Bookedited by Jolanta Barańska.
Summary: Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
Contents:
Introduction to purinergic signaling in the brain
Adenosine signaling in glioma cells
Cross-talk in nucleotide signaling in glioma c6 cells
Calcium signaling in glioma cells
the role of nucleotide receptors
Purinergic signaling in glioma progression
Cytoskeleton and nucleotide signaling in glioma c6 cells
Signaling determinants of glioma cell invasion
Receptor tyrosine kinases: principles and functions in glioma invasion
Recent advances in understanding mechanisms of tgf beta signaling and its role in glioma pathogenesis
Stat signaling in glioma cells
Cannabinoid signaling in glioma cells
Effects of arginine and its deprivation on human glioblastoma physiology and signaling
Histone modifying enzymes and chromatin modifiers in glioma pathobiology and therapy responses
Role of infiltrating microglia/macrophages in glioma. .