BookEric H. Bernicker, editor ; Amy C. Schefler, associate editor.
Summary: This book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases. Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.
Contents:
Molecular Basis of Uveal Melanoma and Emerging Therapeutic Targets
Clinical/Commercial
Genetic Testing in UM
BAP1 Tumor Predisposition Syndrome
Pathology of Uveal Melanoma
Epidemiology of Uveal Melanoma and Potential Clusters
Gene Expression Profiling in the Management of Uveal Melanoma
Surgical Considerations of Radiation Plaques and Enucleation
Uveal Melanoma: Imaging
Radiation Therapy in Ocular Melanoma
Late Complications of Radiation Therapy in Uveal Melanoma
Nanoparticles for the Treatment of Uveal Melanoma
Screening Schedules for Metastatic Disease
Adjuvant Therapy of Uveal Melanoma Liver-Directed Therapies for Hepatic Metastases
Systemic Therapy for Metastatic Uveal Melanoma
Cell Therapy for Uveal Melanoma.