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  • Book
    Marc Daëron, Falk Nimmerjahn, editors.
    Summary: This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

    Contents:
    The Old but New IgM Fc Receptor (Fc[mu]R)
    Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease
    Intracellular antibody immunity and the cytosolic Fc receptor TRIM21
    Computational modeling of the main signaling pathways involved in mast cell activation
    Calcium channels in FcR signaling
    Regulation of Fc[epsilon]RI signaling by lipid phosphatases
    Fc Receptors as Adaptive Immunoreceptors
    Glycosylation and Fc Receptors
    Antibodies as natural adjuvants
    IgA, IgA receptors and their anti-inflammatory properties
    Humanized mice to study FcgR function
    FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions
    Human FcR polymorphism and disease
    Bridging auto-antibodies and arthritis; the role of Fc Receptors
    The FcgR of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies
    FcgRIIB as a key determinant of agonistic antibody efficacy
    Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work
    Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G.
    Digital Access Springer 2014