BookAxel S. Merseburger, Maximilian Burger, editors.
Summary: This comprehensive and timely textbook covers all aspects of the evidence-based management of genitourinary cancers and explains the fundamental principles underlying the available diagnostic and treatment approaches, including chemotherapy, radiotherapy, immunotherapy, and surgery. For each type of cancer – prostate, bladder, renal, testicular, and penile, plus rare urologic malignancies – clinical presentation, diagnosis, and treatment strategies are described in detail and information is provided on etiology, epidemiology, risk factors, and pathology, including TNM classification. Careful attention is also devoted to the complications that may be encountered when treating urologic malignancies and to the management of these complications. The text is complemented by the inclusion of numerous high-definition photographs and illustrations. Urologic Oncology will be a valuable reference and source of guidance for all oncologists, urologists and practitioners in related disciplines who treat patients with urologic cancers. -- Provided by publisher.
Contents:
Intro; Preface; Contents; About the Editors; Editorial Board; Contributors; Part I: Introduction; 1 Molecular Basics on Genitourinary Malignancies; Introduction; Prostate Cancer; Urothelial Carcinoma of the Bladder and Upper Urinary Tract; Kidney Cancer; Penile Cancer; Testicular Cancer; References; 2 Clinical Aspects and Investigations in Genitourinary Cancer; Principles of Common Radiological Investigations; X-Ray; Intravenous Urography (IVU); Ultrasound; Computed Tomography; Magnetic Resonance Imaging (MRI); Bone Scans; PET (Positron Emission Tomography) Scans; Renal Cell Carcinoma Clinical AspectsInvestigations; Laboratory; Imaging; Ultrasound; Appearance; Computed Tomography; MRI; Urothelial Cancer; Clinical Aspects; Presentation; Investigations; Laboratory; Imaging; CT Urography; Ultrasonography; MR Urography; Prostate Cancer; Clinical Aspects; Presentation; Investigations; Prostate-Specific Antigen (PSA); Other Biomarkers; Imaging; Ultrasound; MRI; CT Scan; Bone Scan; Positron Emission Tomography (PET); Testicular Cancer; Clinical Aspects; Presentation; Examination; Imaging; Ultrasonography; Tumor Markers; CT Scan; MRI and Bone Scan; PET; Penile Cancer Clinical AspectsPresentation; Premalignant Lesions; Invasive Cancer; Investigations; References; 3 Clinical Trials and Their Principles in Urologic Oncology; Introduction; Principles of Drug Development; Overview of Trial Designs; Types of Clinical Trials; Phases of Clinical Trials; Preclinical, Phase 1, and Phase 2 Trials; Phase 3 Trials; Phase 4 Trials and Post-Marketing Assessment; Design of Clinical Trials; Research Question and Hypothesis; The Patient Population; Definition of a Comparator; Calculating the Right Sample Size; Planning Statistical Analysis; Endpoints of Clinical Trials Primary and Secondary EndpointsComposite Variables and co-Primary Endpoints; Surrogate Endpoints (SEP); Patient-Reported Outcomes (PROs) and Endpoints and their Increasing Relevance in Clinical Trials; Adverse Event and Patient-Reported Outcomes (PROs) Reporting in Clinical Trials; Conducting the Trial in the Best Possible Way: How to Avoid Bias; Randomization; Blinding; Stratification; Clinical Trial Oversight; The Ethical Foundation of Clinical Trials; Principle of Equipoise; Ethical Considerations Within Clinical Trials in Urology Precision Medicine, Genomics, and Molecular Testing in Clinical TrialsThe Relevance of Genomic Research for Urological Cancers and for Clinical Trials in Uro-Oncology; Opportunities and Challenges in Cancer Genomic Research in Urological Tumors; Specific Considerations Related to Clinical Trials in Uro-Oncology; Medical Tumor Treatment; Caveats for Randomized Clinical Trials in Urologic Oncology Surgery; Measuring Outcome and Reporting in Uro-Oncology Trials; Final Considerations and Summary; Take-Home Messages; References; 4 Bone Target Therapy in Urologic Malignancies; Introduction