Books

This book provides bibliographic information, ownership records, a detailed worldwide census and a description of the handwritten annotations for all the surviving copies of the 1543 and 1555 editions of Vesalius' 'De humani corporis fabrica'. It also offers a groundbreaking historical analysis of how the Fabrica traveled across the globe, and how readers studied, annotated and critiqued its contents from 1543 to 2017. This book sheds a fresh light on the book's vibrant reception history and documents how physicians, artists, theologians and collectors filled its pages with copious annotations. It also offers a novel interpretation of how an early anatomical textbook became one of the most coveted rare books for collectors in the 21st century.

This book creatively communicates the human and professional sides of the journey to the first ever near total face transplant, the response to this milestone in the medical community, and the effect it has had on the individuals involved. It focuses on the evolution of Professor Maria Siemionow as a microsurgeon and the processes by which she sensationally overcame the challenges her team encountered including the successful manipulation of the immune system to avoid rejection of the face tissue by the recipient. Face to Face: A Short History of Face Transplantation combines the medical and human elements of the development of face transplant surgery. It is not only targeted at the surgical professional and trainee, but also the general public who wish to read about the journey of how a significant medical advancement was made. It is also great reading to inspire girls of an age where they are thinking about career paths to believe they can do something extraordinary and could persuade some to pursue a career in an STEM subject.

This book brings together all the relevant available science behind face transplants. It is comprehensive in its coverage, encompassing patient and donor evaluation, ethics, legal issues, psychological issues, types of transplant, surgical technique, issues relating to immunosuppression, follow-up protocols, and current outcomes. Facial transplantation, which allows the replacement of missing anatomy with a perfect match based on transplant medicine principles, has become the most striking innovation in plastic surgery of the twenty-first century as surgeons and scientists progress from reconstructive surgery to restorative surgery. A robust team approach is, however, necessary to produce safe and efficient outcomes, and numerous questions are arising, from technical issues to ethical dilemmas. The reader will discover in this volume all the information required in order to understand this new discipline and to be able to set up a program of facial transplantation.

"The goal of this book is three-fold: - Optimal knowledge of facial anatomy is germane to obtaining the best results and safe outcomes in facial aesthetic surgery. This is especially the case with the intricate anatomy of the facial nerve in facelift surgery as discussed by Dr. James Stuzin. - Refine and define your knowledge on the vascular anatomy of the face to stay safe when performing facial fillers to prevent dreaded complications including blindness and skin loss, as discussed by Dr. Rod Rohrich. - Define the limitations and safety areas for the use of laser and minimally invasive technology from laser to Radiofrequency to ultrasound technology to optimize results and maximize safety in the face and neck areas as discussed by Dr. Erez Dayan and Dr. Vic Ross"-- Provided by publisher.

Accompanying DVD contains ... "27 video clips [which offer] an unmatched tutorial that takes you through the preparation and successful use of facial flaps in multiple facial regions."--Page 4 of cover.

The book offers a comprehensive approach to the assessment and treatment of disturbances in facial expression, oral movement, swallowing, breathing, voice and speech production caused by developmental and acquired neurological conditions. The principles outlined are used in patients with different etiologies (e.g. stroke, tumors, traumas). F.O.T. T., developed by Kay Coombes, is a hands-on approach based on an understanding of neurological functions and the way we learn from experience. The approach aims to give the patient experience of physiological posture and movement using facial-oral functions in normal activities of daily living (ADL). Rather than mere "exercises", F.O.T.T involves meaningful activities aiming to promote participation, according to ICF criteria. Four main areas are covered: nutrition, oral hygiene, nonverbal communication and speech. Each chapter summarises the problems of severely ill patients and shows the clinical reasoning behind the solutions offered. Separate chapters discuss tracheostomy management and the training of the carers involved, including relatives. The chapter authors are experienced specialists (physio-, occupational- and speech-language therapists and physicians), whose contributions aim to provide interdisciplinary perspectives and translate latest research into clinical practice.

This book offers a comprehensive overview of the surgical techniques available in reconstruction of the paralyzed face. It is divided into six parts. The first part introduces the topic of facial palsy, and the following parts provide detailed information on facial nerve reconstruction techniques, management of eye closure and smile reanimation. The book highlights symmetrization techniques and synkinesis and presents innovations and new frontiers in facial palsy. Written by an international group of experts who are committed to maintaining high standards and service in treating this condition and improving outcomes, it is a valuable source of information for clinicians and practitioners in plastic and reconstructive surgery, neurosurgeons and oral-and-maxillofacial surgeons, but also useful for researchers in this field.

Special considerations for Mohs patients / James Thornton and Jourdan Carboy -- Anesthesia for reconstruction of facial Mohs defects / Jayne Coleman and Javier Marul -- Mohs micrographic surgery / Sean Chen, Divya Srivastava, and Rajiv I. Nijhawan -- Cellular- and tissue-based wound care / James Thornton and Jourdan Carboy -- Full-thickness skin grafts / James Thornton and Jourdan Carboy -- Split-thickness skin grafting / James Thornton and Jourdan Carboy -- Cartilage grafts / James Thornton and Jourdan Carboy -- Pedicled flaps / James Thornton and Jourdan Carboy -- Local flaps / James Thornton and Jourdan Carboy -- Scalp reconstruction / James Thornton and Jourdan Carboy -- Forehead reconstruction / James Thornton and Jourdan Carboy -- Introduction to nose and simple nasal defects / James Thornton and Jourdan Carboy -- Complex nasal defects / James Thornton, Jourdan Carboy, and Nicholas T. Haddock -- Nasal reconstruction based on subunits / James Thornton and Jourdan Carboy -- Eyelid reconstruction / Ronald Mancini -- Cheek reconstruction / -- James Thornton and Jourdan Carboy -- Chin reconstruction / James Thornton and Jourdan Carboy -- Lip reconstruction / James Thornton and Jourdan Carboy -- Ear reconstruction / James Thornton, Jourdan Carboy, and Christopher Derderian -- Intraoperative complications and initial management / James Thornton and Jourdan Carboy -- Management of complications in the acute healing stage / James Thornton and Jourdan Carboy -- Management of complications in the late healing stage / James Thornton and Jourdan Carboy -- Skin graft revisions / James Thornton and Jourdan Carboy -- Local flap revisions / James Thornton and Jourdan Carboy -- Pedicled flap revisions / James Thornton and Jourdan Carboy.

"This landmark work covers the full range of aesthetic and reconstructive techniques in facial plastic surgery. Because of the coupling of aesthetics and function mandated by modern surgical standards, this book is organized by facial zone, rather than separated into aesthetic and reconstructive segments. The first six chapters highlight the basic principles of facial plastic and reconstructive surgery, including anatomy, proportions and beauty, visual documentation, and the principles of wound healing, aging, and flap design. Thereafter, sections are organized by facial zone or structure: the scalp and forehead, the eyelids and orbit, the nose, the ear, the bony facial skeleton, and the facial skin and soft tissue. Each section covers the range of aesthetic and reconstructive subjects relevant to the zone or structure in question. A separate section addresses conditions which affect multiple facial zones or tissues. The final section targets emerging trends and new directions in facial plastic and reconstructive surgery, designed to keep the reader both abreast of emerging technology, and intrigued and excited about the future possibilities for the specialty"--Provided by publisher.

"Facial Trauma Surgery: From Primary Repair to Reconstruction is the first comprehensive textbook of its kind on treating primary facial trauma and delayed reconstruction of both the soft tissues and craniofacial bony skeleton. This unique volume is a practical, complete reference for clinical presentation, fracture pattern, classification, and management of patients with traumatic facial injury, helping you provide the best possible outcomes for patients’ successful reintegration into work and society"--Publisher's description.

This book is a comprehensive guide to the use of injectable fillers for facial volumization. Traditionally, fillers have been used for anti-aging purposes such as for wrinkle treatments, but they are increasingly being applied in various ways to achieve beautification such as the augmentation of the nose, chin and lips, leveraging the volumizing effect of fillers. This trend is especially evident in Asian countries but can be expected to flourish elsewhere in the future. The book opens by explaining the specifics of pretreatment assessment and relevant aspects of the basic science of fillers. It then provides a detailed description of the anatomy, injection depth and injection amount relevant to each regional indication, easy to follow for even a novice injector, based on a rich assortment of anatomical illustrations, ultrasound imaging and cadaveric photos provided to assist their understanding. And guidance is also provided on combination treatments in conjunction with botulinum toxin, thread lifting, fat-dissolving injection, etc. Potential complications and countermeasures specific to volumization with fillers are identified. The book features a wealth of illustrations showing the relevant anatomy and before and after appearances, as well as video clips for each indication. Written by a specialist with extensive experience, it provides safe and effective guidance for both beginners and advanced practitioners.

Guidelines for Book Users: Instructors, Supervisors, and Students -- Overview of Genetic Counseling: History of the Profession and the Reciprocal Model of Practice -- Listening to Patients: Attending Skills -- Listening to Patients: Primary Empathy Skills -- Gathering Information: Asking Questions -- Structuring Genetic Counseling Sessions: Initiating, Contracting, Ending, and Referral -- Collaborating with Patients: Providing Information and Facilitating Patient Decision Making -- Responding to Patient Cues: Advanced Empathy and Confrontation Skills -- Patient Factors: Resistance, Coping, Affect, and Styles -- Providing Guidance: Advice and Influencing Skills -- Counselor Self-Reference: Self-Disclosure and Self-Involving Skills -- Genetic Counseling Dynamics: Transference, Countertransference, Distress, Burnout, and Compassion Fatigue -- Professionalism: Ethically-Based Reflective Practice -- Appendix A: ACGC (2015) Practice-Based Competencies -- Appendix B: NSGC Code of Ethics (2017).

Facilitating treatment adherence in pain medicine : adherence--the great confounder! / Martin D. Cheatle and Perry G. Fine -- Treatment adherence in chronic pain : predictors, models, and a role for psychological flexibility / Anthony M. Harrison, Christopher Graham, and Lance M. McCracken -- Adherence In pharmacotherapy : maximizing benefit and minimizing risk / Marc O. Martel and Robert N. Jamison -- The use of drug testing in promoting treatment adherence in pain medicine / Howard A. Heit and Douglas L. Gourlay -- Adherence to weight loss and physical activity / E. Amy Janke and David E. Goodrich -- Biopsychosocial approach to improving treatment adherence in chronic pain / Martin D. Cheatle and Lara Dhingra -- Adherence in pain medicine : ethical considerations / Michael E. Schatman and Oscar J. Benitez.

Emotional distress, difficulty concentrating and focusing on academic work, mood changes, excessive substance use, self-harming behaviors--when it comes to campus sexual assault and intimate partner violence, the consequences are numerous and serious. This new volume leverages the wisdom of psychiatry, college mental health, and higher education to develop a holistic approach to addressing sexual and relationship violence on campuses.

Ribonucleic acids (RNA) are one of life's fundamental biopolymers with the capacity to store genetic information, perform catalysis, and alter their structures and behavior in response to environmental stimuli and have been found central to critical biological processes ranging from protein translation to gene regulation. Measuring the quantities and structures of these molecules is therefore an important gateway to understanding the mechanisms that govern cell behavior. Many of the current high-throughput methodologies used to interrogate the properties of RNA molecules come in the form of ensemble average measurements: weighted projections of the multiple biological or physical states of the RNAs being probed. Inferring the properties of and/or relationships between these "hidden" states from ensemble averages gives important insights into the mechanisms and functions of RNAs in several scenarios. For example, ensemble average measurements of the structural properties of an RNA sequence in solution gives a weighted projection of the properties of all the structures that the molecules adopt in equilibrium, many of which may be functionally relevant. In another scenario we might be interested in measuring the expression levels of several genes in a pool of cells through mRNA quantification: the resulting ensemble averages will be a projection of the transcriptional programs of the cells in multiple biological states. In this dissertation, I develop methods to factorize and summarize state-wise properties of these ensemble averages. First, I present methods to infer properties of the secondary structure ensembles of RNAs using classic and readily obtainable chemical mapping measurements. To this end, I interrogate statistical relationships between structural properties and chemical mapping measurements by creating and mining the RNA Mapping Database (RMDB), the most diverse repository of RNA structural data to date; by developing the RNA Ensemble Extraction From Footprinting Insights Technique (REEFFIT), a secondary structure landscape modeling framework that uses perturbed, multi-dimensional chemical mapping data; and by developing chemical mapping data statistics for characterizing the entropy of an RNA's structural ensemble. These methods help reveal the rich folding landscapes of non-coding RNAs, reconcile two models for the structures of the human accelerated region 1A (HAR1A) chimp and human genes, and establish the properties of the structural landscapes of random RNA sequences that serve as a useful "biological null" when characterizing novel and putatively-functional RNAs. In the second part of this dissertation I focus on examining ensemble averages of gene expression measurements by developing the Community LASSO with Intersecting Priors (CLIP), a method to jointly infer gene co-expression relationships and gene communities from gene expression values under multi-factorial perturbation schemes; and by introducing the notion of "gene roles" defined by their network and community topologies. I use CLIP and gene roles to build a transcriptional map of human heart failure using more than 300 failing and healthy human left-ventricular heart samples and pinpoint central genes and networks that appear to be involved in this devastating condition. One of these central genes, the regulatory subunit of protein phosphatase I PPP1R3A, seems to play different gene roles under healthy and pathological conditions. I validate these inferences using whole-transcriptome timed "snapshots" of an in vitro model of hypertrophy, verifying significant cross-gene expression time dependencies in half of the gene communities inferred by CLIP, demonstrating that PPP1R3A ameliorates hypertrophy in vitro, and suggesting causal routes that this gene may take to alter hypertrophy and heart failure phenotypes.

One of the American Medical Association's core strategic objectives is to advance health care delivery and payment models that enable high-quality, affordable care and restore and preserve physician satisfaction. Such changes could yield a more sustainable and effective health care system with highly motivated physicians. To that end, the AMA asked RAND Health to characterize the factors that lead to physician satisfaction. RAND sought to identify high-priority determinants of professional satisfaction that can be targeted within a variety of practice types, especially as smaller and independent practices are purchased by or become affiliated with hospitals and larger delivery systems. Researchers gathered data from 30 physician practices in six states, using a combination of surveys and semistructured interviews. This report presents the results of the subsequent analysis, addressing such areas as physicians' perceptions of the quality of care, use of electronic health records, autonomy, practice leadership, and work quantity and pace. Among other things, the researchers found that physicians who perceived themselves or their practices as providing high-quality care reported better professional satisfaction. Physicians, especially those in primary care, were frustrated when demands for greater quantity of care limited the time they could spend with each patient, detracting from the quality of care in some cases. Electronic health records were a source of both promise and frustration, with major concerns about interoperability between systems and with the amount of physician time involved in data entry.

Rotator cuff surgery is currently the most common surgical procedure involving the shoulder. Unfortunately despite major technical advances, there is still a significant rate of failure of primary rotator cuff repair, ranging from 10% to 40%. This book describes the diagnosis, classification, assessment, and management of failed rotator cuff repairs. It also explores the etiology of the failed repairs, presents a series of treatment options, and discusses the complications. In a multidisciplinary format it addresses both how to prevent failure and how to diagnose and manage the failed rotator cuff, including imaging, laboratory testing, nutrition, surgery and rehabilitation. This comprehensive book, published in collaboration with ISAKOS, appeals to all stakeholders in orthopedic medicine and surgery.

This book provides an up-to-date and comprehensive overview of the etiology, diagnosis, and treatment of conditions affecting the structure and function of the right heart, comprising the right atrium, right ventricle, tricuspid valve, and pulmonary circulation. The right ventricle works against a reduced afterload as compared to the left ventricle, and the clinical picture of heart failure is generally dominated by the symptoms of left heart failure and hence initially neglected until they evolve into overt right heart failure with splanchnic congestion. When picked up at the very late stage, medical management and mechanical support of right heart failure are considered ineffective, and heart transplantation offers the only treatment option. The Failing Right Heart will be an essential reference for cardiac surgeons, cardiologists, cardiac anesthesiologists and cardiac intensivists on the diagnosis and treatment of patients with congenital or acquired right heart disease. The book deals with anatomy and physiology of the right heart, the etiology and the role of imaging of right heart failure, as well as the treatment options, from pharmacological regimes to surgery. Algorithms and flow diagrams are included to provide the reader with illustrated snapshots of the decisions involved in the management of these patients.

A multi-authored book, with editors and authors who are leaders in Faith Community Nursing (FCN) that aims to address contemporary issues in faith-based, whole person, community based health offering cost effective, accessible, patient centered care along the patient continuum while challenging contemporary health policy to include more health promotion services. Twenty-five chapters take the reader from a foundational understanding of this historic grass-roots movement to the present day international specialty nursing practice. The book is structured into five sections that describe both the historical advancement of the Faith Community Nursing, its current implications and future challenges, taking into account the perspectives of the pastor, congregation, nurse, health care system and public health national and international organizations. The benefits of this book are that it is intended for a mixed audience including lay, academic, medical professionals or health care executives. By changing the mindset of the reader to see the nurse as more than providing illness care, the faith community as more than a place one goes to on Sunday and health as more than physical, creative alternatives for promoting health emerge through Faith Community Nursing.

This book provides practical tools for fall prevention in cognitively impaired older adults. The text presents a comprehensive and state-of-the-art update that covers the pathophysiology, epidemiology, and clinical presentation of the event, which affects up to 60 percent of aging patients with cognitive impairment. Written by transdisciplinary experts in experts in geriatric medicine, rehabilitation, neurology, and physiotherapy, the text presents practical, evidence-based guidelines for the assessment, approach, and treatment of these patients and includes illustrations and resources for quick reference. Falls and Cognition in Older Persons is a unique contribution to the literature serving geriatricians, family medicine physicians, emergency medicine physicians, neurologists, rehabilitation and physiotherapy specialists, geriatric nurses, and those interested in public health.

This book, written by very well known opinion leaders in the field, covers all aspects of familial Mediterranean fever, the most common monogenic autoinflammatory disease. The opening chapters explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies. A large part of the book is then devoted to a detailed description of the typical and atypical clinical presentations, the disease course, and potential complications in both pediatric and adult patients. Guidance is provided on the measurement of disease severity and the management of patients in daily practice. The advice regarding treatment is based on the best currently available evidence and attention is also paid to important emerging treatments. The book is part of Springer's series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Monogenic autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Familial Mediterranean fever itself is due to a mutation in the MEFV gene, which codes for the protein pyrin; it is characterized by periodic fever and episodes of painful inflammation in the abdomen, chest, and joints. Familial Mediterranean Fever will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with the disease.

This text is one of the first comprehensive resources on understanding and working with families in the intensive care unit. The text provides a conceptual overview of the Family ICU Syndrome, a constellation of physical morbidity, psychopathology, cognitive deficits, and conflict. Outlining its mechanisms, the book presents a guide to combating the syndrome with an interdisciplinary team. The text represents the full array of the interdisciplinary team by also spotlighting administrative considerations for health care management and approaches to training different members of the health care team. Family voices are featured prominently in the text as well. The book also addresses the complete trajectory of needs of care, including survivorship and end-of-life care. Written by experts in the field, Families in the Intensive Care Unit: A Guide to Understanding, Engaging and Supporting at the Bedside is a state-of-the-art reference for all clinicians who work with families in the ICU.

The most effective treatments for child and adolescent psychopathology are often family-based, emphasising the active involvement of family members beyond the referred individual. This book details the clinical skills, knowledge, and attitudes that form the core competencies for the delivery of evidence-based family interventions for a range of mental health problems. Offering practical case studies to illustrate treatment principles, and discussing barriers to treatment and problem-solving in relation to common difficulties. Covers topics such as anxiety, attention-deficit hyperactivity disorder, sleep, and eating disorders. Therapist competencies are thoroughly examined, from the role they play in severe/complex cases and in achieving successful outcomes to commonly misunderstood aspects of family-based interventions and how they can be enhanced. Clinical approaches to working with diverse families, and those of children affected by parental psychopathology, child maltreatment and family violence are also explored. Essential reading for psychologists, psychiatrists, paediatricians, mental health nurses, counsellors and social workers.

"This book describes the theoretical and clinical rationale for the use of family-based treatment (FBT) for Avoidant Restrictive Food Intake Disorder (ARFID). Based on years of clinical care and systematic study of children and adolescents with ARFID using Family-based Treatment for Avoidant/Restrictive Food Intake Disorder (FBT-ARFID), the manual provides guidance about assessment of ARFID. Topics covered include how to incorporate the medical, nutritional, and psychiatric problems that are common with this disorder and how to evaluate the principle maintaining behaviors related to lack of interest or appetite, extreme sensory sensitivities to food, and fear of physical repercussions of eating (e.g. pain, vomiting, allergic reactions). Step by step illustrations of the key interventions in FBT-ARFID are provided and detailed case discussions demonstrate how these are implemented in a range of cases. Ideal for clinical practitioners who treat children and adolescents with eating disorders, specifically, psychologists, psychiatrists, social workers, and allied health practitioners"-- Provided by publisher.

"This dynamic plan will help the whole family kick-start their health and wellness and set the stage for long-term, lasting improvements in nutrition, fitness, sleep, stress, and screen use habits. Dr. Natalie Digate Muth walks families through this thirty-day transformation that establishes a baseline and goals, creates routines and healthy habits, and provides strategies for overcoming frustration and recognizing obstacles. At the end of thirty days, parents and children will have laid the ground work to continue a lifetime of healthy habits. The plan also includes family-friendly recipes, health and fitness experiments for the kids, and additional wellness tools." -- back cover.

"The closest you can get to the Family Medicine clerkship shelf exam without actually taking it Family Medicine: PreTest Self-Assessment & Review, Fourth Edition is the perfect way to assess your knowledge of Family Medicine for the USMLE Step 2 CK and clerkship shelf exam. You'll find approximately 500 USMLE-style questions and answers that target the clerkship's core competencies, along with detailed explanations of both correct and incorrect answers. All questions have been reviewed by students who recently passed the boards and completed their clerkship to ensure they match the style and difficulty level of the exam, so you know you are studying the most relevant, high-yield material possible. Approximately 500 USMLE-style questions, just like you will see on the exam. Detailed explanations for right and wrong answers, that zero-in on must-know information. Targets what you really need to know for exam success. Thoroughly reviewed by students who aced their clerkship"-- Provided by publisher. "Family Medicine: PreTest gives you hundreds of review questions and answers, along with high yield rationale to prepare you for your clerkship shelf exam, as well as the USMLE Step 2. Both the scope of content, as well as the format of the questions, parallels what you will see on your actual exams"-- Provided by publisher.

This book is organized into short, focused chapters almost exclusively dedicated to topics relevant to daily practice. All lead authors are themselves accomplished family physicians who can specifically address the needs, concerns, and interests of this crucial profession. As one of the key reference textbooks for family medicine, it is very important to provide the most up-to-date knowledge to support learners and practitioners of family medicine in the face of rapidly expanding clinical knowledge and the extensive self-examination of family medicine. Family Medicine: Principles and Practice, 8th Edition, is a must-have reference for medical students, residents, practicing physicians, nurse practitioners and physician assistants with an active role in patient care.

"The purpose of this book is to help clinicians and students better understand how to diagnose and manage typical (and some atypical) patient cases. While the focus is on the Nurse Practitioner role, this book will be useful to other patient care providers, such as physicians and physician's assistants. The contributing authors have worked hard to update cases from the first edition of the book to better reflect patient-centered language and advances in care. We have developed several new cases, such as one on climate change, to assist clinicians with scenarios that were not as predominant as they are today. We have presented a variety of patients in these cases with regard to age, gender preference, socioeconomic status, family status and other considerations. However, please don't hesitate to alter these demographics to tailor the cases for your specific needs"-- Provided by publisher.

"If you are studying for the family nurse practitioner certification exam, Maria T. Codina Leik's highly acclaimed Family Nurse Practitioner Certification Intensive Review is a must-have resource, and with interactive digital prep included with purchase, it is easier than ever to study for the FNP exam. Lauded for its concise, well-organized format, this fourth edition has been significantly revised and updated to feature key information about the new AANPCB and ANCC certification exams, all new end-of-chapter review questions, and new full-color images. Leik's Family Nurse Practitioner Certification Intensive Review, fourth edition also features four practice tests with hundreds of new questions and rationales -- 800 questions in total. Extensive test-taking techniques and question dissection and analysis chapters help you identify the best clues during the problem-solving process so that you can strategically master the certification exam. Designed to help FNP candidates boost their confidence through intensive review and high-quality questions, the fourth edition continues to provide succinct, precisely targeted “need-to-know” details of diseases and classic presentations you can expect to see in practice in patients across the life span. Organized by body system, chapters are consistently formatted to include Danger Signals, Normal Findings, Lab Findings, Benign Variants, and Disease Review topics. Each chapter features valuable Exam Tips and Clinical Pearls that highlight key considerations and information likely to be encountered on the exam, ideal for a last-minute refresher before test day. Ensure success by making this essential family nurse practitioner resource -- praised by thousands for helping them pass their certification -- a key part of your exam prep study regimen. Note to readers: The new ExamPrepConnect Fourth Edition online course will launch March 2021. In the interim, your book purchase includes access to the current ExamPrepConnect Third Edition online course. Your 6-month digital subscription to the Fourth Edition will begin as soon as that course is live, and we will notify you by email."--Publisher's description.

The life and death, but also the creative work of famous musicians is closely linked to their personal medical histories. In "Famous Composers Diseases Reloaded" these case histories are vividly reconstructed on the basis of authentic biographical testimonies and closely linked to the personalities of the musicians. The latest research findings on the pathophysiology of these composers will be woven into the overall picture. Was Paganini's "devilishness" caused by a hereditary disease? Did Scarlatti have strange signs of illness on his fingers? What did Bach really die of? How did "Christel" from a dubious milieu change Schumann's entire life? What aggravated Ravel's underlying illness so that he did not complete a single composition in the last five years before his death? How did Tarrega manage to play the guitar again after his stroke with hemiplegia? Did the Brazilian Villa-Lobos' worldwide reputation help him live longer thanks to the best treatment available to him? Andreas Otte, physician and musician, has incorporated the latest medical history research into the composers' pathographies. This book is an exciting and "well-tempered" reading experience not only for physicians, music lovers, musicologists and musicians, but for all readers who want to develop a basic understanding of the pathophysiology and life scores of these great masters under current conditions from today's perspective.

Growth of neonatal perinatal medicine: a historical perspective -- Epidemiology for neonatologists -- Medical ethics in neonatal care -- Legal issues in neonatal-perinatal medicine -- Evaluating and improving the quality and safety of neonatal intensive care -- Simulation and debriefing in neonatal-perinatal medicine -- Practicing evidence-based neonatal-perinatal medicine -- Perinatal and neonatal care in developing countries -- Social and economic contributors to neonatal outcome in the united states -- Genetic aspects of perinatal disease and prenatal diagnosis -- Perinatal ultrasound -- Estimation of fetal well-being -- Surgical treatment of the fetus -- Adverse exposures to the fetus and neonate -- Intrauterine growth restriction -- Developmental origins of adult health and disease -- Hypertensive disorders of pregnancy -- Pregnancy complicated by diabetes mellitus -- Obstetric management of prematurity -- Fetal effects of autoimmune disease -- Obstetric management of multiple gestation and birth -- Post-term pregnancy -- Immune and nonimmune hydrops fetalis -- Amniotic fluid volume -- Perinatal infections and chorioamnionitis -- Placental pathology -- Anesthesia for labor and delivery -- Physical examination of the newborn -- Birth injuries -- Congenital anomalies -- Overview and initial management of delivery room resuscitation -- Role of positive pressure ventilation in neonatal resuscitation -- Oxygen therapy in neonatal resuscitation -- Chest compression, medications, and special problems in neonatal resuscitation -- Thermal environment of the intensive care nursery -- Optimization of the NICU environment -- Biomedical engineering aspects of neonatal cardiorespiratory monitoring -- Diagnostic imaging of the neonate -- Anesthesia in the neonate -- The late preterm infant -- Nutrient requirements/nutritional support in premature neonate -- Support for the family -- Principles of drug use in the fetus and neonate -- Principles of drug use during lactation -- Pharmacokinetics in neonatal medicine -- Infants of substance-using mothers -- Developmental immunology -- Postnatal bacterial infections -- Fungal and protozoal infections of the neonate -- Viral infections in the neonate -- Normal and abnormal brain development -- White matter damage and encephalopathy of prematurity -- Intracranial hemorrhage and vascular lesions in the neonate -- Hypoxic–ischemic encephalopathy -- Seizures in neonates -- Hypotonia and neuromuscular disease in the neonate -- Intracranial and calvarial disorders -- Spinal dysraphisms -- Hearing loss in the newborn infant -- Early childhood neurodevelopmental outcomes of high-risk neonates -- The role of neonatal neuroimaging in predicting neurodevelopmental outcomes of preterm neonates -- Lung development and maturation -- Assessment of neonatal pulmonary function -- Respiratory distress syndrome in the neonate -- Assisted ventilation of the neonate and its complications -- Neonatal respiratory disorders -- Neonatal apnea and the foundation of respiratory control -- Upper airway lesions in the neonate -- Bronchopulmonary dysplasia in the neonate -- Therapy for cardiorespiratory failure in the neonate -- Cardiac embryology -- Pulmonary vascular development -- Prenatal diagnosis of congenital heart disease -- Patent ductus arteriosus -- Congenital defects of the cardiovascular system -- Cardiovascular problems of the neonate -- Disorders of cardiac rhythm and conduction in newborns -- Neonatal management of congenital heart disease -- Hematologic and oncologic problems in the fetus and neonate -- Blood component therapy for the neonate -- Development of the neonatal gastrointestinal tract -- Gastrointestinal reflux and motility in the neonate -- Disorders of digestion in the neonate -- Selected gastrointestinal anomalies in the neonate -- Neonatal necrotizing enterocolitis -- Disorders of carbohydrate metabolism in the neonate -- Disorders of calcium, phosphorus, and magnesium metabolism in the neonate -- Thyroid disorders in the neonate -- Disorders of sex development -- Inborn errors of metabolism -- Neonatal jaundice and liver diseases -- Fluid, electrolytes, and acid-base homeostasis -- The kidney and urinary tract of the neonate -- The skin of the neonate -- Examination and common problems in the neonatal eye -- Retinopathy of prematurity -- Musculoskeletal disorders in neonates -- Bone and joint infections in neonates -- Congenital abnormalities of the upper and lower extremities and spine -- Therapeutic agents -- Tables of normal values -- Schedule for immunization of preterm infants.

The story of "Jewish prisoner-scientists in Buchenwald who made a vaccine against ... typhus. Their untold secret: they provided the real vaccine to camp inmates but a fake one to German troops at the eastern front"--Dust jacket back. Describes the true story of how the eccentric Polish scientist tasked by the Nazis to create a typhus vaccine hid the intelligentsia from the Gestapo by hiring them to work in his laboratory.

'This book deals with the sustainability of agriculture on the Black Earth by drawing on data from long-term field experiments. It emphasises the opportunities for greater food and water security at local and regional levels. The Black Earth, Chernozem in Russian, is the best arable soil in the world and the breadbasket of Europe and North America. It was the focus of scientific study at the very beginnings of soil science in the late 19th century-as a world in itself, created by the roots of the steppe grasses building a water-stable granular structure that holds plentiful water, allows rapid infiltration of rain and snow melt, and free drainage of any surplus. Under the onslaught of industrial farming, Chernozem have undergone profound but largely unnoticed changes with far-reaching consequences-to the point that agriculture on Chernozem is no longer sustainable. The effects of agricultural practices on global warming, the diversion of rainfall away from replenishment of water resources to destructive runoff, and the pollution of streams and groundwater are all pressing issues. Sustainability absolutely requires that these consequences be arrested.

This book provides an up-to-date review of fasciolosis, a disease caused by Fasciola hepatica and Fasciola gigantica, including its biology, transmission, epidemiology, host distribution, economic impact, and novel approaches for its diagnosis, treatment and prevention. It first offers a brief overview of the history of the disease, the genetic diversity of the parasite and its distribution, and the ecology of the vector snail, which belongs to the Lymnaeidae/Planorbidae family. It also examines the current strategies and novel approaches for controlling the parasite, diagnosing infections and vaccine development. Importantly, it highlights issues relating to the control of fasciolosis, including drug resistance, lack of effective diagnostics, and the parasites long-term survival strategies based on regulation and modulation of the host immune system. Lastly, it discusses the novel control snail vectors using bait formulations, and synergetic and phototherapy treatment with chlorophyllin, which does not kill the vector.

Radiology is a powerful tool to detect and diagnose abnormalities by allowing doctors to visually inspect internal pathology that could not otherwise be seen. However, assessing radiological images is limited by variations among practitioners, including deficiencies in their reporting of these imaging examinations as well as in their interpretations. Three main sources of these variations in interpretation are incorrectness of observations in the images, incompleteness of the radiological observations reported to characterize the abnormalities, and inconsistency of these observations with respect to the radiologists' overall impression. I hypothesized that delivering decision support during reporting time to improve completeness and correctness of reports would improve consistency, and therefore, diagnostic performance To test this hypothesis, I formulated a decision support framework that provides feedback to radiologists during the reporting of their radiological observations. I developed this system by creating novel statistical models to link radiological observations, computational imaging features, and disease to recognize incorrectness, incompleteness and inconsistency in reporting. I then harnessed these models to create a quantifiable metric of observation quality. In this dissertation, I describe this system with the following specific aims: (1) developed methods to assess completeness and correctness of radiology reports, (2) evaluated these methods in two important radiological domains (mammography and liver CT), and (3) developed framework to provide feedback to radiologist to ensure consistency between report and diagnosis, improving diagnostic performance. I performed three major experiments to verify these aims. In my first project, I developed an image annotation classifier that predicts the descriptors a radiologist would use in a report to describe a liver lesion on a CT scan. I predicted 30 different types of descriptors and had a mean AUC of 0.816 ± 0.141 with a misclassification rate of 0.1443 ± 0.0881. These results showed that the image annotation framework could be used as a second reader for radiological reports. In my next project, I developed a novel metric to measure whether reports had enough information to justify the radiologist's diagnosis. I found that this measure could accurately predict when radiologists make errors based solely on the evidence they give to justify their diagnosis, with 82.6% classification accuracy. Finally, I created a framework to deliver feedback to the radiologist in order to complete their report in the most efficient manner. I found that using the aforementioned incompleteness score coupled with a myopic, mutual information descriptor selection criteria allows a decision support system to achieve 93.6% diagnostic classification accuracy with an average of 4 observations. This achieves better classification accuracy than the decision support system that uses all 20 descriptors by 1.5%. The results from these three experiments showed that it is feasible to deliver decision support to improve reports, and that improving reports improves diagnostic performance.

This volume presents a comprehensive collection of quick assays for the detection of nuclear and mitochondrial DNA damage and its effects in live and fixed cells and tissues, and in bacterial genomes. Although, such rapid techniques are in demand in the "research trenches" they are not covered well in the literature. This volume is the first such compendium of the time-saving techniques for detection of DNA damage and its direct physiological outcomes including apoptosis, necrosis and phagocytic clearance. The volume demonstrates all levels of detection, starting from the molecular level up to the level of the entire live organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Fast Detection of DNA Damage: Methods and Protocols aims to provide easily reproducible techniques requiring only few steps to perform.

"I wrote this book to provide nurses from all practice settings and experience levels the knowledge and understanding of how to care for the LGBTQ population. The first of its kind, this book offers the nurse concise and pragmatic information to deliver culturally competent and inclusive care. Lesbian, gay, bisexual, transgender, queer, and other gender minorities (LGBTQ) face unique challenges and barriers to accessing healthcare, resulting in poor health outcomes. Studies have consistently shown the greater risk for poor health outcomes due to fear or mistrust of healthcare providers, such as nurses, because of past discrimination and refusal of care and acceptance, which have created systemic health disparities. Nursing textbooks and education predominantly focus on cisgender heteronormative populations - leaving the nurse without the knowledge and information needed to care for this diverse population"-- Provided by publisher.

"This book is an overview about how cannabinoids can play an integral part in a patient's pain management treatment plan. It is a resource for anyone working with patients experiencing chronic non-cancer related pain, including physician assistants, nurse practitioners, clinical nurse specialists, and bedside nurses"-- Provided by publisher.

Introduction to evidence-based practice -- Asking the compelling question -- The Iowa method of EBP to promote quality care -- A basic understanding of research -- Quantitative research -- Qualitative research -- Finding the evidence -- Evaluating the evidence -- Barriers to disseminating the evidence -- EBP in the nurse residency program -- Examples of a PICO/T process.

"This book is designed for a new graduate or recent graduate transitioning into the critical care environment. Designed as a quick reference of the most common admitting diagnoses in critical care including causes, signs and symptoms and interventions, this text will be used every day"-- Provided by publisher.

Pediatrics -- Internal medicine -- Obstetrics and gynecology -- Psychiatry -- Surgery/emergency care -- Geriatrics -- General facts.

""Wounds" - What a broad term! The Original Roget's International Thesaurus gives all of the following terms for "wounds": trauma, injury, hurt, lesion, cut, incision, scratch, gash, puncture, stab, laceration, mutilation, abrasion, gangrene, necrosis, and more. If Roget were a healthcare provider looking at a wound for the first time, he would not stop with just a simple surface term. In a split second, he would send all that information to his mental search engine for processing. His simple surface term, abrasion, would generate more sensory input such as: classifications - common, complex, or atypical, chronic, or acute, and bioburden - clean, dirty, infected, and so on. Before heaving a big sigh, he might have contemplated nutrition and pain management. After all this was sufficiently processed, another broad concept would surface. "I need a remedy." Roget's brain interface system would go into overdrive, bouncing from one neuron to neuron as more definitions came to mind, such as : relief, help, restorative, medicine, drug, soothing, debridement, salve, antibiotics, poultices, bandage, healing, curative, restorative, palliative, protective...oh, and coming up for air...preventive. Whew!"-- Provided by publisher.

"This book begins with a description of what is data and why it is important. The chapters explain how you can influence the quality of data and gain an understanding to advocate for the effective capture and use of data to improve your knowledge and provide the best patient care possible. The book will help you understand how you can influence the effective use of technology in healthcare delivery"-- Provided by publisher.

This pocket-sized, quick-access guide gives nurses crucial information they need to understand, identify, and effectively counter incivility, bullying, and violence in all nursing settings. Viewing nurse bullying as an institutional problem, this text expounds upon the American Nurses Association (ANA) position statement "Incivility, Bullying, and Workplace Violence" and includes definitions and statistics about nurse bullying and guidance on what nurses at any level can do when faced with a bully. Delivered in an easy-to-read, bulleted format, this resource covers all aspects of the problem, explores why nurses bully each other, and discusses and quantifies the cost and impact of bullying on individuals, the workplace, and the broader health care system. Four institutional case study chapters delineate the different forms bullying can take and provide advice on how to handle them, and a "bully-proofing" chapter offers such useful tools as a bullying checklist and a guide to "de-toxifying" the workplace, as well as an explanation of the ANA Code of Ethics as it relates to bullying. Key Features: Addresses all facets of nurse bullying, from origins and manifestations to evidence-based interventions and prevention strategies; Based on the hallmark ANA document "Incivility, Bullying, and Workplace Violence"; Contains 10 instructive case studies depicting common bullying scenarios; Proivdes a wealth of anti-bullying resources for use in all nursing settings. -- from back cover.

"The perception of an inadequate body shape is a cause of concern to many people, and new techniques for altering body shape are increasingly being developed and offered to patients. Of these, the removal and transfer of fat is fast growing in importance and availability. This practical guide offers a comprehensive overview of this rapidly-evolving field, and thorough coverage of the implementation of fat removal techniques, both invasive and non-invasive, in a cosmetic practice. It begins with an overview of basic fat anatomy and physiology as an important introduction to this topic. The distinction between the physiology and treatment of cellulite and fat is also discussed. The next section of the book covers invasive treatments of fat such as traditional liposuction, laser-assisted liposuction, fat transfer procedures and mesotherapy. The latter half of the book largely focuses on non-invasive treatments for fat, including radiofrequency, ultrasound, cooling and laser technologies for fat removal. Throughout, potential complications and pitfalls of the various treatments are discussed. Edited by Matthew Avram, with contributions from a group of clinical stars, this book will appeal to cosmetic dermatologists, plastic surgeons, aesthetic medical practitioners, and obstetricians/gynaecologists"--Provided by publisher.

Chronicles the story of the early 1900s typhoid fever epidemic in New York, providing details as to how its infamous carrier was ultimately tracked down and stopped.-- (Source of description not identified)

This volume offers detailed information on the behaviour of various water pollutants, and on the principles and concepts of groundwater flow and transport. It will help readers to understand and execute the planning, supervision, and review of solute transport and groundwater modeling projects. The book also discusses the role and fate of elements that have been identified as major contaminants in surface and subsurface waters, and their adverse effects on ecology and human health. The book explores this theme throughout four sections - a. Understanding Soil-Water Systems, b. Fate and Transport of Pollutants, c. Physico-Chemical Treatment of Wastewater and d. Microbial Techniques Used to Decontaminate Soil-Water Systems. Introducing readers to a range of recent advances concerning the fundamentals of subsurface water treatment, it offers a valuable guide for teachers, researchers, policymakers, and undergraduate and graduate students of hydrology, environmental microbiology, biotechnology and the environmental sciences. It also provides field engineers and industrial practitioners with essential support in the effective remediation and management of polluted sites.

In this soon-to-be gold-standard text, a distinguished panel of experts provides a comprehensive discussion of the various medical, neurological, psychiatric, and psychological factors underlying fatigue and sleepiness in the workplace and in patients. In reviewing current best practices in managing fatigue and sleepiness conditions to improve workplace safety, the book importantly begins with an overview of fatigue's definitions and concepts. It then moves into discussing the historical perspective on sleepiness and fatigue, the definitions and classifications of fatigue, and assessments of fatigue in the laboratory and in clinical settings. The book continues by exploring medical causes of fatigue in detail; how medication and recreational agents may result in fatigue; and the treatment of sleep disorders. Additional topics include best practices in the treatment of narcolepsy and hypersomnia, a review of circadian rhythm and fatigue, the treatment of heart failure and improvement in fatigue, and the management of fatigue in hospitalized patients. A major contribution to the field, this invaluable title will be of significant interest to all clinicians concerned with safeguarding safety in the workplace by accurately diagnosing and managing patients with fatigue and sleepiness problems. Researchers will also find this title of great interest.

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation, and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products, and nasal and inhalation products. FDA Bioequivalence Standards is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies, and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards.

"This book explains the Food and Drug Administration (FDA) as an institution and provides understanding of its nomenclature, societal role, policies, goals and challenges. While many readers will have some knowledge of the FDA, few have an appreciation of the many specific areas of FDA authority. The FDA for Doctors is not for those looking for detailed instruction on dealing with the FDA or its operations. Rather, it is written by a doctor with doctors in mind, with the hope that the information in this book will make physicians, and other readers, more thoughtful and insightful, especially with regards totherapeutics and the many broad societal issues underlying FDA's activities. With over 40 years of experience as a clinical investigator in many trials done for FDA registration, the author has been a member of and chaired an FDA advisory committee, and has been a consultant to several divisions of the FDA. He has also had the opportunity to serve on the U.S. Senate Labor Committee, helping with its FDA oversight activities. In addition to a long academic medical career the author has been a consultant to and a full time employee of drug and device companies"--Back cover.

FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label.

This book is a clinically oriented, up-to-date, and in-depth review of the various applications of FDG-PET/CT and PET/MR in cardiovascular diseases with emphasis on the current available evidence. Positron emission tomography (PET) imaging with fluorodeoxyglucose (FDG) has seen increased applications in cardiovascular diseases over the last decades. Its utility is already established in a wide range of conditions, including myocardial viability imaging, assessment of inflammatory diseases such as sarcoidosis and vasculitis, as well as imaging of infectious processes, such as infective endocarditis and cardiac implantable electronic device infection. In addition, there are several emerging indications such as the imaging of left ventricular assisting device infection and native valve endocarditis as well as new applications under investigation. The first section of the book reviews the technical basis of cardiovascular PET/CT and PET/MR imaging as well as cardiac metabolism. The following chapters each present specific pathologies, presenting epidemiology, pathophysiology, and diagnostic strategies, along with high quality clinical cases to support the discussion. The final chapter is a review of 15 interesting and clinically relevant cases. This is an ideal guide for nuclear medicine physicians, cardiologists, radiologists, residents, post-graduate fellows, and technologists.

1. Genetic, biochemical, and biophysical methods for studying Fe-S proteins and their assembly -- 2. De novo design of iron-sulfur proteins -- 3. In vitro studies of cellular iron-sulfur cluster biosynthesis, trafficking, and transport -- 4. Combined biochemical, biophysical, and cellular methods to study Fe-S cluster transfer and cytosolic aconitase repair to MitoNEET -- 5. Defining the architecture of the core machinery for the assembly of Fe-S clusters in human mitochondria -- 6. Fe-S cluster Hsp70 chaperones: the ATPase cycle and protein interactions -- 7. B. subtilis as a model for studying the assembly of Fe-S clusters in gram-positive bacteria -- 8. Structural characterization of poised states in the oxygen sensitive hydrogenases and nitrogenases -- 9. Nitorgenase assembly: strategies and procedures -- 10. TsrM as a model for purifying and characterizing cobalamin-dependent radical S-adenosylmethionine methylases -- 11. Mechanism-based strategies for structural characterization of radical SAM reaction intermediates -- 12. A polymerase with potential: the Fe-S cluster in human DNA primase -- Author index -- Subject index.

"There is an obesity epidemic in this country and poor black women are particularly stigmatized as "diseased" and a burden on the public health care system. This is only the most recent incarnation of the fear of fat black women, which Sabrina Strings shows took root more than two hundred years ago. Strings weaves together an eye-opening historical narrative ranging from the Renaissance to the current moment, analyzing important works of art, newspaper and magazine articles, and scientific literature and medical journals--where fat bodies were once praised--showing that fat phobia, as it relates to black women, did not originate with medical findings, but with the Enlightenment era belief that fatness was evidence of "savagery" and racial inferiority. The author argues that the contemporary ideal of slenderness is, at its very core, racialized and racist. Indeed, it was not until the early twentieth century, when racialized attitudes against fatness were already entrenched in the culture, that the medical establishment began its crusade against obesity. An important and original work, Fearing the Black Body argues convincingly that fat phobia isn't about health at all, but rather a means of using the body to validate race, class, and gender prejudice."--Publisher's description.

This book discusses feature engineering and computational intelligence solutions for ECG monitoring, with a particular focus on how these methods can be efficiently used to address the emerging challenges of dynamic, continuous & long-term individual ECG monitoring and real-time feedback. By doing so, it provides a "snapshot" of the current research at the interface between physiological signal analysis and machine learning. It also helps clarify a number of dilemmas and encourages further investigations in this field, to explore rational applications of feature engineering and computational intelligence in ECG monitoring. The book is intended for researchers and graduate students in the field of biomedical engineering, ECG signal processing, and intelligent healthcare.

This book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also be affected by infectious damage and clinical manifestations including Guillain-Barré syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients.

1. Introduction -- 2. Prevention of febrile neutropenia -- 3. Prediction of the risk of complications associated with febrile neutropenia -- 4. Management of low-risk patients -- 5. Management of non-low-risk patients with febrile neutropenia -- 6. Management of persistent fever in patients with neutropenia despite empirical antibiotic administration -- 7. Costs associated with febrile neutropenia -- 8. At the extremes of age, febrile neutropenia in children and elderly

Continual cell turnover is crucial for the long‐term maintenance of healthy organs, but to avoid pathological consequences, new cells must be produced at the precise rate that old cells are lost. Here we identify the signaling basis of feedback inhibition that equalizes cell production and loss during stem cell‐driven turnover of the Drosophila intestinal epithelium. E‐cadherin at the cortex of mature enterocytes inhibits EGF‐dependent stem cell divisions by repressing the EGF maturation factor rhomboid. Single, apoptotic enterocytes disrupt this inhibitory relay by degrading E‐cadherin, which de‐ represses rhomboid to activate EGFR and promote divisions of nearby stem cells. Ectopic loss of E‐cadherin in non‐apoptotic cells upregulates rhomboid, causing EGFR hyperactivation and excessive divisions. In contrast, blocking apoptosis precludes EGFR activation and slows down divisions to keep total cells constant. Thus, stem cell divisions require enterocyte apoptosis to relieve proliferative inhibition, ensuring equal rates of cell production and loss.

This book provides students and researchers with reviews of biological questions related to the evolution of feeding by vertebrates in aquatic and terrestrial environments. Based on recent technical developments and novel conceptual approaches, the book covers functional questions on trophic behavior in nearly all vertebrate groups including jawless fishes. The book describes mechanisms and theories for understanding the relationships between feeding structure and feeding behavior. Finally, the book demonstrates the importance of adopting an integrative approach to the trophic system in order to understand evolutionary mechanisms across the biodiversity of vertebrates.

In this ground-breaking book, Dr. Harold Levinson provides his follow-up work about truly understanding and successfully treating children and adults with many and diverse dyslexia-related disorders such as those found on the cover. This fascinating, life-changing title is primarily about helping children who suffer from varied combinations and severities of previously unexplained inner-ear-determined symptoms resulting in difficulties with: reading, writing, spelling, math, memory, speech, sense of direction and time grammar, concentration/activity-level, balance and coordination headaches, nausea, dizziness, ringing ears, and motion-sickness frustration levels and feeling dumb, ugly, klutzy, phobic, and depressed impulsivity, cutting class, dropping out of school, and substance abuse bullying and being bullied as well as anger and social interactions later becoming emotionally traumatized and scarred dysfunctional adults Feeling Smarter and Smarter is thus also about and for the millions of frus-trated and failing adults who are often overwhelmed by similar and even more complicated symptoms—as well as for their dedicated healers. Having laid the initial foundations for his many current insights in an earlier bestseller, Smart But Feeling Dumb, Dr. Levinson now presents a compelling range of enlightening new cases and data as well as a large number of highly original discoveries—such as his challenging illumination that all dyslexia-related manifestations are primarily inner-ear or cerebellar-vestibular—not cerebrally—determined and so do not impair IQ, and an “ingeniously simple” explanatory theory of symptom formation. -- Provided by publisher.

"Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Continuing the long-standing Feigenbaum tradition as an authoritative, comprehensive echocardiography resource, the thoroughly revised Feigenbaum's Echocardiography, Eighth Edition, helps echocardiographers, fellows, clinicians, and sonographers master the art and science of echocardiography and stay current with all that's new in the field. Written by William F. Armstrong and Thomas Ryan, it guides you through pertinent physics, technology, clinical applications, and new developments in the field. As in the past, the book is written primarily for the practitioner who uses echocardiographic methods to care for and manage patients, with a focus on appropriate clinical applications.Features enhanced online content including echo clips, case studies, and more.Includes new content specifically for cardiac sonographers. Reflects new training guidelines for cardiology fellows emphasizing the importance of echocardiography in the general practice of cardiology.Describes the interrelationship of other imaging technologies with echocardiography and the role of echo as part of a multimodality approach to patients. Contains more than 1,600 high-quality illustrations - 600 in full color.Covers the use of 3D echocardiography and perfusion imaging; current AHA/ACC guidelines, appropriate use guidelines, and the mechanics and utility of strain and strain rate imaging.Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone Customize for your language</B>, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages Easily convert to audiobook, powering your content with natural language text-to-speech Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"--Provided by publisher.

"Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases"--Publisher's description.

Bd. 1. Zur normalen Anatomie und Physiologie sowie allgemeinen Pathologie des feinsten Gefässabschnittes beim Menschen.

Handling, restraint, and pre-anesthetic assessment -- Anatomy, physiology, and pharmacology -- Sedation and premedication -- Injectable anesthetics and induction of anesthesia -- Local anesthetics and loco-regional techniques -- Inhalation and balanced anesthesia -- Monitoring -- Fluid therapy -- Anesthetic management of special conditions -- Anesthetic complications -- Mechanisms of pain -- Assessment and recognition of acute pain -- Treatment of acute (adaptive) pain -- Assessment and recognition of chronic (maladaptive) pain -- Treatment of chronic (maladaptive) pain.

This richly-illustrated handbook covers all aspects of modern feline dermatology, from the approach to different signs and symptoms to the description of the etiology, pathogenesis, clinical manifestation, diagnosis and current treatment of each feline dermatological disease. Thus this manual serves as essential practical guide to the busy practitioner to quickly and surely tackle cats with dermatological conditions, and offers a current and complete reference tool for the feline veterinarian and the veterinary dermatologist.

The radiographic examination : the basics -- Cross-sectional imaging techniques -- The normal chest x-ray : reading like the pros -- Chest CT : putting it all together -- Lobar anatomy -- The silhouette sign -- The air bronchogram sign -- Signs of lung and lobar collapse -- Patterns of lung disease -- Understanding the mediastinum -- The pleural and extrapleural spaces -- Cardiovascular disease.

Felson’s ten axioms for a lifetime of learning in medicine -- The radiographic examination: the basics -- Cross-sectional imaging techniques -- The normal chest x-ray: reading like the pros -- Chest CT: putting it all together -- Lobar anatomy -- The silhouette sign -- The air bronchogram sign -- Signs of lung and lobar collapse -- Patterns of lung disease -- Understanding the mediastinum -- The pleural and extrapleural spaces -- Cardiovascular disease -- Quiz: ten great cases.

Few dermatologic problems carry as many emotional overtones as hair loss in women, which is by far the most common hair problem encountered in daily clinical practice. Fortunately, a specific diagnosis can usually be established through a detailed patient history, examination of the scalp and pattern of hair loss, a simple pull test, dermoscopy of the scalp and hair (trichoscopy), a few pertinent screening blood tests, and, in selected cases, a scalp biopsy. Once the diagnosis has been established, treatment appropriate to the diagnosis is likely to control the problem. The aim of this comprehensively illustrated monograph is to provide both specialists and primary care physicians with the practical know-how required for successful management of hair loss in female patients of all ages. The book opens by critically examining myths about hair loss. The different examination techniques are then described, and the various forms of hair loss and their treatment are discussed in detail. Approaches to follow-up are outlined, and the management of patient expectations is carefully considered. The potential role of hair care and cosmetics is also explored in some depth.

This book provides healthcare professionals, the medical community, residents and students with an up-to-date handbook on current female and male contraceptive options. It illustrates the process of contraceptive development, from ancient times to steroid discovery up to the most recent formulations that provide not only an optimal contraceptive efficacy but also complimentary health benefits for women. It offers a comprehensive overview of the current knowledge on this topic, ranging from biological contraceptive mechanisms to the challenges of contraceptive use in different clinical conditions. It also presents reviews of the current latest, including preclinical and clinical research, to provide detailed and up-to-date information on recently developed contraceptives. It also features a section on counseling, which is highly relevant to optimal contraceptive provision and compliance. Each chapter has been written by a leading expert in the field and provides a comprehensive reference on the topic as well as practical implications. As such, this book provides accessible and authoritative information for clinicians in their everyday practice and for students interested in expanding their knowledge on the topic.

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

This is the first book of its kind to focus solely on the female athlete triad - its origins, its recognition, and most importantly, its management. Since the symptoms themselves cover a range of medical specialties, chapters are written by experts in a number of relevant fields - sports medicine, orthopedics, endocrinology, and pediatrics - with an eye toward overall care of the young female athlete. Additionally, each chapter includes suggestions on how to educate and communicate with young athletes and their parents, as well as trainers and coaches, on how to manage the illness outside of the direct clinical setting. The female athlete triad is often seen in sports where low body weight is emphasized, such as gymnastics, figure skating, and running, though it can appear in any sport or activity. The interrelated symptoms - eating disorders, amenorrhea, and low bone mass - exist on a spectrum of severity and are serious and potentially life-threatening if not properly treated. Psychological problems, in addition to medical ones, are not uncommon. The Female Athlete Triad: A Clinical Guide discusses all of these areas for a well-rounded and in-depth approach to the phenomenon and will be a useful reference for any clinician working with female athletes across the lifespan.

Urinary symptoms in women have a very high prevalence rate. While the storage function of the bladder is similar in both genders, voiding function has marked differences with obvious anatomic and physiological genitourinary distinctions. Despite all advances in contemporary diagnostics and imaging, female bladder outlet obstruction and urethral stricture disease remain a conundrum to be deciphered in clinical practice. It is also seen that the female voiding symptoms and bladder outlet obstruction are poorly understood entities; which is also evident from the fact that Urethral dilatation in women is still a widely practiced procedure. This book provides a comprehensive understanding of female voiding disorders leading to bladder outlet obstruction and helps identify the women who will actually need reconstructive surgeries. The book begins with what is normal female voiding and then goes on to describe the various definitions of female bladder outlet obstruction along with controversies in Urodynamic diagnosis . As the functional causes are more common than actual strictures, this book elucidates on the knowledge of each of these differentials with their basic understanding and treatment outline, further throwing knowledge on the anatomical causes like pelvic organ prolapse and female urethral stricture. A separate section is dedicated to female urethral surgical anatomy and urethral reconstruction for urethral stricture as well as pelvic fracture urethral injury in females.

Anatomy and classification of the female genitalia : implications for surgical management / Paul E. Banwell -- Psychosocial issues and social mores in female genital aesthetic surgery : what is normal? / Kharen Ichino, Jennifer L. Walden -- Informed consent and liability in cosmetic genital surgery / Neal R. Reisman -- Labial reduction : surgical wedge technique / Christine Hamori -- Labia minora reduction surgery : curved linear resection / Red Alinsod -- Labia majora reduction surgery : majoraplasty / Red Alinsod -- Clitoral hood reduction techniques / Otto J. Placik -- Augmentation of the labia majora with fat grafting / Lina Triana, Mildred M. Martínez, Paul E. Banwell -- Augmentation of the labia majora with fillers / Nicolas Berreni -- Complications of female cosmetic genital surgery / Christine Hamori -- Perineoplasty and vaginoplasty / Marco Pelosi II, Marco Pelosi III -- Hymenoplasty / Otto J. Placik -- Auxiliary procedures / Clara Santos, Red Alinsod -- Future avenues and advances / Colin C.M. Moore -- O-shot / Charles Runels -- Transcutaneous temperature-controlled radiofrequency for vulvovaginal rejuvenation / Red Alinsod -- Fractional erbium laser for vaginal rejuvenation / Evgenii Leshunov.

This book reviews the promising new electrocardiographic (ECG) predictors of cardiac morbidity and mortality with the primary objective being to evaluate gender differences in special ECG features and in ECG predictors for the risk of adverse cardiac events and to explore mechanisms for gender differences in risk predictors. The Female Electrocardiogram elucidates the emergence of gender differences in ECG features and evaluates repolarization-related ECG predictors of various clinical disease categories with a special scope to interpret the mechanism and gender differences of the findings. The author examines how the predictors of adverse cardiac events are linked to basic electrophysiological finding whenever adequate information is available in this rapidly advances realm of research. The overall goal of the book is to facilitate understanding of the mechanisms and clinical relevance of repolarization abnormalities in both clinical and epidemiological applications, and as such will be of great interest to all who manage patients using ECG whether they be cardiac electrophysiologists, clinical cardiologists, critical care physicians or any medical professional in the disciplines covered.

An analysis of the cultural and economic drivers of the growing phenomenon of FGCS, written by cross-disciplinary experts, this book challenges the concept of individual consumer choice in FGCS: a decision that is rarely exercised in a socio-cultural vacuum. Four distinct aspects of FGCS are covered: variations in female genital anatomy; surgical techniques and evidence; historical contexts and ethical dilemmas; norm-critical understandings to inform professional responses. Rendering philosophical critiques accessible, and exposing dubious social values that underpin the practice, this text is crucial in driving a broader understanding of FGCS as a cultural phenomenon of our times. Only with a fuller understanding of the multiple perspectives of FGCS, can there be sensible alternatives for women and girls psychologically troubled by their natural, healthy form. Offering explanations and interventions at individual, institutional and societal levels, this text will be valued by both professional and non-professional audiences.

This book uses global household data to examine the prevalence, trends and geographic variation of female genital mutilation (FGM) around the world. It also addresses the underlying legal and policy aspects as well as explores the medical consequences, both immediate and long term, for those undergoing the practice. The book analyses the position of victims of this gender-based violence both from the medical and legal perspective and adopts a largely practical approach to the study of the practices, offering a fresh thinking into one of the challenges in global health and the law. In addition, it offers some insights into how health professionals can approach this category of victims and how legal practitioners can obtain a good legal result for their clients before domestic and international forums. The book addresses fundamental issues such as state liability and defences in enforcement proceedings for actions or omission of state or non-state actors, and due diligence standard in international human rights law, the main gateways available for obtaining relief for the victims of FGM. This book goes beyond the traditional debate between zero tolerance and those who wish to see the practice medicalised and tolerated and favours an advocacy programme standing firmly in favour of the right of FGM victims. This book offers a unique perspective likely to assist victims and their representatives to secure a remedy against perpetrators and the state. As such this book will be of interest to medical professionals, national and international lawyers, academics and policymakers in the field of public health.

This open access illustrated guide focuses on Female Genital Mutilation/Cutting (FGM/C) in children and adolescents. FGM/C comprises all procedures that involve partial or total removal of the external female genitalia or injury to the female genital organs for nonmedical reasons. It is mainly carried out during childhood, before the age of 15. The signs of FGM/C can be subtle, and the examiner must be trained with a wide range of normal genitalia both before and after puberty, FGM/C types and subtypes, complications and differential diagnosis. This volume is a reference containing iconographic material of both pre and post pubertal genitals with and without genital cutting. This book will guide health care professionals in making the correct diagnosis, outline the clinical management, enhance patients provider communication, and will enable accurate recording and reporting to governments where required.

Genital plastics : the history of development / Michael P. Goodman, with contributions from David Matlock -- Anatomic considerations / Orawee Chinthakanan, Robert D. Moore, John R. Miklos -- Definitions / Michael P. Goodman -- Philosophy, rationale, and patient selection / Michael P. Goodman -- Ethical considerations of female genital plastic/cosmetic surgery / Andrew T. Goldstein, Sarah L. Jutrzonka -- Patient protection and pre-operative assessment / Michael P. Goodman -- Surgical procedures I : vulva and mons pubis / Michael P. Goodman, with contributions from David Matlock, Alex Simopoulos, Bernard W. Stern, Otto J. Placik -- Surgical procedures II : perineoplasty, vaginoplasty, colpoperineoplasty ("vaginal rejuvenation") / Robert D. Moore, John R. Miklos, Orawee Chinthakanan -- The biomechanics and physiology of clitoral and vaginally activated orgasm : impact of vaginal tightening operations / Michael P. Goodman -- The G-spot / Dudley Robinson, Linda Cardozo -- Post-operative care / Michael P. Goodman -- Aesthetic male-to-female transsexual surgery / Marci Bowers -- Anesthetic choices and office based surgery / Michael P. Goodman -- Non-surgical cosmetic vulvo-vaginal procedures / Gustavo Leibaschoff, Pablo Gonzalez Isaza -- Surgical risks and untoward outcomes / Otto J. Placik -- Revisions and re-operations / Michael P. Goodman -- Psychosexual issues / Michael P. Goodman -- Outcomes / Michael P. Goodman -- Pearls for practice / Michael P. Goodman -- Standards of care / Michael P. Goodman.

Part 1: basics -- 1. Normal embryological development of the female genital tract -- 2. Pathogenesis and aetiology of female genital malformations -- 3. Implantation in women with uterine congenital malformations -- 4. Classification of female genital malformations.-Part 2: Screening and diagnosis of female genital malformations -- 5. Hysterosalpingography -- 6. 2D Ultrasound and sonohysterography for the diagnosis of Female Genital Anomalies -- 7. 3D Ultrasound -- 8. Magnetic resonance imaging for the Diagnosis of Female Genital Anomalies -- 9. Diagnosis of Uterine Congenital Anomalies: Endoscopy -- 10. Current Work-Up for Screening And Diagnosing Female Genital Malformations -- Part 3: Clinical implications of the female genital malformations -- 11. Prevalence in the general and selected populations -- 12. Health problems related to female genital malformations: obstructive and complex anomalies -- 13. Fertility in women with uterine anomalies -- 14. Pregnancy outcome in women with uterine anomalies -- 15. Cervical Weakness in women who have uterine anomalies: Impact on pregnancy outcomes.- Part 4: Treatment of vaginal aplasia / techniques and results -- 16. Frank dilators -- 17. Vulvo-Perineoplasty Creatsas Vaginoplasty -- 18. Neovagina formation with expansion of vaginal vault -- 19. Neovagina formation with the use of peritoneum -- 20. Neovagina formation with the use of bowel -- 21. Vaginal Aplasia: Critical Overview of Available Treatment Options -- Part 5: Treatment of obstructive anomalies -- 22. Vaginal septae and imperforate hymen -- 23. Treatment of Obstructing Anomalies: Cervical aplasia -- 24. Treatment of Patients with Non-communicating Horns with Cavity -- Part 6: Treatment of uterine malformations -- 25. T-shaped uterus -- 26. Septum resection: Techniques and Post-Treatment Reproductive Performance -- 27. Bicorporeal uterus: treatment options -- 28. Bicorporeal Uterus: Laparoscopic Metroplasty -- Part 7: Disorders of sex development -- 29. Disorders of Sex Development: Classification and Treatment.

This book is designed as a guide for management of advanced clinical scenarios encountered by the contemporary pelvic floor surgeon. It is organized by pelvic floor disorder (PFD) and covers the evaluation and treatment of urinary incontinence, fecal incontinence, and pelvic organ prolapse. Opening chapters in each section cover the fundamentals of proper and comprehensive assessment of patient PFDs, as well as the treatment options that are available for each disorder. The book then focuses on more complex and challenging situations that are becoming more frequently encountered as the number of patients being treated for PFD increases and the length of patient follow-up grows. Each chapter finally includes an expert commentary to address these new scenarios and offers a shifted approach from that required for treatment-naive patients. Female Pelvic Medicine: Challenging Cases with Expert Commentary teaches the reader how to approach the most difficult of clinical situations in a multidisciplinary fashion. .

Female Pelvic Surgery provides a comprehensive, state-of-the-art surgical review of this field and will serve as a valuable resource for clinicians and surgeons. The text reviews the basic indications for treatment and details the many surgical approaches to the management of all pelvic floor disorders. In addition to step-by-step description in text, the volume provides illustrations/photographs of surgical techniques. Integration of surgical methods demonstrating the major repairs described in each section augment the textbook and serve as the tool for the education of clinicians and surgeons. Female Pelvic Surgery provides a concise and comprehensive review of all the surgical approaches to female pelvic surgery and thus it will serve as an extremely useful resource for physicians dealing with and interested in the treatment of pelvic floor disorders.

The fully updated edition of this text provides a state-of-the-art surgical review of female pelvic surgery, and will serve as a valuable resource for clinicians and surgeons dealing with, and interested in the treatment of pelvic floor disorders. The book reviews the basic indications for treatment and details the many surgical approaches to the management of all pelvic floor disorders, including stress urinary incontinence, transvaginal prolapse, transabdominal sacrocolpopexy, robotic/laparoscopic sacrocolpopexy, vaginal and vulvar cysts, and interstitial cystitis/bladder pain syndrome. In addition to step-by-step descriptions, the text is augmented with illustrations and photographs of surgical techniques demonstrating the major repairs described in each section. Written by experts in their fields, the second edition of Female Pelvic Surgery provides a concise and comprehensive review of all surgical approaches to female pelvic surgery.

Female Puberty: A Comprehensive Guide for Clinicians is a practical reference, covering the full range of issues related to pubertal development. Developed to answer pointed clinical questions and to provide a thorough review of the literature, the book covers both the basics and the complexities of puberty, encompassing psychosocial development to pubertal nuances in highly specialized populations. Comprehensive in scope, this title offers concepts that are concisely conveyed and chapters that complement each other well. Complex subjects such as details of the hypothalamic-pituitary-ovarian axis are covered in a readily understandable manner, and bullet points throughout the text serve as helpful reminders to the reader. An invaluable contribution to the literature, Female Puberty: A Comprehensive Guide for Clinicians will be of great interest to all health providers concerned with female reproductive health - including obstetrician gynecologists, reproductive endocrine specialists, pediatricians, pediatric specialists, family practitioners, and allied health professionals.

Part I Hypothalamic-Pituitary-ovary axis disorders: The hypothalamus-pituitary-ovary axis -- The menstrual cycle and related disorders -- The Polycystic ovary syndrome -- Menstrual disorders related to endocrine diseases -- The menstrual disorders related to systemic diseases -- Hormones and sex behaviour -- Hormonal contraception -- Part II Uterine disorders: Endometriosis -- Uterine fibroids and adenomyosis -- Abnormal uterine bleeding -- Part III Infertility: Infertility -- Diagnostic protocols -- Hormonal treatments -- Assisted reproductive technologies -- Part IV Menopause: Premature ovarian insufficiency -- Climacteric syndrome -- Long-term consequences of menopause -- Hormone replacement therapy (HRT) -- Menopause and bone metabolism -- Part V Pregnancy: Endocrinology of maternal-placental axis -- The "great obstetrical syndromes" -- Part VI Breast: Hormones, breast disorders and lactation.

Sociocultural considerations / Donata Villari -- Anatomical and physiological description of women's sexuality / Serena Maruccia and Angela Maurizi -- Female sexuality: a state of mind / Linda Vignozzi -- Evaluation systems of female sexual function / Maria Teresa Filocamo and Nadine Di Donato -- Becoming a woman: when and why gender dysphoria may challenge the basic steps of women's sexual identity / Alessandra Graziottin -- Endometriosis and sexuality / Nadine Di Donato and Renato Serachhioli -- POP and impact of surgery on female sexual life / Montserrat Espuña Pons, Franca Natale, and Elisabetta Costantini -- Urinary incontinence and mid-urethral slings: which is the impact on female sexual life? / Elisabetta Costantini -- Female sexual life during malignancies / Donata Villari -- Sexuality in couples with reproductive difficulties / Lucia Alves Silva Lara -- Sexuality after abuse / Valeria Dubini -- Female sexual dysfunction in alcohol and drug abuse / Marina Ziche -- Female sexual function during male sexual dysfunction and vice versa / Maria Antonella Bertozzi and Valeria Ales -- Female sexuality in chronic pelvic pain / Antonella Giannantoni -- Female sexual function and neurological disease / Elena Andretta -- Female genital cosmetic surgery / Sushma Srikrishna and Linda Cardozo -- Role of physical therapy in the treatment of female dysfunction / Merete Kolber Tennfjord, Marie Ellström Engh, and Kari Bø.

This book provides a comprehensive review of the etiology, anatomy, diagnosis, treatments, and future directions of care for female incontinence. It includes a historical review of past treatments many women have undergone and resultant altered anatomy. This book discusses conservative treatments such as patient and provider handouts on behavioral modification and how to perform pelvic floor exercises. It also covers medical therapy from minimally invasive treatments to radical surgical approaches and management of treatment failures. Addressing the treatment of stress incontinence with chapters progressing from least invasive to most invasive therapies, it also describes mesh complications and treatment failures. The book illuminates the intersection of prolapse with female incontinence, incontinence diagnosis and management after major reconstructions such as neobladder or penile inversion, vaginoplasty, and incontinence due to rarer conditions such as fistulas. Further chapters explore female urinary incontinence in special populations including pediatric patients, the elderly, and women with neurogenic lower urinary tract dysfunction, as well as poorly understood populations such as older children, women post-reconstruction, and trans-women. It also addresses research needs and the ever-expanding horizon of new developments in the field of incontinence in women. Female Urinary Incontinence provides a comprehensive text directed towards urologists, gynecologists, and those trained in female pelvic medicine and reconstructive surgery (FPMRS). Given the topic of incontinence specifically in women and the burgeoning rise of women in the field of FPMRS, the book features an all-female author list comprised of an international group of female urologists and urogynecologists selected to author chapters on their particular expertise.

This book comprehensively covers the latest consensus in the diagnosis and management of patients with recurrent Urinary Tract Infections (UTIs). It features a broad overview of the basic science and the spread of antibiotic resistance in UTIs. Guidelines are provided on the recommended approaches for using antibiotics including dosage, duration, resistance rates for a range of antibiotics, and available methods for combating antibiotic resistance. Further topics covered include prophylaxis, including conservative lifestyle modifications as well as preventative therapies. Female Urinary Tract Infections in Clinical Practice summarises the basic science, use of antibiotics, and preventative strategies for UTIs and represents a timely and valuable resource for all practising and trainee medical professionals who encounter these patients in their practice. .

"What is feminism? In this short, accessible primer, bell hooks explores the nature of feminism and its positive promise to eliminate sexism, sexist exploitation, and oppression. With her characteristic clarity and directness, hooks encourages readers to see how feminism can touch and change their lives--to see that feminism is for everybody"-- Provided by publisher.

When Feminist Theory: From Margin to Center was first published in 1984, it was welcomed and praised by feminist thinkers who wanted a new vision. Even so, individual readers frequently found the theory "unsettling" or "provocative". Today, the blueprint for feminist movement presented in the book remains as provocative and relevant as ever. Written in hook's characteristic direct style, Feminist Theory embodies the hope that feminists can find a common language to spread the word and create a mass, global feminist movement. hooks is Distinguished Professor in Residence in Appalachian Studies at Berea College, and resides in her home state of Kentucky. (Back cover).

This practical book combines thorough literature review with extensive clinical experience to provide a clear overview of femoral revision arthroplasty, with the aim to present all available surgical techniques and critically discuss pros and cons and evidence-based recommendation for each of them. A wealth of figures and several videos complement the book and guide the reader through the management of potential pitfalls and complications during and after surgery. Particular emphasis is further put on the comparison of different approaches, stem types, and fixation techniques, assisting readers in identifying the best indication. Designed as a practically-oriented tool this book offers an excellent resource for all specialist hip surgeons and fellows wishing to gain insights into this complex and challenging surgical procedure.

The femtosecond laser has emerged as a groundbreaking game-changer in ophthalmic surgery. It was first introduced for corneal refractive surgery in flap creation during LASIK, and subsequently for cataract surgery in 2008. The femtosecond laser cuts deeply on a single plane without collateral damage. Its high precision and safety result in excellent outcomes in the hands of experienced eye surgeons, benefiting virtually everyone. Femtosecond Laser Surgery in Ophthalmology fills an unmet need for a comprehensive, up-to-date resource on growing applications of this state-of-the-art technology.

1. Paroxysmal disorders -- 2. Altered states of consciousness -- 3. Headache -- 4. Increased intracranial pressure -- 5. Psychomotor retardations and regression -- 6. The hypotonic infant -- 7. Flaccid limb weakness in childhood -- 8. Cramps, muscles stiffness, and exercise intolerance -- 9. Sensory and autonomic disturbances -- 10. Ataxia -- 11. Hemiplegia -- 12. Paraplegia and quadriplegia -- 13. Monoplegia -- 14. Movement disorders -- 15. Disorders of ocular motility -- 16. Disorders of the visual system -- 17. Lower brainstem and cranial nerve dysfunction -- 18. Disorders of cranial volume and shape.

Paroxysmal disorders -- Altered states of consciousness -- Headache -- Increased intracranial pressure -- Psychomotor retardation and regression -- The hypotonic infant -- Flaccid limb weakness in childhood -- Cramps, muscle stiffness, and exercise intolerance -- Sensory and autonomic disturbances -- Ataxia -- Hemiplegia -- Paraplegia and quadriplegia -- Monoplegia -- Movement disorders -- Disorders of ocular motility -- Disorders of the visual system -- Lower brainstem and cranial nerve dysfunction -- Disorders of cranial volume and shape.

Providing optimal health care for LGBT people: changing the clinical enviroment and education professionals -- What we know and don't know about LGBT demographics: informing clinical practice -- Intersectionality: implications for clinical care of LGBTQ people -- Coming out: the process of forming a positive identity -- Caring for LGBTQ youth -- LGBT relationships and family lives -- Caring for LGBT older adults -- Principles for taking an LGBTQ-inclusive health history and conducting a culturally competent physical exam -- Mental health care for LGBT people -- Clinical management of substance use and substance use disorders among LGBT individuals -- Intimate partner violence and hate crimes: recognition, care, and prevention for LGBT people -- Sexual health of LGBTQ people -- HIV/AIDS prevention for sexual and gender minority people -- Community, structural, and policy approaches to improve HIV prevention and related health concerns among racial/ethnic minority gay, bisexual, and other men who have sex with men -- Self-discovery: a toolbox to help clinicians communicate with clarity, curiosity, creativity, and compassion -- Gender nonconformity and gender discordance in childhood and adolescence: development considerations and the clinical approach -- Creating a foundation for improving trans health: understanding trans identities and health care needs -- Medical and surgical management of the transgender patient: what the primary care clinician needs to know -- Policy and legal issues affecting LGBT health -- LGBT health: global perspectives and experiences -- Appendix A: Suggestions for creating an inclusive and welcoming environment for LGBT patients and staff -- Appendix B: Sample sexual orientation and gender identity questions for patient registration and intake forms -- Appendix C: Selected resources on LGBT health -- Appendix D: Patient registration and medical history forms.

Ferraro's Fundamentals of Maxillofacial Surgery, 2e is the newly revised and updated second edition of the text originally edited by James W. Ferraro. Written for trainees and students, as well as experts in oral and maxillofacial surgery, and experts in related subspecialties such as otolaryngology and plastic surgery, this highly illustrated text is an invaluable source of hands-on, practical knowledge for those taking the ASMS Basic Course, or for any specialist seeking a comprehensive review of maxillofacial surgery.

Evaluation of skin disorders -- Differential diagnosis -- Diseases and disorders -- Appendices. Topical steroids -- Cutaneous manifestations of internal disease -- Nail diseases -- Stings and bites.

For nearly 25 years, Ferri's concise, pocket-sized resource has served as the go-to reference for practical, clinical information among students, residents, and other medical professionals. Formerly known as Practical Guide to the Care of the Medical Patient, this volume continues to provide a fast, effective, and efficient way to identify the important clinical, laboratory, and diagnostic imaging information you need to get through your internal medicine clerkship or residency. Benefit from the expert guidance of Dr. Fred Ferri, a leading teacher, clinician, and author.Confidently manage patients with the latest clinical information, drug therapies, and lab tests.

This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.

This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research.

This book covers all forms of Congenital Adrenal Hyperplasia (CAH) and provides a comprehensive overview of accompanying reproductive problems. Affected individuals may exhibit low fecundability, infertility, recurrent miscarriages, painful sexual intercourse, sexual orientation changes, etc. If not diagnosed and treated properly, their children may also experience developmental disorders of the external genitalia. Depending on the defects in enzymes, severity of the mutations and residual enzymatic activities, the clinical presentation may differ from patient to patient. As these disorders are encountered relatively rarely, many cases are either undiagnosed or inappropriately treated. Given its scope, this book offers a valuable guide for gynecologists, endocrinologists, pediatricians, and professionals in reproductive medicine, as well as GPs, practicing physicians, medical students and residents.

This book, written by global experts in the field, provides a thorough overview on fertility and pregnancy challenges and solutions in women who are being or have been treated for cancer. The book addresses several topics, including pregnancy outcomes after a cancer diagnosis, the impacts of systemic anticancer therapy on fertility, the essentials of fertility preservation approaches in cancer patients, and fertility counseling. This is in addition to controversial topics like the role of ovarian stimulation in breast cancer patients, fertility preservation in cancer patients with BRCA mutation and the evolving role of GnRH analogues. Within this context, key open questions are discussed with reference to the latest evidence. The aim is to provide clinicians with a reliable resource that documents the most up-to-date knowledge on the feasibility and safety of the different approaches to fertility preservation and on the management of female cancer patients who would like to preserve fertility and achieve a pregnancy following their treatment.

This practical book focuses on the most recent advances in fertility preservation in oncological and non-oncological patients. It presents the steps that need to be followed prior to treatment for successful fertility preservation, and describes in detail the medical conditions requiring fertility preservation, including precise information on the risk of fertility loss, prognosis, risk of ovarian metastasis and other possible risks. The book also provides information on how to perform the preservation techniques (success rates, risks, etc.) and on what to do after the treatment (in cases of bleeding during chemotherapy, menopause, wish to conceive, etc.). Written by experts in the field, including members of the globally known network FertiPROTEKT and leading oncologists and specialists, this practical and easy-to-use book is a valuable resource for all clinicians involved in fertility preservation for patients with specific diseases.

"This book introduces readers to the fascinating interaction of specialized gamete cells, forming the early embryo and a blueprint of new life. Gain a thorough understanding of the complex physiological events and biochemical processes--such as ionic regulation, metabolism and intracellular signalling--to decipher cause and effect in fertilization. Wide-ranging in its approach, this book describes fertilization as a highly conserved mechanism throughout the animal kingdom, taking case studies from echinoderms, ascidians, amphibians, mammals through to other phyla. An excellent companion to undergraduate and postgraduate students of medicine, veterinary and biological sciences; this text provides an underpinning of the mechanisms of fertilization that will inform assisted reproduction practice and research in medicine and agriculture. Explore the detailed phases before fertilization: the oocyte as a quiescent cell, attracting its partner gamete, followed by a cascade of pre-determined physiological events, to form the dynamic zygote cell; setting the scene for the early embryo, and beyond."--Page 4 of cover.

Part I-Introductory aspects in fetal procedures/Ethical aspects of fetal heart interventions -- Tools in fetal heart procedures -- Role of Multicenter Registries to Assess Outcomes of Fetal Interventions -- Role of Counseling in Fetal Congenital Heart Diseases -- Part II -- Aortic valve disease/Fetal Anatomy: the aortic valve in the fetal aortic valve diseases -- Fetal aortic stenosis -- natural history and echocardiographic evaluation -- Fetal Aortic Valvuloplasty (FAV) -- Fetal aortic valvuloplasty: state of art -- Part III -- Pulmonary valve disease/Fetal anatomy: the pulmonary valve in the fetal pulmonary valve disease -- Fetal pulmonary valvuloplasty: Natural history and echocardiographic evaluation of Critical Pulmonary stenosis/ Pulmonary atresia with intact ventricular septum -- Indications for fetal pulmonary valvuloplasty -- Center experience and step-by-step approach for fetal pulmonary valvuloplasty -- Pulmonary valvuloplasty: Fetal, neonatal and follow up outcomes -- Literature on fetal therapy after pulmonary valvuloplasty -- Future perspectives on fetal pulmonary valvuloplasty -- Part IV -- Procedures on the interatrial septum/The embryology of the interatrial septum -- Fetal anatomy: the inter atrial septum in the fetus with congenital heart disease -- Literature on fetal therapy on interatrial septum -- Procedures on the Atrial Septum -- Part V -- Fetal procedures: Other treatments and approaches/Perspectives On Fetal Pacing -- Alternative vascular access in fetus -- Part VII -- Introductory aspects in hybrid procedures/Physician's Perspective -- Parents' Perspective on the Hybrid Approach -- The Hybrid Catheterization Laboratory -- Part VIII -- Hypoplastic Left Heart Syndrome (HLHS)/Hypoplastic left heart syndrome natural and surgical history -- The engineering perspective -- General principles of the hybrid approach in Hypoplastic Left Heart Syndrome -- Hypoplastic Left Heart Syndrome: The Giessen approach -- history, technique and results -- Hybrid Approach: The Columbus way -- The Brazilian Hybrid Approach for Hypoplastic Left Heart Syndrome -- Canadian approach to hybrid HLHS.-Prolonged Right Ventricle To Left Ventricle Support (Hybrid Or Surgical) To Delay Decision Making In Borderline Left Ventricles -- The Anatomical or Functional Borderline Left Ventricle and Strategies for Staged Rehabilitation -- Part IX -- Pulmonary Arteries/Pulmonary arteries: surgical point of view -- Exit Angiography -- Role of 3-Dimensional Rotational Angiography in Imaging the Pulmonary Arteries -- Hybrid Approach to Pulmonary Artery Stenosis -- Literature and Results -- Part X -- Ventricular Septal Defect/Hybrid Closure of Muscular Ventricular Septal Defects: anatomy, clinical scenarios and techniques -- Hybrid Muscular Ventricular Septal Defect Closure: Literature And Results -- Perimembranous VSD -- Part XI -- Other Hybrid Procedures/Hybrid Atrial Septal Defect Closure -- Treatment of RV Outflow Tract Dysfunction: New Valve Technologies -- Mitral Valve Replacement with Melody Valve Prosthesis -- A Hybrid Approach to Aortic Stent Implantation -- Other hybrid treatments: tetralogy of Fallot -- Other hybrid treatments: RV-to-PA hybrid conduit -- Hybrid VSD creation or enlargement.

This richly illustrated book discusses the fetal eye, offering a brief introduction to the topic and discussing its development and treatment. The high-quality reference images allow the morphological fetal age to be determined, and the authors provide examples of artifacts and real-world findings to simplify histopathological diagnosis. The book also discusses findings in fetal eyes, presenting typical examples of common malformations, including clinical and histological pictures as well as additional findings from other specialties (such as neuropathology, genetics). In addition, it covers non-specific ocular malformations. It particularly addresses documentation and interpretation of cases of suspected Shaken-Baby Syndrome, which is of forensic importance. In the context of retinopathy of prematurity, histopathological and clinical findings are correlated.

Drs. Richard Polin and Alan Spitzer, uses the success formula of the Secrets Series to offer fast answers to the most essential clinical questions in fetal and neonatal medicine. With its user-friendly Q & A format, practical tips from neonatologists and fetal medicine experts, and "Key Points" boxes, this portable and easy-to-read medical reference book provides rapid access to the practical knowledge you need to succeed both in practice and on board and recertification exams. New to this edition: Apply all the latest pediatric advances in clinical fetal neonatology techniques, technology, and pharmacology.

This practical book describes a systematic approach to the ultrasound examination of the fetal heart based on accepted screening recommendations. The written content is enhanced by images and videos of both normal and abnormal sonographic findings. Fetal Cardiology: A Practical Approach to Diagnosis and Management goes further than simply describing core screening views. It includes extended views of the fetal heart, the use of Doppler techniques and assessment of fetal cardiac function. “Variants” which can be encountered in practice are described as well as the features of the major groups of cardiac abnormalities and fetal arrhythmias. Because the authors include experienced fetal and paediatric cardiologists, the focus is not only on diagnostic features but also the approach to postnatal care and prognosis. This content is enhanced by inclusion of chapters relating to associated fetal abnormalities, the genetics of congenital heart disease and new imaging modalities such as MRI of the fetal heart. The book equips all those using ultrasound to image the fetus with a clear concise reference to meet the challenge of new guidelines and to expand their knowledge of complementary echocardiographic techniques and management. It details why prenatal recognition of congenital heart disease is being prioritised to allow for parental choice, recognition of associated abnormalities and improvement of postnatal outcome. As such, this book will be important for all professionals, whether they be a cardiologist, fetal medicine specialist, sonographer or midwife.

Early concepts and terminology -- Cellular mechanisms and embryonic tissues -- Staging embryos in development and the embryonic body plan -- Teratology -- Early pregnancy failure -- The immunology of implantation -- Development of the placenta and its circulation -- Placental function in maternofetal exchange -- Placental pathology and implications for fetal medicine -- Development of the heart and cardiovascular system in relation to cardiac abnormalities -- Lung growth and maturation -- Development of the kidneys and urinary tract in relation to renal anomalies -- The perinatal postmortem examination -- Epidemiologic and research methods in fetal medicine -- Ethical issues in maternal-fetal medicine -- Principles of screening -- Conveying information about screening and diagnosis -- Ultrasound and biochemical screening for fetal aneuploidy -- Ultrasound screening for fetal abnormalities in the first trimester -- Evidence for routine ultrasound screening for fetal abnormalities in the second and third trimesters -- Noninvasive screening for cytogenetic disorders (fetal aneuploidy including microdeletions) -- Noninvasive prenatal diagnosis for single-gene disorders -- Invasive diagnostic procedures -- Prenatal diagnosis of chromosome abnormalities -- Advances in molecular genetics including fetal sequencing -- Expanded carrier screening -- Prenatal screening for thalassemias -- Sonography of the fetal central nervous system -- The heart -- Fetal lung lesions -- Congenital diaphragmatic hernia -- Abdomen -- Kidney and urinary tract disorders -- Diagnosis and management of fetal skeletal abnormalities -- Diagnosis and management of abnormalities of the face -- Fetal hydrops -- Fetal tumours -- Open fetal surgery -- Fetal growth and growth restriction -- Haemolytic disease of the fetus and newborn -- Fetal platelet disorders -- Fetal infections -- Disorders of amniotic fluid -- Multiple pregnancy -- In utero stem cell transplantation -- Fetal gene therapy -- The developmental origins of health and disease -- Pharmacokinetics and pharmacodynamics -- Neonatal management and outcome in extreme prematurity -- Self-assessment.

This book provides an overview of Fetal Medicine practice focusing on various aspects of fetal health such as screening for fetal aneuploidies and imaging for fetal anomalies, their basic management and technological breakthroughs.Although the field of Fetal Medicine is very wide, this book has condensed the important issues and is written in an " easy to read" format to simplify concepts for the readers. Fetal Medicine has emerged as a separate specialization and has an interdisciplinary appeal for clinicians. With the advent of knowledge and awareness in this field there are emerging challenges in counseling patients regarding available options. This book aims to be a ready reference for clinicians in Obstetrics and Radiology who encounter patients with fetal anomalies, growth disorders, multiple pregnancies and genetic /chromosomal problems. This is a highly informative and carefully presented book providing insights for clinicians with an interest in Fetal Medicine.

This book explores the recent clinical and research findings in the field of prenatal screening and diagnosis. It presents new devices and tests such as real-time 3D ultrasound, ultrafast fetal MRI, and next-generation sequencing and discusses genetic counseling and fetal therapy. Written by pioneering scientists, the book is divided into six themed parts: ultrasound examination, genetic tests, genetic disorders, chromosomal diseases, genetic counseling, and techniques, presenting carefully prepared original data.This thought-provoking, instructive and informative book is intended for geneticists, obstetricians, pediatricians, genetic counselors and nurses. Although the incidence of congenital abnormalities such as structural, chromosomal and genetic disorders is very low, it is important to have accurate information on their incidence and likely outcome, and on the screening and diagnosis of congenital abnormalities during pregnancy care. This book provides valuable insights into prenatal screening, genetic counseling and fetal diagnosis.

Updated by a team of internationally renowned experts, this book gives a thorough overview of fetal pathophysiology and an evidence base for in utero: both medical (non-invasive) and surgical treatments. Many topics are expanded to cover recent advances, including: stem cell transplantation; tissue scaffolding; minimally invasive approaches to 'open fetal surgery'; the etiology, prevention and treatment of preterm birth and PROM; the genetic etiologies of fetal disease; and gene therapy. In addition, there are in-depth discussions as to the role of open fetal myelomeningocele repair and several fetoscopic approaches to therapy. The international editors have added important new chapters on reducing stillbirth and prenatal counselling. This book is an invaluable reference guide to the latest fetal therapy options, and an essential, in-depth study book for maternal-fetal and neonatology specialists.

"Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs."Publisher's description

Fibroids are benign growths of the uterus. They are the most common tumours found in women (20-30% of women), usually in later reproductive years. This book covers evidence-based indications for treatment of uterine fibroids in gynecology, the management of fibroids in pregnancy, surgical treatments and outcomes, rare fibroid syndromes, and more.

Preface -- The Epidemiology and Prevalence of Fibromyalgia -- Fibromyalgia Diagnosis -- Etiology -- Prognosis -- Lifestyle Modification and Fibromyalgia -- Psychological Treatment for Fibromyalgia -- Medications -- Adjuvant Treatments for Fibromyalgia -- Utilizing Clinical Treatments with a Limited Evidence Base -- Treatment of Special Groups: Children, Pregnant, Elderly and Mentally-disabled -- Emerging Developments -- Nutrition.