BookCheorl-Ho Kim.
Summary: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
Contents:
Intro
Contents
Chapter 1: History of Sialic Acids, Gangliosides, and GM3
References
Chapter 2: Synthesis of GM3
Chapter 3: Molecular Localization of GM3 in Cells
References
Chapter 4: Basic Function of GM3 as an Interacting Molecule
References
Chapter 5: GD3 Mimetics with a Neurite Forming Capacity
5.1 GD3 Mimetic of Deuterostome Echinoderms
5.2 GM4-Type and Hematoside-Type Ganglioside Show Immune-Modulating Capacities
References
Chapter 6: GM3 as a Pathogenic Infection Receptor
References Chapter 18: GM3, Caveolin-1 and Insulin Receptor in Insulin Resistance
References
Chapter 19: GM3 Suppresses Arthritis
References
Chapter 20: GM3 Protects Cochlear Hair Cells and Hearing from Corti Degeneration
References
Chapter 21: GM3 Increases Osteoclast Differentiation Via Direct Cooperation with RANKL and IGF-1
References
Chapter 22: GM3 Induces Terminal Differentiation of Leukemic Cells
22.1 GM3 Differentiation Role in Human Leukemic Monocyte Model: THP-1 Cell
22.2 GM3 Roles in Both Monocytoid and Granulocytoid Differentiation of HL-60 Cells Chapter 7: GM3 and Related Gangliosides Prevent Inflammation and Atherosclerosis
References
Chapter 8: GM3 Has an Anti-tumor Capacity
References
Chapter 9: GM3 Suppresses Tumor Angiogenesis
References
Chapter 10: Interaction Between EGFR and GM3
References
Chapter 11: Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling
References
Chapter 12: Regulation of GM3-Mediated EGFR Signaling by NEU3 Sialidase
References
Chapter 13: VEGFR-GM3 Interaction in Angiogenesis
13.1 Soluble sFLT1 Directly Recognize GM3 Embedded in the Lipid Rafts