BookDaolin Tang, editor.
Summary: This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research.
Contents:
Intro; Contents;
Chapter 1: Lipid Metabolism and Ferroptosis; 1.1 Introduction; 1.2 Lipids Are a Diverse Class of Molecules that Mediate Cellular Life and Death; 1.2.1 The Composition and Function of Lipids in Cell Membranes; 1.2.2 Lipid Peroxidation: A Balance Between Signaling and Survival; 1.3 Ferroptosis Is a Lipid-Dependent Form of Cell Death; 1.4 The Role of Lipids and Lipid Metabolism in Ferroptosis; 1.4.1 Lipid Signatures of Cells Undergoing Ferroptosis; 1.4.2 Specific PUFA-Modifying Enzymes Are Required for Ferroptosis 1.4.3 The Role of Other Lipids and Lipid Metabolic Enzymes in Ferroptosis1.5 Lipid Peroxidation: Mechanism, Location, and Consequences; 1.5.1 How Do LOOHs Form in Ferroptosis?; 1.5.1.1 The Role of Lipoxygenase Enzymes; 1.5.1.2 Evidence for Non-enzymatic Lipid Autoxidation; 1.5.2 Where Are LOOHs Localized in Ferroptosis?; 1.5.2.1 The Role of the Plasma Membrane; 1.5.2.2 The Role of Mitochondria; 1.5.2.3 The Role of the Lysosome; 1.5.2.4 The Role of the ER; 1.5.2.5 The Role of Lipid Droplets; 1.5.3 How Does Lipid Peroxidation Kill Cells? 1.5.3.1 The Effect of Lipid Peroxidation on Membrane Dynamics1.5.3.2 The Effect of Lipid Peroxidation on Membrane-Embedded Protein Function; 1.5.3.3 The Effect of LOOH Breakdown Products on Essential Cellular Processes; 1.6 Conclusions and Future Perspectives; References;
Chapter 2: Iron Metabolism and Ferroptosis; 2.1 Introduction; 2.2 Iron Metabolism in Circulation; 2.3 Iron Metabolism in Cells; 2.4 Excess Iron and Cancer; 2.5 Ferroptosis in Iron Excess; 2.6 Ferroptosis and Ferritinophagy; 2.7 Conclusion; References;
Chapter 3: Regulation and Function of Autophagy During Ferroptosis 3.1 Introduction3.2 The Core Autophagy Machinery; 3.2.1 The ULK1/2 Complex; 3.2.2 The PIK3C3 Complex; 3.2.3 The Ubiquitin-Like Conjugation Systems; 3.3 Role of Autophagy in Ferroptosis; 3.3.1 Ferritinophagy Promotes Iron Accumulation in Ferroptosis; 3.3.2 Lipophagy Promotes Lipid Peroxidation in Ferroptosis; 3.3.3 BECN1-Mediated Lipid Peroxidation and Iron Accumulation in Ferroptosis; 3.3.4 STAT3-Mediated Lysosomal Cell Death in Ferroptosis; 3.3.5 CMA-Mediated GPX4 Degradation in Ferroptosis; 3.3.6 Clockophagy-Mediated ARNTL Degradation in Ferroptosis 3.3.7 Autophagy Promotes DAMP Release in Ferroptosis3.4 Conclusions and Perspectives; References;
Chapter 4: Heat Shock Proteins: Endogenous Modulators of Ferroptosis; 4.1 Introduction; 4.2 Classification and Function of HSPs; 4.2.1 sHSPs; 4.2.2 HSP40; 4.2.3 HSP60; 4.2.4 HSP70; 4.2.5 HSP90; 4.2.6 HSP100; 4.3 The Core Mechanisms of Ferroptosis; 4.3.1 Iron Accumulation; 4.3.2 Lipid Peroxidation; 4.3.3 HSPs in Ferroptosis; 4.3.3.1 HSPB1; 4.3.3.2 HSPA5; 4.3.3.3 HSP90 and HSPA8; 4.4 Conclusions and Perspectives; References