understanding staphylococcal nomenclature / Christina N. Krute and Jeffrey L. Bose -- Restriction-modification systems as a barrier for genetic manipulation of Staphylococcus aureus / Marat R. Sadykov -- Complementation plasmids, inducible gene-expression systems, and reporters for Staphylococci / Ralph Bertram -- De novo assembly of plasmids using yeast recombinational cloning / Ameya A. Mashruwala and Jeffrey M. Boyd -- Splicing by overlap extension PCR to obtain hybrid DNA products / Justin A. Thornton -- Method for preparation and electroporation of S. aureus and S. epidermidis / Melinda R. Grosser and Anthony R. Richardson -- Rapid isolation of DNA from staphylococcus / Kelsey L. Krausz and Jeffrey L. Bose -- Bacteriophage transduction in Staphylococcus aureus : broth-based method / Kelsey L. Krausz and Jeffrey L. Bose -- Bacteriophage transduction in Staphylococcus aureus / Michael E. Olson -- Batch transduction of transposon mutant libraries for rapid phenotype screening in staphylococcus / Katherine L. Maliszewski -- Conjugative transfer in Staphylococcus aureus / Cortney R. Halsey and Paul D. Fey -- Allelic exchange / McKenzie K. Lehman, Jeffrey L. Bose, and Kenneth W. Bayles -- Creation of staphylococcal mutant libraries using transposon Tn917 / Kelly C. Rice -- Generation of a transposon mutant library in Staphylococcus aureus and staphylococcus epidermidis using bursa aurealis / Vijaya Kumar Yajjala ... [et al.] -- Chemical and UV mutagenesis / Jeffrey L. Bose -- Pulse field gel electrophoresis / Batu K. Sharma-Kuinkel, Thomas H. Rude, and Vance G. Fowler Jr. -- RNA-sequencing of Staphylococcus aureus messenger RNA / Ronan K. Carroll, Andy Weiss, and Lindsey N. Shaw -- Quantitative real-time PCR (qPCR) workflow for analyzing Staphylococcus aureus gene expression / April M. Lewis and Kelly C. Rice -- Electrophoretic mobility shiftaAssays / Sarah E. Rowe and James P. O'Gara -- Rapid amplification of cDNA ends for RNA transcript sequencing in staphylococcus / Eric Miller.
  • 2009 ScienceDirect
    edited by Akira Sawa.
  • 2009 Springer Protocols
    edited by Christopher Baum.
    Immunomagnetic enrichment of human and mouse hematopoietic stem cells for gene therapy applications / Guillermo Guenechea, Jose C. Segovia, and Juan A. Bueren -- Isolation of human and mouse hematopoietic stem cells / Yuk Yin Ng ... [et al.] -- Murine hematopoietic stem cell transduction using retroviral vectors / Ute Modlich ... [et al.] -- Genetic modification of human hematopoietic cells: preclinical optimization of oncoretroviral-mediated gene transfer for clinical trials / Tulin Budak-Alpdogan and Isabelle Rivière -- Short-term culture of human CD34⁺ cells for lentiviral gene transfer / Francesca Santoni de Sio and Luigi Naldini -- T cell culture for gammaretroviral transfer / Sebastian Newrzela, Gunda Brandenburg, and Dorothee von Laer -- Retroviral transduction of murine primary T lymphocytes / James Lee, Michel Sadelain, and Renier Brentjens -- Lentiviral vector gene trasfer into human T cells / Els Verhoeyen, Caroline Costa, and Francois-Loic Cosset -- DNA transposons for modification of human primary T lymphocytes / Xin Huang ... [et al.] -- Retroviral gene transfer into primary human natural killer cells / Evran Alici, Tolga Sutlu, and M. Sirac Dilber -- Lentiviral vector-mediated genetic programming of mouse and human dendritic cells / Renata Stripecke -- In situ (in vivo) gene transfer into murine bone marrow stem cells / Dao Pan -- In vivo and ex vivo gene transfer in thymocytes and thymocyte precursors / Oumeya Adjali ... [et al.] -- Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells / Axel Schambach, William P. Swaney, and Johannes C.M. van der Loo -- Knock-down of gene expression in hematopoietic cells / Michaela Scherr, Letizia Venturiani, and Matthias Eder -- The use of retroviral vectors for tet-regulated gene expression in cell populations / Rainer Löw -- Detection of replication competent retrovirus and lentivirus / Lakshmi Sastry and Kenneth Cornetta -- Release testing of retroviral vectors and gene-modified cells / Diana Nordling, Anne Kaiser, and Lilith Reeves -- Copy number determination of genetically-modificed hematopoietic stem cells / Todd Schuesler ... [et al.] -- Tissue procurement for molecular studies using laser-assisted microdissection / Ulrich Lehmann and Hans Kreipe -- Leukemia diagnosis in murine bone marrow transplantation models / Zhixiong Li, Ute Modlich, and Anjali Mishra -- Humanized mouse models to study the human haematopoietic stem cell compartment / Dominique Bonnet -- Canine models of gene-modified hematopoiesis / Brian C. Beard and Hans-Peter Kiem -- Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples / Manfred Schmidt ... [et al.] -- Retroviral insertion site analysis in dominant haematopoietic clones / Olga S. Kustikova, Ute Modlich, and Boris Fehse -- Tracking gene-modified T cells in vivo / Alessandra Recchia and Fulvio Mavilio -- DNA microarray studies of hematopoietic subpopulations / Karin Pike-Overzet ... [et al.] -- Quantification of genomic mutations in murine hematopoietic cells / Hartmut Geiger ... [et al.] -- Proteomics studies after hematopoietic stem cell transplantation / Eva M. Weissinger, Petra Zürbig, and Arnold Ganser -- Spectral karyotyping and fluorescence in situ hybridization of murine cells / Cornelia Rudolph and Brigitte Schlegelberger -- Database setup for preclinical studies of gene-modified hematopoiesis / Brenden Balcik, Elke Grassman, and Lilith Reeves -- The US and EU regulatory perspectives on the clinical use of hematopoietic stem/progenitor cells genetically modified ex vivo by retroviral vectors / Carolyn A. Wilson and Klaus Cichutek.
  • 2009
    Juan Sebastian Espinosa.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Corrado Angelini.
    Section 1 Muscular Dystrophies -- Duchenne Muscular Dystrophy -- Duchenne Muscular Dystrophy carrier -- Becker Muscular Dystrophy -- Emery-Dreifuss Muscular Dystrophy type 1 -- Emery-Dreifuss Muscular Dystrophy type 2 -- Limb Girdle Muscular Dystrophy type 1B -- Limb Girdle Muscular Dystrophy type 1C -- Limb Girdle Muscular Dystrophy type 1F -- Limb Girdle Muscular Dystrophy type 2A -- Limb Girdle Muscular Dystrophy type 2B -- Limb Girdle Muscular Dystrophy type 2C -- Limb Girdle Muscular Dystrophy type 2D -- Limb Girdle Muscular Dystrophy type 2E -- Limb Girdle Muscular Dystrophy type 2F -- Limb Girdle Muscular Dystrophy type 2I -- Limb Girdle Muscular Dystrophy type 2K -- Limb Girdle Muscular Dystrophy type 2N -- Congenital Muscular Dystrophy type 1A -- Congenital Muscular Dystrophy type 1C -- Congenital Muscular Dystrophy with rigid spine -- Congenital Muscular Dystrophy with integrin-alpha-7 deficiency -- Congenital Muscular Dystrophy, Ullrich type -- Bethlem myopathy -- Facio Scapulo Humeral Muscular Dystrophy type 1A -- Facio Scapulo Humeral Muscular Dystrophy type 2 -- Section 2: Congenital Myopathies -- Congenital Multi-Mini-Core Myopathy -- Congenital Central-Core Myopathy with Malignant Hyperthermia -- Congenital Centronuclear Myopathy type 1 -- Congenital Hyaline Body Myopathy -- Congenital Myotubular Myopathy -- Congenital Nemaline Myopathy type 2 -- Congenital Fiber Type Disproportion type 1 -- Congenital Fiber Type Disproportion -- Congenital Myofibrillar Myopathy type 1 -- Congenital Myofibrillar Myopathy type 6 -- Congenital Tubular Aggregate Myopathy -- Hereditary Inclusion Body Myopathy type 2 -- Section 3: Ion Channel Disorders -- Myotonic Dystrophy type 1, Steinert Disease -- Congenital Myotonic Dystrophy -- Myotonic Dystrophy type 2, Proximal Myotonic Myopathy -- Congenital Myotonia, Thomsen Disease -- Hyperkalemic Periodic Paralysis -- Hypokalemic Periodic Paralysis type 1 -- Slow-channel Congenital Myasthenic Syndrome -- Congenital Myasthenic Syndrome -- Brody Disease -- Section 4: Metabolic Myopathies -- Glycogenosis type 2, Pompe Disease -- Glycogenosis type 3, Cori-Forbes Disease -- Glycogenosis type 5, McArdle Disease -- Danon Disease -- Kearns-Sayre Syndrome -- Chronic Progressive External Ophthalmoplegia -- MELAS (Myopathy, Encephalopathy, Lactic Acidosis, Stroke-like) -- Leigh Syndrome due to COX Deficiency -- Mitochondrial Encephalopathy with COX Deficiency -- Coenzyme Q10 Deficiency -- Multiple Symmetrical Lipomatosis -- NARP (Neuropathy, Ataxia, Retinitis Pigmentosa) -- SANDO (Sensory Ataxic Neuropathy, Dysarthria, Ophthalmoparesis) -- Systemic Primary Carnitine Deficiency -- Neutral Lipid Storage Disease with Ichthyosis -- Neutral Lipid Storage Disease with Myopathy -- Multiple Acyl-CoA Dehydrogenase Deficiency -- Carnitine-Palmitoyl-Transferase-II Deficiency -- Niemann-Pick Disease type C1 -- Section 5: Neurogenic Disorders -- Spinal Muscular Atrophy type 1, Werdnig-Hoffmann Disease -- Spinal Muscular Atrophy type 2 -- Spinal Muscular Atrophy type 3, Kugelberg-Welander Disease -- Spinal Bulbar Muscular Atrophy, Kennedy Disease -- Charcot-Marie-Tooth Disease type 1A -- Charcot-Marie-Tooth Disease type 1B -- Charcot-Marie-Tooth Disease neuronal type -- Charcot-Marie-Tooth Disease type 4A -- Charcot-Marie-Tooth Disease with pyramidal features -- Charcot-Marie-Tooth Disease type X1 -- Distal Spinal Muscular Atrophy -- Hereditary Neuropathy with Pressure Palsies -- Friedreich Ataxia -- Spastic Ataxia, Charlevoix-Saguenay type -- Ataxia-Telangiectasia, Louis-Bar Syndrome -- Spastic Paraparesis type 4 -- Spastic Paraparesis type 7 -- Optic Atrophy Plus Syndrome -- Amyotrophic Lateral Sclerosis type 1 -- Amyotrophic Lateral Sclerosis.
  • 2013
    Krystal Renee St. Julien.
    Alveolarization, the final stage of lung development, promotes gas-exchange by dividing the sac-like terminal airspaces of the lung into thin-walled pockets. Myofibroblasts are found at sites of septation, and mouse mutants in PDGFR alpha signaling lack myofibroblasts and air sacs fail to septate, suggesting that myofibroblasts play a role in septation. Further, a similar arrest in alveolarization is observed in diseases like bronchopulmonary dysplasia (BPD), a disease of premature infants that twin studies implicate may have important genetic contributions. In this thesis, I explore the developmental origins of myofibroblasts in mouse and the genetic basis of BPD. I first describe a novel protocol developed to extract DNA from dried blood spots taken from newborn infants that can be used in genotyping and genome-wide association studies (GWAS). I then describe an agnostic exploration of the genetic basis of BPD. Finally, I describe the use of genetic lineage tracing in mice to identify airway smooth muscle cells as a source of ductal myofibroblasts during lung development.
  • 2008 Springer
    Michael O'Neill, Leonardo Vanneschi, Steven Gustafson, Anna Isabel Esparcia Alcazar, Ivanoe De Falco, Antonio Della Cioppa, Ernesto Tarantino, editors.
  • 2012 Cambridge
    edited by Audrey R. Chapman.
    "The manner in which genetic research associated with addiction is conducted, interpreted and translated into clinical practice and policy initiatives raises important social, ethical and legal issues. Genetic Research on Addiction fulfils two key aims; the first is to identify the ethical issues and requirements arising when carrying out genetically-based addiction research, and the second is to explore the ethical, legal and public policy implications of interpreting, translating and applying this research. The book describes research guidelines on human protection issues such as improving the informed consent process, protecting privacy, responsibilities to minors and determining whether to accept industry funding. The broader public health policy implications of the research are explored and guidelines offered for developing effective social interventions. Highly relevant for clinicians, researchers, academics and policy-makers in the fields of addiction, mental health and public policy"--Provided by publisher.
  • 2011
    Erika L. Bustamante.
    In humans, the hormones insulin and glucagon are the principal regulators of blood sugar homeostasis. In the fruit fly, Drosophila melanogaster, the regulation of circulating sugar levels is similarly controlled by insulin-like and glucagon-like factors. Insulin signaling in Drosophila has been studied intensively; by contrast, relatively little is known about the genetic regulation of Drosophila Adipokinetic hormone (Akh), the polypeptide with glucagon-like functions, and the corpora cardiaca (CC) cells that produce Akh. Here I describe the use of an enhancer trap screen that led to the identification of a novel regulator of CC function, the homeodomain transcription factor unplugged (unpg). Knocking down unpg in the CC cells results in decreased Akh transcript levels and reduced circulating glucose and trehalose. I also describe the identification of a number of enhancer traps that are capable of driving GFP expression in the CC cells, suggesting a role for the associated genes in CC cell function. As in human diabetes, insulin deficiency in the fruit fly elevates circulating glucose levels and impairs triglyceride regulation. Reduced insulin signaling in Drosophila also increases expression of the adipokine Akh, a phenotype reminiscent of the excessive glucagon signaling that accompanies human diabetes. Thus, it remains unclear if insulin deficiency or adipokine excess is the primary basis for diabetic phenotypes in flies lacking insulin-producing cells. Here I show that simultaneous targeted ablation of cells producing Drosophila insulin and adipokinetic hormone results in hypoglycemia. Mutation of the gene encoding the Akh receptor (Akhr) reduces circulating glucose levels in adult Drosophila lacking insulin, arguing that excessive Akh signaling is the basis for hyperglycemia in insulin-deficient flies. Simultaneous attenuation of insulin and Akh synthesis also produced hypoglycemic flies. Similar approaches revealed triglyceride imbalance from insulin deficiency requires Akh. Thus adipokines like Akh, not insulin, may be the principal hormonal regulators of glucose and lipid balance in some non-mammalian animal classes and states of insulin deficiency.
  • v. 1-5, <1925>
    Terman, Lewis Madison.
    Status: Not Checked OutLane Catalog Record
    v. 1. Mental and physical traits of a thousand gifted children / L.M. Terman, assisted by B.T. Baldwin, and others -- v. 2. The early mental traits of three hundred geniuses / C.M. Cox, assisted by L.O. Gillan and others -- v. 3. The promise of youth; follow-up studies of a thousand gifted children / B.S. Burks and others -- v. 4. The gifted child grows up; twenty-five years' follow-up of a superior group / L.M. Terman and M.H. Oden -- v. 5. The gifted group at mid-life; thirty-five years' follow-up of the superior child / L.M. Terman and M.H. Oden.
  • 2003 Wellcome Trust
    edited by D.A. Christie and E.M. Tansey.
  • 2012 Springer Protocols
    edited by James M. Parry and Elizabeth M. Parry.
    The application of structure-activity relationships to the prediction of the mutagenic activity of chemicals / Philip Judson -- Bacterial mutagenicity assays : test methods / David Gatehouse -- The mouse lymphoma assay / Melvyn Lloyd and Darren Kidd -- Mammalian cell HPRT gene mutation assay : test methods / George E. Johnson -- The in vitro mammalian chromosome aberration test / Gill Claire -- The interpretation and analysis of cytogenetic data / Natalie Danford -- The in vitro micronucleus assay / Ann T. Doherty -- The in vitro and in vivo comet assays / Brian Burlinson -- Assessment of DNA interstrand crosslinks using the modified alkaline comet assay / Jian Hong Wu and Nigel J. Jones -- 32P-postlabelling for the sensitive detection of DNA adducts / Nigel J. Jones -- Methods for the detection of DNA adducts / Karen Brown -- The GADD45a-GFP GreenScreen HC assay / Richard M. Walmsley and Matthew Tate -- Real-time reverse-transcription polymerase chain reaction : technical considerations for gene expression analysis / Shareen H. Doak and Zoulikha M. Zaïr -- Cytogenetic in vivo assays in somatic cells / Ann T. Doherty, Adi Baumgartner, and Diana Anderson -- Cytogenetic methods in human biomonitoring : principles and uses / Raluca A. Mateuca, Ilse Decordier, and Micheline Kirsch-Volders -- The measurement of induced genetic change in mammalian germ cells / Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo -- Transgenic animal mutation models : a review of the models and how they function / Steve Dean -- Analysis of genotoxicity data in a regulatory context / Ian de G. Mitchell and David O.F. Skibinski.
  • 2006
    Karl H. Hecker, editor.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Kevin Morgan, Minerva M. Carrasquillo, editors.
    Since 2009, a revolution has been witnessed in Alzheimer's Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer's disease (LOAD) based on evidence of genetic association. These "AD susceptibility genes" are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses.
  • 2010 Springer
    Alexandrina L. Dumitrescu, Junya Kobayashi.
    Classification of periodontal diseases -- Evidence for the role of genetic variants in periodontitis -- A gene mutation of major effect on human disease and its association with periodontitis -- Modifying disease genes in relation to periodontitis -- Heritability of chronic periodontitis -- Heritability of aggressive periodontitis -- Heritability of gingivitis -- Heritability of peri-implantitis -- Common guidelines for association studies -- Clinical utility of genetic knowledge.
  • 2012 Springer Protocols
    edited by Jean-Rene Martin.
    In vivo functional brain imaging using a genetically encoded Ca2+-scensitive bioluminescence reporter, GFP-Aequorin / Jean-Rene Martin -- Ca2+ imaging in brain slices using bioluminescent reporters / Ludovic Tricoire, Estelle Drobac, and Bertrand Lambolez -- Calcium imaging of neural activity in the olfactory system of drosophila / Antonia Strutz [and others] -- Functional imaging of antennal lobe neurons in drosophila with synapto-pHluorin / Dinghui Yu and Ronald L. Davis -- Performing electrophysiology and two-photon calcium imaging in the adult drosophila central brain during walking behavior / M. Eugenia Chiappe and Vivek Jayaraman -- In Vivo optical recording of brain interneuron activities from a drosophila male on a treadmill / Soh Kohatsu, Masayuki Koganezawa, and Daisuke Yamamoto -- Two-photon imaging of population activity with genetically encoded calcium indicators in living flies / Robert A.A. Campbell [and others] -- Engineering and application of genetically encoded calcium indicators / Jasper Akerboom [and others] -- Imaging cAMP dynamics in the drosophila brain with the genetically encoded sensor Epac1-Camps / Katherine R. Lelito and Orie T. Shafer.
  • 2006 Wiley
    edited by Knut J. Heller.
    Part I. Application and Perspectives -- ch. 1. Transgenic modification of production traits in farm animals / Gottfried Brem, Mathias Müller -- ch. 2. Genetically modified plants / Susanne Stirn, Horst Lörz -- ch. 3. Fermentation of food by means of genetically modified yeast and filamentous fungi / Rena Leisegang, Elke Nevoigt, Anja Spielvogel, Georg Kristan, Anke Niederhaus, Ulf Stahl -- ch. 4. Production of food additives using filamentous fungi / Carsten M. Hjort -- ch. 5. Genetic engineering of bacteria used in food fermentation / Arnold Geis -- Part II. Legislation in Europe -- ch. 6. The Legal situation for genetically engineered food in Europe / Rudolf Streinz, Jan Kalbheim -- Part III. Methods of Detection -- ch. 7. Detection of genetic modifications : some basic considerations / Knut J. Heller -- ch. 8. DNA-based methods for detection of genetic modifications / Ralf Einspanier -- ch. 9. Genetic engineering of fish, and methods of detection / Hartmut Rehbein -- ch. 10. Detection methods for genetically modified crops / Rolf Meyer -- ch. 11. Methods for detection of genetically modified organisms in composite and processed foods / Karl-Heinz Engel, Francisco Moreano, Alexandra Ehlert -- ch. 12. Mutations in Lactococcus lactis and their detection / Jan Kok, Bertus van den Burg -- ch. 13. Methods for detection of genetically modified microorganisms used in food fermentation processes / Walter P. Hammes, Christian Hertel, Torsten Bauer.
  • 2012 Springer
    Jeffrey E. Green, Thomas Ried, editors.
    Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
  • 2006 CRCnetBASE
    [edited by John P. Sundberg and Tsutomu Ichiki].
  • 2012 Karger
    volume editors, Pascale Piguet, Philippe Poindron.
    Genetically modified organisms : concepts and methods -- Restriction enzymes : from their discovery to their applications -- Transforming growth factor-beta superfamily : animal models for development and disease -- Transfection of human neuroblastoma cells with Alzheimer's Disease brain hallmarks as a promising strategy to investigate the role of neurosteroidogenesis in neuroprotection -- Investigating therapeutic strategies for Fragile X syndrome in mice -- Innovative therapeutic perspectives in neuromuscular diseases -- Gene therapy for cancer treatment : state of the art -- Manipulating the mitochondrial genetic system.
  • 2009
    Daniel L. Hartl and Elizabeth W. Jones.
    Status: Not Checked OutLane Catalog Record
    Genes, genomes, and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- Chromosomes and sex-chromosome inheritance -- Genetic linkage and chromosome mapping -- Molecular biology of DNA replication and recombination -- Molecular organization of chromosomes -- Human karyotypes and chromosome behavior -- Genetics of bacteria and their viruses -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Genomics, proteomics, and transgenics -- Genetic control of development -- Molecular mechanisms of mutation and DNA repair -- Molecular genetics of the cell cycle and cancer -- Mitochondrial DNA and extranuclear inheritance -- Molecular evolution and population genetics -- The genetic basis of complex traits.
  • 2008
    Leland H. Hartwell ... [et al.].
    Status: Not Checked OutLane Catalog Record
    Genetics: the study of biological information -- Mendel's breakthrough: patterns, particles, and principles of heredity -- Extensions to mendel: complexities in relating genotype to phenotype -- The chromosome theory of inheritance -- Linkage, recombination, and the the mapping of genes on chromosomes -- DNA: how the molecule of heredity carries, replicates, and recombines information -- Anatomy and function of a gene: dissection through mutation -- Gene expression: the flow of genetic information from DNA to RNA to protein -- Deconstructing the genome: DNA at high resolution -- Reconstructing the genome through genetic and molecular analysis -- The direct detection of genotype distinguishes individual genomes -- Systems biology and proteomics -- The eukaryotic chromosome: an organelle for packaging and managing DNA -- Chromosomal rearrangements and changes in chromosome number reshape eukaryotic genomes -- The prokaryotic chromosome: genetic analysis in bacteria -- The chromosomes of organelles outside the nucleus exhibit non-mendelian patterns of inheritance -- Gene regulation in prokaryotes -- Gene regulation in eukaryotes -- Cell-cycle regulation and the genetics of cancer -- Using genetics to study development -- The genetic analysis of populations and how they evolve -- Evolution at the molecular level.
  • 2010 Springer
    Kenro Kusumi, Sally L. Dunwoodie, editors.
  • 2014
    Tom Strachan, Judith Goodship, Patrick Chinnery.
    Status: Not Checked OutLane Catalog Record
    "Genetics and Genomics in Medicine is a new textbook written for undergraduate and graduate students, as well as medical researchers, which explains the science behind the uses of genetics and genomics in medicine today. It is not just about rare inherited and chromosomal disorders, but how genetics affects the whole spectrum of human health and disease. DNA technologies are explained, with emphasis on the modern techniques that have revolutionized the use of genetic information in medicine and are indicating the role of genetics in common complex diseases. The detailed, integrative coverage of genetic approaches to treatment and prevention includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases and are given a dedicated chapter that includes new insights from cancer genome sequencing. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems"--Provided by publisher.
  • 2011
    Lewis Zuocheng Hong.
    Hundreds of coat color loci have been cloned and studied in the laboratory mouse, and most aspects of the mouse pigmentary system are conserved in other mammals. However, comparative zoologic studies suggest that some components of mammalian pigmentation are not represented as coat color mutations in laboratory mice. This dissertation aims to advance our molecular understanding of mammalian pigmentation, and strives to identify novel components of the genetic toolkit involved in generating the diverse array of coat color patterns found in nature. In the Syrian hamster, X-linked inheritance of the Sex-linked yellow (Sly) mutation results in irregular patches of black and yellow hair in heterozygous females. Female-specific variegation of black and yellow coat color is also present in the domestic cat, but curiously absent from other vertebrate species. Using a combination of comparative genomics and linkage mapping, I made key contributions towards defining a candidate interval for the Sly mutation and discovering that the hamster and cat mutations lie in non-homologous regions of the X chromosome. Periodic color patterns on animal skin, such as cheetah spots and zebra stripes, are evident across the mammalian phylogeny, but their molecular basis remains a mystery. Taking advantage of improvements in ultra high-throughput sequencing technologies, I developed a methodology called EDGE, or EcoP15I-tagged Digital Gene Expression, that is well suited for gene expression profiling in non-model organisms. Applying EDGE to black spot and yellow background regions of cheetah skin, I discovered that localized differences in Endothelin-3 expression is likely to be responsible for maintaining black spotting through a pigment-type switching mechanism in hair follicle melanocytes. The use of EDGE and other genomic approaches to generate comparative molecular profiles of mammalian skin patterns is likely to open new avenues of research into mammalian pigment patterning and initiate a molecular renaissance for a set of questions that has mostly resided in the area of theoretical biology for the past few decades.
  • 2008 Springer
    by Avery A. Sandberg, John F. Stone.
    Also available: Print – 2008
  • 2006
    Melissa Ellen Marks.
    Status: Not Checked OutLane Catalog Record
  • 2010 CRCnetBASE
    Anatoly Ruvinsky.
    Limits and uncertainty in nature and logic -- Quantum fluctuations, mutations, and "fixation" of uncertainty -- Recombination and randomness -- Uncertainty of development -- Organized randomness -- Random genetic drift and "deterministic" selection -- Life : making uncertainty certain.
  • 2016 Karger
    volume editors Michael Posthumus, Malcolm Collins.
    Core concepts in human genetics : understanding the complex phenotype of sport performance and susceptibility to sport injury / Gibson, W.T -- Nature versus nurture in determining athletic ability / Yan, X., Papadimitriou, I., Lidor, R., Eynon, N -- Recent research in the genetics of exercise training adaptation / Venezia, A.C., Roth, S.M -- Genes and athletic performance : an update / Ahmetov, I.I., Egorova, E.S., Gabdrakhmanova, L.J., Fedotovskaya, O.N -- The future of genomic research in athletic performance and adaptation to training / Wang, G., Tanaka, M., Eynon, N., North, K.N., Williams, A.G., Collins, M., Moran, C.N., Britton, S.L., Fuku, N., Ashley, E.A., Klissouras, V., Lucia, A., Ahmetov, I.I., de Geus, E., Alsayrafi, M., Pitsiladis, Y.P -- Genetics of musculoskeletal exercise-related phenotypes / Collins, M., O'Connell, K., Posthumus, M -- Genes and musculoskeletal soft-tissue injuries / Rahim, M., Collins, M., September, A -- Genetic testing for sports performance, responses to training and injury risk : practical and ethical considerations / Williams, A.G., Wackerhage, H., Day, S.H.
  • 2009 Karger
    volume editor, Malcolm Collins.
    Key concepts in human genetics : understanding the complex phenotype / W.T. Gibson -- Nature versus nurture in determining athletic ability / T.D. Brutsaert, E.J. Parra -- Genetics and sports : an overview of the pre-molecular biology era / M.W. Peeters ... [et al.] -- Genes, athlete status, and training : an overview / I.I. Ahmetov, V.A. Rogozkin -- Angiotensin : converting enzyme, renin-angiotensin system and human performance / D. Woods -- Actinin-3 and performance / N. yang, F. Garton, K. North -- East African runners : their genetics, lifestyle, and athletic prowess / V.O. Onywera -- Gene-lifestyle interactions and their consequences on human health / J. Pomeroy, A.M. Söderberg, P.W. Franks -- Genetic risk factors for musculoskeletal soft tissue injuries / M. Collins, S.M. Raleigh -- Innovative strategies for treatment of soft tissue injuries in human and animal athletes / A. Hoffmann, G. Gross -- Gene doping : possibilities and practicalities / D.J. Wells -- Genetic testing of athletes / A.G. Williams, H. Wackerhage -- The future of genetic research in exercise science and sports medicine / R.J. Trent, B. Yu.
  • 2012
    edited by Keith Wailoo, Alondra Nelson, Catherine Lee.
    Who am I? Genes and the problem of historical identity / Keith Wailoo -- Reconciliation projects : from kinship to justice / Alondra Nelson -- The unspoken significance of gender in constructing kinship, race, and nation / Catherine Lee -- A biologist's perspective on DNA and race in the genomics era / Abram Gabriel -- The dilemma of classification : the past in the present / Lundy Braun and Evelynn Hammonds -- The informationalization of race : communication, databases, and the digital coding of the genome / Peter A. Chow-White -- Forensic DNA phenotyping : continuity and change in the history of race, genetics, and policing / Pamela Sankar -- Forensic DNA and the inertial power of race in American legal practice / Jonathan Kahn -- Making history via DNA, making DNA from history : deconstructing the race-disease connection in admixture mapping / Ramya Rajagopalan and Joan H. Fujimura -- Waiting on the promise of prescribing precision : race in the era of pharmacogenomics / Sandra Soo-Jin Lee -- French families, paper facts : genetics, nation, and explanation / Nina Kohli-Laven -- Categorization, census, and multiculturalism : molecular politics and the material of nation / Amy Hinterberger -- "It's a living history, told by the real survivors of the times-DNA" : anthropological genetics in the tradition of biology as applied history / Marianne Sommer -- Cells, gene, and stories : HeLa's journey from labs to literature / Priscilla Wald -- The case of the genetic ancestor / Jennifer A. Hamilton -- Making sense of genetics, culture, and history : a case study of a native youth education program / Michelle M. Jacob -- Humanitarian DNA identification in post-apartheid South Africa / Jay D. Aronson -- Forbidden or forsaken? The (mis)use of a forbidden knowledge argument in research on race, DNA, and disease / Reanne Frank -- Genetic claims and credibility : revisiting history and remaking race / Keith Wailoo, Catherine Lee, and Alondra Nelson.
  • 2014 Karger
    volume editors, Anna L. Gloyn, Oxford, Mark I. McCarthy, Oxford.
    Genome-wide association studies in type 2 diabetes / Beer, N.L.; McCarthy, M.I. -- Fine mapping type 2 diabetes susceptibility loci / Morris, A.P. -- Whole genome and exome sequencing of type 2 diabetes / Gaulton, K.; Flannick, J.; Fuchsberger, C. -- Genome-wide association studies of glycaemic traits : a magical journey / Florez, J.C.; Barroso, I. -- Genome-wide association studies of obesity and related traits / Mohlke, K.L.; Lindgren, C.M. -- Next-generation sequencing for the diagnosis of monogenic diabetes and discovery of novel aetiologies / Ellard, S.; De Franco, E. -- Whole-exome sequencing of patients with severe disorders of insulin action / Semple, R.; Barroso, I. -- Epigenetic modifications and type 2 diabetes in humans / Ling, C. -- Insights into ?-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome / van de Bunt, M.; Morán, I.; FerrerJ.; McCarthy, M.I. -- Genomics of adipose tissue / Pinnick, K.E.; Karpe, F. -- Translating genetic association signals for diabetes and metabolic traits into molecular mechanisms for disease / Rees, M.G.; Gloyn, A.L. -- Understanding molecular mechanisms for diabetes and obesity through mouse models / Merkestein, M.; Cox, R.; Ashcroft, F. -- Genetics of drug response in diabetes / Pearson, E.R.; Florez, J.C. -- Translating advances in our understanding of the genetics of diabetes into the clinic / Gardner, D.S.; Owen, K.R.; Gloyn, A.L.
  • 2003 Karger
    volume editors, B. Wissinger, Susanne Kohl, U. Langenbeck.
    A glimpse into genomeland / Langenbeck, U. -- Epidemiology of hereditary ocular disorders / Rosenberg, T. -- Interactions of genes and environment in myopia / Feldkämper, M., Schaeffel, F. -- A molecular perspective on corneal dystrophies / Vincent, A.L., Rootman, D., Munier, F.L., Héon, E. -- Molecular genetics of cataract / Hejtmancik, J.F., Smaoui, N. -- Progress in the genetics of glaucoma / Weisschuh, N., Schiefer U. -- LHON and other optic nerve atrophies: the mitochondrial connection / Howell, N. -- Retinitis pigmentosa: genes, proteins and prospects / Hims, M.M., Diager, S.P., Inglehearn, C.F. -- Bardet-Biedl syndrome and Usher syndrome / Koenig, R. -- Genetic defects in vitamin A metabolism of the retinal pigment epithelium / Thompson, D.A., Gal, A. -- Genetics of macular dystrophies and implications for age-related macular degeneration / Klaver, C.C.W., Allikmets, R. -- Genetics of color vision deficiencies / Deeb, S.S., Kohl, S. -- Gene therapy and animal models for retinal disease / Dejneka, N.S., Rex, T.S., Bennett, J. -- Support for patients loosing [sic] sight / Trauzettel-Klosinski, S., Hahn, G.0A. - Author index -- Subject index.
    Also available: Print – 2003
  • 2012 Springer
    Karsten Suhre, editor.
  • 2007
    edited by Dirkje S. Postma, Scott T. Weiss.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Sheela Srivastava.
    Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.
  • 2013
    edited by Rajesh V. Thakker [and others].
    Status: Not Checked OutLane Catalog Record
    This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease. Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays. For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.
  • 2009 Springer
    John D. Potter, Noralane M. Lindor, editors.
  • 2016 Karger
    volume editors, Barbara Vona, Thomas Haaf.
    Genetics and deafness : a view from the inside / Blankmeyer Burke, T. Snoddon, K., Wilkinson, E. -- Hearing loss in older age and its effect on the individuals, their families, and the community / McMahon, C.M -- Audiological assessment and management in the era of precision medicine / Munro, K.J., Newton, V.E., Moore, D.R -- Next-generation newborn hearing screening / Shen, J., Morton, C.C -- Clinical challenges in diagnosing the genetic etiology of hearing loss / Birkeland, A.C., Lesperance, M.M. -- Genetic elucidation of nonsyndromic hearing loss in the high-throughput sequencing era / Vona, B., Hofrichter, M.A.H., Chioza, B.A., Crosby, A.H., Nanda, I., Haaf, T. -- Genetic modifiers of hearing loss / Yousaf, R., Friedman, T.B., Riazuddin, S. -- Genetics of age-related hearing loss / Dawes, P., Payton, A. -- Genetic modifiers of hearing loss in mice : the case of phenotypic modification in homozygous cdh23ahl age-related hearing loss / Kikkawa, Y., Miyasaka, Y. -- Using zebrafish to study human deafness and hearing regeneration / Varshney, G.K., Pei, W., Burgess, S.M. -- Current understanding and potential of gene therapy for hearing restoration in humans / Akil, O., Lustig, L.
  • 2014 ScienceDirect
    edited by Ortrud K. Steinlein.
  • 2007 Springer
    edited by Douglas T. Carrell.
    The genetics of male infertility in the era of genomics: tools for progress / Douglas T. Carrell -- The use of cDNA libraries to demonstrate a linkage between transcription and translation in male germ cells / Norman B. Hecht -- Considerations when using array technologies for male factor assessment / Adrian E Platts, David J. Dix, and Stephen A. Krawetz -- Microarray analysis of a large number of single-nucleotide polymorphisms in individual human spermatozoa / Honghua Li ... [et al.] -- Physiological and proteomic approaches to understand human sperm function: prefertilization events / Sarah J. Conner -- Genetics of idiopathic male infertility: the power of a cross-species approach / Angshumoy Roy, Yi-Nan Lin, and Martin M. Matzuk -- The immunocytogenetics of human male meiosis: a progress report / Daniel Topping, Petrice Brown, and Terry Hassold -- The clinical relevance of sperm aneuploidy / Renee H. Martin -- DNA repair genes and genomic instability in severe male factor infertility / Francesca K.E. Gordon and Dolores J. Lamb -- Germ cell-specific genes and posttranscriptional regulation in the testis / Mark S. Fox and Renee A. Reijo Pera -- The genetics of cryptorchidism / Alexander I. Agoulnik and Shu Feng -- The chromatoid body and microRNA pathways in male germ cells / Martti Parvinen ... [et al.] -- Sperm maturation in the epididymis: role of segment-specific microenvironments / Gail A. Cornwall and Hans H. von Horsten -- The structure of the Y chromosome in infertility / Leslie Ayensu-Coker, Collin Bishop, and Jan Rohozinski -- Y chromosome microdeletions and haplotypes / Ken McElreavey ... [et al.] -- The genetics of male infertility: from bench to clinic / David M. de Kretser ... [et al.] -- The future of the diagnosis of male (in)fertility / Christopher De Jonge -- Polymorphisms and male infertility / Csilla Krausz -- The genetics of abnormal protamine expression / Vincent W. Aoki and Douglas T. Carrell -- Chromatin damage and male infertility / Denny Sakkas, Davide Bizzaro, and Gian C. Manicardi -- Clinical evaluation of the genetics of male infertility / Peter N. Schlegel.
  • 2010 Karger
    volume editor, Samantha J.L. Knight.
    A parent's perspective / Gregory, J.P. -- Mental retardation : definition, classification, and etiology / Regan, R., Willatt, L. -- Technological advances in the molecular cytogenetic diagnosis of mental retardation : telomere testing and genome-wide array analysis / Kaminsky, E.B., Martin, C.L -- The importance of genome architecture in mental retardation / Mefford, H.C -- The clinical evaluation of patients with mental retardation/intellectual disability / Romano, C. -- Database aids for the evaluation of mental retardation / Firth, H.V. Carter, N.P. -- 3D shape and molecular analyses of facial dysmorphology associated with cognitive impairment / Hammond, P., Tassabehji, M. -- Monogenic causes of mental retardation / Raymond, F.L. -- Newly recognized mental retardation microdeletion/duplication syndromes -- Koolen, D.A., de Vries, B.B.A. -- Mendelian CNVs causing mental retardation and developmental disorders -- Vermeesch, J.R., de Ravel, T.J.L. -- Genetic overlaps in mental retardation, autism, and schizophrenia / Kooy, R.F. ... [et al.] -- Chromosome 22q13 rearrangements causing global developmental delay and autistic spectrum Disorder / Bonaglia, M.C. ... [et al.] -- Translating genetics research into a national health service clinical diagnostic environment / Taylor, J.
  • 2014 Springer
    Struan F.A. Grant, editor.
    In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
  • 2007
    Sophie Isabelle Candille.
    Status: Not Checked OutLane Catalog Record
  • 2008
    Kelly Ann McGowan.
    Status: Not Checked OutLane Catalog Record
  • 2009/2010
    Matthew Zack Anderson.
    Status: Not Checked OutLane Catalog Record
  • 2007
    G.I. Hickey, H.L. Fletcher, and P. Winter.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    George C. Denniston, Frederick M. Hodges, Marilyn Fayre Milos, editors.
    Tortured Bodies, Tortured Doctrines: Informed Consent as a Legal Fiction Inapplicable to Neonatal Male Circumcision -- Routine Infant Circumcision: Vital Issues that the Circumcision Proponents may be Overlooking -- The Smart Penis -- The Harm of Circumcision -- Evolution of Circumcision Methods: Not "Just a Snip" -- Penile Wounding: Complications of Routine Male Circumcision in a Typical American Family Practice -- Male Circumcision and the Potential for Unexplained Male Adolescent Suicide in Northern Ireland -- Healing the Harms of Circumcision: A Nursing Case Study -- Ten Years of Training: Family Medicine Residents as Conscientious Objectors to Circumcision -- Intersex Surgeries, Circumcision, and the Making of "Normal" -- Intersex Genital Autonomy: A Rights-Based Framework for Medical Intervention with Intersex Infants -- The SAR/ROHAN (The Possession): A Response of Somali Women to Pharaonic Circumcision/Infibulation (PhC) -- Genital Stretching Among the Venda Ethnic Group (South Africa) -- Male Circumcision Among the Venda of Limpopo (South Africa) -- Critique of African RCTs into Male Circumcision and HIV Sexual Transmission -- Randomized Controlled Trials for HIV/AIDS Prevention Among Men in Africa: Untraced Infections, Unasked Questions, and Unreported Data -- Dangerous Myths and Tragic Misconceptions: Fighting HIV and AIDS Cases in Africa with Male Circumcision Strategies -- Defying the Enlightenment: Jewish Ethnicity and Ethnic Circumcision -- Circumcision: Gender and Power -- Reclaiming Circumcision: Armenian Stories -- Self-Made Intactivism in the Middle East -- Genital Autonomy: A New Approach.
  • 1982-
    edited by David F. Paulson.
    Status: Not Checked OutLane Catalog Record
  • Zagoria, Ronald J.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    edited by Mukesh G. Harisinghani, Arumugam Rajesh.
    Covering all modalities currently used as well as emerging novel imaging tools, each chapter covers an aspect of Genitourinary Imaging with a comprehensive coverage of subspeciatlies. Genitourinary Imaging - A Case Based Approach closely mimics day to day clinical practice, and allows retention of pertinent practice information in an easy to understand format. Providing Genitourinary specific content in a portable form that can be used in close proximity to the PACS workstation, Genitourinary Imaging - A Case Based Approach is the perfect book for residents both in training and practicing as well as genitourinary radiologists worldwide.
  • Zagoria, Ronald J.
    Status: Not Checked OutLane Catalog Record
  • 2016 ClinicalKey
    Satomi Kawamoto, MD, Associate Professor of Radiology, The Russell H. Morgan Department of Radiology and Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, Katarzyna J. Macura, MD, PhD, FACR, FSCBTMR, Associate Professor of radiolgy, Urology, and Oncology, The Russell H. Morgan Department of Radiology and Radiological Science, The James Buchanan brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, The John Hopkins University School of Medicine, Baltimore, Maryland.
  • Chopra, Shailendra.
    Status: Not Checked OutLane Catalog Record
  • 2016 ClinicalKey
    Ron Zagoria, Ray Dyer, Christopher Brady.
    An introduction to radiologic methods -- The kidney and retroperitoneum : anatomy and congenital abnormalities / Raymond Dyer -- Renal masses / Ronald Zagoria -- The kidney : the diffuse parenchymal abnormality / Raymond Dyer -- The renal sinus, pelvocalyceal system, and ureter / Ronald Zagoria -- The lower urinary tract / Christopher Brady -- The female genital tract / Christopher Brady -- The male genital tract / Raymond Dyer -- Imaging of the adrenal glands / Christopher Brady -- Interventional genitourinary radiology / Ronald Zagoria.
  • 2008 Springer
    edited by Jeanette M. Potts.
    Also available: Print – 2008
  • 2015 Springer
    Cristina Magi-Galluzzi, Christopher G. Przybycin, editors.
    This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology .
  • 2015 ClinicalKey
    edited by Ming Zhou, Cristina Magi-Galluzzi.
    Nonneoplastic diseases of the prostate / Kiril Trpkov -- Neoplastic diseases of the prostate / Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the urinary bladder / Fang-Ming Deng, Jonathan Melamed -- Neoplasms of the urinary bladder / Jesse K. McKenney, Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Ming Zhou, Eyas M. Hattab, John N. Eble, Liang Cheng -- Introduction to renal biopsy / Laura Barisoni, Lois J. Arend, David B. Thomas -- Diseases of the ureter and renal pelvis / Ximing J. Yang -- Diseases of penis, urethra, and scrotum / Rajal B. Shah -- Nonneoplastic diseases of the testis / Cristina Magi-Galluzzi, Howard S. Levin -- Neoplasms of the testis / Charles C. Guo.
  • 2007 ClinicalKey
    edited by Ming Zhou, Cristina Magi-Galluzzi.
    This volume in the Foundations in Diagnostic Pathology Series packs today's most essential genitourinary pathology know-how into a compact, high-yield format! Its pragmatic, well-organized approach, abundant full-color illustrations, and at-a-glance tables make the information you need easy to access. It covers both neoplastic and non-neoplastic diseases of the genitourinary system. Reviews normal histology before examining abnormal findings. Covers all of the most commonly seen neoplastic and non-neoplastic conditions of the genitourinary system. Uses a consistent, user-friendly format to explore each entity's clinical features pathologic features (gross and microscopic) ancillary studies differential diagnoses and prognostic and therapeutic considerations. Offers hundreds of full-color illustrations that demonstrate the key features of a wide variety of pathologic lesions.
  • 2013 Springer
    Vikram S. Dogra, Gregory T. MacLennan, editors ; Ahmet Tuncay Turgut, Anastasia Canaci, associate editors ; Mehmet Ruhi Onur, assistant editor.
    1. Renal Neoplasms / Gregory T. MacLennan -- 2. Inflammatory Conditions of the Kidney / Gregory T. MacLennan -- 3. Cystic Diseases of the Kidney / Gregory T. MacLennan -- 4. Renal Calculus Disease / Can Zafer Karaman -- 5. Vascular Disorders of the Kidney / Gregory T. MacLennan -- 6. Medical Renal Disease and Transplantation Considerations / Gregory T. MacLennan -- 7. Non-neoplastic Disorders of the Renal Pelvis and Ureter / Gregory T. MacLennan -- 8. Neoplasms of the Renal Pelvis and Ureter / Gregory T. MacLennan -- 9. Renal and Ureteral Trauma / Vikram S. Dogra -- 10. Nonneoplastic Disorders of the Bladder / Gregory T. MacLennan -- 11. Neoplasms of the Bladder / Gregory T. MacLennan -- 12. Bladder Trauma / Musturay Karcaaltincaba -- 13. Congenital and Acquired Nonneoplastic Disorders of the Urethra / Gregory T. MacLennan -- 14. Neoplasms of the Urethra / Gregory T. MacLennan.
  • 2013 Springer
    Vikram S. Dogra, Gregory T. MacLennan, editors.
    Contrast Materials and Contrast Reaction Management -- Congenital and Acquired Nonneoplastic Disorders of the Prostate and Seminal Vesicles -- Neoplasms of the Prostate and Seminal Vesicles -- Congenital and Acquired Nonneoplastic Disorders of the Spermatic Cord and Testicular Adnexae -- Neoplasms of the Spermatic Cord and Testicular Adnexae -- Congenital and Acquired Nonneoplastic Disorders of the Testis -- Neoplasms of the Testis -- Congenital and Acquired Nonneoplastic Disorders of the Penis and Scrotum -- Neoplasms of the Penis and Scrotum -- Congenital and Acquired Nonneoplastic Adrenal Diseases -- Adrenal Neoplasms -- Congenital and Acquired Nonneoplastic Retroperitoneal Disorders -- Retroperitoneal Neoplasms -- Imaging of Urinary Diversion and Neobladder.
  • maintained by HGMIS for the USDOE Human Genome Program.
  • v. 1-4, 1997-99.
    volume editors, Bruce Birren ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1. Analyzing DNA -- v. 2. Detecting genes -- v. 3. Cloning systems -- v. 4. Mapping genomes.
  • 2006. Karger
    volume editor, Jean-Nicolas Volff.
    The genomic basis of disease, mechanisms and assays for genomic disorders / P. Stankiewicz, J.R. Lupski -- Gross deletions and translocations in human genetic disease / S.S. Abeysinghe, N. Chuzhanova, D.N. Cooper -- Nucleotide excision repair and related human diseases / V. Bergoglio, T. Magnaldo -- Oxidative damage to DNA in non-malignant disease / M.D. Evans, M.S. Cooke -- Dominant non-coding repeat expansions in human disease / K.A. Dick ... [et al.] -- Telomeres and telomerase in stem cells during aging and disease / Z. Ju, K.L. Rudolph -- Retrotransposable elements and human disease / P.A. Callinan, M.A. Batzer -- The spindle checkpoint and chromosomal stability / W. Qi, H. Yu -- Protein kinases that regulate chromosome stability and their downstream targets / H. Nojima -- The role of the APC tumor suppressor in chromosomal instability / P. Alberici, R. Fodde -- c-Myc, genomic instability, and disease -- F. Kuttler, S. Mai -- Nijmegen breakage syndrome and functions of the responsible protein, NBS1 / A. Antoccia ... [et al.] -- Werner syndrome, aging, and cancer / A. Ozgenc, L.A. Loeb -- Fanconi anemia / R. Kalb ... [et al.].
  • v. 1-, 2007- Springer
  • 2016 Springer
    Toni Cathomen, Matthew Hirsch, Matthew Porteus, editors.
    Gene editing 20 years later -- The development and use of zinc-finger nucleases -- The use and development of TAL effector nucleases -- Genome editing for neuromuscular diseases -- Phage integrases for genome editing -- Precise genome modification using triplex forming oligonucleotides and peptide nucleic acids -- Genome editing by Aptamer-Guided Gene Targeting (AGT) -- Stimulation of AAV gene editing via DSB repair -- Engineered nucleases and trinucleotide repeat diseases -- Using engineered nucleases to create HIV-resistant cells -- Strategies to determine off-target effects of engineered nucleases -- Cellular engineering and disease modeling with gene-editing nucleases -- Index.
    Also available: Print – 2016
  • 2005 Springer
    edited by Erich A. Nigg.
    Also available: Print – 2005
  • 2007 Springer
    volume editor, Dirk-Henner Lankenau.
    From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. It begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. It also reviews the cellular responses to radiation and genotoxic stress affecting whole genomes.
  • 2011
    Penka Vassileva Markova-Raina.
    Recent advances in technology have unleashed a breathtaking amount of genome sequence data. My doctoral research builds on the resulting opportunities of whole genome sequence data and analysis in a quest for gaining new insights into molecular evolution, and in particular molecular evolution and adaptation of proteins. Chapter One of my dissertation is focused on methodology, specifically the impact that the choice of multiple sequence alignment procedure has on the inference of positive selection. I find that selection inference is highly dependent on the choice of alignment procedure. Furthermore, in the case of the 12 Drosophila genomes proteins and commonly used alignment programs, most of the inferences are false positives, caused by misaligned codons. These results put into question the reliability of some of the previously reported conclusions on adaptation in these proteins, as well as in similar studies of other species. The second chapter relates these alignment errors to specific regions in the proteins, the so-called intrinsically disordered protein regions. Disordered protein regions do not have a stable fold in native physiological conditions, and therefore do not fit the standard assumptions made in codon-based evolutionary analyses about structure and folding constraints. My findings indicate that in the case of the false-positively inferred positively selected sites, as well as in general throughout the alignments, most alignment errors and ambiguities originate in disordered regions. Indels in the alignments also appear predominantly in those regions. Examination of widely used alignment benchmarks indicates that disordered regions have mostly been excluded from the benchmarks. I discuss implications of these findings for both evolutionary research and development of alignment software. The last chapter of my dissertation characterizes the evolution of disordered regions in Drosophila. I survey protein substitution and polymorphism patterns in D. melanogaster and D. simulans, and find that relative to structured regions, disordered ones have multiple-fold higher rates of replacement polymorphisms and substitutions, as well as fewer rare polymorphisms. Structured regions appear to be significantly more impacted by both positive and purifying selection, contrary to indications from previous reports where within-species data was not incorporated in the analysis.
  • 2009 Springer
    Vishvanath Nene, Chittaranjan Kole, editors.
  • 2008 Springer
    Wayne Hunter, Chittaranjan Kole (editors).
    Honeybee / D. Schlipalius, P.R. Ebert, G.J. Hunt -- Bumblebee / L. Wilfert, P. Schmid-Hempel, J. Gadau -- The jewel wasp - Nasonia / J. Gadau ... [et al.] -- Silkworm / Y. Yasukochi, H. Fujii, M.R. Goldsmith -- Pea aphid / J.A. Brisson, G.K. Davis -- Mosquito / D.W. Severson -- Hessian fly / J.J. Stuart, M.-S. Chen, M.O. Harris -- Tick / A.J. Ullmann, J.J. Stuart, C.A. Hill.
  • 2008 Springer
    Thomas D. Kocher, Chittaranjan Kole (editors).
  • 2012 Springer
    Paul Denny, Chittaranjan Kole, editors.
    Genomics in the sea urchin : new perspectives on a perennial model system / Katherine M. Buckley amd Jonathan P. Rast -- Genome mapping and genomics of Caenorhabditis elegans / Jonathan Hodgkin, Michael Paulini, and mary Ann Tuli -- Genome mapping and genomics in Drosophila / Boris Adryan and Steven Russell -- Genome structure, functional genomics, and proteomics in ascidians / Yasunori Sasakura, Nicolas Sierro, Kenta Nakai, Kazuo Inaba, and takehiro G. Kusakabe -- Punching above their weight : the compact genomes of pufferfishes / Brian Cusack and Hugues Roest Crollius -- Medaka genomics and the methods and resources for decoding genomic functions / Tetsuaki Kimura, Yasuhiro Kamei, Yusuke Takehana, Takao Sasado, and Kiyoshi Naruse -- Xenopus genomics and genetics : progress and prospects / Amy K. Sater and Michael J. Gilchrist -- Mouse genome mapping and genomics / Paul Denny -- Rat genome mapping and genetics / Claude Szpirer and Göran Levan.
  • 2010 Springer
    Heinz Peter Nasheuer, editor.
    Coming full circle: Cyclin-dependent kinases as anti-cancer drug targets / R.P. Fisher -- Core and linker histone modifications involved in the DNA damage response / J.E. Chubb and S. Rea -- Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56 / T. Costelloe and N.F. Lowndes -- Structure and function of histone H2AX / D.M. Pinto and A. Flaus -- The initiation step of eukaryotic DNA replication / H. Pospiech, F. Grosse and F.M. Pisani -- Non-coding RNAs: New players in the field of eukaryotic DNA replication / T. Krude -- Function of TopBP1 in Genome Stability / M. Sokka ... [et al.] -- Eukaryotic single-stranded DNA binding proteins: central factors in genome stability / S. Broderick ... [et al.] -- DNA polymerases and mutagenesis in human cancers / E. Crespan, A. Amoroso and G. Maga -- DNA polymerase [eta], a key protein in translesion synthesis in human cells / S. Cruet-Hennequart ... [et al.] -- The mitochondrial DNA polymerase in health and disease / W.C. Copeland -- Centromeres: assembling and propagating epigenetic function / M. Glynn ... [et al.] -- Nucleotide excision repair in higher eukaryotes: mechanism of primary damage recognition in global genome repair / N.I. Rechkunova and O.I. Lavrik -- Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans / M.R. Lieber ... [et al.] -- Fluorescence-based quantification of pathway-specific DNA double-strand break repair activities: a powerful method for the analysis of genome destabilizing mechanisms / M. Bohringer and L. Wiesmuller -- Apoptosis: a way to maintain healthy individuals / C. Mondello and A.I. Scovassi -- The use of transgenic mice in cancer and genome stability research / S. Conmy and H.P. Nasheuer.
  • 2007
    T.A. Brown.
    Status: Not Checked OutLane Catalog Record
    Genomes, transcriptomes, and proteomes -- Studying DNA -- Mapping genomes -- Sequencing genomes -- Understanding a genome sequence -- Understanding how a genome functions -- Eukaryotic nuclear genomes -- Genomes of prokaryotes and eukaryotic organelles -- Virus genomes and mobile genetic elements -- Accessing the genome -- Assembly of the transcription initiation comple -- Synthesis and processing of RNA -- Synthesis and processing of the proteome -- Regulation of genome activity -- Genome replication -- Mutations and DNA repair -- Recombination -- How genomes evolve -- Molecular phylogenetics.
  • 2006
    Serge Saxonov.
    Status: Not Checked OutLane Catalog Record
  • 2009/2010
    Brunner, Alayne Lisette.
    Status: Not Checked OutLane Catalog Record
  • 2005/2006
    Kathleen Hallisey Rubins.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer Protocols
    edited by Cedric Gondro, Julius van der Werf, Ben Hayes.
    "With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice."--Back cover
  • 2011
    Isoken Omosefe Airen.
    We set out to develop and apply a high-throughput cell-free protein synthesis (CFPS) platform that provides functional genomics information for a wide variety of open reading frames (ORFs). We then used this information to improve CFPS yields by 4- to 5-fold, depending on the protein product. With the increasing number of completed genome sequences and ongoing sequencing projects, the post-genomic era has ushered in the promise of complete understanding of biological systems. For such a task, the most important set of information is inarguably the knowledge of the function of each gene product. To lead this endeavor of discerning the properties and functions of the entirety of an organism's genes and gene products, the field of functional genomics has emerged. Functional genomics focuses on dynamic cellular aspects, such as gene transcription, translation, and protein-protein interactions, in attempts to understand the relationship between an organism's genome and its phenotype. Thus, the ultimate goal of such studies is to provide a more complete picture of how biological function arises from the hereditary information of a living system. However, despite this clear interest in analyzing the expression and function of gene products, the development of techniques to address the high-throughput needs of functional genomics has been challenging, given the large diversity of protein functions and physiochemical properties, such as molecular weight and hydrophobicity, as well as the varying expression levels of proteins within a cell. In light of these challenges, we developed a sequential CFPS platform, which is capable of characterizing a variety of diverse proteins in the context of the dynamic metabolic networks that exist in vivo. The first round of expression is directed by PCR-generated expression templates (ETs) and creates an array of cell extracts that are individually enriched with a single target gene product. This round of CFPS is terminated by the selective degradation of the linear DNA templates, and a subsequent round of protein expression is initiated by the addition of a plasmid ET for a reporter protein. The array is then screened to identify gene products that enhanced or inhibited the expression and folding of the reporter. With such a method, we expect that the observations will expand our knowledge of both cell-free and in vivo metabolism, as well as identify key factors and reactions that could potentially lead to improved in vitro transcription, translation and protein folding. CFPS systems offer attractive alternatives to conventional fermentation processes used for protein production. Although improvements in CFPS energetics and reaction conditions have greatly enhanced in vitro protein synthesis, we believe that there are still other issues limiting the productivity of the technology. For this reason, identifying targets that could further improve CFPS is desirable. To validate the developed sequential CFPS protocol, we conducted a genome-wide survey of the well-studied bacterium Escherichia coli (E. coli) to identify soluble gene products that influence the in vitro metabolism. With this method, we identified 139 gene products (79 positive and 60 negative effectors) that influenced the cell-free transcription, translation, and protein folding of our three reporter proteins, as well as the energy metabolism and RNA and protein stability in the CFPS system. Encouragingly, most of the observed effects were consistent with the accepted in vivo metabolic functions of the gene products. However, many were not and required subsequent assays and in-depth literature searches to suggest hypotheses for the in vitro activities of the identified gene products. In many cases, the observations illuminated principles and influences that are unknown, lesser known, or secondary functions that were not expected to influence the CFPS performance. The information from the genome-wide survey was then used to guide modifications of the CFPS system to improve the productivity and duration of in vitro protein synthesis, as well as the efficiency of protein folding. First, fifteen positive effectors were produced and supplemented into the expression reactions in various combinations of the effectors in order to identify cooperative interactions that further enhance system performance. Next, we constructed and evaluated four mutant E. coli strains with chromosomal deletions in non-essential genes that encode negative effectors identified by the genomic survey. We also re-optimized the small molecule metabolite environment in the CFPS reactions. Thus, in the improved in vitro expression system, energy generation, translation initiation and elongation, and protein folding were enhanced; the reaction pH was stabilized; the supplies of specific molecular substrates that are essential for protein synthesis were replenished; and mRNA transcripts were stabilized. With this new system, the total, soluble, and active yields of the several diverse proteins were enhanced by 300 to 400%. The functional genomic analysis of E. coli has greatly broadened our understanding of the biology of the organism. And with the use of species-independent translational leaders that can facilitate cell-free expression (Mureev et al., 2009), our sequential CFPS platform can be used for similar genome-wide surveys of most organisms. In this way, the vast wealth of information available in the sequenced genomes will be utilized, and our knowledge of these biological systems will be significantly improved. Furthermore, the forward, or targeted, metabolic engineering strategy that was used to enhance our CFPS system can be applied to the development and/or improvement of most organism-based in vitro protein expression platforms. These targeted metabolic changes will lead to more rapid and more significant enhancements than traditional improvement strategies, as well as bring us closer to a complete understanding of the biological systems.
  • 2013 Springer
    Vijaykumar Yogesh Muley, Vishal Acharya.
    Introduction -- From genomes to protein functions -- Co-evolutionary signals within genome sequences reflect functional dependence of proteins -- Chromosomal proximity of genes as an indicator of functional linkage -- Analyses of complex genome-scale biological networks -- Application of protein interaction networks.
  • 2012
    Yue Wan.
    RNA plays an important role in regulating cellular gene expression. Its ability to fold into secondary and tertiary structures underlies the RNA's ability to function and be processed in every step of its life cycle, including transcription, splicing, cellular localization, translation and turnover of the RNA. However, structural information for most RNAs in the cells, such as mRNAs, is missing due to the low throughput nature of RNA structure probing and the traditional difficulty of probing long RNAs, making it difficult to assess the full impact of RNA structure in biology. To fulfill the need to understand the roles of RNA structure on a global scale, we developed for the first time a novel strategy termed Parallel Analysis of RNA Structure (PARS), which couples structure-specific probing to high throughput sequencing to simultaneously generate secondary structures for thousands of RNA species at single nucleotide resolution. Applying PARS to the yeast transcriptome identified distinct structural organization of mRNAs, including a three nucleotide periodicity in the coding region and increased accessibility near the start codon for translation. Furthermore, we demonstrated that PARS can be used to study dynamics by probing the yeast transcriptome across a temperature gradient to identify functional structural regions that have differential propensity to melt. PARS can be readily applied to different organisms and conditions, to identify structural determinants that regulate gene expression changes across organisms in different cellular states. This expansion of RNA structural data will likely enhance our understanding of how RNA structure translates into RNA function in cellular systems, as well as open doors to potentially targeting these structural elements to regulate cellular behavior in diseases.
  • 2013
    Lin Gan.
    Cells have an evolutionarily conserved mechanism to sense and integrate nutrient information for optimal growth and survival. The signaling network that is central to receiving nutritional inputs and translating them to effects on anabolic and catabolic activities of the cell consists of a large serine/threonine kinase known as mTOR. mTOR signaling is crucial for many important cellular processes such metabolism, growth, proliferation and differentiation. It is able to integrate diverse inputs including growth factors, cytokines, energy, oxygen and stress in addition to nutrients and regulate diverse outputs including translation, ribosome biogenesis, lipid biogenesis and autophagy. It is also an important therapeutic target and its inhibitor Rapamycin is currently being used or tested for a wide range of diseases including cancers and neurodegenerative diseases. Amino acids are arguably the most important regulators of mTOR and a long standing mystery in the field is the identity of the amino acid sensor and the mechanism of sensing. Using RNAi, we systematically screened through the human genome for candidate genes regulating amino acid signaling. We confirm that the mitochondria and the lysosomes are the two key sensing organelles, with amino acid metabolism and the RagGTPases being important for signal transduction. We identify a novel lysosomal 7 transmembrane protein that mediates signals upstream the RagGTPases and binds mTORC1-RagA in an amino-acid dependent manner. We also demonstrate that increasing levels of this protein enables cells to recruit mTOR to lysosomes and activate its kinase activity in the absence of amino acids. We show that GPR137B, mTORC1 and RagA form an amino acid sensitive, high-affinity binding complex at the lysosome. We propose a model of sensing where the 7-transmembrane protein, which we renamed to MORTOR, forms a tight complex with mTORC1-RagA in the presence of amino acids, resulting in the persistent lysosomal recruitment and activation of mTORC1. In addition to identifying novel regulators, this systematic study has also generated testable hypotheses about systems level properties of mTORC1 signaling, thus providing the foundation to understand mTOR signaling as a network. The discovery of the novel 7 transmembrane protein and its GPCR-like characteristics also has the potential to lead to new classes of therapeutics and targets for this important pathway.
  • 2010
    Renee Darlene Paulsen.
    Genome instability has long been known to be a hallmark of cancerous cells, but the cellular causes and consequences of such instability are still not fully understood. Mutations, translocations, DNA rearrangements, as well as chromosomal loss can all result in the loss of genomic integrity. To prevent the disruption of cellular homeostasis due to DNA damage accumulation, cells contain pathways to sense and respond to DNA damage including cell cycle checkpoints and numerous DNA repair processes, collectively known as the DNA damage response (DDR). Mutations in many of the genes involved in the DDR are linked to several diseases, including premature aging, neurodegeneration and cancer. These signaling pathways are especially critical during DNA replication when the DNA is unwound and vulnerable to processing. Here, the cell relies on the S-phase checkpoint to sense DNA damage at the sites of replication forks and to facilitate a number of downstream pathways to maintain genomic stability. These processes include blocking further origin firing, facilitating DNA repair, preventing cell cycle progression, and stabilizing stalled replication forks. Here, two genome-wide siRNA screens were employed to identify additional genes involved in genome stabilization by monitoring phosphorylation of the histone variant H2AX, an early mark of DNA damage. The first screen looked at H2AX phosphorylation that occurred simply by individual protein depletion, and the second screen used a low level of a replication inhibitor, aphidicolin, to specifically identify genes that were needed to prevent DNA damage during S-phase, potentially due to the loss of replication fork stabilization mechanisms. While the results from the second screen are still undergoing further characterization, we did discover hundreds of genes whose down-regulation led to elevated levels of H2AX phosphorylation in the absence of any external stress. From this gene set, we identified many gene networks that were significantly enriched amongst our screening hits as well as several intriguing individual genes that were chosen for follow up study. These included genes involved in mRNA processing, the pathology of Charcot-Marie-Tooth syndrome, and the histone methyl transferase protein, Set8.
  • 2007
    Elizabeth Danhwa Chao.
    Status: Not Checked OutLane Catalog Record
  • 2007/2008
    Nesanet Senaite Mitiku.
    Status: Not Checked OutLane Catalog Record
  • 2007
    John David Cahoy.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Evonne Chen Leeper.
    The neuron-restrictive silencer factor/RE-1 silencing transcription factor (NRSF/REST) is thought to be a negative regulator of neuronal genes in non-neuronal cells. However, evidence of its continued expression and activity in neurons suggests that NRSF may play other roles. A complete knowledge of NRSF target genes in neuronal and non-neuronal cells is the first step to understanding its functions. Using chromatin immunoprecipitation and quantitative PCR, I experimentally tested the occupancy of NRSF in living non-neuronal cells on 113 candidate binding sites predicted on the basis of conservation across the human, mouse, and dog genomes. These tests helped to further refine the prediction algorithm and identified a number of NRSF-bound regulatory microRNAs that may work in a feedforward loop to downregulate NRSF and its co-repressor, CoREST. I next focused on understanding NRSF recruitment in neuron-derived versus non-neuronal cell lines, using chromatin immunoprecipitation paired with ultrahigh-throughput sequencing (ChIP-seq) to get a direct, genome-wide picture of NRSF binding in human neuron-derived and non-neuronal cell lines. I found a large overlap in the NRSF binding pattern between the two cell types, particularly in binding sites found to be strongly or commonly bound. There is a subset of strong sites bound in all cell types, and weaker sites that are more likely to be cell-type specific. These common sites contain the canonical NRSE while the cell line unique sites do not. Finally, I used another ultrahigh-throughput sequencing based method to catalog and quantify all mRNA transcripts in each of the cell lines (RNA-seq) to add target gene expression to the analysis of NRSF function. Common target genes were more likely to be highly expressed in the neuron-derived cell line than in non-neuronal cell lines despite NRSF binding in both. I also found that the neuron-specific binding sites were primarily located in exons and promoters, while common or non-neuronal specific binding sites were primarily located in introns and intergenic regions. Differences in binding strength and target gene expression levels suggest that NRSF has different binding mechanisms and functions in neuron-derived and non-neuronal human cell lines.
  • 2009
    Melanie C. Bocanegra.
    Status: Not Checked OutLane Catalog Record
  • 2013 ClinicalKey
    edited by Geoffrey S. Ginsburg and Huntington F. Willard.
    This two-volume set provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine. Volume One Includes: Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care. Volume Two Includes: Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. * Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. * Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. * Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.
  • 2009 ScienceDirect
    edited by Huntington F. Willard and Geoffrey S. Ginsburg.
    v. 1. Principles, methodology, and translational approaches -- v. 2. Genome discoveries and clinical applications.
  • 2010
    Sarah Theresa Kerfoot Garcia.
    This thesis details the experimentation on three gene/gene families: the RE1-silencing transcription factor also known as neuron-restrictive silencer factor (REST/NRSF), a repressor of neuronal genes; maltase-glucoamylase (MGAM), the intestinal enzyme responsible for the breakdown of starch; and the neuronally expressed protocadherin gene family of unknown function (PCDH). The research I have completed is tied together by the fundamental question: how is diversity achieved? On the evolutionary scale, I have investigated the functional consequences of mutation and how these functional changes may have impacted the evolution of diversity. On the cellular scale, I have sought to understand how diversity is generated by attempting to define the binding networks of proteins important in the determination of cell fate in the case of REST/NRSF and in the determination of specific neuronal identities as the predicted function of the protocadherins. REST/NRSF is canonically known as a master repressor whose function is to establish and maintain the repression of neuronal genes in nonneuronal cells. While a handful of REST/NRSF target genes of neuronal function have been extensively studied, there is little consensus on the entire repertoire of REST/NRSF targets. I participated in the development of a set of software tools for transcription factors with known binding sites which allows the identification and characterization of binding sites and their potential target genes. We identified 660 putative target genes for REST/NRSF and demonstrated that this set is enriched for genes of known neuronal function and that the expression of REST/NRSF is negatively correlated with predicted target gene expression. We validated a large number of potential binding sites and experimentally determined a threshold value which enriches the set of predicted binding sites for true positive sites. Maltase glucoamylase (MGAM) is responsible for starch breakdown and is thought to be especially important in brain development when glucose demand is high. Other components of starch metabolism are known to have common variations which affect function and these high functioning variants are more common in populations with high starch diets. Research in our lab revealed a large, common deletion in the MGAM gene with a high allele frequency in Europeans, a population with comparatively increased starch intake. I mapped the endpoints of this large, common deletion and determined the likely mechanism by which the deletion occurred to be recombination between two highly similar repeats within the MGAM gene. I then demonstrated that the deletion has no gross impact on mRNA structure or expression in heterozygous form and is therefore likely to be a neutral mutation. The protocadherins are a diverse set of neuronally-expressed cell-adhesion-like molecules hypothesized to provide the molecular code necessary for the identification of individual neurons for their incorporation into appropriate neural circuits. I demonstrate that gene conversion events occur and have likely functional effects on protocadherin paralogs, a hypothesis that had only previously been supported by evolutionary evidence. Previous research suggested that endogenous cleavage products of some protocadherins localized to the nucleus and affected gene expression. I verified nuclear localization of the protocadherin paralogs previously published and demonstrated that this nuclear localization is a common feature of all protocadherin paralogs assayed. I found no evidence that the protocadherin fragment was capable of binding to DNA directly or to affect protocadherin expression, but was unable to determine whether this was indicative of a lack of these functions in vivo or a failure of my experimental system to detect them. I conclude that nuclear localization of protocadherin internal fragments is a process common to disparate members of the protocadherin cluster but the functional consequences of this nuclear localization remain unknown.
  • 2015 Springer
    George Jabboure Netto, Iris Schrijver, editor.
    Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist?s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
  • 2007 CRCnetBASE
    edited by William H. Benson and Richard T. Di Giulio.
    "Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
  • 2009
    Yingguang Frank Chan.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Daniel Jeffrey Kvitek.
    Adaptive evolution by natural selection is largely responsible for the variety of forms and functions observable in the natural world. Identifying the genetic changes underlying adaptive evolution of organisms to their environment is of fundamental importance in understanding the history of life, as well as predicting how organisms will evolve to novel environments in the future. Experimental evolution of microbes in the laboratory provides a precisely controlled environment for investigations into the genetic basis of adaptation, while also allowing for large population sizes and experimental replication, benefits that are often not available in natural populations. Recent technologies have enabled the identification of the genetic changes responsible for adaptive evolution genome-wide, giving us a genomic view of adaptation during evolution experiments. Here, I have added to our understanding of the genomic basis of adaptation by investigating how Saccharomyces cerevisiae adapts to limiting glucose environments during experimental evolution. Throughout this work, I utilize next- generation, whole-genome sequencing to identify the mutations responsible for adaptation. In Chapter 1, I investigate how genetic interactions define the fitness landscape, and find that very strong negative epistasis between two beneficial mutations creates a fitness valley, so each mutation effectively determines the evolutionary trajectory of adaptation. In Chapter 2, I take a step back and look more broadly at adaptation while asking the question: is there a general functional theme for the genomic basis of adaptation to limiting glucose? To facilitate answering this question in an unbiased manner, I develop a whole-population, whole-genome sequencing technique, and find that the theme of adaptation in the constant and predictable environment of the glucose-limited chemostat is for the yeast to lose function of signaling networks responsible for sensing environmental stimulus, effectively decoupling environmental sensing from response. In Chapter 3, in a collaborative project, we seek to understand the extent that genotypic convergence underlies phenotypic convergence by evolving genetically distinct yeast under different conditions. We find a single gene is recurrently mutated across most genetic backgrounds, suggesting that genotypic convergence plays a large role in adaptive evolution.
  • 2014 ScienceDirect
    edited by Yihong Yao, Bahija Jallal, Koustubh Ranade.
    Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases. Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs. Authored by leading international experts from industry and academia.
  • 2010
    Heather Elizabeth Wheeler.
    Although family studies have shown that genes play a role in longevity and tissue aging, it has proven difficult to identify the specific genetic variants involved. Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We developed a sequential transcriptional profiling and expression quantitative trait loci (eQTL) mapping approach known as genomic convergence to find genes associated with aging in the kidney. We first performed whole-genome transcriptional profiling to find 630 genes that change expression with age in the kidney. Next, we used two methods to determine which of these age-regulated genes are eQTLs, which means they contain SNPs whose alleles associate with expression level. We found that 101 of the age-regulated genes are eQTLs. We also found that the allele-specific eQTL detection method, which compares the mRNA levels of the two alleles within heterozygous individuals, was more sensitive than the total expression method in detecting allelic expression differences. We tested the eQTLs for association with kidney aging, measured by glomerular filtration rate (GFR) using combined data from the Baltimore Longitudinal Study of Aging (BLSA) and the InCHIANTI study. We found a SNP association (rs1711437 in MMP20) with kidney aging (uncorrected p = 3.6E-05, empirical p = 0.01) that explains 1-2% of the variance in GFR among individuals. The results of this sequential analysis may provide the first evidence for a gene association with kidney aging in humans. Our approach of combining both expression and genotype data can be applied to any phenotype of interest to increase the power to find genetic associations.
  • 2006 Springer
    edited by James R. Lupski, Paweł Stankiewicz.
    The CMT1A duplication: a historical perspective viewed from two sides of an ocean / James R. Lupski and Vincent Timmerman -- Alu elements / Prescott Deininger -- The impact of LINE-1 retrotransposition on the human genome / Amy E. Hulme ... [et al.] -- Ancient transposable elements, processed pseudogenes, and endogenous retroviruses / Adam Pavlicek and Jerzy Jurka -- Segmental duplications / Andrew J. Sharp and Evan E. Eichler -- Non-B DNA and chromosomal rearrangements / Albino Bacolla and Robert D. Wells -- Genetic basis of olfactory deficits / Idan Menashe, Ester Feldmesser, and Doron Lancet -- Genomic organization and function of human centromeres / Huntington F. Willard and M. Katharine Rudd -- Primate chromosome evolution / Stefan Müller -- Genome plasticity in evolution: the centromere repositioning / Mariano Rocchi and Nicoletta Archidiacono -- The CMT1A duplication and HNPP deletion / Vincent Timmerman and James R. Lupski -- Smith-Magenis syndrome deletion, reciprocal duplication dup(17)(p11.2p11.2), and other proximal 17p rearrangements / Paweł Stankiewicz, Weimin Bi, and James R. Lupski -- Chromosome 22q11.2 rearrangement disorders / Bernice E. Morrow -- Neurofibromatosis 1 / Karen Stephens -- Williams-Beuren syndrome / Stephen W. Scherer and Lucy R. Osborne -- Sotos syndrome / Naohiro Kurotaki and Naomichi Matsumoto -- X chromosome rearrangements / Pauline H. Yen -- Pelizaeus-Merzbacher disease and spastic paraplegia type 2 / Ken Inoue -- Y-chromosomal rearrangements and azoospermia / Matthew E. Hurles and Chris Tyler-Smith -- Inversion chromosomes / Orsetta Zuffardi ... [et al.] -- Monosomy 1p36 as a model for the molecular basis of terminal deletions / Blake C. Ballif and Lisa G. Shaffer -- Inv dup(15) and inv dup(22) / Heather E. McDermid and Rachel Wevrick -- Mechanisms underlying neoplasia-associated genomic rearrangements / Thoas Fioretos -- Recombination hotspots in nonallelic homologous recombination / Matthew E. Hurles and James R. Lupski -- Position effects / Paweł Stankiewicz -- Chromosome-engineered mouse models / Pentao Liu -- Array-CGH for the analysis of constitutional genomic rearrangements / Nigel P. Carter ... [et al.] -- Appendix A: Well-characterized rearrangement-based diseases and genome structural features at the locus / Paweł Stankiewicz and James R. Lupski -- Appendix B: Diagnostic potential for chromosome microarray analysis / Paweł Stankiewicz, Sau W. Cheung and Arthur L. Beaudet.
  • 2008 Springer
    edited by Jon F. Wilkins.
    DNA methylation reprogramming in the germ line / Diane J. Lees-Murdock and Colum P. Walsh -- Control of imprinting at the GNAS cluster / Jo Peters and Christine M. Williamson -- The GNAS locus and pseudohypoparathyroidism / Murat Bastepe -- Imprinted genes, postnatal adaptations, and enduring effects on energy homeostasis / Margalida Frontera ... [et al.] -- What are imprinted genes doing in the brain? / William Davies ... [et al.] -- Genomic imprinting and human psychology : cognition, behavior, and pathology / Lisa M. Goos and Gillian Ragsdale -- Genomic imprinting in plants / Olivier Garnier, Sylvia Laouiellé-Duprat, and Charles Spillane -- Imprinted genes and human disease : an evolutionary perspective / Francisco Úbeda and Jon F. Wilkins -- Evolutionary theories of imprinting ; enough already! / Tom Moore and Walter Mills.
    Also available: Print – 2008
  • 2012 Springer Protocols
    edited by Nora Engel.
    Uniparental embryos in the study of genomic imprinting / Yong Cheng, Dasari Amarnath, and Keith E. Latham -- Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species / Masanori Imamura [and others] -- Generation of trophoblast stem cells / Michael C. Golding -- Immunomagnetic purification of murine primordial germ cells / Emily Y. Smith and James L. Resnick -- Whole genome methylation profiling by immunoprecipitation of methylated DNA / Andrew J. Sharp -- Identification of imprinted loci by transcriptome sequencing / Tomas Babak -- Data mining as a discovery tool for imprinted genes / Chelsea Brideau and Paul Soloway -- Engineering of large deletions and duplications in vivo / Louis Lefebvre -- Methylated DNA immunoprecipitation (MeDIP) from low amounts of cells / Julie Borgel, Sylvain Guibert, and Michael Weber -- Chromatin immunoprecipitation to characterize the epigenetic profiles of imprinted domains / Purnima Singh and Piroska E. Szabo -- Quantitative chromosome conformation capture / Raffaella Nativio, Yoko Ito, and Adele Murrell -- Genome-wide analysis of DNA methylation in low cell numbers by reduced representation bisulfite sequencing / Sebastien A. Smallwood and Gavin Kelsey -- Isolation of RNA and DNA from single preimplantation embryos and a small number of mammalian oocytes for Imprinting Studies / Sarah Rose Huffman, Md Almamun, and Rocio Melissa Rivera -- Generation of cDNA libraries from RNP-derived regulatory noncoding RNAs / Mathieu Rederstorff -- Co-immunoprecipitation of long noncoding RNAs / Victoria A. Moran, Courtney N. Niland, and Ahmad M. Khalil -- Specialized technologies for epigenetics in plants / Wenyan Xiao -- Computational studies of imprinted genes / Martina Paulsen -- Insights on imprinting from beyond mice and men / Andrew Pask -- Nonmammalian parent-of-origin effects / Elena de la Casa-Esperon.
  • 2015 Springer
    Chris Maxwell, Cal Roskelley, editors.
    Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
  • 2008
    Jessica Parra.
    Status: Not Checked OutLane Catalog Record
  • 2001 ScienceDirect
    Eric H. Davidson.
    Also available: Print – 2001
  • 2007
    Jennifer Michelle Halbleib.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer Protocols
    edited by Lars Feuk.
    What have studies of genomic disorders taught us about our genome / Alexandra D. Simmons, Claudia M.B. Carvalho, and James R. Lupski -- Microdeletion and microduplication syndromes / Lisenka E.L.M. Vissers and Paweł Stankiewicz -- Structural genomic variation in intellectual disability / Rolph Pfundt and Joris A. Veltman -- Copy number variation and psychiatric disease risk / Rebecca J. Levy [and others] -- Detection and characterization of copy number variation in autism spectrum disorder / Christian R. Marshall and Stephen W. Scherer -- Structural variation in subtelomeres / M. Katharine Rudd -- Array-based approaches in prenatal diagnosis / Paul D. Brady [and others] -- Structural variation and its effect on expression / Louise Harewood, Evelyne Chaignat, and Alexandre Reymond -- Challenges of studying complex and dynamic regions of the human genome / Edward J. Hollox -- Population genetic nature of copy number variation / Per Sjodin and Mattias Jakobsson -- Detection and interpretation of genomic structural variation in mammals / Ira M. Hall and Aaron R. Quinlan -- Structural genetic variation in the context of somatic mosaicism / Jan P. Dumanski and Arkadiusz Piotrowski -- Online resources for genomic structural variation / Tam P. Sneddon and Deanna M. Church -- Algorithm implementation for CNV discovery using affymetrix and illumina SNP array data / Laura Winchester and Jiannis Ragoussis -- Targeted screening and validation of copy number variations / Shana Ceulemans, Karlijn van der Ven, and Jurgen Del-Favero -- High-resolution copy number profiling by array CGH using DNA isolated from formalin-fixed, paraffin-embedded tissues / Hendrik F. van Essen and Bauke Ylstra -- Characterizing and interpreting genetic variation from personal genome sequencing / Anna C.V. Johansson and Lars Feuk -- Massively parallel sequencing approaches for characterization of structural variation / Daniel C. Koboldt [and others].
  • 2008
    edited by Dhavendra Kumar ; advisory editor, Sir David Weatherall.
    Status: Not Checked OutLane Catalog Record
    From genes to genomes: a historical perspective -- The human genome: structure and organization -- Human function genomics and proteomics -- Epigenomics and human disease -- Genomic perspectives of human development -- Genetic and genomic approaches to taxonomy of human disease -- Genomic technologies -- Nutritional genomics -- Pharmacogenomics: drug development, drug response, and precision medicines -- Clinical medicine in the genome era: an introduction -- Complex cardiovascular disorders -- Diabetes mellitus and obesity -- Chronic renal disease -- Hemostasis and thrombosis -- Disorders of platelets -- Applications in critical care medicine -- The epilepsies -- Neurodegenerative disorders: tauopathies and synucleinopathies -- Neuropsychiatric diseases I: schizophrenia -- Neuropsychiatric disease II: mood disorders -- Asthma and chronic obstructive pulmonary disease -- Inflammatory bowel disease -- Genomics and cancer: mechanisms and applications -- Hematological malignancies: the paradigm of acute myeloid leukemia -- Genomics and infectious diseases: susceptibility, resistance, antimicrobial therapy -- Rheumatoid arthritis and related arthropathies -- Immunological disorders -- Applications in clinical pediatrics -- Learning and behavioral disorders -- Complex ophthalmic disorders -- Applications in audiological medicine -- Complex skin diseases I: psoriasis -- Complex skin diseases II: atopic dermatitis -- Diseases of the epidermis and appendages, skin pigmentation and skin cancer -- Osteoporosis and disorders -- Applications in obstetrics and gynecology and reproductive medicine -- Stem cell genomics, and regenerative medicine -- Genomics and global health -- Genetic testing and genomic screening -- Ethical, legal, and social issues (ELSI) -- The regulation of human genomics research.
  • DOE Human Genome Program
  • 2008 Springer
    edited by Federico Innocenti.
    Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.
  • 2014 Springer
    György Marko-Varga, editor.
    This book offers a valuable resource that allows students, researchers, educators and the general public to learn about proteomics and genomics. Chromosomes form the basis for our genetic heritage and are the code for protein synthesis. The Human Genome Map was presented in 2002, and the Proteome Sequence Map is currently being created by a global consortia initiative. Proteome and genome building blocks already form the basis of scientific research areas and shape major areas of the pharmaceutical and biomedical industries. The book provides background information on and our current understanding of these gene and protein areas, and explains in detail how cutting-edge science is using these resources to develop new medicines and new diagnostics for patient treatment and care. The book will benefit all students and researchers who need a good understanding of genomics and proteomics within the clinical field. Its content is also suitable for a broad readership, including those not specialized in this field. Dr. Marko-Varga is head of Div. Clinical Protein Science & Imaging at the Biomedical Center, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University. He's also Professor at the 1st Department of Surgery, Tokyo Medical University, Tokyo, Japan.
  • 2008 Springer
    edited by Stuart Handwerger, Bruce J. Aronow.
    Microarray-based gene expression analysis of endocrine systems: principles of experimental design and interpretation. -- Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblastic cells. -- Analysis of growth hormone effects on hepatic gene expression in hypophysectomized rats. -- Gene expression profiling in leiomyoma in response to GnRH therapy and TGF-beta. -- Gene profiling analysis of androgen receptor mediated function. -- Interrogating estrogen receptor [alpha] signaling in breast cancer by chromatin immunoprecipitation microarrays. -- Gene expression analysis of the adrenal cortex in health and disease. -- DNA microarray analysis of human uterine decidualization. -- Large-scale DNA microarray data analysis reveals glucocorticoid receptor-mediated breast cancer cell survival pathways. -- Application of microarrays for gene transcript analysis in type 2 diabetes. -- DNA microarray analysis of effects of TSH, iodide, cytokines, and therapeutic agents on gene expression in cultured human thyroid follicles. -- Genomics and polycystic ovary syndrome (PCOS): the use of microarray analysis to identify new candidate genes. -- Microarray analysis of alterations induced by obesity in white adipose tissue gene expression profiling. -- Novel molecular signaling and classification of human clinically nonfunctioning pituitary adenomas identified by microarray and reverse transcription-quantitative polymerase chain reaction. -- Gene expression studies of prostate hyperplasia in prolactin transgenic mice.
  • 2008 CRCnetBASE
    edited by Gerald T. Ankley ... [et al.].
    Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.]. Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
  • 2008 Springer
    J.P. Gustafson, J. Taylor, and G. Stacey, editors.
  • 2013 Springer
    Anton G. Kutikhin, Arsenij E. Yuzhalin.
    The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
  • 2011 Springer
    James D. Clelland, editor.
    Complex behaviours are the product of intercellular signalling events, but their intracellular effectors are present in most cell types. The best-studied example of such architecture is the circadian clock, which directs all diurnal behaviour and physiology, and whose central mechanism is present in most body cells. We present below a method to look at its properties via transcriptional reporters virally delivered to primary cells. By studying primary fibroblasts cultivated from skin biopsies in different human subjects, we have been able to analyse the molecular underpinnings of variance in human daily behaviour. Similar methodologies could be applied to other signalling pathways.
  • 2008 Springer Protocols
    edited by Mike Starkey, Ramnath Elaswarapu.
    Protein profiling based on two-dimensional difference gel electrophoresis / Gert Van den Bergh and Lutgarde Arckens -- Quantitative protein profiling by mass spectrometry using isotope-coded affinity tags / Arsalan S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Quantitative protein profiling by mass spectrometry using label-free proteomics / Arsala S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Using 2D-LC-MS/MS to identify Francisella tularensis peptides in extracts from an infected mouse macrophage cell line / John F. Kelly and Wen Ding -- Baculovirus expression vector system : an emerging host for high-throughput eukaryotic protein expression / Binesh Shrestha, Carol Smee, and Opher Gileadi -- Coimmunoprecipitation and proteomic analyses / S. Fabio Falsone, Bernd Gesslbauer, and Andreas J. Kungl -- Tandem affinity purification combined with mass spectrometry to identify components of protein complexes / Peter Kaiser ... [et al.] -- Mammalian two-hybrid assay for detecting protein-protein interactioins in vivo / Runtao He and Xuguang Li -- Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation / Victor Villalobos, Snehal Naik, and David Piwnica-Worms -- Subcellular localization of intracellular human proteins by construction of tagged fusion proteins and transient expression in COS-7 cells / John E. Collins -- GeneFAS : a tool for the prediction of gene function using multiple sources of data / Trupti Joshi ... [et al.] --Comparative genomics-based prediction of protein function / Toni Gabaldón -- Design, manufacture, and assay of the efficacy of siRNAs for gene silencing / Louise A. Dawson and Badar A. Usmani. Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield / Kaisa Silander and Janna Saarela -- Scanning for DNA variants by denaturant capillary electrophoresis / Per O. Ekstrøm -- Identification of SNPs, or mutations in sequence chromatograms / Nicole Draper -- BeadArray-based genotyping / Helen Butler and Jiannis Ragoussis -- Microsattelite-based candidate gene linkage analysis studies / Cathryn Mellersh -- Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH) / Alexei Protopopov, Bin Feng, and Lynda Chin -- Detection of copy number changes at multiple loci in DNA prepared from formalin-fixed, paraffin-embedded tissue by multiplex ligation -dependent probe amplification / Minoru Takata -- Application of microarrays for DNA methylation profiling / Axel Schumacher, Andreas Weinhäusl, and Arturas Petronis -- Genomewide identification of protein binding locations using chromatin immunoprecipitation coupled with microarray / Byung-Kwan Cho, Eric M. Knight, and Bernhard Ø. Palsson -- Transcriptional profiling of small samples in the central nervous system / Stephen D. Ginsberg -- Quantitative expression profiling of RNA from formalin-fixed, paraffin-embedded tissues using randomly assembled bead arrays / Marina Bibikova ... [et al.] -- Expression profiling of microRNAs in cancer cells : technical considerations / Mouldy Sioud and Lina Cekaite -- Identification of disease biomarkers by profiling of serum proteins using SELDI-TOF mass spectrometry / Sigrun Langbein -- The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease / Peter Ellmark ... [et al.] --
  • 2012
    Eric Lyman Van Nostrand.
    Although the development of high-throughput techniques to quantify gene expression have enabled us to characterize genes that change in various conditions, identifying the regulators that drive these changes remains a challenging problem. Recent efforts to identify direct transcription factor targets provide a foothold to addressing the identification of regulators, by allowing inference of critical factors based on the expression patterns of their targets. However, success in this approach requires an improved ability to infer factor-responsive targets (those regulated by the transcription factor) from direct targets (those bound by the factor). By identifying factor-specific binding sites (i.e., those regions bound by the factor of interest but not by many additional random transcription factors), we found that the link between direct and functional targets was significantly improved -- e.g., although only 26% of significant HLH-1 binding sites correlated with altered expression when HLH-1 was over-expressed, over 40% of factor-specific significant binding sites did so. In the course of this work, we identified HOT (Highly Occupied Target) regions that were bound by more than 65% of factors assayed. Surprisingly, our analysis indicated that these regions were not artifacts of the target identification methodology. Rather, they instead indicate a potentially novel regulatory mechanism for expression of housekeeping genes, as genes associated with HOT regions were highly and ubiquitously expressed and essential for development. Next, we applied this approach to the study of aging. Although genome-wide microarray experiments in C. elegans have identified over a thousand genes with age-dependent expression, only a handful of transcriptional regulators are known to link altered lifespan with modulation of genes that change during wild-type aging. We describe an approach to infer potential regulators of aging and longevity by interrogating direct transcription factor targets generated by the modENCODE project. We identify nine factors with targets significantly enriched for altered expression with age, including three previously shown to modulate lifespan. We further show that for two additional factors, NHR-28 and NHR-76, strains in which these factors are over-expressed show increased lifespan, suggesting that these factors may represent additional links between age-dependent gene expression changes with longevity. This approach identified HOX co-factor unc-62 (Homothorax) as a developmental regulator that binds age-regulated transcripts and modulates lifespan. In the intestine (in which UNC-62 knockdown increases lifespan) we identify multiple activities: UNC-62 binds to and activates both intestine-expressed yolk protein genes that decline with age as well as neuronal-enriched genes that increase in intestinal expression with age. An alternatively spliced, tissue-specific isoform of unc-62 is expressed exclusively in the intestine and declines with age, providing a potential mechanism for distinct activities of UNC-62 between tissues and stages. Thus, UNC-62 provides a proof of principle for uncovering unexplored transcription factors effecting aging and longevity through integrated analysis of developmental regulatory targets.
  • 2014 Springer Protocols
    edited by L. María Sierra, Isabel Gaivão.
    Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
  • 2013 Springer Protocols
    edited by Alok Dhawan, Mahima Bajpayee.
    Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
  • 2006
    Alan C. Acock.
  • 2007 Springer
    edited by Robert D. Perry and Jacqueline D. Fetherston.
    "The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field."--Preface.
    Also available: Print – 2007
  • 2008 CRCnetBASE
    [edited by] Gerard Rushton ... [et al.].
  • 2008 Springer
    Jeffrey H. Silverstein, G. Alec Rooke, J.G. Reves, Charles H. McLeskey, editors.
    The practice of geriatric anesthesia / Jeffrey H. Silverstein -- Demographics and economics of geriatric patient care / Maria F. Galati and Roger D. London -- Theories of aging / Stanley Muravchick -- Ethical management of the elderly patient / Paul J. Hoehner -- Teaching geriatric anesthesiology to practitioners, residents, and medical students / Sheila J. Ellis -- Research priorities in geriatric anesthesiology / Christopher J. Jankowski and David J. Cook -- Alterations in metabolic functions and electrolytes / Michael C. Lewis -- Perioperative thermoregulation / Daniel I. Sessler -- Postoperative central nervous system dysfunction / Deborah J. Culley, Terri G. Monk, and Gregory Crosby-- Alterations in circulatory function / Thomas J. Ebert and G. Alec Rooke -- The aging respiratory system : anesthetic strategies to minimize perioperative pulmonary complications / Rodrigo Cartin-Ceba ... [et al.] -- Operative debridements of chronic wounds / Andrew M. Hanflik ... [et al.] -- Preoperative risk stratificationand methods to reduce risk / Linda L. Liu and Jacqueline M. Leung -- Anesthetic implications of chronic medications / Tamas A. Szabo and R. David Warters -- The pharmacology of opioids / Steven L. Shafer and Pamela Flood -- Intravenous hypnotic anesthetics / Matthew D. McEvoy and J.G. Reves -- Inhalational anesthetics / Gary R. Haynes -- Relaxants and their reversal agents / Cynthia A. Lien and Takahiro Suzuki -- Management of regional anesthesia / Bernadette Veering -- Fluid management / Jessica Miller, Lee A. Fleisher, and Jeffrey L. Carson -- Pain management / Jack M. Berger -- Anesthesia considerations for geriatric outpatients / Kathryn E. McGoldrick -- Sedaton and monitoring / Sheila R. Barnett -- Total hip replacement, joint replacement, and hip fracture / Idit Matot and Shaul Beyth -- Transurethral prostatectomy syndrome and other complications of urologic procedures / Daniel M. Gainsburg -- Thoracic procedures / Steven M. Neustein and James B. Eisenkraft -- Cardiac procedures / James H. Abernathy III -- Vascular procedures / Leanne Groban and Sylvia Y. Dolinski -- Abdominal procedures / Jeffrey H. Silverstein.
  • 2008
    Jeffrey H. Silverstein, G. Alec Rooke, J.G. Reves, Charles H. McLeskey, editors.
    Status: Not Checked OutLane Catalog Record
  • 2015 Wiley
    Iona Murdoch, Sarah Turpin, Bree Johnston, Alasdair MacLullich, Eve Losman.
    Introduction to geriatric emergency medicine -- Essentials of assessment and management in geriatric emergency medicine -- Special skills in geriatric emergency medicine -- Vulnerable adults and elder abuse -- Chest pain and atrial fibrillation -- Dyspnoea -- Infection and sepsis -- Falls and immobility -- Syncope -- Dizziness -- Major trauma -- Fractures and back pain -- Skin trauma -- Head injury -- Abdominal emergencies -- Diabetic and environmental emergencies -- Acute kidney injury and metabolic emergencies -- Delirium -- Stroke and transient ischaemic attack.
  • 2014 Cambridge
    edited by Joseph H. Kahn, Brendan G. Magauran Jr., Jonathan S. Olshaker.
    Overview of geriatric emergency medicine -- The geriatric emergency department -- General approach to the geriatric patient -- Resuscitation of the elderly -- Pharmacology in the elderly -- Generalized weakness in the elderly -- Management of trauma in the elderly -- Pain management in the elderly -- Chest pain in the elderly -- Dyspnea in the elderly -- Abdominal pain in the elderly -- Altered mental status in the elderly -- Syncope in the elderly -- Dizziness in the elderly -- Headache in the elderly -- Back pain in the elderly -- Eye, ear, nose, and throat emergencies in the elderly -- Neurological emergencies in the elderly -- Pulmonary emergencies in the elderly -- Cardiovascular emergencies in the elderly -- Gastrointestinal emergencies in the elderly -- Genitourinary and gynecologic emergencies in the elderly -- Rheumatologic and orthopedic emergencies in the elderly -- Infectious diseases in the elderly -- Hematologic and oncologic emergencies in the elderly -- Psychiatric emergencies in the elderly -- Metabolic and endocrine emergencies in the elderly -- Alternative geriatric care and quality metrics -- Functional assessment of the elderly -- Palliative and end-of-life care in the emergency department -- Social services and case management -- Falls and fall prevention in the elderly -- Financial issues in geriatric emergency care -- Elder mistreatment
  • 2016 Springer
    Jennifer L. Hayashi, Bruce Leff, editors ; Linda DeCherrie, Theresa A. Soriano, associate editors.
    This book is a practical reference for any clinician who has struggled to care for an older adult in a home setting. The volume is written by experts in the field who describe fundamental principles and clinical approaches of geriatric home-based care and their application to specific diseases and conditions, including delirium, incontinence, falls, and chronic pain and disability. The book also details house calls for special populations, from the developmentally disabled to those afflicted with neurologic or psychiatric diseases. The volume explores house calls within the context of the US healthcare system. Geriatric Home-Based Medical Care: Principles and Practice is a valuable resource for geriatricians, geriatric nurses, primary care physicians, social workers, public health officials, and all medical professions who need tools to provide timely, compassionate, and high-quality care for their older adult patients.
  • 2013 Springer
    Giuseppe Guglielmi, Wilfred C.G. Peh, Ali Guermazi, editors.
    In the elderly, the coexistence of various diseases, the presence of involutional and degenerative changes, and the occurrence of both physical and cognitive problems represent ""the norm."" It is therefore important to know how to distinguish the healthy elderly from those in need of treatment as a sound basis for avoiding overdiagnosis and overtreatment. This aspect is a central theme in Geriatric Imaging, which covers a wide range of applications of different imaging techniques and clearly explains both the potential and the limitations of diagnostic imaging in geriatric patients.
  • 2014 Wiley
    edited by Anil K. Nair and Marwan N. Sabbagh.
    Part 1. The aging brain in neurology -- part 2. Assessment of the geriatric neurology patient -- part 3. Neurologic conditions in the elderly -- part 4. Therapeutics for the geriatric neurology patient -- part 5. Important management issues beyond therapeutics in the geriatric neurology patient.
  • 2007 CRCnetBASE
    edited by John E. Morley, David R. Thomas.
    1. The aging society and nutrition epidemiology / Shailaja Pulisetty and John E. Morley -- 2. Molecular theories of aging and nutritional interventions / H.J. Armbrecht -- 3. The role of nutrition in the prevention of age-associated diseases / John E. Morley -- 4. Obesity in older adults / Gary A. Wittert -- 5. Sarcopenia and cachexia / John E. Morley and Matthew T. Haren -- 6. Immunity and nutrition / Chantri Trinh -- 7. Nutritional requirements in older adults / David R. Thomas -- 8. Energy balance / John E. Morley -- 9. Water metabolism / David R. Thomas and John E. Morley -- 10. Vitamin disorders / Ramzi R. Hajjar and Zeina Nahhas -- 11. Trace elements / John E. Morley -- 12. Nutritional assessment in older persons / David R. Thomas -- 13. Geriatric assessment and its interaction with nutrition / Julie K. Gammack -- 14. Nutritional assessment in the European community / Juergen Martin Bauer and Dorothee Volkert -- 15. The oral cavity and nutrition / Nathalia Garcia and D. Douglas Miley -- 16. Management of protein-energy undernutrition in older adults / David R. Thomas -- 17. Prescription for enteral nutrition / Zareen Syed and Syed H. Tariq.
  • 2009 Springer
    editors Arti Hurria and Lodovico Balducci.
    Aging and cancer, what oncologists need to know / Arti Hurria, Lodovico Balducci -- Assessing the older cancer patient / Melissa Cohen, David Reuben, Arash Naeim -- Cancer screening in older adults / Louise C. Walter -- Physiological consequences of aging / Bindu Kanapuru, William B. Ershler -- Assessment and impact of comorbidity in older adults with cancer / Athanasios Karampeasiz, Martine Extermann -- Geriatric syndromes defined and explained for oncology practice / Miriam B. Rodin -- Family caregivers / Betty R. Ferrell, Polly Mazanec -- Surgical management of the older patient with cancer / David M. Heimann, M. Margaret Kemeny -- Chemotherapy for the older adult with cancer / Supriya Mohile, Nail Nagovskiy, Lodovico Balducci -- Radiation therapy in geriatric oncology / Sarah E. Hoffe, Mark S. Russell -- Palliative care, special considerations for older adults with cancer / Genevieve N. Thompson, Harvey M. Chochinov.
  • 2009 Springer
    Andrew G. Lee and Hilary A. Beaver, editors.
    Scope of the problem and demographic shift in population: visual disease incidence and prevalence in the elderly population -- Refractive error in the geriatric population -- Cataracts and cataract surgery -- Glaucoma in the elderly -- Diabetic retinopathy and its management -- Age-related macular degeneration and its management -- Low vision: when vision fails -- Visual loss and depression -- Visual loss and dementia -- Visual loss and hearing loss -- Visual loss and falls -- Elder abuse -- Functional impairment and visual loss -- The research agenda-setting project (RASP) -- Screening for comorbidities -- Refer comorbidities.
  • 2015 Thieme-Connect
    [edited by] Robert T. Sataloff, Michael M. Johns III, Karen M. Kost.
    The science of aging / Alessandro Bitto, Chad A. Lerner, and Christian Sell -- Geriatric otolaryngology : an overview / Karen M. Kost -- Understanding geriatric syndromes, the geriatric interdisciplinary team, and resources to optimize care for older patients / Sarah H. Kagan -- Evaluation of the outpatient geriatric patient / David Eibling -- Operative evaluation of the geriatric patient / Natalie Justicz and Jeanne Hatcher -- Age-related hearing loss / Kourosh Parham, Frank R. Lin, and Brian W. Blakley -- Regenerative therapies for sensorineural hearing loss : current research implications for future treatment / Cynthia L. Chow and Samuel P. Gubbels -- Hearing aids : considerations in the geriatric population / Amanda Kantor, Erica Miele, John Luckhurst, Mary Hawkshaw, and Robert T. Sataloff -- Cochlear implantation in the elderly / Daniel H. Coelho and Brian J. McKinnon -- Subjective idiopathic tinnitus in the geriatric population / Paul F. Shea and Brian J. McKinnon -- Dizziness, imbalance, and age-related vestibular loss in the geriatric population / Yuri Agrawal, Allan Rubin, and Stephen J. Wetmore -- Sinonasal disease in the elderly / David R. Edelstein -- Taste and smell in the elderly / Richard L. Doty and Hussam Tallab -- Inhalant allergies and asthma in the geriatric population / Karen H. Calhoun -- Voice disorders in the elderly / Robert T. Sataloff and Karen M. Kost -- Swallowing disorders in the elderly / Ozlem E. Tulunay-Ugur -- Sleep disturbance in the geriatric population / Christopher G. Larsen and M. Boyd Gillespie -- Facial plastic surgery in geriatric patients / J. Regan Thomas -- Oral cavity disorders in geriatric patients / Elliot Regenbogen and Denise A. Trochesset -- Advanced cutaneous malignancies in the elderly / Kelly Michele Malloy and Chaz L. Stucken -- Head and neck cancer in the elderly / Mihir R. Patel, Raymond L. Chai, and Ara A. Chalian -- The role of neuropsychology in the evaluation and treatment of geriatric patients / Thomas Swirsky-Sacchetti and Caterina B. Mosti.
  • 2012 ScienceDirect
    [edited by] Andrew Guccione, Rita A. Wong, Dale Avers.
    Geriatric Physical Therapy offers a comprehensive presentation of geriatric physical therapy science and practice. Thoroughly revised and updated, editors Andrew Guccione, Rita Wong, and Dale Avers and their contributors provide current information on aging-related changes in function, the impact of these changes on patient examination and evaluation, and intervention approaches that maximize optimal aging. Chapters emphasize evidence-based content that clinicians can use throughout the patient management process. Six new chapters include: Exercise Prescription, Older Adults and Their Families, Impaired Joint Mobility, Impaired Motor Control, Home-based Service Delivery, and Hospice and End of Life. Clinically accurate and relevant while at the same time exploring theory and rationale for evidence-based practice, it's perfect for students and practicing clinicians. It's also an excellent study aid for the Geriatric Physical Therapy Specialization exam. Comprehensive coverage provides all the foundational knowledge needed for effective management of geriatric disorders. Content is written and reviewed by leading experts in the field to ensure information is authoritative, comprehensive, current, and clinically accurate. A highly readable writing style and consistent organization make it easy to understand difficult concepts. Tables and boxes organize and summarize important information and highlight key points for quick reference. A well-referenced and scientific approach provides the depth to understand processes and procedures. Theory mixed with real case examples show how concepts apply to practice and help you enhance clinical decision-making skills. Standard APTA terminology familiarizes you with terms used in practice.
  • 2011 Springer
    Yuri Nakasato, Raymond L. Yung, editors.
    Part 1. Aging and Comorbidity in Rheumatology -- The Immune System in Aging / Anjali Desai and Raymond L. Yung -- Bone Aging / Arthur N. Lau and Jonathan D. Adachi -- Atherosclerosis in the Rheumatic Diseases: Compounding the Age Risk / Naoto Yokogawa and Joan M. Von Feldt -- Neuropsychiatric Manifestations of Rheumatic Diseases in the Elderly / Jamal A. Mikdashi -- Tuberculosis and Rheumatoid Arthritis in the Elderly / Eduardo M. Acevedo-Vásquez, Darío Ponce de León and Rocío V. Gamboa-Cárdenas -- Widespread Pain in Older Adults / Cheryl D. Bernstein, Jordan F. Karp and Debra K. Weiner -- Part 2. Multidisciplinary Approach to Geriatric Rheumatology -- Pharmacotherapy Considerations Unique to the Older Patient / Keith A. Swanson and Mark A. Stratton -- Rheumatic Disease in the Nursing Home Patient / Joanne Sandberg-Cook -- Post-acute Care for Rheumatologists / Deborah W. Robin -- The Gerontorheumatology Outpatient Service: Toward an International Classification of Function-Based Health Care Provision for the Elderly with Musculoskeletal Conditions / Wim Van Lankveld, Josien Goossens and Marcel Franssen -- Health Policy, Public Health, and Arthritis Among Older Adults / Kristina A. Theis, Debra R. Lubar and Teresa J. Brady -- Physical Therapy Management of Select Rheumatic Conditions in Older Adults / Maura Daly Iversen and Madhuri K. Kale -- Arthrocentesis in the Elderly / Ahmed S. Zayat and Richard J. Wakefield -- Physical Activity in Older Adults with Arthritis / Dorothy D. Dunlop, Pamela A. Semanik and Rowland W. Chang -- Part 3. Rheumatic Diseases in the Elderly -- Systemic Lupus Erythematosus in Elderly Populations / Ana M. Bertoli, Guillermo J. Pons-Estel, Paula I. Burgos and Graciela S. Alarcón -- Elderly Onset Rheumatoid Arthritis / Venkata Sri Cherukumilli and Arthur Kavanaugh -- Disease-Modifying Antirheumatic Drug Use in Older Rheumatoid Arthritis Patients / Sogol S. Amjadi, Veena K. Ranganath and Daniel E. Furst -- Epidemiology, Risk Factors, and Aging of Osteoarthritis / Crisostomo Bialog and Anthony M. Reginato -- Osteoarthritis in the Elderly Population / Roy D. Altman -- Medium- and Small-Vessel Vasculitis / Rafael G. Grau -- Management of Geriatric Gout / Lan X. Chen -- Calcium-Containing Crystal-Associated Arthropathies in the Elderly Population / Elisabeth B. Matson and Anthony M. Reginato -- Polymyalgia Rheumatica and Giant Cell Arteritis in the Elderly / Wolfgang A. Schmidt -- Antiphospholipid Syndrome in the Older Population / Silvia S. Pierangeli, Alan M. Seif and Emilio B. González -- Osteoporosis and Metabolic Bone Diseases of the Elderly / Lora Giangregorio and Alexandra Papaioannou -- Infectious Arthritis in the Elderly / Nicole Melendez and Luis R. Espinoza -- Sarcopenia and Myopathies in the Elderly / Kenneth S. O'Rourke -- Scleroderma in the Elderly Population / Rebecca L. Manno and Fredrick M. Wigley -- Sjögren's Syndrome in the Elderly / Raymond L. Yung and Sheeja Francis.
  • 2014 Springer
    edited by Jay A. Yelon, Fred A. Luchette.
    Geriatric Trauma and Critical Care provides a multidisciplinary overview of the assessment and management of the elderly patient presenting with surgical pathology. By utilizing current literature and evidence-based resources, the textbook elucidates the unique nature of caring for the elderly population. The structure of the volume provides the reader with an overview of the physiologic and psychological changes, as well as the impact on the healthcare system, associated with the aging process. Emphasis is placed on the impact of aging, pre-existing medical problems, effects of polypharmacy, advanced directives and end-of-life wishes on acute surgical problems, including trauma and surgical critical care. Special attention is given to the ethical implications of management of the aged. The multidisciplinary contributors provide a unique point of view not common to surgical texts. The textbook is the definitive resource for practicing surgeons, emergency medicine physicians, intensivists, anesthesiologists, hospitalists, geriatricians, as well as surgical residents, nurses and therapists, all who care for elderly patients with surgical emergencies.
  • 2014 Springer
    Tomas Lindor Griebling, editor.
    Geriatric urology represents one of the largest overall sectors of care provided within the specialty of urology. As the incidence and prevalence of many clinical urologic conditions increase significantly in older adults, the practice of urology involves a need for advanced knowledge of the basic principles of geriatrics. Geriatric Urology outlines important topics in the care of elderly urology patients. The first section covers the biology of aging, changes in the genitourinary system, and common diseases including urologic conditions that may serve as warning signs of other disorders. Section two covers geriatric syndromes and implications for urologic care including frailty, polypharmacy, dementia, , and wound healing. Urologic conditions in older adults are explored in detail including urinary incontinence, pelvic organ prolapse, urinary tract infection, nocturia, and benign prostate diseases. Other topics covered include obtaining informed consent, development of advance directives, palliative medicine and care of the dying patient. Geriatric Urology is of great value to urologists, geriatricians, internists, residents and family practitioners.
  • 2015 Springer
    Michael L. Malone, Elizabeth A. Capezuti, Robert M. Palmer, editors.
    Section One: Hospital-based models of care:1. Acute Care for Elders -- 2. Hospital Elder Life Program -- 3. The ACE Consult program -- 4.The Advanced Dementia Consult program -- 5. Acute Care for Elders (ACE) Tracker and "e-Geriatrician" telemedicine program -- 6. The NICHE program to prepare the workforce to address the needs of older patients -- Section Two: Models to address the needs of seniors in transition from hospital to home: 7. Care Transitions Intervention.-8. The Mary Naylor Advanced Practice Nurse model -- 9. Project BOOST -- Section Three: Outpatient-based models of care: 10. The GRACE model. 11. The Guided Care model -- 12. The Stanford Chronic Disease Self-Management program -- 13. Patient Centered Medical Home -- 14. Hospital at Home model -- 15. The Physician Home Visit program.-16. Geriatrics Evaluation and Management (GEM) program -- Section Four: Emergency Department models of care: 17. Geriatrics Emergency Department -- the GEDI WISE program -- Section Five: Models which address the needs of vulnerable populations: 18. The Evercare program to care for vulnerable elders in skilled nursing facilities -- 19. The UCLA Dementia coordinator program -- 20. The Wisconsin Alzheimer's Institute memory assessment program. 21. Memory Care Connections and LEEPS program for early memory assessment -- Section Six: Community related- models of care: 22. Stepping On-falls prevention program -- 23. Program of All-Inclusive Care of Elders (PACE model) -- 24. Wisconsin Family Care social model to support seniors in their homes.
  • 2013 Springer
    Tim Schedl, editor.
    Also available: Print – 2013
  • 2012 Springer Protocols
    edited by Wai-Yee Chan, Le Ann Blomberg.
    Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies -- Neonatal testicular gonocytes isolation and processing for immunocytochemical analysis -- Isolation of undifferentiated and early differentiating type a spermatogonia from pou5f1-GFP reporter mice -- Isolation of human male germ-line stem cells using enzymatic digestion and magnetic-activated cell sorting -- Isolation and purification of murine male germ cells -- Preparation of enriched mouse syncitia-free pachytene spermatocyte cell suspensions -- Revealing the transcriptome landscape of mouse spermatogonial cells by tiling microarray -- Biochemical characterization of a testis-predominant isoform of n-[alpha] acetyltransferase -- Identification of novel long noncoding RNA transcripts in male germ cells -- Methylation profiling using methylated DNA immunoprecipitation and tiling array hybridization -- Spermatogenesis in cryptorchidism -- In vitro culture of fetal ovaries: A model to study factors regulating early follicular development -- Microspread ovarian cell preparations for the analysis of meiotic prophase progression in oocytes with improved recovery by cytospin centrifugation -- In vitro maturation (IVM) of porcine oocytes -- Experimental approaches to the study of human primordial germ cells -- Investigating the origins of somatic cell populations in the perinatal mouse ovaries using genetic lineage tracing and immunohistochemistry -- DNA methylation analysis of germ cells by using bisulfite-based sequencing methods -- Gene expression in mouse oocytes by RNA-Seq.
  • 2008 Springer Protocols
    edited by Steven X. Hou, Shree Ram Singh.
    pt. I. Identification and regulation of germline stem cells in model organisms -- The development of germline stem cells in Drosophila / David A. Dansereau and Paul Lasko -- Analysis of the C. elegans germline stem cell region / Sarah L. Crittenden and Judith Kimble -- Immunohistological techniques for studying the Drosophila male germline stem cell / Shree Ram Singh and Steven X. Hou -- Genetic tools used for cell lineage tracing and gene manipulation in Drosophila germline stem cells / Wei Liu and Steven X. Hou -- Structural polarity and dynamics of male germline stem cells in an insect (milkweed bug Oncopeltus fasciatus) / David C. Dorn and August Dorn -- High-resolution light microscopic characterization of spermatogonia / Hélio Chiarini-Garcia and Marvin L. Meistrich -- Identification and characterization of spermatogonial subtypes and their expansion in whole mounts and tissue sections from primate testes / Jens Ehmcke and Stefan Schlatt -- Epigenetic control in male germ cells : a transillumination-assisted microdissection method for the analysis of developmentally regulated events / Durga Prasad Mishra and Paolo Sassone-Corsi -- GDNF maintains mouse spermatogonial stem cells in vivo and in vitro / Hannu Sariola and Tiina Immonen -- g pt. II. In vitro culture and application of germline stem cells -- Ectopic grafting of mammalian testis tissue into mouse hosts / Ina Dobrinski and Rahul Rathi -- Spermatogonial stem cell transplantation, testicular function, and restoration of male fertility in mice / Derek J. McLean -- Isolating highly pure rat spermatogonial stem cells in culture / F. Kent Hamra ... [et al.] -- Deriving mouse spermatogonial stem cell lines / Ilaria Falciatori ... [et al.] -- Production of knockdown rats by lentiviral transduction of embryos with short hairpin RNA transgenes / Christina Tenenhaus Dann and David L. Garbers -- Testicular germ cell tumors in mice : new ways to study a genetically complex trait / Jason D. Heaney and Joseph H. Nadeau -- Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries / Antonin Bukovsky ... [et al.].
  • 2009 Springer
    Erlene Rosowsky, Joseph M. Casciani, Merla Arnold, editors.
    Policies and Reimbursement: Meeting the Need for Mental Health Care in Long-Term Care / Margaret Norris -- Referrals / Michael Smith -- Assessment / Barry A. Edelstein, Lynn E. Northrop and Lisa M. MacDonald -- Treatment Plans / Deborah W. Frazer -- Treatment Process / Michael Duffy -- Integration of Psychology, Psychiatry, and Medication in Long-Term Care / Lee Hyer and Shalija Shah -- Professional Practice: Disciplines, Documentation, and Outcomes Measurement / Merla Arnold, John C. Colletti and Nicholas C. Stilwell -- Ethical Issues in Long-Term Care / Michele J. Karel.
  • v. 1-2, 1906-11. Google Books
    Neuburger, Max.
  • v. 1, 1940.
    ... von Dozent Dr. Wilhelm Thomsen ... ; mit einem Geleitwort von Prof. Dr. Georg Hohmann ...
    Status: Not Checked OutLane Catalog Record
    I. T. Die Ideen Hermann von Meyer's über die Schuhfrage auf Grund seiner Originalschriften.
  • Insa Eschebach, Astrid Ley (Hrsg.).
  • 2010 Springer
    edited by Catherine Kim, Assiamira Ferrara.
    Hyperglycemia and adverse pregnancy outcome (HAPO) study: an overview -- Evolution of screening and diagnostic criteria for GDM worldwide -- An overview of problems and solutions in the diagnosis and treatment of gestational diabetes -- Prevalence of GDM -- Risk factors for gestational diabetes: from an epidemiological standpoint -- Burden of GDM in developing countries -- Insulin and the placenta in GDM -- What causes gestational diabetes? -- Mechanisms underlying insulin resistance in human pregnancy and gestational diabetes mellitus -- Inflammation, adipokines, and gestational diabetes mellitus -- Lipids in gestational diabetes: abnormalities and significance -- Blood pressure in GDM -- Genetics of gestational diabetes mellitus and type 2 diabetes -- Maternal obesity and epidemiological review of pregnancy complications -- Maternal comorbidities during gestational diabetes mellitus: obstetrical complications, prematurity, and delivery -- The diabetic intrauterine environment: short and long-term consequences -- Exercise recommendations in women with gestational diabetes mellitus -- Nutrition and weight recommendations for treating gestational diabetes mellitus -- Pharmacological treatment options for gestational diabetes -- Risk for maternal postpartum diabetes -- Contraception before and after GDM -- Lactation and diabetes among women with a history of GDM pregnancy -- Emerging science: interventions in women at risk of GDM during pregnancy -- Diabetes prevention interventions for women with a history of GDM -- Diabetes control programs and policy.
  • 2014 CRCnetBASE
    editor, Clive J. Petry.
    "Discussing the origins, care, and consequences of gestational diabetes mellitus (GDM), this book focuses on evidence-based medicine to highlight various aspects of this rapidly growing condition. It provides glucose requirements for fetal growth and maternal and fetal metabolism as well as insulin secretion and sensitivity in pregnancy; covers genetic risk factors, autoimmunity, interaction with obesity, and associations with fetal growth genes; presents diet therapies and the role of exercise and nutrition; and reviews the effects of rapid-, short-, and long-acting insulin, oral hypoglycemic agents in pregnancy, and clinical approaches"--Provided by publisher.
  • Google Books
    Also available: Print – 1899.
  • 2009 ProQuest Safari
    Ford R. Myers.
    The psychology of job hunting in a down market -- From desperation to career strategies for tough times -- Leveraging your core job seeker materials -- Job search tactics to use when no one's hiring -- Bulletproof career, once and for all -- Career resources.
  • 2014 CRCnetBASE
    James Wigley, MBBS BSc MRCS AFHEA, University Hospital Southhampton, Southhampton, UK ; Saran Shantikumar, MRCS BHF Research Fellow, Bristol Heart Institute, Bristol, UK ; Andrew Paul Monk, DPhil MRCS Academic Clinical Lecturer in Orthopaedics, University of Oxford, Oxford, UK.
  • 2012 Wiley
    [edited by] Chris E. Stout.
    Differences in business structures and protections in human service private practice : which suits your practice best? / Jonathan D. Nye -- Making ends meet : financial management in private practice / David W. Ballard -- Managed care contracting : strategies for negotiating and maintaining relationships / Bridget Morehouse -- Ethical and legal aspects of private practice / Scott Hammer and Kenneth H. Kessle.
  • 2007 HighWire
    ed. by Anita Rieder.
  • 2006 Thieme Book
    George W. Eastman, Christoph Wald, Jane Crossin.
  • Rudra Pratap.
    Status: Not Checked OutLane Catalog Record
    Also available: Print – 2007
  • The MathWorks.
  • 2013 ebrary, Limited to 1 simultaneous user
    Sharon Meers and Joanna Strober ; foreword by Sheryl Sandberg.
    Machine generated contents note: Introduction -- Imagine a Full Life -- There's No Need to Choose -- Part One -- The Good News About Work: Why Two Careers Are Better Than One -- 1. Mom and Dada: How Kids Can Get More from Two Working Parents -- 2. What Your Husband Wins from a Working Wife -- 3. What Women Gain from Working Motherhood -- Part Two -- Three Truths to Bust the Myths About Work, Women, and Men -- 4. Women Don't Quit Because They Want To -- 5. Success Does Not Require 24/7 -- 6. It's Not a Fair Game -- but You Can Improve Your Odds -- Part Three -- The 50/50 Solution and How to Make It Yours -- 7. The Great Alliance: How Your Husband Solves the Work/Life Riddle -- 8. The Pre-Baby Road Trip: Mapping Out a Leave You Can Return From -- 9. The Post-Baby Uphill: Test-Driving 50/50 and Getting Back Up to Speed -- 10. Getting to 50/50: At Home, at Work, for Life -- Resources -- Notes -- Acknowledgments -- Index -- About the Authors.
  • Roger Fisher and William Ury.
    Status: Not Checked OutLane Catalog Record
  • 2011 Thieme Book
    edited by Mohit Bhandari, Anders Joensson.
    Why should we publish papers? / George M. Kontakis, Peter V. Giannoudis -- Presented but never published : why research papers are not being published / Cheryl Wylie, Sheila Sprague -- What is the quality of the published orthopaedic literature? / Daniel Vena, Sheila Sprague -- Common pitfalls in the reporting of surgical results / Rudolf W. Poolman -- Overview : what to consider before you start writing / Paul Karanicolas -- Ethics in writing : maintaining credibility / Lyndsay Somerville, Dianne Bryant -- Authorship : what you should know / Rad Zdero, Emil H. Schemitsch -- When do you need a statistician? : more than just number crunchers / Jason W. Busse -- The structured abstract / Ole Brink, Lars C. Borris -- Writing an introduction / Emil H. Schemitsch, Rad Zdero -- Writing a methods section / Emil H. Schemitsch, Rad Zdero -- Results : basics of analysis / Paul Karanicolas -- Results : tables, figures, and appendices / Jacquelyn Marsh, Dianne Bryant -- How to frame a discussion / Kyle Jeray, Stephanie Tanner -- Referencing and acknowledgments / Richard Gould, Bradley Petrisor -- Author instructions / George Mathew, Sheila Sprague -- Formatting your paper : title page and more / Scott Wingerter -- Grammar police : the dos and don'ts of writing / Eric Morrison -- How to address reviewer's comments : dos and don'ts / Rad Zdero, Emil H. Schemitsch -- Getting your research accepted at scientific meetings : writing the abstract / George Mathew, Sheila Sprague -- PowerPoint presentations : tips for presenting your work / Tara M. Mastracci -- Poster presentations : preparing an effective research poster / Chad Coles -- Be consistent : present and publish the same results / Boris A. Zelle.
  • 2009 Springer
    Hadley Wickham.
    Describes ggplot2, a data visualization package for R and a powerful and flexible system for creating data graphics.
  • 2006
    Steven Johnson.
    Status: Not Checked OutLane Catalog Record
    An account of the worst cholera outbreak in Victorian London--and an exploration of how Dr. John Snow's solution revolutionized the way we think about disease in cities. In the summer of 1854, a devastating cholera outbreak seized London just as it was emerging as a modern city: more than 2 million people packed into a ten-mile circumference, a hub of travel and commerce, continually pushing the limits of infrastructure that's outdated as soon as it's updated. Author Johnson chronicles Snow's day-by-day efforts as he risked his own life to prove how the epidemic was being spread. When he created the map that traced the pattern of outbreak back to its source, Dr. Snow didn't just solve a pressing medical riddle--he established a precedent for the way modern city-dwellers, city planners, physicians, and public officials think about the spread of disease and the development of the modern urban environment.--From publisher description.
  • 2012 Springer
    Roy G. Smith, Michael O. Thorner, editors.
    Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
  • 2012 ScienceDirect
    edited by Masayasu Kojima, Kenji Kangawa.
    History to the discovery of ghrelin / Cyril Y. Bowers -- Orphan GPCRs and methods for identifying their ligands / Morikatsu Yoshida, Mikiya Miyazato, and Kenji Kangawa -- Purification of rat and human ghrelins / Masayasu Kojima, Hiroshi Hosoda, and Kenji Kangawa -- Variety of acyl modifications in mammalian ghrelins / Takanori Ida -- Determination of nonmammalian ghrelin / Hiroyuki Kaiya ... [et al.] -- Morphological analysis of ghrelin neurons in the hypothalamus / Haruaki Kageyama, Fumiko Takenoya, and Seiji Shioda -- High-performance liquid chromatography analysis of hypothalamic ghrelin / Takahiro Sato and Masayasu Kojima -- Standard sample collections for blood ghrelin measurements / Hiroshi Hosoda and Kenji Kangawa -- From ghrelin to ghrelin's O-acyl transferase / Jesus A. Gutierrez ... [et al.] -- Enzymatic characterization of GOAT, ghrelin O-acyltransferase / Hideko Ohgusu, Tomoko Takahashi, and Masayasu Kojima -- The study of ghrelin deacylation enzymes / Motoyasu Satou and Hiroyuki Sugimoto -- Synthesis of ghrelin : chemical synthesis and semisynthesis for large-scale preparation of modified peptides / Tomohiro Makino, Masaru Matsumoto, and Yoshiharu Minamitake -- Ghrelin O-acyltransferase assays and inhibition / Martin S. Taylor ... [et al.] -- Model-based evaluation of growth hormone secretion / Johannes D. Veldhuis and Daniel M. Keenan -- Ghrelin in the control of energy, lipid, and glucose metabolism / Kristy M. Heppner ... [et al.] -- Ghrelin and the vagus nerve / Yukari Date -- Measurement of AMP-activated protein kinase activity and expression in response to ghrelin / Chung Thong ... [et al.] -- Ghrelin and gastrointestinal movement / Naoki Fujitsuka ... [et al.] -- Ghrelin acylation by ingestion of medium-chain fatty acids / Yoshihiro Nishi, Hiroharu Mifune, and Masayasu Kojima -- Islet [beta]-cell ghrelin signaling for inhibition of insulin secretion / Katsuya Dezaki and Toshihiko Yada -- Rikkunshito as a ghrelin enhancer / Hiroshi Takeda ... [et al.] -- Thermogenic characterization of ghrelin receptor null mice / Ligen Lin and Yuxiang Sun -- Transgenic mice overexpressing ghrelin or ghrelin analog / Hiroyuki Ariyasu ... [et al.] -- Therapeutic potential of ghrelin in restricting-type anorexia nervosa / Mari Hotta ... [et al.] -- Clinical application of ghrelin for chronic respiratory diseases / Nobuhiro Matsumoto and Masamitsu Nakazato -- Clinical trial of ghrelin synthesis administration for upper GI surgery / Shuji Takiguchi ... [et al.].
  • 2013 Karger
    volume editors, A. Benso, F.F. Casanueva, E. Ghigo, R. Granata.
  • 2016 Springer
    Louis M. Wong kee Song, Emmanuel C. Gorospe, Todd H. Baron, editors.
    Triage Sedation and Monitoring -- Peri-procedural Management of Antithrombotic Agents -- Suspected Non-variceal Upper Gastrointestinal Bleeding -- Approach to Suspected Acute Variceal Bleeding -- Suspected Small Intestinal Hemorrhage -- Suspected Lower Gastrointestinal Bleeding -- Approach to Foreign Body Ingestion, Food Impaction and Caustic Injury -- Non-endoscopic Management of Acute Mechanical Colonic Obstruction and Pseudo-obstruction -- Approach to Acute Cholangitis -- Approach to Endoscopic Adverse Events -- Endoscopic Hemostasis of Acute Non-Variceal Upper Gastrointestinal Bleeding -- Hemostasis of Acute Esophageal Variceal Bleeding -- Hemostasis of Acute Gastric Variceal Bleeding -- Hemostasis of Acute Small Intestinal Bleeding -- Hemostasis of Acute Lower GI Bleeding -- Endoscopic Management of Food Impaction and Foreign Bodies -- Endoscopic Management of Acute Colonic Obstruction and Pseudo-obstruction -- Endoscopic Management of Pancreaticobiliary Emergencies -- Endoscopic Management of Procedure-related Bleeding and Perforation.
  • 2008 Springer
    edited by Gary B. Huffnagle, Mairi Noverr.
    Overview of gut immunology / Katie Lynn Mason ... [et al.] -- The commensal microbiology of the gastrointestinal tract / Janet M. Manson, Marcus Rauch and Michael S. Gilmore -- Overview of the gastrointestinal microbiota / -- Vincent B. Young and Thomas M. Schmidt -- Effects of microbiota on GI health : -- Gnotobiotic research / Robert Doug Wagner -- Positive interactions with the microbiota : probiotics / Marko Kalliomøki, Seppo Salminen and Erika Isolauri -- Negative interactions with the microbiota : IBD / Nita H. Salzman and Charles L. Bevins -- Diet, immunity, and functional foods / Lesley Hoyles and Jelena Vulevic -- Host : microbe communication within the GI tract / Christopher A. Allen and Alfredo G. Torres -- Host : microbe symbiosis : the squid, vibrio association : a naturally occurring, experimental model of animal/bacterial partnerships / Margaret McFall-Ngai -- The "microflora hypothesis" of allergic disease / Andrew Shreiner, Gary B. Huffnagle and Mairi C. Noverr -- The damage : response framework of microbial pathogenesis and infectious diseases / Liise-anne Pirofski and Arturo Casadevall.
    Also available: Print – 2008
  • von Sabine Herrmann.
  • 2011
    Richard S. Gaster.
    Nanotechnology has the unique capability of manipulating and sensing matter at the molecular scale with unprecedented speed, sensitivity, and throughput. The medical application of nanotechnology, nanomedicine, has leveraged nanoscience tools for the advancement of medical diagnostics, therapy, and basic science research. In this work, arrays of magnetically responsive nanosensors, originally developed for use as read heads in computer hard disk drives, have been utilized to achieve in-depth proteomic studies for the advancement of medical diagnostics and therapy. In particular, this dissertation will focus on the following four topics of applying magnetic nanotechnology to science and medicine. First, the application of magnetic nanosensor arrays to early cancer diagnostics and monitoring response to chemotherapy. The utility of magnetic nanosensors as a molecular diagnostics tool capable of profiling a patient's disease state and leveraging a patient's unique molecular signature will be demonstrated. Second, this report will discuss a novel mathematical model expressly developed to describe the kinetic interactions of magnetically labeled biomolecules binding to capture agents immobilized on a surface. Third, a novel autoassembly immunoassay capable of screening for antibody cross-reactivity in a high-density, high-fidelity, and rapid manner will be described. Finally, this report will address the utility of the autoassembly immunoassay in conjunction with a miniaturized magnetic nanosensor platform for point-of-care diagnostics in a cost-effective and easy-to-use (e.g. wash-free) process that can make a significant contribution to global health.
  • 2011 Springer
    Hugo D. Luján, Staffan Svärd, editors.
    1. Taxonomy of Giardia species -- 2. Epidemiology of giardiasis in humans -- 3. Waterborne and environmentally-borne giardiasis -- 4. Giardia in pets and farm animals, and their zoonotic potential -- 5. Genomics of Giardia -- 6. The glycoproteins of Giardia -- 7. Mass spectrometric analysis of phospholipids and fatty acids in Giardia lamblia -- 8. Giardia metabolism -- 9. The ultrastructure of Giardia during growth and differentiation -- 10. Cell cycle regulation and cell division of Giardia -- 11. The Giardia mitosomes -- 12. Signaling pathways in Giardia lamblia -- 13. Transcription and recombination of Giardia -- 14. Intracellular protein trafficking -- 15. Post-transcriptional gene silencing and translation in Giardia -- 16. Antigenic variation of Giardia -- 17. Interaction of Giardia with host cells -- 18. Primary microtubule structures in Giardia -- 19. Pathophysiological processes and clinical manifestations of Giardiasis -- 20. Immunology of giardiasis -- 21. Vaccination against Giardia -- 22. Diagnosis of human giardasis -- 23. Methods for Giardia culture, cryopreservation, encystation, and excystation in vitro -- 24. Synchronization of Giardia -- 25. Methods for Giardia transfection and gene expression -- 26. Biological resource centers for Giardia research.
  • 2010 ebrary, Limited to 1 simultaneous user
    by Brené Brown.
    In this work, the author, a leading expert on shame, authenticity, and belonging, shares ten guideposts on the power of wholehearted living, a way of engaging with the world from a place of worthiness.
  • 2015 ClinicalKey
    [edited by] Peter R. McNally.
    Swallowing disorders and dysphagia -- Gastroesophageal reflux disease -- Esophageal causes of chest pain -- Achalasia -- Esophageal cancer -- Esophageal anomalies, infections, and nonacid injuries -- Barrett's esophagus -- Esophageal and stomach pathology -- Gastritis, peptic ulcer disease, NSAIDs, and Helicobacter pylori infection -- Gastric cancer -- Thickened gastric folds -- Gastroparesis -- Evaluation of abnormal liver tests -- General concepts on viral hepatitis -- Antiviral therapy for hepatitis C -- Antiviral therapy for hepatitis B -- Autoimmune hepatitis : diagnosis -- Autoimmune hepatitis : treatment -- Primary biliary cirrhosis and primary sclerosing cholangitis -- Vaccinations and immunoprophylaxis in gastrointestinal and liver disorders -- Pregnancy and liver disease -- Rheumatologic manifestations of hepatobiliary diseases -- Evaluation of focal liver masses -- Drug-induced liver disease -- Alcoholic liver disease, alcoholism, and alcohol withdrawal syndrome -- Vascular liver disease -- Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis -- Liver transplantation -- Ascites -- Liver abscess -- Inheritable forms of liver disease -- Liver histopathology -- Hepatobiliary cystic disease -- Gallbladder disease : stones, crystals, and sludge -- ERCP plus sphincter of Oddi dysfunction -- Acute pancreatitis -- Chronic pancreatitis -- Pancreatic cancer -- Cystic lesions of the pancreas -- Celiac disease -- Crohn's disease -- Ulcerative colitis -- Eosinophilic gastrointestinal disease and eosinophilic esophagitis -- Small intestinal bacterial overgrowth -- Colon disorders and colon cancer -- Constipation and fecal incontinence -- Diverticulitis -- Diseases of the appendix -- Colitis : pseudomembranous, microscopic, and radiation -- Upper gastrointestinal hemorrhage -- Lower gastrointestinal tract bleeding -- Occult and obscure gastrointestinal bleeding -- Evaluation of acute abdominal pain -- Evaluation of acute infectious diarrhea -- Chronic diarrhea -- Aids and the gastrointestinal tract -- Ischemic bowel disease -- Nutrition, malnutrition, and probiotics -- Small bowel and colon pathology -- Foreign bodies and the gastrointestinal tract -- Functional gastrointestinal disorders and irritable bowel -- Endoscopic cancer screening and surveillance -- Rheumatologic manifestations of gastrointestinal diseases -- Dermatologic manifestations of gastrointestinal disease -- Endocrine aspects of gastrointestinal system -- Plain film, barium, and virtual radiography -- Interventional radiology I : cross-sectional imaging procedures -- Interventional radiology II : fluoroscopic and angiographic procedures -- Noninvasive GI imaging : ultrasound, computed tomography, and magnetic resonance imaging -- Nuclear imaging -- Endoscopic ultrasound -- Advanced therapeutic endoscopy -- Esophageal surgery -- Surgery for peptic ulcer disease -- Surgical approach to the acute abdomen -- Colorectal surgery : polyposis syndromes and inflammatory bowel disease -- Obesity and surgical weight loss -- Minimally invasive surgery -- Clinical vignettes.
  • 2010
    [edited by] Peter R. McNally.
    Status: Not Checked OutLane Catalog Record
  • 2006
    [edited by] Peter R. McNally.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    [edited by] Paul Goetz, Patrick Stoltz, Dominique Delaporte ; préfacé par Alain Drouard.
  • 2010 Springer
    [edited by] Jon E.Grant, Marc N. Potenza ; edizione italiana a cura di Massimo Clerici ; [traduzione a cura di Lara Bellardita].
  • 2008 ebrary
    Eileen Miller ; illustrations by Kim Miller ; foreword by Robert Nickel.
  • 2010 CRCnetBASE
    edited by Ric Skinner.
    Introduction : the evolving role of geographic information systems in hospital and healthcare emergency management / Ric Skinner -- A spatial approach to hazard vulnerability analysis by healthcare facilities / Ric Skinner -- Using GIS to improve workplace and worker safety crisis management / Jeffrey Miller -- Infectious disease surveillance and GIS : applications for emergency management / Michael Olesen -- Role of GIS in interagency healthcare logistical support during emergencies / Jerry VanVactor -- Design concept for a location-based hazard vulnerability assessment tool for healthcare facilities / Ric Skinner -- Trauma center siting, optimization modeling, and GIS / Charles Branas ... [et al.] -- Healthcare facility disaster planning : using GIS to identify alternate care sites / Johnathon Mohr, J.L. Querry, and Gwenn Allen -- Multi-scale enterprise GIS for healthcare preparedness in South Carolina / Jared Shoultz ... [et al.] -- Hospital preparedness planning for evacuation and sheltering with GIS in South Carolina / Jared Shoultz ... [et al.] -- Making sense out of chaos : improving prehospital and disaster response / Elizabeth Walters, Stephen Corbett, and Jeff Grange -- Disaster preparedness for influenza at a community hospital network : a case study / Edward Rafalski ... [et al.] -- Disaster preparedness and response for vulnerable populations : essential role of GIS for emergency medical services during the San Diego County 2007 firestorm / Isabel Corcos... [et al.] -- Natural disasters and the role of GIS in assessing need / Omar Ha-Redeye -- GIS application and a regionalized approach for mass casualty incident planning / Deborah Kim ... [et al.] -- Building a GIS common operating picture for integrated emergency medical services and hospital emergency management response / Frank Zanka.
  • 2011 Springer
    Elisabetta de Lutio di Castelguidone, Antonella Messina, editors ; forewords by Nicholas C. Gourtsoyiannis, Antonio Rotondo, Alfredo Siani.
  • 2008 Springer
    edited by Dieter Birnbacher and Edgar Dahl.
    Should physician-assisted suicide be legalized? / Gerald Dworkin -- Slippery slopes and physician-assisted suicide / Neil Levy -- Physician-assisted suicide and the medical associations / Dieter Birnbacher -- Safe, legal, rare? Physician-assisted suicide and cultural change in the future / Margaret Pabst Battin -- Palliative options of last resort: a comparison of voluntarily stopping eating and drinking, terminal sedation, physician-assisted suicide, and voluntary active euthanasia / Timothy E. Quill, Bernard Lo, Dan W. Brock -- Physician-assisted suicide in Oregon / Linda Ganzini, Edgar Dahl -- Physician-assisted suicide in the Netherlands and Belgium / John Griffiths -- Physician-assisted suicide and the German criminal law / Gabriele Wolfslast -- Physician-assisted death: an Australian perspective / Alan Rothschild -- Assisted dying: the view from the United Kingdom / Sheila A. M. McLean -- Physician-assisted suicide: a doctor's perspective / Pieter Admiraal -- Physician-assisted suicide in Switzerland: a personal report / Elke M. Baezner-Sailer -- The European convention on human rights protects the right of suicide / Ludwig A. Minelli.
  • 2015 Springer
    Rosemary H. Tambouret, David C. Wilbur.
    This volume provides a compact, concise and up-to-date resource for pathologists and clinicians who are involved in women's health. The book summarizes the incidence, epidemiology and risk factors for cervical adenocarcinoma, while reviewing the normal histology of the cervix and glandular lesions of the cervix. The cytological appearance of glandular lesions of the cervix and their mimics is amply illustrated and discussed. Management of glandular lesions is also outlined. Written by authorities in the field, Glandular Lesions of the Uterine Cervix: Cytopathology with Histologic Correlates is of great value to cytopathologists, surgical pathologists, gynecologic oncologists and surgeons.
  • 2006 Ovid
    [edited by] Michèle G. Curtis, Shelley Overholt, Michael P. Hopkins.
    Hirsutism / Steven M. Strong -- Vulvovaginitis / Tracey A. Banks and Michèle G. Curtis -- Sexually transmitted diseases / Lisa M. Hollier -- Chronic pelvic pain / John F. Steege -- Endometriosis / John M. Storment -- Preconception evaluation and counseling / Justin P. Lavin, Jr. and John Stewart, Jr. -- Contraception / Anthony DelConte -- Infertility and recurrent pregnancy loss / John M. Storment -- Surgical and medical abortion / Mitchell D. Creinin -- Urogynecology and pelvic floor dysfunction / Alfred E. Bent -- Lifestyle modification / Jimmy D. Acklin -- Integration of complementary and alternative medicine in the gynecology office / Michèle G. Curtis -- Intimate partner violence / Abbey B. Berenson -- Women and sexuality / Gretchen Gross -- Psychiatric disorders / James M. Martinez and Lauren B. Marangell -- Management of the HIV-positive woman / Nancy L. Eriksen -- Diagnosis and management of hereditary cancer / Monique A. Spillman and Andrew Berchuck -- Occupational and environmental exposures / Linda M. Frazier And David A. Grainger. Pediatric and adolescent gynecology / Andrea L. Zuckerman -- Care of perimenopausal and postmenopausal patients / Clarisa R. Gracia and Kurt T. Barnhart -- Lesbian, bisexual, and transgender health care / Amy E. Harrison and Vincent M. B. Silenzio -- Abnormal cytology and human papillomavirus / Barbara M. Buttin, Thomas J. Herzog, and David G. Mutch -- Benign disorders of the vulva and vagina / Wilson Sawa and Michael P. Hopkins -- Benign disorders and diseases of the breast / Daniel P. Guyton and Andrew Fenton -- Premenstrual syndromes / Meir Steiner -- Abnormal uterine bleeding / Godwin I. Meniru and Michael P. Hopkins --
    Also available: Print – 2006
  • v. 2-3, 2006-09. Springer
    2009 Springer
    editors: Franz Grehn, Robert Stamper.
    Provides a picture of recent progress in the field of glaucoma.
    Also available: Print – 2006-2009
  • 2008 ScienceDirect
    edited by Carlo Nucci, Luciano Cerulli, Neville N. Osborne and Giacinto Bagetta
    1. Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects -- 2. Predictive models to estimate the risk of glaucoma development and progression -- 3. Intraocular pressure and central corneal thickness -- 4. Angle-closure: risk factors, diagnosis and treatment -- 5. Early diagnosis of glaucoma -- 6. Monitoring glaucoma progression -- 7. Standard automated perimetry and algorithms for monitoring glaucoma progression -- 8. Short-wavelength automated perimetry and frequency-doubling technology perimetry in glaucoma -- 9. Scanning laser polarimetry and confocal scanning laser ophthalmoscopy: technical notes on their use in glaucoma -- 10. The role of OCT in glaucoma management -- 11. Functional laser Doppler flowmetry of the optic nerve: physiological aspects and clinical applications -- 12. Advances in neuroimaging of the visual pathways and their use in glaucoma -- 13. Primary open angle glaucoma: an overview of medical therapy -- 14. The treatment of normal-tension glaucoma -- 15. The management of exfoliative glaucoma -- 16. Laser therapies for glaucoma: new frontiers -- 17. Modulation of wound healing during and after glaucoma surgery -- 18. Surgical alternative to trabeculectomy -- 19 Modern aqueous shunt implantation: future challenges -- 20. Model systems for experimental studies: retinal ganglion cells in culture -- 21. Rat models for glaucoma research -- 22. Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection -- 23. Clinical trials in neuroprotection. 24. Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria -- 25. Astrocytes in glaucomatous optic neuropathy -- 26. Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation -- 27. Oxidative stress and glaucoma: injury in the anterior segment of the eye -- 28 TNF-alpha signaling in glaucomatous neurodegeneration -- 29. Involvement of the Bc12 gene family in the signaling and control of retinal ganglion cell death -- 30. Assessment of neuroprotection in the retina with DARC -- 31. Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection -- 32. Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration -- 33. Changes of central visual receptive fields on experimental glaucoma -- 34. Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma -- Stem cells for neuroprotection in glaucoma -- 36. The relationship between neurotrophic factors and CaMKII in the death and survival of retinal ganglion cells -- 37. Evidence of the neuroprotective role of citicoline in glaucoma patients -- 38. Neuroprotection: VEGF, IL-6, and clusterin: the dark side of the moon -- 39. Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection -- 40. 17Beta-estradiol prevents retinal ganglion cell loss induced by the acute rise of intraocular pressure in rat.
  • 2010 Springer
    Paul N. Schacknow, John R. Samples, editors.
    Glaucoma in the twenty-first century -- An evidence-based approach to glaucoma care -- Glaucoma risk factors: intraocular pressure -- Glaucoma risk factors: fluctuations in intraocular pressure -- Glaucoma is a 24/7 disease -- Continuous monitoring of intraocular pressure -- Aqueous veins and open angle glaucoma -- Glaucoma risk factors: the cornea -- Glaucoma risk factors: family history-the genetics of glaucoma -- Glaucoma risk factors: ethnicity and glaucoma.
  • 2016 Springer
    Antonio Ferreras, editor.
    Standard Automated Perimetry -- Gonioscopy -- Measurement of Intraocular Pressure -- Clinical Applications of Ultrasound Biomicroscopy in Glaucoma -- Retrobulbar Ocular Blood Flow Evaluation in Open Angle Glaucoma -- Optic Nerve Head Assessment and Retinal Nerve Fiber Layer Evaluation -- Confocal Scanning Laser Ophthalmoscopy (HRT) -- Detection of Glaucoma Using Scanning Laser Polarimetry -- Optical Coherence Tomography (OCT) -- Measuring Hemoglobin Levels in the Optic Nerve Head for Glaucoma Management -- Structure & Function Relationship in Glaucoma -- Assessment of Structural Glaucoma Progression.
  • 2015 ClinicalKey
    [editors] Tarek M. Shaarawy, Mark B. Sherwood, Roger A. Hitchings, Jonathan G. Crowston.
    As the irreversible effects of glaucoma can lead to blindness, there is high demand for early diagnosis and an ongoing need for practitioners to adopt new and evolving medical and surgical treatment options to improve patient outcomes. Glaucoma, Second Edition is the most comprehensive text and online resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma - aimed at specialists, fellows and general ophthalmologists. More than 300 contributors from six continents provide a truly global perspective and explore new approaches in this user friendly reference which has been updated with enhanced images, more spotlights, new videos, and more.
  • 2008 ClinicalKey
    edited by Teresa C. Chen.
    Trabeculectomy -- Combined cataract and glaucoma surgery -- Bleb revision -- Ahmed valve surgery -- The Krupin eye valve with disk -- Nonvalved single-plate tube shunt procedures: Baerveldt and Molteno implants -- Double-plate Molteno implants -- The 'taco" tube shunt -- Goniotomy -- Trabeculotomy -- Goniosynechialysis -- Surgical peripheral iridectomy -- Anterior chamber washout -- Posterior sclerectomy for choroidal effusion drainage or prophylaxis -- Argon and Nd: YAG peripheral iridotomy -- Argon laser trabeculoplasty -- Selective laser trabeculoplasty -- Argon laser peripheral iridoplasty -- Transscleral diode cyclophotocoagulation -- Endoscopic cyclophotocoagulation.
  • 2012 Karger
    volume editors, Paolo Bettin, Peng Tee Khaw.
    Enhanced trabeculectomy : the Moorfields Safer Surgery System / Khaw, P.T. ... [et al.] -- Deep sclerectomy / Roy, S.; Mermoud, A. -- Glaucoma drainage implant surgery / Aref, A.A.; Gedde, S.J.; Budenz, D.L. -- Postoperative management of penetrating and nonpenetrating external filtering procedures / Bettin, P. -- Ocular surface and external filtration surgery : mutual relationships / Baudouin, C. -- Wound healing and glaucoma surgery : modulating the scarring process with conventional antimetabolites and new molecules / Holló, G. -- Mini-drainage devices : The Ex-PRESS mini-glaucoma device / Rouse, J.M.; Sarkisian Jr, S.R. -- Laser-Assisted Techniques for Penetrating and Nonpenetrating Glaucoma Surgery / Geffen, N.; Assia, E.I. ; Melamed, S. -- Ab externo Schlemm's canal surgery : viscocanalostomy and canaloplasty / Grieshaber, M.C. -- Ab interno Schlemm's canal surgery : trabectome and I-stent / Francis, B.A.; Winarko, J. -- Surgical treatment of angle closure glaucoma / Aquino, M.C. ... [et al.] -- Management of concomitant cataract and glaucoma / Marchini, G.; Ceruti, P.; Vizzari, G. -- Surgical management of pediatric glaucoma / Ou, Y.; Caprioli, J. -- When should we give up filtration surgery : indications, techniques and results of cyclodestruction / Huang, G.; Lin, S.C.
  • 2014 Springer
    Roberto Sampaolesi, Juan Roberto Sampaolesi, Jorge Zarate.
    This second volume in a short series on the glaucomas is devoted to the two main types of the disease, open angle glaucoma and angle closure glaucoma. The contents are based on observations and experience gained during the management of more than 40,000 hospital and 7,000 private patients, with follow-up of 10 to 50 years. The book is comprehensive in scope. All aspects of diagnosis are carefully examined, surgical indications and techniques are explained, and the role of medical treatment is evaluated. Importantly, chapters are included on topics that are frequently overlooked in other books but are important to early diagnosis, such as diurnal pressure curve, HRT, and non-conventional perimetry.
  • 2016 Ovid
    editors, Thomas E. Keane, Sam D. Graham, Jr. ; associate editors, Marc Goldstein [and 7 others].
    Section I. Adrenal, renal, ureter, pelvis / Jerome P. Richie -- section II. Bladder / Stephen J. Savage -- section III. Prostate / Sandip M. Prasad -- section IV. Urethra / Eric S. Rovner -- section V. Testis, epididymis, vas deferens, and seminal vesicles / Marc Goldstein -- section VI. Penis and scrotum / Ramon Virasoro -- section VII. Urinary diversion / Urs E. Studer -- section VIII. Pediatrics / H. Gil Rushton.
  • 2010 Ovid
    editors, Sam D. Graham, Jr., Thomas E. Keane ; consultant editor, James F. Glenn ; associate editors, Charles B. Brendler ... [et al.].
    Anatomy of the adrenal glands, kidney, ureter, and pelvis -- Partial nephrectomy -- Radical nephrectomy -- Intracaval tumors -- Transplant nephrectomy -- Renovascular disease -- Anatrophic nephrolithotomy -- Renal and retroperitoneal abscesses -- Renal trauma -- Renal allotransplantation -- Ureteral complications following renal transplantation -- Renal autotransplantation -- Anatomy of the bladder -- Simple and partial cystectomy -- Radical cystectomy in men -- Radical cystectomy in women -- Bladder diverticulectomy -- Bladder augmentation -- Management of the distal ureter for nephrourecterectomy -- Vesicovaginal fistula -- Enterovesical and rectourethral fistulas -- Vesical trauma and hemorrhage -- Interstitial cystitis/painful bladder syndrome -- Anatomy of the prostate -- Surgery for benign prostatic hypertrophy -- Prostatic imaging and biopsy -- Pelvic lymphadenectomy -- Open radical retropubic prostatectomy -- Radical perineal prostatectomy -- Brachytherapy for localized prostate cancer -- Anatomy of the urethra -- Female urethral diverticulum -- Reconstruction of the female urethra -- Surgical management of the incompetent bladder outlet in the patient with a neurogenic bladder -- Surgery for urethral stricture disease -- Surgery for urethral trauma including urethral disruption -- Carcinoma of the female urethra -- Carcinoma of the male urethra -- Injectable therapies for incontinence in women -- Pubovaginal fascial slings -- Synthetic midurethral retropubic slings -- The transobturator approach to the midurethral sling -- Abdominal retropubic approaches for female incontinence -- The artificial urinary sphincter -- The male sling for postprostatectomy incontinence: current concepts and controversies -- Sacral neuromodulation -- Surgical treatment of pelvic organ prolapse: anatomy of the pelvic floor -- Vaginal hysterectomy for uterine prolapse -- Cystocele and anterior vaginal prolapse -- Transvaginal repair of apical prolapse -- Posterior vaginal prolapse repair -- Abdominal sacral colpopexy -- Anatomy of the epididymis, vas deferens, and seminal vesicle -- Seminal vesicle and ejaculatory duct surgery -- Vasectomy.; Vasoepididymostomy -- Vasovasostomy -- Microsurgical varicocelectomy -- Testis biopsy and testicular sperm extraction (TESE) -- Epididymal sperm aspiration -- Epididymectomy -- Ejaculation induction procedures: penile vibratory stimulation and electroejaculation -- Anatomy of the testis -- Simple orchiectomy -- Inguinal orchiectomy -- Organ-preserving surgery in testicular tumors -- Retroperitoneal lymphadenectomy -- Torsion of the testicle -- Scrotal trauma and reconstruction -- Anatomy of the penis and scrotum -- Partial and total penectomy in the management of invasive squamous cell carcinoma of the penis -- Inguinal lymphadenectomy for penile carcinoma -- Surgical treatment of Peyronie disease -- Priapism -- Penile prosthesis implantation -- Penile venous surgery -- Microvascular arterial bypass surgery for erectile dysfunction -- Penile trauma -- Penile replantation -- Varicocele: general considerations -- Hydrocele and spermatocele -- Congenital curvature -- Reconstruction of the penis for complications of penile enhancement surgery -- Ileal conduit urinary diversion -- Transverse colonic conduit -- Managing the with patient orthotopic bladder substitution -- Orthotopic urinary diversion using in ileal low-pressure reservoir with an afferent tubular segment -- Ileal neobladder -- The Padua ileal bladder -- The T-pouch ileal neobladder -- Colonic orthotopic bladder substitution -- Continent catheterizable reservoir made from ileum -- Continent catheterizable reservoir made from colon -- Ureterosigmoidostomy: Mainz pouch II -- Palliative urinary diversion -- Neuroblastoma -- Wilms tumor -- Renal fusion and ectopia -- Transureteroureterostomy -- Pyeloplasty -- Megaureter -- Prune belly (triad) syndrome -- Childhood rhabdomyosarcoma -- Vesicoureteral reflux -- Endoscopic treatment of vesicoureteral reflux -- Ureteroceles -- Urachal anomalies and related umbilical disorders -- Vesical neck reconstruction -- Surgery for posterior urethral valves -- Hypospadias -- Complete primary repair for exstrophy -- Bladder exstrophy and epispadias -- Congenital anomalies of the scrotum -- Pediatric cryptorchidism, hydroceles, and hernias -- Laparoscopic management of the undescended testicle -- Pediatric laparoscopic pyeloplasty -- Pediatric laparoscopic nephrectomy and partial nephrectomy.; Urogenital sinus and cloacal anomalies -- Surgery to correct ambiguous genitalia (46XX disorder of sexual development) -- Circumcision -- Augmentation cystoplasty in children -- The mitrofanoff procedure in pediatric urinary tract reconstruction -- Basic principles of laparoscopy: transperitoneal, extraperitoneal, and hand-assisted techniques -- Laparoscopic pelvic and retroperitoneal lymph node dissection -- Laparoscopic nephrectomy and partial nephrectomy -- Laparoscopic nephroureterectomy -- Laparoscopic renal procedures: renal cystectomy, biopsy, and nephropexy -- Laparoscopic ablation of small renal masses -- Donor nephrectomy: laparoscopic techniques -- Laparoscopic and robotically assisted pyeloplasty in adults -- Laparoscopic adrenalectomy -- Laparoscopic and robotic radical prostatectomy -- Laparoscopic management of lymphoceles -- Laparoscopic bladder procedures: radical cystectomy, partial cystectomy, urachal excision, diverticulectomy -- Laparoscopic bladder neck suspension -- Miscellaneous laparoscopic urologic procedures: calculus, varicocele, ureterolysis -- Tissue-engineering strategies for urogenital repair -- Image-guided therapy: current practice and future directions -- Robotic surgery -- Energy sources in urology.
    Also available: Print – 2010
  • 2001 ScienceDirect
    edited by B. Castellano López, Manuel Nieto-Sampedro.
    Also available: Print – 2001
  • 2010 Springer
    Swapan K. Ray, editor.
  • 2009 Springer
    Henry deF. Webster, Karl E. Åström.
    Gliogenesis -- Astroglia -- Oligodendroglia -- Microglia -- Ependymal cells -- Tanycytes -- Schwann cells.
  • 2012 Springer
    edited by Ryuya Yamanaka.
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
    Also available: Print – 2012
  • 2013 Springer
    Jolanta Barańska, editor.
    Also available: Print – 2013
  • 2016 ScienceDirect
    edited by Mitchel S. Berger and Michael Weller.
    Ch. 1. Epidemiology -- Ch. 2. Presenting signs and symptoms in brain tumors -- Ch. 3. Neuroimaging -- Ch. 4. Surgical approaches for the gliomas -- Ch. 5. Histologic classification of gliomas -- Ch. 6. Molecular classification of gliomas -- Ch. 7. Next-generation molecular diagnostics -- Ch. 8. Principles of radiation therapy -- Ch. 9. Principles of pharmacotherapy -- Ch. 10. Principles of immunotherapy -- Ch. 11. Experimental therapies: gene therapies and oncolytic viruses -- Ch. 12. Complications of glioma surgery -- Ch. 13. Complications from radiotherapy -- Ch. 14. Complications from pharmacotherapy -- Ch. 15. Vascular complications in glioma patients -- Ch. 16. Epilepsy and brain tumors -- Ch. 17. Rehabilitation of patients with glioma -- Ch. 18. Psycho-oncology -- Ch. 19. Palliative care at the end-of-life in glioma patients -- Ch. 20. Pilocytic astrocytomas -- Ch. 21. Astrocytic gliomas WHO grades II and III -- Ch. 22. Low-grade and anaplastic oligodendroglioma -- Ch. 23. Glioblastoma -- Ch. 24. Rare glial tumors -- Ch. 25. Ependymoma: a heterogeneous tumor of uncertain origin and limited therapeutic options -- Index.
  • 2009 Springer
    Andreas von Deimling (ed.).
    Part I. Gliomas -- Astrocytic tumors / Markus J. Riemenschneider and Guido Reifenberger -- Molecular pathology of oligodendroglial tumors / Christian Hartmann and Andreas von Deimling -- Ependymal tumors / Martin Hasselblatt -- Pediatric gliomas / Stefan Pfister and Olaf Witt -- Hereditary tumor syndromes and gliomas / David Reuss and Andreas von Deimling -- Part II. Management of gliomas -- Surgical management of intracranial gliomas / Matthias Simon and Johannes Schramm -- Radiation therapy / Stephanie E. Combs -- Adjuvant therapy / Wolfgang Wick and Michael Weller -- Other experimental therapies for glioma / Manfred Westphal and Katrin Lamszus -- Neurotoxicity of treatment / Pasquale Calabrese and Uwe Schlegel -- Neuroimaging / R. Klingebiel and G. Bohner -- Part III. Angiogenesis in gliomas / Marcia Machein and Lourdes Sánchez de Miguel -- Gene regulation by methylation / Wolf C. Mueller and Andreas von Deimling -- Brain tumor stem cells / Christian Nern, Daniel Sommerlad, Till Acker and Karl H. Plate.
    Also available: Print – 2009
  • 2007 Springer
    Ken Takasaki.
  • 2007
    Status: Not Checked OutLane Catalog Record
    Acknowledgements -- Introduction: about this Guide -- Part 1. Global ageing and urbanization: meeting the challenge of humanity's success -- Part 2. Active ageing: a framework for age-friendly cities -- Part 3. How the Guide was developed -- Part 4. How to use the Guide -- Part 5. Outdoor spaces and buildings -- Part 6. Transportation -- Part 7. Housing -- Part 8. Social Participation -- Part 9. Respect and social inclusion -- Part 10. Civic participation and employment -- Part 11. Communiciation and information -- Part 12. Community support and health services -- Part 13. Wrapping up and moving forward -- References.
  • 2015
    [by Jane Scobie].
    The Global AgeWatch Index ranks countries according to the social and economic wellbeing of older people.
  • 2007/2008
    Florencia Pauli.
    Status: Not Checked OutLane Catalog Record
  • 2013 WHO
    written by Claudia García-Moreno, Christina Pallitto, Karen Devries, Heidi Stöckl, Charlotte Watts, and Naeemah Abrahams.
    "The report presents the first global systematic review of scientific data on the prevalence of two forms of violence against women: violence by an intimate partner (intimate partner violence) and sexual violence by someone other than a partner (non-partner sexual violence). It shows, for the first time, global and regional estimates of the prevalence of these two forms of violence, using data from around the world. Previous reporting on violence against women has not differentiated between partner and non-partner violence."--Website.
    Also available: Print – 2013
  • 2013 Springer
    Jan Willem van der Laan, Joseph J. DeGeorge, editors.
    The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
  • 2014
    editors, Cezmi A. Akdis, Ioana Agache ; editorial board, Pascal Demoly, Peter Hellings, Antonella Muraro, Nikolaos G. Papadopoulos, Ronald van Ree.
  • 2011 WHO
    editors, Shanthi Mendis, Pekka Puska and Bo Norrving.
    Also available: Print – 2011
  • 2008
    Boerma, J. T.; Fat, Doris Ma; Mathers, Colin D.
    Status: Not Checked OutLane Catalog Record
  • v. 4, 2004 WHO
    Lopez, Alan D.; Murray, Christopher J. L.
  • 2006 NCBI Bookshelf
    Alan D. Lopez ... [et al.], editors.
  • 2012
    Joshua Asher Weinstein.
    The adaptive immune system enables individuals to defend against previously un-encountered pathogens by trial and error. It does so by employing receptors, known as antibodies, whose active genetic diversification fine-tunes this defensive response. Tremendous progress has been made in understanding the mechanisms by which antibodies develop and signal activation. However, it was not until a few years ago, with the advent of affordable in-house high-throughput DNA sequencing, and our publication of whole zebrafish antibody repertoires, that any organism's antibody diversity was characterized comprehensively. In this dissertation, we demonstrate the power of this "top-down" approach to illuminate global, system-wide changes of immune receptor repertoires during organism development and immune response. Special attention is given to applying these measurements to build predictive dynamical models that elucidate the interplay between antibody-sequences and the B-cells that produce them. While we use zebrafish liberally as a model organism for these purposes, cross-species comparisons establish far more general principles of repertoire organization. We go further to evaluate the efficacy of high-throughput immune receptor sequencing to advance clinical goals by inferring which vaccines were received by human patients based on antibody-sequences obtained from whole blood afterward. Finally, we demonstrate the usefulness of single B-cell measurements to correlate antibody mutations to gene expression, thereby providing insight into how these variables co-vary system-wide. This work serves to illustrate the potential of global characterizations of antibody repertoires for providing newer and clearer pictures of immune dynamics in general.
  • 2014 Springer
    Kent E. Pinkerton, William N. Rom, editors.
    Pulmonary physicians and scientists currently have minimal capacity to respond to climate change and its impacts on health. The extent to which climate change influences the prevalence and incidence of respiratory morbidity remains largely undefined. However, evidence is increasing that climate change does drive respiratory disease onset and exacerbation as a result of increased ambient and indoor air pollution, desertification, heat stress, wildfires, and the geographic and temporal spread of pollens, molds and infectious agents. Preliminary research has revealed climate change to have potentially direct and indirect adverse impacts on respiratory health. Published studies have linked climate change to increases in respiratory disease, including the following: changing pollen releases impacting asthma and allergic rhinitis, heat waves causing critical care-related diseases, climate driven air pollution increases, exacerbating asthma and COPD, desertification increasing particulate matter (PM) exposures, and climate related changes in food and water security impacting infectious respiratory disease through malnutrition (pneumonia, upper respiratory infections). High level ozone and ozone exposure has been linked to idiopathic pulmonary fibrosis, lung cancer, and acute lower respiratory infection. Global Climate Change and Public Health is an important new volume based on the research, findings, and discussions of US and international experts on respiratory health and climate change. This volume addresses issues of major importance to respiratory health and fills a major gap in the current literature.
  • 2011 ScienceDirect
    Richard Chin, Menghis Bairu [editors].
  • 2014 ScienceDirect
    edited by Menghis Bairu, Michael Weiner.
  • 2012 ScienceDirect
    edited by Menghis Bairu and Richard Chin.
  • v. 1-3, 1944-54.
    by James Stevens Simmons ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1. pt. 1. India and the Far East. pt. 2. The Pacific area.
  • 2012
    George Dehner.
    Status: Not Checked OutLane Catalog Record
    Know your enemy -- The Murky past of influenza -- Misidentifications and false starts -- The 1920s to the 1980s -- Renewed fears of flu -- Yet another surprise.
  • 2013 Springer
    David V. McQueen, editor.
    Section I. Theoretical and methodological issues -- High-risk versus population prevention strategies for NCDs: Geoffrey Rose revisited in the twenty-first century -- Current and future theoretical foundations for NCDs and health promotion -- The nature of causality: beyond traditional evidence -- Surveillance for NCDs and health promotion: an issue of theory and method -- Section II. Lenses for understanding NCDs -- Learning from the social sciences in chronic diseases health promotion: structure, agency and distributive justice -- Contextual factors in health and illness -- The social determinants of non-communicable diseases: a political perspective -- Risk factors: tobacco -- Physical inactivity and health promotion: evidence and challenges -- NGOs addressing NCDs through a health promotion lens -- Health literacy as a lens for understanding non-communicable diseases and health promotion -- From healthy public policy to intersectoral action and health-in-all policies -- Section III. Approaches to NCDs -- Population health intervention research: a fundamental science for NCD prevention -- Planning and management of cross-sectoral programs: strategies to address NCDs -- The public policy approach: governments, institutions, welfare states and social justice -- Accelerating action on NCDs: Understanding and applying a social determinants of health framework for changes -- Cardiovascular health, risk, and disease: primordial and remedial strategies -- Advocacy strategies to address NCDs: actions to increase the profile of physical activity -- Advocacy strategies to address NCDs: tobacco control -- Evidence synthesis to inform NCD prevention and health promotion -- Using evidence to inform NCD prevention and heal promotion -- The health promotion argument: NCDs and public health -- Public health, NDCs, health promotion, and business partnering: benefits, concerns, remedies, and moving towards creative partnering -- Section IV. Institutions and organizations -- Framing international trade and chronic disease -- Addressing NCDs through multilateral engagement at the United Nations: The role of WHO -- Governance, policy, and institutions -- NCDs and civil society: a history and a roadmap -- Developing health promotion workforce capacity for addressing non-communicable diseases globally -- Health promotion for NCDs in and by hospitals: a health promoting hospital perspective.
  • 2013
    Merrill Singer, Pamela I. Erickson.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Ilona Kickbusch, Graham Lister, Michaela Told, Nick Drager, editors.
    The world's problems are indeed world problems: social and environmental crises, global trade and politics, and major epidemics are making public health a pressing global concern. From this constantly changing scenario, global health diplomacy has evolved, at the intersection of public health, international relations, law, economics, and management--a new discipline with transformative potential. Global Health Diplomacy situates this concept firmly within the human rights dialogue and provides a solid framework for understanding global health issues and their negotiation. This up-to-the-minute guide sets out defining principles and the current agenda of the field, and examines key relationships such as between trade and health diplomacy, and between global health and environmental issues. The processes of global governance are detailed as the UN, WHO, and other multinational actors work to address health inequalities among the world's peoples. And to ensure maximum usefulness, the text includes plentiful examples, discussion questions, reading lists, and a glossary. Featured topics include: The legal basis of global health agreements and negotiations.Global public goods as a foundation for global health diplomacy.Global health: a human security perspective.Health issues and foreign policy at the UN.National strategies for global health.South-south cooperation and other new models of development. A volume of immediate utility with a potent vision for the future, Global Health Diplomacy is an essential text for public health experts and diplomats as well as schools of public health and international affairs.
  • 2014
    Lawrence O. Gostin.
    Global health justice : towards a transformative agenda for health equity -- Globalized health hazards : the need for collective global action -- Global health law in the broader currents of global governance for health -- Fulfilling the promise of the World Health Organization -- Old and new institutions : from the World Bank to the Global Fund, GAVI Alliance, and Gates Foundation -- The international health regulations : responding to public health emergencies of international concern -- The Framework Convention on Tobacco Control : the global response to tobacco -- Health and human rights : human dignity, global justice, and personal security -- Global health, international trade, and intellectual property : toward a fair deal for the global south -- "Getting to zero" : scientific innovation, social mobilization, and human rights in the AIDS pandemic -- The international migration of health workers : a troubling example of global injustice -- Pandemic influenza: a case study on global health security -- The "silent" pandemic of non-communicable diseases -- Imagining global health with justice.
  • 2009
    Status: Not Checked OutLane Catalog Record
  • 2008 ebrary
    edited by Tony Solomonides [and others].
    Advancing virtual communities -- A Healthcare-driven framework for facilitation the secure sharing of data across organizational boundaries -- A Data model for integrating heterogeneous medical data in the Health-e-Child Project -- Gridifying phlogeny and medical applications on the volunteer computing platform -- HOPE, an open platform for medical data management on the grid -- NeuroLOG: a community-driven middleware design -- -- Public health informatics -- How grids are perceived in healthcare and the public service sectior -- From "low hanging" to "user ready": initial steps into a HealthGrid. -- Virtual objects in large scale health information systems -- Toward a virtual anonymisation grid for unified access to remote clinical data -- -- Translational bioinformatics -- A Highly optimized grid deployment: the metagenomic analysis example -- A Grid-based protein complex predictor -- Virtual high throughput screening (vHTS) on an optical high speed testbed -- A Protein structure prediction service in the ProGenGrid system -- BioNessie -- a grid enabled biochemical networks simulation environment -- -- Knowledge management and decision support -- The @neurIST Project -- @neuLink: a service-oriented application for biomedical knowledge discovery -- @neurIST -- chronic disease management through integration of heterogeneous data and computer-interpretable guideline services -- Data privacy considerations in intensive care grids -- Multi-science decision support of HIV drug resistance treatment -- -- Three 'Road maps' -- -- Integrated research team final report HealthGrid: grid technologies for Biomedicine(1-2 March 2006) -- A Roadmap for caGrid, an enterprise grid architecture for biomedical research -- The SHARE road map: healthgrids for biomedical research and healthcare.
  • 2010
    David William Hutton.
    Hepatitis B (HBV) is a vaccine-preventable viral disease that, if untreated, can lead to death from liver disease in 25 percent of patients. Infection with HBV is a major global public health problem, particularly in Asian populations. In an era of limited healthcare budgets, mathematical models can be useful tools to identify cost-effective programs and to support policymakers in making informed decisions. This dissertation describes research on public health policies related to screening, vaccination, and treatment for HBV. It also describe contributions to the theoretical literature on when to stop catch-up vaccination for chronic infectious diseases. In the United States as many as 10% of Asian and Pacific Islander adults are chronically infected with HBV, and up to two thirds are unaware that they are infected. Using Markov models of infection, treatment and disease, I find that screening programs for HBV among Asian and Pacific Islander adults are likely to be cost effective and have clinically significant benefits from identifying chronically infected persons for medical management. Liver disease associated with childhood-acquired HBV is a leading cause of death among adults in China. Approximately 20% of children under age 5 years and 40% of children aged 5 to 19 years remain unprotected from HBV. Using a Markov model of infection and disease progression I find that HBV catch-up vaccination for children and adolescents in China would improve the health of the population and save costs over the long term. Although the 20th century has seen incredible development of safe and effective vaccines, many people remain susceptible to vaccine-preventable diseases. "Catch-up vaccination" for age groups beyond infancy can be an attractive and effective means of immunizing people who were missed earlier. However, as vaccination rates increase, catch-up vaccination may become less attractive. This chapter addresses the question of when to discontinue catch-up vaccination programs as immunization rates increase. I use a cost-effectiveness framework: I consider the cost per quality-adjusted life year gained of catch-up vaccination efforts, as a function of immunization rates over time and consequent disease prevalence and incidence. I illustrate the results with the example of HBV catch-up vaccination in China. I contrast results from a dynamic modeling approach with an approach that ignores the impact of vaccination on disease incidence.
  • 2013
    Deanna Kerrigan, Andrea Wirtz, Stefan Baral, Michele Decker, Laura Murray, Tonia Poteat, Carel Pretorius, Susan Sherman, Mike Sweat, Iris Semini, N'Della N'Jie, Anderson Stanciole, Jenny Butler, Sutayut Osornprasop, Robert Oelrichs, and Chris Beyrer.
    This volume presents an integrated epidemiologic, social, and economic analysis of the global epidemics of HIV among sex workers in low- and middle-income countries. The book provides a comprehensive review and synthesis of the available public health and social science data to characterize the nature, scope, and complexities of these epidemics. A community empowerment-based approach to HIV prevention, treatment, and care is outlined and demonstrated to be cost-effective across multiple settings, with a significant projected impact on HIV incidence among sex workers and transmission dynamics overall. The Global HIV Epidemics among Sex Workers seeks to assist governments, public health implementing agencies, donors, and sex worker communities to better understand and respond to the epidemics among a population facing heightened social and structural vulnerabilities to HIV. The book combines a systematic review of the global epidemiology of HIV among sex workers and in-depth case studies of the epidemiology, policy and programmatic responses and surrounding social contexts for HIV prevention, care and treatment in eight countries. The authors employ mathematical modeling and cost-effectiveness analysis to assess the potential country-level impact of a community empowerment-based approach to HIV prevention, treatment, and care among sex workers when taken to scale in four countries representing diverse sociopolitical contexts and HIV epidemics: Brazil, Kenya, Thailand, and Ukraine. In each setting, greater investment in prevention, treatment, and care for sex workers is shown to significantly reduce HIV. Together these findings underline the urgency of further global investment in comprehensive, human rights-based responses to HIV among sex workers.
  • 2013
    Martin Prince, Maëlenn Guerchet, and Matthew Prina.
    Although high income countries, including the G8, have borne the brunt of the dementia epidemic, this is a global phenomenon. Most people with dementia live in low and middle income countries, and most of the dramatic increases in numbers affected, through to 2050, will occur in those regions. In a spirit of international cooperation and solidarity we urge the G8 governments to sponsor intergovernmental action to make dementia a global priority. Crucially, this must include opening up access to diagnosis and current evidence-based treatment and care. All countries worldwide are failing in this basic objective. Action to address this problem should be balanced, as a priority, with research to improve treatment options and quality of care.
  • 2008 Springer
    Bradly J. Condon, Tapen Sinha.
  • The Global Library of Women's Medicine is a unique web library incorporating a vast range of detailed clinical information across women's medicine. It consists of 442 main chapters and 53 supplementary chapters, supported by over 40,000 references, which will be kept permanently up-to-date. The chapters have been written by more than 650 specialists and will reflect some of the very best worldwide opinion.
  • 2013
    T. Randolph Beard, David L. Kaserman, and Rigmar Osterkamp ; with a foreword by Friedrich Breyer.
    The evolution of organ transplantation and procurement policy -- Consequences of the current policy -- Social costs and benefits of transplants -- Economic and political causes of the shortage of organs -- Reforms short of open donor compensation -- An assessment of the moral basis of alternative organ donation rules -- Compensation for organ donation and a proposal for a public monopsony for organ acquisition.
  • 2014 Springer
    R. Gosselin, D. Spiegel, M. Foltz (eds.).
    Global Orthopedics: Caring for Musculoskeletal Conditions and Injuries in Austere Settings was conceived and written to be a unique reference for surgeons working in resource-limited environments. The first sections provide historical background, global public health perspectives of orthopedics, the role of culture, and a broad discussion of non-surgical and non-orthopedic clinical topics that are rarely encountered in high-resource settings but that affect orthopedic care. Adult and pediatric trauma are presented in an anatomical format for easy reference, with a focus on the natural history and the best treatment methods within existing limitations. The chapters on musculoskeletal infections provide a wealth of knowledge about these common debilitating conditions that is unavailable in any other single modern text. The non-infectious pediatric conditions section has been written for the non-specialist to handle selected developmental and early childhood orthopedic problems commonly seen in low-resource settings. Detailed chapters on reconstruction surgery, tumor management, amputations, and the orthopedic needs in the face of conflicts and natural disasters round out the text.
  • 2011 ScienceDirect
    edited by Debasis Bagchi.
    Chapter 1. Pediatric Obesity: A Pediatrician's Viewpoint / Allison Collins, Rebecka Peebles -- Chapter 2. Salient Features on Child Obesity from the Viewpoint of a Nutritionist / Bernard Waysfeld, Dominique Adele Cassuto -- Chapter 3. Developmental Trajectories of Weight Status in Childhood and Adolescence / Samar Hejazi, V. Susan Dahinten, Pamela A. Ratner, Sheila K. Marshall -- Chapter 4. The Measurement and Epidemiology of Child Obesity / David S. Freedman, Cynthia L. Ogden, Sarah E. Cusick -- Chapter 5. Good-Enough Parenting, Self-Regulation, and the Management of Weight-Related Problems / Moria Golan -- Chapter 6. Nursing Perspective on Childhood Obesity / Cynthia Yensel, Carrie Tolman -- Chapter 7. Contemporary Racial/Ethnic and Socioeconomic Patterns in U.S. Childhood Obesity / Gopal K. Singh, Michael D. Kogan -- Chapter 8. Prediabetes among Obese Youth / Orit Pinhas-Hamiel, Phil Zeitler -- Chapter 9. Prediabetes and Type 2 Diabetes: An Emerging Epidemic among Obese Youth / Kathryn Love-Osborne -- Chapter 10. Prevalence of the Metabolic Syndrome in U.S. Youth / Sarah E. Messiah, Kristopher L. Arheart, Steven E. Lipshultz, Tracie L. Miller -- Chapter 11. Emerging Pathways to Child Obesity Starts from the Mother's Womb: A Prospective View / Ashik Mosaddik -- Chapter 12. The Social, Cultural and Familial Contexts Contributing to Childhood Obesity / Cathy Banwell, Helen Kinmonth, Jane Dixon -- Chapter 13. Cardiovascular Risk Clustering in Obese Children / Ram Weiss -- Chapter 14. A Link between Maternal and Childhood Obesity / Siân Robinson -- Chapter 15. Is Prenatal Exposure to Maternal Obesity Linked to Child Mental Health? / Alina Rodriguez -- Chapter 16. Sleep and Obesity in Children and Adolescents / Amy Darukhanavala, Silvana Pannain -- Chapter 17. Cellular Remodeling during the Growth of the Adipose Tissue / Coralie Sengenès, Virginie Bourlier, Jean Galitzky, Alexia Zakaroff-Girard, Max Lafontan, Anne Bouloumié -- Chapter 18. Children Obesity, Glucose Tolerance, Ghrelin, and Prader-Willi Syndrome / Simonetta Bellone, Arianna Busti, Sara Belcastro, Gianluca Aimaretti, Gianni Bona, Flavia Prodam -- Chapter 19. Insulin Resistance and Glucose Metabolism in Childhood Obesity / Subhashini Yaturu, Sushil K. Jain -- Chapter 20. Insulin Resistance in Pediatric Obesity: Physiological Effects and Possible Diet Treatment / Ulf Holmbäck -- Chapter 21. Role of Fatty Liver Disease in Childhood Obesity / Valerio Nobili, Anna Alisi, Melania Manco -- Chapter 22. An Overview of Psychosocial Symptoms in Obese Children / Lisa Y. Gibson -- Chapter 23. Childhood Obesity: Depression, Anxiety and Recommended Therapeutic Strategies / Dana L. Rofey, Jessica J. Black, Jennifer E. Phillips, Ronette Blake, KayLoni Olson -- Chapter 24. The Emotional Impact of Obesity on Children / Robert E. Cornette -- Chapter 25. Psychiatric Illness, Psychotropic Medication, and Childhood Obesity / Lawrence Maayan, Leslie Citrome -- Chapter 26. Childhood Obesity: Public Health Impact and Policy Responses / Rogan Kersh, Brian Elbel -- Chapter 27. Childhood Obesity and Juvenile Diabetes / Mikael Knip -- Chapter 28. Bone Health in Obesity and the Cross Talk between Fat and Bone / Sowmya Krishnan, Venkataraman Kalyanaraman -- Chapter 29. A Community-Level Perspective for Childhood Obesity Prevention / Christina Economos, Erin Hennessy -- Chapter 30. School-Based Obesity-Prevention Programs / Genevieve Fridlund Dunton, Casey P. Durand, Nathaniel R. Riggs, Mary Ann Pentz -- Chapter 31. School-Based Obesity Prevention Interventions Show Promising Improvements in the Health and Academic Achievements among Ethnically Diverse Young Children / Danielle Hollar, Sarah E. Messiah, Gabriela Lopez-Mitnik, T. Lucas Hollar, Michelle Lombardo -- Chapter 32. School and Community-Based Physical Education and Healthy Active Living Programs: Holistic Practices in Hong Kong, Singapore, and the United States / Ming-Kai Chin, Christopher R. Edginton, Mei-Sin Tang, Kia-Wang Phua, Jing-Zhen Yang -- Chapter 33. Schools as “Laboratories” for Obesity Prevention: Proven Effective Models / Michelle Lombardo, Danielle Hollar, T. Lucas Hollar, Karen McNamara -- Chapter 34. Fitness and Fatness in Childhood Obesity: Implications for Physical Activity / Sarah P. Shultz, Benedicte Deforche, Nuala M. Byrne, Andrew P. Hills -- Chapter 35. Pharmacotherapy in Childhood Obesity / Amélio F. Godoy-Matos, Erika Paniago Guedes, Luciana Lopes de Souza, Mariana Farage -- Chapter 36. Beverage Interventions to Prevent Child Obesity / Rebecca Muckelbauer, Mathilde Kersting, Jacqueline Müller-Nordhorn -- Chapter 37. Psychotherapy as an Intervention for Child Obesity / Carl-Erik Flodmark -- Chapter 38. Childhood Obesity: Psychological Correlates and Recommended Therapeutic Strategies / Jennifer E. Phillips, Ethan E. Hull, Dana L. Rofey -- Chapter 39. Dietary Supplements in the Prevention and Treatment of Childhood Obesity / Robert I-San Lin -- Chapter 40. The Role of Arginine for Treating Obese Youth / Catherine J. McNeal, Guoyao Wu, Susie Vasquez, Don P. Wilson, M. Carey Satterfield, Jason R. McKnight, Hussain S. Malbari, Mujtaba Rahman -- Chapter 41. Prevention of Childhood Obesity with Use of Natural Products / Jin-Taek Hwang, Dae Young Kwon, Joohun Ha -- Chapter 42. The Role of United States Law to Prevent and Control Childhood Obesity / Jennifer L. Pomeranz -- Chapter 43. Childhood Obesity as an Amplifier of Societal Inequality in the United States / Stanley J. Ulijaszek -- Chapter 44. Childhood Obesity, Food Choice and Market Influence / Jane Kolodinsky, Amanda Goldstein, Erin Roche -- Chapter 45. The Role of Media in Childhood Obesity / Amy B. Jordan, Ariel Chernin -- Chapter 46. Evaluation and Management of Childhood Obesity in Primary Care Settings / Goutham Rao -- Chapter 47. The Future Directions and Clinical Management of Childhood Obesity / Clodagh S. O'Gorman, Jonathan Cauchi, Jill K. Hamilton, Denis Daneman.
  • 2007 Springer
    edited by David V. McQueen and Catherine M. Jones.
    Global perspectives on health promotion and effectiveness: an introduction / David V. McQueen and Catherine M. Jones -- The Global Programme on Health Promotion Effectiveness (GPHPE): a global process for assessing health promotion effectiveness with regional diversity / Catherine M. Jones ... [et al.] -- The IUHPE blueprint for direct and sustained dialogue in partnership initiatives / Catherine M. Jones and Maurice B. Mittelmark -- The Global Programme on Health Promotion Effectiveness: a case study of global partnership functioning / J. Hope Corbin and Maurice B. Mittelmark -- Policies for health: the effectiveness of their development, adoption, and implementation / Evelyne de Leeuw -- Strengthening the evidence base for mental health promotion / Margaret M. Barry ... [et al.] -- Effectiveness and challenges for promoting physical activity globally / Trevor Shilton ... [et al.] -- School health promotion: achievements, challenges, and priorities / Lawrence St. Leger ... [et al.] -- Health promotion to prevent obesity: evidence and policy needs / Tim Lobstein and Boyd Swinburn -- Effective health promotion against tobacco use / Karen Slama ... [et al.] -- Effectiveness of health promotion in preventing alcohol related harm / Peter Howat ... [et al.] -- Globalization and health promotion: the evidence challenge / Ronald Labonte -- Urbanization and health promotion: challenges and opportunities / Andrea Neiman and Mary Hall -- Community interventions on social determinants of health: focusing the evidence / Marilyn Metzler ... [et al.] -- Strengthening peace-building through health promotion: development of a framework / Anne W. Bunde-Birouste and Jan E. Ritchie -- The role of governance in health promotion effectiveness / Marilyn Wise -- Evidence and theory: continuing debates on evidence and effectiveness / David V. McQueen -- Measurement and effectiveness: methodological considerations, issues, and possible solutions / Stefano Campostrini -- Healthy settings: building evidence for the effectiveness of whole system health promotion--challenges and future directions / Mark Dooris ... [et al.] -- Feasibility for health promotion under various decision-making contexts / Ligia de Salazar -- Evaluating equity in health promotion / Louise Potvin, Pascale Mantoura, and Valéry Ridde -- Evaluation of empowerment and effectiveness: universal concepts? / Valéry Ridde, Treena Delormier, and Ghislaine Goudreau -- Enhancing the effectiveness and quality of health promotion: perspectives of the International Union for Health Promotion and Education / Maurice B. Mittelmark ... [et al.] -- Annex: Global Programme on Health Promotion Effectiveness: description and list of partners.
  • 2013 Springer
    Ichiro Kawachi, Soshi Takao, S.V. Subramanian, editors.
    The idea of social capital emerged in the social science disciplines to explain puzzling phenomena such as why some communities fare better in crisis than others. As the field matures, it has been adapted to wide-ranging issues such as population health. This book presents the major research issues as well as nuanced theoretical discussion in keeping with an evolving field in Europe, Asia, and the U.S. Background chapters analyze how social capital manifests in neighborhoods, workplaces, and schools, and its relationship to health. The second half offers guidelines for improving population health at the social capital level, and examples of interventions, such as microfinance programs, in which enhanced social capital and health benefits are a significant by-product. And a number of contributors debate the problems of defining the concept and using the term at all.
  • 2012 WHO
    Navigating the GPIRM -- Acronyms and abbreviations -- Contributors -- Foreword -- Executive summary -- Part 1. The threat of insecticide resistance -- 1.1 Malaria vector control today -- 1.2 Status of insecticide resistance -- 1.3 Potential effect of resistance on the burden of malaria -- 1.4 Available strategies for managing resistance -- Part 2. Collective strategy against insecticide resistance -- 2.1 Overall malaria community strategy -- 2.2 Country activities -- 2.3 Research agenda -- 2.4 enabling mechanisms -- 2.5 Financial cost -- Part 3. Technical recommendations for countries -- 3.1 Geographical areas with unknown levels of resistance -- 3.2 Geographical areas in which indoor residual spraying is the main form of vector control -- 3.3 Geographical areas in which LLINs are the main form of vector control -- 3.4 Geographical areas in which LLINs and IRs are already used in combination -- 3.5 Choosing alternative insecticides -- Part 4. Near-term action plan -- 4.1 Role of each stakeholder group -- 4.2 Action plan -- References -- Annex 1 Past use of malaria vector control tools -- Annex 2 Long-lasting insecticidal nets, indoor residual spraying and other vector control interventions -- Annex 3 History of insecticide resistance in malaria vectors -- Annex 4 Challenges in measuring the impact of insecticide resistance on the effectiveness of vector control -- Annex 5 example of 'tipping-point' in resistant Aedes mosquitoes -- Annex 6 selection pressure: role of public health, agriculture and other factors -- Annex 7 Implications of discriminating doses of insecticide on detection of resistance -- Annex 8 Main hypotheses used to model the impact of insecticide resistance on malaria burden -- Annex 9 use of insecticide resistance management strategies (rotations, combinations, mosaics and mixtures) -- Annex 10 Genetic research agenda -- Annex 11 Financial modelling -- Annex 12 Definitions.
    Also available: Print – 2012
  • 2012 WHO
    Also available: Print – 2012
  • 2016 WHO
    World Health Organanization.
    Preface -- Acknowledgements -- Executive summary -- Background -- Part 1. Global burden of diabetes -- 1.1. Mortality from high blood glucose, including diabetes -- 1.2. Prevalence of diabetes and associated risk factors -- 1.3 Burden and trends in the complications of diabetes -- 1.4. Summary -- Part 2. Preventing diabetes -- 2.1. Population-based prevention -- 2.2. Preventing diabetes in people at high risk -- 2.3. Summary -- Part 3. Managing diabetes -- 3.1. Diagnosis and early detection -- 3.2. Management of diabetes--core components -- 3.3. Integrated management of diabetes and other chronic health conditions -- 3.4. Access to essential medicines and basic technologies -- 3.5. Summary -- Part 4. National capacity for prevention and control of diabetes: a snapshot -- 4.1. National policies and plans for diabetes -- 4.2. National guidelines and protocols -- 4.3. Availability of essential medicines and technologies -- 4.4. Surveillance and monitoring -- 4.5. Summary -- Conclusions and recommendations -- Annexes -- Annex A. Current WHO recommendations for the diagnostic criteria for diabetes and intermediate hyperglycaemia -- Annex B. Methods for estimating diabetes prevalence, overweight and obesity.
    Also available: Print – 2016
  • 2014 WHO
    The WHO Global report on drowning: preventing a leading killer highlights that 372,000 people drown worldwide each year. Drowning is among the ten leading causes of death for children and young people in every region of the world. The report sets out the evidence showing a range of effective drowning prevention strategies, and makes a number of recommendations for concrete measures to be taken by national and local governments. With the release of this report, WHO aims to galvanize attention and action to this issue by highlighting how collaboration across sectors can save lives.--Publisher description.
    Also available: Print – 2014
  • [Laura Thomas].
    Key Terms in Palliative Care and Pain Treatment -- Summary -- I. Background: Palliative Care and Pain Treatment -- The Need for Palliative Care and Pain Treatment -- The Consequences of Untreated Pain and Lack of Palliative Care -- Impact of Palliative Care and Pain Management -- The Palliative Care and Pain Treatment Gap -- Barriers to Palliative Care and Pain Treatment -- II. Survey Findings: Global Overview of Barriers to Pain Treatment -- Availability of Policies that Promote Palliative Care and Pain Treatment -- Training for Healthcare Workers -- Drug Availability -- Supply and Distribution System for Opioid Analgesics -- Drug Regulations -- Cost of Opioid Medications -- Best Practices: Addressing Barriers to Pain Treatment and Palliative Care through Comprehensive Reform -- Africa Map -- III. Sub-Saharan Africa -- Regional Overview -- Drug Availability -- Drug Regulations -- Best Practice and Reform Efforts: Uganda -- The Americas Map -- IV. The Americas -- Regional Overview -- Drug Availability -- Best Practice and Reform Efforts: Colombia -- The Middle East and North Africa Map -- V. The Middle East and North Africa -- Regional Overview -- Drug Availability -- Developing Palliative Care: Jordan -- Europe Map -- VI. Europe -- Regional Overview -- Drug Availability -- Best Practice and Reform Efforts: Romania -- Asia Map -- VII. Asia -- Regional Overview -- Drug Availability -- Developing Palliative Care: Vietnam -- VIII. International Human Rights Obligations and Pain Treatment -- Health as a Human Right -- Pain Treatment and the Right to the Highest Attainable Standard of Health -- Pain Treatment and the Right to Be Free from Cruel, Inhuman, and Degrading Treatment -- IX. Recommendations -- To Governments around the World -- General -- Ensuring an Effective Supply System -- Developing and Enacting Pain Management and Palliative Care Policies -- Ensuring Instruction for Healthcare Workers -- Reforming Drug Regulations -- Ensuring Affordability of Medications -- To Global Drug Policy Makers -- To the WHA, WHO, UNAIDS, and the Donor Community -- To the Global Human Rights Community -- X. Methodology -- Acknowledgements -- Appendix 1. List of Survey Participants -- Appendix 2. Survey Questions -- Appendix 3. Table of Calculations Used to Produce Maps.
  • 2011 WHO
    "This publication presents a comprehensive perspective on the worldwide, regional and country consumption of alcohol, patterns of drinking, health consequences and policy responses in member states. It represents a continuing effort by WHO to support member states with global information in their efforts to reduce the harmful use of alcohol and its health and social consequences"--Publisher's description.
    Also available: Print – 2011
  • 2014 WHO
    The Global status report on alcohol and health 2014 presents a comprehensive perspective on the global, regional and country consumption of alcohol, patterns of drinking, health consequences and policy responses in Member States. It represents a continuing effort by the World Health Organization (WHO) to support Member States in collecting information in order to assist them in their efforts to reduce the harmful use of alcohol, and its health and social consequences. The report was launched in Geneva on Monday 12 May 2014 during the second meeting of the global network of WHO national counterparts for implementation of the global strategy to reduce the harmful use of alcohol.--Publisher's description.
    Also available: Print – 2014
  • 2014 WHO
    This global status report on prevention and control of NCDs (2014), is framed around the nine voluntary global targets. The report provides data on the current situation, identifying bottlenecks as well as opportunities and priority actions for attaining the targets. The 2010 baseline estimates on NCD mortality and risk factors are provided so that countries can report on progress, starting in 2015. In addition, the report also provides the latest available estimates on NCD mortality (2012) and risk factors, 2010-2012. All ministries of health need to set national NCD targets and lead the development and implementation of policies and interventions to attain them. There is no single pathway to attain NCD targets that fits all countries, as they are at different points in their progress in the prevention and control of NCDs and at different levels of socioeconomic development. However all countries can benefit from the comprehensive response to attaining the voluntary global targets presented in this report.--Publisher description.
    Also available: Print – 2014
  • 2011 WHO
    "This report sets out the statistics, evidence and experiences needed to launch a more forceful response to the growing threat posed by noncommunicable diseases. While advice and recommendations are universally relevant, the report gives particular attention to conditions in low- and middle-income countries, which now bear nearly 80% of the burden from diseases like cardiovascular disease, diabetes, cancer and chronic respiratory diseases. The health consequences of the worldwide epidemic of obesity are also addressed. The report takes an analytical approach, using global, regional and country-specific data to document the magnitude of the problem, project future trends, and assess the factors contributing to these trends. As noted, the epidemic of these diseases is being driven by forces now touching every region of the world: demographic aging, rapid unplanned urbanization, and the globalization of unhealthy lifestyles"--Publisher's description.
    Also available: Print – 2011
  • 2015 WHO
    Also available: Print – 2015
  • 2013 WHO
    This report provides legislation data last updated in 2011 and fatality data updated for 2010.
    Also available: Print – 2013
  • 2009 WHO
    Department of Violence & Injury Prevention & Disability, World Health Organization.
    "Over 1.2 million people die each year on the world' roads, and between 20 and 50 million suffer non-fatal injuries. In most regions of the world this epidemic of road traffic injuries is still increasing. In the past five years most countries have endorsed the recommendations of the World report on road traffic injury prevention which give guidance on how countries can implement a comprehensive approach to improving road safety and reducing the death toll on their roads. To date, however, there has been no global assessment of road safety that indicates the extent to which this approach is being implemented. This Global status report on road safety is the first broad assessment of the status of road safety in 178 countries, using data drawn from a standardized survey conducted in 2008. The results provide a benchmark that countries can use to assess their road safety position relative to other countries, while internationally the data presented can collectively be considered as a global "aseline"against which progress over time can be measured. " - p. [v11]
    Also available: Print – 2009
  • 2014 WHO
    World Health Organization ; UNODC, United Nations Office on Drugs and Crime ; UNDP, United Nations Development Programme ; [Alexander Butchart and Christopher Mikton coordinated and wrote the report].
    The Global status report on violence prevention 2014, which reflects data from 133 countries, is the first report of its kind to assess national efforts to address interpersonal violence, namely child maltreatment, youth violence, intimate partner and sexual violence, and elder abuse. Jointly published by WHO, the United Nations Development Programme, and the United Nations Office on Drugs and Crime, the report reviews the current status of violence prevention efforts in countries, and calls for a scaling up of violence prevention programmes; stronger legislation and enforcement of laws relevant for violence prevention; and enhanced services for victims of violence.--Publisher description
    Also available: Print – 2014
  • 2010 WHO
    The global strategy to reduce the harmful use of alcohol. Setting the scene -- Challenges and opportunities -- Aims and opportunities -- Guiding principles -- National policies and measures -- Policy options and interventions -- Global action : key roles and components -- Implementing the strategy -- Resolution of the sixty-third World Health Assembly (May 2010) WHA63.13 Global Strategy to Reduce the Harmful Use of Alcohol.
    Also available: Print – 2010
  • 2015 ebrary, Limited to 3 simultaneous users
    edited by John G. Meara, Craig D. McClain, David P. Mooney, Selwyn O. Rogers, Jr.
  • 2007
    Bousquet, Jean; Khaltaev, Nikolai.
    Status: Not Checked OutLane Catalog Record
  • 2014 WHO
    World Health Organization.
    "This is the nineteenth global report on tuberculosis (TB) published by WHO in a series that started in 1997. It provides a comprehensive and up-to-date assessment of the TB epidemic and progress in implementing and financing TB prevention care and control at global regional and country levels using data reported by over 200 countries that account for over 99% of the world's TB cases. The report is accompanied by a special supplement that marks the 20th anniversary of the establishment of the Global Project on Anti-TB Drug Resistance Surveillance. The supplement highlights the latest status of knowledge about the epidemic of multidrug-resistant TB (MDR-TB) and the programmatic response."--Ebook Library.
    Also available: Print – 2014
  • 2013 WHO
    World Health Organization.
    ch. 1. Introduction -- ch. 2. The burden of disease caused by TB -- ch. 3. TB case notifications and treatment outcomes -- ch. 4. Drug-resistant TB -- ch. 5. Diagnostics and laboratory strengthening -- ch. 6. Addressing the co-epidemics of TB and HIV -- ch. 7. Financing -- ch. 8. Research and development.
    Also available: Print – 2013
  • 2015 WHO
    Also available: Print – 2015
  • 2012 WHO
    World Health Organization.
    "The World Health Organization (WHO) Global Tuberculosis Report 2012 provides the latest information and analysis about the tuberculosis (TB) epidemic and progress in TB care and control at global, regional and country levels. It is based primarily on data reported by WHO's Member States in annual rounds of global TB data collection. In 2012, 182 Member States and a total of 204 countries and territories that collectively have more than 99% of the world's TB cases reported data." --Executive summary, p. 1.
    Also available: Print – 2012
  • 2006 Springer
    edited by Belinda Bennett and George F. Tomossy.
  • 2013
    edited by I. Glenn Cohen.
    "Gives an integrated approach to interdisciplinary problems that spans fields including law and medicine. -- Medical tourism and telemedicine are growing rapidly in the last decade and this book helps readers to understand the implications of this development. -- Aids readers in understanding the impact of Obamacare on the globalization of health care." -- [Publisher-supplied data]
  • 2014 Springer
    Mirto Foletto, Raul J. Rosenthal, editors ; foreword by Nicola Scopinaro.
    The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with growing demand. This book aims to provide guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Epidemiology, organizational and logistical aspects, nursing issues, patient assessment, anesthesiology, and surgical practicalities are expertly covered in the opening chapters. Techniques of relevance to the general surgeon are described according to anatomic region, covering the head and neck; cardiothoracic and vascular system; upper and lower GI tract; pancreas, liver and adrenal glands; urinary tract and kidneys; the reproductive system; and the abdominal wall. Results achieved by bariatric surgery worldwide are reviewed, and the book closes with a chapter devoted to plastic and reconstructive surgery. The Globesity Challenge to General Surgery highlights a need for global rethinking on public health as regards resource allocation and patterns and standards of care, improving outcomes through greater affordability.
  • pt. A-B, 2008. ScienceDirect
    pt. B, 2008 ScienceDirect
    edited by Robert K. Poole.
    Also available: Print – pt. A-B, 2008.
  • David M. Glick.
  • 2006 CRCnetBASE
    Kimball Nill.
  • 2002 CRCnetBASE
    Kimball Nill.
  • 2015 Springer
    Jen-Chywan Wang, Charles Harris, editors.
    This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
    Also available: Print – 2015
  • 2011
    Shawn Fletcher Sorrells.
    Glucocorticoids (GCs) are stress hormones that are well-known for their potent and pleiotropic anti-inflammatory effects. In the injured CNS, their anti-inflammatory properties could be particularly beneficial due to the often detrimental effects of excessive inflammation in the brain. In more recent years, however, it has become clear that GCs do not always decrease inflammation and can even augment aspects of the immune response. The research presented in this doctoral dissertation describes the impact of this increased inflammatory response in the CNS using animal models of excitotoxicity and hypoxia/ischemia. Specifically, both exogenous GC treatments and the endogenously released GCs post-injury were found to increase immune cell activation (both in phenotype and in p65 nuclear translocation) in both rat and mouse models of excitotoxic hippocampal neuron death and in a mouse MCAO stroke model. These increased inflammatory responses are likely to be mediated by an unexpected GC-suppression of several anti-inflammatory cytokines including CX3CL1 and CD22 and failure of GCs to activate some of their normal anti-inflammatory targets like IkBa, IL-1ra, and MKP-1. Furthermore, these GC-augmented inflammatory responses are necessary for GCs to make more neurons die from either of these injuries. Taken together, this work demonstrates that cellular inflammation is not kept in check by GCs in the forebrain; instead, GCs worsen hippocampal and cortical neuron death, at least in part, by increasing the neurotoxicity of CNS inflammation.
  • 2014 Springer
    Vladimir Parpura, Arne Schousboe, Alexei Verkhratsky, editors.
    1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain -- 2. Glutamate Metabolism in the Brain Focusing on Astrocytes -- 3. Glycogenolysis and Purinergic Signaling -- 4. Purinergic and Glutamatergic Receptors on Astroglia -- 5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP -- 6. Adenosine and Glutamate in Neuroglial Interaction: Implications for Circadian Disorders and Alcoholism -- 7. Purinergic Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria -- 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic White Matter Injury -- 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs -- 10. Ca2+ Signaling in Astrocytes and its Role in Ischemic Stroke -- 11. Pathological Potential of Astroglial Purinergic Receptors.
  • ScienceDirect
    edited by Alton Meister.
    Also available: Print – 1985
  • 2008 Springer
    edited by Robert W. Gereau IV and Geoffrey T. Swanson.
  • 2010 Springer
    Phil Skolnick, editor.
    N-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression / Phil Skolnick, Piotr Popik and Ramon Trullas -- Ionic Glutamate Modulators in Depression (Zinc, Magnesium) / Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc and Gabriel Nowak -- Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy / Eric S. Nisenbaum and Jeffrey M. Witkin -- Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors / Jeffrey M. Witkin -- Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders / Gary Lynch, Julie C. Lauterborn and Christine M. Gall -- Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia / Douglas J. Sheffler and P. Jeffrey Conn -- mGluR1 Negative Allosteric Modulators: An Alternative Metabotropic Approach for the Treatment of Schizophrenia / Hisashi Ohta, Hiroshi Kawamoto and Gentaroh Suzuki -- Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence / Svetlana Semenova and Athina Markou -- Metabotropic Approaches to Anxiety / Joanna M. Wieronska, Gabriel Nowak and Andrzej Pilc.
  • 2015 Springer
    Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors.
    This text is the first published volume for health professionals and advanced students that examines the biochemistry, clinical nutrition, and therapeutic aspects of glutamine. Drs. Rajendram, Preedy, and Patel are experts in their respective fields and have gathered an august list of contributors that represent the medical profession as well as the academic research community. Glutamine in Clinical Nutrition provides a timely, comprehensive, evidence-based review on the literature that presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. Notable topics include coverage on manganese toxicity and the glutamine-glutamate cycle, glutamine supplementation in HIV, glutamine addiction of cancer cells, glutamine supplementation during major surgery and in intensive care, and glutamine concerns with regards to sepsis, trauma, diabetes, and other diseases. The final chapter provides a wealth of information on web-based resources and suggested readings for the health provider. Written by authors of international and national standing, leaders in the field and trendsetters, Glutamine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, physicians, epidemiologists, policy makers, and health care professionals of various disciplines.
  • 2005 ScienceDirect
    edited by Helmut Sies, Lester Packer.
    Also available: Print – 2005
  • 2011 Springer
    Mauro S.G. Pavão, editor.
    Heparan sulfate proteoglycan in inflammation and angiogenesis / Lianchun Wang -- Heparan sulfate proteoglycans in infection / Allison H. Bartlett and Pyong Woo Park -- Glycans in cancer / Lubor Borsig -- Glycosaminoglycans in atherosclerosis and thrombosis / C.P. Vicente, J.A.P. Godoy, and C.C. Werneck -- Glycans in embryonic stem cells / Claire Pickford ... [et al.] -- Heparan sulfate proteoglycans in cancer therapy / Ezeddin Salem Gassar, Sherif A. Ibrahim, and Martin Götte -- Structure and biological activities of glycosaminoglycan analogs from marine invertebrates : new therapeutic agents? / Eliene O. Kozlowski ... [et al.]
    Also available: Print – 2011
  • 2011 Springer
    edited by Lillian F. Lien, Mary E. Cox, Mark N. Feinglos, Leonor Corsino ; foreword by Guillermo Umpierrez.
    Physiology of diabetes mellitus and types of insulin -- Subcutaneous insulin: a guide for dosing regimens in the hospital -- IV insulin infusions: how to use an "insulin drip" -- Laboratory testing in hospitalized patients with diabetes mellitus -- Inpatient diabetes education: realistic and evidence-based -- Hyperglycemic emergencies: diabetic ketoacidosis and hyperosmolar hyperglycemic state -- Medical nutrition therapy in the hospital -- Insulin pumps and glucose sensors in the hospital -- Non-insulin antidiabetic medications in the inpatient setting -- Hypoglycemia -- Transitioning to outpatient care -- Management of hyperglycemia associated with enteral and parenteral nutrition -- When to consult endocrinology -- Frequently asked questions.
  • 2007 Springer
    Akhlaq A. Farooqui and Lloyd A. Horrocks.
  • 2010 ScienceDirect
    edited by Minoru Fukuda.
    Also available: Print – 2010
  • 2006 ScienceDirect
    edited by Minoru Fukuda.
    Also available: Print – 2006
  • 2005 Springer
    edited by John S. Axford.
    Also available: Print – 2005
  • 2014 Springer
    Robert K. Yu, Cara-Lynne Schengrund, editors.
    Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- Introduction to Cells Comprising the Nervous System -- Synthesis, Processing, and Function of N-glycans in N-glycoproteins -- Synthesis of O-linked Glycoconjugates in the Nervous System -- Chemistry and Function of Glycosaminoglycans in the Nervous System -- Use of Glycan-targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System -- From Mass Spectrometry-based Glycosylation Analysis to Glycomics and Glycoproteomic -- Structural Analysis of Oligosaccharides and Glycoconjugates using NMR -- Glycolipid and Glycoprotein Expression During Neural Development -- Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System -- Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System -- Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a Glycosynapse -- Glycosignaling -- A General Review -- Glycosphingolipids in the Regulation of the Nervous System -- Glycobiology of Ion Transport in the Nervous System -- O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration -- N-glycosylation in Regulation of the Nervous System -- Roles of Carbohydrates in the Interaction of Pathogens with Neural Cells -- Glycoconjugate Changes in Aging and Age-related Diseases -- Gangliosides and Glycolipids in Neurodegenerative Disorders -- Glycosidases: Inborn Errors of Glycosphingolipid Catabolism -- Ganglioside Storage Diseases: On the Road to Management -- Dynamic Aspects of Neural Tumor Gangliosides -- Galectins and Neuroinflammation -- Glycoconjugates and Neuroimmunological Diseases.
  • 2006 Springer Protocols
    edited by Inka Brockhausen.
    Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction / Juan J. Garcia-Vallejo ... [et al.] -- Analysis of the glycodynamics of primary osteoblasts and bone cancer cells / Inka Brockhausen-Schutzbach, Xiaojing Yang, and Mark Harrison -- Micromethods for the characterization of lipid a core and o-antigen lipopolysaccharide / Cristina L. Marolda ... [et al.] -- Assays for a galactosyltransferase involved in the assembly of the O7 antigen repeat unit of escherichia coli / Inka Brockhausen-Schutzbach ... [et al.] -- High-throughput quantitation of metabolically labeled anionic glycoconjugates by scintillation proximity assay utilizing binding to cationic dyes / Karen J. Rees-Milton and Tassos P. Anastassiades -- Quantitative analysis of mucins in mucosal secretions using indirect ELISA / Pablo Argueso and Ilene K. Gipson -- Molecular dissection of the mouse zona pellucida: an electron microscopic perspective utilizing high-resolution colloidal-gold labeling methods / Frederick W. K. Kan -- Soluble adamantly glycosphingolipid analogs as probes of glycosphingolipid function / Clifford Lingwood ... [et al.] -- Diagnosis of Krabbe disease by use of a natural substrate / John W. Callahan and Marie-Anne Skomorowski -- In vitro assays of the functions of calnexin and calreticulin, lectin-chaperones of the endoplasmic reticulum / Breanna S. Ireland, Monika Niggemann, and David B. Williams -- Quantitative measurement of selectin-ligand interactions: assays to identify a sweet pill in a library of carbohydrates / Mark E. Beauharnois, Sriram Neelamegham, and Khushi L. Matta -- Sialic acid-binding specificities of siglecs / Nadine Bock and Soerge Kelm. The application of fluorophore-assisted carbohydrate -- Electrophoresis for the study of the dolichol pyrophosphate-linked oligosaccharides pathway in cell cultures and animal tissues / Ningguo Gao -- Partial purification of mannosylphosphorylundecaprenol synthase from micrococcus luteus: a useful enzyme for the biosynthesis of a variety of mannosylphosphorylpolyisoprenol products / Jeffrey S. Rush and Charles J. Waechter -- Assay of dolichyl-phospho-mannose synthase reconstituted in a lipid matrix / John S. Schutzbach -- O-mannosylation in mammalian cells / Tamao Endo and Hiroshi Manya -- Methods for analysis of unusual forms of o-glycosylation / Aleksandra Nita-Lazar and Robert S. Haltiwanger -- Structural analysis of naturally occurring sialic acids / Johannis P. Kamerling and Gerrit J. Gerwig -- Non-radioactive trans-sialidase screening assay / Silke Schrader and Roland Schauer -- Structural determination of o-glycans by tandem mass spectrometry / Catherine Robbe, Jean-Claude Michalski, and Calliope Capon -- Detailed structural analysis of n-glycans released from glycoproteins in SDS-page gel bands using HPLC combined with exoglycosidase array digestions / Louise Royle ... [et al.] -- Molecular modeling of glycosyltransferases / Anne Imberty ... [et al.] -- Galactoside_2,6-sialyltransferase (st6gal.i) and the sialyl_2,6-galactosyl-linkage in tissues and cell lines / Fabio Dall'Olio, Nadia Malagolini, and Mariella Chiricolo -- Visualizing intracellular distribution and activity of core 2 _(1,6)n-acetylglucosaminyltransferase-I (C2GNT-I) in living cells / Maelle Prorok-Hamon, Sylvie Mathieu, and Assou El-Battari --
  • 2015 Springer Protocols
    edited by Alexandra Castilho.
    Current approaches to engineering N-linked protein glycosylation in bacteria / Andreas Naegeli and Markus Aebi -- Inverse metabolic engineering for enhanced glycoprotein production in Escherichia coli / Stephen R. P. Jaffé, Benjamin Strutton, Jagroop Pandhal, and Phillip C. Wright -- GlycoSNAP : a high-throughput screening methodology for engineering designer glycosylation enzymes / Anne A. Ollis, Yi Chai, and Matthew P. DeLisa -- Production of glycoproteins with asparagine-linked N-acetylglucosamine in Escherichia coli / Flavio Schwarz and Markus Aebi -- Glyco-engineering O-antigen-based vaccines and eiagnostics in E. coli / Nicolas F. Vozza and Mario F. Feldman -- Progress in yeast glycosylation engineering / Stephen R. Hamilton and Dongxing Zha -- Protein production with a Pichia pastoris OCH1 knockout strain in fed-batch mode / Christoph Gmeiner and Oliver Spadiut -- Engineering the Pichia pastoris N-glycosylation pathway using the GlycoSwitch technology / Bram Laukens, Charlot De Wachter, and Nico Callewaert -- Development of a valuable yeast strain using a novel mutagenesis technique for the effective production of therapeutic glycoproteins / Hiroko Abe and Ken-ichi Nakayama -- An overview and history of glyco-engineering in insect expression systems / Christoph Geisler, Hideaki Mabashi-Asazuma, and Donald L. Jarvis 11 SweetBac : applying multiBac technology towards flexible modification of insect cell glycosylation / Dieter Palmberger and Dubravko Rendic -- Engineering sialic acid synthesis ability in insect cells / Karthik Viswanathan, Someet Narang, and Michael J. Betenbaugh -- Engineering N-glycosylation pathway in insect cells : suppression of [beta]-N-acetylglucosaminidase and expression of [beta]-1,4-galactosyltransferase / Yeon Kyu Kim and Hyung Joon Cha -- N-glyco-engineering in plants : update on strategies and major achievements / Herta Steinkellner and Alexandra Castilho -- Gene targeting for precision glyco-engineering : production of biopharmaceuticals devoid of plant-typical glycosylation in moss bioreactors / Eva L. Decker, Gertrud Wiedemann, and Ralf Reski -- Im"plant"ing of mammalian glycosyltransferase gene into plant suspension-cultured cells using agrobacterium-mediated transformation / Hiroyuki Kajiura and Kazuhito Fujiyama -- Transient glyco-engineering of N. benthamiana aiming at the synthesis of multi-antennary sialylated proteins / Andreas Loos and Alexandra Castilho -- Subcellular targeting of proteins involved in modification of plant N- and O-glycosylation / Martina Dicker, Jennifer Schoberer, Ulrike Vavra, and Richard Strasser -- Assembly of multigene constructs using golden gate cloning / Sylvestre Marillonnet and Stefan Werner -- Strategies for engineering protein N-glycosylation pathways in mammalian cells / Qiong Wang, Mark Stuczynski, Yuan Gao, and Michael J. Betenbaugh -- Glycan remodeling with processing inhibitors and lectin- resistant eukaryotic cells / Veronica T. Chang, Robert A. Spooner, Max Crispin, and Simon J. Davis -- Production of highly sialylated recombinant glycoproteins using Ricinus communis agglutinin-I-resistant CHO glycosylation mutants / John S. Y. Goh, Kah Fai Chan, and Zhiwei Song -- Metabolic glyco-engineering in eukaryotic cells and selected applications / Friedrich Piller, Aline Mongis, and Véronique Piller -- Evaluation of quenching and extraction methods for nucleotide/nucleotide sugar analysis / Katrin Braasch, Carina Villacrés, and Michael Butler -- Chemoenzymatic glyco-engineering of monoclonal antibodies / John P. Giddens and Lai-Xi Wang -- Chemical polysialylation of recombinant human proteins / Ivan V. Smirnov, Ivan I. Vorobiev, Alexey A. Belogurov, Dmitry D. Genkin, Sergey M. Deyev, and Alexander G. Gabibov -- Site-specific glycosylation profiling using liquid chromatography-tandem mass spectrometry (LC-MS) / Clemens Gruber and Friedrich Altmann -- Mass spectrometric analysis of oligo- and polysialic acids / Christina E. Galuska, Kai Maass, and Sebastian P. Galuska -- Isomer-specific analysis of released N-glycans by LC-ESI MS/MS with porous graphitized carbon / Daniel Kolarich, Markus Windwarder, Kathirvel Alagesan, and Friedrich Altmann.
  • 2015 Springer Protocols
    edited by Thomas Lütteke, Martin Frank.
    Annotation of glycomics MS and MS/MS spectra using the glycoworkbench software tool -- Glycobase and autogGU : resources for interpreting HPLC-glycan data -- NMR chemical shift prediction of glycans : application of the computer program CASPER in structural analysis -- Handling and conversion of carbohydrate sequence formats and monosaccharide notation -- Bacterial, plant, and fungal carbohydrate structure databases : daily usage -- Using NMR data on GLYCOSCIENCES.de -- Glycomic analysis using KEGG GLYCAN -- GlycomeDB -- Eukaryotic glycosylation : online methods for site prediction on protein sequences -- Analyzing glycan structure synthesis with the glycan pathway predictor (GPP) tool -- Functional network in posttranslational modifications : Glyco-Net in Glycoconjugate Data Bank -- JCGGDB : Japan Consortium for Glycobiology and Glycotechnology Database -- Glycan array data management at Consortium for Functional Glycomics -- Analyzing glycan-binding patterns with the profilepSTMM tool -- Exploring the specificities of glycan-binding proteins using glycan array data and the GlycoSearch software -- Statistical analysis of amino acids in the vicinity of carbohydrate residues performed by GlyVicinity -- Tools to assist determination and validation of carbohydrate 3D structure data -- Glyco3D : a portal for structural glycosciences -- Solution conformation of carbohydrates : a view by using NMR assisted by modeling -- Informing saccharide structural NMR studies with density functional theory calculations -- Energy maps for glycosidic linkage conformations -- Conformational analysis of oligosaccharides and polysaccharides using molecular dynamics simulations -- Molecular dynamics simulations of membrane- and protein-bound glycolipids using GLYCAM -- Lipopolysaccharide membrane building and simulation -- Molecular dynamics simulations of glycoproteins using CHARMM -- Calculating binding free energies for protein-carbohydrate complexes -- Scoring functions for AutoDock -- Structures of glycans bound to receptors from saturation transfer difference (STD) NMR spectroscopy : quantitative analysis by using CORCEMA-ST -- QM/MM methods for studying enzymatic reactions of glycosyltransferases.
  • 2010 ScienceDirect
    edited by Minoru Fukuda.
    Also available: Print – 2010
  • ScienceDirect
    edited by Minoru Fukuda.
    Carbohydrate-protein interactions, physical measurements -- Phage display library -- Glycosyltransferase expression profiling -- CHO mutants in glycan biosynthesis -- Function of sulfation -- Functions revealed by forced expression or gene knockout.
    Also available: Print – 2006
  • 2009 Springer Protocols
    edited by Nicolle H. Packer and Niclas G. Karlsson.
    Analysis of N- and O-linked glycans from glycoproteins using MALTI-TOF mass spectrometry / Willy Morelle ... [et al.] -- Infrared multiphoton dissociation mass spectrometry for structural elucidation of oligosaccharides / Bensheng Li ... [et al.] -- Mass spectrometry of N-linked glycans / Parastoo Azadi and Christian Heiss -- Solid-phase permethylation for glycomic analysis / Yehia Mechref, Pilsoo Kang, and Milos V. Novotny -- Method for investigation of oligosaccharides using phenylhydrazine derivatization / Erika Lattová and Hélène Perreault -- Two-dimensional HPLC separation with reverse-phase-nano-LC-MS/MS for the characterization of glycan pools after labeling with 2-aminobenzamide / Manfred Wuhrer, Carolien A.M. Koeleman, and André M. Deelder -- Capillary lectin-affinity electrophoresis for glycan analysis / Kazuaki Kakehi and Mitsuhiro Kinoshita -- Analysis of methylated O-glycan alditols by reversed-phase nanoLC coupled CAD-ESI mass spectrometry / Franz-Georg Hanisch and Stefan Müller -- High-throughput and high-sensitivity nano-LC/MS and MS/MS for O-glycan profiling / Hasse Karlsson ... [et al.] -- Collision-induced dissociation tandem mass spectrometry for structural elucidation of glycans / Bensheng Li ... [et al.] -- The structural elucidation of glycosaminoglycans / Vikas Prabhakar, Ishan Capila, and Ram Sasisekharan -- Labelling heparan sulphate saccharides with chromophore fluorescence and mass tags for HLC and MS separations / Mark Skidmore ... [et al.] -- Small-scale enzymatic digestion of glycoproteins and proteoglycans for analysis of oligosaccharides by LC-MS and FACE gel electrophoresis / Ruby P. Estrella ... [et al.] -- Enrichment strategies for glycopeptides / Shigeyasu Ito, Ko Hayama, and Jun Hirabayashi -- Introductory glycosylation analysis using SDS-PAGE and peptide mass fingerprinting / Nicole Wilson, Raina Simpson, and Catherine Cooper-Liddell -- Characterization of N-linked glycosylation on recombinant glycoproteins produced in Pichia pastoris using ESI-MS and MALDI-TOF / Bing Gong ... [et al.] -- N-glycosylation site analysis of human platelet proteins by hydrazide affinity capturing and LC-MS/MS / Urs Lewandrowski and Albert Sickmann -- LC/MSn for glycoprotein analysis : N-linked glycosylation analysis and peptide sequencing of glycopeptides / Nana Kawasaki, Satsuki Itoh, and Teruhide Yamaguchi -- Detecting the "O-GlcNAcome" : detection, purification, and analysis of O-GlcNAc modified proteins / Natasha E. Zachara -- Preparation of a glycan library using a variety of glycosyltrasferases [i.e. glycosyltransferases] / Hiromi Ito ... [et al.] -- Data mining the PDB for glyco-related data / Thomas Lütteke and Claus-W. von der Lieth -- Saccharide microarrays for high-throughput interrogation of glycan-protein binding interactions / Andrew K. Powell, Zheng-liang Zhi, and Jeremy E. Turnbull -- Glocosaminoglycan characterization methodologies probing biomolecular interactions / Vikas Prabhakar, Ishan Capila, and Ram Sasisekharan -- Development and characterization of antibodies to carbohydrate antigens / Jamie Heimburg-Molinaro and Kate Rittenhouse-Olson -- Inhibition of glcosyltransferase activities as the basis for drug development / John Schutzbach and Inka Brockhausen -- Saturation transfer difference NMR spectroscopy as a technique to investigate protein-carbohydrate interactions in solution / Thomas Haselhorst, Anne-Christin Lamerz, and Mark von Izstein.
  • 2015 Springer Protocols
    edited by Kuberan Balagurunathan, Hiroshi Nakato, Umesh R. Desai.
    Automated Synthesis of Chondroitin Sulfate Oligosaccharides / Chien-Fu Liang, Heung Sik Hahm, and Peter H. Seeberger -- Enzymatic Synthesis of Heparan Sulfate and Heparin / April Joice [and six others] -- Production of Size-Defined Heparosan, Heparan Sulfate, and Heparin Oligosaccharides by Enzymatic Depolymerization / Spencer Brown and Balagurunathan Kuberan -- Chemical Modification of Heparin and Heparosan / Karthik Raman, Balagurunathan Kuberan, and Sailaja Arungundram -- Synthesis of Sulfur Isotope-Labeled Sulfate Donor, 3'-Phosphoadenosine-5'- Phosphosulfate, for Studying Glycosaminoglycan Functions/ Caitlin Mencio [and three others] -- Preparation of Isotope-Enriched Heparan Sulfate Precursors for Structural Biology Studies / Xylophone V. Victor [and three others] -- Synthesis of Glycosaminoglycan Mimetics Through Sulfation of Polyphenols / Rami A. Al-Horani [and three others] -- Synthesis of Selective Inhibitors of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis / Caitlin Mencio [and three others] -- Ascidian (Chordata-Tunicata) Glycosaminoglycans : Extraction, Purification, Biochemical, and Spectroscopic Analysis / Mauro S.G. Pavão -- Human Blood Glycosaminoglycans : Isolation and Analysis / Md. Ferdous Anower-E-Khuda and Koji Kimata -- Chromatographic Molecular Weight Measurements for Heparin, Its Fragments and Fractions, and Other Glycosaminoglycans / Barbara Mulloy and John Hogwood -- Mass Spectrometric Methods for the Analysis of Heparin and Heparan Sulfate / Miroslaw Lech, Ishan Capila, and Ganesh V. Kaundinya -- Validated Capillary Electrophoretic Assays for Disaccharide Composition Analysis of Galactosaminoglycans in Biologic Samples and Drugs/Nutraceuticals / Athanasia P. Asimakopoulou [and five others] -- Fast Screening of Glycosaminoglycan Disaccharides by Fluorophore-Assisted Carbohydrate Electrophoresis (FACE) : Applications to Biologic Samples and Pharmaceutical Formulations / Evgenia Karousou [and seven others] -- Capillary Electrophoretic Analysis of Isolated Sulfated Polysaccharides to Characterize Pharmaceutical Products / Zachary Shriver and Ram Sasisekharan -- Methods for Measuring Exchangeable Protons in Glycosaminoglycans / Consuelo N. Beecher and Cynthia K. Larive -- Heparan Sulfate Structure : Methods to Study N-Sulfation and NDST Action / Anders Dagälv [and five others] -- Analysis of Hyaluronan Synthase Activity / Davide Vigetti [and three others] -- A Rapid, Nonradioactive Assay for Measuring Heparan Sulfate C-5 Epimerase Activity Using Hydrogen/Deuterium Exchange-Mass Spectrometry / Ponnusamy Babu [and three others] -- Aggrecan : Approaches to Study Biophysical and Biomechanical Properties / Hadi Tavakoli Nia, Christine Ortiz, and Alan Grodzinsky -- Use of Flow Cytometry for Characterization and Fractionation of Cell Populations Based on Their Expression of Heparan Sulfate Epitopes / Rebecca J. Holley [and five others] -- A Transgenic Approach to Live Imaging of Heparan Sulfate Modification Patterns / Matthew Attreed and Hannes E. Bülow -- Informatics Tools to Advance the Biology of Glycosaminoglycans and Proteoglycans / Lewis J. Frey -- Designing "High-Affinity, High-Specificity" Glycosaminoglycan Sequences Through Computerized Modeling / Nehru Viji Sankaranarayanan [and three others] -- Using Isothermal Titration Calorimetry to Determine Thermodynamic Parameters of Protein-Glycosaminoglycan Interactions/ Amit K. Dutta, Jörg Rösgen, and Krishna Rajarathnam -- Characterizing Protein-Glycosaminoglycan Interactions Using Solution NMR Spectroscopy / Prem Raj B. Joseph, Krishna Mohan Poluri, Krishna Mohan Sepuru, and Krishna Rajarathnam -- Glycosaminoglycan-Protein Interaction Studies Using Fluorescence Spectroscopy / Rio S. Boothello, Rami A. Al-Horani, and Umesh R. Desai -- Studying Glycosaminoglycan-Protein Interactions Using Capillary Electrophoresis / Aiye Liang and Umesh R. Desai -- Histochemical Analysis of Heparan Sulfate 3-O-Sulfotransferase Expression in Mouse Brain / Tomio Yabe and Nobuaki Maeda -- Keratan Sulfate : Biosynthesis, Structures, and Biological Functions / Kenji Uchimura -- The Sulfs : Expression, Purification, and Substrate Specificity / Kenji Uchimura -- The Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues / Marika Bogdani [and five others] -- Nonradioactive Glycosyltransferase and Sulfotransferase Assay to Study Glycosaminoglycan Biosynthesis / Cheryl M. Ethen [and five others] -- Mapping Proteoglycan Functions with Glycosidases / Mauricio Cortes, Leslie K. Cortes, and Nancy B. Schwartz -- Cell Substrate Patterning with Glycosaminoglycans to Study Their Biological Roles in the Central Nervous System / Tony W. Hsiao [and three others] -- Analyzing the Role of Heparan Sulfate Proteoglycans in Axon Guidance In Vivo in Zebrafish / Fabienne E. Poulain -- Murine Models in the Evaluation of Heparan Sulfate-Based Anticoagulants / David Gailani, Qiufang Cheng, and Ivan S. Ivanov -- Genetic Approaches in the Study of Heparan Sulfate Functions in Drosophila / Masahiko Takemura and Hiroshi Nakato -- Measuring Sulfatase Expression and Invasion in Glioblastoma / Anna Wade [and three others] -- Synthesis and Biomedical Applications of Xylosides / Mausam Kalita [and four others] -- A Strategic Approach to Identification of Selective Inhibitors of Cancer Stem Cells / Nirmita Patel, Somesh Baranwal, and Bhaumik B. Patel -- Analysis of the Heavy-Chain Modification and TSG-6 Activity in Pathological Hyaluronan Matrices / Mark E. Lauer [and three others] -- Heparan Sulfate Modulates Slit3-Induced Endothelial Cell Migration / Hong Qiu [and three others] -- Glycosaminoglycan Functionalized Nanoparticles Exploit Glycosaminoglycan Functions / James A. Vassie, John M. Whitelock, and Megan S. Lord -- Role of Glycosaminoglycans in Infectious Disease / Akiko Jinno and Pyong Woo Park -- Isolation and Purification of Versican and Analysis of Versican Proteolysis / Simon J. Foulcer, Anthony J. Day, and Suneel S. Apte -- Analysis of Human Hyaluronan Synthase Gene Transcriptional Regulation and Downstream Hyaluronan Cell Surface Receptor Mobility in Myofibroblast Differentiation / Adam C. Midgley and Timothy Bowen.
  • 2015 ScienceDirect
    edited by Richard R. Drake and Lauren E. Ball.
  • 2013 Springer Protocols
    edited by Alain Beck.
    Engineering of therapeutic and diagnostic o-glycans on recombinant mucin-type immunoglobulin fusion proteins expressed in CHO cel / Linda Lindberg, Jining Liu, and Jan Holgersson -- Engineering a human-like glycosylation to produce therapeutic glycoproteins based on 6-linked sialylation in CHO cells / Nassimal El Maï [and others] -- Glycoengineered pichia-based expression of monoclonal antibodies / Dongxing Zha -- N-glycosylation humanization for production of therapeutic recombinant glycoproteins in Saccharomyces cerevisiae / Christelle Arico, Christine Bonnet, and Christophe Javaud -- Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells / Sylvie Juliant [and others] -- NanoLC chips MS/MS for the characterization of n-glycopeptides generated from trypsin digestion of a monoclonal antibody / Elsa Wagner-Rousset [and others] -- Cetuximab Fab and Fc n-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry / Marie-Claire Janin-Bussat [and others] -- Therapeutic antibody glycosylation analysis : a contract research organization perspective in the frame of batch release or comparability support / Arnaud Delobel [and others] -- Mass spectrometric analysis of o-linked oligosaccharides from various recombinant expression systems / Diarmuid T. Kenny [and others] -- Assessing Fc glycan heterogeneity of therapeutic recombinant monoclonal antibodies using NP-HPLC / T. Shantha Raju -- Application of capillary electrophoresis in glycoprotein analysis / Richard R. Rustandi, Carrie Anderson, and Melissa Hamm -- Characterization of glycoprotein biopharmaceutical products by caliper LC90 CE-SDS gel technology / Grace Chen, Sha Ha, and Richard R. Rustandi -- Hydrophobic interaction chromatography to analyze glycoproteins / Richard R. Rustandi -- Lectin glycoprofiling of recombinant therapeutic interleukin-7 / Ludovic Landemarre and Eric Duverger -- Analysis of monoclonal antibodies by sedimentation velocity analytical ultracentrifugation / W. Blaine Stine Jr. -- Noncovalent mass spectrometry for the characterization of antibody/antigen complexes / Cédric Atmanene [and others] -- Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry / Damian Houde and John R. Engen -- Epitope mapping of antibodies by mass spectroscopy : a case study / Victor H. Obungu, Valentina Gelfanova, and Lihua Huang -- Evaluation of antibody-dependent cell cytotoxicity using lactate dehydrogenase (LDH) measurement / Matthieu Broussas, Lucile Broyer, and Liliane Goetsch -- Evaluation of complement-dependent cytotoxicity using ATP measurement and C1q/C4b binding / Lucile Broyer, Liliane Goetsch, and Matthieu Broussas -- Capture of the human IgG1 antibodies by protein A for the kinetic study of h-IgG/FcgR interaction using SPR-based biosensor technology / Thierry Champion and Alain Beck -- Mass spectrometry protocol for the absolute quantification of a monoclonal antibody in serum with immunopurification / François Becher [and others].
  • 2013 Springer Protocols
    edited by Inka Brockhausen.
    Glycan microarray screening assay for glycosyltransferase specificities / W. Peng, C.M. Nycholat and N. Razi -- A fluorescence-based assay for core 1 [beta]3galactosyltransferase (T-synthase) activity / T. Ju and R.D. Cummings -- Structural and biochemical analysis of a bacterial glycosyltransferase / F. Zhu ... [et al.] -- Study of the biological functions of mucin type core 3 O-glycans / S.H. Lee and M. Fukuda -- Generation of anti-sulfated glycan antibodies using sulfotransferase-deficient mice / H. Kawashima -- Fluorescent microscopy as a tool to elucidate dysfunction and mislocalization of golgi glycosyltransferases in COG complex depleted mammalian cells / R.A. Willett, I.D. Pokrovskaya and V.V. Lupashin -- A practical approach to reconstruct evolutionary history of animal sialyltransferases and gain insights into the sequence-function relationships of golgi-glycosyltransferases / D. Petit ... [et al.] -- Fluorescent lectin staining of drosophila embryos and tissues to detect the spatial distribution of glycans during development / E. Tian, L. Zhang and K.G. Ten Hagen -- Photoaffinity labeling of protein O-mannosyltransferases of the PMT1/PMT2 subfamily / M. Loibl and S. Strahl -- Enzymatic analysis of the protein O-glycosyltransferase, rumi, acting toward epidermal growth factor-like (egf) repeats / H. Takeuchi and R.S. Haltiwanger -- Enzymatic characterization of recombinant enzymes of O-glcNAc cycling / E.J. Kim and J.A. Hanover -- Antibodies and activity measurements for the detection of o-glcnac transferase and assay of its substrate, UDP-glcNAc / T. Lefebvre ... [et al.] -- In vitro glycosylation assay for bacterial oligosaccharyltransferases / M.A. Musumeci, M.V. Ielmini and M.F. Feldman -- In vitro UDP-sugar:Undecaprenyl-phosphate sugar-1-phosphate transferase assay and product detection by thin layer chromatography / K.B. Patel and M.A. Valvano -- In vitro O-antigen ligase assay / X. Ruan and M.A. Valvano -- Functional identification of bacterial glucosyltransferase WbdN / Y. Gao, A. Vinnikova and I. Brockhausen -- Methods for the pasteurella glycosaminoglycan synthases: Enzymes that polymerize hyaluronan, chondroitin, or heparosan chains / P.L. Deangelis -- Methods for measuring class i membrane-bound hyaluronan synthase activity / P.H. Weigel, A.J. Padgett-McCue and B.A. Baggenstoss -- Creation and characterization of glycosyltransferase mutants of Trypanosoma brucei / L. Izquierdo, M.L. Guther and M.A. Ferguson -- Mannose-6-phosphate: A regulator of LLO destruction / N. Gao and M.A. Lehrman -- N-acetylglucosaminyltransferase (GnT) assays using fluorescent oligosaccharide acceptor substrates: GnT-III, IV, V, and IX (GnT-Vb) / S. Takamatsu ... [et al.] -- A method for determination of UDP-GlcNAc: GlcNAc[beta]1-6(GlcNAc[beta]1-2)man[alpha]1-r [GlcNAc to man] beta1-4n-acetylglucosaminyltransferase vi activity / T. Taguchi and N. Taniguchi -- In vitro assays of orphan glycosyltransferases and their application to identify notch xylosyltransferases / M.K. Sethi ... [et al.] -- In vitro folding of [beta]-1,4galactosyltransferase and polypeptide-[alpha]-N-acetylgalactosaminyltransferase from the inclusion bodies / B. Ramakrishnan and P.K. Qasba -- An assay for [alpha] 1,6-fucosyltransferase (FUT8) activity based on the HPLC separation of a reaction product with fluorescence detection / H. Ihara ... [et al.] -- Immunodetection of glycosyltransferases in gastrointestinal tissues / J. Gomes and C.A. Reis -- Glycosyltransferases in chemo-enzymatic synthesis of oligosaccharides / B. Tefsen and I. van Die -- Tumor targeting by a carbohydrate ligand-mimicking peptide / S. Hatakeyama ... [et al.] -- Glycoengineering of human cell lines using zinc finger nuclease gene targeting: Simple cells with homogeneous GalNAc O-glycosylation allow isolation of the O-glycoproteome by one-step lectin affinity chromatography / C. Steentoft, E.P. Bennett and H. Clausen -- Generation of monoclonal antibodies to native active human glycosyltransferases / M.B. Vester-Christensen ... [et al.].
  • 2007 Springer Protocols
    edited by Richard J. Sugrue.
    The use of monoclonal antibodies and lectins to identify changes in viral glycoproteins that are influenced by glycosylation : the case of respiratory syncytial virus attachment (G) glycoprotein / Joanna Rawling and José A. Melero -- Expression, glycosylation, and modification of the spike (S) glycoprotein of SARS-CoV / Shuo Shen, Timothy H.P. Tan, and Yee-Joo Tan -- Analysis of glycoproteins of viruses in the family bunyaviridae / Xiaohong Shi and Richard M. Elliott -- Secretion of respiratory syncytial virus fusion protein from insect cells using the baculovirus expression system / Boon-Huan Tan, Gaie Brown, and Richard J. Sugrue -- Characterization of the dengue virus envelope glycoprotein expressed in Pichia pastoris / Boon-Huan Tan, Jian Lin Fu, and Richard J. Sugrue -- Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins / Alexander W. Tarr ... [et al.]. Viruses and glycosylation : an overview / Richard J. Sugrue -- Interaction between respiratory syncytial virus and glycosaminoglycans, including heparan sulfate / Louay K. Hallak, Steven A. Kwilas, and Mark E. Peeples -- Expression of the severe acute respiratory syndrome coronavirus 3a protein and the assembly of coronavirus-like particles in the baculovirus expression system / Sehaam Khan, Mah-Lee Ng, and Yee-Joo Tan -- The C type lectins DC-SIGN and L-SIGN : receptors for viral glycoproteins / Pierre-Yves Lozach ... [et al.] -- Functional analysis of the N-linked glycans within the fusion protein of respiratory syncytial virus / Ping Li ... [et al.] -- Expression and purification of viral glycoproteins using recombinant vaccinia viruses for functional and structural studies / Zhu-Nan Li and David A. Steinhauer -- The use of two-dimensional SDS-PAGE to analyze the glycan heterogeneity of the respiratory syncytial virus fusion protein / Terence P. McDonald and Richard J. Sugrue --
  • 2011
    Drew Alexander Hall.
    Nanotechnology has had a transformative effect on medical diagnostics due to the influx of new sensing modalities and transducers. Magnetic nanotechnologies, in particular, have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors, commonly used in hard disk drives, coupled with magnetic nanotags have shown great promise as biosensors. In this work, we present several custom designed circuit interface and readout systems tailored to specific application spaces and their unique needs. Taken together, we have demonstrated that innovative electronic circuits play an indispensable role in unlocking the tremendous potential of nanosensors in the biomedical arena. The first system was designed for ultrasensitive early cancer diagnostics and built using off-the-shelf components for an 8x8 array of GMR SV sensors. At the core of this design, we demonstrate a new circuit architecture based on a transimpedance amplifier (TIA) with a carrier suppression technique to reduce the dynamic range requirement and a multiplexing scheme to reduce the readout time. This system is capable of real-time, multiplex detection with a detection limit of 5 femtomolar (fM) and over 6 orders of linear dynamic range. The second system is a miniaturized, portable platform called the nanoLAB. Although there is a growing need for point-of-care (POC) testing for global health, the current options are bulky, slow, expensive, and often not sensitive. The nanoLAB addresses these needs and pushes the state of the art with sensitive 8-plex detection using a wash-free assay that can be run by anyone, anywhere. This platform was tested and validated using human immunodeficiency virus (HIV) biomarkers with detection down to 50 fM in as little as 15 minutes. We also show how a GMR SV biosensor can be integrated into a continuous time sigma delta modulator. This proof-of-concept hybrid sigma delta modulator has a peak SNR of 99.3 dB and a dynamic range of over 92 dB in a 1 kHz bandwidth using the sensor as part of the first integrator. The carrier suppression and multiplexing concepts were also incorporated into the hybrid sigma delta modulator. Lastly, we conclude by describing an integrated platform for a large 16x16 array of GMR SV sensors implemented in a 0.18 [mu]m CMOS technology. Arranged like an imager chip, each of the 16 column level readout channels contains an analog front-end and an analog-to-digital converter. Each readout channel occupies less than 0.2 mm^2 of chip area and consumes 3.4 mW of power. This system is designed as a replacement for optical protein microarrays while being fully quantitative and providing real-time readout.
  • 2008 HighWire
    edited by Gilles Montalescot.
  • 2012
    Victoria Sweet.
    Status: Not Checked OutLane Catalog Record
    "San Francisco's Laguna Honda Hospital is the last almshouse in the country, a descendant of the Hotel-Dieu (God's Hotel) that cared for the sick in the Middle Ages. Ballet dancers and rock musicians, professors and thieves--"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul"--Provided by publisher. "Choosing service in the last remaining almshouse in America, and tracing our understanding of medicine back to its medieval roots, a physician uncovers lost lessons in the care of body and soul"--Provided by publisher. Includes detailed explorations of Hildegard's medical practice and its occasional unexpected utility for modern problems.
  • 2013
    [commentary and translations by] Ioannis Solos ; forewords by Professor Liang Rong and Professor Chen Jia-xu.
    Status: Not Checked OutLane Catalog Record
  • 2013 ClinicalKey
    Ary L. Goldberger, Zachary D. Goldberger, Alexei Shvilkin.
    Key concepts -- ECG basics : waves, intervals, and segments -- ECG leads -- Understanding the normal ECG -- Electrical axis and axis deviation -- Atrial and ventricular enlargement -- Ventricular conduction disturbances : bundle branch blocks and related abnormalities -- Myocardial infarction and ischemia, I : ST segment elevation and non-Q wave -- Syndromes -- Myocardial infarction and ischemia, II : non-ST segment elevation and non-Q wave syndromes -- Drug effects, electrolyte abnormalities, and metabolic effects -- Pericardial, myocardial and pulmonary syndromes -- Wolff-Parkinson-White preexcitation syndromes -- Sinus and escape rhythms -- Supraventricular arrhythmias, part I : premature beats and paroxysmal supraventricular tachycardias (PSVTS) -- Supraventricular arrhythmias, part II : atrial flutter and atrial fibrillation -- Ventricular arrhythmias -- Atrioventricular (AV) conduction abnormalities : delays, blocks, and dissociation syndromes -- Digitalis toxicity -- Sudden cardiac arrest and sudden cardiac death -- Bradycardias and tachycardias : review and differential diagnosis -- Pacemakers and implantable cardioverter-defibrillators (ICDs) : essentials for clinicians -- How to interpret an ECG -- Limitations and uses of the ECG -- ECG differential diagnoses : instant reviews.
  • 2008 Springer
    edited by Gary W. Barrett, George A. Feldhamer.
    The golden mouse : a levels-of-organization perspective / Gary W. Barrett -- The golden mouse : taxonomy and natural history / George A. Feldhamer and Donald W. Linzey -- Population ecology of the golden mouse / Robert K. Rose -- Community ecology of the golden mouse / Cory C. Christopher and Guy N. Cameron -- Ecosystem ecology of the golden mouse / Steven W. Seagle -- Landscape ecology of the golden mouse / Jerry O. Wolff and Gary W. Barrett -- Relative abundance and conservation : is the golden mouse a rare species? / George A. Feldhamer and Anita T. Morzillo -- The golden mouse : a model of energetic efficiency / John D. Peles and Gary W. Barrett -- Nesting ecology of the golden mouse : an oikos engineer / Thomas M. Luhring and Gary W. Barrett -- Ectoparasites, bots, and vector-borne diseases associated with the golden mouse / Lance A. Durden -- Aesthetic landscapes of the golden mouse / Terry L. Barrett and Gary W. Barrett -- Future challenges and research opportunities : what do we really know? / Gary W. Barrett and George A. Feldhamer.
  • 2015 AccessEmergency Medicine
    [edited by] Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S. Nelson, Lewis R. Goldfrank ; editor emeritus Neal E. Flomenbaum.
    Pt. A: The general approach to medical toxicology -- Pt. B: The fundamental principles of medical toxicology -- Sect. I: Biochemcial and molecular basis -- Sect. II: Pathophysiologic basis: organ systems -- Sect. III: Special populations -- Pt. C: The clinical basis of medical toxicology -- Sect. I: A: Analgesics and antinflammatory medications -- B: Food, diet, and nutrition -- C: Pharmaceuticals -- D: Antimicrobials -- E: Cardiopulmonary medications -- F: Anesthetics and related medications -- G: Psychotropics -- H: Substances of abuse -- I: Metals -- J: Household products -- K: Pesticides -- L: Natural toxins and envenomations -- M: Occupational and environmental toxins -- N: Disaster preparedness -- Sect. II: Poison centers and epidemiology.
  • 2006
    [edited by] Neal E. Flomenbaum ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2016 ClinicalKey
    [edited by] Lee Goldman, and Andrew I. Schafer.
    In the 90 years since the first edition of the Cecil Textbook of Medicine was published, almost everything we know about internal medicine has changed. Progress in medical science is now occurring at an ever-accelerating pace, and it is doing so within the framework of transformational changes in clinical practice and the delivery of health care at individual, social, and global levels. However, we have remained true to the tradition of a comprehensive textbook of medicine that carefully explains the why (the underlying pathophysiology of disease) and the how (now expected to be evidence-based from randomized controlled trials and meta-analyses). In short-- Goldman-Cecil Medicine offers definitive, unbiased guidance on the evaluation and management of every medical condition.
  • 2012 ScienceDirect
    [edited by] Lee Goldman, Andrew I. Schafer.
    Social and ethical issues in medicine -- Principles of evaluation and management -- Preventive and environmental issues -- Aging and geriatric medicine -- Clinical pharmacology -- Genetics -- Principles of immunology and inflammation -- Cardiovascular disease -- Respiratory diseases -- Critical care medicine -- Renal and genitourinary diseases -- Gastrointestinal diseases -- Diseases of the liver, gallbladder, and bile ducts -- Hematologic diseases -- Oncology -- Metabolic diseases -- Nutritional diseases -- Endocrine diseases -- Women's health -- Diseases of bone and mineral metabolism -- Diseases of allergy and clinical immunology -- Rheumatic diseases -- Infectious diseases -- HIV and the acquired immunodeficiency syndrome -- Neurology -- Eye, ear, nose, and throat diseases -- Medical consultation -- Skin diseases.
  • 2009 Springer
    D. James Morré, Hilton H. Mollenhauer.
  • 2016 Springer
    Nao Suzuki, Jacques Donnez, editors.
    This book is a practical guide to the cryopreservation and transplantation of oocytes, embryos, and ovarian and testicular tissue for fertility preservation. Illustrated with a wealth of figures and photos, it provides updated techniques for clinicians, technicians, and researchers. This book also gives insights into in vitro activation (IVA), in vitro growing (IVG), and in vitro maturation (IVM), with both basic research and future directions. These techniques combined with cryopreservation will improve the chances of reproduction. Cryopreservation is essential to protect fertility in cancer patients who undergo treatment with radioiodine or chemotherapy, which may cause damage to their reproductive organs, and also for primary ovarian insufficiency patients. The book also includes a chapter on the risk of the presence of malignant cells in ovarian tissue. Both editors are pioneering researchers in this field.
  • 2002 ScienceDirect
    edited by Ishwar S. Parhar.
    Section I. Development and cell migration -- Section II. GnRH receptors -- Section III. Physiology and regulation.
    Also available: Print – 2002
  • 2012 Springer
    Christoph Faschinger, Anton Hommer.
    Gonioscopy is a very important differential diagnostic tool that permits assessment of the anterior chamber angle and correct classification of glaucoma as a basis for specific treatment. This book clearly explains how to perform gonioscopy to best effect. The anatomy of the chamber angle is systematically described, and the impact of age, developmental disorders, and other pathologies on the chamber angle is explained. Particular attention is focused on primary and secondary open-angle and angle-closure glaucomas. In each case, the role of gonioscopy in evaluating the chamber angle is described with the help of many photographs and illustrations. The importance of knowledge of the chamber angle for laser treatment and surgery is fully explained, and the impact of medications is discussed. The practitioner will find in Gonioscopy all the information required to use the technique effectively in diagnosis and treatment.
  • 2013 Springer
    Terrence P. Tougas, Jolyon P. Mitchell, Svetlana A. Lyapustina, editors.
    Introduction / Terrence P. Tougas, Jolyon P. Mitchell -- Current Approaches to APSD Measurements of OIPs Based on Inertial Impaction / Jolyon P. Mitchell, Daryl L. Roberts -- Physical Causes of APSD Changes in Aerosols from OIPs and Their Impact on CI Measurements / Helen Strickland, Beth Morgan -- Good Cascade Impactor Practices / Jolyon P. Mitchell -- The AIM and EDA Concepts: Why They Are Needed and How They Fit Together / Jolyon P. Mitchell, Terrence P. Tougas -- Product Life Cycle Approach to Cascade Impaction Measurements / Richard Bauer, J. David Christopher -- Theoretical Basis for the EDA Concept / Terrence P. Tougas, Jolyon P. Mitchell -- Performance Characterization of EDA and Its Potential to Improve Decision Making in Product Batch Release / J. David Christopher, Helen Strickland -- Verification of the EDA Concept Through an Assessment of Theoretical Failure Modes, Failure Mode Analysis, and Case Studies with Real Data / Helen Strickland, Beth Morgan -- Validating AIM-Based Instrumentation and Associated Measurement Techniques / Mark Copley, Jolyon P. Mitchell -- The Regulatory and Compendial Pathways to Acceptance for AIM and EDA Concepts / Steven C. Nichols, Jolyon P. Mitchell -- Applying the AIM Concept in Support of Developing Improved In Vitro-In Vivo Relationships for OIPs / Jolyon P. Mitchell, Mark Copley -- Future Directions for the AIM and EDA Concepts / Terrence P. Tougas, Jolyon P. Mitchell -- Conclusions / Terrence P. Tougas, Svetlana A. Lyapustina.
  • 2014
    Barron H. Lerner, MD.
    Status: Not Checked OutLane Catalog Record
    The first Dr. Lerner -- Super doctor -- Illness hits home -- The second Dr. Lerner -- Forging my own path -- Treating the whole patient -- Family practitioner -- Growing disillusionment -- Slowing down -- Epilogue.
  • 2001 CRCnetBASE
    Sidney H. Willig.
    Also available: Print – 2001
  • 2007
    edited by Joseph D. Nally.
    Status: Not Checked OutLane Catalog Record
    Preface / Joseph D. Nally -- Contributors -- 1. Status and Applicability of U.S. Regulations: Current Good Manufacturing Practices in Manufacturing, Processing, Packaging, and Holding of Drugs / Joseph D. Nally -- 2. Finished Pharmaceuticals: General Provisions, Subpart A / Joseph D. Nally -- 3. Organization and Personnel, Subpart B / Joanne W. Cochran and Joseph D. Nally -- 4. Buildings and Facilities, Subpart C / Robert Del Ciello -- 5. Equipment, Subpart D / Robert Del Ciello, Joseph T. Busfield, and Steven Ostrove -- 6. Control of Components and Drug Product Containers and Closures , Subpart E / Arlyn R. Sibille -- 7. Production and Process Controls, Subpart F / Joseph D. Nally and Michael D. Karaim -- 8. Packaging and Labeling Control, Subpart G / Arlyn R. Sibille -- 9. Holding Distribution, Subpart H / Joseph D. Nally -- 10. Laboratory Controls, Subpart I / Wayne J. DeWitte and Lex M. Hoinowski -- 11. Records and Reports, Subpart J / Arlyn R. Sibille, Steven Ostrove, Joseph D. Nally, and Laura L. Nally -- 12. Returned and Salvaged Drug Products, Subpart K / Joseph D. Nally -- 13. Repacking and Relabeling / Joseph D. Nally -- 14. Quality Systems and Risk Management Approaches / Joseph D. Nally and Laura L. Nally -- 15. Clinical Trial Supplies and Current Good Manufacturing / Graham Bunn -- 16. Contracting and Outsourcing / Graham Bunn -- 17. Active Pharmaceutical Ingredients / P. Denis Celentano -- 18. Bulk Pharmaceutical Excipient GMPs / Irwin Silverstein -- 19. Recalls, Warning Letters, Seizures and Injunctions: CGMP Enforcement Alternatives in the United States / Joseph D. Nally -- 20. Control Substances Safeguards (21 CFR 1300, et seq.) / Joseph D. Nally -- 21. The Inspection Procedures for Compliance in the United States: The Regulatee is Inspected; The Rational for Inspection (21 USC 373, 374) / Joseph D. Nally -- 22. FDA Pre-Approval Inspections/Investigations: The Road from Scale-Up and Post-Approval Changes in the Food and Drug Modernization Act / Joseph D. Nally -- 23. World-Wide Good Manufacturings Practices / Joseph D. Nally -- 24. Quality Approaches: ISO 9000, Malcolm Baldrige, and Six Sigma / Joseph D. Nally -- Appendix A: Center for Drug Evaluation and Research: List of Guidance Documents -- Appendix B: ICH Guidelines -- Appendix C: Food and Drug Administration (FDA) Office Regulatory Affairs (ORA) Compliance Policy Guides -- Index.
  • 2011 (12th ed.) AccessMedicine
    [editors] Laurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann.
    Drug invention and the pharmaceutical industry -- Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination -- Pharmacodynamics: molecular mechanisms of drug action -- Drug toxicity and poisoning -- Membrane transporters and drug response -- Drug metabolism -- Pharmacogenetics -- Neurotransmission: the autonomic and somatic motor nervous systems -- Muscarinic receptor agonists and antagonists -- Anticholinesterase agents -- Agents acting at the neuromuscular junction and autonomic ganglia -- Adrenergic agonists and antagonists -- 5-Hydroxytryptamine (serotonin) and dopamine -- Neurotransmission and the central nervous system -- Drug therapy of depression and anxiety disorders -- Pharmacotherapy of psychosis and mania -- Hyponotics and sedatives -- -- Opioids, analgesia, and pain management -- General anesthetics and therapeutic gases -- Local anesthetics -- Pharmacotherapy of the epilepsies -- Treatment of central nervous system degenerative disorders -- Ethanol and methanol -- Drug addiction -- Regulation of renal function and vascular volume -- Renin and angiotensin -- Treatment of myocardial ischemia and hypertension -- Pharmacotherapy of congestive heart failure -- Anti-arrhythmic drugs -- Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs -- Drug therapy for hypercholesterolemia and dyslipidemia -- Histamine, bradykinin, and their antagonists -- Lipid-derived autacoids: eicosanoids and platelet-activating factor -- Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout -- Immunosuppressants, tolerogens, and immunostimulants -- Pulmonary pharmacology -- Hematopoietic agents: growth factors, minerals, and vitamins -- Introduction to endocrinology: the hypothalamic-pituitary axis -- Thyroid and anti-thyroid drugs -- Estrogens and progestins -- Androgens -- ACTH, adrenal steroids, and pharmacology of the adrenal cortex -- Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia -- Agents affecting mineral ion homeostasis and bone turnover -- Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease -- Treatment of disorders of bowel motility and water flux; anti-emetics; agents used in biliary and pancreatic disease -- Pharmacotherapy of inflammatory bowel disease -- General principles of antimicrobial therapy -- Chemotherapy of malaria -- Chemotherapy of protozoal infections: amebiasis, giardiasis, trichomoniasis, trypanosomiasis, leishmaniasis, and other protozoal infections -- Chemotherapy of helminth infections -- Sulfonamides, trimethoprim-sulfamethoxazole, quinolones, and agents for urinary tract infections -- Penicillins, cephalosporins, and other β-lactam antibiotics -- Aminoglycosides -- Protein synthesis inhibitors and miscellaneous antibacterial agents -- Chemotherapy of tuberculosis, mycobacterium avium complex disease, and leprosy -- Antifungal agents -- Antiviral agents (nonretroviral) -- Antiretroviral agents and treatment of HIV infection -- General principles of cancer chemotherapy -- Cytotoxic agents -- Targeted therapies: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines -- Natural products in cancer chemotherapy: hormones and related agents -- Ocular pharmacology -- Dermatological pharmacology -- Contraception and pharmacotherapy of obstetrical and gynecological disorders -- Environmental toxicology; carcinogens and heavy metals -- Appendix I: Principles of prescription order writing and patient compliance -- Appendix II: Design and optimization of dosage regimens: pharmacokinetic data.
    Also available: Print – 2011
  • 2006
    Laurence L. Brunton, John S. Lazo, Keith L. Parker ... [et al.], editors.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Carol S. North, Sean H. Yutzy.
    Status: Not Checked OutLane Catalog Record
    Evolution of psychiatric diagnosis -- Mood (affective) disorders -- Schizophrenic disorders -- Panic disorder and phobias -- Posttraumatic stress disorder -- Obsessive-compulsive disorder -- Eating disorders -- Somatization disorder (hysteria) -- Antisocial personality (sociopathy) -- Borderline personality disorder -- Alcoholism -- Drug dependence -- Delirium and dementia (acute and chronic brain syndromes) -- The psychiatric evaluation.
  • 2007
    Jerri Ledford and Mary E. Tyler.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Rael Dornfest, Paul Bausch, and Tara Calishain.
    Status: Not Checked OutLane Catalog Record
    Web -- Advanced web -- News and blogs -- Extending Google -- Google maps -- Gmail -- Webmastering -- Programming Google.
  • 2012 Ovid
    editors, Matthew E. Falagas, Eleftherios Mylonakis.
    "Using the two-page, templated organization of the 5-Minute Consult series, Gorbach's 5-Minute Infectious Diseases Consult, Second Edition provides comprehensive coverage for clinicians dealing with infectious diseases. The two major sections of the book cover chief complaints and individual diseases and disorders. Additional materials include summary information about individual microorganisms as well as numerous elements related to drugs for infectious disorders. A team of international authorities provides actionable information, supported by current research and practice guidelines.Features Include: Comprehensive coverage of infectious diseases, important symptoms, microorganisms, and anti-infective drugs Coverage of emerging infectious diseases such as H1N1 flu Increased coverage of tropical diseases Two-page, tightly written chapters Updated information about management of HIV/AIDS "--Provided by publisher.
  • 2010
    [edited by] Raoul C.M. Hennekam, Ian D. Krantz, Judith E. Allanson.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    David S. Newcombe ; edited by Dwight R. Robinson.
    A brief history of gout -- The prevalence and risk factors for gout -- Purine biochemistry -- Uric acid metabolism in humans -- Clinical aspects of gout and associated disease states -- Diagnostic procedures in the management of gout -- Roentgenographic findings and musculoskeletal ultrasound -- Mechanisms of the acute attack of gout and its resolution -- Management of hyperuricemia and gout.
  • 2012 ScienceDirect
    2012 ClinicalKey
    [edited by] Robert Terkeltaub.
    Dr. Robert Terkeltaub, presents the state-of-the-art, clinically-focused coverage you need to manage these increasingly prevalent diseases. Diagnose the full range of crystal arthropathies-including pseudogout, intercritical gout, hyperuricemia, and gouty arthritis-and treat your patients effectively with discussions of recently-approved drugs like Uloric and those currently under review, such as Kristexxa and Colcryst. With coverage of the latest therapies, preventions, and imaging studies, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and crystal-induced arthropathies. Stay current on recent developments such as uricosuric therapy and inhibitor therapy; gout flare prophylaxis and colchicines; ultrasound in the diagnosis of crystal deposition diseases; imaging of gout, CPPD, and hydroxyapatitie deposition diseases; and uricase therapy of gout. Manage the full range of crystal arthropathies with 25 clinically-focused chapters on pseudogout, intercritical gout, hyperuricemia, gouty arthritis, and more. Treat your patients effectively using the latest information on drug treatments, from the recently-approved Uloric to Kristexx and Colcryst, which are still under review. The tools to you need to diagnose, treat, and manage gout and other crystal arthropathies.
  • 2006 ebrary
    Carol S. Weissert and William G. Weissert.
    Examines health care policy making from a long-term, political perspective, describing how Congress, the president, special interest groups, bureaucracy, and state governments help define health policy problems and find politically feasible solutions. The third edition of this pathbreaking book is updated to cover recent legislative efforts, including the Medicare prescription drug benefit.
  • 2006 Springer
    by Maurice Kogan, Mary Henkel and Steve Hanney.
  • 2012 Springer
    Denis J. Dupré, Terence E. Hébert, Ralf Jockers, editors.
    ER-bound steps in the biosynthesis of G protein-coupled receptors / Christian Nanoff and Michael Freissmuth -- Role of chaperones in G Protein coupled receptor signaling complex assembly / Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- GPCR oligomerization: contribution to receptor biogenesis / Kathleen Van Craenenbroeck -- The functional size of GPCRs: monomers, dimers or tetramers? / Darlaine Pétrin and Terence E. Hébert -- Regulation of post-Golgi traffic of G protein-coupled receptors / Guangyu Wu -- Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- Regulatory processes governing the cell surface expression of LH and FSH receptors / Deborah L. Segaloff -- Chaperone-mediated assembly of G protein complexes / Barry M. Willardson and Christopher M. Tracy -- Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / Jane Dingus and John D. Hildebrandt -- Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / Janet D. Robishaw -- G Protein trafficking / Philip B. Wedegaertner -- Differential assembly of GPCR signaling complexes determines signaling specificity / Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- GPCR and voltage-gated calcium channels (VGCC) signaling complexes / Christophe Altier -- Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
  • 2007 Springer
    editors, H.R. Bourne, R. Horuk, J. Kuhnke, H. Michel.
  • 2013
    Thomas D. Glenn.
    The scope and complexity of the vertebrate nervous system requires the rapid transmission of neural impulses over long distances. The myelin sheath is an evolutionary adaptation that allows axons to rapidly propagate action potentials. Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) form myelin by wrapping their cell membranes around axons to form a multilayered membranous sheath that insulates and supports axons. Voltage gated sodium channels cluster at the unmyelinated gaps between myelin segments--the nodes of Ranvier. Depolarization of the axonal membrane at the nodes allows action potentials to propagate in a saltatory manner. Diseases of myelin, including multiple sclerosis in the CNS, and Charcot-Marie-Tooth disease in the PNS, underscore its clinical importance. In this dissertation, I focus on the mechanisms controlling the initiation and maturation of myelin in the PNS, as well as the role of Schwann cells in regulating sodium channel clustering at the nodes of Ranvier. Schwann cells arise from the neural crest in a series of developmental stages and depend upon axonal signals, such as Neuregulin 1 type III (Nrg1-III), for their survival and differentiation into myelinating Schwann cells. Nrg1-III signals control almost every aspect of Schwann cell development, but it has been proposed that other signaling pathways, such as those mediated by cyclic adenosine monophosphate (cAMP), may intersect with the Nrg1 pathway to affect a Schwann cell's response to Nrg1. In Chapter 2, I describe the identification of an orphan adhesion G protein-coupled receptor (GPCR), Gpr126, that was identified in a forward genetic screen in zebrafish. Gpr126 is essential for Schwann cells to initiate myelination, and gpr126 mutant zebrafish are devoid of PNS myelin. I show that Gpr126 is required cell-autonomously in Schwann cells to initiate myelination, and that elevating cAMP by drug treatment rescues myelination in gpr126 mutants in vivo. These results provide strong evidence that Gpr126 is the receptor that activates cAMP signaling to initiate myelination in Schwann cells in vivo. In Chapter 3, I demonstrate that although Gpr126 is essential for the initiation of myelination, it is no longer required for the maturation or maintenance of the myelin sheath. Notably, although Gpr126 signaling is required for the expression of the promyelinating transcription factor Krox20 during the initiation of myelination, Gpr126 signaling is dispensable for the maintenance of Krox20 expression. I further demonstrate that expression of activated protein kinase A (PKA) in Schwann cells is sufficient to rescue myelination in gpr126 mutants in vivo, but that over-expression of Nrg1-III in neurons is not. These results show that Gpr126 has a specific function during the initiation of myelination, and suggest that Gpr126 signaling functions in parallel to Nrg1 signaling. In chapter 4, I describe a novel role for Schwann cells in inhibiting the clustering of axonal sodium channels at the internodes, thereby confining sodium channel clustering to the nodes of Ranvier. Taken together, the findings described in this dissertation identify an orphan adhesion GPCR that regulates the initiation of myelination in Schwann cells, as well as define a novel role for Schwann cells in the regulation of sodium channel clustering.
  • 2014 Ovid
    Grabb, William C.; Smith, James W.; Thorne, Charles.
    Pt. 1: Principles, techniques, and basic science -- Pt. 2: Skin and soft tissue -- Pt. 3: Congenital anomalies and pediatric plastic surgery -- Pt. 4: Head and neck -- Pt. 5: Aesthetic surgery -- Pt. 6: Breast -- Pt. 7: Body contouring -- Pt. 8: Hand -- Pt. 9: Trunk and lower extremity.
    Also available: Print – 2014
  • 2007 Ovid
    editor-in-chief, Charles H. Thorne ; editors, Robert W. Beasley ... [et al.].
    Also available: Print – 2007
  • 2009 Ovid
    editors, Berish Strauch, Luis O. Vasconez, Elizabeth J. Hall-Findlay, Bernard T. Lee.
    v. 1. Head and neck -- v. 2. Upper extremities -- v. 3. Torso, pelvis, and lower extremities.
  • 2007
    Status: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    [edited by] Andreas Adam, Adrian K. Dixon, Jonathan H. Gillard, Cornelia M. Schaefer-Prokop.
    Long recognized as the standard general reference in the field, this completely revised edition of Grainger and Allison's Diagnostic Radiology provides all the information that a trainee needs to master to successfully take their professional certification examinations as well as providing the practicing radiologist with a refresher on topics that may have been forgotten. Organized along an organ and systems basis, this resource covers all diagnostic imaging modalities in an integrated, correlative fashion and focuses on those topics that really matter to a trainee radiologist in the initial years of training. Master the field and prepare for certification or recertification with a succinct, comprehensive account of the entire spectrum of imaging modalities and their clinical applications.
  • v.1-2., 2008
    edited by Andy Adam, Adrian K. Dixon ; consulting editors, Ronald G. Grainger, David J. Allison.
    Status: Not Checked OutLane Catalog Record
  • 2013 ClinicalKey
    edited by Nyree Griffin, Lee Grant.
    Chest wall and pleura -- Mediastinum -- Pulmonary infection -- Large airway disease -- Pulmonary lobar collapse -- Pulmonary neoplasms -- High-resolution computed tomography (HRCT) -- Chest trauma -- Airspace disease -- Paediatric chest -- Miscellaneous ITU chest conditions -- Congenital heart disease (introduction) -- Non-ischaemic acquired heart disease -- Pulmonary circulation and thromboembolism -- The aorta -- Peripheral vascular disease -- Ischaemic heart disease -- Interventional vascular radiology techniques -- Oesophagus -- Stomach -- Duodenum -- Small bowel -- Colon -- Liver -- Biliary -- Pancreas -- Spleen -- Peritoneum, mesentery and omentum -- Plain abdominal radiograph -- Paediatric gastrointestinal disorders -- Kidneys -- Bladder -- Prostate -- Urethra -- Male reproductive system -- Paediatric genitourinary disorders -- Skeletal trauma -- Paediatric fractures -- Soft tissue imaging -- General characteristics of bone tumours -- Benign bone tumours -- Malignant bone tumours -- Metabolic and endocrine skeletal disease -- Joint disease -- Bone and soft tissue infection -- Congenital skeletal anomalies -- Myeloproliferative disorders -- Breast -- Gynaecology -- Intracranial tumours in adults -- Cerebrovascular disease and non-traumatic haemorrhage -- Brain infection, AIDS and demyelinating diseases -- Brain trauma, degenerative disorders and epilepsy -- Paediatric neuroradiology -- The spine -- The orbit -- Ear, nose and throat radiology -- Dental radiology -- Endocrine system -- Lymphoma -- General pearls -- Anatomy pearls -- Radiology techniques -- Pearls in musculoskeletal imaging and pathology -- Patterns of tumour spread -- TNM staging of common cancers.
  • Google Books
    by Karl Pearson.
    Also available: Print – 1911.
  • 2014
    Stephen W. Russell, David C. Morrison.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Anne M.R. Agur, Arthur F. Dalley II.
    Status: Not Checked OutLane Catalog Record
    Thorax -- Abdomen -- Pelvis and perineum -- Back -- Lower limb -- Upper limb -- Head -- Neck -- Cranial nerves.
  • 2013
    Anne M.R. Agur, Arthur F. Dalley II.
    Status: Not Checked OutLane Catalog Record
    Thorax -- Abdomen -- Pelvis and perineum -- Back -- Lower limb -- Upper limb -- Head -- Neck -- Cranial nerves.
  • 2009
    Patrick W. Tank.
    Status: Not Checked OutLane Catalog Record
    The back -- The upper limb -- The thorax -- The abdomen -- The pelvis and perineum -- The lower limb -- The head and neck.
  • 2010 Atypon
    Fabrizio De Vico Fallani and Fabio Babiloni.
  • 2016 Springer
    Rui Zeng, [editor].
    Basic knowledge of ECG -- P Wave -- P-R Interval -- QRS Complex -- ST Segment -- T Wave -- Other Common Abnormal ECGs.
  • 2011 ebrary
    Margaret A. Post.
    Organizational pathways to political incorporation : the role of coalitions -- Immigrant political power : claims-making coalitions and policy outcomes -- Research design for theory and practice -- Massachusetts and California : 2004-2007 -- Organizational analysis : process and outcomes -- Immigrant organizations and policy change : the future role of coalitions.
  • 2015 Springer
    Rebecca S. Bahn, editor.
    This indispensable volume is designed to facilitate the best possible physician?patient discussion on Graves? disease by providing the most up-to-date evidence-based information in a clinically useful and patient-centric manner. Comprehensive and covering such topics as Professionalism and the Art of Patient-centric Thyroidology, the Immunopathogenesis of Graves? Disease, and the Diagnosis and Management of Thyroid Storm, the book addresses all the important refinements in the treatment of Graves? disease in recent years. These include new indications and contraindications for antithyroid drugs, improved approaches to radioactive iodine therapy, the development of novel surgical techniques, and a better understanding of the combined use of these modalities, among other developments. Also addressed are the advances in the treatment of GO, including the use of disease activity and severity assessments to inform management decisions and the completion of the first randomized controlled therapeutic trials. Developed by a renowned group of internationally respected authorities, Graves? Disease: A Comprehensive Guide for Clinicians is a significant new reference that will be of great interest to all clinicians who treat this debilitating condition.
  • by Henry Gray ... thoroughly revised and re-edited by Warren H. Lewis; illustrated with 1247 engravings [by] H. Lewis.
    Also available: Print – 1918
  • 2015 ClinicalKey
    Richard L. Drake, Wayne Vogl, Adam W.M. Mitchell.
    Anatomy texts just don't get any better than Gray's Anatomy for Students! Now in its 3rd edition, this completely revised medical textbook continues its focus on just the core information you need for your anatomy courses, presenting everything in an easy-to-read, visually appealing format that facilitates study. Obtain reliable, accessible coverage of everything you will learn in your contemporary anatomy classes with expert knowledge from a team of authors who share a wealth of diverse teaching and clinical experience.Easily locate and remember specific structures. More than 1,000 innovative, original illustrations by renowned illustrators Richard Tibbitts and Paul Richardson capture anatomical features with unrivalled clarity.Understand the practical applications of anatomical concepts through unique coverage of surface anatomy, correlative diagnostic images, and clinical case studies.Expedite the review of basic concepts from each chapter with Conceptual Overviews.
  • 2016 ClinicalKey
    editor-in-chief, Susan Standring ; section editors, Neel Anand [and 12 others].
    Sect. 1: Cells, tissues and systems -- Sect. 2: Embryogenesis -- Sect. 3: Neuroanatomy -- Sect. 4: Head and neck -- Sect. 5: Back -- Sect. 6: Pectoral girdle and upper limb -- Sect. 7: Thorax -- Sect. 8: Abdomen and pelvis -- Sect. 9: Pelvic girdle and lower limb.
  • 2015 ClinicalKey
    Richard L. Drake, A. Wayne Vogl, and Adam W.M. Mitchell.
    Gray's Atlas of Anatomy, the companion resource to the popular Gray's Anatomy for Students, presents a vivid, visual depiction of anatomical structures. Newly updated with a wealth of material to facilitate study, this medical textbook demonstrates the correlation of structures with appropriate clinical images and surface anatomy - essential for proper identification in the dissection lab and successful preparation for course exams. Clinically focused, consistently and clearly illustrated throughout, and logically organized, Gray's Atlas of Anatomy makes it easier than ever to master the essential anatomy knowledge you need! Build on your existing anatomy knowledge with structures presented from a superficial to deep orientation, representing a logical progression through the body.Identify the various anatomical structures of the body and better understand their relationships to each other with the visual guidance of nearly 1,000 exquisitely illustrated anatomical figures.Visualize the clinical correlation between anatomical structures and surface landmarks with surface anatomy photographs overlaid with anatomical drawings.Recognize anatomical structures as they present in practice through more than 270 clinical images - including laparoscopic, radiologic, surgical, ophthalmoscopic, otoscopic, and other clinical views - placed adjacent to anatomic artwork for side-by-side comparison.
  • 2012 ClinicalKey
    by Richard Drake, A. Wayne Vogl, Adam W.M. Mitchell.
    Gray's Basic Anatomy equips you with all the essential anatomy information you need to know, in half the length of the original Gray's Anatomy for Students! This new medical textbook lets you study efficiently while being confident in your mastery of the most important anatomical concepts. See the clinical implications with ""Clinical Apps, "" ""Imaging Apps, "" and surface anatomy boxes throughout. Get a clear picture with carefully selected illustrations that are easy to learn from, modern in design, and concisely labeled. Access a wealth of ancillary mate.
  • 2011 ClinicalKey
    editor, Elliott L. Mancall ; associate editor, David G. Brock.
    Gray's Clinical Neuroanatomy focuses on how knowing functional neuroanatomy is essential for a solid neurologic background for patient care in neurology. Elliot Mancall, David Brock, Susan Standring and Alan Crossman present the authoritative guidance of Gray's Anatomy along with 100 clinical cases to highlight the relevance of anatomical knowledge in this body area and illustrate the principles of localization. Master complex, detailed, and difficult areas of anatomy with confidence. View illustrations from Gray's Anatomy and radiographs that depict this body area in thorough anatomical detail. Apply the principles of localization thanks to 100 brief case studies that highlight key clinical conditions. Tap into the anatomical authority of Gray's Anatomy for high quality information from a name you trust. Presents the guidance and expertise of a high profile team of authors and top clinical and academic contributors.
  • 2012 ClinicalKey
    Marios Loukas, Brion Benninger, R. Shane Tubbs.
    Gray's Clinical Photographic Dissector of the Human Body, by Drs. Marios Loukas, Brion Benninger, and R. Shane Tubbs, helps you take a clinical approach to the study of anatomy. This unique dissection guide uses full-color photographs rather than anatomical drawings to orient you more quickly in the lab, and points out the clinical significance of each structure and every dissection you make. You will also find valuable information on several emergency procedures used today to further reinforce the clinical correlations.
  • 2006
    David S. Barnes.
    Status: Not Checked OutLane Catalog Record
    Introduction -- "Not everything that stinks kills" : odors and germs on the streets of Paris, 1880 -- The sanitarian's legacy, or how health became public -- Taxonomies of transmission : local etiologies and the equivocal triumph of germ theory -- Putting germ theory into practice -- Toward a cleaner and healthier republic -- Odors and "infection," 1880 and beyond -- The legacy of the twentieth century.
  • 2007 NCI
    edited by Allan Best ... [et al.].
  • 2012 ebrary
    by Jacques Jouanna ; edited with a preface by Philip van der Eijk ; translated by Neil Allies.
    This volume makes available for the first time in English translation a selection of Jacques Jouanna's papers on medicine in the Graeco-Roman world. The papers cover more than thirty years of Jouanna's scholarship and range from the early beginnings of Greek medicine to late antiquity. Part One studies the ways in which Greek medicine is related to its historical and cultural background (politics, rhetoric, drama, religion). Part Two studies a number of salient features of Hippocratic medicine, such as dietetics, theories of health and disease and concepts of psychosomatic interaction, in relation to Greek philosophical thought. Part Three studies the reception of Hippocratic medicine, especially medical ethics and the theory of the four humours, in Galen and in late antiquity.
  • 2006 Wiley
    edited by Martin Chalfie, Steven R. Kain.
    "Green fluorescent protein (GFP), a biological marker cloned from jellyfish, has emerged from virtual obscurity to the forefront of biomolecular research in just a few years. GFP and related fluorescent proteins (FPs) have been intensely studied - the subjects of hundreds of in vivo projects worldwide. These studies have resulted in new applications and published articles, emerging at a breathtaking rate. The success of FPs and their many uses promise to make them some of the most powerful tools in biotechnology, pharmaceutical science, and molecular and cellular biology."
    Also available: Print – 2006
  • v. 1-2, 2008.
    edited by Seth Love, David N. Louis, David W. Ellison.
    Status: Not Checked OutLane Catalog Record
  • 2006
    editors, Michael W. Mulholland ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2011 Ovid
    editors, Michael W. Mulholland ... [et al.] ; illustrations by Holly R. Fischer.
    "The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images"--Provided by publisher.
  • 2014 Ovid
    William M. Klykylo ... [et al].
    The ideal quick reference for the busy mental health clinician seeing younger patients, the Fifth Edition of Green's Child and Adolescent Clinical Psychopathology has been fully revised by a new team of authors active in clinical practice and resident education. A trusted reference in the field, Green's continues to provide practical and balanced information on the full range of medications used to treat mental health disorders in children and adolescents. ... NEW to the Fifth Edition: Increased focus on medication effects and cost-effectiveness. New information on cardiac function and risk factors in patients taking stimulants. Long-term suicide risks associated with SSRIs. Longer term outcomes of major depression treatment. Use of anticonvulsant medications in patients with bipolar disorder. Weight gain in patients taking antipsychotics.
  • 2017 ClinicalKey
    [edited by] Scott W. Wolfe, Robert N. Hotchkiss, William C. Pederson, Scott H. Kozin, Mark S. Cohen.
  • 2011 ClinicalKey
    editor-in-chief, Scott W. Wolfe ; editors, Robert N. Hotchkiss, William C. Pederson, Scott H. Kozin.
    Also available: Print – v. 1-2, 2011.
  • 2015 ClinicalKey
    [edited by] Gregory A. Mencio, Marc F. Swiontkowski.
    Obtain the best outcomes from the latest techniques with help from a "who's who" of pediatric orthopaedic trauma experts! Considered as the "go-to" reference for orthopaedic trauma surgeons and pediatric orthopaedic trauma surgeons, Green's Skeletal Trauma in Children presents practical, focused guidance on managing traumatic musculoskeletal injuries in children and adolescents. It emphasizes the unique aspects of children's fractures in terms of epidemiology, mechanisms, management, and the challenges of treating the skeletally immature patient. State-of-the-art coverage includes crucial chapters on skeletal trauma related to child abuse, anesthesia and analgesia, management of children's fractures, and outcome measures and rehabilitation.
  • 2011 (9th ed.). AccessMedicine
    Gardner, David G.; Greenspan, Francis S.; Shoback, Dolores M.
    Also available: Print – 2007-<2011>
  • 2009
    J. William Worden.
    Status: Not Checked OutLane Catalog Record
    Attachment, loss, and the experience of grief -- Understanding the mourning process -- The mourning process: mediators of mourning -- Grief counseling: facilitating uncomplicated grief -- Abnormal grief reactions: complicated mourning -- Grief therapy: resolving complicated mourning -- Grieving special types of losses -- Grief and family systems -- The counselor's own grief -- Training for grief counseling.
  • 2011 ClinicalKey
    Stephen W. Moore ; with assistance of Jo A. Griffith.
    Help your patients understand what their illness is and how it will affect their regular routine.
  • 2011 AccessMedicine
    David A. Morton, K. Bo Foreman, Kurt H. Albertine.
    Back -- Thorax -- Abdomen, Pelvis and Perineum -- Head -- Neck -- Upper Limb -- Lower Limb.
  • 2008
    Kyung Won Chung, Harold M. Chung.
    Status: Not Checked OutLane Catalog Record
    Presents detailed information and diagrams about human anatomy, with review questions and answers, and a comprehensive examination.
  • 2007
    N. Anthony Moore, William A. Roy.
    Status: Not Checked OutLane Catalog Record
  • 2010
    N. Anthony Moore, William A. Roy.
    Status: Not Checked OutLane Catalog Record
    Back -- Thorax -- Abdomen -- Pelvis and perineum -- Lower extremity -- Upper extremity -- Neck -- Head.
  • 2005 Springer
    P. Reuter.
    Deutsch-Englisch -- Englisch-Deutsch.
  • Ovid
    editor, Mauro Moscucci.
    "Grossman & Baim's Cardiac Catheterization, Angiography, and Intervention, 8e is the premier reference on cardiac catheterization and appeals to seasoned practitioner, residents and cardiology fellows. This title reflects the rapid evolution and growing clinical use of interventional techniques. Premier reference on cardiac catheterization appeals to seasoned practitioner, residents and cardiology fellows. Reflects rapid evolution and growing clinical use of interventional techniques. Eleven new chapters, including: Integrated Imaging Modalities in the Cardiac Catheterization Lab; Radial Artery Approach; Coronary Artery Anomalies; Interventions for Acute Myocardial Infarction; Interventions with Cell Therapies; and Aortic Endovascular Grafting Over 20 procedural videos online"--Provided by publisher.
  • 2006 Ovid
    editor, Donald S. Baim.
    Also available: Print – 2006
  • v.1-4, 2014
    edited by Adele E. Clarke and Kathy Charmaz.
    Status: Not Checked OutLane Catalog Record
    v. 1. History, essential and debates in grounded theory -- v. 2. Grounded theory in disciplines and research -- v. 3. Grounded theory exemplars across disciplines -- v. 4. Situational analysis : essentials and exemplars.
  • 2008 Springer
    Steven Tracy, M. Steven Oberste, Kristen M. Drescher, editors.
    Coxsackie B viruses: an introduction / B.W. Mahy -- Coxsackieviruses and quasispecies theory: evolution of enteroviruses / E. Domingo ... [et al.] -- Comparative genomics of the coxsackie B viruses and related enteroviruses / M.S. Oberste -- Group B coxsackievirus virulence / S. Tracy and C. Gauntt -- The coxsackievirus and adenovirus receptor / P. Freimuth, L. Philipson and S.D. Carson -- Coxsackievirus B RNA replication: lessons from poliovirus / P. Sean and B.L. Semler -- CVB translation: lessons from the polioviruses / J.M. Bonderoff and R.E. Lloyd -- Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis / R. Feuer and J.L. Whitton -- The impact of CVB3 infection on host cell biology / D. Marchant ... [et al.] -- Host immune responses to coxsackievirus B3 / S. Huber -- Pediatric group B coxsackievirus infections / J.R. Romero -- CVB-induced pancreatitis and alterations in gene expression / A.I. Ramsingh -- The CVB and etiology of type 1 diabetes / K.M. Drescher and S.M. Tracy -- Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and dilated cardiomyopathy / N.M. Chapman and K.S. Kim -- Autoimmunity in coxsackievirus infection / N.R. Rose -- CVB infection and mechanisms of viral cardiomyopathy / K.U. Knowlton.
    Also available: Print – 2008
  • 2011 Springer
    Gary E. Marchant, Braden R. Allenby, Joseph R. Herkert, editors ; foreword by Peter A. French.
    At the same time that the pace of science and technology has greatly accelerated in recent decades, our legal and ethical oversight mechanisms have become bogged down and slower. This book addresses the growing gap between the pace of science and technology and the lagging responsiveness of legal and ethical oversight society relies on to govern emerging technologies. Whether it be biotechnology, genetic testing, nanotechnology, synthetic biology, computer privacy, autonomous robotics, or any of the other many emerging technologies, new approaches are needed to ensure appropriate and timely regulatory responses. This book documents the problem and offers a toolbox of potential regulatory and governance approaches that might be used to ensure more responsive oversight.
  • 2016 Springer
    Behrooz A. Akbarnia, Muharrem Yazici, George H. Thompson, editors.
    Embryology and Anatomy -- Normal Growth of the Spine and Thorax -- Biomechanics in the Growing Spine -- Genetics -- New Classification System -- Clinical Evaluation -- Normal Lung growth and Thoracic Insufficiency Syndrome -- Imaging of The Growing Spine -- Back Pain in Children -- Pediatric Spinal Infections -- PostOp Infections -- Management of Spine Tumors in Young Children -- Intraspinal Pathology -- Pediatric Spine Trauma -- Sports and Sports Related Injuries -- Spinal Deformity in Metabolic Disorders -- Spinal Manifestations of the Skeletal Dysplasias -- Syndromic Spinal Deformities in the Growing Child -- Idiopathic Scoliosis: Infantile and Juvenile -- Congenital Scoliosis -- Treatment of Spinal Deformity in Cerebral Palsy -- Myelodsplasia -- Spinal Dysraphism -- Other Neuromuscular Diseases -- Neurofibromatosis -- Sagittal Plane Alignment and Deformities -- Spondylolisthesis -- Casting for Early Onset Scoliosis -- Orthotic Management for (I-EOS) Infantile and Juvenile Scoliosis -- Halo-Gravity Traction -- Crankshaft Phenomena Following Spinal Fusion in the Growing Child -- Convex Growth Arrest for Congenital Scoliosis -- Surgical management of Kyphosis in Myelomeningocele -- Hemivertebrectomy -- Vertebral Osteotomy -- Vertebral Resection -- Growing Rods -- VEPTR Expansion Thoracoplasty -- Revision Spine Surgery in the Growing Child -- Anesthetic Considerations In the growing children and repetitive anesthesia -- Intraoperative Neurophysiological Monitoring During Corrective Spine Surgery in the Growing Child -- Nursing Care -- Long- Term Effects of Instrumented Fusion in Growing Children -- Outcomes in Children with Early Onset Scoliosis -- Current Basic Science Research in Growth Modulation and Future Outlook -- Spinal External Fixation -- Growth Guided Instrumentation -- Hybrid Distraction-Based Growing Rods.
  • 2011 Springer
    Behrooz A. Akbarnia, Muharrem Yazici, George H. Thompson (eds.).
    The treatment of such conditions is often challenging due to the age of the patient and the progressive nature of the deformity. There also may be associated problems such as congenital anomalies, respiratory insufficiency, and neurological problems. Depending on the etiology of the deformity, these children are often cared for by multiple specialists including pediatricians, pediatric orthopaedists or orthopaedic spine surgeons, neurologists, pediatric surgeons, pediatric neurosurgeons, oncologists, and/or pulmonologists. Health professionals in all of the mentioned disciplines are involved in the management of these patients, which is why compiling a comprehensive textbook that is not limited to orthopedic specialists is essential. This textbook will effectively help to standardize the care of these patients. Furthermore, other professionals such as nurses, physical therapists and healthcare professionals in training are usually not familiar with these conditions and are in need of a reference book to consult when caring for children with spinal deformities.
  • 2014 CRCnetBASE
    Daniel Mirman.
    "Accessible to quantitative psychology researchers, this book introduces growth curve analysis (GCA) methods for applications in the behavioral sciences. It introduces the challenges involved with this type of data, discusses the basics of GCA, and explains how the methods can be used to analyze the data. The book takes a very practical approach, emphasizing visualization and keeping mathematical details to a minimum. It includes many real data examples from cognitive science and social psychology and integrates R code for the implementation of the methods"-- Provided by publisher. "This book is intended to be a practical, easy-to-understand guide to carrying out growth curve analysis (multilevel regression) of time course or longitudinal data in the behavioral sciences, particularly cognitive science, cognitive neuroscience, and psychology. Multilevel regression is becoming a more and more prominent statistical tool in the behavioral sciences and it is especially useful for time course data, so many researchers know they should use it, but they do not know how to use it. In addition, analysis of individual differences (developmental, neuropsychological, etc.) is an important subject of behavioral science research but many researchers don't know how to implement analysis methods that would help them quantify individual differences. Multilevel regression provides a statistical framework for quantifying and analyzing individual differences in the context of a model of the overall group effects. There are several excellent, detailed textbooks on multilevel regression, but I believe that many behavioral scientists have neither the time nor the inclination to work through those texts. If you are one of these scientists -- if you have time course data and want to use growth curve analysis, but don't know how -- then this book is for you. I have tried to avoid statistical theory and technical jargon in favor of focusing on the concrete issue of applying growth curve analysis to behavioral science data and individual differences."-- Preface.
  • 2006 Springer
    volume editors, U. Kües, R. Fischer.
  • 2016 Springer
    Jason White, Gayle Smith, editors.
    This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.
    Also available: Print – 2016
  • 2011 ScienceDirect
    G.V. Sherbet.
    Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes. Aids the development of therapeutic treatments for cancer. Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research.
  • 2005 Karger
    volume editors, Jens Otto Lunde Jørgensen, Jens Sandahl Christiansen.
    Clinical aspects of growth hormone deficiency in adults: an overview / Jørgensen, J.O.L., Christiansen, J.S. -- Epidemiology of adult growth hormone deficiency: prevalence, incidence, mortality and morbidity / Erfurth, E.M. -- Hypopituitarism following traumatic brain injury / Popovic, V. ... [et al.] -- IGF-I measurements: epidemiological and clinical aspects / Juul, A. -- Diagnosis of growth hormone deficiency / Fisker, S., Andersen, M., Orskov, H. -- Clinical monitoring of growth hormone replacement in adults / Gibney, J., Johannsson, G. -- Consequences of growth hormone deficiency for intermediary metabolism and effects of replacement / Norrelund, H. -- Skeletal and cardiac muscle in adults with growth hormone deficiency / Cuneo, R.C., Wallace, J.D. -- Bone metabolism and growth hormone deficiency: experimental and clinical aspects / Ueland, T., Bollerslev, J. -- Growth hormone and fluid homeostasis / Moller, J. -- Growth hormone and body composition / Mersebach, H., Feldt-Rasmussen, U. -- Effects of growth hormone deficiency and growth hormone treatment on quality of life in growth hormone-deficient adults / Arwert, L.I., Berend Deijen, J., Drent, M.L. -- Safety aspects of growth hormone replacement / Waterhouse, M., Monson, J.P.
    Also available: Print – 2005
  • 2011 Springer
    Ken Ho, editor.
    Growth Hormone Receptor in Growth -- Ghrelin in the Regulation of GH Secretion and Other Pituitary Hormones -- Growth Hormone Pulsatility and its Impact on Growth and Metabolism in Humans -- Metabolic Actions of Growth Hormone -- Molecular Genetics of Congenital Growth Hormone Deficiency -- Structural Abnormalities in Congenital Growth Hormone Deficiency -- Genetic Causes of Familial Pituitary Adenomas -- The Epidemiology of Growth Hormone Deficiency -- Diagnosis of Growth Hormone Deficiency in Adults -- Transition from Puberty to Adulthood -- Issues in Long-Term Management of Adults with Growth Hormone Deficiency -- Quality of Life in Acromegaly and Growth Hormone Deficiency -- The Value of GH and IGF-I Measurements in the Management of Acromegaly -- The Role of Somatostatin Analogues in Treatment of Acromegaly -- The Role of External Beam Radiation Therapy and Stereotactic Radiosurgery in Acromegaly -- Mortality and Morbidity in Acromegaly: Impact of Disease Control -- GHR Antagonist: Efficacy and Safety -- Long-Acting Growth Hormone Analogues -- Growth Hormone Supplementation in the Elderly -- Growth Hormone in Sports: Is There Evidence of Benefit?
  • 2008 Springer
    Alan E. Oestreich ; with illustrations by Tamar Kahane Oestreich.
  • Google Books
    von P. Lesshaft.
    Also available: Print – v. 1, 1892.
  • Google Books
    Ostwald, Wolfgang.
    Also available: Print – v. 1, 1919.
    Also available: Print – v. 2, 1919.
  • Google Books
    Steiner, Isidor.
    Also available: Print – 1886.
  • Google Books
    Steiner, Isidor.
    Also available: Print – 1883.
  • Google Books
    Steiner, Isidor.
    Also available: Print – 1892.
  • Google Books
    Ranke, Johannes.
    Also available: Print – 1868.
  • 2005 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2005
  • 2005 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2005
  • 2013 ScienceDirect
    Arya Nielsen ; foreword by Ted J. Kaptchuk.
  • 2013 Springer Protocols
    edited by Thomas Krieg, Robert Lukowski.
    NO/cGMP : the past, the present, and the future / Michael Russwurm [and 3 others] -- cGMP-dependent protein kinases (cGK) / Franz Hofmann and Jörg W. Wegener -- Enzyme assays for cGMP hydrolyzing phosphodiesterases / Sergei D. Rybalkin, Thomas R. Hinds, and Joseph A. Beavo -- Radioimmunoassay for the quantification of cGMP levels in cells and tissues / Ronald Jäger [and 5 others] -- Hyperspectral imaging of FRET-based cGMP probes / Thomas C. Rich [and 3 others] -- Visualization of cGMP with cGi biosensors / Martin Thunemann [and 4 others] -- Advances and techniques to measure cGMP in intact cardiomyocytes / Konrad R. Götz and Viacheslav O. Nikolaev -- Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells / Kara F. Held and Wolfgang R. Dostmann -- Methods for identification of cGKI substrates / Katharina Salb and Jens Schlossmann -- Approaches for monitoring PKG1[alpha] oxidative activation / Joseph Robert Burgoyne and Philip Eaton -- Analysis of cGMP signaling in adipocytes / Katja Jennissen [and 4 others] -- A genetic strategy for the analysis of individual axon morphologies in cGMP signalling mutant mice / Hannes Schmidt, Gohar Ter-Avetisyan, and Fritz G. Rathjen -- Receptor binding assay for NO-independent activators of soluble guanylate cyclase / Peter M. Schmidt and Johannes-Peter Stasch -- Direct intrathecal drug delivery in mice for detecting in vivo effects of cGMP on pain processing / Ruirui Lu and Achim Schmidtko -- The Geisler method : tracing activity-dependent cGMP plasticity changes upon double detection of mRNA and protein on brain slices / Wibke Singer, Hyun-Soon Geisler, and Marlies Knipper -- Detection of cGMP in the degenerating retina / Stylianos Michalakis [and 3 others].
  • 2014 Springer
    Francesco Biggi.
    1 Il fratturato, il polifratturato e il politraumatizzato -- 2 Le Fratture e il meccanismo di guarigione -- 3 Le fratture esposte -- 4 Il rischio tromboembolico e la sua prevenzione -- 5 Rischio infettivo: prevenzione e trattamento -- 6 Fratture vertebrali -- 7 Fratture e lussazioni della spalla -- 8 Fratture dell?omero diafisario e distale -- 9 Lussazioni e fratture (olecrano e capitello) del gomito -- 10 Fratture dell?avambraccio -- 11 Le fratture distali del radio -- 12 Fratture e lussazioni del carpo -- 13 Fratture e lussazioni della mano -- 14 Traumi della pelvi -- 15 Fratture e lussazioni dell?anca -- 16 Fratture del femore -- 17 Fratture e lussazioni del ginocchio -- 18 Fratture della tibia -- 19 Fratture malleolari -- 20 Fratture e lussazioni del piede -- 21 Fratture in età pediatrica -- 22 Fratture peri-protesiche -- 23 Fratture patologiche.
  • 2012 Cambridge
    edited by D. Micah Hester, Toby Schonfeld.
  • 2005 FDA
    I. Introduction -- A. Background -- B. Scope of the Guidance -- II. Safety Specification -- A. Elements of the Specification -- 1. Nonclinical -- 2. Clinical -- B. Summary -- III. Pharmacovigilance Plan -- A. Structure of the Pharmacovigilance Plan -- 1. Summary of Ongoing Safety Issues -- 2. Routine Pharmacovigilance Practices -- 3. Action Plan for Safety Issues -- 4. Summary of Actions To Be Completed, Including Milestones -- B. Pharmacovigilance Methods -- IV. References -- Annex - Pharmacovigilance Methods.
  • 2005 FDA
    I. Introduction -- II. Background -- A. PDUFA III'S Risk Management Guidance Goal -- B. Overview of the Risk Management Guidances -- III. The Role of Pharmacovigilance and Pharmacoepidemiology in Risk Management -- IV. Identifying and Describing Safety Signals: From Case Reports to Case Series -- A. Good Reporting Practice -- B. Characteristics of a Good Case Report -- C. Developing a Case Series -- D. Summary Descriptive Analysis of a Case Series -- E. Use of Data Mining to Identify Product-Event Combinations -- F. Safety Signals that may Warrant Further Investigation -- G. Putting the Signal into Context: Calculating Reporting Rates vs. Incidence Rates -- V. Beyond Case Review: Investigating a Signal Through Observational Studies -- A. Pharmacoepidemiologic Studies -- B. Registries -- C. Surveys -- VI. Interpreting Safety Signals: From Signal to Potential Safety Risk -- VII. Beyond Routine Pharmacovigilance: Developing a Pharmacovigilance Plan.
  • 2012 ScienceDirect
    edited by Ira O. Daar.
    Regulation of tumor initiation and metastatic progression by eph receptor tyrosine kinases / Jin Chen -- Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis / Ombretta Salvucci, Giovanna Tosato -- Semaphorin signals tweaking the tumor microenvironment / Claudia Muratori, Luca Tamagnone -- Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors / Christian Gespach -- Roundabout way to cancer / Mimmi S. Ballard, Lindsay Hinck -- Role of the VEGF/VEGFR axis in cancer biology and therapy.
  • 2010
    edited by Jeannette Capella, Steven J. Kasten, Susan Steinemann, Laura Torbeck.
    Status: Not Checked OutLane Catalog Record
    "The Educational Research Committee of the Association of Surgical Education (ASE) ... embarked upon the creation of this entirely new "Guide". It is designed to meet the needs of those who work among surgeons and surgical trainees, who embrace the scientific method in their quest to improve the education process"-- Preface.
  • NAP
    Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.
    The changes and new material in this seventh edition incorporate recent research on commonly used species, including farm animals in keeping with the belief that the Guide is subject to modification with changing conditions and new information. Also covers institutional policies and responsibilities, animal environment, husbandry, and management, veterinary care, and physical plant.
    Also available: Print – 1996
  • 2011 ebrary
    Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies.
    "Incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. Provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates."--Publisher's description (excerpt).
  • 2010 Springer
    Scott H. Kollins, Elizabeth P. Sparrow ; edited by C. Keith Conners.
  • 2010 Springer
    Eduard Vieta.
    Introduction -- Global assessment scales -- Detection of bipolar I -- Detection of bipolar II -- Assessment of depression in bipolar disorder -- Assessment of mania in bipolar disorder -- Assessment of hypomania -- Health-related quality of life assessment in bipolar disorder -- Assessment of pediatric bipolar disorder -- Assessment of comorbidities -- Assessment of functioning -- Assessment of suicidality.
  • 2014 Springer
    George Alexopoulos, Siegfried Kasper, Hans-Jurgen Moller, Carmen Moreno.
    This concise guide provides psychiatrists (including trainees) and general practitioners with a comprehensive overview of the most clinically relevant assessment scales and tools in order to assist with and enhance diagnostic outcomes in depression. Depression is one of the most common mood disorders across the globe, with a lifetime prevalence across all people of 8-10%. Despite being relatively common, depression remains severely underdiagnosed across all age groups and nationalities.
  • 2014 Springer
    Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Maria Joao Forjaz, Kallol Ray Chaudhuri.
    This Guide assesses the key clinimetric attributes in the assessment of Parkinson's Disease (PD), with the intention to offer rapid and pragmatic information on the most relevant scales used in PD. Parkinson?s disease affects approximately 4 million people globally and is most commonly seen in people over the age of 50. The disease is a progressive disorder of the nervous system, and presents a number of movement and cognitive symptoms, thereby greatly affecting a patients quality of life. The use of scales for assessment in neurological disorders such as PD arises from the need to quantify disorders and states (such constructs as disability, symptoms, quality of life). Assessment scales are often categorised into two categories: generic (i.e. those scales usable in any health condition), and specific (i.e. scales developed for exclusive use in PD). They can have a variety of components: single-item and multi-item or composite scale; unidimensional and multidimensional; and as disease-centered and patient-centered measures. The creation and validation of scales is complex, with scales undergoing numerous studies to assess criteria such as acceptability, reliability, and responsiveness. In the process of validation of a scale the following attributes should be tested to ascertain whether a scale is an effective instrument of measurement.
  • 2012 Springer
    Richard Keefe, editors.
    Symptom rating scales in schizophrenia -- Depression and suicidality -- Cognition -- Functional outcomes assessment scales -- Quality of life measurements in a person with schizophrenia -- Antipsychotic side-effect rating scales in schizophrenia -- Assessment scales for insight -- Assessing adherence to antipsychotic medications -- Clinical assessment scales in substance use disorders -- Medical comorbidities.
  • 2014 STAT!Ref, Limited to 7 simultaneous users
    Larry D. Purnell.
    Transcultural diversity and health care -- The Purnell model for cultural competence -- Barriers to culturally competent health care -- People of African American heritage -- People of American Indian/Alaskan Native heritage -- The Amish -- People of Appalachian heritage -- People of Arab heritage -- People of Chinese heritage -- People of Cuban heritage -- People of European American heritage -- People of Filipino heritage -- People of German heritage -- People of Guatemalan heritage -- People of Haitian heritage -- People of Hindu heritage -- People of Hmong heritage -- People of Iranian heritage -- People of Japanese heritage -- People of Jewish heritage -- People of Korean heritage -- People of Mexican heritage -- People of Polish heritage -- People of Puerto Rican heritage -- People of Russian heritage -- People of Somali heritage -- People of Thai heritage -- People of Turkish heritage -- People of Vietnamese heritage.
  • 2012 Springer
    Otto O. Yang.
    Overview: overall goals when writing grant applications -- Organization and use of this guide -- Preparing to write -- Types of NIH grants -- Anatomy of the NIH grant application -- Starting to write: planning the aims and overcoming writer's block -- Organization and writing style -- Figures and tables -- Specific aims -- Research strategy: significance -- Research strategy: innovation -- Research strategy: approach -- Bibliography and references cited -- Use of appendices -- Collaborators and consultants -- Training and career development grants -- Administrative sections and submission process -- Scoring process -- Resubmitting an application -- Non-NIH grants -- Conclusions.
  • 2009 Springer
    by Mavis Tsai. Robert J. Kohlenberg, Jonathan W. Kanter, Barbara Kohlenberg, William C. Follette, Glenn M. Callaghan.
    1. What is functional analytic psychotherapy? -- 2. Lines of evidence in support of FAP -- 3. Assessment and case conceptualization -- 4. Therapeutic technique: the five rules -- 5. Self and mindfulness -- 6. Intimacy -- 7. The course of therapy: beginning, middle and end phases of FAP -- 8. Supervision and therapist self-development -- 9. Values in therapy and green FAP -- Appendices -- Index.
  • 2016 Springer
    Albert J. Bredenoord, André Smout, Jan Tack.
    Functional Anatomy and Physiology -- Diagnostic Techniques -- Principles of Drug Treatment -- The Esophagus -- The Stomach -- The Small Intestine -- The Colon -- Anorectum -- The Biliary Tract.
  • 2009
    edited by Wendy R. Uhlmann, Jane L. Schuette, Beverly M. Yashar.
    Status: Not Checked OutLane Catalog Record
    The practice of genetic counseling / Ann P. Walker -- The ultimate genetic tool : the family history / Jane L. Schuette and Robin L. Bennett -- Interviewing : beginning to see each other / Kathryn Spitzer Kim -- Thinking it all through : case preparation and management / Wendy R. Uhlmann -- Psychosocial counseling / Luba Djurdjinovic -- Patient education / Ann C.M. Smith and Toni I. Pollin -- Risk communication and decision making / Bonnie Jeanne Baty -- The medical genetics evaluation / Elizabeth M. Petty -- Understanding genetic testing / W. Andrew Faucett and Patricia A. Ward -- Medical documentation / Debra Lochner Doyle -- Multicultural counseling / Gottfried Oosterwal -- Ethical and legal issues / Susan Schmerler -- Student supervision : strategies for providing direction, guidance, and support / Patricia McCarthy Veach and Bonnie S. LeRoy -- Genetic counseling research : understanding the basics / Beverly M. Yashar -- Professional identity and development / Elizabeth A. Gettig and Karen Greendale -- Genetic counselors as educators / Debra L. Collins and Joseph D. McInerney -- Evolving roles, expanding opportunities / Elizabeth A. Balkite and Maureen E. Smith -- Putting it all together : three case examples / Jane L. Schuette ... [et al.].
  • 2009
    Status: Not Checked OutLane Catalog Record
    Contents: Module 1: Water -- Module 2: Cleaning and Disinfection of Facilities
  • 2014 ScienceDirect
    edited by B. Anne Croy, Aureo T. Yamada, Francesco J. DeMayo, S. Lee Adamson.
    The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy.
  • 2006 ebrary
    Brian R. Hunt, Ronald L. Lipsman, Jonathan M. Rosenberg, with Kevin R. Coombes, John E. Osborn, and Garrett J. Stuck.
    Also available: Print – 2006
  • 2007 CRCnetBASE
    Andy H. Register.
  • Andy H. Register.
  • v. 1-2, 1965-69.
    prepared by the Program Area Committee on Medical Care Administration, American Public Health Association.
    Status: Not Checked OutLane Catalog Record
    v. 1. Concepts and principles.--v. 2. Medical care appraisal.
  • 2006 CRCnetBASE
    edited by Stephen P. Denyer, Rosamund M. Baird.
  • ScienceDirect
    edited by Shelby L. Berger, Alan R. Kimmel.
    Also available: Print – 1987
  • 2013 Springer
    Maria Albina Galli, Gian Battista Danzi.
    Electrocardiography has an ever-expanding role in pediatric cardiology evaluation. The specific competencies required for its optimal use in this setting, however, generally lie beyond the expertise of cardiologists used to dealing with adults. This guide - the product of extensive practical experience in the field of pediatric cardiology - proposes a very simple method for reading neonatal and pediatric ECGs that is based on the application of straightforward criteria and permits the immediate recognition of normal and pathological patterns. The first part of the guide presents and describes this methodology and the parameters of normal pediatric ECGs, while the second part focuses on specific pediatric anomalies. More than 150 ECGs displaying both normal and pathologic findings are included, all of which have been collected from clinical practice and analyzed using the proposed method. This book will be an invaluable reference tool for all cardiologists who deal with newborns and children.
  • 2007 Ovid
    [edited by] C. Edward Coffey, Thomas W. McAllister, Jonathan M. Silver.
    Apathy and related disorders of diminished motivation -- Delirium -- Cognitive impairment -- Global cognitive impairment : the dementias -- Disturbances of mood, affect, and emotion -- Anxiety -- Psychosis in neuropsychiatric disorders -- Nonepileptic seizures -- Parkinsonian movement disorders -- Hyperkinetic movement disorders -- Changes in personality -- Pain -- Sleep disorders -- Unexplained neuropsychiatric symptoms -- Intellectual disabilities of developmental onset -- Agitation and aggression -- Forensic neuropsychiatry -- Rational approach to brain imaging and electrophysiology.
  • 2011 CRCnetBASE
    by George A. Bray.
    Origins of obesity in the scientific era : 1500 AD to the present -- Definitions, measurement, and prevalence -- Genetic, metabolic, and social origins of obesity -- Effects of obesity on health and metabolism -- Prevention, evaluation, and introduction to treatment -- Lifestyle, diet, & exercise : cognitive solutions -- Medications for obesity -- Surgery for obesity -- Post-script : obesity in the twenty first century.
  • 2011 Springer
    Prasad P. Godbole, Martin A. Koyle, Duncan T. Wilcox (Editors).
    Urinary tract infection: USA -- Urinary tract infection: United Kingdom -- Urinary tract infection: Europe -- Urinary tract infection: Australasia -- Abnormalities of the scrotum -- Disorders of male external genitalia: problems of the penis and foreskin -- Disorders of male external genitalia: hypospadias, epispadias, concealed penis, and urethral disorders -- Disorders of male external genitalia: undescended testis -- Disorders of male external genitalia: circumcision -- Disorders of the female external genitalia -- Disorders of elimination: voiding dysfunction -- Disorders of elimination: nocturnal enuresis -- Disorders of elimination: constipation -- Hematuria and proteinuria -- Abdominal pain: urological aspects -- External angular dermoid and pilomatrixoma -- Neck swellings/lumps: midline neck swellings -- Neck swellings/lumps: lateral neck lumps -- Neck swellings/lumps: torticollis -- Umbilical disorders -- Surgical aspects of abdominal pain -- Approach to abdominal masses -- Gastro-esophageal reflux disease -- Rectal bleeding -- Intestinal obstruction -- Unique considerations in the neonate and infant: bile-stained vomiting in the neonate -- Unique considerations in the neonate and infant: pyloric stenosis -- Unique considerations in the neonate and infant: intussusception -- Hemangioma and lymphangioma.
  • 2009 ScienceDirect
    edited by Richard R. Burgess, Murray P. Deutscher.
    Also available: Print – 2009
  • 2009 Springer
    Joseph Palombo, Harold K. Bendicsen, Barry J. Koch.
    Sigmund Freud (1856-1939) , publishing era (1888-1950) -- Ego psychological theories (1894-1970), publishing era (1917-1966) -- Anna Freud (1895-1982), publishing era (1922-1982) -- Rene Spitz (1887-1974), publishing era (1945-1974) -- Peter Blos (1904-1997), publishing era (1941-1998) -- Greenspan (1941-), publishing era, 1972 to present -- Object relations theories -- Melanie Klein (1882-1960), publishing era (1923-1960) -- Donald Winnicott (1896-1971), publishing era (1931-1971) -- Margaret Mahler (1897-1985), publisher era (1938-1980) -- Otto F. Kernberg (1928-), publishing era, 1963 to the present -- Life Cycle Theory -- Erik Erikson (1902-1994), publishing era (1937-1980) -- Interpersonal theory -- Harry Stack Sullivan (1892-1949), publishing era (1925-1947) -- Theories of the self -- Daniel Stern (1934-), publishing era, 1963 to the present -- Heinz Kohut (1913-1981), publishing era (1950-1984) -- Attachment theories -- Traditional attachment theories -- John Bowlby (1907-1990), publishing era (1952-1990) -- Mary Salter Ainsworth (1913-1999), publishing era (1951-1999) -- Neurodevelopmental attachment theories: the return to psychoanalysis -- Allen N. Schore (1943-), publishing era, 1991 to the present -- Peter Fonagy (1952-), publishing era, 1984 to the present.
  • 2010 ScienceDirect
    Matt Carter, Jennifer C. Shieh.
    Whole brain imaging -- Animal behavior -- Stereotaxic surgeries and in vivo techniques -- Electrophysiology -- Microscopy -- Visualizing nervous system structure -- Visualizing nervous system function -- Identifying genes and proteins of interest -- Molecular cloning and recombinant DNA technology -- Gene delivery strategies -- Making and using transgenic organisms -- Manipulating endogenous genes -- Cell culture techniques -- Biochemical assays and intracellular signaling.
    Also available: Print – 2010
  • 2011 WHO
    "... presents the public health significance of ships in terms of disease and highlights the importance of applying appropriate control measures"--Back cover.
    Also available: Print – 2011
  • 2009 Springer
    E. Nigel Wardle.
  • 2014 Springer
    Federico Cappuzzo.
    Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.
  • 2015 Springer
    Federico Cappuzzo.
    Introduction -- Therapy options for advanced NSCLC -- Resistance to EGFR TKIs -- Overcoming EGFR-TKI resistance -- Resistance to crizotinib and therapeutic options -- Resistance to angiogenic drugs and therapeutics options.- Conclusions.
  • ScienceDirect
    edited by William J. Lennarz, Gerald W. Hart.
    Also available: Print – 1994
  • ScienceDirect
    edited by Paul M. Wassarman, Melvin L. DePamphilis.
    Also available: Print – 1993
  • 2010 ScienceDirect
    edited by Paul M. Wassarman and Philippe Soriano.
    Also available: Print – 2010
  • 2010 ScienceDirect
    edited by Paul M. Wassarman and Philippe M. Soriano.
    Also available: Print – 2010
  • 2013 CRCnetBASE
    author, Khaled El Emam.
    "Foreword Personal health information comprises the most sensitive and intimate details of one's life, such as those relating to one's physical or mental health, and the health history of one's family. Intuitively, we understand the importance of protecting health information in order to ensure the confidentiality of such personal data and the privacy of the individual to whom it relates. Personal health information must also be accurate, complete, and accessible to health care practitioners in order to provide individuals with necessary health care. At a broader level, for secondary uses that go beyond the treatment of the individual, health-related data are needed for the benefit of society as a whole. These vitally important secondary uses include activities to improve the quality of care, health research, and the management of publicly funded health care systems. As the information and privacy commissioner of Ontario, Canada, my role includes the oversight of health privacy legislation governing the collection, use, and disclosure of personal health information by organizations and individuals involved in the delivery of health care services. Ontario's Personal Health Information Protection Act (PHIPA) aims to respect an individual's right to privacy in relationship to his or her own personal health information while accommodating the legitimate need to access health information for well-defined purposes. PHIPA does this in part by establishing clear rules for the use and disclosure of personal health information for secondary purposes. The object of these rules is to maximize the benefits of both respecting personal privacy and making health information accessible for purposes that serve society as a whole"--Provided by publisher.
  • 2014 Cambridge
    D.G. Cunningham-Owens, Professor of Clinical Psychiatry, University of Edinburgh, Division of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK.
    1. The origins of psychopharma -- 2. Some preliminaries -- 3. Acute dystonia -- 4. Parkinsonism -- 5. Akathisia -- 6. Tardive dyskinesia -- 7. Tardive and chronic dystonia -- 8. Special populations -- 9. The clinical examination -- 10. An overview of some standardised recording instruments -- 11. Involuntary movements and schizophrenia: a limitation to the concept of tardive dyskinesia? -- 12. And finally ... the salutary tale of 'atypicality' -- References -- Index.
  • 2008 Thieme Book
    [edited by] A. John Popp ; associate editor, Eric M. Deshaies.
  • 2010 ScienceDirect
    volume editors, Jonathan Weissman, Christine Guthrie, Gerald R. Fink.
    Also available: Print – 2010
  • 2016 Springer
    Nils Lindefors, Gerhard Andersson, editors.
    Introduction (including definitions and history) -- Depression -- Panic disorder and agoraphobia -- Social anxiety disorder -- Specific phobia -- Generalised anxiety disorder -- Obsessive-compulsive disorder -- PTSD -- Insomnia -- Health anxiety (Illness anxiety disorder) -- Eating disorders- Substance abuse -- Pathological gambling -- ICBT with children and adolescents -- ICBT with older people -- Future directions and new technologies.
  • v. 1, 2004, 2006.
    Status: Not Checked OutLane Catalog Record
    v. 1. Recommendations -- Addendum to v. 1.
  • 2011 WHO
    1. Introduction -- 2. A conceptual framework for implementing the Guidelines -- 3. Health-based targets -- 4. Water safety plans -- 5. Surveillance -- 6. Application of the Guidelines in specific circumstances -- 7. Microbial aspects -- 8. Chemical aspects -- 9. Radiological aspects -- 10. Acceptability aspects: Taste, odour and appearance -- 11. Microbial fact sheets -- 12. Chemical fact sheets.
    Also available: Print – 2011
  • 2011 Springer
    Giorgio Stanta, editor.
  • 2015- HighWire
  • 2008 Springer
    Vernard Irvine Adams.
    Autopsy protocol -- Opinion reports -- Other reports -- Style -- Death certification -- Record retention.
  • 1976-
    National Institutes of Health.
    Status: Not Checked OutLane Catalog Record
  • v. 1-2, 2003-06.
    Status: Not Checked OutLane Catalog Record
    v. 1. Coastal and fresh waters -- v. 2. Swimming pools and similar environments.
  • 2007 NAEPP
    National Asthma Education and Prevention Program.
  • 2006
    Rich, Michael.
    Status: Not Checked OutLane Catalog Record
  • 2008
    Rich, Michael.
    Status: Not Checked OutLane Catalog Record
  • 2009 WHO
    These guidelines review the use of medicines such as methadone, buprenorphine, naltrexone and clonidine in combination with psychosocial support in the treatment of people dependent on heroin or other opioids. Based on systematic reviews of the literature and using the GRADE approach to determining evidence quality, the guidelines contain specific recommendations on the range of issues faced in organizing treatment systems, managing treatment programs and in treating people dependent on opioids.--back cover
    Also available: Print – 2009
  • 2006
    Status: Not Checked OutLane Catalog Record
  • 2010
    World Health Organization.
    Status: Not Checked OutLane Catalog Record
    Introduction -- Clinical disease and epidemiology -- Objectives of treatment -- Resistance to antimalarial medicines -- Antimalarial treatment policy -- Diagnosis of malaria -- Treatment of uncomplicated P. falciparum malaria -- Treatment of severe falciparum malaria -- Treatment of malaria caused by P. vivax, P. ovale or P. malariae -- Mixed malaria infections -- Complex emergencies and epidemics -- Case management in the context of malaria elimination -- Mass drug administration.
  • 2015 WHO
    World Health Organization.
    Introduction -- Clinical malaria and epidemiology -- Diagnosis of malaria -- Treatment of uncomplicated P. falciparum malaria -- Treatment of uncomplicated P. falciparum malaria in special risk groups -- Treatment of malaria caused by P. vivax, P. ovale, P. malariae or P. knowlesi -- Treatment of severe malaria -- Management of malaria cases in special situations -- Arteminisin-based combination therapies not currently recommended for general use -- Mass drug administration -- Chemoprevention in special risk groups -- Quality of antimalaria medicines -- Monitoring the efficacy and safety of antimalaria drugs and resistance -- National adaptation of the generic framework for malaria diagnosis and treatment, and implementation -- Annex 1-7.
    Also available: Print – 2015
  • 2009
    World Health Organization, International Society of Surgery, International Association for Trauma Surgery and Intensive Care.
    Status: Not Checked OutLane Catalog Record
  • 2007 HighWire
    Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD).
  • 2009
    [edited by] Christopher R. Brigham ; contributing editors, Craig Uejo, Marjorie Eskay-Auerbach.
    Status: Not Checked OutLane Catalog Record
  • 2008
    medical editor, Robert D. Rondinelli ; section editors, Elizabeth Genovese ... [et al.] ; senior contributing editor, Christopher R. Brigham.
    Status: Not Checked OutLane Catalog Record
    "The emphasis of this edition is on expanding the spectrum of diagnoses recognized in impairment rating. It is desigend to encourage attention to and documentation of functional consequences of the impairment as a part of each physician's detailed history"--Provided by publisher.
  • 2006 Karger
    volume editor, Bruce E. Pollock.
    Evidence-based medicine for neurosurgeons: introduction and methodology / M.E. Linskey -- Evaluation of epidemiologic evidence for primary adult brain tumor risk factors using evidence-based medicine / J.L. Fisher ... [et al.] -- Benign adult brain tumors: an evidence-based medicine review / M. Aghi, F.G. Barker, II -- Pediatric neurosurgery / C.O. Maher, A.A. Cohen-Gadol, C. Raffel -- Cerebrovascular-endovascular / K.M. Cockroft, R.H. Rosenwasser -- Evidence-based guidelines in lumbar spine surgery / D.K. Resnick, M.C. Groff -- Spine: minimally invasive techniques / P.C. Gerszten, W.C. Welch -- An evidence-based medicine review of stereotactic radiosurgery / B.E. Pollock -- Evidenced-based guidelines for traumatic brain injuries / D.W. Marion -- Treatment of chronic pain with neurostimulation / J.K. Birknes, A. Sharan, A.R. Rezai.
  • v. 1-4, 2000-2006. NAP
    Carolyn E. Fulco, Catharyn T. Liverman, Harold C. Sox, editors ; Committee on Health Effects Associated with Exposures During the Gulf War, Division of Health Promotion and Disease Prevention, Institute of Medicine.
    v. 1. Depleted uranium, pyridostigmine bromide, sarin, and vaccines -- v. 2. Insecticles and solvents -- v. 3. Fuels, combustion products, and propellants -- v. 4. Health effects of serving in the Gulf War.
  • 2007
    Aina Julianna Gulya.
    Status: Not Checked OutLane Catalog Record
    Serial photographs of sections of the temporal bones -- The pinna and external auditory canal -- The middle ear -- Pneumatization -- The inner ear -- Neuroanatomy -- Vascular anatomy -- Stereoscopic views of the temporal bone -- Phylogeny and embryology.
  • 2006 Springer
    T. Honjo and F. Melchers (eds.).
    Role of innate immune system and host-commensal mutualism / S. Rakoff-Nahoum and R. Medzhitov -- Molecular networks orchestrating GALT development / D. Finke and D. Meier -- Lymphoid tissue inducer cells in intestinal immunity / I.I. Ivanov, G.E. Diehl, and D.R. Littman -- Specificity and plasticity of memory lymphocyte migration / J. Rodrigo Mora and U.H. von Adrian -- IgA adaptation to the presence of commensal bacteria in the intestine / A. J. Macpherson -- Intestinal IgA synthesis : a primitive form of adaptive immunity that regulates microbial communities in the gut / S. Fagarasan -- B cell recruitment and selection in mouse GALT germinal centers / S. Casola and K. Rajewsky -- Structural insights into antibody-mediated mucosal immunity / A.E. Hamburger, P.J. Bjorkman, and A.B. Herr.
    Also available: Print – 2006
  • 2016 ClinicalKey
    John E. Hall.
  • 2011 NIH
    This study (EGF104911) is designed to evaluate the efficacy and safety of lapatinib in patients with advanced or metastatic breast cancer. Eligible subjects must have ErbB2 overexpressing tumors and are refractory to treatment with anthracycline, taxanes and trastuzumab containing regimens. The study data obtained from EGF104911 will be combined with the data from EGF100642 and integrated analysis will be carried out in order to enhance the credibility of the study results.
  • 2011 ClinicalKey
    [edited by] Robert W Shaw, David Luesley, Ash Monga.
    Surgical anatomy -- Hysteroscopy -- Laparoscopy -- Diathermy and lasers -- Imaging techniques in gynaecology -- One-stop gynaecology: the role of ultrasound in the acute gynaecological patient -- Preoperative care -- Principles of surgery and management of intraoperative complications -- Postoperative care -- Hormones: their action and measurement in gynaecological practice -- Biosynthesis of steroid hormones -- Principles and new developments in molecular biology -- Sexual differentiation: normal and abnormal -- Disorders of puberty -- Control of hypothalamic-pituitary-ovarian function -- Amenorrhoea, oligomenorrhoea and hypothalamic-pituitary dysfunction -- Ovulation induction -- Polycystic ovary syndrome -- Fertilization to implantation -- Disorders and investigation of female reproduction -- Disorders of male reproduction -- Assisted reproduction treatments -- Sporadic and recurrent miscarriage -- Tubal disease -- Ectopic pregnancy -- Hirsutism and virilization -- Premenstrual syndrome -- Menopause -- Fertility control -- Psychosexual medicine -- Menstruation and menstrual disorders -- Uterine fibroids -- Endometriosis -- Epidemiology of gynaecological cancer -- The genetics and molecular biology of gynaecological cancer -- Principles of radiotherapy and chemotherapy -- Novel therapies in gynaecological cancer -- Premalignant disease of the genital tract -- Cancer of the uterine cervix -- Benign disease of the vulva and the vagina -- Malignant disease of the vulva and vagina -- Malignant disease of the uterus -- Gestational trophoblastic tumours -- Benign tumours of the ovary -- Carcinoma of the ovary and fallopian tube -- Benign disease of the breast -- Malignant disease of the breast -- Supportive care for gynaecological cancer patients: Psychological and emotional aspects -- Classification of urogynaecological disorders -- The mechanism of continence -- Urodynamic investigations -- Urethral sphincter incompetence: stress incontinence -- The overactive bladder syndrome -- Voiding difficulty -- Pelvic organ prolapse -- Frequency, urgency and the painful bladder -- Fistulae -- Urinary tract infection -- Lower intestinal tract disease -- Sexual dysfunction in urogynaecology -- Chronic pelvic pain -- Pelvic inflammatory disease -- Non-HIV sexually transmitted infections -- Human immunodeficiency syndrome -- Forensic gynaecology -- Violence against women -- Lesbian and bisexual women's health issues -- Evidence-based care in gynaecology.
  • 2016 ClinicalKey
    Christopher P. Crum, Anna R. Laury, Michelle S. Hirsch, Charles Matthew Quick, and William A. Peters.
    Part of the growing High-Yield Pathology Series, Gynecologic and Obstetric Pathology is designed to help you review the key features of ob/gyn specimens, recognize the classic look of each disease, and quickly confirm your diagnosis. Authors Christopher Crum, MD, Michelle S. Hirsch, MD, PhD, and William Peters III, MD, incorporate a logical format, excellent color photographs, concise bulleted text, and authoritative content to help you accurately identify hundreds of discrete disease entities affecting the female reproductive tract.
  • 2006 Springer
    Patricia J. Eifel ... [et al.], editors ; foreword by Maurie Markman.
    Multidisciplinary care of patients with gynecologic cancers / David M. Gershenson ... [et al.] -- Prevention and early detection of endometrial and ovarian cancers / Karen H. Lu -- Preinvasive disease of the lower genital tract / Andrea Milbourne -- Selected topics in gynecologic pathology / Anais Malpica, Michael T. Deavers, and Elvio G. Silva -- Imaging of gynecologic malignancies / Revathy Iyer -- Contemporary treatment of vaginal and vulvar cancers / Patricia J. Eifel and Thomas W. Burke -- Treatment of early cervical cancer / Charles F. Levenback -- Treatment of locally advanced cervical cancer / Anuja Jhingran, Patricia J. Eifel, and Pedro T. Ramirez -- Uterine sarcomas / Lois M. Ramondetta ... [et al.] -- Treatment of endometrial cancer / Lois M. Ramondetta ... [et al.] -- Surgery for ovarian cancer / Judith K. Wolf and J. Taylor Wharton -- Chemotherapy for epithelial ovarian cancer / Michele L. Donato ... [et al.] -- Treatment of rare ovarian malignancies / Jubilee Brown and David M. Gershenson -- Gestational trophoblastic disease / Hui T. See ... [et al.] -- Fertility-sparing options for treatment of women with gynecologic cancers / Pedro T. Ramirez -- Quality of life and sexual functioning / Diane C. Bodurka and Charlotte C. Sun -- Palliative care for gynecologic malignancies / Florian Strasser, Michael W. Bevers, and Eduardo Bruera.
  • 2011 ClinicalKey
    [edited by] Julia R. Fielding, Douglas L. Brown, Amy S. Thurmond.
    Section 1. Imaging techniques, pitfalls, and normal anatomy -- section 2. Pelvic pain -- section 3. Abnormal bleeding -- section 4. Infertility -- section 5. First-trimester pregnancy complications -- section 6. Postpartum complications -- section 7. Characterization of the adnexal mass -- section 8. Gynecologic cancer -- section 9. Pediatric imaging -- section 10. Interventional radiology in gynecology.
  • 2015 Springer
    Ramez N. Eskander, Robert E. Bristow, editors.
    During this age of advanced technology, there is an incredible amount of dynamic literature surrounding the diagnosis and treatment of gynecologic cancers. Despite this information surplus, house officers and junior faculty studying gynecologic oncology indicate a need for a reliable, easily accessible, streamlined resource for everyday use. Gynecologic Oncology: A Pocketbook is a collaborative effort that combines the perspectives of expert faculty and fellows in training in the field of gynecologic oncology. Not only is it incredibly portable, but the format in which the information is presented (bullet point, outline, tables and diagrams) allows for rapid access to valuable information and is unique amongst existing texts. This distinct pocketbook will provide the information needed to care for patients with gynecologic malignancies appropriately and will promote critical thinking throughout treatment.
  • 2009 ClinicalKey
    edited by Marisa R. Nucci, Esther Oliva.
    This new title in the Foundations in Diagnostic Pathology series offers today's most essential gynecologic pathology know-how in a compact, high-yield format! For each pathologic entity examined, you'll find discussions of clinical features, pathologic features (gross and microscopic), as well as ancillary studies, differential diagnosis, and prognostic and therapeutic considerations. The text's pragmatic, well-organized approach, complemented by abundant full-color, high-quality illustrations and at-a-glance tables, makes it easy for you to access the information you need to quickly and accurately identify pathology specimens. The result is a practical, affordable resource for study and review as well as for everyday clinical reference. Covers both neoplastic and non-neoplastic conditions of the female reproductive tract to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features ; pathologic features (gross and microscopic) ; ancillary studies ; differential diagnoses ; and prognostic and therapeutic considerations, making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout, enhancing the presentation and accessibility of the material. Offers hundreds of full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens.
  • 2011 Springer
    Akila N. Viswanathan ... [et al.], editors.
    Imaging of gynecologic malignancies -- The use of sectional imaging with CT and MRI for image-guided therapy -- The physics of CT and MR imaging -- The use of positron emission tomographic imaging for image-guided therapy -- Image-guidance in external beam planning for locally advanced cervical cancer -- Physics perspectives on the role of 3D imaging -- Image-guided treatment planning and therapy in postoperative gynecologic malignancies -- The integrating of 3D imaging with conformal radiotherapy for vulvar and vaginal cancer -- Adaptive contouring of the target volume and organs at risk -- Clinical aspects of treatment planning -- Radiobiological aspects of brachytherapy in the era of 3D imaging -- Physics for image-guided brachytherapy -- Australia: Peter Maccullum Cancer Center, Melbourne -- Austria: Medical University of Vienna, Vienna -- Belgium: University Hospital, Leuven -- Denmark: Aarhus University Hospital, Aarhus -- France: Institut Gustave-Roussy, Paris -- Great Britain: Mount Vernon Cancer Center, Middlesex -- India: Tata Memorial Hospital, Mumbai -- The Netherlands: University Medical Center, Utrecht -- USA: Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston -- USA: Medical College of Wisconsin, Milwaukee -- Postoperative vaginal cylinder brachytherapy in an era of 3D imaging -- Image-based approaches to interstitial brachytherapy -- Outcomes related to the disease and the use of 3D-based external beam radiation and image-guided brachytherapy -- Morbidity related to the use of 3D-based external beam radiation and image-guided brachytherapy.
  • 2014 ClinicalKey
    Beryl R. Benacerraf, Steven R. Goldstein, Yvette S. Groszmann.
    For pelvic symptoms, ultrasound is the initial imaging modality of choice in today's cost-conscious climate. Employing a practical, problem-based approach Gynecologic Ultrasound is the only medical reference that provides a stepwise method in the diagnosis of gynecological abnormalities. Abundantly illustrated and easily accessible, it is an ideal resource for a clinical setting. Expedite and confirm diagnosis of gynecological abnormalities. An easily accessible format-organized by both entity and differential diagnosis-facilitates searches and zeroing in on the one correct entity. Master the nuances of using ultrasound through the visual instruction of more than 600 clear images including 3D and Doppler - important and necessary tools for pelvic ultrasound. Glean all essential, up-to-date, need-to-know information about Mullerian Duct Abnormality, Endometriosis, Ovarian cancer, and Uterine Sarcoma as well as normal pelvic ultrasound and common normal variants. Consult this reference where and when you need it at Expert Consult.
  • 2013 Springer
    Walid E. Khalbuss, Marilee Means, editors.
    Gynecological and Breast Cytopathology Board Review and Self-Assessment is a comprehensive systems-based review of gynecological and breast cytology in