BookAyman F. El-Kattan.
Contents:
Drug pharmacokinetics and toxicokinetics
GIT anatomy and physiology and drug oral bioavailability : impact of species differences
Drug routes of excretion
Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion
Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect
Impact of intestinal efflux transporters on oral absorption
Impact of influx transporters on drug
Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery
In vitro and in situ approaches to measure intestinal permeability and efflux transporters
In silico approaches to predict intestinal permeability
In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption
In vitro approaches to assess haptic metabolism and first pass effect
The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.