Bookedited by Arun K. Shukla.
Contents:
Intro
GPCR Signaling in Cancer
Copyright
Contents
Contributors
Chapter One: Atypical chemokine receptors in tumor cell growth and metastasis
1. Introduction
2. Specific ACKRs
2.1. ACKR1/DARC
2.2. ACKR2/D6
2.3. ACKR3/RDC1/CXCR7
2.3.1. Normal tissue distribution of ACKR3
2.3.2. ACKR3 expression in tumor tissues and cells
2.3.3. Structure and function of ACKR3
2.3.4. ACKR3 and mitogenic signaling
2.3.5. ACKR3 as a regulator of tumor cell migration
2.3.6. ACKR3 as a biomarker for tumor progression
2.3.7. Inhibitors of ACKR3 activities 2.4. ACKR4/CCRL1
2.5. ACKR5/CCRL2
2.6. ACKR6/PITPNM3/Nir1
Acknowledgment
References
Chapter Two: The G protein coupled receptor CCR5 in cancer
1. Genetics of cysteine-cysteine chemokine receptor type (CCR5)
2. CCR5 and biochemical signaling
3. CCR5 antagonists retasked in cancer (Jiao et al., 2018)
4. CCR5 induces the hallmarks of cancer
4.1. Activating invasion and metastasis (Jiao et al., 2018
Velasco-Velazquez et al., 2012)
4.2. Avoiding immune destruction-the anti-tumor immune response (Blattner et al., 2018
Hawila et al., 2017) 4.3. Induction of proliferative signaling, angiogenesis (Ben-Baruch, 2012
Soria Ben-Baruch, 2008) and resistance to cell ...
4.4. Deregulated cellular energetics and cancer stem cells
5. Preclinical analysis of CCR5 inhibition in metastatic cancer
6. Clinical studies
Acknowledgments
Conflict of interest
References
Chapter Three: Targeting G protein-coupled receptors in cancer therapy
1. Introduction
2. Domain-specific GPCR-targeted therapeutics
3. GPCR extracellular domain-specific targeted therapy
3.1. Chemokine receptors
3.2. Protease-activated receptors 3.3. Lysophosphatidic acid receptors
3.4. Sphingosine-1-phosphate receptors
4. The intracellular domain as an attractive therapeutic target
5. Targeting the GPCR ICD and its signaling proteins
6. Targeting GPCR-specific signal transduction intermediates
7. GPCR-derived Hippo-YAP-TAZ signaling as a therapeutic target
8. GPCR-derived Wnt signaling as a therapeutic target
9. Future perspectives
Funding
Conflicts of interest
References
Chapter Four: The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical ... 1. Introduction
2. Molecular cell biology and physiological roles of ACKRs
2.1. ACKR1
2.2. ACKR2
2.3. ACKR3
2.4. ACKR4
3. The roles of ACKRs in animal tumor models
3.1. ACKRs in primary tumor growth and metastasis
3.2. ACKRs in angiogenesis
3.3. ACKRs in inflammation and tumor immunity
3.4. Dual, tumor context-specific effects of ACKRs
4. ACKR expression in patient samples and correlation with clinical outcome
4.1. ACKR1 and ACKR2
4.2. ACKR3
4.3. ACKR4
4.4. Co-expression of ACKR1, ACKR2 and ACKR4
4.5. ACKRs predicting therapy response