Bookedited by Geoffrey S. Ginsburg, Huntington F. Willard.
Summary: "Genomic and Precision Medicine: Translation and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care"--Publisher's description.
Contents:
Application of human genome information to clinical practice
Genome sequencing: new technologies, approaches, applications
Clinical applications of whole-genome chromosomal microarray analysis
Transcriptomics in the age of ultra high-throughput sequencing
Quantitative proteomics in genomic medicine
Translating genome information into clinical practice and human health
Big data and translational bioinformatics genomic and personalized medicine
Biospecimen banking linked to phenotype data
Electronic health records
Data sharing and privacy
Designing genome-based clinical studies
Developing the evidence to support clinical use genomic biomarkers as diagnostics
Strategies in the adoption of genome-based diagnostics
Companion diagnostics
Health risk assessment and family history
Clinical decision support
Implementation science and integration into healthcare systems
Pharmacogenetics and pharmacogenomics
Drug repurposing and repositioning
Point of care devices
Overview of policy, ethical and social considerations
Educational issues and strategies for genomic medicine:
For professionals
For the public
Regulation of genomic technologies
Economic value of genomic medicine
Reimbursement
Impact of patents on genomic medicine.