Books

Contents:
Overview of genetic analysis of human opioid receptors / Santi M. Spampinato
Computational structural biology of opioid receptors / Davide Provasi
Analysis of epigenetic mechanisms regulating opioid receptor gene transcription / Cheol Kyu Hwang [and three others]
Renilla luciferase reporter assay to study 3'UTR-Driven posttranscriptional regulations of OPRM1 / Gabriele Vincelli and Andrea Bedini
High-throughput gene expression profiling of opioid-induced alterations in discrete brain areas / Michal Korostynski [and three others]
Real-time imaging of mu opioid receptors by total internal reflection fluorescence microscopy / Cristina Roman-Vendrell and Guillermo Ariel Yudowski
In vivo techniques to investigate the internalization profile of opioid receptors / Amynah A. Pradhan [and three others]
Monitoring opioid receptor dimerization in living cells by bioluminescence resonance energy transfer (BRET) / Monica Baiula
Analysis of potassium and calcium imaging to assay the function of opioid receptors / Viola Spahn, Dinah Nockemann, and Halina Machelska
Electrophysiological patch clamp assay to monitor the action of opioid receptors / Viola Spahn, Dinah Nockemann, and Halina Machelska
Skin-nerve preparation to assay the function of opioid receptors in peripheral endings of sensory neurons / Rabih Moshourab, Yvonne Schmidt, and Halina Machelska
Mechanical nociception measurement in mice and rats with automated Von Frey equipment / Gabriele Campana and Roberto Rimondini
Detecting zinc release induced by mu-opioid receptor agonists in brain slices / María Rodríguez-Muñoz [and three others]
Opioid receptors : methods for detection and their modes of actions in the eye / Shahid Husain
Evaluation of murine macrophage cytokine production after in vivo morphine treatment / Silvia Franchi [and four others]
Measurement of macrophage toll-like receptor 4 expression after morphine treatment / Mara Castelli [and three others]
The role of opioid receptors in migration and wound recovery in vitro in cultured human keratinocytes and fibroblasts / Mei Bigliardi-Qi and Paul L. Bigliardi
Role of opioid receptors in the reinstatement of opioid- seeking behavior : an overview / Liana Fattore [and three others]
Analysis of opioid-seeking reinstatement in the rat / Liana Fattore [and three others]
Induction of a high alcohol consumption in rats and mice : role of opioid receptors / Roberto Rimondini and Gabriele Campana
Evaluation of social and nonsocial behaviors mediated by opioids in mouse pups / Francesca R. D'Amato.

Summary: "The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the brain's cognitive system, the brain's motivational system, antidepressant prescription patterns, antidepressant-like effects of opioid receptor modulators, the behavioral effects of antidepressant and anxiolytic drugs, and more"--Publisher's description.

Contents:
Brain's cognitive system
Brain's motivational system
Antidepressant prescription patterns
Antidepressant-like effects of opioid receptor modulators
Behavioral effects of antidepressant and anxiolytic drugs
Opioid system in regulating of neuroinflammation and immune function.

Contents:
Intro
Preface
Contents
Contributors
Part I: An Opioid Crisis with Pediatric Implications
Chapter 1: Epidemiology and Public Health Implications of the Opioid Crisis
Addiction and the Rise of the Opioid Epidemic
The Origins of the Contemporary Opioid Crisis
Health and Public Health Implications of the Opioid Epidemic
History of Addiction Treatment
Current Approach to Addiction Treatment
Medication for Opioid Use Disorder
Behavioral Health Treatment for Opioid Use Disorder
Special Populations
Pregnancy, Neonatal Abstinence Syndrome, and Breastfeeding Adolescents
Overdose Prevention and Harm Reduction
References
Chapter 2: The Impact of the Opioid Crisis on Neonates, Children, and Adolescents
Introduction
Neonatal Abstinence Syndrome
Epidemiology
Clinical Implications
Challenges of Caring for NAS Infants
Long-Term Outcomes
Opioid-Related Morbidity and Mortality in Children and Adolescents
Epidemiology of Hospitalizations for Pediatric Opioid Poisonings
Epidemiology of Fatal Pediatric Opioid Poisonings
Circumstances Surrounding Fatal Pediatric Opioid Poisonings
Pediatric and Adult Mortality Trends Implications of Adult and Teen Opioid Misuse on Young Children
Need for Pediatric-Specific Interventions and Further Research
Conclusions
References
Chapter 3: Legal Issues in Pediatric Opioid Therapy
How Can State and Federal Government Help with Opioid Misuse in the Pediatric Population?
Government Hierarchy
Food and Drug Administration
Current Initiatives
Drug Enforcement Agency
Centers for Disease Control
Prescription Drug Monitoring Programs
Prescribing Opioids, Informed Consent, and Minors
Consent for Opioid Prescribing Adolescents and Medication-Assisted Therapy (MAT)
Impact of Current Laws and Guidelines
Proposed Action Plan for Clinicians
References
Chapter 4: The Impetus for Recognizing, Preventing, and Treating Pain in the Pediatric Population
Introduction
Acute Pain
Pain in Neonates
Procedural Pain
Chronic Pain
Conclusions
References
Chapter 5: Evidence-Based Guidelines for Opioid Therapy in Pediatrics
Introduction
Patterns of Opioid Prescribing in Children and Adolescents in the United States Problematic Opioid Use Behaviors Following a Legitimate Opioid Prescription
Guidelines on Opioid Prescribing
Implications of Opioid Guidelines for Pediatric Pain Management
Efforts in State of Washington
References
Part II: Considerations for Safe Opioid Prescribing in Pediatrics
Chapter 6: Neonatal and Pediatric Pharmacology
Introduction
Potential Opioid-Drug Interactions
Polymorphism Impact on Opioid Analgesia and Adverse Effects
Obesity and Opioid Dosing
Opioid Clearance
Safety of Opioid Prescription
Morphine
Hydromorphone
Codeine
Hydrocodone

Summary: "Gain vital guidance and support when treating the high-risk, high-reward population of women confronting (or battling) opioid-use disorders during pregnancy. Large numbers of pregnant women are dependent on opioids and require comprehensive non-judgemental care to replace traditional approaches of incarceration and child welfare involvement that worsen outcomes for both mother and infant. Invaluable and comprehensive, this toolkit provides the key to non-judgemental care for both mother and baby, throughout labor, delivery management and postpartum care. Bridge the important treatment gap through this evidence-based, caring approach; standardizing exceptional care, for obstetricians, pediatricians, addictionists, and anyone caring for pregnant women with opioid-use disorders. Edited by a Board-certified expert in Obstetrics, Gynecology and Addiction Medicine, and a team of internationally-acclaimed leaders in Women's Health, this guide provides high-quality advice, guidelines and vital skills to tackle a currently expanding, opioid epidemic"-- Provided by publisher.

Contents:
The opioid epidemic and pregnant women ; Screening brief intervention and referral to treatment for opioid use disorders in pregnancy / Tricia E. Wright
Substance use assessment during pregnancy / Jacquelyn Starer and Carl Christensen
Co-occurring mental health conditions in pregnant women with opioid use disorders / Alexis S. Hammond and Margaret S. Chisolm
Trauma and posttraumatic stress disorder in women with opioid-use disorder in pregnancy / Soraya Asadi
Intimate partner violence, pregnancy and substance use disorder / Richard G. Soper and Hendrée E. Jones
Medical comorbidities in women with opioid use disorders in pregnancy / Kaylin A. Klie
Harm reduction principles in women with opioid use disorder in pregnancy / Lauren Owens and Mishka Terplan
Prenatal care in substance-using pregnant women / Charles S. Schauberger
Treatment approaches in women with substance use disorders who become pregnant / Hendrée E. Jones
Medication assisted treatment for opioid use disorder during pregnancy / Lawrence Leeman and Jacquelyn Starer
Labor and delivery management in women with substance use disorder / Marjorie Meyer and Tricia E. Wright
Postpartum care for women with substance use disorders / Elizabeth E. Krans, Sebastian T. Tong and Mishka Terplan
Neonatal abstinence syndrome / Karol Kaltenbach and Loretta Finnegan
Breastfeeding and the substance-exposed dyad / Lauren M. Jansson and Stephen W. Patrick.

Summary: This book provides a concise yet comprehensive overview on the use of opioids in the ICU, offering practical, real-world recommendations on opioid utilization and alternative therapies. The text explains the physiology and assessment of pain and the need for analgesia in the ICU, details the pharmacology of opioids and their use in providing analgesia, sedation, and comfort for patients during critical illness, and summarizes advanced pharmaceutical and surgical approaches to pain management and procedural applications that can supplement, minimize, or replace opioids for the ICU patient. The book also includes algorithms and step-by-step approaches on navigating the delicate balance between the relief of suffering and the adverse effects of opioids, as well as a dedicated section on the management of critically ill patients with preexisting opioid tolerance. Written by experts in the field, Opioid Use in Critical Care: A Practical Guide is a valuable resource for ICU providers who treat and manage critically ill patients with opioids.

Contents:
Epidemiology of Opioid Use
Assessment of Pain in the ICU
Pharmacology and Pharmacokinetics of Opioids in the ICU
Opioid Analgesics Interactions with other Drugs
Side Effects of Opioid Analgesic Therapy
Rational Selection and Utilization of Opioid Analgesics in Critical/Acute Care
Monitoring of Opioid Analgesic Use and its Effects in Acute Care
Opioid Tolerance and Hyperalgesia in the ICU
Strategies to Prevent and Treat Opioid Tolerance and Hyperalgesia in the ICU, I
Strategies to Prevent and Treat Opioid Tolerance and Hyperalgesia in the ICU, II
Interaction of Opioids with Sedative Practices in the ICU
Acute Pain Management in Patients with Opioid Dependence
Management of Opioid Overdose
Use of Opioid Analgesics in Post-Surgical and Trauma Patients
Post intensive Care Syndrome and the Potential Long-Term Effects of Pain and Opioid Therapy in the ICU
Special ICU Populations: Opioids in Neurocritical Care
Special ICU Populations: Opioids in Geriatrics
Special ICU Populations: Opioids in Obstetrics, Labor & Delivery.

Summary: This book brings together information on all aspects of ossification of the posterior longitudinal ligament (OPLL), a hyperostotic condition of the spine that can cause severe neurological deficits. Since the second edition of this book was published in 2006, there have been tremendous advances in the field, and this third edition provides updated information on the disease's epidemiology, diagnosis and treatment, while also addressing ossification of the ligamentum flavum (OLF) and diffuse idiopathic spinal hyperostosis. As such, it offers a valuable resource for all those who want to gain a deeper understanding of OPLL/OLF and those involved in making decisions about its treatment.

Contents:
Part 1 Introduction
1 History of research
Part 2 Epidemiology
2 An Overview of Epidemiology and Genetics
3 OPLL: Disease entity, prevalence, literature research, and growth
4 Natural History of Ossification of the Posterior Longitudinal Ligament (OPLL)
Part 3 Pathology & Pathogenesis
5 Overview of Recent Basic Researches on OPLL and OLF
6 Histopathological Features of Ossification of the Posterior Longitudinal Ligament
7 Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities
8 A Short History of Genetic Study of OPLL
9 Overview of possible roles of OPLL-associated genes in OPLL development
10 Application of iPS cell technology for OPLL
11 Mechanisms underlying OPLL development in Tiptoe Walking (ttw) Mice
12 In vivo tracing of neural tracts in tip-toe walking Yoshimura mice by diffusion tensor tractography
13 Metabolomics analysis in OPLL patients
Part 4 Diagnosis
14 Diagnosis of OPLL and OLF: overview
15 Clinical manifestation of cervical OPLL
16 Three-dimensional imaging of cervical ossification of the posterior longitudinal ligament
17 Clinical manifestations of thoracic ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligament flavum (OLF)
18 Evaluation of distribution patterns of spinal ligament ossification using whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament
19 Diagnostic imaging of thoracic OPLL and OLF
20 Biomechanics of the spinal cord compression due to cervical ossification of the posterior longitudinal ligament
Part 5 Treatment
21 Surgical Indications and Choice of Surgical Procedure for Cervical Ossification of the Longitudinal Ligament
22 Overview of Laminoplasty
23 Open-door Laminoplasty for Cervical OPLL: Technique, Long-term Results, and Complications
24 Double-door Laminoplasty for Cervical OPLL : Technique, Complications and Long-term Results
25 Posterior Decompression and Fusion for Cervical OPLL: Indication and Technique
26 Anterior Cervical Decompression for Cervical OPLL: Technique, Complications and Long-term Results
27 Surgical Indications and Choice of Surgical Procedure for Thoracic OPLL
28 Posterior decompression and fusion for thoracic OPLL: surgical techniques, outcomes, timing and complications
29 Anterior Decompression and Fusion for Thoracic OPLL: Transthoracic and Transsternal Approaches
30 Circumferential Decompression Through Posterior Approach for Thoracic OPLL: Technique and Complications
31 Surgery for ossification of the ligamentum flavum: posterior decompression with or without fusion
32 Computer-Aided Surgery for Ossification of the Spinal Ligaments
33 Surgical Treatment of Thoracic Ossification of the Posterior Longitudinal Ligament: Intraoperative Spinal Cord Monitoring
34 Intraoperative ultrasonography for patients with ossification of the posterior longitudinal ligament.

Contents:
Behaviours and disorders
Developmental perspectives
Basic issues on aetiology
Individual characteristics
Environmental characteristics
Clinical assessment
Intervention and intervention development
Behavioural parent training
Cognitive behavioral therapy
Pharmacotherapy
Multicomponent intervention
Factors which influence intervention delivery and outcomes.

Summary: "Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating light's temporal and spatial profile enabled precise control of membrane potentials. This feature has inspired non-opsinbased optogenetics, which inherits the precise spatiotemporal resolution but expands the targets into a diverse pool of biomolecules such as membrane receptors, ion channels,kinases, GTPases, and transcription factors. This book is unique because it emphasizes the design and applications of opsin-free optogenetic tools."-- Provided by publisher.

Contents:
Optogenetic dissection of a two-component calcium influx pathway / Xiaoxuan Liu, Yingshan Wang, Yubin Zhou, and Guolin Ma
High-throughput engineering of a light-activatable Ca2 channel / Lian He, Liuqing Wang, and Youjun Wang
Optogenetic activation of TrkB signaling / Peiyuan Huang, Zhihao Zhao, Lei Lei, and Liting Duan
Spatiotemporal modulation of neural repair / Huaxun Fan, Qin Wang, Kai Zhang, and Yuanquan Song
Optogenetic control of neural stem cell differentiation / Yixun Su, Taida Huang, Kai Zhang, and Chenju Yi
An optogenetic toolbox for remote control of programmed cell death / Ningxia Zhang and Ji Jing
Control of protein levels in Saccharomyces cerevisiae by optogenetic modules that act on protein synthesis and stability / Sophia Hasenjäger, Jonathan Trauth, and Christof Taxis
Optogenetics as a tool to study neurodegeneration and signal transduction / Prabhat Tiwari and Nicholas S. Tolwinski
Opsin-free optogenetics : brain and beyond / Jongryul Hong, Yeonji Jeong, and Won Do Heo
Constructing a far-red light-induced split-Cre recombinase system for controllable genome
Engineering / Meiyan Wang, Jiali Wu, and Haifeng Ye
Tools and Technologies for Wireless and Non-invasive Optogenetics / Guangfu Wu, Vagif Abdulla, Yiyuan Yang, Michael Schneider, and Yi Zhang.

Summary: This book discusses more than one hundred patients in which visual pathway is involved, and focuses on the role of visual field examination in the diagnosis of these diseases. It also highlights the application of concepts from the new interdiscipline, integration medicine as well as molecular biology and genetics in the analysis of the diseases. In this book, the commonly (typically) noticed changes in the visual field of patients with visual pathway disorders are mainly described in the chapter one titled as “Visual Field-related Anatomy of Visual Pathway” and chapter two titled as “Interpretation of Visual Field Test”, while the majority of the cases presented with "atypical" changes in visual field. At this point, the changes in the visual field could function as either a key to understand the disease, or a question mark which confuses the diagnosis. However, the process of pushing aside a fog around the diagnosis step by step helps the readers to gradually disclose the essence of the disease.

Contents:
Optic disc size
Optic disc shape
Optic cup shape and depth
Optic cup size in relation to the optic disc size
Neuroretinal rim size, shape and perfusion
Central retinal vessel trunk location
Optic disc hemorrhages
Parapapillary chorioretinal atrophy
Retinal arteriole diameter
Retinal nerve fiber layer defects.

Summary: The book provides a detailed description in color format of the optic nerve head changes that occur in glaucoma. It explains the normal and variant anatomy of an optic nerve head and why certain discs are more or less likely to develop glaucomatous changes. This book attempts to explain the anatomical basis of common and not so common signs seen in optic nerve head and retinal nerve fibre layer as captured by a digital fundus imaging system and optical coherence tomography. It also includes optic nerve head conditions mimicking glaucoma. The book is relevant for practicing ophthalmologists, vision science researchers, clinical optometrists, postgraduate residents in ophthalmology, sub-specialty fellows as well as general ophthalmologists, neurologists and neurosurgeons.

Contents:
What is the range of normal variations in the optic nerve head appearance?
What are the characteristic changes to the optic nerve head in glaucoma and how do they evolve over time?
How to interpret optic disc in myopes?
What are the key clinical skills and investigative techniques for disc evaluation?
How to reduce error in optic nerve head examination?
What imaging errors occur when evaluating the optic nerve head?
How to interpret difficult optic discs?
How to accurately assess the severity in people with glaucoma or at risk for developing glaucoma
What optic nerve head conditions mimic glaucoma?
Getting better - Learning, new tools and risk management.

Contents:
Basics and guide to image interpretation with normal and anatomic variants
Genetic abnormalities
Macular degeneration
Diabetic Retinopathy
Retinal Vascular Disease
Vitreo-macular adhesion/traction syndromes and the effects of vitrectomy surgery
Toxic and Nutritional Conditions
Uveitis
Glaucoma and other optic neuropathies.

Summary: This book focuses on the practical aspects of Optical Coherence Tomography (OCT) in glaucoma diagnostics offering important theoretical information along with many original cases. OCT is a non-invasive imaging technique that acquires high-resolution images of the ocular structures. It enables clinicians to detect glaucoma in the early stages and efficiently monitor the disease. Optical Coherence Tomography in Glaucoma features updated information on technical applications of OCT in glaucoma, reviews recently published literature and provides clinical cases based on Cirrus and Spectralis OCT platforms. In addition, newer techniques like event and trend analyses for progression, macular ganglion cell analysis, and OCT angiography are discussed. This book will serve as a reference for ophthalmologists and optometrists worldwide with a special interest in OCT imaging providing essential guidance on the application of OCT in glaucoma.

Contents:
Part I: Optical Coherence Tomography in Glaucoma, Basics
Chapter 1:Optical Coherence Tomography: Introduction, History and Current Status
Chapter 2:Optical Coherence Tomography: Basics and Technical Aspects
Chapter 3:Role of Optical Coherence Tomography in Glaucoma
Chapter 4:Optical Coherence Tomography: Manufacturers and Current Systems
Part II:How to Interpret the Optical Coherence Tomography Results
Chapter 5:Interpretation of Imaging Data From Cirrus HD-OCT
Chapter 6:Interpretation of Imaging Data From Spectralis OCT
Chapter 7:Examples of Optical Coherence Tomography Findings in Glaucoma Eyes with Varying Stages of Severity
Chapter 8:Artifacts and Anatomical Variations in Optical Coherence Tomography
Chapter 9:Optical Coherence Tomography in Non-Glaucomatous Optic Neuropathies
Chapter 10:Utility of Optical Coherence Tomography for Detection or Monitoring of Glaucoma in Myopic Eyes
Chapter 11:Anterior Segment Optical Coherence Tomography in Glaucoma
Part III:Optical Coherence Tomography and Progression
Chapter 12:Optical Coherence Tomography and Progression
Chapter 13:Cirrus HD-OCT's Guided Progression Analysis
Chapter 14:Spectralis OCT's Progression Analysis
Chapter 15:Optical Coherence Tomography Progression Analysis: Sample Cases
Part IV:Structure and Function
Chapter 16:Combining Structure and Function in Glaucoma
Part V:Optical Coherence Tomography Angiography in Glaucoma
Chapter 17:Optical Coherence Tomography Angiography (OCTA).

Summary: This book is a highly illustrated, practical guide to anterior segment optical coherence tomography (OCT) with numerous photographs and didactic information throughout. Clear and concise chapters outline the diagnostics of the anterior segment of the eye with clinical advice given to support ophthalmic surgeons with pre and intraoperative surgery planning as well as postoperative follow-up care. Optical Coherence Tomography of the Anterior Segment will be a useful resource for everyday practice to allow clinicians to grow their expertise in this patient-friendly and common diagnostic procedure. As the procedure continues to gain popularity, this book will be an indispensable resource for all levels of ophthalmologist who wish to improve their knowledge and techniques of anterior segment OCT. .

Contents:
History and future of anterior segment OCT
Physical principles of anterior segment OCT
Anatomy and traumatology of the anterior segment of the eye
Conjunctiva and eyelids
Degenerative diseases and deposits of the cornea
Inflammatory corneal diseases
Corneal Dystrophies
Refractive and therapeutic corneal surgery
Corneal Transplantations
Anterior eye camber and chamber angle
Iris
Refractive lens surgery.

Summary: The book introduces readers to the basic principle of optical imaging technologies. Focusing on human disease diagnostics using optical imaging methods, it provides essential information for researchers in various fields and discusses the latest trends in optical imaging. In recent decades, there has been a huge increase in imaging technologies and their applications in human diseases diagnostics, including magnetic resonance imaging, x-ray computed tomography, and nuclear tomographic imaging. This book promotes further developments to extend optical imaging to a wider range of disease diagnostics. It is a valuable resource for researchers and students in the field of biomedical optics, as well as for clinicians.

Contents:
Chapter 1. Introduction
Chapter 2. Fundamentals of optical imaging
Chapter 3. Super-resolution imaging
Chapter 4. Two-photon fluorescence imaging
Chapter 5. Two-photon phosphorescence lifetime microscopy
Chapter 6. Whole body fluorescence imaging
Chapter 7. Scattering-based whole brain imaging
Chapter 8. Long-term time-lapse multimodal intravital imaging
Chapter 9. Photoacoustic imaging
Chapter 10. Raman imaging
Chapter 11. Optical coherence tomography
Chapter 12, Optical clearing agents based imaging
Chapter 13. Autofluorescence tissue imaging and quantification
Chapter 14. In vivo flow cytometer

Summary: This textbook serves as a comprehensive manual on Optics that includes both didactics and assessment questions in an easy-to-read format. It provides an educational and entertaining resource that reinforces the relevance of the subject matter to modern clinical and surgical ophthalmology practice. The book offers a one-stop compendium for students studying for certification exams and for practicing ophthalmologists to review and learn Optics that will have relevance to their day-to-day practice. Chapters are written in a teaching-oriented style and include hi-yield summaries, 375+ original figures, and 190+ review questions. The book is divided into three areas of focus: Written Exam Preparation Oral Exam Preparation and Clinical Practice Ophthalmic Optics for Surgical Practice Optics for the New Millennium is a must-have resource for ophthalmology residents as well as practicing ophthalmologists with clinical, surgical and testable relevance.

Contents:
Section I: Ophthalmic Optics For Written Exam
Chapter 1. Geometric Optics
Chapter 2. Prisms
Chapter 3. Lenses
Chapter 4. Mirrors and Combined Systems
Chapter 5. Power of Lenses in Different Media
Chapter 6. Lens Effectivity
Chapter 7. Schematic Eye
Chapter 8. Magnification and Telescopes
Chapter 9. Accommodation and Presbyopia
Chapter 10. Spherocylindrical Lenses
Chapter 11. Astigmatism
Chapter 12. Glasses for Written Exams
Chapter 13. Contact Lenses for Written Exams
Chapter 14. Physical Optics and Advanced Optical Principles
Section II: Ophthalmic Optics for Oral Exams and Clinical Practice
Chapter 15. Glasses in Clinical Practice
Chapter 16. Construction of Glasses
Chapter 17. Optical Instruments
Chapter 18. Visual Activity Testing and Assessment
Chapter 19. Low Vision and Vision Rehabilitation
Chapter 20. Contact Lenses in Clinical Practice
Chapter 21. Clinical Problems with Optics and Refractive Manifestations
Chapter 22. Optics for Clinical and Surgical Management of Strabismus
Chapter 23. Pediatric Optics
Chapter 24. Myopia Control
Chapter 25. Optics in Micro-Gravity and Zero-Gravity Conditions
Section III: Ophthalmic Optics for Surgical Practice
Chapter 26. Preoperative Optics for Cataract Surgery
Chapter 27. What's on the Menu: An Overview of IOLs and Relevant Optics
Chapter 28. Intraoperative Optics for Cataract Surgery
Chapter 29. Postoperative Optics for Cataract Surgery
Chapter 30. Optics for Refractive Surgery.

Summary: This book is a concise guide to the correct diagnosis and management of dental pain and anxiety. It covers psychology theories about pain, dentine sensitivity, hypersensitivity and cracked tooth syndrome. Chronic pain, temporomandibular disorders and local anesthesia are discussed, and optimal medical and perioperative pain management explained. The book is written by leading experts in the field and provides an up to date, pragmatic perspective on optimizing pain and anxiety management in the dental patient. It includes an overview of differential diagnoses of non-odontogenic orofacial pain. As well as meeting the needs of dentists, the book will be a "must read" for whole dental team.

Contents:
Intro to Pain
The Psychology Theories of Pain
Psychological Interventions for Persistent Pain
An Overview of Dental Anxiety and its Non-Medical Management
Medical Management of Anxiety
Perioperative Pain Management of the Dental Patient
Optimal Local Anaesthesia for Dentistry
Temporomandibular Disorder for the General Dental Practitioner
Chronic Pain and Overview or Differential Diagnoses of Non-Odontogenic Orofacial Pain
Dental Pain: Dentine Sensitivity, Hypersensitivity and Cracked Tooth Syndrome.

Contents:
Strategies to maintain fertility in young breast cancer patients / Elizabeth S. Constance, Molly B. Moravek and Jacqueline S. Jeruss
Adjuvant endocrine therapy / Rena Shah and Ruth M. O'Regan
Breast cancer screening : the debate that never ends / Sarah M. Friedewald
Management of the axilla in early breast cancer / Monica G. Valero and Mehra Golshan
Is DCIS overrated? / Joshua Feinberg, Rachel Wetstone, Dana Greenstein and Patrick Borgen
Readdressing the role of surgery of the primary tumor in de Novo stage IV breast cancer / Seema Ahsan Khan and Elizabeth S. M. DesJardin
Advancements and personalization of breast cancer treatment strategies in radiation therapy / Meena S. Moran
Multi-gene panel testing in breast cancer management / Christos Fountzilas and Virginia G. Kaklamani
Advances in endocrine therapy for postmenopausal metastatic breast cancer / Lisa E. Flaum and William J. Gradishar
Immune checkpoint blockage for breast cancer / April Swoboda and Rita Nanda
Sexual function post-breast cancer / Lauren Streicher and James A. Simon.

Summary: Many individuals worldwide initiate sexual activity during their adolescent and young adult (AYA) years and are in need of safe and effective contraceptive services. Because of their safety profile, ease of use, and privacy many international professional organizations recommend that long-acting reversible contraception (LARC), including intrauterine devices (IUDs), be included in contraception discussions with AYAs. IUDs are particularly advantageous because these methods are safe and highly effective (>99% efficacy), are easy to keep confidential because they are often undetectable to others, and do not require daily adherence or frequent visits for refills. Despite significant evidence of their safety, acceptability, and effectiveness, among adolescents and AYAs, IUDs remain underutilized in this population. Written by experts in the field, Optimizing IUD Delivery for Adolescents and Young Adults provides a comprehensive framework that examines the history of IUDs, counseling, initiation, placement, and follow-up techniques that are unique to AYA populations. The text closes with resource chapters, including, expert clinical pearls for AYA IUD delivery, how to access IUD training, and information on IUD billing and reimbursement. In an effort to integrate the voice of youth, clinical case examples and patient stories are utilized throughout to provide both a clinical grounding for each chapter and context within which to apply the chapter material.

Contents:
The Intrauterine Device and Adolescents – History and Present
Making Your Office Accessible for Adolescents and Young Adult IUD Services
Types of IUDs and Mechanism of Action
Addressing IUD Efficacy, Eligibility, Myths, and Satisfaction with Adolescents and Young Adults
IUD Counseling: Whats Choice Got to Do With It?
Just Do it: The When and How of IUD Insertion
Consenting and Pre-Procedural Counseling for IUD Insertion: What to Expect and What to Talk About
Integrating IUD Provision Into Your Practice: Site Preparedness, Staff Training, and Procedural Steps
Pharmacologic Approaches to Pain Management with IUD Insertion
Nonpharmacologic Approaches to Pain Management with IUD Insertion
Follow Up After IUD insertions: Managing IUD Expectations, Addressing Side Effects, and Providing Post-Insertion Counseling
Challenging IUD Procedures
Adolescent and Young Adult IUD Delivery in Non-Traditional Health Settings.

Contents:
Overview of the causes of suboptimal outcomes following cataract surgery : role of preoperative screening and adequate counselling / Samir Narang and Priya Narang
Tear film and corneal disorders / Laura M. Periman and Priya Narang
Postrefractive intraocular lens power calculation : choosing the right nomogram / Aazim A. Siddiqui and Uday Devgan
Residual refractive error / Edward E. Manche and Lisa Y. Chen
Posterior corneal astigmatism : basics and clinical implications / Fernando Antonio Faria-Correia, José Carlos Ferreira Mendes, Jaime Aramberri, and Renato Ambrósio Jr.
Considerations in cataract surgery following postrefractive error correction / William Trattler
Corneal-based procedures : astigmatic keratotomy, LASIK, PRK, and SMILE / Marcony Santhiago
Intraocular lens exchange / Thomas A. Oetting
Piggyback intraocular lens / Johnny L. Gayton, Riley N. Sanders, and Val Nordin Sanders
Toric intraocular lens / Eric Clayton Amesbury and Kevin M. Miller
Premium intraocular lenses and associated problems / Elizabeth Yeu and Mario J. Rojas
Dysphotopsias and surgical management / Samuel Masket and Nicole R. Fram
Bullous keratopathy and endothelial keratoplasty / Jonathan K. Kam and Jacqueline Beltz
Malpositioned intraocular lens and capsular bag : intraocular lens complex issues / Amar Agarwal
Posterior capsular rupture and intraocular lens implantation / Priya Narang
Miloop : micro-interventional, phaco-free, lens fragmentation / Tsontcho Ianchulev and Susan Macdonald
Keratoconus and cataract surgery / Arthur B. Cummings and Sheraz Daya
Bilensectomy (phakic IOL explantation with coincidental cataract surgery and IOL implantation) / Veronica Vargas Fragoso and Jorge L. Alió
Cystoid macular edema and management / J. Fernando Arevalo, Carlos F. Fernández, and Fernando A. Arevalo
Endophthalmitis, toxic anterior segment syndrome, and vitritis / Andrzej Grzybowski and Magdalena Turczynowska
Intraoperative aberrometry / Kathryn M. Hatch
Futuristic approach and advancements / Gary Wörtz
Telescopic intraocular lenses / Isaac Lipshitz and Amar Agarwal.

Summary: This practical, engaging book provides concise, real life-tested guidance to healthcare teams concerned with widely reported and incentivized hospital quality and safety metrics, offering both a conceptual approach and specific advice and frameworks for reviewing quality and safety numerator events, from the perspective and experience of clinicians and administrators working within the Ochsner Health System. The text opens with the rationale for closely managing widely (including publicly) reported hospital patient quality and safety measures. Attention is given to the financial implications of quality performance, with respect to both penalties and payment incentives used by payer organizations. It then reviews the major public ratings and their relevant methodologies, including CMS, AHRQ and NSHN. In addition, it addresses ratings by proprietary organizations that have a large member clientele, such as Vizient, USNews, Leapfrog, Healthgrades, CareChex and others. Each metric - for example, the AHRQ Patient Safety Indicators (PSIs), and other metrics such as readmission rate, risk adjusted complications, hospital-acquired conditions and mortality - is addressed in a stand-alone chapter. For each, the importance, approach to review, opportunity for optimization, and engagement of healthcare staff are reviewed and discussed. Overall, this book forefronts the benefits of a collaborative approach within a health system. The concurrent review process, multidisciplinary collaboration among quality improvement, clinical documentation, coding and medical staff personnel are all emphasized. Also described in detail is the approach to and specific opportunities for medical staff education and engagement. Additional key topics include Engagement of the Medical Staff and House Staff (i.e., residents and other trainees), Futile Care, Surgical Quality Improvement (NSQIP), Nursing Provider Partnership, and Translation of Data Review to Successful Performance Improvement. Specialty chapters on pediatric, neurologic and transplant quality metrics are also included.

Summary: This book by Madbak and Dangleben has collated lot of information that has been presented and published in many disparate arenas into a single easy to read source. In an area where there is more experience and ℓ́ℓfavorite techniquesℓ́ℓ than true evidence based answers, they provide a wealth of information along with outstanding photographic support that makes this an excellent resource for all surgeons caring for this population. Similar to many things in life, when treating patients with the open abdomen one size or methodology does not fit all and this book will assuredly contain at least one possible answer to your patientℓ́ℓs problem. One of the more unique aspects of this textbook is its detailed ℓ́ℓHow toℓ́ℓ approach for the wide variety of techniques utilized in the management of the open abdomen. While there may be no consensus as to what constitutes the optimal management of the open abdomen, this book articulates a number of options and their advantages. Most importantly, it provides high quality photographs that enhance the step by step ℓ́ℓHow toℓ́ℓ approach of the text. More recent developments including using biologic mesh, implementing complex abdominal wall reconstruction and utilizing minimally invasive endoscopic techniques are described. This book is not only appropriate for all practicing surgeons that deal with this complex issue, but is also relevant for residents and fellows who are just getting their first exposure to open abdomens.

Contents:
Optical control of protein activity and gene expression by photoactivation of caged cyclofen / Fatima Hamouri, Weiting Zhang, Isabelle Aujard, Thomas Le Saux, Bertrand Ducos, Sophie Vriz, Ludovic Jullien, and David Bensimon
Reversible optogenetic control of protein function and localization / Daniel Z. Wu, Rachel M. Lackner, Chanat Aonbangkhen, Michael A. Lampson, and David M. Chenoweth
Protocols for the generation of caged guideRNAs for light-triggered RNA-targeting with SNAP-ADARs / Alfred Hanswillemenke and Thorsten Stafforst
Combinatorial control of gene function with wavelength-selective caged morpholinos / Sankha Pattanayak, Luis Angel Vázquez-Maldonado, Alexander Deiters, and James K. Chen
Phosphodiester photo-tethers for the (multi-)cyclic conformational caging of oligonucleotides / Patricia Müller, Patrick Seyfried, Anton Frühauf, and Alexander Heckel
Chemical modification of proteins with photocleavable groups / Karthik Nadendla, Bhagyesh Sarode, and Simon H. Friedman
Intramolecular cross-linking of proteins with azobenzene-based cross-linkers / Nobuo Yasuike, Huixin Lu, Peng Xia, and G. Andrew Woolley
Ruthenium-cross-linked hydrogels for rapid, visible-light protein release / Teresa L. Rapp and Ivan J. Dmochowski
Chromatically independent, two-color uncaging of glutamate and GABA with one- or two-photon excitation / Stefan Passlick and Graham C.R. Ellis-Davies
DIY optogenetics : building, programming, and using the Light Plate Apparatus / Karl P. Gerhardt, Sebastian M. Castillo-Hair, and Jeffrey J. Tabor
Pulsatile illumination for photobiology and optogenetics / Julia Dietler, Robert Stabel, and Andreas Möglich
Genetically encoding photoswitchable click amino acids for general optical control of conformation and function of proteins / Christian Hoppmann and Lei Wang
Light-activation of Cre recombinase in zebrafish embryos through genetic code expansion / Wes Brown and Alexander Deiters.

Summary: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a "must read" for all involved in research in any way related to optogenetics.

Contents:
Part 1. Light-sensitive channels and transporters
1. History and Perspectives of Light-Sensing Proteins
2. Phototactic behavior of Chlamydomonas
3. Structure-Functional Analysis of rhodopsin light sensors
4. Molecular Dynamics of Channelrhodopsin
5. Photochemistry of Halorhodopsin
6. Spectroscopic Dynamics of Microbial Rhodopsins
7. Molecular Engineering of Retinylidene Proteins
8. A new optogenetic tools from deep ocean
Part 2. Light-sensitive signaling molecules
9. Biology of Light-Sensing Proteins in Plants and Microorganisms
10. Optogenetic Potentials of Diverse Animal Opsins
11. Enzyme rhodopsins
12.Optogenetic photoswitches
13.Genetic, biochemical and biophysical studies on flavoprotein photoreceptors
Part 3. Optogenetics in Biological System
14. General Description: Future Prospects of Optogenetics
15. Optogenetic Manipulation and Probing
16. Visualization and Manipulation Signaling Molecules In Vivo
17. Optical Manipulation of Gene Expression
18. Optical Manipulation of Intracellular Signaling
19. Single Molecule Optogenetics
20. Bioluminescence Imaging
21. Luminescence Optogenetics
22. Optogenetic Imaging of Protein Activity in the Synapse Using 2-Photon Fluorescence Lifetime Imaging Microscopy
23. Optogenetics in Drosophila
24. Optogenetics in Caenorhabditis elegans
25. Optogenetics in zebrafish
26. Optogenetics Research Using the Mouse as a Model System
27. Optogenetics Research Using Rat
28. Optogenetics Research Using Primates
29. Organelle Optogenetics
Part 4. Optogenetics in Neuroscience
30. Neuroscientific Frontline of Optogenetics
31. Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics
32. Multiscale neural activity in the behaving brain
33. Optogenetic Analysis of Striatal Connections to Determine Functional Connectomes
34. Optogenetics for the Behavior Manipulation of Non-human Primates
35. Activity Regulation in the Study of Neural Plasticity
36. Optogenetic Control of Synaptic Plasticity
37. Casting Light on the Role of Glial Cells in Brain Function
38. Optogenetic manipulation of Respiratory Rhythm
39. Optogenetic mapping of brain circuitry
40. In vivo imaging of Arc transcription
41. Neural Circuits for the Formation and Retrieval of Episodic Memories
Part 5. Medical Optogenetics
42. Medical Optogenetics, Overview
43. Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders
44. Gene Therapy Using Channelrhodopsins to Treat Blindness
45. Optogenetic Approaches to Restoring Intrinsic Visual Processing Features in Retinal Ganglion Cells
46. Application of optogenetics to epilepsy research
Part 6. Opto-electro-nano Technologies for Optogenetics
47. CMOS-Based Neural Interface Device for Optogenetics
48. OLED System for Optogenetics
49. Micro-imaging probes, Opto-electrodes, and Virtual Reality Systems for Optogenetics
50. Upconversion
51. Optical probes for in vivo optogenetics.

Summary: Oral, Head and Neck Oncology and Reconstructive Surgery is the first oral and maxillofacial surgery (OMS) text to provide you with a system for managing adult oral, head and neck cancers and reconstructive cranio-maxillofacial surgery. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck/cranio-maxillofacial surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are accompanied by videos of surgical procedures that are easily accessible on mobile devices.

Summary: "Oral and Maxillofacial Pathology, 5th Edition guides you through the wide variety of diseases that may affect the oral and maxillofacial region. More than 1,500 radiographs and full-color clinical photos bring various lesions and conditions to life. Updates in this edition include coverage of the latest advances in oral squamous cell carcinoma treatment, HPV, and molecular pathology, along with revised content throughout. Well-known oral pathology educators Brad Neville, Douglas Damm, Carl Allen, and Angela Chi, bring you up to date on the latest concepts of pathogenesis and disease management in the care of patients with oral disease."--Provided by publisher.

Contents:
Developmental Defects of the Oral and Maxillofacial Region
Abnormalities of Teeth
Pulpal and Periapical Disease
Periodontal Diseases
Bacterial Infections
Fungal and Protozoal Diseases
Viral Infections
Physical and Chemical Injuries
Allergies and Immunologic Diseases
Epithelial Pathology
Salivary Gland Pathology
Soft Tissue Tumors
Hematologic Disorders
Bone Pathology
Odontogenic Cysts and Tumors
Dermatologic Diseases
Oral Manifestations of Systemic Diseases
Facial Pain and Neuromuscular Diseases
Forensic Dentistry
Differential Diagnosis of Oral and Maxillofacial Diseases.

Contents:
V. 1. Profession and practice of oral and maxillofacial surgery, anesthesia and pain control, dentoalveolar surgery, implant surgery / volume editor, Raymond J. Fonseca ; section editors, Michael P. Powers, David E. Frost, Bach Le
v. 2. Trauma, surgical pathology, temporomandibular disorders / volume editor, Raymond J. Fonseca ; section editors, Eric R. Carlson, Raymond J. Fonseca, Gregory M. Ness
v. 3. Orthognathic surgery, esthetic surgery, cleft and craniofacial surgery / volume editor, Raymond J. Fonseca ; section editors, Timothy A. Turvey, Bernard J. Costello, Ramon L. Ruiz.

Summary: This book is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world.

Contents:
Oral and Maxillofacial Surgery in India. How did we get here and where are we going?
Pre-Operative Evaluation & Investigations
Management of Medically Compromised Patients
Management of Medical Emergencies
Local Anaesthesia
Oral and Maxillofacial Surgery
Ambulatory Anesthesia Model and Training
Anesthesia for OMFS
Radiology for the Oral and Maxillofacial Surgeon: The Essentials
Sterilisation and Operating Room Protocols
Pharmacotherapy in OMFS
Wound closure and Suturing Methods
Management of the Post operative OMFS Patient
Principles and Techniques of Exodontia
Management of the Impacted tooth: A : Third Moalr impactions
Canine Impactions
Endodontic surgery
Pre prosthetic Surgery
Basic Implantology
Bone Augmentation Procedures in Implantology
Odontogenic Infections - General Principles
Space Infections
Osteomyelitis /ORN/ MRONJ
Maxillary Sinusitis
Management of Oro Antral Communications & Fistulae
Trigeminal Nerve Injuries
Trigeminal Neuralgia
Cysts of the OMF region
Odontogenic Tumours
Reactive Lesions of the Oro Maxillofacial Region
Fibro Osseous Lesions
Vascular Anomalies of the Oro Maxillofacial Region
Non-Surgical Modalities of Facial Rejuvenation & Aesthetics
Botox & Fillers
Hair Transplant
Ear Reconstruction
Management of Scars
Face Lifts
Rhinoplasty
Lasers in OMFS
Peizo Surgery in OMFS
Role of Computer-assisted Navigation Surgery in Oral and Maxillofacial Surgery
Human Factors and Reducing Medical Error.-Setting up an OMFS Facility
Legal Issues in OMFS
Research & Publication
Salivary Gland Disorders
Salivary Gland Tumours
Obstructive Salivary Gland disease and Sialendoscopy
Primary Assessment & Care of the Maxillofacial Trauma Patient
Soft Tissue Injuries
Dento Alveolar Fractures & Wiring techniques
Plating Systems & Principles of ORIF
Mandibular Fractures
Condylar Fractures of the Mandible
Intraoral Endoscopic Approach for Condylar Fractures
Maxillary Fractures
Zygomatic Complex Fractures
Orbital Fractures
Frontal & NOE Fractures
Gunshot Injuries
Panfacial Trauma
Residual Deformities
MPDS
Internal Derangements of TMJ
TMJ Ankylosis
Dislocation/ Subluxation
Alloplastic Reconstruction
Diagnosis & Planning
Facial Asymmetry
Mandibular Procedures
Maxillary Procedures
SFOA
OSAS
Complications in Orthognathic Surgery
Cleft Lip
Cleft Palate
Alveolar Bone Grafting
Cleft Maxillary Hypolplasia
Cleft Rhinoplasty
Transport Distraction Osteogenesis
Distraction Osteogenesis: Craniofacial , Pediatric
Rare Facial Clefts
Hemifacial Microsomia / Treacher Collins
Craniosynostosis
Pre malignant Lesions and Conditions
Carcinoma Diagnosis & Treatment Planning
Principles of Surgical Management of Oral Cancer
Sarcoma
Adjunctive Therapy
Access Surgeries/Osteotomies
Soft Tissue Reconstruction
Hard Tissue Reconstruction.

Summary: This book is a detailed guide to the identification and appropriate management of patients who represent a high risk when performing oral and maxillofacial surgery or the complex procedures that are increasingly attempted by general dental practitioners. Emphasis is also placed on evaluation of the medically compromised patient for outpatient anesthesia. The book is systematically divided into a series of chapters focusing on the medical conditions most commonly encountered in practice and on current treatment standards. Each chapter outlines evidence-based guidelines for evaluation of patients to establish whether they are suitable candidates for oral surgery. In addition, commonly encountered clinical management dilemmas are thoroughly explored. Lastly, this book will enable the provider to understand whether there is a need to seek medical clearance before proceeding. It will be an invaluable guide for both oral and maxillofacial surgeons and general dentists.

Contents:
Introduction
Oral and Maxillofacial Surgery for the Cardiovacsular Patient
Oral and Maxillofacial Surgery in Patients with Respiratory Disease
Oral and Maxillofacial Surgery and Liver Diseases
Oral and Maxillofacial Surgery for the Renally Compromised Patient
Oral and Maxillofacial Surgery for the Immune Compromised Patient
Oral and Maxillofacial Surgery and Metabolic Disorders
Oral and Maxillofacial Surgery and Psychiatric and Behavioral Disorders
Oral and Maxillofacial Surgery for the Substance Abuse Patient
Oral and Maxillofacial Surgery and Hematologic Diseases
Oral and Maxillofacial Surgery and Neurological Diseases
Management Dilemmas in Oral and Maxillofacial Surgery.

Summary: Given the amount and complexity of information surrounding the the target specific oral anticoagulants a lengthy didactic educational format has the potential to be overwhelming to the reader and difficult to translate and apply to direct patient care. The proposed book will educate clinicians utilizing a series of clinical cases to simultaneously develop the readers' knowledge base, problem-solving skills, and practically apply their new knowledge to a variety of clinical situations. These will be short focused case presentations that provide critical information and pose questions to the reader at key points in the decision making process. The cases will be relevant to what clinicians will encounter not only on a daily basis, but also reflective of scenarios that clinicians will not encounter regularly, but that they will have to act upon (e.g. a bleeding patient, patient scheduled for elective or emergent procedure, patient with changing renal function, patient on drugs that have a plausible yet unstudied drug interaction with a target specific oral anticoagulant etc). Included in the case studies will be evidence-based discussions (with appropriate references) that provide immediate feedback on the different treatment alternatives that were offered. The case studies will be designed to instruct the reader how to select and effectively utilize the most appropriate agent for a given clinical scenario. They will focus on key features of the target specific oral anticoagulants, what they have in common, how they are unique from each other, as well as illustrating the clinical decision process one should take when selecting an agent or managing a patient already receiving one of the target specific oral agents.

Contents:
Drug pharmacokinetics and toxicokinetics
GIT anatomy and physiology and drug oral bioavailability : impact of species differences
Drug routes of excretion
Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion
Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect
Impact of intestinal efflux transporters on oral absorption
Impact of influx transporters on drug
Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery
In vitro and in situ approaches to measure intestinal permeability and efflux transporters
In silico approaches to predict intestinal permeability
In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption
In vitro approaches to assess haptic metabolism and first pass effect
The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.

Summary: "Biofilms are the most obvious and essential etiologic factors for all oral diseases with the exception of trauma and malignancies. This volume on "biofilms" looks at this structure from various angles. It provides analysis on various cariologic, endodontologic, periodontal, and peri-implant aspects, as well as those of dental unit water lines. The book is recommended for all dental students, graduate students, and biologically oriented dental clinicians"-- Provided by publisher

Contents:
Biofilms / Eick, S.
Biofilms in Dental Unit Water Lines / Dahlen, G.
The Impact of the pH Value on Biofilm Formation / Schultze, L.B., Maldonado, A., Lussi, A., Sculean, A., Eick, S.
Biofilm Models to Study the Etiology and Pathogenesis of Oral Diseases / Thurnheer, T., Paqué, P.N.
Biofilm Models for the Evaluation of Dental Treatment / Eick, S.
Cariogenic Biofilms and Caries from Birth to Old Age / Astasov-Frauenhoffer, M., Kulik, E.
Supragingival Biofilm : Toothpaste and Toothbrushes / Cvikl, B., Lussi, A.
Actual Concepts for Individual Interdental Biofilm Removal / Jentsch, H.F.R.
Arginine : A Weapon against Cariogenic Biofilm? / Eick, S., Lussi, A.
Oral Mouth Rinses against Supragingival Biofilm and Gingival Inflammation / Arweiler, N.B.
Peri-Implant Diseases : Characteristics of the Microbiota and of the Host Response in Humans
A Narrative Review / Schmid, E., Eick, S., Sculean, A., Salvi, G.E.
Mechanical Removal of the Biofilm : Is the Curette Still the Gold Standard? / Bastendorf, K.-D., Strafela-Bastendorf, N., Lussi, A.
Antibiotics against Periodontal Biofilms / Guentsch, A.
Effectiveness of Photodynamic Therapy in the Treatment of Periodontal and Peri-Implant Diseases / Sculean, A., Deppe, H., Miron, R., Schwarz, F., Romanos, G., Cosgarea, R.
New Bacterial Combinations in Secondary Endodontic Infections of Patients with a Recent Systematic Antibiotic Therapy / Al-Ahmad, A., Elamin, F., Gärttner, R., Anderson, A., Wittmer, A., Mirghani, Y., Hellwig, E.
Biofilms on Restorative Materials / Schmalz, G., Cieplik, F.
Halitosis / Ortiz, V., Filippi, A.
Biofilm and Orthodontic Therapy / Müller, L.K., Jungbauer, G., Jungbauer, R., Wolf, M., Deschner, J.
In vitro Activity of Oral Health Care Products on Candida Biofilm Formation / Katagiri, H., Stuck, N.-J., Arakawa, I., Nietzsche, S., Eick, S.

Summary: This book provides an up-to-date perspective on oral biofilms and dental materials, equipping readers with a sound understanding of their mutual interactions. Experts from across the world comprehensively describe the main strategies that can be followed when designing modern bioactive and biomimetic dental materials, bearing in mind the goal of reducing the occurrence of pathological conditions such as secondary caries and peri-implantitis. The background to the book is the rapid expansion in the use of nanotechnologies and modern techniques to achieve levels of performance of dental materials that were unthinkable even a few years ago. Whereas conventionally dental materials have been regarded as inert, an important paradigm shift is underway: now, these materials are being conceived as bioactive and biomimetic. Modern dental materials can produce a response by interacting positively both with the host and with the biofilm permanently colonizing hard and soft tissues of the oral cavity. These materials increasingly mimic the behavior of the tissues that they are replacing. In documenting the latest knowledge in the field, this book will be of value for both scientists in the fields of nanotechnology, biofilms and dental materials and interested clinicians.

Contents:
Introduction - A Paradigm Shift Towards Bioactivity
Oral Biofilms - What are They?
The Importance of the Salivary Pellicle
Oral Biofilms and Secondary Caries Formation
Bioreactors: How to Study Biofilms in vitro
Surface Properties of Dental Materials and Biofilm Formation
Complex Polymeric Materials and Their Interaction with Microorganisms
Effect of Oral Biofilms on Dental Materials: Biocorrosion and Biodeterioration
Considerations for Designing Next Generation Composite Dental Materials
Multifunctional Restorative Dental Materials: Remineralization and Antibacterial Effect
Dental Resin-based Materials with Antimicrobial Properties: Contact Inhibition and Controlled Release
Conclusion - Future Trends in Dental Materials.

Contents:
Preface
Section 1
Dentoalveolar, TMJ, Maxillofacial Infections, and Implantology
Chapter 1. Dentoalveolar
Chapter 2. Temporomandibular Joint Syndrome
Chapter 3. Management of Maxillofacial Infections
Chapter 4. Dental Implantology
Section 2
Orthognathic, OSA, Cosmetics, and Trauma
Chapter 5. Orthognathic and Obstructive Sleep Apnea
Chapter 6. Cosmetic Surgery
Chapter 7. Maxillofacial Trauma
Section 3
Pathology and Reconstruction
Chapter 8. Oral Pathology
Chapter 9. Reconstruction
Chapter 10. Cleft Lip and Palate
Section 4
Anesthesia and Medicine
Chapter 11. Outpatient Anesthesia
Chapter 12. Liver Disease
Chapter 13. Cardiovascular Disease
Chapter 14. Pulmonary Diseases
Chapter 15. Renal Disease
Chapter 16. Hematological Disease
Chapter 17. Connective Tissue Disorder
Chapter 18. Endocrine Disease
Chapter 19. Neurological Disorders
Chapter 20. Electrolyte and Acid-Base Disturbances
Chapter 21. Psychiatric Disease
Chapter 22. Pregnancy
Chapter 23
Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS)
Chapter 24. Substance Abuse
Chapter 25. Medical Emergencies
Chapter 26. Medicine Case 1
Chapter 27. Medicine Case 2.

Summary: Oral cancer is frequently diagnosed late, when the disease has advanced with lesions that are large and deeply invasive and with metastasis to regional lymph nodes, leading to increased mortality. Moreover, late diagnosis and treatment often result in considerable morbidity of oral and maxillofacial structures and poor appearance and function following therapy. This book provides head and neck oncologists, oral oncologists, oral and maxillofacial surgeons, medical oncologists, dentists and other members of dental teams furnishing supportive care with a systematic review of recent diagnostic and therapeutic advances in oral cancer. The various authoritative chapters are prepared by specialists who are active leaders in each basic and clinical field. All chapters address individual and collective issues that arise in managing oral cancer patients with difficult treatment problems and provide insight into the multiple valid management approaches available. The authors offer an extensive source of information about oral cancers and encourage the clinician to be flexible and innovative, giving physicians and medical personnel the background information to make the best, educated, responsible decisions for individual patients.

Contents:
1. Epidemiology of the Oral Cancer
2.Surgical Pathology of Oral Cancer
3. Molecular Biology of the Oral Cancer
4. Oral Potentially Malignant Disorders
5. Imaging and Classification of Staging
6. Clinical Evaluation and Differential Diagnosis
7. Surgical Approaches to the Oral Cavity
8. Management of the Neck
9. Oral and Maxillofacial Reconstruction
10. Prosthetic Reconstruction for the Oral Cancer Patients Using Dental Implants
11. Radiotherapy
12. Systemic Chemotherapy
13. Chemoradiotherapy Using Retrograde Superselective Intra-Arterial Infusion for Advanced Oral Cancer
14. Oral and dental healthcare for oral cancer patients: planning, management, and dental treatment
15. Management of Speech Disorders Following Treatment for Oral Cancer
16. Management of Dysphagia Following Treatment for Oral Cancer
17. QOL Management in Oral Cancer Patients
18. Palliative Care for Oral Cancer.

Summary: "Oral Cancer: Evaluation, Therapy, and Rehabilitation edited by prominent Johns Hopkins clinicians and educators Carole Fakhry, Karen Pitman, Ana Kiess, and David Eisele provides a comprehensive, state-of-the-art review on the diagnosis and management of oral cancer. This unique resource fills a void in the literature by exploring surgical and reconstructive issues specific to each subsite of the oral cavity. Important pre- and post-treatment evaluations by dental, speech-language pathology, and the oncologic care team are reviewed"-- Provided by publisher.

Summary: "Preface-- Operative treatment for oral cancer is one of the most challenging fields in whole surgery. The perioral region is the only area of the body containing all types of tissue: muscle, bone, cartilage, skin and mucosa. Because of this unique anatomy, ablative tumor surgery and reconstructive surgery remain very complex. On the one hand, the surgeon has to possess elaborate skills in handling the soft tissue, dealing with microvascular techniques and managing bone treatment including osteosynthesis. On the other hand, he has to prepare defined strategies to anticipate any upcoming surgical problem. As there is an overwhelming repertoire of ablative and reconstructive procedures, it is hard for students, residents and young surgeons to find the right way to "survive in the operative jungle." This book concentrates on key procedures that offer young surgeons the possibility to solve almost any case of oral cancer. Basic principles are didactically edited in series of pictures and/or diagrams. Traditional approaches are combined with innovative techniques. Anatomical introductions connect previous knowledge with the surgical procedures. Additionally, historic landmarks and recommendations regarding to the techniques are given in an informational, sometimes anecdotic style. The compact and concise character of the book should enable the resident to study, prepare and recapitulate all issues regarding oral cancer surgery in a short time. Marco Kesting 2014 "--Provided by publisher.

Contents:
Lead identification/optimization / Dr. Mei Wong And Dr. Mark Mcallister
Oral drug formulation development in pharmaceutical lead selection stage / Shayne Cox Gad
Bridging end of discovery to regulatory filing : formulations for IND- and registration-enabling nonclinical studies / Evan A. Thackaberry
Planning the first clinical trials with clinical manufacturing organization (CMO) / Elizabeth Kwong and Caroline McGregor
Formulation strategies for high dose toxicology studies : case studies / Dennis H. Leung, Pierre Daublain, Mengwei Hu, Kung-I Feng
Formulation, analytical and regulatory strategies for first in human clinical trials / Lorenzo Capretto, Gerard Byrne, Sarah Trenfield, Lee Dowden, and Steven Booth.

Summary: This book provides a comprehensive review of the assessment and management of older peoples oral health care needs. Discussing recent initiatives to emphasize oral health promotion and prevention, the book describes improvements in pharmacological and non-pharmacological approaches for special populations in geriatrics and illuminates the role of barriers to oral health care for older people. Divided into three sections, the book first explores aging and oral health, including age-related changes, epidemiology, nutrition, dysphagia, aspiration pneumonia, xerostomia and hyposalivation, management of periodontal disease and caries, systemic diseases that influence oral health, and considerations for chronic orofacial pain. The second section illuminates the ways in which frailty and other geriatric syndromes influence oral health care in older adults with a special focus on frailty, dementia, delirium and depression, and the delivery of oral health care to vulnerable geriatric populations in long-term care, home care, palliative care, and hospice. Lastly, the book addresses inequalities in the oral health of older minority populations, the disproportionate burden of oral disease and tooth loss, the contribution of these issues to further complications in comorbidities, the association of extended health literacy and periodontal disease, and the social and cultural conditions that might be altered or improved by healthcare programs and health policies. Oral Health and Aging is a useful book written by an international group of experts and designed to educate geriatricians, primary care physicians, nurses, dentists, dental hygienists, speech and language pathologists, dietitians, and health policy advocates.

Contents:
Age-Related Changes in Oral Health
Epidemiology of Oral Conditions in Older Populations
Nutrition and Oral Health in Older Adults
Swallowing, Dysphagia, and Aspiration Pneumonia
Xerostomia and Hyposalivation in Older Adults
Management of Periodontal Disease in Older Adults
Caries Management and Restorative Dentistry in Older Adults
Systemic Disease that Influences Oral Health
Oral Health and the 3 Ds: Dementia, Delirium and Depression
Oral Care in Long Term Care Settings
Oral Health Care for Patients Receiving Palliative Care or Hospice
Ethical Considerations in Geriatric Dentistry
Health Disparities and Older Adults
Physical Frailty and Oral Health
The Role of Oral Health Literacy in Shared Decision Making
Barriers to Accessing Dental Care for Older Adults.

Summary: This book aims to provide the dental team with an improved understanding of management of the oral health needs of the ageing population, in whom increasing cognitive, medical and physical disabilities impact significantly on oral health and dental care needs. All significant aspects of caring for older people are covered. The nature and implications of changing demographics are explained and information provided on common medical co-morbidities and the impact of cognitive conditions, including dementia, on dental treatment. The changing pattern of dental disease in older people is clearly described, with explanation of the consequences of these changes for periodontics, endodontics, prosthodontics, and implantology. Advice is given on considerations to be borne in mind during treatment planning, including the importance of prevention and utilization of dental care professionals. Provision of care for older people under general anaesthesia or sedation and domiciliary care are also covered. The book is written by specialist practicing clinicians and delivers information in an accessible way with a person-centered approach.

Contents:
Introduction Why are the Needs of the Older Patient Different?
Changing Demographics of Ageing and the Implications - Relationship to General Health and Well-Being
Lived Experiences of Ageing and Quality of Life
Medical Complications in the Older Population
Cognitive Impairment and Dementia in the Older Population
Dental Changes with Increasing Age
Dental Treatment of Older People
Surgical Management in Older People Including Those on Bisphosphonates/Anticoagulants
Treatment Planning in Palliative Care
Providing Care under Local Anaesthesia, Sedation and General Anaesthesia
Dental Care in a Domiciliary Setting
Oral Care and Prevention
Research in Older People.

Summary: This textbook is exceptional in its coverage of modern theories on the patient-centered approach to communication, preventive dentistry, and dental anxiety. It provides the knowledge and tools required in order to implement a trauma-sensitive approach that will enhance the treatment experience for both the patient and the dental practitioner. General psychological aspects of dentistry and behavior management in patients who experience dental fear, anxiety, and pain are considered in detail. Extensive attention is devoted to the effective delivery of preventive care and dental treatment in a wide range of specific patient groups, including fearful and abused children and patients suffering from depression, personality disorders, psychosis, substance abuse disorders, and eating disorders. The importance of interdisciplinary cooperation and self-care in the dental clinic is also discussed. The book is an international collaborative effort between dentists and psychologists who draw on scientific research as well as their personal experiences in clinical practice. It is an excellent educational resource and will help readers to solve challenges in their own clinical settings. .

Contents:
Part I Basic oral health psychology
Ch 1: Basic oral health related psychology
Ch 2: The importance of trauma-sensitive care
Ch 3: Pain
Ch 4: The importance of a safe relationship with dental patients
Ch 5: Oral health literacy
Ch 6: Communication in dentistry - The Four Habits Model
Ch 7: Behavioural change
Ch 8: Self-determination theory (SDT)
Part II Children
Ch 9: Positive encounters for children to prevent dental anxiety; theory and practice
Ch 10: Family violence and child maltreatment
Part Back matter: Voice of Children
Part III Dental anxiety
Ch 11: Understanding development and persistence of dental anxiety
Ch 12: Psychological prevention and management of dental anxiety
Ch 13: Dentist-administered CBT-treatment for dental anxiety
Ch 14: Blood-, Injury- and Injection phobia
Part Back matter: Voice of dental anxiety patients
Part IV Patients with complex reactions and co- morbidity
Ch 15: People with mental disorders in the dental clinic
Ch 16: How to deal with gagging
Ch 17: Child sexual abuse and oral health challenges
Ch 18: Providing dental care to torture survivors
Ch 19: The psychosocial impacts of orofacial features - with examples from orthognathic surgery
Part Back matter: Voice of CSA survivors
Part V Professionalism
Ch 20: Dental professionalism and professional behaviour in practice and education
Ch 21: Living in a golden cage? Work stress, burnout risk, and engagement in dental practice; background and prevention
Ch 22: Working in partnership for better oral health care.

Summary: This book is an up-to-date guide to the diagnosis and management of the oral and orofacial conditions that may be encountered by dentists in primary care. Now in its fourth edition, the book has been completely restructured to provide a clinical signs and symptoms approach to disease that will enhance the ability of clinicians to establish the correct diagnosis. This is achieved by the lavish use of high-quality color clinical illustrations that cover the full spectrum of conditions seen most frequently in the dental surgery. In addition, contemporary information on patient management is presented in a clear and reader-friendly style. The book provides the clinician with an extremely useful tool for clinical diagnosis and delivery of the highest quality patient care. The contents are of direct relevance to all members of the dental team, not only in general practice but also in specialist settings.

Contents:
Diagnosis and Special Investigations in Oral Medicine
Oral Ulceration
Erythematous Conditions in Oral Medicine
White Patches in the Oral Mucosa
Orofacial Blistering Disease
Localised Mucosal Lesions
Pigmented Lesions in the Oral Mucosa
Orofacial Pain
Salivary Gland Disease
Medically Compromised Patients and Oral Diseases
Prescribing in Oral Medicine.

Summary: The first International Conference on Oral Mucosal Immunity and Microbiome (OMIM) aimed to highlight cutting-edge basic and translational research from an oral immunological and microbiological perspective. Oral diseases with a microbial etiology are the most prevalent chronic diseases of humans. Whilst not life-threatening, they can significantly compromise quality of life, are associated with increased risk for certain systemic diseases, and pose heavy financial burdens to national health systems. Hence, periodontal and peri-implant diseases, dental caries, root canal infections and mucosal infections are significant global public health problems. In this book global experts summarize and discuss the latest progress made in oral mucosal immunity and the oral microbiome. Target audience is basic and/or translational researchers with expertise in host immunity and microbiome research, and interest in oral health and disease. This volume provides a much needed quantum leap in the field, by joining forces to address gaps at the oral mucosal immunity-microbiome cross-talk.

Contents:
1. Advances in oral mucosal immunity and the microbiome
2. Trained innate immunity and its implications for mucosal immunity and inflammation
3. Signaling systems in oral bacteria
4. Origin of Th17 cells in Type 2 Diabetes-Potentiated Periodontal Disease
5. Gingival epithelial cell recognition of lipopolysaccharide
6. The relationship of Candida albicans with the oral bacterial microbiome in health and disease
7. A potential role of Phospholipase 2 group IIA (PLA2-IIA) in P. gingivalis-induced oral dysbiosis
8. Helicobacter spp. in experimental models of colitis
9. T Helper 17 cells as pathogenic drivers of periodontitis
10. Candida-bacterial biofilms and host-microbe interactions in oral diseases
11. Comparative analysis of gene expression patterns for oral epithelium-related functions with aging
12. Neutrophil interaction with emerging oral pathogens: a novel view of the disease paradigm
13. Biologically-defined or biologically-informed traits are more heritable than clinically-defined ones: the case of oral and dental phenotypes
.

Summary: The field of oral pathology is challenging for even the most highly trained pathologists. Comprehensive and richly illustrated, Oral Pathology, 3rd Edition, covers the full histologic range of presentation of oral disease, serving as a handy bench manual for the practicing pathologist signing out cases in the oral mucosa, salivary glands, and jawbones. Dr. Sook-Bin Woo, board certified in both oral pathology and oral medicine, draws on her extensive clinical experience to help you achieve diagnostic certainty for even the most complex lesions.

Contents:
Introduction
Developmental and congenital conditions
Noninfectious papillary lesions
Bacterial, viral, fungal, and other infectious conditions
Fibrous and gingival nodules
Vascular, neural, adipocytic, muscle, and myofibroblastic tumors
Ulcerative and inflammatory conditions
Granulomatous, immune-mediated, and autoimmune conditions
Pigmented lesions
Reactive keratotic lesions (nonleukoplakias)
Leukoplakia, erythroplakia, oral dysplasia, and squamous cell carcinoma
Inflammatory salivary gland disorders
Salivary gland neoplasms
Odontogenic cysts
Odontogenic tumors
Nonodontogenic cysts, cyst-like lesions, and myospherulosis
Nonodontogenic intraosseous tumors and inflammatory/reactive conditions
Hematolymphoid tumors of the oral cavity.

Contents:
Developmental and congenital conditions
Noninfectious papillary lesions
Bacterial, viral, fungal, and other infectious conditions
Fibrous, gingival, lipocytic, and miscellaneous tumors
Vascular, neural, muscle, and myofibroblastic tumors
Ulcerative and inflammatory conditions
Granulomatous, immune-mediated, and autoimmune conditions
Pigmented lesions
Reactive keratotic lesions (nonleukoplakias)
Leukoplakia, erythroplakia, oral dysplasia, and squamous cell
Carcinoma
Inflammatory salivary gland disorders
Salivary gland neoplasms
Odontogenic cysts
Odontogenic tumors
Nonodontogenic cysts, cystlike lesions, and miscellaneous entities
Nonodontogenic intraosseous cysts and tumors
Hematolymphoid tumors of the oral cavity / Olga K. Weinberg and Elizabeth A. Morgan.

Contents:
Clinical overview
Vesiculobullous diseases
Ulcerative conditions
White lesions
Red-blue lesions
Pigmented lesions
Verrucal-papillary lesions
Connective tissue lesions
Salivary gland diseases
Lymphoid lesions
Cysts of the jaws and neck
Odontogenic tumors
Benign nonodontogenic tumors
Inflammatory jaw lesions
Malignancies of the jaws
Metabolic and genetic diseases
Abnormalities of teeth.

Summary: This book provides a comprehensive overview of oral signs of a broad spectrum of systemic diseases including gastrointestinal, hematologic, and endocrine, in addition to infectious, nutritional, autoimmune, genetic and connective tissue diseases. An overview of associated key signs and salient features to look for on oral exam is provided as well as other clinical manifestations, differential diagnoses, and treatment recommendations. The mouth is an important anatomical location with a role in many critical physiologic processes that are frequently involved in conditions that affect the skin or other organ systems. In many instances, oral manifestations of a disease precede the appearance of other stigmata. Therefore, early recognition of oral signs and symptoms associated with underlying systemic diseases can be invaluable to the clinician in establishing a diagnosis and prompt initiation of therapy. This book, written for dermatologists, dentists, otolaryngologists, and oral medicine specialists, offers a structured approach to the therapy and management of diseases affecting the oral mucosa.

Contents:
Introduction
Oral signs of gastrointestinal disease
Oral signs of hematologic disease
Oral signs of endocrine and metabolic diseases
Oral signs of nutritional disease
Oral signs of connective tissue disease
Oral signs of vesiculobullous and autoimmune diesase
Oral signs of viral disease
Oral signs of bacterial disease
Oral signs of tropical, fungal, and parasitic disease
Oral signs of genetic disease.

Contents:
Infection control / Joseph E. Cillo, Jr., Jeffrey A. Elo, Alan S. Herford
Time out policy : correct patient, correct procedure, correct site / Deepak G. Krishnan, Riddhi Patel, Jeffrey A. Elo
Anatomy of local anesthesia in dentistry / Eric W. Baker
Common oral lesions / Elizabeth A. Andrews
Essentials of dental radiographic analysis and interpretation / Setareh Lavasani
Odontogenic infections / Chan M. Park, Benjamin R. Shimel, Jeffrey A. Elo, Alan S. Herford
Dentoalveolar surgery / Christopher F. Viozzi, Jeffrey A. Elo
Antibiotics / Rawle F. Philbert, Jeffrey A. Elo, Alan S. Herford, Ho-Hyun Sun, Christopher Yi
Pharmacology for the dental practitioner / Steven Fletcher, Jeffrey A. Elo, Alan S. Herford, Ho-Hyun Sun, Christopher Yi
Management of patients on anticoagulants and antiplatelet medications / David R. Cummings, Jeffrey A. Elo, Alan S. Herford, Ho-Hyun Sun, Christopher Yi
Hypertension guidelines / Ronald Caloss, Jeffrey A. Elo, Alan S. Herford
Management of medical emergencies / Brett J. King, Jeffrey A. Elo, Alan S. Herford
Management of the pregnant patient / Vincent Carrao, Jeffrey A. Elo, Alan S. Herford
Prescription writing / Edward T. Lahey, Jeffrey A. Elo, Alan S. Herford.

Summary: This book covers the advances in the field of ophthalmic plastic and orbital surgery. This booklet aims at educating the general and specialist ophthalmologists and residents about the various facets that this niche subspecialty has to offer in the future. The chapters cover the latest evidence-based approach in the diagnosis and management of various oculoplastic disorders. The chapters will be supplemented with ample illustrations and well labelled diagrams wherever necessary. Chapters include key topics such as imaging, orbital decompression, lacrimal surgery, and orbital trauma. Chapters on navigation-guided orbital surgery, oculo-facial aesthetics, socket surgery, and targeted therapies on peri-ocular and orbital malignancies complete the coverage. A special chapter on photographic documentation in Oculoplastics guides readers on how to capture the images for future reference and work. As part of the series "Current Practices in Ophthalmology" this volume is meant for residents, fellows-in-training, generalist ophthalmologists and specialists alike.

Contents:
Chapter 1: The Role of Photography in Oculofacial Aesthetics
Chapter 2: Orbital Vascular Malformations: Current Concepts
Chapter 3: Surgical Management of Thyroid Eye Disease: Recent Updates
Chapter 4: Dacryology: Present and the Future
Chapter 5: Principles for Management of Orbital Trauma
Chapter 6: Periocular Rejuvenation: A Brief Overview
Chapter 7: Emerging Trends in Socket Reconstruction
Chapter 8: Targeted and Immune Therapy for Periocular and Orbital Malignancies.

Summary: This book thoroughly reviews the diagnosis and treatment of injuries of the orbital walls and apex, including orbital floor, medial orbital wall, naso-orbito-ethmoid, orbitozygomatic, maxillary, and frontobasilar fractures. For each form of injury, signs and symptoms are identified and clear guidance is provided on the interpretation of clinical and radiological findings and on current surgical treatment methods. In addition, the role of orbital imaging techniques, including CT and MRI, in depicting anatomic relations is explained with the aid of a wealth of radiological images and photograph.

Contents:
Orbital infection: Bacterial Orbital Cellulitis
Fungal Orbital Cellulitis
Mycobacterial Orbital Cellulitis
Viral Orbital Cellulitis
Parasitic Orbital Cellulitis. Idiopathic Orbital
Inflammation and IgG4 variant
Sarcoidosis
Wegener?s Granulomatosis
Churg-Strauss Syndrome
Sjogren Syndrome
Langerhans? cell histiocytosis
Adult xanthogranulomatous Disorders
Kimura Disease
Inflammation associated with intraocular and orbital tumors
Graves? Eye Disease
Orbital lymphoproliferative disorder. .

Summary: Orbital Tumors, 2nd edition discusses advances in orbital disease and their treatment, offering readers an up-to-date, single volume reference for orbital tumors. Divided into two parts, this book covers everything from advances in oncogenesis and its relationship to orbital tumors, to medical genetics and the role of imaging in diagnosis of orbital tumors. Additionally, new information on incidence and behavior of tumors resulting from environmental and social trends is included. Written and edited by leaders in the fields of ophthalmology and oncology, Orbital Tumors, 2nd edition builds upon the first edition, proving to be a useful reference for orbital specialists and of significant interest to everyone dealing with orbital pathology from a clinical and scientific point of view.

Summary: This book on "Orchid Biology: Recent Trends & Challenges" reviews the latest strategies for the preservation and conservation of orchid diversity and orchid germplasm. It is an outcome of the Proceedings of the International Symposium on "Biodiversity of Medicinal Plants & Orchids: Emerging Trends and Challenges" held on 9-11 February 2018 at Acharya Nagarjuna University, India. In addition, eminent orchid experts from around the globe were invited to contribute to this book. All chapters were peer-reviewed by international experts. The Orchidaceae are one of the largest families of flowering plants, comprising over 700 genera and 22,500 species and contributing roughly 40 percent of monocotyledons. They also represent the second-largest flowering plant family in India, with 1,141 species in 166 genera, and contribute roughly 10% of Indian flora. Orchids comprise a unique group of plants and their flowers are among the most enchanting and exquisite creations of nature. Phylogenetically and taxonomically, the Orchidaceae are considered to be a highly evolved family among angiosperms. They show incredible diversity in terms of the shape, size and colour of their flowers, and are of great commercial importance in floriculture markets around the globe. Millions of cut flowers of Cymbidium, Dendrobium, Cattleya, Paphiopedilum, Phalaenopsis, Vanda etc., besides potted orchid plants, are sold in Western Countries and thus, the orchid cut flower industry has now become a multimillion-dollar business in Europe, the USA and South East Asia. Besides their ornamental value, orchids hold tremendous pharmaceutical potential. Root tubers of Habenaria edgeworthii form an important component of the 'Astavarga' group of drugs in Ayurvedic medicine. It is an established fact that tubers of some terrestrial orchids have been used to treat diarrhoea, dysentery, intestinal disorders, cough, cold and tuberculosis. Some orchids, particularly those belonging to the genera Aerides, Arachnis, Cattleya, Cymbidium, Dendrobium, Epidendrum, Oncidium, Paphiopedilum, Phalaenopsis, Renanthera, Vanda etc. have been extensively used to produce internationally acclaimed hybrids. Yet paradoxically, Indian orchids are victims of their own beauty and popularity. As a result, their natural populations have been declining rapidly because of unbridled commercial exploitation in India and abroad. In fact, some orchids are now at the verge of extinction, e.g. Renanthera imschootiana, Diplomeris hirsuta, Paphiopedilum fairrieanum, Cypripedium elegans, Taeniophylum andamanicum etc. Given the global importance of orchids in terms of securing human health and wealth, this comprehensive compilation, prepared by international experts, is highly topical. Its content is divided into five main sections: (I) Cryopreservation & Biotechnology, (II) Orchid Biodiversity & Conservation, (III) Anatomy & Physiology, (IV) Pollination Biology and (V) Orchid Chemicals & Bioactive Compounds. All contributions were written by eminent orchid experts/professors from around the world, making the book a valuable reference guide for all researchers, teachers, orchid enthusiasts, orchid growers and students of biotechnology, botany, pharmaceutical sciences and ethnomedicine. It will be equally valuable for readers from the horticultural industry, especially the orchid industry, agricultural scientists and policymakers.

Contents:
[I]. Cryopreservation and biotechnology: Cryopreservation development of some endangered Thai orchid species / Kanchit Thammasiri
Status of orchid industry in India / Sadanand N. Hegde
Cryobiotechnological studies in Vanilla : the orchid of multi-industrial uses / María Teresa González-Arnao, Fabiola Hernández-Ramírez, Natalia Raquel Dolce, Martha P. Rascón-Díaz, Carlos A. Cruz-Cruz
In vitro propagation and germplasm conservation of wild orchids from South America / Natalia Raquel Dolce, Ricardo Daniel Medina, Graciela Terada, María Teresa González-Arnao, Eduardo Alberto Flachsland
Postharvest technology of cut flowers of orchids / Mantana Buanong, Apiradee Uthairatanakij
Cryobiotechnology of Korean orchid biodiversity : a case study sing Cymbidium kanran / Elena Popova, Haeng-Hoon Kim. [II]. Orchid biodiversity and conservation: Species diversity and distribution of orchids in Rudraprayag District, Uttarakhand, India / V.P. Bhatt
Status of genetic diversity and its characterization in genus BUlbophyllum (Orchidaceae) from north-eastern India / Satyawada Rama Rao
Orchid diversity in Darjeeling Himalaya, India : present status and conservation / Mohammed Rahamtulla, Ashis Kumar Roy, S. M. Khasim
Orchid diversity in the eastern Ghats of Northern Andhra Pradesh, India / M. Venkaiah, J. Prakasa Rao, M. Tarakeswara Naidu, R. Prameela, P. Janaki Rao, S. B. Padal
History and scientific potential of the orchid collection of the Stock Greenhouse of the Main Botanical Garden RAS (Moscow, Russia) / Galina L. Kolomeitseva
Status of orchid diversity, conservation, and research and development in Arunachal Pradesh : an overview / Sadanand N. Hegde. [III]. Anatomy and physiology: Orchid mycorrhizal fungi : structure, function, and diversity / Kullaiyan Sathiyadash, Thangavelu Muthukumar, Velusamy Karthikeyan, Kuppu Rajendran
Orchid seed ultrastructure : ecological and taxonomic implications with reference to Epidendroideae (Orchidaceae) / J. Ramudu, S.M. Khasim, G. Ramesh
Structural adaptations of Bulbophyllum and Dendrobium (Orchidaceae) to the epiphytic habitat and their phylogenetic implications / G. Ramesh, J. Ramudu, S. M. Khasim, K. Thammasiri
Physiological response of Dendrobium cv Earsakul to plant growth promoters and growing systems / M. Raja Naik, K. Ajith Kumar, A. V. Santhoshkumar, P. K. Sudha Devi, M. Ramakrishna
Anatomical studies in some Indian Coelogyneae (Orchidaceae) / J. Ramudu, S.M. Khasim. [IV]. Pollination biology: Beauty of orchid flowers are not adequate to lure Indian biologists / Kamaladhasan N., Mohan Raj R., Soundararajan N., Indhar Saidanyan R., Saravanan S., Chandrasekaran S.
Evolution of organismal female wasp mimics in sexually deceptive orchid genus Chiloglottis (Orchidaceae) / Kamaladhasan N., Mohan Raj R., Krishnankutty N., Indhar Saidanyan R., Soundararajan N., Saravanan S. et al.
Pollination studies in the genus Habernaria Willd. (Orchidaceae) from western Ghats, India) / B.T. Dangat, R.V. Gurav. [V]. Orchid chemicals and bioactive compounds: Phytochemical analysis, antioxidant and anti-inflammatory activity of Eria tomentosa (Koen.) Hook. f. / Most. Tanzila Akter, Mohammed Kamrul Huda, Mohammed Mozammel Hoque, Minhajur Rahman
Medicinal orchids : production of bioactive compounds and biomass / So-Young Park, Thanh-Tam Ho, Kee-Yoeup Paek
Ethnomedicinal aspects of some orchids from Darjeeling Himalaya, India / Mohammed Rahamtulla, Udai C. Pradhan, Ashis Kumar Roy, Venkatesh Rampilla, S. M. Khasim
Evaluation pf phytoconstituents and antibacterial activity of Vanda tessellata using in vitro model / Karabi Biswas, Sankar Narayan Sinha
Screening of bioactive phytochemicals in some Indigenous epiphytic orchids of Bangladesh / M.M. hossain, S. Akter, S.B. Uddin
GC-MS analysis of organic extracts of Cymbidium aloifolium (L.) Sw. (Orchiadaceae) leaves from eastern Ghats of India / Venkatesh Rampilla, S.M. Khasim
Anticancer property in Acampe praemorsa and Aerides odorata (Orchidaceae), an in vitro approach / K. Jhansi, S.M. Khasim
Phytochemical screening and evaluation of antimicrobial potential of Dendrobium fimbriatum Hook / Sankar Narayan Sinha, Karabi Biswas.

Summary: This book provides information on genome complexity and evolution, transcriptome analysis, miRNome, simple sequence repeats, genome relationships, molecular cytogenetics, polyploidy induction and application, flower and embryo development. Orchids account for a great part of the worldwide floriculture trade both as cut flowers and as potted plants and are assessed to comprise around 10% of global fresh cut flower trade. A better understanding of the basic botanical characteristics, flower regulation, molecular cytogenetics, karyotypes and DNA content of important orchids will aid in the efficient development of new cultivars. The book also describes the composition, expression and function of various microRNAs and simple sequence repeats. Information on their involvement in all aspects of plant growth and development will aid functional genomics studies.

Contents:
Chapter 1. The Global Orchid Market
Chapter 2. The Breeding of Phalaenopsis Hybrids
Chapter 3. The Tiny Twig Epiphyte Erycina Pusilla
Chapter 4. Phalaenopsis Genome and Transcriptome Exploitation and its Application for Breeding
Chapter 5. Chromosome Analysis of Phalaenopsis Yellow Cultivars
Chapter 6. Regulation of Flowering in Orchids
Chapter 7. The Roles of MADS-box Genes During Orchid Floral Development
Chapter 8. Genomics, Transcriptomics and miRNA Family Resources for Phalaenopsis Aphrodite and the Orchid Family
Chapter 9. Genes and Noncoding RNAs Involved in Flower Development in Orchis Italica
Chapter 10. Phylogeny, Polymorphism, and SSR Markers of Phalaenopsis.

Summary: A presentation of 491 popular orchid species with 13 varieties and 3 natural hybrids in 51 genera with names beginning with A to E carefully detailed with beautiful photographs and concise descriptions of the plants, their distribution and habitats by a well-known author and photographer. Each genus is assigned a separate chapter. Coverage of the most commonly cultivated Asian species including their varieties and cultivars (e.g. in Bulbophyllum 82 species; Coelogyne 37 species; Dendrobium 210 species) is exhaustive. The orchids are photographed from their best perspective as individual blooms or entire inflorescences. Many species are also shown growing in their natural habitat. Representative hybrids are included to illustrate how some species have contributed to show-worthiness of various genera, their adaptation to a wider climate range, and easy cultivation. This book is a pleasure to view; simultaneously, an easy reference for the identification of orchid species and it provides a guide on how best to grow them. Nowhere else will one find so many popular species beautifully illustrated in a single volume. Volume 1 is the first of a 3 Volume series that will showcase over 900 species plus varieties in 117 genera. A must for everyone fascinated by orchids or simply with a love for nature.

Contents:
Chapter 1: Introduction
Chapter 2: AcampeLindl
Chapter 3: AcanthephippiumBl
Chapter 4: AcriopsisReinw. Ex Bl
Chapter 5: AdenoncosBl
Chapter 6: AeridesLour
Chapter 7: Aeridostachya(Hook.f.) Brieger
Chapter 8: AgrostophyllumBl
Chapter 9: AmesiellaSchltr. ex Garay
Chapter 10: AniaBl
Chapter 11: AnoectochilusBl
Chapter 12: AnthogoniumLindl
Chapter 13: ApostasiaBl
Chapter 14: AppendiculaBl
Chapter 15: ArachnisBl
Chapter 16: ArundinaBl
Chapter 17: AscidieriaSeidenf
Chapter 18: AscocentrumSchltr
Chapter 19: BrachypezaGaray
Chapter 20: BromheadiaLindl
Chapter 21: ByrobiumLindl
Chapter 22: BulbophyllumThouars
Chapter 23: CalantheR. Br
Chapter 24: CallostylisBl
Chapter 25: CephalantheraRich
Chapter 26: CeratostylisBl
Chapter 27: CheirostylisBl
Chapter 28: Chelonistele(Bl.) Pfitz
Chapter 29: ChiloschistaLindl
Chapter 30: CleisocentronBruhl
Chapter 31: CleisostomaBl
Chapter 32: CoelogyneLindl
Chapter 33: CorymborkisThouars
Chapter 34: CrepidiumBl
Chapter 35: CryptochilusWall
Chapter 36: CryptostylisR. Br
Chapter 37: CylindrolobusBl
Chapter 38: CymbidiumSw
Chapter 39: CypripediumL
Chapter 40: DactylorhizaNeck ex Nevski
Chapter 41: DendrobiumSw
Chapter 42: DendrochilumBl
Chapter 43: DendroliriumBl
Chapter 44: DieniaLindl
Chapter 45: DimorphorchisRolfe
Chapter 46: DiploploraJ. D. Hooker
Chapter 47: DipodiumR Br
Chapter 48: DossiniaE. Morren
Chapter 49: DyakiaChristen
Chapter 50: EpigeniumGagn
Chapter 51: EriaLindl
Chapter 52: EulophiaR. Br. ex Lindl.

Summary: Did you know that Vanilla was formerly served as aphrodisiac by Cassanova and Madam Pompadour, and Elizabeth I loved its flavor? This is the first book that provides a complete worldwide coverage of orchids being employed as aphrodisiacs, medicine or charms and food. Opening with an in-depth historical account of orchids (orchis Greek testicle), the author describes how the Theory of Signatures influenced ancient herbalists to regard terrestrial orchid tubers as aphrodisiacs. Doctors and apothecaries promoted it during the Renaissance. Usage of orchids in Traditional Chinese Medicine, Indian Ayurvedic Medicine; by Tibetan yogins and Amchi healers for longevity pills, tonics and aphrodisiacs; by Africans to prepare 'health promoting' chikanda or as survival food when lost in the Australian bush are some highlights of the book. Early settlers in America and the East Indies often relied on native remedies and employment of orchids for such needs is described. Also covered are the search for medicinal compounds by scientists, attempts to prove the orchid's efficacy by experiment and the worry of conservationists.

Contents:
Chapter 1: INTRODUCTION: Orchids as Medicine: A Historical Overview
Chapter 2: An Ancient Fantasy
Salep as Aphrodisiac
Chapter 3: Foremost Among Medicinal Orchids
Chapter 4: Dwelling on Rocks (Shihu)
Chapter 5: METAMORPHOSIS: Modern medicine finds new uses for an ancient herb
Chapter 6: Spiritual Tibetan Medicine; popular wangle
Chapter 7: The Story of Vanilla
Chapter 8: Modern Treasure Hunters
Chapter 9: Medicinal Orchids of Central America
Chapter 10: Medicinal Orchids of South America
Chapter 11: Usage of Medicinal Orchids
Chapter 12: INDIA: Van Rheede, Caius, and others
Chapter 13: Medicinal Orchids of Nepal and Bhutan
Chapter 14: Medicinal Orchids of Thailand and Myanmar
Chapter 15: Medicinal Orchids in the Malay Archipelago
Chapter 16: Australian Orchids as Food and Medicine
Chapter 17: Medicinal Orchid Usage in Rural Africa
Chapter 18: The Challenge: Orchid Conservation.

Summary: "In Ordinary Deaths, Dr. Samuel LeBaron reminds us of our need for human connection when faced with death and loss. Based on more than thirty years of working with children and adults dying from cancer, LeBaron's memoir contains stories of longing, confusion, love, and humility--often woven together. Sharing recollections from his childhood in rural Alberta and experiences from his career, LeBaron reveals a life of vital connection and intimacy with others. His employment at a morgue during medical school, his early years as a clinical psychologist, and later careers in primary care and hospice in California, all translate into compassion and a deep understanding of death. Writing as he faces his own terminal illness--stage IV lung cancer--LeBaron hopes to help readers find solace and confidence."-- Provided by publisher.

Summary: "In Ordinary light, Pulitzer Prize-winning poet Tracy K. Smith explores her coming-of-age and the meaning of home against a complex backdrop of race, faith, and the unbreakable bond between a mother and daughter."--Page 4 of cover.

Contents:
Prologue: The miracle
My book house
Wild kingdom
Spirits and demons
Kin
Leroy
A home in the world
MGM
Little feats of daring
Total adaventure
Book a big band
A necessary rite
Humor
Uninvisible
The night stalker
Hot and fast
Shame
Mother
Epistolary
Positive
Kathleen
Something better
The woman at the well
A strange thing to do
I, too
Testimony
Another dialect of the soul
Something powerful at her side
A strange atfer
Abide
Clearances
Epilogue: Dear God
Acknowledgments.

Summary: A singular achievement, Ordinary Notes explores profound questions about loss and the shapes of Black life that emerge in the wake. In a series of 248 notes that gather meaning as we read them, Christina Sharpe skillfully weaves artifacts from the past—public ones alongside others that are poignantly personal—with present realities and possible futures, intricately constructing an immersive portrait of everyday Black existence. The themes and tones that echo through these pages—sometimes about language, beauty, memory; sometimes about history, art, photography, and literature—always attend, with exquisite care, to the ordinary-extraordinary dimensions of Black life. At the heart of Ordinary Notes is the indelible presence of the author’s mother, Ida Wright Sharpe. “I learned to see in my mother’s house,” writes Sharpe. “I learned how not to see in my mother’s house . . . My mother gifted me a love of beauty, a love of words.” Using these gifts and other ways of seeing, Sharpe steadily summons a chorus of voices and experiences to the page. She practices an aesthetic of "beauty as a method,” collects entries from a community of thinkers toward a “Dictionary of Untranslatable Blackness,” and rigorously examines sites of memory and memorial. And in the process, she forges a brilliant new literary form, as multivalent as the ways of Black being it traces. -- Provided by publisher.

Summary: "Discovered in 1998, the orexin system lies at the core of the sleep and wake state regulation inside our brain. This book summarizes recent research, ideas and perspectives from some of the most influential researchers in the fields of hypocretin/orexin and sleep. For example, it explains the intricate role of the orexin system in the different sleep phases and in the pathways that are related to memory and cognition. It also provides an overview of diseases which are caused by, or associated with, a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, or Alzheimer's disease"-- Provided by publisher.

Contents:
Twenty-three years of hypocretins : the "Rosetta stone" of sleep/arousal circuits / de Lecea, L.
Interaction between orexin neurons and monoaminergic systems / Sakurai, T.; Saito, Y.C.; Yanagisawa, M.
Hypocretin/orexin receptor pharmacology and sleep phases / Sun, Y.; Tisdale, R.K.; Kilduff, T.S.
Sleep, Orexin and Cognition / Toor, B.; Ray, L.B.; Pozzobon, A.; Fogel, S.M.
Subsecond ensemble dynamics of orexin neurons link sensation and action / Burdakov, D.
Heterogeneity of hypocretin/orexin neurons / Sagi, D.; de Lecea, L.; Appelbaum, L.
Sleep and metabolism: implication of lateral hypothalamic neurons / Oesch, L.T.; Adamantidis, A.R.
Cellular signaling mechanisms of hypocretin/orexin / Kukkonen, J.P.; Turunen, P.M.
Sleep problems in narcolepsy and the role of hypocretin/orexin deficiency / Mignot, E.; Zeitzer, J.M.; Pizza, F.; Plazzi, G.
The insomnia-addiction positive feedback loop : Role of the orexin system / Fragale, J.; James, M.; Avila, J.; Spaeth, A.M.; Aurora, R.N.; Langleben, D.; Aston-Jones, G.
Causes and consequences of chronic sleep deficiency and the role of orexin / Mullington, J.M.; Cunningham, T.J.; Haack, M.; Yang, H.
Hypocretin/orexin, sleep and Alzheimer's disease / Dauvilliers, Y.

Summary: This book presents a view of the current environment of organ donation and transplantation after cardiac death in China, including legal and ethical aspects of cardiac death, assessment and management of potential organ donor, quality evaluation and machine perfusion of organ, as well as immunology, imaging and pathology related to transplantation from cardiac death donors. Since 2015, voluntary donation has been announced as the only legitimate venue for organ transplant in China. As cardiac death is adopted in China, the donation mode is different from those in other countries where brain death is adopted. It offers transplant surgeons and physicians valuable information on optimal practice proposal for organ donation after cardiac death in China.

Contents:
1 Legal, moral, and ethical issues related to cardiac death donation
2 Current situation of organ donation after cardiac death in china
3 Cardiac death donor evaluation and management
4 Organ procurement, quality evaluation and perfusion in cardiac death donation
5 Liver transplantation from cardiac Death Donors
6 Kidney transplantation from cardiac death donors
7 Lung transplantation from cardiac death donors
8 Pancreas and Islet Transplantation from Cardiac Death Donors
9 Multiple organ transplantation from cardiac death donors
10 Immunosuppressive strategies in transplantation using cardiac death donors
11 Ischemia and reperfusion injury in organ transplantation from cardiac death donors
12 Imaging related to transplantation from cardiac death donors
13 Pathological evaluation of DCD donor organs
14 Further Development of Organ Transplantation form Cardiac Death Donors in China.

Summary: "This book provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, in relation to the advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate deep scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watch outs, limitations, and 'bookend' boundaries involved in the stages of testing and development. With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets"-- Provided by publisher.

Contents:
Section I: In-vitro and Ex-vivo Methods
Estimating Clinically Relevant Measures of Inhaled Pharmaceutical Aerosol Performance with Advanced In Vitro and In Silico Methods / Conor A. Ruzycki, Warren H. Finlay, and Andrew R. Martin
In Vitro Assessment of Drug Release, Dissolution, and Absorption in the Lung / Rajan S. Bhattarai, Virender Kumar, Ajit S. Narang, and Ram I Mahato
Lung-on-a-Chip and other Organoid Models / Muhammad H. Malik, Shalaleh Masoumi, Xue Zhou, and Xinli Liu
Interaction between Inhalable Nanomedicines and Pulmonary Surfactant / Chuanbin Wu
Section I: Particle Design Understanding
Particle engineering for pulmonary drug delivery / Vikram Karde and Jerry Y.Y. Heng
Particle Architectonics for Pulmonary Drug Delivery / Kohsaku Kawakami
Engineered Particles for Aerosolisation and Lung Deposition / Rachel Yoon Kyung Chang and Hak Kim Chan
Section IV: Novel Technologies
Recent advances in inhalable nanomedicine for lung cancer therapy / Hadeer M. Abdelaziz, Mohamed Teleb, Sherine N. Khattab, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed O. Elzoghby
Thin-Film Freeze-Drying Process for Versatile Particles for Inhalation Drug Delivery / Chaeho Moon, Sawittree Sahakijpijarn, and Robert O. Williams III
Nanoparticles as specific drug carriers to the lungs / Thaís Larissa do Amaral Montanheiro, Karla Faquine Rodrigues, Renata Guimarães Ribas, Vanessa Modelski Schatkoski, Raissa Monteiro Pereira, and Gilmar Patrocínio Thim
Section IV: Advancing Established Technologies
Surface modification of micronized drug particles for aerosolization / Tania Bajaj, Vishav Prabhjot Kaur, Urvashi Anwekar, Deepak Chitkara, Charan Singh
Spray Dried Particles for Inhalation / Raj Kumar, Neha Kumari, and David Oupicky
Inhalation Aerosol Phospholipid Particles for Targeted Lung Delivery / Basanth Babu Eedara, David Encinas-Basurto, Don Hayes Jr, and Heidi M. Mansour
Nebulizers / Ariel Berlinski
Protein and Peptide Delivery to the Lung via Inhalation / Xin, Wang, Kumar, Narang and Mahato
Exosomes Based Drug Delivery for Lung Cancer Treatment / Rajagopal and Munshi

Summary: The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function. In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.

Contents:
Brain Central Neural System
Vison system, retina, cornea
Olfactory system
Craniomaxillofacial bone engineering
Ear, Nose and Throat
Dental, tooth
Thymus, Lymphoid
Oesophagus, Trachea
Lung
Gastro Intestinal Tract (Organoids)
Kidney
Bladder/Urethra
Liver (Biomaterial, Cells)
Endocrine Organs (Pancreas)
Salivary grand
Breast Tissue / Fat Tissue
Ovary
Penis
Great Vessels
Cell sheets for cardiac tissue engineering
Heart valve Bioengineering
Ligament
Meniskus als muskuloskelettaler Abschnitt
Tendons
Skeletal system and Muscle.

Summary: "This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future."--Publisher's description.

Contents:
Organelle communication at membrane contact sites (MCS): from curiosity to center stage in cell biology and biomedical research / Thomas Simmen, Mitsuo Tagaya
Over six decades of discovery and characterization of the architecture at mitochondria-associated membranes (MAMS) / Maria Sol Herrera-Cruz, Thomas Simmen
Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane / Mitsuo Tagaya, Kohei Arasaki
Endoplasmic reticulum-mitochondria communication through Ca2+ signaling: the importance of mitochondria-associated membranes (MAMS) / Saverio Marchi, Mart Bittremieux, Sonia Missiroli, Claudia Morganti, Simone Patergnani [and others]
Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites / Kentaro Hanada
Endoplasmic reticulum-plasma membrane crosstalk mediated by the extended synaptotagmins / Yasunori Saheki
Endoplasmic reticulum-plasma membrane contacts regulate cellular excitability / Eamonn J. Dickson
The lipid droplet and the endoplasmic reticulum / Yuki Ohsaki, Kamil Sołtysik, Toyoshi Fujimoto
Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis / Yasushi Tamura, Toshiya Endo
Discovery and roles of ER-endolysosomal contact sites in disease / William Mike Henne
Alzheimer disease / Estela Area-Gomez, Eric A. Schon
Mitochondrial-associated membranes in Parkinson's disease / Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori, Yuzuru Imai
Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes / Jennifer Rieusset
Mitochondrial-endoplasmic reticulum contact sites mediate innate immune responses / Takuma Misawa, Michihiro Takahama, Tatsuya Saitoh
Hepatitis C virus replication / Tetsuro Suzuki
Hijacking of membrane contact sites by intracellular bacterial pathogens / Isabelle Derré
Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer / Martijn Kerkhofs, Carlotta Giorgi, Saverio Marchi, Bruno Seitaj, Jan B. Parys [and others].

Summary: This book addresses, reviews and evaluates key themes in organic aquaculture and is set out to show how these relate to the challenges and bottlenecks for a responsible organic aquaculture production in Europe. The key themes reflect the main challenges facing the organic aquaculture industry: guarantee and certification system, nutrition, reproduction, production system design and animal welfare. In addition, it assesses the impact of new and future potential development of new knowledge to update and modify the criteria and standards for organic aquaculture. Organic aquaculture is an alternative production approach driven by the growing interest in sustainable utilization of resources. It is rightly viewed as an important contributor to the economy and to the well-being and health of communities. This work will contribute to the scientific knowledge that needs to strengthen effective organic aquaculture. The collation of information on research and data will be of applied value to researchers, university students, end users and policy authorities in the EU and worldwide.

Contents:
Intro; Preface; Acknowledgements; Contents; About the Editors and Contributors; List of Figures; List of Tables;
Chapter 1: Organic Aquaculture: Principles, Standards and Certification; Introduction; Organic Principles Applied to Aquaculture; Principle of Health; Principle of Ecology; Principle of Fairness; Principle of Care; Organic Aquaculture Standards and Regulations Around the World; Scope and Content of Organic Aquaculture Standards; Elements of Organic Aquaculture Standards; System Design and Location; Conversion to Organic Aquaculture; Sources of Stock, Breeds and Breeding Algae and Microalgae Production Production of Molluscs; Feeding and Nutrition of Aquaculture Animals; Health and Welfare; Harvest, Transportation and Slaughter; Processing and Labelling; Guarantee Systems, Certifications, Market Access and Labelling; Certification; Other Guarantee Systems; Labelling; Import Requirements; Hints on the Control and Certification System in Europe; References;
Chapter 2: EU Regulation on Organic Aquaculture; Introduction; Organic Aquaculture in Regulation (EC) No 834/2007; Organic Aquaculture in Regulation (EC) No 889/2008; Seaweed Production Animal Production: General Rules Origin of Aquaculture Animal; Aquaculture Husbandry Practices; Breeding; Feed for Fish, Crustacean and Echinoderm; Specific Rules for Mollusc; Disease Prevention and Veterinary Treatments; The Organic Control System; Steps and Obligation for the Organic Operators; The New Organic Control System; Labelling in the European Union; The Import Regime; System 1: Recognised Equivalent Third Countries; System 2: Control Bodies/Authorities Recognised for the Purpose of Equivalence; System 3: Control Bodies/Authorities Recognised for the Purpose of Compliance Impact of Aquaculture Breeding Programs Aquaculture Breeding Program Design; Inbreeding Management; Estimation of Breeding Values; Important Selection Traits for Organic Aquaculture; Feed Efficiency; Disease Resistance; Selection for Skewed Sex Ratio Stocks; Genotype by Environment Interaction (GxE) in Selective Breeding Programs; Novel Omics Technologies in Organic Aquaculture; Genomics; Transcriptomics; Proteomics; Metabolomics; Conclusion; References;
Chapter 5: Early Life Stages and Weaning; Development, Feeding, and Nutritional Requirements of Marine and Freshwater Fish Larvae System 4: Import Authorisations The Organic Import System in the New Organic Regulation; References;
Chapter 3: Organic Aquaculture: Economic, Market and Consumer Aspects; Background; Organic Aquaculture Production; The Economics of Organic Aquaculture; Consumer Awareness and Product Knowledge; Labels and Label Knowledge; Consumer Attitudes; Consumer Preferences and Willingness to Pay for Organic Seafood in Europe; Concluding Remarks; References;
Chapter 4: Genomics Era on Breeding Aquaculture Stocks; Aquaculture Selective Breeding Background; Introduction

Summary: Organic Chemistry for Pharmacy is a textbook written specifically for the students taking the required Organic/Medical Pharmacy course. Using a building- block approach, the book delivers a basic, yet thorough discussion of the mode of action, therapeutic applications, and limitations of various pharmaceutical agents.

Contents:
Chemical structure and bonding / Adam Renslo, Dmitry Koltun
Non-covalent interactions / Adam Renslo
Stereochemistry / Adam Renslo
Conformations of small molecules / Adam Renslo
Acid-base chemistry / Susan M. Miller
Addition, substitution, and elimination reactions / Jie Jack Li, Adam Renslo
Reactions of carbonyl species / Adam Renslo
Radical chemistry / John Flygare, Adam Renslo.

Summary: This volume provides an overview of the fundamental concepts and recent advancements in organic farming, a form of agriculture that is increasing rapidly in popularity. Readers will discover information on the history of organic farming, environmental friendly practices and challenges, and innovations in the field. The chapter authors analyze pertinent aspects of this integrated farming system including strategies to improve seed quality, methods to improve soil fertility, and the advantages of using organic fertilizers. Particular attention is also given to weed management practices, bioenergy production and insights into the ways organic farming can adapt to global climate change and build sustainable food systems for future generations. Scientists, decision-makers, professors, and farmers who wish to work towards making agricultural systems more sustainable will find this book appealing.

Contents:
Intro; Preface; Contents; Organic Farming in Protecting Water Quality; Introduction; What Are the Different Ways by Which Water Quality Deteriorates?; Organic Farming; Aims and Definitions of Organic Farming; Organic Farming: Environmental Benefits; Nutrient Leaching and Runoff; How Organic Farming Controls Nutrient Leaching and Runoff; Positive Management Practices to Minimize Nutrient Leaching and Runoff; Soil Erosion; Positive Practices That Minimize Erosion; Pathogens; Positive Practices; Pesticides; Positive Practices; Heavy Metals; Conclusion; References Current Status and Soil Biology Impacts of Organic Conservation Tillage in the US Great PlainsIntroduction; Organic Continuous-NT Systems; Conservation-Tillage Impacts on the Soil Food Web; Effect of Conservation Tillage on the Soil Microbial Community; Impact of Tillage on Nematodes; Impact of Tillage on Soil Meso- and Macrofauna; Suggestions for Future Research; References; Use of Biochar in Organic Farming; Chapter Overview; Introduction: Biochar History and Use in Agricultural Systems; Biochar Generation and Properties; Biochar Generation; Physical and Structural Properties of Biochar Macromolecular Properties of BiocharInfluence of Biochar on Soil Properties; Soil Physical Properties; Soil Biochemical Properties; Soil Microorganisms; Influence of Biochar on Crop Productivity in Organic Agriculture; Biochar in Organic Agriculture: The San Juan Experience; Background and Biochar Generation; Study Design and Results; Linking Sustainable Agroforestry to Organic Farming; References; Pest and Disease Control Strategies in Organic Fruit Production; Soil Management Practices to Reduce Pest Incidence; Field Management Practices to Reduce Pest Incidence Physical Methods to Control Flying PestsBotanicals in Pest and Disease Control; Microbial Bioagents in Pest Control; Natural Enemies for Pest Management; Ecological Engineering Approaches; Biodiversity with Flowering Plants; Intercrops to Check Pest Incidence; Trap Cropping; Physical Methods to Control Postharvest Pests and Diseases; Plant Products to Control Postharvest Pests and Diseases in Fruits; Conclusion; References; Pesticides: Classification, Detection, and Degradation; Introduction; Detection of Pesticides; Chromatographic Techniques; Supercritical Fluid Extraction Pressurized Liquid ExtractionGel Permeation Chromatography; Analysis of Pesticides; Conclusion; References; Organic Animal Husbandry; Introduction; Objectives of Organic Animal Husbandry; Role of Livestock in Organic Agriculture; Animal Welfare in Organic Agriculture; Role of Organic Agriculture on Animal Health; Reduce Incidence of Diseases; Promotes Health of Animal; Reduces Pain and Stress Through Standard Animal Welfare; Organic Livestock Production Standards; The European Union Organic (EU Organic) Standard for Livestock Production

Summary: "Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug deliveryHighlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug deliveryAssesses how molecular organic frameworks lead to more effective drug delivery systems"-- Provided by publisher.

Contents:
1. Metal-organic frameworkds as expanding hybrid carriers with diverse therapeutic applications
2. Natural and semisynthetic polymers in pharmaceutical nanotechnology
3. Current perspectives on drug release studies from polymeric nanoparticles
4. Polymeric nanofibers for controlled drug delivery applications
5. Polymeric hydrogels for contact lens-based ophthalmic drug delivery systems
6. Palm-based nanoemulsions for drug delivery systems
7. Strategies for the design and synthesis of pincer-based dendrimers: potential applications
8. Nanohydrogels: emerging trend for drug delivery
9. Lipid-based nanoparticles for dermal drug delivery
10. Lipid-based nanoparticles for cancer diagnosis and therapy
11. Lyotropic liquid crystal nanoparticles: a novel improved lipidic drug delivery system
12. Vesicular carriers as innovative nanodrug delivery formulations
13. Gemini surfactant-based systems for drug and gene delivery
14. Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology
15 Cyclodextrin-based nanoparticles
16. Cyclodextrin nanosponge-based systems in drug delivery and nanotherapeutics: current progress and future prospects.

Contents:
Organism Models: Choosing the Right Model
The Autistic Spectrum Disorders (ASD) : From the Clinics to the Molecular Analysis
Selecting the Right Species: Practical Information on Organism Models
Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution
In Vivo Imaging in Mice
Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders
Epigenetic Factors in Normal and Pathological Neuronal Development
Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts
Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders
Communication and Language in Animals
Social Relationships in Nonhuman Primates: Potential Models of Pervasive Disorders
Zebrafish Social Behaviour Testing in Developmental Brain Disorders
Maintaining Mice for Neurobehavioral Examination
Deficit in Social Relationships and Reduced Field of Interest in Mice
Modeling Autism Spectrum Disorders Motor Deficits in Mice
Neuro-Behavioral Testing of Mouse Models of Rett Syndrome
Mouse Models of Tuberous Sclerosis
Use of the Zebrafish Model to Understand Behavioral Disorders Associated with Altered Oxytocin System Development: Implications for Autism and Prader-Willi Syndrome
Epilogue: Perspectives and Caveats.

Contents:
Part I: IVF Unit Establishment and Organization
IVF Unit Location, Design, and Construction
Batch IVF Program in ART: Practical Considerations
Risk and Regulation: The Role of Regulation in Managing an IVF Unit
Part II: Total Quality Management
Risk and Disaster Management of the IVF Laboratory
Staff Management
Patient Management: A Nursing Perspective
Low Risk Laboratory Management
Cryobank Management
PGD/PGS Management
Data Management
Implementation of a Total Quality Management System
Optimization of Treatment Outcomes for Assisted Reproductive Technologies
Statistical Process Control Analysis to Assess Laboratory Variation as a Means of Quality Control in ART
Part III: IVF Units and Society
Ethics of IVF Treatment
Implementing and Managing Natural and Modified Natural Cycle IVF
Public and Low-Cost IVF Units
Private and Corporate IVF Units
Part IV: Advertising and Marketing IVF Units
Marketing of IVF Units and Agencies
Websites for IVF Units
IVF Units and Social Media.

Summary: Understanding and improving how organizations work and are managed is the object of management research and practice, and this topic is of longstanding interest in the academia and in society at large. More recently, the contribution that the study of the brain could make to, notably, our understanding of decisions, emotional reactions, and behaviors has led to the emergence of the field of "organizational neuroscience". Within the field of management, organizational neuroscience seeks to explore linkages between neuroscience research, theories, and methods and management research. Its primary goal is to incorporate findings on the cognitive processes underlying the thoughts, behaviors and attitudes of organizational actors in order to better inform management theories, and to assist in understanding, predicting and improving these behaviors in the workplace. As a result, we have seen in the last decade a flurry of research projects and publications in organizational neuroscience, as well as novel or rejuvenated innovations around neuromarketing, neuroleadership, and cognitive enhancement in the work place, to name a few. However, research and practical applications in organizational neuroscience pose profound ethical challenges about, for example, organizational responsibility in the responsible use of scientific innovation. Drawing on recent debates in the field, and in response to upcoming ethical challenges of organization neuroscience, this book introduces "organizational neuroethics" as an emerging interdisciplinary field that addresses the ethics of organizational neuroscience research and applications, as well as the neuroscience of organizational ethics. The first part focuses on the ethics of organizational neuroscience and several chapters tackle the ethics of neuromarketing or neuroleadership and discuss the ethical issues associated with neuroenhancement practice in the workplace. The second part of the book addresses cutting-edge topics in the neuroscience of organizational ethics. Written by international experts in the fields of management, neuroscience, ethics, and social science, this book will be of prime interest to practitioners, researchers and students in the various fields concerned with improving management research and practices, as well as organizational ethics.

Contents:
Intro; Acknowledgements; Contents; 1: Introduction; References; Part I: The Ethics of Organizational Neuroscience; 2:
Section Introduction: The Ethics of Organizational Neuroscience; 3: On the Ethics of Neuromarketing and Sensory Marketing; 3.1 Introduction; 3.2 What Is There to Worry About?; 3.2.1 Interim Summary; 3.3 Some Problematic Cases; 3.3.1 Some Outstanding Ethical Issues; 3.3.2 Multiple Uses for Commercial Neuromarketing; 3.3.3 Dealing with ``the File Drawer Problem;́́ 3.3.4 Ethical Concerns with the Use of Sensory Marketing 3.3.5 Sensory Marketing of Foods in an Obesogenic Environment3.4 Conclusion; References; 4: Neuroethics in Leadership Research and Practice; 4.1 Introduction; 4.2 The Neuroscience of Leadership; 4.3 Ethical Issues in Neuroleadership Research; 4.3.1 Methodological Concerns; 4.3.2 Types of Ethical Dilemmas; 4.4 Ethical Issues in Neuroleadership Practice; 4.4.1 Pre-assessment: Potential Coercion; 4.4.2 Neuro-screening: Employee Selection and Placement; 4.4.3 Neurofeedback: Leadership Training; 4.5 Conclusion; References 5: `Murder They Said:́ A Content Analysis and Further Ethical Reflection on the Application of Neuroscience in Management5.1 Introduction; 5.2 Content Analysis; 5.3 Conclusion; References; 6: Consumer Neuroscience: Recent Theoretical and Methodological Developments for Research and Practice Using a Cube Model; 6.1 Introduction; 6.1.1 Understanding the Consumer; 6.1.2 Measuring Unconscious and Implicit Decision-Making Processes; 6.1.3 Consumer Neuroscience; 6.2 The Cube Model of Consumer Neuroscience; 6.2.1 Potential Benefits of Consumer Neuroscience; 6.2.2 Limitations of Consumer Neuroscience 6.2.3 Consumer Neuroscience and Ethical Issues6.3 Conclusion and Further Research; References; 7: Neuroenhancement at Work: Addressing the Ethical, Legal, and Social Implications; 7.1 Introduction; 7.2 Existing Neuroenhancers Relevant to the Workplace; 7.2.1 Pharmaceutical Enhancement; 7.2.1.1 Methylphenidate; 7.2.1.2 Amphetamine; 7.2.1.3 Modafinil; 7.2.2 Neurotechnological Enhancement; 7.2.2.1 Transcranial Direct-Current Stimulation; 7.2.2.2 Transcranial Magnetic Stimulation; 7.2.2.3 Electroencephalography (EEG)-Based Devices; 7.3 Regulatory Options for Neuroenhancement; 7.4 Conclusion

Summary: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.

Contents:
Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh
How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development
Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development
In Vitro Models of the Blood-Brain Barrier
Neural In Vitro Models for Studying Substances Acting on the Central Nervous System
Engineered Heart Muscle Models in Phenotypic Drug Screens
Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection
Skin Disease Models In Vitro and Inflammatory Mechanisms: Predictability for Drug Development
Immunocompetent Human Intestinal Models in Preclinical Drug Development
Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling
Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development
The CAM Assay as an Alternative In Vivo Model for Drug Testing.

Contents:
1. Organoids and mini-organs: introduction, history, and potential
2. Elements of organoid design
3. Intestinal organoids: mini-guts grown in the laboratory
4. Three-dimensional breast culture models: new culture models for analyzing breast development and function
5. Prostate organoids: directed differentation from embyronic stem cells
6. Kidney organoids
7. Spontaneous self-assembly of liver organoids from differentiated human cells: human liver organoids
8. Cerebral organoids: building brains from stem cells
9. From organoids to mini-organs: a case study in the kidney
10. Intestinal organoids: a model for biomedical and nutritional research
11. A three-dimensional neurosphere system using human stem cells for nanotoxicology studies
12. Organoids for modeling kidney disease
13. Intestinal organoids in studying host-bacterial interactions
14. Four challenges for organoid engineers
Index.

Summary: The book includes 19 selected contributions presented at the 21st Evolutionary Biology Meeting, which took place in Marseille in September 2017. The chapters are grouped into the following five categories: · Genome/Phenotype Evolution · Self/Nonself Evolution · Origin of Biodiversity · Origin of Life · Concepts The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research. The aim of these meetings is to promote the exchange of ideas to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is in invaluable source of information for scientists, teachers and advanced students.

Contents:
Intro; Preface; Acknowledgements; Contents; Genome/Phenotype Evolution; Pmela and Tyrp1b Contribute to Melanophore Variation in Mexican Cavefish; 1 Introduction; 2 Materials and Methods; 2.1 Melanophore Scoring; 2.2 Quantitative Trait Locus (QTL) Association Mapping; 2.3 Gene Ontology (GO) Term Analysis; 2.4 RNA-Seq, Qualitative, and QPCR Expression Analyses; 2.5 Whole-Mount In Situ Hybridization; 2.6 Functional Validation in Zebrafish with MO Knockdowns; 3 Results. 3 Mechanisms of Thermotolerance in S. cerevisiae4 Methods for Improving Stress Tolerance; 5 Acquisition of Thermotolerance in Yeast by Adaptive Evolution; 6 Comprehensive Analysis of the Thermotolerant Yeast Strain YK60-1; 7 Genomic Analysis to Identify the Key Mutations for Improved Thermotolerance; 8 Conclusions and Perspectives; References; The Domestication Syndrome in Phaseolus Crop Plants: A Review of Two Key Domestication Traits; 1 Introduction; 2 Domestication Areas of Phaseolus Beans; 3 Phenotypic Evaluations of Two Key Domestication Traits in Phaseolus Beans; 3.1 Pod Shattering. 3.1 Cavefish × Surface Fish Hybrid Individuals Demonstrate Diversity in Melanophore Numbers in Distinct Regions Spanning the Body3.2 QTL Analysis Revealed 19 Genomic Regions Associated with Complex Melanophore Variation; 3.3 Comparative Analyses Narrowed Melanophore QTL Positions to Critical Genomic Regions in Astyanax and Danio; 3.4 Tyrp1b and Pmela Are Two Candidate Genes Associated with Numerical Melanophore Diversity; 3.5 Tyrp1b and Pmela Demonstrate Distinct Melanophore-Specific Expression Patterns Between Cave and Surface Morphotypes. 3.6 Functional Analyses of Tyrp1b and Pmela Reveal Altered Melanophore Dispersion and Structure in Morphants4 Discussion; 4.1 Tyrp1b and Pmela Contribute to Melanophore Number Variation in Cavefish; 4.2 Analysis of Complex Pigmentation Informs the Genetic Basis for Regressive Evolution in Cavefish; 4.3 Astyanax mexicanus Enables Investigation of Degenerative Pigmentation Disorders; References; Adaptive Evolution of Yeast Under Heat Stress and Genetic Reconstruction to Generate Thermotolerant Yeast; 1 Introduction; 2 Heat Stress in S. cerevisiae. 4 Seed Size5 Molecular Genetics and Genetic Architecture of Pod Shattering; 6 Genetic Architecture of Seed Weight; 7 Conclusions; References; Tracing the Evolutionary Origin of the Gut-Brain Axis; 1 Introduction-The Holobiont Imperative; 2 Developmental Symbiosis and the Evolution of New Organs; 3 Thoughts About the Evolution of the Nervous System; 4 Of Neurological Disorders and Animals as Complex Systems: Why Bacteria Matter; 5 The Gut-Brain Axis; 6 The Hydra Holobiont-A Model Organism to Study the Microbiota-Gut-Brain Axis; 7 Hydra Neurons Shape the Microbiota.

Summary: This book summarizes the latest research on the origins of language, with a focus on the process of evolution and differentiation of language. It provides an update on the earlier successful book, "The Origins of Language" edited by Nobuo Masataka and published in 2008, with new content on emerging topics. Drawing on the empirical evidence in each respective chapter, the editor presents a coherent account of how language evolved, how music differentiated from language, and how humans finally became neurodivergent as a species. Chapters on nonhuman primate communication reveal that the evolution of language required the neural rewiring of circuits that controlled vocalization. Language contributed not only to the differentiation of our conceptual ability but also to the differentiation of psychic functions of concepts, emotion, and behavior. It is noteworthy that a rudimentary form of syntax (regularity of call sequences) has emerged in nonhuman primates. The following chapters explain how music differentiated from language, whereas the pre-linguistic system, or the "prosodic protolanguage," in nonhuman primates provided a precursor for both language and music. Readers will gain a new understanding of music as a rudimentary form of language that has been discarded in the course of evolution and its role in restoring the primordial synthesis in the human psyche. The discussion leads to an inspiring insight into autism and neurodiversity in humans. This thought-provoking and carefully presented book will appeal to a wide range of readers in linguistics, psychology, phonology, biology, anthropology and music. -- Provided by publisher.

Contents:
Empirical evidence for the claim that the vocal theory of language origins and the gestural theory of language origins are not incompatible with one anoter / Nobuo Masataka
Primate vocal anatomy and physiology : similarities and differences between humans and nonhuman primates / Takeshi Nishimura
Integrations of multiple abilities underlying the vocal evolutions in primates / Hiroki Koda
Conversation among primate species / Loïc Pougnault, Florence Levréro, Alban Lemasson
Language evolution from a perspective of Broca's area / Masumi Wakita
Social scaffolding of vocal and language development / Hirokazu Doi
Emergence of the distinction between "verbal" and "musical" in early childhood development / Aleksey Nikolsky
"Talking Jew's harp" and its relation to vowel harmony as a paradigm of formative influence of music on language / Aleksey Nikolsky
Were musicians as well as artists in the Ice Age caves likely with autism spectrum disorder? A neurodiversity hypothesis / Nobua Masataka.

Summary: This cutting-edge book is a quick reference guide to the evidence-based evaluation, diagnosis, and management of the broad spectrum of orofacial disorders. Each chapter is devoted to a particular disease or disorder and presents advances in understanding of the condition, the most recent evaluation and diagnostic strategies, and up-to-date treatment approaches. In addition, strategies for integration of care into routine dental practice are explained, and information provided on practice management concepts. The coverage encompasses the latest technological advances in the field, such as gene transfer techniques, new pharmaceuticals, innovations in craniofacial imaging, and intelligent digital records for orofacial disorders. Although the management of orofacial disorders is emerging as a distinct field of dentistry, many dentists and physicians are unfamiliar with recent advances in the care of patients with orofacial disorders, orofacial pain, and headache. This book, written by world class experts, is deliberately geared to the level of understanding of a clinician nonscientist. It will serve as an ideal evidence-based reference and source of specific clinical recommendations in daily practice.

Summary: This book provides up-to-date information on all aspects of orofacial pain biomarkers. It opens by presenting background information on clinical phenotypes and the neurobiological substrates underlying chronic orofacial pain and by explaining the potential role of biomarkers in the diagnosis, prognostic evaluation, and treatment of orofacial pain. The main section of the book examines the contribution of human and animal studies to the field of biomarkers for orofacial pain and discusses biomarkers for masticatory muscle pain, temporomandibular joint pain, neuropathic face pain, and autonomic nervous system involvement in trigeminal facial pain. The potential impacts of the immune system on orofacial pain biomarkers and candidate gene phenotypes with possible links to chronic orofacial pain conditions are also addressed, and differences and similarities between saliva and serum biomarkers for pain are explained as well. The final section covers research-related issues in assessment methods and statistical analyses used in evaluating biomarkers, identifies future challenges and suggests new directions in the field.

Contents:
Background: Chronic Orofacial Pain Conditions
Neurobiologic Mechanisms of Chronic Orofacial Pain
Biomarkers
Role for Diagnosis, Treatment and Prognosis of Orofacial Pain
Methodology: Saliva and Serum Biomarkers
The Search for Pain Biomarkers
Orofacial Pain Biomarkers: Contribution of Animal Studies
Masticatory Muscle Pain Biomarkers and Biochemical Fingerprint of Myofascial Trigger Points
Temporomandibular Joint Pain Biomarkers
Genetic Biomarkers and Temporomandibular Pain Disorders
Neurophysiologic and Neuropathologic Biomarkers in Neuropathic Face Pain
Biomarkers of Autonomic System Involvement in Trigeminal Face Pain
Immune System and the Modulation of Cytokines Biomarkers
New Perspectives: Future Studies, Limitation, Clinical Implication
Conclusion.

Summary: This easy-to-use book equips clinicians and health care professionals with all the information that they will require in order to identify and manage orofacial complications of cancer therapy. Readers will find precise information on the presenting symptoms and signs associated with local or systemic complications associated with individual drugs or modes of therapy in cancer care. Guidance is provided whenever possible on the initial examinations to be performed in each circumstance and the investigations that can deliver a definitive diagnosis. The effective management of cancer complications are explained with the help of up to date clinical practice guidelines for the management of complications secondary to cancer therapy. In addition, an introductory section outlines contemporary principles of cancer management based on precision oral oncology principles. The text is supported by numerous highly informative clinical photographs, tables and a bibliography.

Contents:
Management of Oral Cancer: Haematological Malignancies
Solid Tumours and Medical Oncology
Head and Neck Cancer
Cancer and Radiation Oncology Orofacial Complications in Cancer Therapy: Oral Mucositis
Oral Bacterial, Viral and Fungal Infections
Xerostomia and Other Salivary Gland Disorders
Soft Tissue and Hard Tissue Necrosis
Trismus and Temporomandibular Dysfunction
Cutaneous Manifestations
Fibrosis and Scarring
Dental and Oral Diseases
Drug-Specific Complications
Oral Assessment Tools
Graft Versus Host Disease (GVHD). Consequences of Orofacial Complications in Cancer Therapy: Dysphagia
Dysgeusia
Dysphonia
Altered Nutrition. Oral Oncology in Different Populations: Geriatric Cancer Population
Paediatric Cancer Population. Guidelines and Other Resources for Supportive Care Relevant to Oral Oncology: Role of Oral Oncologists in Supportive Care in Cancer
Guidelines for Orofacial Complications Management
Guidelines for Dental Management of the Cancer Patient
Interpretation of Investigations
Precision Oncology and Supportive Care in Cancer.

Summary: This book is a practical guide that will assist ENT doctors in interpreting swallowing videoendoscopies correctly and in choosing complementary instrumental examinations to consolidate or exclude their provisional diagnosis. In addition, it provides speech-language pathologists with valuable hints on how to treat patients with oropharyngeal dysphagia more efficiently. The book is constructed around videoendoscopic features. The relevance of these features to diagnosis and treatment is carefully described with the aid of numerous high-quality illustrations. Beyond this, the relationship of videoendoscopy to two further instrumental examinations – videofluorography and pharyngeal manometry– and to the three treatment paths of texture adaptation, rehabilitation, and surgery is explained. The use of pictograms in this context helps to elucidate the connections, creating in the readers mind "clusters of behaviors" of benefit in clinical practice. The book also includes a short summary on swallowing anatomy and physiology, a chapter on medications inducing dysphagia, key take-home messages, and suggestions for further reading.

Contents:
1 Videoendoscopy
2 Videofluoroscopy. -3 High-Resolution Manometry
4 Transnasal Esophagoscopy
5 Physiology and Anatomy of Swallowing in a Nutshell
6 Dos and Donts in Deglutology
7 Multidisciplinary Texture Management
8 Rehabilitation.-9 Surgical Management.

Summary: "This book is about the struggle to save the lives of children who, because of a roll of the genetic dice, are born with any one of more than several thousand rare genetic disorders. It recounts the now century long effort of small groups of physicians and scientists to take on some of these genetic diseases. In many cases just a few physician-scientists have made an immense contribution to blazing a path toward new therapies"-- Provided by publisher.

Summary: Focusing on clinical practice, this book explores the less common diseases affecting the airways, systematic disorders with lung involvement, interstitial lung diseases and many other orphan conditions of the lungs. It helps the reader to diagnose and manage these rare orphan diseases. Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease is a practical, informative book written by a team of international authors with much experience in rare pulmonary diseases. Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease provides synthesized and easily accessible information about the main orphan lung diseases, to aid clinicians in charge of patients with rare disease, or who consider the diagnosis of a rare disease in their patient.

Contents:
1. Orphan Lung Diseases: From definition to organisation of Care
2. The Challenge of clinical research in orphan lung diseases
3. Chronic bronchiolitis in adults
4. Diffuse bronchiectasis of genetic origin
5. Allergic bronchopulmonary mycosis
6. Orphan Tracheopathies
7. Amyloidosis and the respiratory tract
8. Churg-Strauss syndrome: A clinical and therapeutic approach
9. Granunomatosis with polyangiitis (Wegener?s granylomatosis)
10. Alveolar Hemorrhage
11. Pulmonary Involvement in Takayasu Arteritis and Behçet Disease
12. Pulmonary vascular manifestations of hereditary hemorrhagic
13. Hepatopulmonary syndrome
14. Non-Langerhans cell histiocytosis -including Erdheim-Chester disease- and the lung
15. Idiopathic eosinophilic pneumonia
16. Multiple cystic lung disease
17. Lymphangioleiomyomatosis
18. Pulmonary alveolar Proteinosis
19. Exogenous lipoid pneumonia
20. Pulmonary alveolar microlithiasis
21. Pulmonary Fibrosis and the many faces of UIP
22. The syndrome of combined pulmonary fibrosis and emphysema
23. Non-specific, Unclassifiable, and Rare Idiopathic Interstitial Pneumonia
24. Organizing Pneumonias
25. Interstitial lung disease in systemic sclerosis
26. Interstitial lung disease in connective tissue diseases other than systemic sclerosis
27. Interstitial Lung Disease in Undifferentiated Forms of Connective Tissue Disease
28. Langerhans cell Granulomatosis and smoking-related interstitial lung diseases
29. Rare causes and the spectrum of hypersensitivity penumonitis
30. Chronic beryllium disease and other insterstitial lung diseases of occupational origin
31. Lymphoproliferative lung disorders
32. Pulmonary manifestations of hematological malignancies
33. Pulmonary hypertension in orphan lung diseases
34. Orphan and rare drug-induced and iatrogenic respiratory disease
35. From cancer mimicking orphan lung disease to orphan thoracic oncology
36. Rare Diffuse lung diseases of genetic origin.

Summary: This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies ranging from tendinopathies through non-unions to articular degenerative processes as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

Contents:
I. Injectable OrthoBiologics: Formulations and Rationale 1. Bone marrow-derived cultured stromal cells and Bone Marrow Concentrate
2. Adipose-derived cultured stromal cells and Stromal Vascular Fraction from adipose tissue
3. Synovial-derived cultured stromal cells
4. Amniotic, Placenta, and Umbilical cord-derived cultured stromal cells
5. Allogeneic cells: pros and cons
6. Steroid hormones
7. Cytokines, chemokines, alpha-2-macroglobulin, growth factors
8. Platelet-rich plasma: leucocyte-rich, leukocyte-poor, autologous conditioned serum, autologous protein solution
9. Amniotic tissue extract, placenta tissue extract
10. Extracellular vesicles (exosomes)
II. Injectable OrthoBiolologics: evaluation methods and results based on pathology and anatomy
11. Rotator cuff tendinopathy: cell therapy
12. Rotator cuff tendinopathy: biologics
13. Tennis elbow: cell therapy
14. Tennis elbow: cell therapy biologics
15. Patellar tendinopathy: cell therapy
16. Patellar tendinopathy: biologics
17. Achilles tendinopathy: cell therapy
18. Achilles tendinopathy: biologics
19. Plantar Fasciitis: cell therapy
20. Plantar Fasciitis: biologics
21. Ligament lesions: cell therapy
22. Ligament lesions: biologics
23. Meniscal lesions: cell therapy
24. Meniscal lesions: biologics
25. Muscle lesions: cell therapy
26. Muscle lesions: biologics
27. Fractures (incl. Nonunions): cell therapy
28. Fractures (incl. Nonunions): biologics
29. Cartilage lesions and Osteoarthritis of the knee: cell therapy
30. Cartilage lesions and Osteoarthritis of the knee: biologics
31. Cartilage lesions and Osteoarthritis of the hip and ankle: cell therapy
32. Cartilage lesions and Osteoarthritis of the hip and ankle: biologics
III. Future directions 33. Pluripotent stem cells: Embryonic/Fetal stem cells and induced pluripotent stem (iPS) cells
34. Gene therapy
35. Stimulation of the intrinsic stromal cell niche
36 Conclusions.

Summary: "Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications. Covers the basic science clinicians need to know to understand the mechanisms of action of orthobiologic therapies for tissue repair and regeneration, as well as technology development, regulation, and the commercialization pathway Provides thorough discussions of current standards of care and clinical applications across all subspecialty areas, including upper and lower extremity pathology, as well as spinal pathology Uses a reader-friendly approach with more than 100 illustrations and dozens of helpful tables throughout Discusses options and solutions for intervertebral disc repair, spinal fusion, rotator cuff repair, peripheral nerve regeneration in the hand, challenging bone repairs and nonunion, skeletal muscle repair, meniscal repair and replacement, articular cartilage repair, knee and ankle osteoarthritis, ligament regeneration, and more. Enrich Your eBook Reading ExperienceRead directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech. "-- Provided by publisher.

Summary: For almost 20 years, clear aligners have been used with growing popularity in addressing with success patients' demands for esthetic orthodontic treatment. Many companies all over the world have developed methods of fabricating custom-made clear aligners designed to gradually and sequentially move teeth to their desired positions. Treatment efficacy with clear aligners has been reported to be good but further investigation of the various aspects of this kind of orthodontic treatment modality is needed for scientific evidence and further clinical improvement. This chapter presents an overview of the patients' esthetic treatment demands, which led to the popularity of this modality of orthodontic therapy, as well as important aspects of the clear aligner method, the orthodontic tooth movement with clear aligners, and the material properties of clear aligners. Clear aligner material efficiency and effectiveness should continue to be studied, as a better understanding of the material properties and treatment outcomes could lead to better sequencing of tooth movement and more efficient treatment.

Summary: This book reviews different treatment options for Cleft Lip and Palate problems emphasizing the cooperation between the areas of Orthodontics and Surgery. After an introduction to variations in cleft types, different CLP treatment plans are introduced and reviewed. The book represents some of the oldest and most thorough longitudinal documentation of cleft lip palate treatment. It is comprised of objective serial records using photos, dental casts, cephalographs and measurements. The last part of the book identifies pitfalls and complications in facial palate treatment. It discusses future directions and the importance of longitudinal facial and dental cast records. This book is intended to aid in the teaching of aspiring and practicing Orthodontists and Surgeons dealing with Cleft Lip and Palate problems. (TBE).

Contents:
Introduction to Cleft Lip Palate: The Normal Face and Facial Palatal Problems
Embryogenesis and Causes of Clefting
Variations in Cleft Types
Qualification of Cleft Team Members. Orthodontic and Surgical Treatment of Cleft Lip Palate: Presurgical Orthodontics
Molding Geometric Relationships
Palatal Surgery
Lip Surgery
Orthodontic Treatment to Reduce Anterior Openbite
Various Possible Treatments. Pitfalls and Future Directions in Cleft Lip Palate Treatment: The value of Longitudinal Facial & Dental Cast Records
The reasons for Success and Failure
Result of Early Surgical Setback
A Multicenter Retrospective
Questions to be answered
Conclusion.

Summary: This well-illustrated book is an up-to-date guide to orthodontic diagnosis, treatment planning, and treatment delivery in patients with obstructive sleep apnea (OSA). The aim is to present the latest knowledge on the important contribution that orthodontic modalities can now make in the management of a disorder that has generally been the preserve of sleep doctors. This book comprises three parts of general understanding of OSA and medical approaches, orthodontic diagnostic process, and orthodontic treatment application. In particular, the treatment parts are subdivided into six chapters depending on the patients phenotype and age groups. The readers will come to realize how many modalities are available beyond the previously well-known options, and how important orthodontic contributions are for the treatment of OSA patients. The book will be an excellent resource providing well-organized diagnostic and therapeutic protocols from orthodontic point of view and will also be of value to other practitioners with an interest in OSA.

Contents:
Orthodontic diagnosis & planning: Comprehensive understanding of OSA as orthodontists
Orthodontic diagnosis: Anatomic & functional evaluation of upper airway
Phenotype-based clinical pathway for orthodontic intervention. Orthodontic treatment modalities: Early growth modification of snoring children with mouth breathing
Functional training for OSA patients with mouth breathing
Treatment of OSA adults with transverse skeletal discrepancy: Nasomaxillary skeletal expansion (NMSE)
Treatment of OSA adults with skeletal deformity I: Mandibular advancement device (MAD)
Treatment of OSA adults with Skeletal deformity II: Maxillomandibular advancement (MMA) surgery.

Contents:
Foundations
Dental deep bites
Skeletal deep bites
Dental anterior open bites
Skeletal anterior open bites
Posterior open bites.

Summary: "This book reviews the convoluted history of orthogenesis with an emphasis of non-English sources, untangles relationships between various concepts of directed evolution and argues whether orthogenesis has something to offer modern biology. Darwinism claims that evolution occurs by selection from an extensive random variability. An alternative viewpoint--that the material for variability is limited and organisms are predisposed to vary in certain directions--is the essence of evolutionary concepts that can be grouped together under the name of orthogenesis. Dating back to Lamarck, orthogenesis has existed in many guises. Branded as mystical and discarded as unscientific, it keeps re-emerging in evolutionary discussions."-- Provided by publisher.

Contents:
Intro; Contents;
Chapter 1: Introduction; References; Part I: Orthogenesis: A History;
Chapter 2: The Sources. Formation of the Concept of Directed Evolution in the Nineteenth Century; References;
Chapter 3: Evolutionary Biology at the Turn of the Twentieth Century. New Concepts of Directed Evolution in the 1900-1930s; References;
Chapter 4: Declarations in Favour of Orthogenesis in the 1900-1930s; References;
Chapter 5: Orthogenesis and the Modern Evolutionary Synthesis; References;
Chapter 6: New Concepts of Directed Evolution in the Recent History of Evolutionary Biology; References.
Chapter 7: Statements in Support of Orthogenesis in the 1950s and LaterReferences; Part II: Orthogenesis: Pro et Contra;
Chapter 8: "Laws" in Biology; References;
Chapter 9: Species Senescence; References;
Chapter 10: Adaptation or Non-adaptation?; References;
Chapter 11: Anticipation, Parallelisms and Convergences; References;
Chapter 12: Constraints on Variation; References;
Chapter 13: Direct Impact of the Environment on Evolution and the Inheritance of Acquired Characteristics; References;
Chapter 14: Mystics or Unrealised Synthesis?; References;
Chapter 15: Conclusion; References; Index.

Contents:
1 Introduction: why orthogeriatrics, worldwide distribution of orthogeriatric approach
2 Epidemiology of hip fracture and social costs.-3 Osteoporosis in the elderly patient
4 Frailty, sarcopenia and falls
5 Pre-operative management
6 Hip fracture: the choice of surgery
7 Orthogeriatric anaesthetics. 8 Post-operative management
9 The role of nursing
10 Rehabilitation
11 Multi-professional team: coordination and communication
12 How to implement a Fracture Liaison Service
13 Co-management of elective orthopaedic patients
14 Patient's and caregiver's psychological evaluation.

Summary: "This edition represents the scientific basis of orthopaedic surgery as of 2020. It is intended to inform clinical decision making by providing the basic sciences in a clinically relevant context. The production of the fifth edition of Orthopaedic Basic Science was a substantial undertaking contributed to by each of the authors. The author list is comprised of senior scientists and clinicians, and rising stars, a healthy mixture that reflects well on both sustained personal commitments and expectations for the future. Reflecting the growth in orthopaedic scientific information, all the previously included chapters have been revised and many new chapters have been added. Molecular biology has been refocused to emphasize the role of epigenetics. Biomaterials, repair, and tissue engineering are also emphasized. The significance of articular crosstalk is presented together with new chapters on joint biology and osteoarthritis. Consideration of gender differences in preclinical and clinical studies recognizes the spectrum of biological responses and the presentation of metabolic bone diseases acknowledges the importance of secondary fracture prevention. A completely redone section on the generation of clinical information recognizes advances in methodology, the assessment of large databases and the growth of registries, and best-practice guidelines"-- Provided by publisher

Summary: This book presents a fundamental basic overview of orthopedic biomechanics in sports medicine, with a special focus on the current methodologies used in modeling human joints, ligaments, and muscle forces. The first part discusses the principles and materials, including the use of finite element analysis (FEA) to analyze the stress-strain response in the implant-bone interface and design. The second part focuses on joint-specific biomechanics, highlighting the biomechanics of the knee and shoulder joints, their modeling, surgical techniques, and the clinical assessment of joint performance under various kinematic conditions resulting from different repair techniques. Written by international experts working at the cutting edge of their fields, this book is an easy-to-read guide to the fundamentals of biomechanics. It also offers a source of reference for readers wanting to explore new research topics, and is a valuable tool for orthopedic surgeons, residents, and medical students with an interest in orthopedic biomechanics.

Contents:
Orthopaedic biomechanics principles and materials. Biomechanics applications.-Moment arms and Forces at the joints
Ligament
Bone
Articular cartilage
Fibrocartilage.-Tendon
Muscle
Application to Orthopaedics. Joint specific orthopaedic biomechanics. Anatomy and kinematics of the shoulder joint
Biomechanics of rotator cuff injury and repair
Biomechanics of shoulder instability and repair
Biomechanics of acromioclavicular joint injury and repair
The Throwers shoulder. General elbow biomechanics
The Throwers elbow
Elbow tendon injuries and repair
Biomechanics of hip
Biomechanics of femoroacetabular impingement
Biomechanics of soft tissue injuries around the hip
Anatomy and biomechanics of the knee
Anatomy and biomechanics of the anterior cruciate ligament biomechanics
Biomechanics of Extra-articular ligaments and tenodesis
Collateral ligaments.-PCL biomechanics
Biomechanics of Osteotomies around the knee
Meniscal biomechanics
Patellofemoral biomechanics
Biomechanics of the native knee as related to total knee design and function
Biomechanics of Cruciate retaining and Posterior stabilized
Biomechanics of UKA
Biomechanics of Ankle Joint
Biomechanics alteration in relation to ligament injuries
Biomechanics of tissue repair techniques. Biomechanics of bone grafts and bone substitutes
Biomechanics of cartilage repair
Biomechanics of stem cell treatment and regenerative medicine.

Summary: "A trusted radiology reference in its 7th edition that's established as an ideal comprehensive source for guidance for both radiologists and orthopedic surgeons on musculoskeletal imaging. It will retain its large trim size as is well regarded for the large images and very telegraphic style of the content. Curated by renowned musculoskeletal authorities over 3500 images that encompass conventional radiography, ultrasound, CT, dualenergy, CT, PET-CT and all other diagnostic imaging modalities used to evaluate musculoskeletal disorders, including numbers examples of 3-D imaging. And guidance provided on choosing the best imaging approach for each patient"-- Provided by publisher.

Summary: "This comprehensive orthopaedic resource covers all aspects of foot and ankle surgery in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Loretta B. Chou, MD, FAAOS, Orthopaedic Knowledge Update®: Foot and Ankle 7 presents relevant, evidence-based information, discusses its practical application, and provides supporting references, all tailored to the needs of today's practicing orthopaedists and trainees. Written, edited, and peer-reviewed by dedicated foot and ankle surgeons, it offers a complete guide to the diagnosis, treatment, and management of orthopaedic foot and ankle injuries and disorders, supported by the latest evidence"-- Provided by publisher.

Summary: "Foot and Ankle 6 is a blend of relevant information, the current application of knowledge, and supporting references in an all-inclusive foot and ankle resource. It spans all facets of foot and ankle surgery with concentrated coverage of significant developments from the past five years, as well as diagnosis, treatment, and management of orthopaedic foot and ankle injuries and disorders. Chapters are written, edited, and peer reviewed by experts in the field and supported by the latest evidence"-- Provided by publisher

Summary: "Orthopaedic Knowledge Update®: Hip and Knee Reconstruction 6 allows you to advance patient care with the best practices available. Explore the many changes in hip and knee arthroplasty in the past 5 years with updated material related to controversial topics, state-of-the-art technologies, and recent advances. The book is organized into three sections: basic and applied science relevant to both knee and hip arthroplasty; specific total knee arthroplasty topics; and specific total hip arthroplasty topics. Written by world-renowned experts in each subject, this edition features cutting-edge developments, as well as completely new chapters on thromboprophylaxis, outpatient surgery, pain management, retrieval-hip and knee, medical and biologic treatment of arthritis, nonarthroplasty management, infection, periprosthetic fracture, anatomy and surgical approaches, and dual-mobility cups and large-diameter heads for primary and revision total hip arthroplasty. Key study points are presented at the end of each chapter so you can quickly review important content. Orthopaedic surgeons with a specialty interest in hip and knee reconstruction, and physicians and allied health professionals interested in staying up to date will benefit from this edition. Residents in training can review key topics paired with helpful guidelines and images"-- Provided by publisher.

Summary: "Orthopaedic Knowledge Update®: Pediatrics 6 reflects the most recent clinical practice guidelines and appropriate use criteria, as well as the substantial number of high-quality studies in pediatric orthopaedics. This comprehensive multispecialty resource explores the latest advances in pediatric trauma, sports-related injuries, and upper and lower extremity conditions, with brand-new chapters on developmental biology, metabolism, high-energy injury and polytrauma, elbow trauma, knee trauma, and disaster response. Key study points are presented at the end of each chapter so you can quickly review important content. Recognized section editors and contributors bring fresh approaches and perspectives, with a focus on delivering a well-rounded update of this rapidly evolving subspecialty. This concentrated guide to new techniques, new approaches, and current controversies is ideal for anyone who treats pediatric musculoskeletal injuries"-- Provided by publisher.

Summary: "The field of shoulder and elbow surgery continues to rapidly expand and evolve. This fifth edition of Orthopaedic Knowledge Update® (OKU®): Shoulder and Elbow is focused on the most recent advances in this area of orthopaedics. It is written for practicing orthopaedic surgeons and presents, in a concise yet thorough manner, the most recent literature on the shoulder and the elbow and the advances in all areas of shoulder and elbow surgery. Shoulder and elbow specialists will also find this edition useful, along with residents and fellows, who will benefit from the knowledge and expertise of a world-class group of section editors and authors. New to this edition is an update on the design and biomechanics of reverse shoulder arthroplasty. New information on the biologics and indications and outcomes of these adjuncts to healing has been included. New chapters on the imaging of the shoulder specifically for the evaluation of the glenoid in instability and degenerative disease have been added. The chapter on complex regional pain syndrome and causalgia provides an update on current terminology, thought, diagnosis, and management. A chapter on both basic and advanced elbow arthroscopy is included. New information on management of elbow and shoulder injuries in throwing athletes is in this edition of OKU. In the past 5 years, the advent of the superior capsular reconstruction for rotator cuff-deficient shoulders has become more common. This edition brings the early science and results to the reader"-- Provided by publisher

Summary: "Orthopaedic Knowledge Update®: Sports Medicine 6 brings together the most relevant literature and the latest research from the past 5 years. More than 150 top-notch contributors collaborated on this succinct review of pertinent advances in sports medicine. Find brand-new content on hip instability and microinstability, return-to-play criteria following anterior cruciate ligament injury, exercise-induced bronchorestriction, development of emergency action plans, and imaging of the foot and ankle. Vivid illustrations help you fully comprehend new concepts, while expert section editors ensure a thorough yet unbiased presentation of relevant literature. Key study points are presented at the end of each chapter so you can quickly review important content. Whether you are an orthopaedic surgeon specializing in sports medicine, a physician assistant, physiatrist, or primary care physician, this is your go-to guide for diagnosis, treatment, rehabilitation, and beyond. Includes Surgical Techniques Video! In addition to providing guidance for managing challenging patient cases, this edition includes a link to access videos on the most in-demand and innovative surgical techniques in sports medicine. Close the time gap between reading content and applying innovative skills while expanding your surgical options"-- Provided by publisher

Summary: "Orthopaedic Knowledge Update, 13th edition, is a comprehensive synthesis of the latest clinical thinking and best practices across all the orthopaedic specialty areas. Backed by clinical research, informed by practical experience and rigorously edited by specialty thought leaders, OKU 13 is the most up-to-date resource available for delivering high-quality orthopaedic patient care today. With all new content, OKU 13 is an essential resource at every level of orthopaedic specialization"-- Provided by publisher

Contents:
The specialty of orthopaedic surgery / Abdullah Qatu, Kenneth A. Egol
Getting to know your patient / Stephanie Bazylewicz
Getting to know your patient / Stephanie Bazylewicz
Evaluation of the new patient / Stephanie Bazylewicz
Orthopaedic surgical patients : an overview / Ariana Lott, Kenneth A. Egol
Operative management / Avraham Schulgasser
Nonoperative orthopaedic conditions / Rebekah Belayneh, Kenneth A. Egol
Navigating the operating room / David Kugelman, Kenneth A. Egol
Administrative services / Monica Racanelli
Tips and tricks of the trade / Monica Racanelli
Office procedures / Kenneth A. Egol.

Summary: "Since its original publication, Orthopaedic Neurology: A Diagnostic Guide to Neurologic Levels has distinguished itself as a clearly written, uniquely focused text sought after by practitioners and trainees in orthopaedics, neurosurgery, physical medicine and rehabilitation, pain medicine, anesthesiology, neurology, and nursing, as well as primary care specialties. The second edition retains this standard of excellence while providing thorough updates in medical illustration, teaching techniques, and new approaches to the diagnosis and treatment of patients with spinal cord injuries. Now in vibrant full color, it offers a distinctive and practical combination of anatomy, the physical exam, and clinical pearls, highly readable and abundantly illustrated. Features:Discusses the diagnosis of neurologic levels according to common denominators, and combines them with the basic principles of neurology to assist in the appraisal of spinal cord and nerve root problems. Presents classic original drawings now carefully colorized for optimal visual reference, and additional drawings added as necessary. Corresponding radiographic imaging (predominantly MRI and CT) have also been added. Each chapter first covers basic neurologic information, then provides clinical significance by applying it to the diagnosis of the more common neurologic pathologies. Ideal for those who wish to understand more clearly the clinical concepts behind neurologic levels, moving systematically from concept to practice, and from general rules to specific applications."--Provided by publisher.

Contents:
Pt. 1: Nerve root lesions by neurologic level
Evaluation of nerve root lesions involving the upper extremity
Evaluation of nerve root lesions involving the trunk and lower extremity
Pt. 2: Spinal cord lesions by neurologic level
Cervical cord lesions: tetraplegia
Spinal cord lesions below T1, including the cauda equina
Meningomyelocele.

Contents:
Cover
Title
Copyright
Contents
Contributors
Preface
Pass Guarantee
Chapter 1: Orthopaedic Nurse Certification: Benefits, Planning, and Preparation
Benefits of Certification
Certification Requirements
Certification Renewal
Certification Exam Study Guide
Chapter 2: Musculoskeletal Anatomy and Physiology
Introduction
Anatomy and Physiology of the Musculoskeletal System
Anatomy and Physiology of the Shoulder
Anatomy and Physiology of the Elbow and Forearm
Anatomy and Physiology of the Hand and Wrist
Anatomy and Physiology of the Spine Anatomy and Physiology of the Hip
Anatomy and Physiology of the Knee
Anatomy and Physiology of the Foot and Ankle
Knowledge Check: Chapter 2
Chapter 3: Assessment of the Musculoskeletal System
Introduction
General Physical Examination
Fractures
Shoulder Examination
Elbow and Forearm Examination
Wrist and Hand Examination
Spine Examination
Hip Examination
Knee Examination
Foot and Ankle Examination
Holistic Assessment
Knowledge Check: Chapter 3
Chapter 4: Laboratory and Imaging Studies in Orthopaedics
Introduction
Laboratory Diagnostics Radiographic Studies
Biopsies
Knowledge Check: Chapter 4
Chapter 5: Principles of Perioperative Care
Introduction
Teamwork and Patient Safety
Preoperative Assessment and Planning
Intraoperative Care
Postoperative Care and Evaluation
Knowledge Check: Chapter 5
Chapter 6: Degenerative Disorders
Introduction
Osteoarthritis
Degenerative Disc Disease
Tendinosis
Osteoporosis
Paget's Disease
Rheumatoid Arthritis
Knowledge Check: Chapter 6
Chapter 7: Orthopaedic Trauma
Introduction
Synopsis and Definition
Signs and Symptoms Assessment and Holistic Evaluation
Psychosocial Considerations
Nursing Considerations
Complications and Adverse Outcomes
Knowledge Check: Chapter 7
Chapter 8: Sports Injuries
Introduction
Ankle Sprains
Achilles Tendonitis
Patella Tendonitis
Anterior Cruciate Ligament Tear
Medial Collateral Ligament Tear
PCL Tear
Meniscus Tear
Hip Labral Tear
Lumbar Disc Herniation
Rotator Cuff Tendonitis
Ulnar Collateral Ligament Sprain
Tennis/Golfer's Elbow
Knowledge Check: Chapter 8
Chapter 9: Inflammatory Disorders
Introduction Polymyalgia Rheumatica
Gout
Rheumatic Fever
Lyme Disease
Seronegative Spondyloarthropathies
Systemic Sclerosis
Systemic Lupus Erythematosus
Fibromyalgia Syndrome
Knowledge Check: Chapter 9
Chapter 10: Metabolic Bone Disorders
Introduction
Osteoporosis
Osteomalacia
Hyperparathyroidism
Hypoparathyroidism
Paget's Disease
Knowledge Check: Chapter 10
Chapter 11: Congenital/Pediatric Disorders
Introduction
Achondroplasia
Blount's Disease
Cerebral Palsy
Hyperparathyroidism
Club Foot
Developmental Dysplasia of the Hip

Summary: "The updated third edition of Orthopedic Pathology is a comprehensive, practical guide to diagnosing musculoskeletal disorders, offering details on the pathologic and radiologic characteristics of all bone and joint diseases. Highlighted by more than 1,700 high-quality illustrations, it focuses on helping you reach an accurate diagnosis for virtually any orthopedic disorder you're likely to encounter." -- Back cover

Contents:
Basic science of bone
Skeletal and extraskeletal calcification and ossification syndromes
Metabolic bone disease. Part I
Metabolic bone disease. Part II
Osteomyelitis and septic arthritis
Bone cysts and giant-cell tumor
Periosteum
Fibrous lesions
Bone forming bone tumors and tumor-like lesions
Cartilage tumors
Vascular and other mesenchymal tumors and lesions
Bone manifestations of hematologic disorders and small-cell tumors / Vincent J. Vigorita, and Jeffrey F. Lipton
Metastatic bone disease / Vincent J. Vigorita, and Jeffrey F. Lipton
Osteonecrosis
Synovium
Arthritis
Joint arthroplasty pathology
Soft tissue pathology
Commonly performed orthopaedic procedures / Adam Phillip Breceda, Eli Bryk, Vincent Vigorita.

Summary: "The concept behind the Orthopaedic Rotations Survival Guide has been inspired by you-the students, residents, and colleagues-with whom we have worked alongside and from whom we have learned so much. The editorial team has carefully curated content experts who are leaders in their fields and dedicated educators genuinely committed to advancing your understanding of orthopaedics. Along with each of the content experts, the editorial team is passionate about encouraging your interest in orthopaedics. The Orthopaedic Rotations Survival Guide edited by Amiethab A. Aiyer and William N. Levine, represents an extension of our commitment to your interest in musculoskeletal patient care. Furthermore, whether you are considering a career in orthopaedic surgery, physical therapy, athletic training, or otherwise, the goal of this text is to provide you with a "one-stop shop" resource for high-yield information as you move between learning experiences in the clinic or in the operating room. The primary goal of this text is to provide readily accessible information on topics that are high yield for anyone interested in orthopaedics. The text is designed to teach key principles in musculoskeletal education ranging from history and physical examination pearls to important nuances of planning and advanced imaging, to surgical approach considerations across all major orthopaedic subspecialties. Each chapter is accompanied by select recent literature to further broaden your breadth of knowledge"-- Provided by publisher.

Contents:
The orthopaedic physical examination / Matthew A. Varacallo,, Jonathan R. Kaplan
Imaging / Yoshimi Endo, Carolyn M. Sofka, Hollis G. Potter
I fell and cannot get up : lower extremity trauma / Alexandra K. Schwartz, Samir Mehta, Giselle M. Hernandez, Theodore T. Guild, John Y. Kwon, Fernando E. Vilella, Danielle C. Marshall, Diane Ismat Ghanem, Babar Shafiq
I fell and cannot use my upper extremity / Robert Z. Tashjian, Nicole S. Schroeder
My shoulder hurts : now what? / William N. Levine, Julianne Munoz
My elbow hurts / Charles M. Jobin, Charles Cassidy
My hand hurts / Dawn M. LaPorte, Seth D. Dodds
My hip hurts / Aaron Gipsman, Eric Strauss, Matthew A. Varacallo
My knee hurts / Joseph D. Lamplot, Robert H. Brophy
I need a joint replacement / Melvyn A. Harrington, Jr, Javad Parvizi, Matthew Blue, Graham Goh, Brian I. Nwannunu
My foot and ankle hurt / Lauren E. Geaney, Jonathan R. Kaplan, MaCalus V. Hogan
Spine : my back is killing me / S. Elizabeth Ames, Emmanuel Menga
Tumor ABCs / Tessa Balach, Cara A. Cipriano, Sheila Ann Conway, Ginger E. Holt
Pediatrics / Monica Kogan, Brian Scannell, Mara S. Karamitopoulos.