Books

Summary: This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

Contents:
Urine is a better biomarker source than blood especially for kidney diseases
Urine reflection of changes in blood
Urimem facilitates kidney disease biomarker research
Human Urine proteome: a powerful source for clinical research
Exosomes in urine biomarker discovery
Urinary proteins with post-translational modifications
Applications of peptide retention time in proteomic data analysis
Urine Sample Preparation in 96-Well Filter Plates to characterize inflammatory and infectious diseases of the Urinary Tract
Variations of human urinary proteome
Evolution of the urinary proteome during human renal development and maturation
Hormone-dependent changes in female urinary proteome
Effects of exercise on the urinary proteome
Effects of Diuretics on Urinary Proteins
Applications of urinary proteomics in renal disease research using animal models
The application of urinary proteomics for the detection of biomarkers of kidney diseases
Dynamic changes of urinary proteins in focal segmental glomerulosclerosis model
Using isolated rat kidney to discover kidney origin biomarkers in urine
Comparing plasma and urinary proteomes to understand kidney function
Urinary Protein Biomarker Database: A Useful Tool for Biomarker Discovery.

Summary: This book is comprehensive resource and up-to-date description of all urinary sediment constituents which are presented in bright-field mode and in phase-contrast mode. Thanks to numerous detailed images of urinary sediment constituents, the reader is able to easily compare what they view microscopically with high-resolution photographs and short films. The book is also designed to aid the identification of rare urine constituents in their native state without prior staining. It also features guidance to microscope setup, microscopy techniques, preanalytics. Exercises focused on microscopic analysis and diagnosis and a urinary sediment quiz reinforce key concepts to aid learning. Urine Sediment provides a practically applicable guide to the recognition of urinary sediment constituents. It is therefore a critical resource for trainees and experienced practitioners in urology, nephrology, gynecology and general practice who need to be able to accurately and quickly identify urine sediment constituents.

Contents:
Intro
Foreword
Preface
Acknowledgments
Contents
Abbreviations
About the Author
Part I
1: The Microscope
1.1 Structure of the Microscope
1.2 Cleaning and Maintaining the Microscope
1.3 Servicing the Microscope
1.4 Light Bulb Replacement
2: Setting-Up Köhler Illumination
2.1 Setting-Up Köhler Illumination or Aligning the Microscope
2.2 Quick Guide to Setting-Up Köhler Illumination
Reference
3: Phase-Contrast Microscopy
3.1 Application
3.2 What Is Required for Changeover?
3.3 The Light Pathway of Phase-Contrast Microscopy 3.4 Phase-Contrast Microscopy Equipment
3.4.1 PhaCo Objective
3.4.2 PhaCo Condensers
3.5 Centering the Phase Rings
4: Macroscopic Urinalysis
4.1 Color
4.1.1 Some Examples
4.2 Odor
4.2.1 Some Examples
4.3 Cloudiness
4.3.1 Some Examples
5: Microscopic Urinalysis
5.1 Urine Sediment Preparation
5.1.1 Performance
5.2 Error Checklist and Tips for Urine Sediment Preparation
5.3 Discussion: Types of Centrifuge (Fig. 5.2)
5.4 Centrifuge Nomogram
5.5 Preparing the Native Sample
5.5.1 Materials (Fig. 5.4)
5.5.2 Performance 5.6 Switching the Microscope Between Bright-Field and Phase-Contrast
5.6.1 Switching the Microscope from Bright-Field to Phase-Contrast Microscopy
5.6.2 Switching the Microscope from Phase-Contrast to Bright-Field Microscopy
5.7 Specimen-Specific Adjustment of the Microscope
5.8 Semi-quantitative Analysis/Units
5.9 Discussion: Field Number and Normal Values
6: Anatomy of the Kidneys and Urinary Tract System
7: Description of Urinary Sediment Constituents
7.1 Erythrocytes
7.1.1 Hematuria (Increased Excretion of Erythrocytes in Urine) 7.1.2 Eumorphic Erythrocytes-NR: 0-1/HPF
7.1.2.1 Biconcave, Disc-Shaped Erythrocytes (pH = 6)
7.1.2.2 Thorn Apple-Shaped Erythrocytes (pH 6)
7.1.3 Dysmorphic Erythrocytes
7.1.4 Acanthocytes-NR: <5%
7.2 Leukocytes
7.2.1 Leukocytes-NR: 1-4/HPF
7.2.2 Special Forms of Leukocytes
7.2.2.1 Sternheimer-Malbin Cells or Bright Cells
7.2.3 Histiocytes (Macrophages)-NR: None
7.3 Epithelial Cells
7.3.1 Squamous Epithelial Cells-NR: 0-15/HPF
7.3.2 Transitional Epithelial Cells or Urothelial Cells-NR: 0-1/HPF 7.3.3 Deep Urothelial Cells-NR: None
7.3.4 Renal or Tubular Epithelial Cells-NR: None
7.3.5 Oval Fat Bodies-NR: None
7.3.6 Virus-Infected Cells
7.3.6.1 Example: Decoy Cells-NR: None
7.3.7 Discussion: Cell Description
7.3.7.1 Criteria
7.3.8 Discussion: Morphological Criteria of Old Cells and Epithelial Cells
7.4 Casts
7.4.1 Hyaline Casts-NR: Isolated
7.4.2 Granular Casts-NR: None
7.4.3 Waxy Casts-NR: None
7.4.4 Renal Epithelial Casts-NR: None
7.4.5 Erythrocyte Casts-NR: None
7.4.6 Leukocyte Casts-NR: None

Summary: Urine tests are used by a variety of primary care providers and specialists in order to diagnose, monitor and treat patients with various medical conditions. This first-of-its-kind text is a comprehensive clinical guide to the evaluation and application of urine tests. Clinical cases are used to highlight important aspects of urine testing. Further evaluation and management are then discussed based on the results of the urine tests. Topics covered include financial considerations, regulations, proper collection, testing methods, dipstick analysis, microscopy as well as cancer and drug screening tests, among others. Each chapter contains specific objectives for focus of study. Pertinent images, algorithms and board style review questions for important topics are also included. Written by nephrologists, urologists, other specialists and primary care physicians, Urine Tests uses a comprehensive approach to the clinical use of both common and uncommon urine testing. Primarily appealing to practicing primary care physicians, this book is also a useful resource for specialists, nurse practitioners, physician assistants, physician fellows, residents and medical students alike.

Contents:
Intro
Preface
Abbreviations
Contents
Editor Bios
Contributors
Chapter 1: Urine: The Golden Elixir of Life
Overview
Urine Production
Urine Refinement
Urine Elimination
Summary
References
Chapter 2: Follow the Money: Costs, Reimbursement and Regulations of Urine Based Testing
Overview
Costs
Reimbursement
Regulations
Additional Considerations
Future Directions
Summary
References
Chapter 3: Going with the Flow: Proper Urine Testing Methods for Clinical Practice
Overview
Case 1: Urine Specimen Collection Methods of Urine Collection
Random (Routine) Specimen
First Morning Specimen
Timed Collection
Midstream "Clean-Catch" Specimen
Catheterized Specimen
Suprapubic Aspirate
Ordering of Urine Tests
Case 2: Urine Dipstick Versus Urine Microscopy
Methods of Urine Testing
Methods for Chemical Screening
Methods for Examination of Urine Sediment (Microscopy)
Automated Urinalysis
Case 3: Special Urine Testing
Pregnancy and Ovulation Testing
Urinary Calculi
Cytopathologic Examination
Summary
References Chapter 4: Urine Dipstick: Blood
The Spectrum of Red
Overview
The Urine Dipstick Test for Blood
Sensitivity/Specificity
When Is it Appropriate to Check Urine for Blood?
Case 1: Positive Dipstick for Blood, Negative Microscopy for Red Blood Cells
Case 2: Positive Dipstick for Blood, Positive Microscopy for Normal Shaped Red Blood Cells
Case 3: Positive Dipstick for Blood, Positive Microscopy for Dysmorphic RBCs
Summary
References
Chapter 5: Urine Dipstick: Proteinuria - Causes, Consequences and Diagnostic Approach
Overview The Pathophysiology and Significance of Proteinuria
Case 1: Dipstick Positive Proteinuria in a Healthy/Low Risk Patient
The Dipstick Analysis
Urine Protein Quantification
Urine Albumin to Creatinine Ratio
Transient Causes of Proteinuria
Proteinuria Indicative of Intrinsic Kidney Disease: Nephrotic versus Nephritic Proteinuria
Case 2: Nephrotic Proteinuria
Nephrotic Syndrome
Case 3: Nephritic Proteinuria
Nephritic Syndrome
When Is a Kidney Biopsy Indicated?
Case 4: Proteinuria Screening Indications
Patients Requiring Routine Screening for Proteinuria Treatment of Proteinuria
Summary
References
Chapter 6: Urine Dipstick: Urinary Nitrites and Leukocyte Esterase - Dipping into Murky Waters
Overview
Interpretation: Clinical Context
Case 1: Asymptomatic Bacteriuria
Case 2: Use of Urine Nitrites in Clinical Diagnosis
Case 3: Use of Urine Leukocyte Esterase in Clinical Diagnosis
Additional Approaches to Interpreting Urine Dipsticks
Summary
References
Chapter 7: Urine Dipstick: An Approach to Glucosuria, Ketonuria, pH, Specific Gravity, Bilirubin and Urobilinogen - Undeniable Chemistry
Overview

Summary: This book provides a unique insight and background of a uro-oncology nurse's career from a personal and professional perspective, one that encapsulates the ever changing dynamics in the nursing profession over 40 years - 1970-to current, 2022. In writing this book, the objective is to devise a beneficial point of reference, one that is conducive to enlightening individuals within the healthcare profession and the wider context, on the art of reflection and acknowledging its benefits in terms of exploring their feelings and understanding their meaning. Reflection is a highly beneficial tool. In this context, the process enables the author to reflect constructively on her nursing career and practice, to highlight the positive as well as the negative aspects within that practice, and illustrate how the experiences gained have contributed to her development, personally and professionally, throughout that journey. Reflection includes deliberate reflection on experience, emotions, actions and responses and acknowledging how essential these have been to informing the author's existing knowledge base and in ensuring a higher level of learning and understanding. In the continued quest to deliver optimal healthcare, the objective of reflection is in enabling healthcare individuals e.g. nursing students, newly qualified nurses or those considering change of nursing speciality, to better understand their patients from a holistic standpoint (physical, psychological, psycho-social, spiritual, cultural and economic) and ultimately, improving the individual patient'soverall experience--cancer or otherwise, as well as improving and enhancing practice outcomes. The importance of reflection and its contribution to increasing the healthcare professional'sself-awareness--emotional, personal and professional, is also well underlined. Various Modules and Case Studies within the book are used to explain and highlight key issues, and to enhance content and visual acuity.

Contents:
Preface.-Acknowledgments
Chapter 1. Introduction.-Chapter 2 The Early years
Chapter 3 The changing dynamics of nursing: a personal and professional experience of nearly 50 years
Chapter 4 A Constructive interlude in my career path
Chapter 5 Urology Nursing: Accentuating my experiences of the principles of practice.-A perspective on uro-oncology management and highlighting the MUCNS role in this management
Chapter 7 Educational and practical aids to enhancing practice
Chapter 8 Coping with the "breaking of bad news"-personal and professional perspectives
Chapter 9 Penultimate reflections.-Chapter 10 A final reflection of my clinical practice journey.-Appendices.

Summary: This book aims to provide a guide for urodynamic investigation in individuals who have suffered spinal cord injuries. It is universally acknowledged that this type of investigation is valuable and most international guidelines consider it mandatory in patients with neurogenic bladder dysfunction. The book offers an evidence based knowledge of applicability, clinical value, and limitation, and will give the reader strong diagnostic outcomes that will benefit patients suffering from spinal cord injuries. What is presented in this book is based on expert opinions acquired over decades of urodynamic testing that have taken place in different parts of the world.

Contents:
1. Introduction
2. Physiology and pathophysiology
3. Diagnosis of neurogenic LUT dysfunction after SCI
4. Techniques of UDT
5. Performing UDT
6. Data obtained from UDT
7. 40 cm H₂O
8. Training
9. When to perform UDT after SCI
10. When to repeat UDT
11. Complications of UDT
12. Indications to postpone UDT
13. Special UDT tests
14. Rules to get proper results of UDT
15. Value of UDT
16. Different types of intravesical pressure development
17. Urodynamic tracings with full medical files
18. Data sets
References.

Summary: This pocket guide is an easy-to-use, practically oriented resource that provides reliable information and advice on the technical aspects of urodynamic techniques, the interpretation of tracings, quality control, and the most common pitfalls. Individual sections focus on uroflowmetry, multichannel urodynamics, interpretation of pressure/flow tracings, urethral function studies, pelvic floor electromyography, videourodynamics, and urodynamics of the upper urinary tract. Despite recent criticisms, there is general agreement that urodynamic investigation represents a necessary step before any surgical approach to incontinence and obstruction. Nevertheless, recently published guidelines fail to provide specific directions on performance and interpretation of urodynamics, and knowledge of the basic rules and formal urodynamics training are too often lacking. Readers will find that this guide enables them to retrieve key information quickly and to feel more confident in their practice of urodynamics.

Contents:
The framework of basic science
Key symptoms analysis and diagnostic algorithms
Physical examination and laboratory evaluation
Urodynamic testing: when and which
Voiding diary and Pad testing
Non-invasive urodynamics
Conventional urodynamics-conventional urodynamics in pediatric age
Electromyogtrahy
Urethral profilometry
Videourodynamics
Ambulatory urodynamics
Urodynamics of upper urinary tract.

Summary: This book offers gynecologists and urogynecologists a pocket guide to urodynamic testing in women with lower urinary tract symptoms. In female urology, the main indications for urodynamics are urinary incontinence, pelvic organ prolapse, urgency-frequency syndrome (also known as overactive bladder), emptying disorders and painful bladder. By collecting quantitative measurements while reproducing the patient's voiding symptoms where appropriate and possible, urodynamics helps to identify the cause of symptoms, supports management and facilitates prognoses. However, despite the undeniable advantages, the role of urodynamics in female urology is hotly debated. The book starts by describing the physiological background and methodological considerations for urodynamic best practice in the preclinical setting. It then explains how to perform urodynamics correctly - so-called "good urodynamic practice" - to increase the readers' confidence and ability to perform and interpret urodynamic investigations. Lastly, it reviews the advantages and disadvantages of urodynamic testing in each of the key clinical female urology conditions. A separate chapter focuses on the peculiarities of diagnosis and management for female patients with neurogenic bladder. This guide offers a valuable tool for gynecologists, urologists and urogynecologists, as well as a ready source of information for all physicians involved in diagnosing and treating lower urinary tract disorders in women.

Contents:
Physiology of micturition in female
How to perform urodynamic investigation: the good urodynamic practice
Urodynamics in stress urinary incontinence
Urodynamics in pelvic prolapse
Urodynamics in overactive bladder
Urodynamics in emptying problems
Urodynamics in chronic pelvic pain
Neurogenic bladder in female.

Summary: This book provides an up to date, comprehensive, review of the common urogenital painful conditions. It will serve as a valuable resource for clinicians, urologists, surgeons, gynecologists, palliative care physicians, and many other medical providers. The book reviews presenting signs and symptoms, diagnostic workup, differential diagnoses, interventional treatments, and alternative medical therapy for painful conditions that occur in the urogenital region. The text also provides a clear understanding of how pain is transmitted along with what patient populations are at increased risk in suffering these conditions. The risks, benefits, and indications are discussed in detail for the variety of interventional injections that are available to help manage these conditions.

Summary: This heavily revised third edition concisely covers the latest evidence-based treatment strategies for urinary incontinence and prolapse. Chapters cover methodologies relevant to continence procedures, prolapse management, and potential complications. New topics discussed include Colpocleisis, principles associated with managing Mesh complications and the Mirabegron mechanism. Urogynecology: Evidence-Based Clinical Practice 3rd Edition is a vital how-to guide, which is ideal for junior registrars assigned to work in a urogynecology department, as well as for those with no previous formal urogynecological training seeking to develop their understanding of the subject.

Contents:
History taking
Physical examination
How to manage the patient after history and examination
How to conduct and interpret urodynamic tests
Outcome measures in assessing response to treatment
Conservative therapy of USI
Step by step guide to treatment of overactive bladder / detrusor overactivity
Faecal Incontinence and Disorders of Obstructive Defecation
Surgery for USI
Management of Prolapse
Recurrent bacterial cystitis in women
Interstititial cystitis?.

Summary: Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.

Contents:
A History of Histories
Epistemology and Lithology
Laboring Under the Stone: A Literary Legacy of Lithiasis
Paleolithology
Greco-Roman Stone Disease
Dark Ages, Dark Therapies
Renaissance of Urolithiasis
van Beverwijck-The Bridge from Ancient to Modern
Enlightened Minds and Stone Disease
Charlatans, Quacks & Joanna Stephens
Evolution of Stone Disease
Founding Fathers of Stone Chemistry
Famous Stone Sufferers
Frederik Ruysch's Fascination With Urolithiasis
Gray's Anatomy of Stones: Henry Vandyke Carter
The Stone Hospital & Stone Treatment
Liesegang's Rings
Lithotomy
Litholapaxy- Civiale to Bigelow, von Kern controversy (1828)
Imaging the Beast- Sounding, Lithoscopes and Rentgen Rays
Rise of 'Science' in Stone Disease
Fictitious Stones and Sir William Osler
Early Modern Stone Disease
Epidemiology
Pathophysiology
The Rarest Stone of All!
The Largest Stone of All!
Lithotripsy: From Rocket Science to the Clinic
Modern Stone Science
Equal Rights: Stone Disease and Females
Urologist's Guide to the Galaxy
Towards Keeping the Hippocratic Oath (Six Sigma).

Summary: This book serves as a concise guide to urinary stone disease, providing simplified and complete information about the topic area. Various surgical techniques are provided and accompanied by first-hand accounts, to give insight into the operating room. The book is a quick reference guide and is relevant to both trainees and professionals. Written by a leading expert in the field, this book brings together years of experience and contains essential information on all aspects of lithology. The book covers all treatment options so that the best possible methods can be chosen for each patient. Urinary stone disease is a widespread ailment and updated information about it is permanently needed by trainees and professionals.

Summary: "Urologic health care problems are often very complex, and nurses who treat these issues practice in a wide range of settings with patients across the lifespan. The urologic nursing specialty requires its professionals to have a comprehensive knowledge of developmental and aging changes that are essential to understanding acute and chronic urologic diseases. Urologic Nursing: Scope and Standards of Practice meets this need by defining and describing the scope of practice, educational preparation, certification, and practice environment/population focus of the urologic registered nurse (RN) and advanced practice registered nurse (APRN). The standards also outline current challenges to urologic nursing and the competencies all urologic nurses are expected to attain"--Publisher's description.

Contents:
Introduction
Scope of urologic nursing practice
Professional registered nurses today: the how of urologic nursing
Standards of urologic nursing practice
Standards of practice
Standards of professional performance
Scopes and standards glossary.

Summary: This comprehensive and timely textbook covers all aspects of the evidence-based management of genitourinary cancers and explains the fundamental principles underlying the available diagnostic and treatment approaches, including chemotherapy, radiotherapy, immunotherapy, and surgery. For each type of cancer – prostate, bladder, renal, testicular, and penile, plus rare urologic malignancies – clinical presentation, diagnosis, and treatment strategies are described in detail and information is provided on etiology, epidemiology, risk factors, and pathology, including TNM classification. Careful attention is also devoted to the complications that may be encountered when treating urologic malignancies and to the management of these complications. The text is complemented by the inclusion of numerous high-definition photographs and illustrations. Urologic Oncology will be a valuable reference and source of guidance for all oncologists, urologists and practitioners in related disciplines who treat patients with urologic cancers. -- Provided by publisher.

Contents:
Intro; Preface; Contents; About the Editors; Editorial Board; Contributors; Part I: Introduction; 1 Molecular Basics on Genitourinary Malignancies; Introduction; Prostate Cancer; Urothelial Carcinoma of the Bladder and Upper Urinary Tract; Kidney Cancer; Penile Cancer; Testicular Cancer; References; 2 Clinical Aspects and Investigations in Genitourinary Cancer; Principles of Common Radiological Investigations; X-Ray; Intravenous Urography (IVU); Ultrasound; Computed Tomography; Magnetic Resonance Imaging (MRI); Bone Scans; PET (Positron Emission Tomography) Scans; Renal Cell Carcinoma Clinical AspectsInvestigations; Laboratory; Imaging; Ultrasound; Appearance; Computed Tomography; MRI; Urothelial Cancer; Clinical Aspects; Presentation; Investigations; Laboratory; Imaging; CT Urography; Ultrasonography; MR Urography; Prostate Cancer; Clinical Aspects; Presentation; Investigations; Prostate-Specific Antigen (PSA); Other Biomarkers; Imaging; Ultrasound; MRI; CT Scan; Bone Scan; Positron Emission Tomography (PET); Testicular Cancer; Clinical Aspects; Presentation; Examination; Imaging; Ultrasonography; Tumor Markers; CT Scan; MRI and Bone Scan; PET; Penile Cancer Clinical AspectsPresentation; Premalignant Lesions; Invasive Cancer; Investigations; References; 3 Clinical Trials and Their Principles in Urologic Oncology; Introduction; Principles of Drug Development; Overview of Trial Designs; Types of Clinical Trials; Phases of Clinical Trials; Preclinical, Phase 1, and Phase 2 Trials; Phase 3 Trials; Phase 4 Trials and Post-Marketing Assessment; Design of Clinical Trials; Research Question and Hypothesis; The Patient Population; Definition of a Comparator; Calculating the Right Sample Size; Planning Statistical Analysis; Endpoints of Clinical Trials Primary and Secondary EndpointsComposite Variables and co-Primary Endpoints; Surrogate Endpoints (SEP); Patient-Reported Outcomes (PROs) and Endpoints and their Increasing Relevance in Clinical Trials; Adverse Event and Patient-Reported Outcomes (PROs) Reporting in Clinical Trials; Conducting the Trial in the Best Possible Way: How to Avoid Bias; Randomization; Blinding; Stratification; Clinical Trial Oversight; The Ethical Foundation of Clinical Trials; Principle of Equipoise; Ethical Considerations Within Clinical Trials in Urology Precision Medicine, Genomics, and Molecular Testing in Clinical TrialsThe Relevance of Genomic Research for Urological Cancers and for Clinical Trials in Uro-Oncology; Opportunities and Challenges in Cancer Genomic Research in Urological Tumors; Specific Considerations Related to Clinical Trials in Uro-Oncology; Medical Tumor Treatment; Caveats for Randomized Clinical Trials in Urologic Oncology Surgery; Measuring Outcome and Reporting in Uro-Oncology Trials; Final Considerations and Summary; Take-Home Messages; References; 4 Bone Target Therapy in Urologic Malignancies; Introduction

Summary: Urologists and medical oncologists have witnessed a rapid growth in systemic therapeutic options for treating genitourinary malignancies that increasingly integrates radiation therapy to primary cancers, nodal beds, and even metastatic sites. The culmination of these advances has been the creation of multidisciplinary teams that expertly provide comprehensive care to patients with urologic cancers. This book provides the framework to create such a multidisciplinary clinical team focused on the treatment of urologic malignancies with representation from urologists, medical oncologists, and additional specialists who work together to provide optimal team-based care. The book integrates advanced systemic therapeutics including immune-based and targeted therapies. Readers gain a better understanding of the benefit of multidisciplinary co-management through specific examples such as hormone sensitive metastatic prostate cancer, neoadjuvant chemotherapy for muscle invasive bladder cancer, and immunotherapy approaches to advanced bladder and kidney cancer. The book also discusses the integration of genomic tumor characterization and personalized medicine into surgical planning, tumor biopsies, and chemo-immunotherapy selection, emphasizing the expansion of new therapeutics for urologic malignancies and the changing definitions of disease progression. Urologic Oncology: Multidisciplinary Care for Patients is a comprehensive resource for urologists, medical oncologists, radiation oncologists, genetic counselors, fellows in urologic oncology and medical oncology, residents in urology and radiation oncology, advanced practice providers, practice managers, and pharmaceutical representatives. .

Summary: This volume focuses on aspects of urology which are often forgotten in contemporary practice, but are nevertheless the subject of incremental advances and form the basis of much of the non-oncological practice. It covers numerous topics including laparoscopy.

Summary: This book provides a practical guide to the use of the latest applicable surgical procedures and present novel pathways. It details how to utilize a range of techniques including three-dimensional (3D) laparoscopy and those that require robotic assistance. Guidance is also contained on innovative tools including confocal laser endomicroscopy along with the application of biomaterials, artificial intelligence and other exponential technologies, enabling the reader to systematically develop a thorough understanding of these methodologies. Urologic Surgery in the Digital Era: Next Generation Surgery and Novel Pathways systematically reviews the application of the latest surgical techniques and potential future developments in urology. Therefore, it is a critical resource for all practicing and trainee urological surgeons.

Contents:
Part-1: Novel pathways to next generation surgery. Robotic-Assisted Surgery
Stone Treatment
BPH
Bladder Cancer
Robotic Upper Tract Surgery
3D Camera-Assisted Open Surgery
Kidney Transplantation
3D Laparoscopy
Sacral Neuromodulation
Injections and Biomaterials
Confocal Laser Endomicroscopy
Live Surgery and Safety Standards
Part-2: Future perspectives. Artificial Intelligence
Social Media and E-Learning
Aviation and Non-Technical Skills
Exponential Technologies and Future Scenarios.

Contents:
Nonneoplastic diseases of the kidney
Neoplasms of the kidney
Renal pelvis and ureter
Fine needle aspiration of the kidney
Nonneoplastic disorders of the urinary bladder
Neoplasms of the urinary bladder
Urine cytology
Nonneoplastic diseases of the prostate
Neoplasms of the prostate
Seminal vesicles
Urethra
Nonneoplastic diseases of the testis
Neoplasms of the testis
Spermic cord and testicular adnexa
Penis and scrotum
Adrenal glands.

Contents:
The Evolution of Therapy for Chronic Pelvic Pain
The Changing Role of Organized Patient Support for the Chronic Pelvic Pain Patient
Practical Psychosocial Management of Urologic Chronic Pelvic Pain Syndromes,
Advanced Practice Nursing Care for the Pelvic Pain Patient
Diet Therapy in the Context of Chronic Pelvic Pain
The Role of Acupuncture in the management of Chronic Pelvic Pain
Phytotherapy in Chronic Pelvic Pain
Management of Interstitial Cystitis/Bladder Pain Syndrome with Tricyclic Antidepressants
Bladder Surface Mucin Analogues
Neuroleptic Agents for Chronic Pelvic Pain
Anti-allergic Compounds in Chronic Pelvic Pain
Opioids and Related Medications
Hormonal Therapy for Pelvic Pain
Non-curgical Management of Vulvar Pain
Immunomodulators for Interstitial Cystitis/Bladder Pain Syndrome
Other Oral Agents for Chronic Pelvic Pain
Nerve Blocks
Intravesical Therapy for Bladder Pain Syndrome/Interstitial Cystitis: Dimethyl Sulfoxide
Intravesical Lidocaine in Interstitial Cystitis/Bladder Pain Syndrome
Innovative Intravesical Therapies
Endoscopic Procedures for Interstitial Cystitis/Bladder Pain Syndrome
Botulinum Toxin Endoscopic Injection for Pelvic Pain
Neuromodulation
Cystectomy/Supravesical Diversion for Interstitial Cystitis
Surgery for Vulvovaginal Pain Disorders and Dyspareunia
The Surgical Management of Scrotal Pain
Therapy for Interstitial Cystitis/Bladder Pain Syndrome and Other Forms of Pelvic Pain During Pregnancy.

Contents:
Part 1. Prostate Cancer
1. Epidemiology, Etiological factors, Prevention
2. PSA Biology and Prostate Cancer Screening
3. Symptoms, Signs, Clinical Examination, Primary Diagnostic Methods and Disease Extention Investigations
4. Prostate Cancer Treatment.- Part 2. Bladder tumour
5. Epidemiology, Pathology, Etiological factors, Prevention, Screening, Symptoms and Signs
6. Investigations (Lab and Radiology)
7. Bladder Tumour Treatment
8. Non-Urothelial Bladder Cancers
Part 3. Upper Tract Urothelial Carcinomas
9. Epidemiology, Risk Factors, Pathology, Tumour Staging
10. Diagnosis of UTUC
11. Treatment of UTUC, Prognosis and Follow-Up
Part 4. Renal Cell Carcinomas
12. Epidemiology, Etiology
13. Pathology, Genetic Profile, Hereditary Syndromes
14. Clinical Features
15. Physical Examination, Laboratory and Radiological Investigations
16. Treatment of Renal Cell Carcinomas.- Part 5. Male Genital Cancer
17. Epidemiology and Etiology of Testicular Cancer
18. Histological Classification of Testicular Cancer
19. Clinical Presentation of Testicular Tumours and Spreading Patterns.- 20. Diagnostic Approaches of Testicular Cancer
21. Staging and Risk Categories of Testicular Cancer
22. Treatment of Testicular Cancer
23. Extra-Gonadal Germ Cell Tumours
24. Penile Cancer.- Part 6. Adrenal Gland Cancer
25. Epidemiology, Aetiological Factors, Symptoms and Signs of Adrenocortical Carcinomas (ACC)
26. Investigations of ACC
27. Treatment of Adrenal Gland Cancer
28. Malignant Pheochromocytoma
Part 7. Clinical Scenarios
29. Scenarios and Questions
30. Proposed Answers.

Summary: This text creates a framework for the integration of urological care into the long-term management of patients with progressive neurological conditions. It begins with a general review of the neuroanatomy and physiology of the bladder, followed by a discussion of common techniques for evaluating bladder and upper tract function, and the general principles of bladder management in patients with neurogenic bladder disease. Section II narrows the scope of each chapter to focus on specific neurological disorders such as Parkinson's Disease, Alzheimer's Disease, Dementia, and Cerebral Palsy. Each chapter begins with a brief synopsis of the neurologic basis of each disease, followed by its most common urologic manifestations, specific recommendations for urologic care in each disease state, and finally a recommended pathway for integrated long-term care of these patients based on available evidence and expert opinion. The final section of the text reviews the generalized care of patients with advanced disease, including palliative and end of life options, focusing on urologic interventions. Urological Care for Patients with Progressive Neurological Conditions will be an invaluable resource for urologists, neurologists, and all health care providers treating patients with neurological diseases.

Contents:
Introduction
Basic Bladder Physiology, Anatomy, Common Urologic Terms
Neuroanatomy
Measuring QOL in Degenerative Conditions
Urodynamic Studies
Urologic Imaging
Common Bladder Management Strategies for Patients with Neurogenic Bladder Disease
Parkinson's Disease and Multisystem Atrophy
Alzheimer's Disease/Lewy Body Dementia
Cerebral Palsy
Huntington's Chorea
MS and Other Demyelinating Disorders
ALS
Friedrich's Ataxia
Spinal Muscle Atrophy
Lambert Eaton
Diabetes
Care for Patients with Limited Mobility
Goals and Limits of Care.

Summary: This book is designed to familiarize general urologists with the care of transgender and gender non-conforming individuals. Written by experts in reconstructive urology, it characterizes the process of gender affirmation and explains the surgical anatomy of both feminizing and masculinizing gender-affirming procedures including vaginoplasty, orchiectomy, hysterectomy, vaginectomy, phalloplasty, metoidioplasty, and prosthetics. Guiding the clinician in identification of immediate and long-term risks of gender-affirming surgery, it instructs clinicians in endocrinological care, options for fertility preservation, evaluation of malignancies after hormonal therapy, appropriate postsurgical follow-up, and the management of common complications involving urethral stricture, fistula, neo-vaginal stenosis, and incontinence. Urological Care for the Transgender Patient: A Comprehensive Guide is a necessary tool to prepare urological clinics and clinicians in serving the growing population of transgender patients presenting at various stages of their transformation.

Contents:
The Current State of Transgender Care
Decision-Making Challenges For Patients and Surgeons Regarding Genital Gender Affirming Surgery
Endocrinological Care for Patients Undergoing Gender Affirmation (including Risk of Thromboembolic Events)
Preoperative Preparation and Perioperative Considerations for Gender-affirming Genital Surgery
Surgical Anatomy: Orchiectomy and Fertility Preservation Options
Surgical Anatomy: Vaginoplasty
Complications of Vaginoplasty
Surgical Anatomy
Hysterectomy and Vaginectomy: Hysterectomy for the Transgender Man
Surgical Anatomy: Metoidioplasty
Surgical Anatomy: Phalloplasty
Management of Urologic Complications Following Metoidioplasty and Phalloplasty
Prosthetics (Erectile Implant, Testicular Implants)
General Urological and Endourological Considerations in the Care for Transgender Patients (Catheters, Scopes, Haematuria, UTI, Stones, Surgical Positioning)
Care of the Transgender Patient: Oncological Concerns
Care of the Transgender Patient: Incontinence
The Role of Physical Therapy in the Care of the Transgender Patient
Regrets in Transgender Female: Reversal Phalloplasty
Robotic Applications in Gender Confirming Genital Surgery
Brief History of Gender Affirmation Medicine and Surgery.

Summary: With a fully updated look at urological cancers and a comprehensive approach to the basic principles behind chemotherapy, radiotherapy and gene therapy, Urological Oncology, 2nd Edition addresses the advances in MRI, hormone therapy, anesthesia for minimally invasive surgery, drug trials, new therapeutic techniques as well as the new histological types of renal cancer, bringing this second edition fully up-to-date with current practices. Through investigations and multidisciplinary management, Urological Oncology, 2nd Edition reflects the editors? vast experience in treating all urological cancers, and the broad international contributions reflect the urological oncology practice in other developed countries including the United States. Urological Oncology, 2nd Edition will be a valuable tool for residents, specialists, nurse practitioners and other medical personnel in Urology, Radiotherapy, Oncology and Palliative Medicine involved in the treatment of urological cancers.

Contents:
1. Normal Cell
2. Experimental Urological Oncology: Cellular, Molecular, and Animal
3. Genetics and Genito-Urinary Cancer
4. Principles and Design Considerations of Clinical Trials
5. Non-Interventional Imaging in Genitourinary Cancer
6. Nuclear Medicine in Urological Cancer
7. Clinical Emergencies in Genito-Urinary Cancers
8. Clinical Aspects of Urological Cancers Including Haemanatospermia
9. Renal Failure, Dialysis and Transplantation: In the Management of Renal Cell Carcinoma (Solitary Kidney and Bilateral Renal Tumors)
10. Diet and GU Cancers
11. The Anesthetic Management of Patients with Genitourinary Cancer
12. Laparoscopy and Robotic-Assisted Laparoscopy in Uro-Oncological Surgery
13. Principles of Chemotherapy for Genytourinary Cancer
14. Principles of Radiotherapy in Genito-urinary Cancers
15. Palliative Care in Urological Cancer
16. Life After Urological Cancer: Psychological Issues
17. Renal Cell Carcinoma Overview
18. Renal Cancer: Epidemiology and Aetiology
19. Pathology of Renal Cancer
20. Renal Cancer: Clinical Features
21. Renal Cancer: Investigations and Staging
22. Renal Cancer: Surgical Management
23. Nephron-Saving Procedures: Ablative Techniques (Non-Surgical) Radiofrequency Ablation (RFA), High-Intensity Focused Ultrasound (HIFU), Cryotherapy
24. Medical Management of Metastatic Renal Cell Carcinoma
25. Tumors of the Adrenal Gland
26. Epidemiology, Biology, and Genetics of Adult Male Germ Cell Tumors
27. Pathology of Testicular Tumors
28. Testicular Cancer: Clinical Features, Staging, and Surgical Management
29. Chemotherapy for Testicular Cancer
30. The Role of Radiotherapy in Testicular Cancer
31. Management of Superficial Bladder Cancer
32. Intravesical Therapy for Bladder Cancer
33. Molecular Biology of Urothelial Cancer
34. Invasive Bladder Cancer: Combined Modality Treatment
35. Surgical Management of Bladder Cancer
36. Management of Metastatic Bladder Tumors
37. Surgical and Minimally Invasive Management of Upper Urinary Tract Tumors
38. Urachal and Urethral Cancer (Excluding Penile Cancer)
39. Epidemiology, Screening, Pathology and Pathogenesis
40. Clinical Presentation, Diagnosis and Staging
41. Expectant Management of Localized Prostate Cancer
42. External Beam Radiation Therapy for Clinically Localized Prostate Cancer
43. Brachytherapy for Prostate Cancer
44. Cryotherapy for Prostate Cancer
45. High Intensity Focused Ultrasound (HIFU) in Prostate Cancer
46. Surgical Aspects of Prostate Cancer Management
47. Management of Locally Advanced Prostate Cancer
48. Castrate Resistant Prostate Cancer: Systemic Chemotherapy and a System Program
49. The Hormonal Management of Metastatic Prostate Cancer
50. Cancer Penis and Scrotum
51. Non-Urological Cancers Affecting the Urinary Tract.

Summary: Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds, and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations, many of them in color, are also included. The editors and authors are leading urological surgeons and oncologists and internationally recognized authorities in their fields. This book will be a great asset in every urologist?s office and will also prove invaluable for practitioners in related disciplines.

Summary: The book covers all relevant topics of uropathology (tumoral and non-tumoral), from the normal histology of the genitourinary tract to pathological findings of diseases in the male genital and urinary tract. To make the content more accessible, all content is arranged alphabetically and each entry is uniformly structured, presenting the epidemiology, the clinical signs, the gross and histological features, the immunohistochemical stainings, and the molecular data for each disease. Histological pictures clarify the microscopic findings and help readers understand the differential diagnosis for genitourinary tract diseases. In addition to internationally respected experts on pathologies of the prostate, bladder, kidney and testis, researchers coming from other disciplines such as molecular biologists, soft tissue pathologists, dermatopathologists, hematopathologists and gynaecopathologists have contributed to this book, thus making it interesting for uropathologists, but also for students, residents, clinicians (surgeons, radiotherapists, oncologists, urologists, dermatologists) and researchers who deal with disciplines that call for knowledge of the pathologies of the male genital and urinary tracts.

Summary: Urticaria is one of the most common diseases encountered in dermatology. The fleeting nature of wheals often makes a first diagnosis by both patients and physicians seem easy. The disease itself is of a highly complex nature, with a variety of clinical manifestations ranging from pinpoint sized wheals to extensive angioedema. Further complexities include the diversity of possible eliciting and aggravating factors, the many different clinical subtypes and the therapeutic responsiveness. This second, extensively revised edition includes the indications listed in the most recent international guidelines, provides a practical, comprehensive review of all clinical aspects and causes, and addresses the diagnosis and therapy of different types of urticaria. Specific chapters are devoted to classification, aetiopathogenesis, patient reported outcomes, acute urticaria, chronic urticaria and its comorbidities, angioedema without weals, inducible urticarias, special populations including children, treatment with antihistamines and omalizumab, other interventions and looking ahead to new therapies. This new edition is a must read for dermatologists, allergists, pediatricians and practitioners of all disciplines who want their patients to benefit from cutting-edge diagnostics and treatments.

Contents:
1. History of Urticaria
2. Aetiopathogenesis of urticaria
3. Classification and diagnosis of Urticaria
4. Impact of chronic urticaria and how to measure it
5. Acute Urticaria
6. Chronic spontaneous Urticaria
7. Chronic spontaneous urticaria & co-morbidities
8. Inducible urticarias
9. Angioedema
10. Management principles in urticaria
11. Antihistamines
12. Omalizumab in the treatment of urticaria
13. Other interventions for chronic urticaria
14. Urticaria in pediatrics and during pregnancy and lactation : highlights on epidemiology , diagnosis and management
15. Urticaria Therapy and Management. Looking Forward.

Summary: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.

Summary: The world famous classic by the originator of the Alexander Technique. Over a century has passed since F.M. Alexander discovered that most people stood, sat and moved in a defective manner. As a result, he pioneered a revolutionary method of improving the 'use' of our bodies in all positions and movement: the Alexander Technique. His method is now practiced around the world and is renowned for its wide-ranging benefits, from easing back pain, to enhancing performance in music and drama. In this new edition, leading Alexander teacher Anthony Kingsley introduces the text to a modern audience and shows why now, more than ever, there is value to be found in this life-changing praxis.

Contents:
A new perspective by Anthony Kingsley
Preface
Preface to new edition (1941)
Evolution of a technique
Use and functioning in relation to reaction
The golfer who cannot keep his eyes on the ball
The stutterer
Diagnosis and medical training.

Summary: A forty-year tightening of funding for scientific research has meant that resources are increasingly directed toward applied or practical outcomes, with the intent of creating products of immediate value. In such a scenario, it makes sense to focus on the most identifiable and urgent problems, right? Actually, it doesn't. In his classic essay "The Usefulness of Useless Knowledge," Abraham Flexner, the founding director of the Institute for Advanced Study in Princeton and the man who helped bring Albert Einstein to the United States, describes a great paradox of scientific research. The search for answers to deep questions, motivated solely by curiosity and without concern for applications, often leads not only to the greatest scientific discoveries but also to the most revolutionary technological breakthroughs. In short, no quantum mechanics, no computer chips. This brief book includes Flexner's timeless 1939 essay alongside a new companion essay by Robbert Dijkgraaf, the Institute's current director, in which he shows that Flexner's defense of the value of "the unobstructed pursuit of useless knowledge" may be even more relevant today than it was in the early twentieth century. Dijkgraaf describes how basic research has led to major transformations in the past century and explains why it is an essential precondition of innovation and the first step in social and cultural change.

Contents:
The world of tomorrow / Robbert Dijkgraaf
The usefulness of useless knowledge / Abraham Flexner.

Contents:
The hermaphrodite of Charing Cross / Anita Guerrini
Galvanic humans / Rob Iliffe
The subject as instrument : galvanic experiments, organic apparatus and problems of calibration / Joan Steigerwald
Shocking subjects : human experiments and the material culture of medical electricity in eighteenth-century England / Paola Bertucci
Pneumatic chemistry, self-experimentation and the burden of revolution, 1780-1805 / Larry Stewart
Food fights : human experiments in late nineteenth-century nutrition physiology / Elizabeth Neswald
Experimenting with radium therapy : in the laboratory & the clinic / Katherine Zwicker
Anthropometry, race, and eugenic research : "Measurements of growing Negro children" at the Tuskegee Institute, 1932-1944 / Paul A. Lombardo
Nazi human experiments : the victims' perspective and the post-Second World War discourse / Paul Weindling
A eugenics experiment : sterilization, hyperactivity and degeneration / Erica Dyck.

Summary: This guide provides a concise overview of central neuromodulators and psychological therapies, and their use in managing patients with disorders of gut-brain interaction. The text demonstrates how central neuromodulators can help disordered gut function and reviews choices of drugs for different disorders, along with dosages and recommendations on their use. The book also outlines the use of cognitive behavioral therapy and exposure therapy in treating these patients, and presents a tutorial on how internal medicine physicians should approach the use of psychiatric medications. Written by experts in the field, Using Central Neuromodulators and Psychological Therapies to Manage Patients with Disorders of Gut-Brain Interaction: A Clinical Guide is a valuable resource for clinicians and practitioners on how to treat and manage patients afflicted with disorders of gut-brain interaction.

Summary: "Occupational therapy (OT) models provide a structured way of assessing unique contexts, such as relationships, location and cultural considerations, and how these will affect the approach to care. Written by leading experts in this field, Using Occupational Therapy Models in Practice provides a comprehensive overview of OT models and how to use them."--Provided by publisher.

Summary: This book is the first comprehensive research and practice-based guide for understanding and assessing supervision technology and for using it to improve the breadth and depth of services offered to supervisees and clients.

Summary: "A question bank in book format, USMLE Step 1 Integrated Vignettes is a concise, portable tool that will help you bridge the gap between preclinical coursework and Qbank usage. The focus is on integrated cases and differential diagnoses, along with practical clinical correlations."--Page 4 of cover.

Contents:
Hematopoietic and lymphoreticular system
Nervous system and special senses
Musculoskeletal system
Endocrine system
Cardiovascular system
Respiratory system
Gastrointestinal system
Renal and urinary system
Male respiratory system
Breast and female reproductive system
Vignette diagnoses.

Contents:
Section 1. Autonomic Pharmacology
Section 2. Cardiovascular Pharmacology
Section 3. Neuropharmacology
Section 4. Antibiotics
Section 5. Pharmacokinetic and Pharmacodynamic Principles.

Contents:
1. History of Adenomyosis
2. The Incidence and Clinical Significance of Adenomyosis
3. The Pathophysiology of Adenomyosis
4. The Myometrium in Heath and Disease
5. The Role of the Myometrium in Adenomyosis
6. The Endometrium in Adenomyosis.- 7. The Animal Model of Adenomyosis
8. Improving the Preclinical Mouse Efficacy Studies of Adenomyosis
9. Adenomyosis and Ultrasound: the Role of Ultrasound and its Impact on Understanding the Disease
10. Adenomyosis and Endometrial Carcinoma
11. Myometrial Cystic Adenomyosis
12. Current Treatment for Adenomyosis.

Summary: There are more than 63,000 new cases of uterine and endometrial cancer each year in the United States, up from approximately 41,000 when the first edition of Uterine Cancer was published in 2009. A book focusing on these cancers was timely, with emergent sophistication in diagnosis increasingly impacting clinical decision-making. However, five years later, the need for an updated book on this topic is even stronger as oncologists recognize opportunities to impact the outcome on women that are increasingly diagnosed with these malignancies. Uterine Cancer: Screening, Diagnosis, and Treatment, Second Edition, part of the Current Clinical Oncology series, enhances the awareness on this somewhat neglected area of therapeutics, helping to integrate targeted therapies into the management of women with uterine cancer. Written by experts in the field in a highly practical and comprehensive manner, it is a must-have for all gynecological residents and fellows, as well as gynecological oncologists, medical oncologists, radiation oncologists, and family practice doctors who wish to provide their patients with the best possible care.

Summary: This volume provides a broad background of the basic sciences, clinical and therapeutic aspects, and management of uterine cervical cancer. It offers state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the uterine cervix, and provides a better understanding of the molecular and cellular events that underlie uterine cervical cancer. Uterine Cervical Cancer: Clinical and Therapeutic Perspectives contains extensive, updated information on the promising new developments in the diagnosis and management of uterine cervical cancer. It will serve as an invaluable resource for all clinicians and basic medical scientists caring for women with uterine cervical cancer, including attending surgeons, physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.

Contents:
Epidemiology of Cervical Cancer
Prevention of Cervical Cancer
Current Advances in Optical Screening for Cervical Cancer
Cervical Cancer Screening in Low and Middle Income Countries
Pathology and Molecular Diagnosis of Cervical Cancer and Precursor Lesions
Uterine Cervical Cancer in Woman with HIV Infection
Immunotherapy for Pre-Cancerous Lesions of the Uterine Cervix
Utility of Sentinel Node Biopsy in Cervical Cancer
Fertility Sparing Surgery for Early Stage Uterine Cervical Cancer
Standard and Novel Surgical Treatments in Cervical Cancer. Management of Recurrent Uterine Cervical Cancer
Chemotherapy for Cervical Cancer
Potential Biomarkers for Personalized Radiation Therapy for Patients with Uterine Cervical Cancer
Radiotherapy for Uterine Cervical Cancer
Quality of Life in Woman with Cervical Cancer
Index.

Summary: This volume elucidates state-of-the-art findings of uterine fibroids and adenomyosis, incorporating expert basic knowledge. Uterine fibroids and adenomyosis are common uterine tumors in reproductive-age women. However, the pathogenesis of the tumors is still poorly understood, and both genetic and environmental factors may be involved in their generation or development. Recent research on the genomics and molecular biology of uterine fibroids and adenomyosis has facilitated a better understanding of the pathogenesis and pathophysiology of these benign tumors. Renowned experts provide detailed discussions of basic research and clinical aspects of uterine fibroids and adenomyosis in this book, from histopathology and molecular pathogenesis to diagnosis and the latest treatment of uterine fibroids, including pregnancy complications of adenomyosis. A great deal of information and a deep understanding of molecular and genetic biology have led to development of more innovative treatments of these tumors. Thus this book benefits not only oncologists, seasoned gynecologists, and obstetricians, but also molecular biologists and other basic researchers who are involved in the treatment of uterine fibroids.

Contents:
1 Histopathology of uterine fibroids
2 Genetics and genomics of uterine fibroids
3 Molecular pathogenesis of uterine fibroids
4 Stem cells and uterine fibroids
5 Epigenetics and uterine fibroids
6 Biomarkers of uterine fibroids
7 Current medical treatments for uterine fibroids
8 Diagnostic imaging for uterine fibroids, adenomyosis and uterine sarcomas
9 Pathogenesis of adenomyosis
10 Adenomyosis and subfertility
11 Surgical treatments for adenomyosis
12 Pregnancy complications of adenomyosis.

Summary: This book is the first comprehensive text on utilization management in the clinical laboratory and other ancillary services. It provides a detailed overview on how to establish a successful utilization management program, focusing on such issues as leadership, governance, informatics, and application of utilization management tools. The volume also describes ways to establish utilization management programs for multiple specialties, including anatomic pathology and cytology, hematology, radiology, clinical chemistry, and genetic testing among other specialties. Numerous examples of specific utilization management initiatives are also described that can be imported to other heath care organizations. A chapter on utilization management in Canada is also included. Edited by an established national leader in utilization management, Utilization Management in the Clinical Laboratory and Other Ancillary Services is a valuable resource for physicians, pathologists, laboratory directors, hospital administrators, and medical insurance professionals looking to implement a utilization management program. .

Contents:
Healthcare Reform and its Impact on Medical Reimbursement
Utilization management in the clinical laboratory: an introduction and overview
Effective Governance Structure and Management of Utilization Programs
Informatics, Analytics and Decision Support in Utilization Management
Utilization Management Employing Test Interpretations and Algorithms
Calculating Costs and Savings in Utilization Management
Benchmarking and Management Metrics in Utilization Management
Laboratory Formularies
Utilization and Other Resource Management in Clinical Chemistry
Utilization Management in the Routine Hematology Laboratory
Patient Blood Management
Utilization Management of Blood Derivatives
Utilization Management in the Clinical Microbiology Laboratory
Utilization Management in a Large Community Hospital
Utilization Management: The Role of Reference Laboratories
Utilization Management in Anatomic Pathology
Utilization Analysis in Hematopathology
Laboratory Utilization
Test Utilization: Controlling costs in Reference Laboratory Testing
Utilization Management of Genetic Testing
The Use of Physician Profiling and Prior Approval (Gatekeeping) in Utilization Management in the Clinical Laboratory
Test utilization: The Essential Role of the Clinical Consultant
The Role of the Genetic Counselor in Utilization Management
Utilization Management in Radiology
Strategies for the Clinical and Financial Management of Drug Utilization
Laboratory Utilization Management in Canada
Utilization Management Initiatives That Can Be Imported into Health Care Systems. .

Summary: This book demonstrates how a novel decision-aid, called a Benefit-Risk Characterization Theater (BRCT), can be used to: | Significantly improve accurate communication of health risks from exposure to COVID-19; and | Assess how to best contain and control COVID-19. To date, there have been far-reaching ramifications based on ineffective risk communication when clarifying these health endpoints. A BRCT is a familiar, theatrical chart representation of 1,000 people, with the risks and benefits shown by blackened seats. Since health outcomes can easily be put into such a chart, we show how BRCTs can be used objectively by professionals, the media and lay people. It allows characterization and communication of health benefits and risks of COVID-19 treatment and containment in an undemanding and straightforward way. BRCTs have been successfully used to assist patients in determining: | Their level of acceptable risk of various medical interventions; | If the benefits of intervention outweigh the risks; | Who should make the final decision regarding medical intervention; and Whether the decision is evidence-based. Written by experts in the field, this book fills in a gap in communication between the medical community, the public and patients. It also provides an area of expertise in communication that is beneficial for medical providers and medical students.

Contents:
PART I: Communicating Risk and Benefit in the Medical Community
Patients, Doctors and Decision-making
Absolute and Relative Risks
Communicating health risks to patients and the public
Erik's Recent Experience with Doctors and a Heart Attack
Why not all numbers are the same
Putting BRCTs to use in helping people understand health outcomes
PART II: Videos to Describe the Utility of BRCTs
PART III: COVID-19 Communication
Segue to Part III: BRCTs & COVID-19
How important are the number of cases?
The demographics of COVID-19
Why COVID-19 Should Not Have Prevented Colleges (and Elementary and Secondary Schools) from Opening Last Fall
Nursing homes, the nidus of COVID-19 death
The use of universal masking
Communicating about the impact of surges and quarantines
Communicating about the adverse effects of the cure
How we communicate about COVID-19 in other countries
Other viral pandemics with reference to COVID-19
A Path Forward: BRCTs for COVID-19 and Beyond.

Summary: This book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases. Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.

Contents:
Molecular Basis of Uveal Melanoma and Emerging Therapeutic Targets
Clinical/Commercial
Genetic Testing in UM
BAP1 Tumor Predisposition Syndrome
Pathology of Uveal Melanoma
Epidemiology of Uveal Melanoma and Potential Clusters
Gene Expression Profiling in the Management of Uveal Melanoma
Surgical Considerations of Radiation Plaques and Enucleation
Uveal Melanoma: Imaging
Radiation Therapy in Ocular Melanoma
Late Complications of Radiation Therapy in Uveal Melanoma
Nanoparticles for the Treatment of Uveal Melanoma
Screening Schedules for Metastatic Disease
Adjuvant Therapy of Uveal Melanoma Liver-Directed Therapies for Hepatic Metastases
Systemic Therapy for Metastatic Uveal Melanoma
Cell Therapy for Uveal Melanoma.

Summary: This book discusses the main clinical aspects of common uveitic infectious and non-infectious entities, the diagnostic work-up, and the treatment/management options based on the literature, where available, and clinical experience. Providing a quick reference guide to uveitis and retina fellows as well as general ophthalmologists, this comprehensive book includes chapters on diagnostic biopsy and pediatric uveitis, as well as reference tables and figures. As part of the series "Current Practices in Ophthalmology" this book is intended for residents, fellows-in-training, generalist ophthalmologists and specialists alike.

Contents:
Non-infectious anterior uveitis
Infectious anterior uveitis
Non-infectious intermediate, posterior, panuveitis
Infectious intermediate, posterior, panuveitis
Diagnostic testing in uveitis
Imaging in uveitis
Surgery in uveitis
Diagnostic biopsy in uveitis
Pediatric uveitis.

Summary: "Developed at Philadelphia's world-renowned Wills Eye Hospital, the Color Atlas and Synopsis of Clinical Ophthalmology series covers the most clinically relevant aspects of ophthalmology in a highly visual, easy-to-use format. Vibrant, full-color photos and a consistent outline structure present a succinct, high-yield approach to the seven topics covered by this popular series: Cornea, Retina, Glaucoma, Oculoplastics, Neuro-Ophthalmology, Pediatrics, and Uveitis. This in-depth, focused approach makes each volume an excellent companion to the larger Wills Eye Manual as well as a practical stand-alone reference for students, residents, and practitioners in every area of ophthalmology. The updated Uveitis volume includes: Authoritative information on all the major aspects of ocular inflammatory disease, including both ocular and systemic manifestations of each disorder, ideal for busy practicing ophthalmologists, ocular immunologists, residents, and rheumatologists.^More examples and variations of disease, clinical illustrations using new imaging modalities, and expanded treatment options. Newly characterized conditions, such as uveitis due to Ebola virus and Zika virus. More than 450 new and updated high-quality illustrations that detail the clinical features of each disorder, illustrate pathogenesis, and assist in visual diagnosis. An easy-to-use format that covers Epidemiology and Etiology, History, Physical Examination, Differential Diagnosis, Laboratory and Special Examinations, Diagnosis, Prognosis, and Management. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device, such as computer, tablet, or smartphone Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages Easily convert to audiobook, powering your content with natural language text-to-speech.^Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"--Provided by publisher

Contents:
Machine-generated contents note: Immune response overview / Sunir J. Garg
Anatomic classification of uveitis / Wendy M. Smith, Lisa J. Faia, Sunir J. Garg, and H. Nida Sen
Episcleritis, scleritis, and keratitis / Shilpa Kodati, H. Nida Sen, Theresa Larson, S.R. Rathinam, Rajesh Vedhanayaki, Muhammad Rakibuz-Zaman, William Hodge, Somasheila I. Murthy, Swapnali Sabhapandit, and Roxana Ursea
Anterior uveitis / Julie Gueudry, Bahram Bodaghi, Phuc LeHoang, Karina Julian, and Sunir J. Garg
Cataract- and lens-induced uveitis / Swapnali Sabhapandit, Somasheila I. Murthy, Mayank Mahajan, and Anita Schadlu
Intermediate uveitis / Andrea D. Birnbaum, Anjum F. Koreishi, and Debra A. Goldstein
Posterior uveitis and collagen vascular diseases / Sapna Gangaputra, H. Nida Sen, Rishi R. Doshi, S.R. Rathinam, Emmett T. Cunningham, Jr., Sunir J. Garg, Robert W. Wong, S.R. Rathinam, Virginia Miraldi Utz, and Johnny Tang
White dot syndromes / Cline Terrada, Bahram Bodaghi, Kisha D. Piggott, P. Kumar Rao, Sapna Gangaputra, Matthew A. Cunningham, Steven Yeh, Annal D. Meleth, Jaclyn L. Kovach, Janet L. Davis, and Jason Hsu. Infectious posterior uveitis / Karina Julian, Bahram Bodaghi, Phuc LeHoang, P. Vijayalakshmi, Rim Kahloun, Moncef Khairallah, Sunir J. Garg, Lalitha Prajna, S.R. Rathinam, Bryn Burkholder, Shilpa Kodati, H Nida Sen, Julie Gueudry, R. Vedhanayaki, Vishali Gupta, Sarakshi Mahajan, Sapna Gangaputra, Chloe Gottlieb, Uwe Pleyer, Val?rie Touitou, Carlos Alexandre de Amorim Garcia Filho, Carlos Alexandre de Amorim Garcia, Jason F. Okulicz, Kim Ramasamy, and Rajesh S Priya
Endophthalmitis / Stephen G. Schwartz, Harry W. Flynn, Jr., Roy D. Brod, Manohar Babu Balasundaram, S.R. Rathinam, Bahram Bodaghi, and Phuc LeHoang
AIDS-related eye disease / Annal Meleth, Sapna Gangaputra, and H. Nida Sen
Drug-induced uveitis / Kara C. LaMattina, Nehali V. Saraiya, and Debra A. Goldstein
Masquerade syndromes / H. Nida Sen, Bahram Bodaghi, Carol L. Shields, Henry Wiley, Sapna Gangaputra, Ann O. Igbre and Sunir J. Garg
Treatment of uveitis / Sam S. Dahr, Shilpa Kodati, Theresa Larson, and H. Nida Sen.

Contents:
v. 1. Differential diagnosis
v. 2. Therapy.

Summary: Focusing solely on uveitis care, this quick reference guide will provide a compiled and easy to navigate differential diagnosis - making an often daunting task for clinicians easier, quicker, and more accurate by using a concise outline format to list the most critical aspects of a disease entity. Uveitis: A Quick Guide to Essential Diagnosis opens with a Diagnosis Flowchart, so that the reader can select the most probable diagnoses based on patient's history and exam. From there the reader can then quickly turn to the corresponding chapter to learn about the most critical aspects of the disease entity: epidemiology, characteristic exam and imaging findings, prognostic factors, and treatment options. This book is written for ophthalmic care providers including general ophthalmologists, subspecialists, fellows, residents and optometrists and features research and contributions from institutions that are global leaders in uveitis care.

Contents:
Diagnosis Flowchart
Seronegative Spondyloarthropathies
Systemic Lupus Erythematosus
Scleroderma
Fuchs' Heterochromic Iridocyclitis
Sarcoidosis
Adamantiades-Behçet's Disease
Polyarteritis Nodosa --Granulomatosis with Polyangiitis
Relapsing Polychondritis
Pars Planitis
Multiple Sclerosis
Lens-Induced Uveitis
Tubulointerstitial Nephritis and Uveitis Syndrome
Birdshot Retinochoroidopathy
Sympathetic Ophthalmia
Vogt-Koyanagi-Harada Syndrome
Multifocal Choroiditis and Panuveitis
Multiple Evanescent White Dot Syndrome
Acute Posterior Multifocal Placoid Pigment Epitheliopathy
Acute Retinal Pigment Epithelitis
Serpiginous Choroidopathy
Subretinal Fibrosis and Uveitis Syndrome
Punctate Inner Choroidopathy
Acute Zonal Occult Outer Retinopathy
Syphilis
Lyme Disease
Bartonella
Tuberculosis
Leptospirosis
Brucellosis
Whipple's Disease
Rickettsial Diseases
Leprosy
Herpesviruses
Rift Valley Fever
Measles (Rubeola)
Rubella
Emergent Viral Infections
Presumed Ocular Histoplasmosis Syndrome
Candidiasis
Coccidioidomycosis
Cryptococcosis
Sporotrichosis
Pneumocytosis
Toxoplasmosis
Acanthamoeba
Giardia lamblia
Trypanosomiasis
Other Vector-borne Parasitic Infections
Toxocariasis
Ascariasis
Onchocerciasis
Loiasis
Cysticercosis
Diffuse Unilateral Subacute Neuroretinitis
Schistosomiasis
Ophthalmomyiasis
Ophthalmia Nodosa
HIV-associated Uveitis
Endophthalmitis
Vitreoretinal Lymphoma
Ocular Leukemia
Ocular Metastasis
Uveal Melanoma
Benign Lymphoid Hyperplasia of the Uvea
Juvenile Xanthogranuloma
Retinitis Pigmentosa
Intraocular Foreign Body
Drug-induced Uveitis
Uveitis During Pregnancy
Appendix I. Sun Nomenclature
Appendix II. Pharmacopeia.

Contents:
Chapter 1 Advances in ocular toxoplasmosis
Chapter 2 Viral anterior uveitis
Chapter 3 Behçet disease
Chapter 4 Biologicals in uveitis
Chapter 5 Corticosteroid in uveitis
Chapter 6 Glaucoma in uveitis
Chapter 7 Ocular lesions in AIDS
Chapter 8 imaging in uveitis
Chapter 9 Immunosuppressives inuveitis and ocular inflammation
Chapter 10 Intraocular lymphoma
Chapter11 Intermediate uveitis
Chapter 12 Management of inflammatory CNV.-Chapter 13 Ocular parasitic infections
Chapter 14 Ocular sarcoidosis
Chapter 15 Intraocular tuberculosis
Chapter 16 Paediatric uveitis
Chapter 17 Serpiginous choroiditis
Chapter 18 White dot syndromes.

Summary: Uveitis comprises a group of intraocular diseases that poses a diagnostic challenge to the ophthalmologists of all subspecialties, including uveitis specialists. The morphological expression of the diseases may be characteristic at times, but it is challenging to detect and recognize subtle clinical clues that might indicate towards a particular etiology: infectious, non-infectious or masquerade. Ancillary investigations including fluorescein angiography, indocyanine green angiography, auto fluorescence imaging, ultrasound, ultrasound biomicroscopy, laser flaremeter and optical coherence tomography play a crucial role in reaching a specific diagnosis and require proper interpretation in context of each disease variety. In addition, the radiological imaging, systemic work-up and laboratory investigations aid in establishing the diagnosis. This is a first comprehensive atlas that compiles these varied findings in each type of uveitis. It describes all uveitic entities employing the aid of slit lamp and anterior segment photographs, fundus photographs, ancillary investigations where applicable and relevant laboratory and radiologic investigations. The case-based format sets out the context clearly to match the diagnostic findings with the treatment plan. Covered in 136 chapters and more than 1000 images, this atlas is an essential reference guide for all uveitis specialists and general ophthalmologists. Regular updates on new insights, techniques and treatments meet the point-of-need requirements of the busy readers looking for most current information.

Contents:
Normal Non-inflamed Eye
Anterior segment slit lamp photography
Normal Fundus
Grades of Vitreous clarity
Normal Laser flaremeter
Normal fundus fluorescein angiography
Normal OCT of retina and choroid
Normal Autofluorescence of fundus
Normal ultrasound
Normal ultrasound biomicroscopy
Normal indocyanine green angiography
Normal Histology
Anterior Uveitis
Anterior granulomatous uveitis: Differential diagnosis
Anterior non-granulomatous uveitis: Differential diagnosis
Tuberculous
Leprosy
Syphilis
Leptospirosis
Cysticercosis
Lyme
Fungal endophthalmitis
Herpes
CMV
Rubella
HIV
The "Zebras"
Non infectious Anterior Uveitis
HLA B 27 spondyloarthritides
TINU
Fuchs uveitis
Behcets disease
JIA
Miscellaneous
Masquerade Syndrome
Lymphoma
Retinoblastoma
Leukemia
Metastasis
Xanthogranuloma
Posterior Uveitis
Differential diagnosis of infectious Retinitis
Differential diagnosis of infectious choroiditis
Bacterial endophthalmitis
Fungal Endophthalmitis
Candida retinochoroiditis
Aspergillus retinochoroiditis
Mucor retinochoroiditis
Coccidiomyccosis
Histoplasmosis
Presumed ocular histoplasmosis syndrome
Cryptococcus.