Bookedited by Ajit S. Narang, Ph.D. (Department of Pharmaceutical Sciences, ORIC Pharmaceuticals, Inc, South San Francisco, CA, USA) & Ram I. Mahato, Ph.D. (Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA).
Summary: "This book provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, in relation to the advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate deep scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watch outs, limitations, and 'bookend' boundaries involved in the stages of testing and development. With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets"-- Provided by publisher.
Contents:
Section I: In-vitro and Ex-vivo Methods
Estimating Clinically Relevant Measures of Inhaled Pharmaceutical Aerosol Performance with Advanced In Vitro and In Silico Methods / Conor A. Ruzycki, Warren H. Finlay, and Andrew R. Martin
In Vitro Assessment of Drug Release, Dissolution, and Absorption in the Lung / Rajan S. Bhattarai, Virender Kumar, Ajit S. Narang, and Ram I Mahato
Lung-on-a-Chip and other Organoid Models / Muhammad H. Malik, Shalaleh Masoumi, Xue Zhou, and Xinli Liu
Interaction between Inhalable Nanomedicines and Pulmonary Surfactant / Chuanbin Wu
Section I: Particle Design Understanding
Particle engineering for pulmonary drug delivery / Vikram Karde and Jerry Y.Y. Heng
Particle Architectonics for Pulmonary Drug Delivery / Kohsaku Kawakami
Engineered Particles for Aerosolisation and Lung Deposition / Rachel Yoon Kyung Chang and Hak Kim Chan
Section IV: Novel Technologies
Recent advances in inhalable nanomedicine for lung cancer therapy / Hadeer M. Abdelaziz, Mohamed Teleb, Sherine N. Khattab, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed O. Elzoghby
Thin-Film Freeze-Drying Process for Versatile Particles for Inhalation Drug Delivery / Chaeho Moon, Sawittree Sahakijpijarn, and Robert O. Williams III
Nanoparticles as specific drug carriers to the lungs / Thaís Larissa do Amaral Montanheiro, Karla Faquine Rodrigues, Renata Guimarães Ribas, Vanessa Modelski Schatkoski, Raissa Monteiro Pereira, and Gilmar Patrocínio Thim
Section IV: Advancing Established Technologies
Surface modification of micronized drug particles for aerosolization / Tania Bajaj, Vishav Prabhjot Kaur, Urvashi Anwekar, Deepak Chitkara, Charan Singh
Spray Dried Particles for Inhalation / Raj Kumar, Neha Kumari, and David Oupicky
Inhalation Aerosol Phospholipid Particles for Targeted Lung Delivery / Basanth Babu Eedara, David Encinas-Basurto, Don Hayes Jr, and Heidi M. Mansour
Nebulizers / Ariel Berlinski
Protein and Peptide Delivery to the Lung via Inhalation / Xin, Wang, Kumar, Narang and Mahato
Exosomes Based Drug Delivery for Lung Cancer Treatment / Rajagopal and Munshi