BookYouhe Gao, editor.
Summary: This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".
Contents:
Urine is a better biomarker source than blood especially for kidney diseases
Urine reflection of changes in blood
Urimem facilitates kidney disease biomarker research
Human Urine proteome: a powerful source for clinical research
Exosomes in urine biomarker discovery
Urinary proteins with post-translational modifications
Applications of peptide retention time in proteomic data analysis
Urine Sample Preparation in 96-Well Filter Plates to characterize inflammatory and infectious diseases of the Urinary Tract
Variations of human urinary proteome
Evolution of the urinary proteome during human renal development and maturation
Hormone-dependent changes in female urinary proteome
Effects of exercise on the urinary proteome
Effects of Diuretics on Urinary Proteins
Applications of urinary proteomics in renal disease research using animal models
The application of urinary proteomics for the detection of biomarkers of kidney diseases
Dynamic changes of urinary proteins in focal segmental glomerulosclerosis model
Using isolated rat kidney to discover kidney origin biomarkers in urine
Comparing plasma and urinary proteomes to understand kidney function
Urinary Protein Biomarker Database: A Useful Tool for Biomarker Discovery.