Books

Summary: "A concise illustrated guide to operative techniques and medical management of liver transplantation for surgical trainees and practicing professionals"-- Provided by publisher.

Summary: In the past, liver resections and liver transplantations were performed by different surgical teams, with very little interplay between the two. However, the evolution toward more complex operations called for an increasingly intense interaction between these surgical techniques: split liver and living donor liver transplantation have become popular in the transplant community, utilizing the Coinaud segmental anatomy in a very sophisticated way, while portal and arterial resection and reconstruction have become indispensable methods for treating Klatskin tumors infiltrating the hepatic hilum. This book offers a complete overview of the connections between liver transplantation and hepatobiliary surgery. It focuses on ex situ techniques for resection of tumors at the suprahepatic confluence, with or without venous reconstruction, and on total vascular exclusion of the liver with the aid of a venovenous bypass that should be a surgical option for referral centers in hepatopancreatobiliary surgery. By taking into consideration the development of minimally invasive liver surgery, it will introduce readers to a variety of new perspectives such as: vascular exclusion techniques with or without extracorporeal circulation, hemodynamic implications and lessons learned from liver transplant surgery, and technical details on pediatric transplantation and its informative role in modern biliary tract surgery. .

Contents:
1 Introduction
2 Cross training and didactic interplay
3 Preoperatory assessment of comorbidities in liver transplantation and HBP surgery
4 Vascular exclusion
5 Cooling technique
6 Machine perfusions
7 Chirurgia Ex situ
8 Vascular reconstructions
9 Biliary reconstruction
10 LDLT
11 Pediatric LDLT
12 Left Split Liver
13 Right Split Liver
14 Full-left Full-righr Slit Liver Transplantation
15 Outflow liver obstruction
16 Small for Size Syndrome
17 Regeneration techniques
18 Combined cardiothoracic and abdominal approach
19 Portal thrombosis
20 Bridging and downstaging: the role of Minimally-invasive surgery
21 Robotic surgery in liver transplantation and resection
22 Other "bridge" therapies
23 General Surgery in Liver transplant recipient
24 Anesthesia and resuscitation: from transplantation to major HPB interventions
25 Multimodal treatments for liver metastatic NeuroEndocrine Tumors: from resection to transplantation. .

Summary: This book provides keys, descriptions and illustrations for about 850 species of liverworts and hornworts, in 148 genera and 47 families, of Colombia and Ecuador. The largest genera are Lejeunea (66 spp.), Plagiochila (65), Frullania (54), Radula (33), Metzgeria (33), Cololejeunea (32), Cheilolejeunea (30), Bazzania (26), Drepanolejeunea (25), Ceratolejeunea (18), Diplasiolejeunea (18), and Syzygiella (18). Species descriptions include brief morphological characterization and discussion with emphasis on characters for identification, world range as well as distribution and habitat in Colombia and Ecuador. Classes, orders, families and genera are also described and the main features for recognition of the genera are briefly discussed. The introduction includes chapters on history of exploration, diversity and endemism, and classification. A glossary, bibliography and index to scientific names are also provided.

Contents:
Introduction
Diversity and Endemism
Classification
Keys and Descriptions
Glossary.

Summary: The inadequate supply of organs in the United States and other countries continues to drive the reliance on living donor transplantation. Representatives of the transplant community convened for a meeting on living donation in an effort to provide guidelines to promote the welfare of living donors. The consensus statement that resulted from this meeting recommended that transplant centers retain an Independent Living Donor Advocate (ILDA) to focus on the best interest of the donor. Over a decade later, nearly every transplant center in the United States, performing living donor surgeries, has incorporated an ILDA into their living donor screening and/or evaluation process, however there are no guidelines with regard to the ILDA's qualifications, clinical practice, or how address ethical challenges.

Contents:
Part I: Living Donation: Chapter 1: The Medical Selection of Live Donors,- Chapter 2: Kidney Paired Donation Programs for Incompatible Living Kidney Donors and Recipients
Chapter 3: Living Donor Liver Transplantation
Chapter 4: Intestinal Transplantation from Living Donors
Chapter 5: Living Donor Lung Transplantation
Chapter 6: Live Donor Pancreas Transplantation
Part II: Living Donor Advocacy: Chapter 7: The History of Living Donor Advocacy in Living Donor Transplantation
Chapter 8: Findings from a National Survey of Living Donor Advocates
Chapter 9: The Independent Donor Advocate and the Independent Donor Advocate Team
Chapter 10: Clasification of Living Organ Donors
Chapter 11: Unrelated Donors
Chapter 12: Education of the Donor by the ILDA (Psychosocial Aspects)
Chapter 13: Components and Timing of the ILDA Evaluation
Chapter 14: Contraindications to Living Donation from an ILDA Perspective
Chapter 15: Management of Conflict Between the Independent Living Donor Advocate and the Transplant Team
Chapter 16: Story Behind the Story
Chapter 17: Living Donor Experience
Part III: Living Donor Ethics: Chapter 18: Informed Consent for Living Organ Donation
Chapter 19: Pressure and Coercion
Chapter 20: Financial Considerations
Chapter 21: Autonomy, Agency, and Responsibility: Ethical Concerns for Living Donor Advocates
Chapter 22: A Practical Guide: Role of the Independent Living Donor Advocate: Protect or Advocate or Is It Both/And?
Chapter 23: Racial Disparities in Kidney Transplant and Living Donation
Chapter 24: The Evolution of the Role of the Independent Living Donor Advocates: Recommendations for Practice Guidelines.

Summary: This book provides a guide to the principles and practice of living kidney donation. Concise and well-structured chapters discuss the ethics of living kidney donation, medical evaluation of kidney donors, donor nephrectomy surgery, and long-term outcomes of transplantation, along with broader medical issues related to cardiology, surgery, and anesthesia. Living Kidney Donation: A Practical Guide aims to give readers the essential information required for undertaking living kidney donation and is relevant to nephrologists, transplant surgeons, and healthcare professionals working in renal transplantation.

Contents:
1. Introduction
2. Living donor activity
3. Ethics of living kidney donation
4. Regulatory governance of living kidney donation
5. Novel use of living kidney donors
6. Barriers to living kidney donation
7. Medical evaluation of potential living kidney donors
8. Surgical assessment of potential living kidney donors
9. High-risk living kidney donors
10. Contra-indications to living kidney donation
11. Donor nephrectomy surgery
12. Peri- and post-operative care of living kidney donors
13. Post-donation haemodynamic consequences
14. Long-term outcomes
15. Strategies to increase living kidney donation
16. Summary and concluding chapter.

Summary: This book provides a complete guide to the evaluation, care, and follow-up of living kidney donors. Living donor kidney transplantation is established as the best treatment option for kidney failure. However, despite the tremendous benefits of living donation to recipients and society, the outcomes and optimal care of donors themselves have received relatively less attention. Fortunately, things are changing including recent landmark developments in living donor risk assessment, policy and guidance. This volume offers authoritative, evidence-based guidance on the full range of clinical scenarios encountered in the evaluation and care of living kidney donors. The approach to key elements of risk assessment, ethical considerations and informed consent is accompanied by recommendations for patient-centered care before, during, and after donation. Advocacy initiatives and policies to remove disincentives to donation and advance a defensible system of practice are also discussed. General and transplant nephrologists, as well as related allied health professionals, can look to this book as a comprehensive resource addressing contemporary clinical topics in the practice of living kidney donation.

Contents:
Rationale and Landscape of Living Kidney Donation in Contemporary Practice
Informed Consent & Framework of Living Donor Care
Evaluation of Renal Function, Albuminuria and Hematuria in Living Donor Candidates
Evaluation of Renal Anatomy, Structure and Nephrolithiasis in Living Donor Candidates
Evaluation of Hypertension in Living Donor Candidates
Evaluation of Metabolic and Cardiovascular Risks in Living Donor Candidates
Infection and Cancer Screening in Living Donor Candidates
Evaluation of Genetic Kidney Disease in Living Donor Candidates
Perioperative Evaluation and Management of Living Donor Candidates
Compatibility, Kidney Paired Donation, and Incompatible Living Donor Transplants
Psychosocial Evaluation, Care and Quality of Life in Living Kidney Donation
Risk Assessment Tools and Innovations in Living Kidney Donation
Living Donor Nephrectomy: Approaches, Outcomes and Innovations
Follow-up Care after Living Kidney Donation
Ethical and Policy Considerations in Living Donor Evaluation and Care
Living Donor Transplant Program Growth, Innovation and Sustainability.

Summary: Written by a practitioner with over 25 years of experience, Living Mindfully shows how mindfulness can be integrated with coaching in order to enhance motivation and achieve an authentic life. Combines mindfulness techniques designed to explore an individual's relationships to thoughts, values and emotions with coaching strategies that build self-confidence and motivation Details the Living Mindfully program and the practical coaching intervention, Training Individuals in Mindfulness and Excellence (TIME), with tips, exercises, further resources and client testimonials Discusses important aspects of mindfulness, including awareness, staying present, acceptance, authenticity, and dealing with negative beliefs and emotions Outlines the requirements for setting up and maintaining a mindfulness program for mindfulness teachers, coaches, counselors, policymakers, and government departments.

Contents:
Mindfulness
Living mindfully: a five-week programme
The art of orientation
The inquiry process
Moving out of automatic pilot and being more aware of our bodies
Being present in mindfulness of the breath and the body in movement
Staying present and dealing with difficult thoughts and emotions
Accepting and letting be
Bringing it together, looking after yourself, and moving forward
Integrating mindfulness and coaching
The TIME programme: development and rationale
Authenticity and its impact upon confidence and self-esteem
Acceptance: working with negative beliefs and emotions
Communication: releasing our words to the universe
Planning the way forward: an unfolding journey
In conclusion.

Summary: This book addresses current issues in the neuroscience and ethics of dementia care, including philosophical as well as ethical legal, and social issues (ELSIs), issues in clinical, institutional, and private care-giving, and international perspectives on dementia and care innovations. As such, it is a must-read for anyone interested in a well-researched, thought-provoking overview of current issues in dementia diagnosis, care, and social and legal policy. All contributions reflect the latest neuroscientific research on dementia, either broadly construed or in terms of the etiologies and symptoms of particular forms of dementia. Given its interdisciplinary and international scope, its depth of research, and its qualitative emphasis, the book represents a valuable addition to the available literature on neuroethics, gerontology, and neuroscientific memory research.

Summary: "This book focuses on the lobar anatomy of the breast and on the sick lobe concept - a novel theory of breast cancer development that is gaining ever wider acceptance - and explores their significance for innovative surgical treatment. Special attention is paid to the role of ductal echography, a technique capable of clearly depicting the structures of cancer in relation to the structures of the sick lobe. Having established a sound theoretical and practical basis through detailed coverage and correlation of anatomy, pathology, and imaging appearances, the book goes on to describe a revolutionary surgical approach particularly suitable for the treatment of multifocal and multicentric breast carcinomas. Such tumors account for more than a third of all cases of breast carcinoma and are often treated by mastectomy. The proposed new breast-conserving technique yields excellent cosmetic results and entails a very low risk of recurrence. The book will appeal to a wide readership, including radiologists, surgeons, oncologists, pathologists, as well as residents"--Back cover.

Summary: "This book is an important addition to the knowledge of lobster research. The book complements other books published on lobster research and management as it focuses on Indian lobster fisheries and aquaculture developments where there have been nearly 350 research papers and reports and 19 PhD awards. The book has 15 chapters written by international experts covering many aspects of the biology of a number of spiny and slipper lobster species occurring in India and world oceans with maps illustrating global distribution of spiny lobster families, genera and species. An updated taxonomy and checklist of marine lobsters, the status and management of lobster fisheries in India and Indian Ocean Rim countries and a review of aquaculture research in India and other major countries have also been presented. The book is timely as the 2nd International Indian Ocean Expedition (IIOE) is currently underway (2015-2020), 50 years after the original IIOE (1959-1965), with some of the original lobster research on the biology and distribution of phyllosoma larvae being undertaken on the plankton samples collected during the first IIOE. Many of the chapters are contributed by the authors from Central Marine Fisheries Research Institute (CMFRI), which has been collecting fishery and biological data on lobsters since 1950 when lobster fishing began on a subsistence scale, followed by some industrial fishing for lobsters in different parts of India. Unfortunately, the development of some of these lobster fisheries was followed by overfishing due to lack of enforcement of regulations. The book provides a valuable addition to our knowledge of the biology, fisheries and aquaculture of spiny and slipper lobsters."--Provided by publisher.

Contents:
Introduction, anatomy and life history
An updated checklist of World marine lobsters
Lobster fauna of India
Molecular phylogeny and taxonomic implications in spiny lobsters
Ecology and distribution of palinurid lobsters
Food, feeding behaviour, growth, reproduction and neuroendocrine control of moulting and reproduction
Lobster fisheries and Management : Part A. Spiny and slipper lobster fisheries in India. B. Lobster fisheries of Indian Ocean Rim Countries
Review of on the current global status and future challenges for management of lobster fisheries
Reproductive biology of spiny and slipper lobsters
Breeding, hatchery production and mariculture. A. Spiny lobsters. B. Slipper lobsters
Culture of Scyllarid lobster larvae fed jellyfish as food
Lobster aquaculture development in Vietnam and Indonesia
Pathogens and health management in lobster aquaculture
Postharvest processing, value addition and marketing of lobsters
Perspectives and future directions for lobster research.

Contents:
Flap classification
Bilobed flap
Rhomboid flap
Crescentic flap
Septal flap
Nasolabial flap
V to Y advancement flap
Keystone flap
Paramedian forehead flap
The temporoparietal fascia flap
Temporalis muscle flap
Cervicofacial advancement flap
Submental island flap
Pectoralis major myocutaneous flap
Latissimus dorsi myocutaneous flap
Sternocleidomastoid flap
Trapezius flap
The supraclavicular artery island flap
The internal mammary perforator flap
Ear reconstruction
Lip reconstruction
Nasal reconstruction
Scalp reconstruction.

Summary: This book, richly illustrated in full colour, is a comprehensive guide to the use of local anaesthesia in dentistry that will meet the needs of both students and dental practitioners. It provides the reader with ample background information on the origin of pain and the pharmacology of anaesthetics, and describes the anatomy of the trigeminal nerve in detail. Subsequent chapters cover key are as such as general practical aspects, local anaesthesia in the upper and the lower jaw, the use of local anaesthetics in children, local and systematic complications, and the prevention of side effects. Patients at particular risk of adverse effects are identified and attention drawn to significant legal aspects. This second edition has been completely revised, with more attention to safety, environment, and sterility. Additional injection techniques have been included, and a new chapter is devoted to microprocessor-assisted administration of anaesthetics. Throughout, care has been taken to ensure that the information is clearly presented and the text is easy to read.

Contents:
Pain and Impulse Conduction
Anatomy of the Trigeminal Nerve
Pharmacology of Local Anesthetics
General Practical Aspects
Local Anesthesia in the Upper Jaw
Local Anesthesia in the Lower Jaw
Additional Anesthetic Techniques
Microprocessor-Controlled Local Anesthesia
Local Anesthesia in Children
Local Complications
Systemic Complications
Patients at Risk
Legal Aspects.

Contents:
Local anaesthesia
Aesthetic & reconstructive units
Decision making process / defect assessment
Individual flaps
Reconstruction of specific sites.

Summary: This book presents a systematic survey of different local treatments in inflammatory joint diseases and their potential side effects and complications. Both surgical therapies and pharmaceutical strategies involving local or systemic application of anti-inflammatory and immunomodulating drugs are addressed. Special emphasis is placed on nuclear medicine therapy by intra-articular instillation of beta radiation emitters, known as radiosynoviorthesis or radiation synovectomy. Possible complications, in particular radionecrosis, infection, and thromboembolism, are described and available treatment strategies are examined in detail. In addition, radiation safety considerations are critically reviewed and relevant clinical questions are discussed. While radiosynoviorthesis is an effective and safe treatment if a proper indication is secured and if the application is performed by an experienced nuclear medicine physician, local complications can never be excluded with certainty. This book will support physicians who are engaged in the care and treatment of patients with inflammatory joint disease, approximately 30,000 of whom undergo radiosynoviorthesis in Europe each year. .

Contents:
Preface
Histopathology of synovitis
Non-radioactive treatment of synovitis (risk-benefit)
Introduction to radiosynoviorthesis (RSO)
Dosimetry and radiation burden
Local complications and possible treatment strategies
Risk of malignoma induction
Baker ́s cysts a relevant contraindication - Analysis of periodic update reports
Summary.

Summary: Focusing on local wound care specifically for the dermatologist, this concise text provides a go-to source for practitioners looking for a quick solution for many of the most common wounds as well as an update on what's new in the field. From the most basic principles of local wound care to a look at what upcoming therapies like stem cells and lasers can do, this text is comprehensive and informed. Providing quality local wound care requires an ample knowledge of available products, their cost effectiveness, and the principles for the optimal interventions; Local Wound Care for Dermatologists includes these three guiding points in each chapter that focuses on a specific therapy. Expertly written text is accompanied by multiple tables of drug-specific names, current price points, and comparable products. Chapters include many color images, thereby providing insight to a given wound and the various therapies available to treat it. While the basics are reviewed in the opening chapters, later chapters feature updates in therapies including discussions on what's new in skin substitutes, negative pressure wound therapy, oxygen therapy, and an update in cell based therapy. Written with the dermatologist in mind, Local Wound Care for Dermatologists is an indispensable reference for students, residents, and practicing doctors alike. General practitioners and plastic surgeons will also find this title a useful refresher.

Contents:
1. The Basic Principles in Local Wound Care
2. Skin pH, Epidermal Barrier Function, Cleansers, and Skin Health
3. Chronic Wounds and Infections
4. Wound Dressings
5. The Use of Antiseptic and Antibacterial Agents on Wounds and the Skin
6. Topical Anti-inflammatory Agents in Wound Care
7. Wound Dressing Allergic Contact Dermatitis: Epidemiology and Management
8. Vascular Studies for Nonvascular Surgeons
9. Compression Therapy
10. Management of Diabetic Foot Ulcers: Offloading and Debridement
11. Negative Pressure Wound Therapy
12. Oxygen Therapy in Wound Healing
13. The Role of Ablative Fractional Lasers in Wound Healing
14. Stem Cell Therapy in Wound Care
15. Cellular- and Acellular-Based Therapies: Skin Substitutes and Matrices
16. Local Peristomal Cutaneous Manifestations and Their Management
17. Comprehensive Wound Care for Malignant Wounds
18. Wound Healing in Hidradenitis Suppurativa
19. Wound Healing in Pyoderma Gangrenosum
20. Scar Management.

Contents:
General principles of neurologic localization
Peripheral nerves
Cervical, brachial, and lumbosacral plexi
Spinal nerve and root
Spinal cord
Cranial nerve I (the olfactory nerve)
Visual pathways
The localization of lesions affecting the ocular motor system
Cranial nerve V (the trigeminal nerve)
Cranial nerve VII (the facial nerve)
Cranial nerve VIII (the vestibulocochlear nerve)
Cranial nerves IX and X (the glossopharyngeal and vagus nerves)
Cranial nerve XI (the spinal accessory nerve)
Cranial nerve XII (the hypoglossal nerve)
Brainstem
The cerebellum
The localization of lesions affecting the hypothalamus and pituitary gland
The anatomic localization of lesions in the thalamus
Basal ganglia
The localization of lesions affecting the cerebral hemispheres
Localization of lesions in the autonomic nervous system
Vascular syndromes of the forebrain, brainstem, and cerebellum
The localization of lesions causing coma.

Contents:
General principles of neurologic localization
Peripheral nerves
Cervical, brachial, and lumbosacral plexuses
Spinal nerve and root
Spinal cord
Cranial nerve I (the olfactory nerve)
Visual pathways
The localization of lesions affecting the ocular motor system
Cranial nerve V (the trigeminal nerve)
Cranial nerve VII (the facial nerve)
Cranial nerve VIII (the vestibulocochlear nerve)
Cranial nerves IX and X (the glossopharyngeal and vagus nerves)
Cranial nerve XI (the spinal accessory nerve)
Cranial nerve XII (the hypoglossal nerve)
Brainstem
The cerebellum
The localization of lesions affecting the hypothalamus and pituitary gland
The anatomic localization of lesions in the thalamus
Basal ganglia
The localization of lesions affecting the cerebral hemispheres
Localization of lesions in the autonomic nervous system
Vascular syndromes of the forebrain, brainstem, and cerebellum
The localization of lesions causing coma.

Summary: This book is an attempt to advance the discussion and improve our understanding about the effects of aging and movement disorders on motor control during walking and postural tasks. Despite these activities are performed daily, there is a high requirement of motor and neural systems in order to perform both tasks efficiently. Both walking and posture require a complex interaction of musculoskeletal and neural systems. However, the mechanisms used to control these tasks, as well as how they are planned and coordinated, are still a question of discussion among health professionals and researchers. In addition, this discussion is more interesting when the effects of aging are included in the context of locomotion and the postural control. The number of older individuals is 841 million in 2015, which is four times higher than the 202 million that lived in 1950. Aging causes many motor, sensorial and neural deficits, which impair locomotion and postural control in the elderly. The severity of this framework is worsened when the aging goes along with a movement disorder, such as Parkinson disease, Chorea, Dystonia, Huntington disease, etc. Therefore, the aim of this book is to highlight the influence of different aspects on planning, controlling and performing locomotion and posture tasks. In attempting to improve current knowledge in this field, invited authors present and discuss how environmental, sensorial, motor, cognitive and individual aspects influence the planning and performance of locomotor and postural activities. The major thrust of the book is to address the mechanisms involved in controlling and planning motor action in neurological healthy individuals, as well as in those who suffer from movement disorders or face the effects of aging, indicating the aspects that impair locomotion and postural control. In addition, new technologies, tools and interventions designed to manage the effects of aging and movement disorders are presented in the book.

Contents:
Part I. Background concepts to motor control in aging and movement disorders
Part II. Walking
Part III. Posture
Part IV. Technology and rehabilitation applied to locomotion and posture.3

Summary: This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.

Contents:
Human Cancer- Epidemiology, Hallmarks, and Defense Strategies
Cancer Treatment Modalities Systemic and Loco regional Approaches: Challenges and Opportunities of multidisciplinary approaches
Cancer Radiotherapy: General Considerations and Human Radiobiology
Radionuclide Cancer Therapy- Unsealed Alpha, Beta and Gamma Emitters
Locoregional Therapy - Cancer Interventions with and without Radionuclides
Radiation Dosimetry Considerations of Locoregional Radionuclide Cancer Therapy
Voxel-based Targeted Radionuclide Therapy Dosimetry
Locoregional Unsealed Radionuclide Cancer Therapy - Experimental Findings
Animal Cancer Therapy Models - Ready Translation to Humans
An Overview of Regulations of Radiopharmaceuticals
Locoregional Radionuclide Cancer Therapy (LRCT) Using Sealed & Unsealed Radionuclides.

Contents:
Basics of Regional Tumor therapies: Locoregional Tumor Therapies, Evidence and Future
Pharmacokinetic of Locoregional Tumor Therapies
Embolization Materials, Catheter, IA-port systems Indications for locoregional tumor therapies ? Liver: HCC
Liver Metastases of CRC- Liver Metastases of Neuroendocrine Tumors and CCC
Liver metastases of other indications: Pancreas Carcinoma
Melanoma
Breast Carcinoma. Indications for locoregional tumortherapies ? Lung: Basics
Primary Lung Tumors
Lung metastases Thermoablation: Liver
Lung. Head and Neck.

Summary: "Informed by research during the past half-century, the World Health Organization and other national health and health care bodies have increasingly emphasized the impact of social determinants of health on major health outcomes, including quality of life and longevity. One risk factor that has become increasingly prominent is loneliness-a subjective feeling of distress due to perceived social isolation. Loneliness has been shown to have major adverse mental and physical health effects throughout the life span. Loneliness: Science and Practice is, in part, a response to the National Academies of Science, Engineering and Medicine report released in early 2020 that called for screening for loneliness and social isolation in all health care practices and a need to develop best practices for addressing social isolation and loneliness in all medical subspecialty settings. As the COVID-19 pandemic and physical-distancing measures emerged in 2020, the need for the dissemination of knowledge of loneliness became even more pressing. This book reviews the important and growing literature on loneliness, focusing on evidence-based findings. It addresses both the science and the everyday practice of mental health care that involves the psychobiology of loneliness, its appropriate clinical assessment, and strategies to prevent and manage its adverse consequences"-- Provided by publisher.

Contents:
Loneliness, other aspects of social connection, and their measurement / Nancy J. Donovan, Julianne Holt-Lunstad
Loneliness across the life span / Maike Luhmann, Louise Hawkley, Susanne Bücker, Tilmann von Soest, Jürgen Margraf
Loneliness in people living with mental health disorders / Miya Gentry, Barton W. Palmer
Loneliness in marginalized communities / Lize Tibiriçá, Dylan J. Jester, Barton W. Palmer, Dilip V. Jeste
Neurobiology of loneliness / Jeffrey A. Lam, Ellen E. Lee
Systemic neuroendocrine and inflammatory mechanisms in loneliness / Kelly E. Rentscher, Steve W. Cole, Judith E. Carroll
Interventions for loneliness in younger people / Pamela Qualter, Alice Eccles, Manuela Barreto
Interventions for loneliness in older adults / Kimberly A. Van Orden, Yeates Conwell
Community-based interventions for loneliness / Phaedra Bell, Brian Lawlor.

Contents:
Non-coding RNAs: New Players in Cancers
The Working Modules of Long Non-coding RNAs in Cancer Cells
Methods to Study Long Non-coding RNA Biology in Cancer
Relationship between Non-coding RNA Dysregulation and Epigenetic Mechanisms in Cancer
Non-coding RNAs in Growth and Death of Cancer Cells
Non-coding RNAs in Cancer Cell Plasticity
Non-coding RNAs in Regulation of Cancer Metabolic Reprogramming
Non-coding RNAs in Tumor Angiogenesis
Non-coding RNAs in Cancer Immunity
Non-coding RNAs in Therapeutic Resistance of Cancer
Non-coding RNAs Regulating Cancer Signaling Network
Non-coding RNAs Regulating NFkB Signaling
Non-coding RNAs Regulating p53 and c-Myc Signaling
Viral Non-coding RNAs in Cancer Biology
Non-coding RNAs in Cancer Diagnosis
Therapeutic Potentials of Non-coding RNAs: Targeted Delivery of NcRNAs in Cancer Cells.

Summary: The dark side of the genome represents vast domains of the genome that are not encoding for proteins - the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNAIt presents the broad functional diversities of those moleculesIt presents pioneer works from the fieldProvides a comprehensive review of the field Presents fundamental and therapeutic interests

Contents:
Foreword: The modern RNA world
Preface
1. Non-coding RNA, its history and discovery timeline
2. Definition and families of long non-coding RNA
3. Biological functions of long non-coding RNA
4. Non-coding RNA in development
5. Long non-coding RNA and cancer
Concluding perspectives
Bibliography
Glossary
List of acronyms
Index.

Summary: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Contents:
1. History, discovery, and classification of IncRNAs
2. Long noncoding RNA: genome organization and mechanism of action
3. From heterochromatin to long noncoding RNAs in Drosophila: expanding the arena of gene function and regulation
4. Long noncoding RNAs in the Yeast S. cerevisiae
5. Long noncoding RNAs in plants
6. Long noncoding RNAs in mammalian development and diseases
7. Long noncoding RNAs in cancer and therapeutic potential
8. Long noncoding RNAs in pluripotency of stem cells and cell fate specification
9. Understanding the role of IncRNAs in nervous system development
10. Technological developments in IncRNA biology.

Contents:
Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its Implications in Disease Conditions
Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease
Form and function of exosome associated long non-coding RNAs in cancer
Long Non-coding RNAs in Lung Cancer
Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease
Functional long non-coding RNAs in vascular smooth muscle cells
Long Non-coding RNAs as Targets and Regulators of Nuclear Hormone Receptors
Non-coding transcriptional landscape in human aging
LncRNAs in stress response
Expression Specificity of Disease-Associated lncRNAs: towards Personalized Medicine. .

Summary: This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.

Contents:
Section 1: Overview
Chapter 1: Introduction and overview
Section 2: Basics of long noncoding RNA Classifications and functions
Chapter 2: The Complexity of the Mammalian Transcriptome
Chapter 3: Towards molecular mechanism in long non-coding RNAs: linking structure and function
Section 3: Long noncoding RNA and inflammation
Chapter 4: Long noncoding RNAs in Rheumatology
Chapter 5: LncRNA and Cardiovascular Disease
Chapter 6: A role for lncRNAs in regulating inflammatory and autoimmune responses underlying type 1 diabetes
Section 4: Long noncoding RNAs as Therapeutic targets
Chapter 7: LncRNA Biomarkers of Inflammation and Cancer
Chapter 8: Functional Implications of Intergenic GWAS SNPs in Immune Related lncRNAs
Chapter 9: Long noncoding RNAs as Therapeutic Targets
Section 5: Challenges and Future Directions
Chapter 10: Challenges and future directions for LncRNAs and inflammation.

Summary: "In February 2023, CMS issued revisions to Phase 3 of The Long Term Care Survey, which are included in AHCA’s newly updated Long Term Care Survey, Phase 3. Changes to the new version of the manual include: List of Revised F-TAGS, which was not part of CMS’s advanced copy release in 2022; Updates and Links to Exhibits of Survey Forms; Updates and Corrections to Appendix PP State Operations Manual – Guidance to Surveyors for LTC Facilities (includes revision number, issue date, effective date, and implementation date); Updates to the State Operations Manual, Chapter 7: Survey and Enforcement Process for Skilled Nursing Facilities and Nursing Facilities; Updates to the Long Term Care Survey Process (LTCSP) Procedure Guide." -- Publisher's website.

Summary: This open access book presents and analyzes the results of more than 30 years of long-term ecological research in riparian forest ecosystems with the aim of casting light on changes in the dynamics of riparian forests over time. The research, focusing on the Ooyamazawa riparian forest, one of the remaining old-growth forests in Japan, has yielded a number of interesting outcomes. First, it shows that large-scale disturbances afford various trees opportunities for regeneration and are thus the driving force for the coexistence of canopy trees in riparian forests. Second, it identifies changes in reproductive patterns, highlighting that seed production has in fact quantitatively increased over the past two decades. Third, it describes the decline in forest floor vegetation caused by deer grazing and reveals how this decline has affected bird and insect populations. The book illustrates the interconnectedness of phenomena within an ecosystem and the resultant potential for cascade effects and also stresses the need for long-term ecological studies of climate change impacts on forests. It will be of interest to both professionals and academics in the field of forest science.

Contents:
Part I. Introduction
Chapter 1. The Ooyamazawa Riparian Forest: Introduction and Overview
Part II. Life History and Regeneration Processes of Riparian Woody Species.-Chapter 2. Fraxinus platypoda
Chapter 3. Pterocarya rhoifolia
Chapter 4. Cercidiphyllum japonicum
Chapter 5. Acer Tree Species
Part III. Diversity and Coexistence in Riparian Forests
Chapter 6. Diversity of Herbaceous Plants in the Ooyamazawa Riparian Forest
Chapter 7. Coexistence of Tree Canopy Species
Part IV. Ecosystem Changes in Riparian Forests
Chapter 8. Changes in Forest Floor Vegetation
Chapter 9. Temporal Changes in Browsing Damage by Sika Deer in a Natural Riparian Forest in Central Japan
Chapter 10. Characteristics and Temporal Trends of a Ground Beetle (Coleoptera: Carabidae) Community in Ooyamazawa Riparian Forest
Chapter 11. Avifauna at Ooyamazawa: Decline of Birds that Forage in Bushy Understories
Part V. Conclusion
Chapter 12. General Conclusion.

Summary: This book provides an overview of forensic psychiatry, focusing on the provision of care in Europe as well as the legal and ethical challenges posed by long-term stays in forensic settings. Forensic psychiatric services provide care and treatment for mentally disordered offenders (MDOs) in secure in-patient facilities as well as in the community. These services are high-cost/low-volume services; they pose significant restrictions on patients and hence raise considerable ethical challenges. There is no agreed-upon standard for length of stay (LoS) in secure settings and patients detainment periods vary considerably across countries and even within the same jurisdiction. Thus far, little research has been conducted to identify factors associated with length of stay; consequently, it remains unclear how services should be configured to meet the needs of this patient group. This volume fills some of those gaps. Furthermore, it presents new research on factors associated with length of stay, both patient-related and organisational. Various approaches to the provision of care for long-term patients in different countries are explored, including a few best practise examples in this specific area of psychiatry. The book also addresses the perspective of those working in forensic care by reviewing quality-of-life research and interviews with patients. The authors of this volume come from a range of professional backgrounds, ensuring a certain breadth and depth in the topic discussion, and even includes patients themselves as (co-)authors.

Contents:
Why a Volume on Long-Term Outcomes of Epilepsy Surgery?
Methodological Demands on Observational Studies of Outcomes After Epilepsy Surgery
Long-Term Seizure and Antiepileptic Drug Outcomes After Epilepsy Surgery in Adults
Long-Term Seizure and Antiepileptic Drug Outcomes After Epilepsy Surgery in Children
Long-Term Cognitive Outcomes After Epilepsy Surgery in Adults
Long-term Cognitive Outcomes After Epilepsy Surgery in Children
Long-Term Psychiatric Outcomes After Epilepsy Surgery in Adults
Long-Term Psychiatric and Behaviour Outcomes in Children Following Epilepsy Surgery
Mortality After Epilepsy Surgery
Long-Term Educational and Vocational Outcomes of Adults After Epilepsy Surgery
Educational and Employment Outcomes Following Epilepsy Surgery in Childhood
Quality of Life Outcomes in Adults Following Epilepsy Surgery
Quality of Life and Psychosocial Outcomes in Children Following Epilepsy Surgery
Subjective Experiences of Epilepsy Surgery in Adults
Subjective Experiences of Children and Parents After Epilepsy Surgery
Informed Consent for Epilepsy Surgery
Managing Expectations of Epilepsy Surgery
Health Economic Analyses of Epilepsy Surgery
Long-Term Outcomes of Epilepsy Surgery: Knowledge Gaps and Future Directions. .

Contents:
Key concepts
Assessment, indications, and formulation
The nuts and bolts of psychotherapy : getting started
Therapeutic interventions : what does the therapist say and do?
Goals and therapeutic action
Working with resistance
Use of dreams and fantasies in dynamic psychotherapy
Identifying and working with countertransference
Working through and termination
Use of supervision
Evaluating core competencies in long-term psychodynamic psychotherapy.

Summary: The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Contents:
Evolutionary Genetic Bases of Longevity and Senescence
Candidate Genes That Affect Aging Through Protein Homeostasis
Autophagy and Aging
A Genetic View of the Mitochondrial Role in Aging: Killing Us Softly
GWAS and Meta-analysis in Aging/Longevity
Exome and Whole Genome Sequencing in Aging and Longevity
Models to Explore Genetics of Human Aging
Systems Biology of Aging
Epigenetics of Aging.

Summary: This book is an unique but practical case-driven guide to a variety of pediatric dermatology diseases observed over long periods. It features a broad range of cases covering initial presentation during infancy and the subsequent developments of through childhood, adolescence and adulthood. Disease cases include papulosquamous disorder, hereditary cornification, exanthematous diseases and viral infections of the skin.

Contents:
Cutaneous disorders of newborn
Eczematous eruptions of childhood
Papulosquamous disorders
Hereditary disorders of cornification
Hereditary disorders of the dermis
Disorders of the hair and nails
Disorders of sebaceous and sweat glands
Cutaneous tumors and tumor syndromes
Histiocytoses and malignant skin disease
Disorders of pigmentation
Vascular disorders of infancy and childhood
Bullous disorders of childhood
Bacterial, mycobacterial, protozoal, and viral infections of the skin
Exanthematous diseases of childhood
Skin disorders caused by fungi
Photosensitivity and photoreactions
Hypersensitivity syndromes
Vasculitic disorders
Collagen vascular disorders
Endocrine disorders and the skin
Inborn error of metabolism
Skin signs of systemic diseases
Abuse and factitial disorders.

Contents:
Unit 1: principles of dermatology. Introduction
Structure and function of the skin
Principles of diagnosis
Dermatologic therapy and procedures
Unit 2: growths. Epidermal growths
Pigmented growths
Dermal and subcutaneous growths
Unit 3: rashes with epidermal involvement. Eczematous rashes
Scaling papules, plaques, and patches
Vesicles and bullae
Inflammatory papules
Pustules
White spots
Unit 4: dermal rashes. Generalized erythema
Localized erythema
Specialized erythema
Purpura
Dermal induration
Unit 5: Ulcers. Ulcers
Unit 6: Hair and nails. Hair disorders
Nail disorders
Unit 7: Mucous membrane disorders. Mucous membrane disorders
Unit 8: Diagnosis by symptom. Skin signs of systemic disease
Self-assessment.

Summary: This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses.

Contents:
I. Barriers to incentives for translational research
II. Integrating emerging science into clinical practice
III. Organization, prioritization, review and funding for the translational research
IV. Translational sciences in cancer research
V. Translational science in infectious diseases
VI. Translational research in endocrinology and nutrition
VII. Translation research and neuroscience
VIII. Stem cells and translational research
IX. The role of translational research in public health and behavioral sciences
X. Translational epidemiology, biostatistics and informatics
XI. Translational research outcomes and resources.

Summary: "In the city of Houston - a sprawling, diverse microcosm of America - the son of a black mother and a Latino father is coming of age. He's working at his family's restaurant, weathering his brother's blows, resenting his older sister's absence. And discovering he likes boys. Around him, others live and thrive and die in Houston's myriad neighborhoods: a young woman whose affair detonates across an apartment complex, a ragtag baseball team, a group of young hustlers, hurricane survivors, a local drug dealer who takes a Guatemalan teen under his wing, a reluctant chupacabra. Bryan Washington's brilliant, viscerally drawn world vibrates with energy, wit, and the infinite longing of people searching for home. With soulful insight into what makes a community, a family, and a life, Lot explores trust and love in all its unsparing and unsteady forms."--Inside dust jacket.

Contents:
Lockwood
Alief
610 North, 610 West
Shepherd
Wayside
Bayou
Lot
South Congress
Navigation
Peggy Park
Fannin
Waugh
Elgin.

Contents:
Beginnings
Christ's Hospital and Hal's early schooldays
Moving up the School
Science at Housey
A Cambridge undergraduate
Nuclear Physics and Professor Rutherford
Hal, a postgraduate member of Trinity College
Social life and marriage
Travel
The Mount Vernon Hospital
At the RRU and Hal's forced resignation
Hal, Director of his own Laboratory
The Stroke
Hal's passing. .

Contents:
Volume 1:
Embryology and development of the musculoskeletal system
Genetic aspects of orthopaedic conditions
Imaging in pediatric orthopaedics
The pediatric orthopaedic examination
Pain management
Metabolic and endocrine abnormalities
The skeletal dysplasias
Syndromes of orthopaedic importance
Localized disorders of skin and soft tissue
Diseases of the hematopoietic system
Juvenile idiopathic arthritis
Musculoskeletal infection
Bone and soft tissue tumors
Cerebral palsy
Other neurouscular disorders
Idiopathic scoliosis
Early-onset spine deformities
Adolescent kyphosis
Spondylolysis and spondylolisthesis
The cervical spine
Volume 2:
The upper limb
Developmental hip dysplasia and dislocation
Legg-Calvé-Perthes disease and other conditions of the hip
Slipped captical femoral epiphysis
The adolescent hip
The lower extremity
Limb-length discrepancy
The foot
The child with a limb deficiency
Sports medicine in the growing child
The principles of pediatric fracture and trauma care
Upper extremity fractures
Pediatric thoracolumbar spine and lower extremity fractures.

Summary: "Now in its updated Seventh Edition, Lovell and Winter's Pediatric Orthopaedics remains a must-have for physicians and residents treating infants, children, and adolescents with orthopaedic problems. This classic, comprehensive reference covers the basic science, clinical manifestations, and management of orthopaedic problems in children. Now in full color, the foremost orthopaedists examine normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection. The clinical chapters include pearls and pitfalls and a description of the author's preferred approach. The book will now cover surgical techniques of management with step-by-step illustrations from the Atlas of Pediatric Orthopaedic Surgery."-- Provided by publisher.

Contents:
V. 1: Embryology and development of the neuromuscular apparatus
Genetic aspects of orthopaedic conditions
Imaging in pediatric orthopaedics
The pediatric orthopaedic examination
Evaluation of the medical literature
Metabolic and endocrine abnormalities
The skeletal dysplasias
Syndromes of orthopaedic importance
Localized disorders of skin and soft tissue
Diseases of the hematopoietic system
Juvenile idiopathic arthritis
Musculoskeletal infection
Bone and soft-tissue tumors
Cerebral palsy
Myelomeningocele
Other neuromuscular disorders
Idiopathic scoliosis
Congenital scoliosis
Kyphosis
Spondylolysis and spondylolistesis
The cervical spine
V. 2: The upper limb
Developmental hip dysplasia
Legg-Calvâe-Perthes syndrome
Slipped capital femoral epiphysis
Other conditions of the hip
The lower extremity
Limb-length discrepancy
The foot
The child with a limb deficiency
Sports medicine in the growing child
The principles of pediatric fracture and trauma care
Upper extremity fractures in children
Thoracolumbar spine and lower extremity fractures.

Summary: "With this unflinching account, Justice Ketanji Brown Jackson invites readers into her life and world, tracing her family's ascent from segregation to her confirmation on America's highest court within the span of one generation. Named 'Ketanji Onyika,' meaning 'Lovely One,' based on a suggestion from her aunt, a Peace Corps worker stationed in West Africa, Justice Jackson learned from her educator parents to take pride in her heritage since birth. She describes her resolve as a young girl to honor this legacy and realize her dreams: from hearing stories of her grandparents and parents breaking barriers in the segregated South, to honing her voice in high school as an oratory champion and student body president, to graduating magna cum laude from Harvard, where she performed in musical theater and improv and participated in pivotal student organizations. Here, Justice Jackson pulls back the curtain, marrying the public record of her life with what is less known. She reveals what it takes to advance in the legal profession when most people in power don't look like you, and to reconcile a demanding career with the joys and sacrifices of marriage and motherhood. Through trials and triumphs, Justice Jackson's journey will resonate with dreamers everywhere, especially those who nourish outsized ambitions and refuse to be turned aside. This moving, openhearted tale will spread hope for a more just world, for generations to come"-- Provided by publisher.

Contents:
Preface: A sacred trust
Part one: Bringing the gifts. The dream
Black studies
No place like home
The deep end
Warrior hearts
Mighty spirit striving
Force of nature
The secret
Beloved community
In circle square
Our people
A more perfect union
Love changes everything
In full sail
Part two: Grit and grace. A year like no other
African homecoming
The culture of big law
What is justice?
Call of duty
Parenthood
The bench
Life support
From Leila's lips (to God's ears)
America the beautiful
We are the dream
Epilogue: Lovely life
Acknowledgments
Notes
Photograph credits.

Summary: "Warren Duffy has returned to America for all the worst reasons: his marriage to a beautiful Welsh woman has come apart; his comic shop in Cardiff has failed; and his Irish-American father has died, bequeathing to Warren his last possession, a roofless, half-renovated mansion in the heart of black Philadelphia. On his first night in his new home, Warren spies two figures in the grass outside; when he screws up the nerve to confront them, they disappear. The next day he encounters ghosts of a different kind: in the face of the teenage girl he meets at a comics convention he sees the mingled features of his white father and his black mother, both now dead. The girl is his daughter and she thinks she's white. Warren sets off to remake his life with a reluctant daughter he never knew and a haunted house and history he knows too well. In their search for a new life they struggle with an unwanted house and its ghosts, fall in with a utopian mixed-race cult, and inspire a riot on Loving Day, the unsung holiday that celebrates interracial love"--Publisher.

Summary: This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.

Contents:
Part 1. The Environmental Pollution Caused by the Fukushima Daiichi Nuclear Power Plant (FNPP) Accident
1. Estimation of Dose Rate for the Large Japanese Field Mice (Apodemus speciosus) Distributed in the "Difficult-to-Return Zones" in Fukushima Prefecture
2. Impacts of the Fukushima Nuclear Accident on Fishery Products and Fishing Industry
3. Incorporation and Accumulation of Strontium-90 in the Hard Tissue of Animals and Their Relationship with Strontium-90 Pollution in the Environment
Part 2. Radiation Exposure and Its Effects on Wild Organisms after the FNPP Accident
4. Radioactive Cesium Contamination of Arthropods and Earthworms after the FNPP accident
5. Delayed Recovery from Declines in the Population Densities and Species Richness of Intertidal Invertebrates near the Fukushima Daiichi Nuclear Power Plant
6. Mutations observed in mitochondrial DNA of salmon collected in Mano River, Fukushima Prefecture, Japan
7. Influence of the FNPP Accident on Coniferous Trees: A Review
Part 3. Radiation Exposure and Its Effects on Livestock after the FNPP Accident
8. Analysis of Ovaries and Fertilities in Domestic Animals affected by the Fukushima Daiichi Nuclear Power Plant Accident
9. Transgenerational Effects on Calf Spermatogenesis and Metabolome Associated with Paternal Exposure to the FNPP Accident
10. The Effect of Radiation on the Immune System in Pigs Affected by the Fukushima Daiichi Nuclear Power Plant Accident
11. Assessment of DNA Damage Induction in Farm Animals after the Fukushima Daiichi Nuclear Power Plant Accident
Part 4. Dose Evaluation in Association with the FNPP Accident
12. Preliminary Study on Electron Spin Resonance Dosimetry Using Affected Cattle's Teeth due to the Fukushima Daiichi Nuclear Power Plant Accident
13. Estimation of External and Internal Exposure in Japanese Macaques after the Fukushima Daiichi Nuclear Power Plant Accident
Part 5. New Perspectives Raised after the FNPP Accident
14. Properties of Radioactive Cs-bearing Particles Released by the Fukushima Daiichi Nuclear Power Plant Accident and Trace Element Analysis
15. Cellular Effects of Insoluble Particles Containing Radioactive Cesium
16. Preparation and Genome Analysis of Immortalized Cells Derived from Wild Macaques Affected by the Fukushima Daiichi Nuclear Power Plant Accident
17. Effects of Radioactive Cesium-containing Water on Mice
Prt 6. Overview of the FNPP accident
18. Comparison of Radioactivity Release and Contamination from the Fukushima and Chernobyl Nuclear Power Plant Accidents
19. The Pale Grass Blue Butterfly as an Indicator for the Biological Effect of the Fukushima Daiichi Nuclear Power Plant Accident
20. What We Learned and are Learning from the Affected Animal Dose Assessment Project. .

Summary: Global climate change requires the development of programs that consider the active restoration of degraded forests and the use of native trees in afforestation to preserve the natural environment. International commitments like the UN REDD program, the Montréal Process and the Convention on Biological Diversity call for the breeding of species rarely contemplated by large industrial companies. Low-intensity breeding is the most rational strategy for those species: simple but robust, and not dependent on continuously increasing funding, and therefore effective even with a relatively small budget. It commonly focuses on high genetic diversity rather than improving economic traits and adaptability rather than productivity. Controlled crosses with full pedigrees typical of high-intensity breeding are replaced by open pollination. This book presents state-of-the-art breeding strategies from the last two decades for several forest tree species of prime importance in the natural forests of Argentina. They are distributed in the three main forestry ecoregions of the country: the subtropical dry forest (Chaco), the subtropical rain forests (Yungas and Alto Paraná rainforests) and the temperate forests of Patagonia. The book also discusses the genetic patterns of the selected species defined using genetic markers together with the analysis of the variation in quantitative traits. Further, it examines the crucial features of their reproductive biology, such as the mating system and gene flow and describes the current breeding programs. Lastly, it presents the latest developments in genetic resources and their emerging applications, concluding with some reflections and perspectives related to the conditioning imposed by climate change.

Contents:
Chapter 1
Native forests claim for breeding in Argentina: general concepts and their state
Section I
Temperate Subantarctic Forests Chapter 2
Temperate Subantarctic Forests: a huge natural laboratory
Chapter 3
Raulí (Nothofagus alpina = N. nervosa): the best quality hardwood in Patagonia
Chapter 4
Roble pellín (Nothofagus obliqua): a southern beech with a restricted distribution area in Argentina but a wide environmental range
Chapter 5
Nothofagus Mixed Forest: a breeding program for an interspecific hybridization system
Chapter 6
Patterns of genetic variation of lenga (Nothofagus pumilio) and ñire (Nothofagus antarctica): the most widely distributed and cold tolerant southern beeches in Patagonia
Chapter 7
Patagonian Cypres (Austrocedrus chilensis): the cedarwood of the emblematic architecture of North Patagonia
Chapter 8
Other species pf high ecological value
Section II
Subtropical Dry Forests
Chapter 9
Subtropical dry forests: the main forest ecoregion of Argentina
Chapter 10
Genetic variation patterns of algarrobos (Prosopis sp.) from "Gran Chaco Americano" (P. alba, P. nigra, P. hassleri, P. chilensis and P. flexuosa)
Chapter 11
Genetic breeding of Prosopis species from "Gran Chaco Americano" Chapter 12
Species without current breeding relevance but high economic value
Section III
Subtropical Rainforests
Chapter 13
Subtropical rainforests: the Yungas and the Paranaense Rainforest
Chapter 14
Patterns of neutral genetic variation for three high-value cedar species from the Subtropical Rainforests of Argentina
Chapter 15
Breeding strategy for the Cedrela genus in Argentina
Chapter 16
Pino Paraná (Araucaria angustifolia): the most planted native forest tree species in Argentina
Chapter 17
Peteribí (Cordia trichotoma), Lapacho (Handroanthus impetiginosus) and Cebil (Anadenanthera colubrina var. cebil): three valuable species with incipient breeding programs
Section IV
Other species, new tools and final considerations
Chapter 18
Applications of High-Throughput Sequencing technologies on native forest tree species of Argentina and implications for low intensity breeding programs
Chapter 19
Questions, perspectives and final considerations under the global climate change conditioning.

Summary: This book demonstrates the significance of minimally invasive extracorporeal circulation and reduced time as two of the most important factors for pediatric cardiac surgery and early postoperative recovery. The content is divided into three major thematic sections: low invasiveness; pitfalls and countermeasures before, during and after operations; and suggestions on time saving and team building. Abundant figures aid in comprehension, while videos of the surgery offer practical insights for readers at all levels. Advances in extracorporeal circulation devices and management have led to new clinical problems such as decreased perfusion pressure, high pressures in oxygenators, and changes in acid-base equilibrium. The book explains these problems both clinically and experimentally, and describes countermeasures. Low Invasive Pediatric Cardiac Surgery provides valuable evidence and practical suggestions for all surgeons, perfusionists, scrub-nurses, and anesthesiologists who are engaged in pediatric cardiac surgery. It will also appeal to pediatric cardiologists and medical device manufacturers. The book is intended to share the authors experience and actual data with readers who have clinical experience, and to help prepare beginners. .

Contents:
Intro
Preface
Contents
About the Author
Part I: Extracorporeal Circulation and Low Invasiveness
1: Experience of Minimally Invasive Extracorporeal Circulation
1.1 Introduction
1.2 Implications of Invasion and Minimally Invasiveness in Cardiac Surgery
1.3 Extracorporeal Circulation Method for Minimally Invasive
1.4 History of Minimally Invasive Measures at Sakakibara Heart Institute
1.4.1 Establishment and Clinical Effect of Ultrafiltration Method
1.4.1.1 ECUM Effect in Infant VSD (1990) 1.4.1.2 ECUM Effect in Complete Atrioventricular Septal Defect (AVSD) (1992-1993)
1.4.2 Problems with Ultrafiltration
1.4.2.1 Protein Leakage (1991-1992)
1.4.2.2 Arrhythmia (1991-1993)
1.4.3 Advances in Ultrafiltration Methods
1.4.3.1 Measurement of Inflammatory Reactive Substances (1991-1993)
ECUM Only After the Start of Rewarming
Ultrafiltration During Aortic Cross-Clamp + During Rewarming
1.4.3.2 Measurement of Inflammatory Reactive Substances (1994-1995)
1.4.3.3 New Heart-Lung Machine and Inflammatory Reactive Substances (1997-1998) 1.5 Summary of Minimally Invasive
References
2: Development of Cardiopulmonary Bypass System and Devices Aiming for Minimally Invasive
2.1 Introduction
2.2 Development History
2.2.1 Low-Volume Oxygenator 1
2.2.2 Component Type Heart-Lung Machine
2.2.3 Low-Volume Oxygenator 2
2.2.4 Low-Volume Oxygenator 3
2.2.5 Isolated Pump-Controller Heart-Lung Machine 1
2.2.6 Low-Volume Oxygenator 4
2.2.7 Isolated Pump-Controller Heart-Lung Machine 2
2.2.8 Isolated Pump-Controller Heart-Lung Machine 3
2.2.9 The New Sakakibara Heart Institute 2.2.10 Transition of Priming Volume Reduction, Vacuum-Assisted Venous Drainage (VAVD)
2.2.11 Isolated Pump-Controller Heart-Lung Machine 4
2.2.12 Change in Priming Volume New Device
2.2.13 Current Priming Volume
2.3 Summary of Extracorporeal Circulation Devices
References
3: Advances in Bloodless Open-Heart Surgery
3.1 Introduction
3.2 Bloodless Open-Heart Surgery and Homologous Blood Transfusion
3.3 Bloodless Open-Heart Surgery for Acyanotic Congenital Heart Disease with Pulmonary Hypertension
3.3.1 1983-1992
3.3.2 1993
3.3.3 1994 3.3.4 Possibility of Bloodless Open-Heart Surgery for VSD Infant Weighing 4 kg (1995)
3.3.5 Bloodless Open-Heart Surgery in VSD Infants Weighing 3-4 kg (1997)
3.3.6 Bloodless Open-Heart Surgery for Complete AVSD: Comparison with VSD
3.3.7 Number of Blood Transfusions Used in Blood Priming Cases
3.4 Management and Measures for Bloodless Open-Heart Surgery in Low-Weight Infant
3.4.1 Determination of Indication for Bloodless Open-Heart Surgery
3.4.1.1 Indication Decision by Clinical Evaluation
3.4.1.2 Indication Decision by Hemodilution
3.4.2 Surgery
3.4.3 Anesthesia Management

Summary: Written by internationally acclaimed specialists, "Lower Abdominal and Perineal Surgery" provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Lower Abdominal and Perineal Surgery provides a valuable resource for all general surgeons and residents in training.

Contents:
Colorectal Surgery
Anal Surgery
Pilonidal Sinus Surgery
Penile, Scrotal, Testicular Surgery.

Summary: This book describes and discusses the available joint preservation techniques for maintaining the stability homeostasis of the lower extremity joints - specifically the hip, knee, and ankle - following injury. Readers will find detailed coverage of anatomy, pathology, techniques for repair, restoration, and regeneration, and rehabilitation strategies. Joint preservation is an emerging field in Orthopaedics that represents a response to the limitations of joint replacement technology. Using the techniques now available, surgeons can try to prevent or delay the onset of osteoarthritis or other degenerative conditions affecting the joints, particularly in young patients. Furthermore, modern tissue engineering offers the potential for whole-joint resurfacing, thereby achieving complete restoration. Optimal implementation of these techniques depends upon further refinement of methods and continuing improvements in knowledge of biomechanics, biology, and anatomy. Against this background, the present book is an ideal guide to the latest treatment modalities that will appeal to all who wish to learn more about indications, goals, procedures, and expected outcomes.

Contents:
Intro
Foreword
Preface
Contents
Part I: Hip
1: Comprehensive Hip Preservation: Correction of Adult Hip Dysplasia and Repair of High-Grade Cartilage Injury
1.1 Introduction
1.2 Diagnostic Imaging in Adult Hip Dysplasia
1.3 Correction of Hip Dysplasia and Open Treatment of High-Grade Cartilage Injury
1.3.1 Periacetabular Osteotomy: Surgical Technique
1.3.2 Surgical Dislocation of the Hip: Surgical Technique
1.4 Cartilage Repair in the Setting of Alignment Correction
1.4.1 Marrow Stimulation in the Hip 1.4.2 Autologous Chondrocyte Implantation in the Hip
1.4.3 Mesenchymal Stem Cell/Signaling Cell Treatment of Hip Chondral Defects
1.4.4 Osteochondral Transfer and Transplantation in the Hip
1.5 Summary
References
2: Anatomy of the Hip Joint Preservation Point of View
2.1 Introduction
2.2 Blood Supply
2.3 Nerves
2.4 Hip Muscles
2.5 Hip Flexors
2.6 Hip Extensors
2.7 Hip Abductors
2.8 Hip Adductors
2.9 External Rotators
2.10 Internal Rotators
2.11 Remarks
References 3: Anatomy, Surgical Management, and Postoperative Outcomes of Acetabular Labral Tears
3.1 Introduction
3.2 The Anatomy of the Labrum
3.2.1 Innervation
3.2.2 The Vascular Supply
3.3 The Aetiology of Hip Labrum Disorders
3.3.1 Types of Labral Lesions
3.4 The Role of the Acetabular Labrum in Hip Disorders
3.4.1 The Function of the Labrum
3.4.2 Changes in Load Distribution
3.4.3 The Radiographic Characteristics of Labral Tears
3.4.4 Labral Tears and OA
3.4.5 Labral Tears and Hip Dysplasia
3.5 Patient Evaluation
3.5.1 Clinical Examination 3.5.2 Diagnostic Imaging
3.6 Surgical Treatment
3.6.1 Indications for Surgery
3.6.2 Surgical Technique for Labral Reconstruction
3.6.3 Postoperative Management (Debridement, Repair, Reconstruction)
3.6.3.1 Outcomes and Prognosis
3.6.3.2 Return to Sports
References
Part II: Knee
4: Bone Marrow Stimulation Techniques for Cartilage Repair
4.1 Introduction
4.2 The Different Basic Techniques for Bone Marrow Stimulation
4.2.1 Subchondral Drilling
4.2.2 Abrasion Arthroplasty
4.2.3 Microfracture
4.2.4 Mobilization (According to Steadman [3]) 4.2.4.1 Femoral Condyle and Tibia Plateau
4.2.4.2 Patella
4.3 Matrix-Associated Bone Marrow Stimulation Techniques (MA-BMS)
4.3.1 Carbon Rods and Pads
4.3.2 Trans Arthroscopic Implant
4.3.3 Implant of Carbon Fiber Plate
4.4 AMIC (Autologous Matrix-Induced Chondrogenesis)
4.4.1 Osteochondral Matrix Plugs
4.4.2 Coral Exoskeleton
4.4.3 Blood Clot Augmentation
4.4.4 UV Light Stabilized Gel for Cartilage Repair
4.4.5 Large Cartilage Bone Damage Treated with Bone Marrow Stimulation
4.5 Conclusion
References

Summary: "Adequate evaluation of lower limb wounds for salvage requires an itemized assessment of vascular, osseous, soft tissue, and functional deficits. Lower Extremity Reconstruction: A Practical Guide by renowned reconstructive surgeons and perforator flap masters J.P. Hong and Geoffrey G. Hallock presents an orthoplastic approach to this growing and challenging area of microsurgery. Throughout the well-illustrated text and videos, an impressive cadre of international surgeons share pearls and insights, including esoteric knowledge and step-by-step demonstration of techniques with pertinent case examples. This unique guide presents a practical, visual, and stepwise approach to learning and mastering a full array of flap and microsurgery approaches for traumatic, dysvascular, metabolic, and oncologic lower limb defects. Organized into 26 topic-specific chapters, the book covers a full spectrum of lower extremity topics-from wound prep, timing, closure alternatives, and therapy-to soft-tissue tumors and a new concept in drop foot treatment. Numerous videos demonstrate how surgeons can leverage workhorse options to prevent chronic non-healing wounds or amputations and achieve the goal of limb salvage"-- Provided by publisher.

Contents:
Our Introduction to Lower Extremity Reconstruction / Joon Pio Hong and Geoffrey G. Hallock
Assessment of the Normal and Impaired Lower Extremity / Rachel M. Clancy and Ronald M. Zuker
Indications for Vascular Intervention in Lower Extremity Reconstruction / David L. Colen and Lawrence B. Colen
Orthopaedic Evaluation of the Lower Extremity and the Concept of the Orthoplastic Approach / Shaun D. Mendenhall, Nicole A. Zelenski, Oded Ben-Amotz, Stephen J. Kovach, and L. Scott Levin
Surgical Approach to Pediatric Bone and Soft-Tissue Tumors of the Lower Extremity / Rachel M. Clancy, Karen W. Wong, and Ronald M. Zuker
Spare-Part Surgery / Marco Innocenti, Eric Santamaria, and Young Chul Suh
Using the Flap and Angiosome Concepts to Optimize Functional Lower Leg and Foot Amputations / Christopher Attinger
Vascular Anatomy of the Lower Extremity : A Practical Guide to Vascular Territories, Perforators, and Selection of Recipient Vessels / Alison Wong and Steven F. Morris
Importance of Vascularity and Selecting the Recipient Vessels in Lower Extremity Reconstruction / Joon Pio Hong, Changsik John Park, and Hyunsuk Peter Suh
General Wound Preparation and Timing / Casey T. Kraft, Ibrahim Khansa, and Jeffrey E. Janis
The Pertinence of the Reconstructive Ladder and the Reconstructive Elevator / Patrick L. Reavey and Lawrence J. Gottlieb
Nonflap Wound Closure Alternatives : Skin Graft, Skin Substitute, Skin Stretch, and Negative-Pressure Wound Therapy / Hyunsuk Peter Suh
The Process for Flap Selection by Region of the Lower Extremity / Geoffrey G. Hallock
The Basic Practical Lower Limb Muscle Local Flaps / Geoffrey G. Hallock
Basic Local Perforator Flaps of the Lower Extremity / Geoffrey G. Hallock, Mouchammed Agko, Hung-Chi Chen, S. Raja Sabapathy, Hari Venkatramani, and Madhu Periasamy
Common Versatile Free Flaps for the Lower Extremity / Geoffrey G. Hallock, Waleed Gibreel, Karim Bakri, and Samir Mardini
Supermicrosurgery Approach to the Lower Limb / Joon Pio Hong
Diabetic Foot Reconstruction / Joon Pio Hong
Rationale for Lower Limb Sensate Flaps / Joon Pio Hong
A New Concept in Drop Foot Treatment: Ninković's Technique-the Neuromusculotendinous Gastrocnemius Transfer / Milomir Ninković, Marina Ninković, and Alexander de Heinrich
Modern Concepts of Prosthetic Rehabilitation in Amputation of the Lower Extremity / Stefan Salminger, Clemens Gstoettner, Agnes Sturma, and Oskar C. Aszmann
Procurement of Thin Flaps as Indicated in the Lower Extremity / Joon Pio Hong
Bone Flaps and Bone Transport for Lower Limb Reconstruction / Matthew Iorio, Stephen Andrew Sems, and Steven L. Moran
Surgical Treatment for Lower Extremity Lymphedema / Isao Koshima, Hirofumi Imai, Shuhei Yoshida, Shogo Nagamatsu, Kazunori Yokota, Mitsunobu Harima, Shuji Yamashita, and Haruki Mizuta
Lower Limb Vascularized Composite Allotransplantation / Pedro C. Cavadas
Perioperative Care and Rehabilitation Specific to the Lower Limb / Manas Nigam, Michael V. Defazio, and Karen K. Evans.

Summary: This atlas, containing a wealth of clear operative images, is designed to enable trainee surgeons to visualise the surgical field for procedures specific to laparoscopic colorectal surgery, thereby facilitating understanding and learning of surgical techniques and avoidance of intra- and postoperative complications. Step-by-step guidance is provided for a wide range of procedures employed in patients with benign and malignant tumours, inflammatory bowel disease, diverticular disease, rectal prolapse and other conditions. Examples include right colectomy techniques, sigmoid colectomy, left hemicolectomy, total colectomy, panproctocolectomy, total mesorectal excision, Hartmann's procedure and its reversal and rectopexy. Throughout, meticulous attention is paid to surgical anatomy. Whenever considered necessary, additional line drawings are included to aid comprehension of particular steps in the surgery. Readers seeking to improve their comprehension of surgical anatomy and how to perform these operative procedures will find the atlas to be an unparalleled source of information and assistance. A complementary book from the same authors focuses on open colorectal surgery.

Contents:
1 Anatomy of the Small Intestine
2 Anatomy of the Large Intestine
3 Lap appendectomy
4 Lap formation of ileostomy and colostomy
5 Oncological Right Colectomy by Laparoscopic Medial-To-Lateral Approach With Total Mesocolic Excision
6 Laparoscopic Extended Right Colectomy
7 The Initial Retrocolic Endoscopic Tunnel Approach to a Laparoscopic-Assisted Radical Right Colectomy: A (Modified) Lateral-Medial Technique for the Complete Mesocolic Excision of the Right Colon
8 Lap right hemicolectomy for Crohn's Disease
9 Lap Sigmoid Colectomy for Diverticular Disease
10 Lap left hemicolectomy for cancer
11 Lap total colectomy for IBD (New technique
12 Lap panproctocolectomy + ileoanal pouch for UC
13 Robotic Total Mesorectal Excision
14 Laparoscopic low anterior resection and TME
15 Trans-anal Total Meso-rectal Excision
16 Lap Hartmann's
17 Lap reversal of Hartmann's
18 Laparoscopic Ventral Rectopexy for Rectal Prolapse
19 Laparoscopic Posterior Rectopexy for Rectal Prolapse
20 Laparoscopic surgery for endometriosis.

Summary: This atlas, containing a wealth of clear operative images, is designed to enable trainee surgeons to visualize the surgical field for procedures specific to open colorectal surgery, thereby facilitating understanding and learning of surgical techniques and avoidance of intra- and postoperative complications. Step-by-step guidance is provided for a wide range of procedures to the colon, rectum, pelvic floor, anus, and anal canal, in each case paying meticulous attention to surgical anatomy. The full range of potential indications for open surgery is considered, including benign and malignant tumors, inflammatory bowel disease, appendicitis, diverticulitis, hemorrhoids, anal fistulas, and rectal prolapse, among others. Whenever considered necessary, additional line drawings are included to aid comprehension of particular steps in the surgery. Readers seeking to improve their comprehension of surgical anatomy and how to perform these operative procedures will find the atlas to be an unparalleled source of information and assistance. A complementary book from the same authors focuses on laparoscopic colorectal surgery.

Contents:
I COLON 1 Surgical anatomy and embryology
2 Appendectomy
3 Diverticulitis
4 Crohn's Disease
5. Ulcerative Colitis
6 Benign Tumor
7 Ileocecal, sigmoid volvulus
8 Surgery for cancer of the right colon
9 Surgery for cancer of the transverse colon and flectures
10 Surgery for cancer of the left colon
11 Multivisceral resections
II RECTUM 12 Surgical anatomy and embryology
13 Benign tumors perianal excision including TEM
14 Rectal cancer, anterior/low, anterior resection with TME/PME
15 Lateral lymph node dissection
16 Abdominoperanal intersphincteric resection
17 Multivisceral resection
18 Intersphincteric, conventional and extralevator rectal excision
Gluteal muscle flap
19 Resection of pelvic bones
20 Flaps for reconstruction, VRAM flap
III. PELVIC FLOOR, ANUS, AND ANAL CANAL 21 Anatomy and embryology
22 Haemorrhoids
23 Anal fistulas
24 Entero- and rectocele, rectal prolapse
25 Sphincter substitute
26 Sacral nerve stimulation
27 Incontinence, sphincter repair
28 Perianal procedures (TEM, TAMIS).

Summary: The diagnosis and treatment described in this book is based on the combination of Ilizarov technique, Paleys principle and Qinsihe Natural Reconstruction theory. It covers all kinds of lower limb deformities, ranging from congenital deformities to acquired deformities, the sequelae of Poliomyelitis, Cerebral Palsy, Spina Bifida Sequelae, Traumatic Sequelae, Charcot-Marie-Tooth disease, Osteogenesis Imperfecta and Congenital Pseudarthrosis Tibia, etc. There are also lots of clinical tips and tricks such as how to reduce radiation exposure during orthopaedic surgeries, how to correct multiple limb deformities in one stage, how to balance the dynamic muscle in complex foot and ankle deformities, and how to successfully accomplish the surgery of difficult lower limb reconstruction without allogeneic blood transfusion, etc. It is a valuable reference for orthopaedic surgeons and advanced trainees worldwide who interested in deformity correction and limb reconstruction.

Contents:
Intro
Preface
First, the Origin of the Qin Sihe Orthopedic Surgery
Second, Dr. Qin Carried Out Excessive Surgery in the Cold Hei Long Jiang Province
Third, Qin Sihe Entered Beijing to Set Up a Physical Disability Correction Center
Fourth, Qin Sihe Took the Lead in Studying and Introduced the Ilizarov Method from Russia to China
Fifth, Qin Sihe Has Created a Convenient and Efficient "Individualized Diagnosis and Technical Route"
Sixth, the Establishment of Case Database for Orthopedic Surgery
Seventh, Qin Sihe Became Acquainted with Western Orthopedics Circles Eighth, the Important Time Nodes
Ninth, Dr. Qin Sihe's Gift to the World Orthopedics Academia
Informative Abstract
Disclosure
Acknowledgment
Contents
1: Introduction
1.1 Limb Deformity and Dysfunction
1.1.1 General Situation of People with Limb Dysfunction in China
1.1.2 Current Situation of Orthopedic Surgery in China
1.1.3 The Origin, Formation, and Development of Qinsihe Orthopedic
1.2 Basic Surgical Technique
1.2.1 Soft Tissue Release
1.2.2 Bony Osteotomy
1.2.3 Tendon Transfer 1.2.3.1 Relationship Between Immobilization and Exercise After Tendon Transposition
1.2.3.2 The Following Factors Must Be Considered in Tendon Transfer
1.2.4 Arthrodesis
1.2.5 Lengthening and Equalization for Lower Limb
1.2.6 Qinsihe Plaster Method for Lower Limb Deformity
1.3 The Art of Minimally Invasive Surgery
1.3.1 Surgical Skill
1.3.2 Art of Surgery
1.3.3 Relation of Surgical Speed and Quality
1.3.4 Which Factors Make the Surgery Faster and Better?
1.3.4.1 Strategic Element: Master the Wisdom of Winning 1.3.4.2 Tactical Elements: Surgeon's Martial Arts
1.3.4.3 The Magical Use of Conventional Orthopedic Instruments, Rarely Use X-Ray Examination During Surgery
1.3.5 Clinical Application of Qinsihe Mini-invasive Surgery
1.3.5.1 Main Application
1.3.5.2 Special Surgical Instruments
1.3.5.3 Suggestions for Subcuticular Releasing of Tendon and Membrane
1.3.5.4 Indications and Clinical Application of Mini-invasive Technique
1.3.6 Rational Application of Tourniquet
1.4 Preoperative Examination
1.4.1 Lower Extremity Deformity Checklists and Records 1.4.2 Preoperative Examination
1.4.3 Physical Examination
1.4.4 Lower Limb Deformity Surgical Treatment Evaluation Procedure
1.5 Surgical Indications and Expected Outcomes
1.5.1 Surgical Indications
1.5.2 Purpose and Outcome of Lower Limb Orthopedic Surgery
1.5.3 The Patients Should Undergo Surgery as Soon as Possible
1.5.4 Surgical Goal Designing
1.6 Advantages of Surgical Treatment of Lower Extremity Deformity
1.7 Surgical Decision Making
1.7.1 Principle of Lower Limb Surgery
1.7.2 How to Make a Correct Surgical Plan

Contents:
1. Tendonitis, tendinosis, or tendinopathy?
2. Healing processes of the tendon
3. Adductor tendinopathy
4. Rectus femoris tendinopathy
5. Iliopsoas tendinopathy
6. Quadriceps tendinopathy
7. Iliotibial band syndrome (ITBS)
8. Hamstring syndrome
9. Pes anserine tendinopathy
10. Achilles tendinopathy
11. Patellar tendinopathy
12. Hindfoot tendinopathies
Index.

Summary: "Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia: From Research to Bedside offers full acknowledgment of the basic research of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), also connecting the clinical and practice management of the disease. It provides a full comprehension of LUTS and BPH from several aspects, allowing for a schematic interpretation of the disease and subsequent medical management. Going beyond the guidelines in the field, this title enhances the knowledge of BPH onset, allowing for the advancement of research, beneficial clinical implication and treatment. Perfect for researchers, urologists, pathologists and endocrinologists, this must-have reference provides what is needed to understand LUTS and BPH in one easy to reference place.Provides a clear understanding of the pathological mechanisms that are present in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH)Incorporates research with the clinical aspects of LUTS and BPH, including surgical techniquesPresents an overview of LUTS and BPH in one easy to reference place."-- Provided by publisher.

Summary: This book provides an in-depth insight into the symptoms and symptom complexes affecting the lower urinary tract and the underlying causative conditions. The emphasis throughout is practical and clinical, with coverage of all levels of the patient pathway. In addition to the extensive guidance on diagnostic assessment and interpretation, the management of voiding and storage lower urinary tract symptoms, including incontinence, is fully described and potential complications and neurological conditions are discussed. Information is also included on relevant basic science and epidemiology. Lower Urinary Tract Symptoms in Adults: A Clinical Approach will be an ideal source of expert knowledge for practitioners in functional urology, urogynecology, and neuro-urology gerontology. .

Contents:
The Urinary Tract: Form and Function
The Lower Urinary Tract Symptoms
Conditions and Syndromes
LUTS assessment
Treatment of Voiding LUTS
Treatment of Storage LUTS
Influences and Complications
Neurological Diseases and LUTS.

Contents:
Destiny of the species : welcome to the lucky years
The century of biology : the cure is already inside you
This isn't science fiction : the power of technology to extend your life
The future you : how your small data in the context of big data will save you
The dawn of precision medicine : how to manage its power and perils
Take the two-week challenge : how to measure and interpret your own data
The danger of misinformation : how to know whom and what to trust
A body in motion tends to stay lucky : the one supplement you're not getting enough of
Wonder drugs that work : sleep, sex, touching, and tools to tame inflammation
The butterfly effect : get ready to flap your wings.

Summary: "Authored by experienced surgeons and key innovators in the fast-moving field of LIF surgery, Lumbar Interbody Fusions provides an in-depth, focused approach to recent advances in surgical techniques and technology. Covering both minimally invasive and open procedures, this comprehensive reference provides step-by-step details for proven techniques, including extreme lateral, oblique lateral, and direct lateral approaches; intertransverse approaches; axial approaches; and endoscopic approaches"--Publisher's description.

Contents:
Section 1: Lumbar interbody fusions: a primer. General indications and contraindications
Complications and avoidance in lumbar interbody fusions
Section 2: Anatomy and intraoperative imaging for lumbar interbody fusion. Relevant surgical anatomy of the dorsal lumbar spine
Relevant surgical anatomy of the lateral and anterior lumbar spine
Intraoperative image-guided navigation for lumbar interbody fusion
Section 3: Techniques, pearls, and complication avoidance in lumbar interbody fusions. Mini-open anterior lumbar interbody fusion (ALIF)
Posterior lumbar interbody fusion (PLIF)
Transforaminal lumbar interbody fusion (TLIF)
Minimally invasive transforaminal lumbar interbody fusion (MITLIF)
Minimally invasive midline lumbar fusion (MIDLIF)
Lateral transpsoas approach to interbody fusion
Pre-psoas (oblique) lateral interbody fusion
Pre-psoas (oblique) lateral interbody fusion at L5-S1
Interlaminar lumbar instrumented fusions (ILIF)
Endoscopic lumbar interbody fusion
Section 4: Adjunct instrumentation in lumbar interbody fusion. Interbody implant options in interbody fusion
Biologic options in interbody fusion
Integrated screw/plate interbody fusion devices
Spinous process plates for lumbar fixation
Instrumentation for stability after lumbar interbody fusion
Section 5: Special considerations. Revision interbody fusion
Interbody fusion strategies in thoracic and sacral overlap diseases
Evidence-based report on interbody fusions of the lumbar spine

Summary: This book provides a comprehensive but concise overview on the economically important emerging cattle pox virus derived Lumpy Skin Disease, including the characteristics of causative agent, description of clinical signs in cattle, pathology and histopathology, immunity, geographical distribution, epidemiology and transmission pathways, control and eradication of the disease. In addition the recent developments in vaccination, mathematical modeling and risk assessment are discussed. Lumpy Skin Disease currently spreads aggressively across the Middle and Near East. The first incursion to the European Union territory occurred in Greece in autumn 2015. The book targets clinicians and field veterinarians in Lumpy Skin Disease affected regions, veterinary authorities as well as advanced students in veterinary medicine and virology.

Contents:
Intro; Contents;
1: Introduction to Lumpy Skin Disease;
2: General Description of Lumpy Skin Disease; References;
3: Economic Impact of Lumpy Skin Disease; 3.1 Direct Impact of Clinical Disease; 3.2 Indirect Economic Impact of LSD; References;
4: Geographic Distribution of Lumpy Skin Disease; References;
5: Current Legislation and Trade Recommendations; References; Part I: Lumpy Skin Disease Virus;
6: Taxonomy; References;
7: Morphology; References;
8: Genome; References;
9: Replication in a Host; References;
10: Propagation of the Virus In Vitro; References.
11: Persistence and Stability of the VirusReferences;
12: Immunity; References;
13: Epidemiology and Transmission; 13.1 Transmission Modes of LSDV; 13.2 Potential Vectors of Lumpy Skin Disease Virus; 13.3 Direct Transmission of Lumpy Skin Disease; 13.4 Transmission Via Subclinically Infected Cattle; 13.5 Spread of Lumpy Skin Disease; 13.6 Seasonality; 13.7 Geographical Risk Factors; 13.8 Risk Factors in the Herd Level; 13.9 Risk Factors in the Animal Level; 13.10 Further Suggested Studies; References; Part II: Early Detection of Lumpy Skin Disease, Diagnostic Tools and Treatment.
14: Clinical SignsReferences;
15: Sample Collection and Transport; References;
16: Diagnostic Tools; References;
17: Treatment of Lumpy Skin Disease; Part III: Control and Eradication;
18: Vaccines Against LSD and Vaccination Strategies; 18.1 Vaccination Strategies; References;
19: Slaughter of Infected and In-Contact Animals; References;
20: Animal Movement Control and Quarantine; References;
21: Vector Surveillance and Control; 21.1 Vector Surveillance; 21.2 Vector Control; References;
22: Decontamination and Disinfection; References;
23: Active and Passive Surveillance; References.

Summary: Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area.

Summary: "Care of the lung cancer patient--screening, diagnosis, and treatment--has undergone recent dramatic changes due to technologic and research-driven advances. Lung Cancer: An Evidence-Based Approach to Multidisciplinary Management covers every aspect of this fast-changing field, including new screening guidelines, new practice standards, and new treatment advances that have led to higher survival rates. This practical, clinically oriented resource provides thorough, evidence-based coverage from experts in the field, including the increasingly important precision medicine approach in lung cancer planning and management"-- publisher's description.

Contents:
Lung cancer screening and prevention
Lung cancer: Diagnostic techniques
Histology and molecular testing
Surgical considerations in lung cancer treatment
Surgically resectable disease
Oligometastatic disease
Locally advanced non-small cell lung cancer
First-line therapy
Second-line therapy in advanced non-small cell lung cancer
Epidermal growth factor receptor-mutated non-small cell lung cancer: a clinical approach
Diagnosis a nd treatment of anaplastic lymphoma kinase (ALK) rearranged non−small cell lung cancer
Other molecular cohorts including ROS1, BRAF, HER2, MET, NT RK, RET, KRAS
Immunotherapy
Small cell lung cancer.

Summary: Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach. For targeted and immunotherapeutic approaches, understanding the biology of acquired resistance is a key strategy that has yielded productive advances in the subsequent treatment. Future advances also include incorporating biomarker data obtained from solid and liquid biopsies, as well as combination of immunotherapy with radiotherapy and in special populations such patients with CNS involvement.

Contents:
Tumor Microenvironment: Immune Effector and Suppressor Imbalance
Biomarkers: is tumor mutational burden the new prognostic grail?
Liquid biopsies: new technology and evidence
Osimertinib in EGFR-Mutant Non-Small Cell Lung Carcinoma: Clinical Activity and Mechanisms of Resistance
What can we learn from acquired resistance?
Management of Brain Metastases
Spectrum and Management of Immune Related Adverse Events Due to Immune Checkpoint Inhibitors
Therapeutic Advances in Small Cell Lung Cancer Management
Small Cell Lung Cancer: Biology Advances
Immunotherapy and Radiotherapy: New Strategies
Ultimate Precision: Targeting Cancer but not Normal Self-Replication
Index.

Summary: "Covers the new standards of care and helps you to remain current on lung cancer for practice, board review, and re-certification in a very easy-to-read, concise and quick to digest format. The fast-changing paradigms of care are presented in print, e-book and the on line access will be updated annually"-- Provided by publisher.

Contents:
History of Lung Cancer / Goetz Kloecker
Epidemiology of Lung Cancer / Goetz Kloecker
Etiology of Lung Cancer / Goetz Kloecker
Tobacco and Lung Cancer / Goetz Kloecker, Brian Dong, Rohit Kumar
Economics of Lung Cancer / Jorge Rios, Shruti Bhandari
Pathobiology of Non-Small Cell Lung Carcinoma / Mostafa Fraig
Pathobiology of Small Cell Carcinoma and Other Neuroendocrine Tumors of the Lung / Mostafa Fraig
The Stem Cell Hypothesis of Lung Cancer / Christine Fillmore Brainson
Prevention of Lung Cancer / Susanne Arnold
Early Detection of Lung Cancer / Shruti Bhandari, Dhan Pham
Diagnostics of Lung Cancer / Shruti Bhandari, Dhan Pham, Chandler Park, Samuel Reynolds, Bilal Athar Jalil, Umair Gauhar, Emily Jonczak, Raja Mudad
Staging of Lung Cancer / Susanne Arnold
Non-Small Cell Lung Cancer Treatment : Early Stage / Matthew Fox, Victor van Berkel, Neil Dunlap, Phuong Ngo, Luis E. Raez, Rohit Kumar, Jose Pinto-Llerena, Ignacio Gil-Bazo, Jonathan Rice, Katy Alyse Marino, Mike May
Non-Small Cell Lung Cancer Treatment : Locally Advanced / Matthew Fox, Neal Dunlap, Michael May, Rohit Kumar, Luis Raez, Andrea Anampa-Guzmán, Ignacio Gil-Bazo, Cesar A. Perez
Non-Small Cell Lung Cancer Treatment : Metastatic / Andrew Tumen, Katy Alyse Marino, Victor van Berkel, Neal Dunlap, Steven Mandish, Phuong Ngo, Moises Harari Turquie, Jose Pinto Llerena, Gil Bazo, Edgardo S. Santos, Cesar Perez, Jennifer Cudris
Small Cell Lung Cancer Treatment : Early Stage / William. M Whited, Kate Alyse Marino, Matthew Fox, Victor van Berkel, Phuong Ngo, Neal Dunlap, Mehran Yusuf, Alden Klarer
Small Cell Lung Cancer Treatment : Locally Advanced / Phuong Ngo, Neal Dunlap, Mehran Yusuf, Diana Saravia, Cesar Perez
Small Cell Lung Cancer Treatment : Metastatic / Phuong Ngo, Neal Dunlap, Mehran Yusuf, Muhammad Husnain, Cesar Perez
Supportive and Palliative Care in Lung Cancer / Shruti Bhandari, Jonathan S. Alexander
Interventional Radiology in the Diagnosis and Treatment of Lung Cancer / Douglas M. Coldwell, Omar Zuberi
Immunotoxicity / Amitoj Gill, Rahul Gosain
Pulmonary Carcinoid / Hamza Hashmi
Malignant Pleural Mesothelioma / Hamza Hashmi
Thymoma / Hamza Hashmi.

Contents:
Lung cancer screening
Diagnosis and molecular classification of lung cancer
Lung cancer staging and prognosis
Surgical treatment of lung cancer
Treatment: radiation therapy
Chemotherapy for advanced non-small cell lung cancer
Multimodality therapy for NSCLC
Targeted therapies for lung cancer
Resistance to therapy
Immunotherapy in lung cancer
Palliative care in lung cancer
Management of lung cancer in the elderly
Multidisciplinary care
Small cell lung cancer.

Summary: Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.

Contents:
1. Lung Cancer Statistics
2. Epidemiology of Lung Cancer
3. Lung Cancer In Never Smokers
4. Immune Therapy
5. Anti-angiogenesis in personalized therapy of lung cancer
6. Target therapy in Lung Cancer
7. Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: an update
8. KRAS-Mutant Lung Cancers in the Era of Targeted Therapy
9. Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer
10. Chemotherapy Resistance in Lung Cancer
11. Current state of metal-based drugs for the efficient therapy of lung cancers and lung metastases.

Contents:
Lung cancer genomics in the era of accelerated targeted drug development / Priyanga Wijesinghe and Aliccia Bollig-Fischer
Emerging biomarkers in personalized therapy of lung cancer / Philip T. Cagle, Kirtee Raparia, and Bryce P. Portier
Epithelial mesenchymal transition in aggressive lung cancers / Vivek Mittal
The role of cancer stem cells in recurrent and drug-resistant lung cancer / Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip A. Philip
The microenvironment of lung cancer and therapeutic implications / Vivek Mittal, Tina El Rayes, Navneet Narula, Timothy E. McGraw, Nasser K. Altorki, and Mary Helen Barcellos-Hoff
Epigenetics in personalized management of lung cancer / Aamir Ahmad
Next-generation sequencing and applications to the diagnosis and treatment of lung cancer / Kristina M. Kruglyak, Erick Lin, and Frank S. Ong
Nanomedicine for treatment of lung cancer / Sajid Hussain
Personalized therapy of small cell lung cancer / Bryan J. Schneider and Gregory P. Kalemkerian
Personalized radiation therapy (PRT) for lung cancer / Jian-Yue Jin and Feng-Ming (Spring) Kong
Personalized therapy of non-small cell lung cancers (NSCLC) / Shirish M. Gadgeel.

Summary: "Edited by cancer rehabilitation specialist Dr. Adrian Cristian, Lung Cancer Rehabilitation provides clinicians with a concise and accessible resource covering the holistic rehabilitation of lung cancer patients. Beginning with the epidemiology, genetics, and pathophysiology of lung cancer, it then covers clinical assessment and treatment options before providing comprehensive coverage of rehabilitation. Offering practical information, best practices and the latest advances and research, this book is a valuable reference for physical medicine and rehabilitation physicians and residents, as well as occupational therapists and physical therapists"-- publisher's description.

Contents:
An Overview of the Epidemiology, Types of Lung Cancer, Staging, and Rehabilitation Continuum of Care
Systemic Therapy and Radiation Therapy in Lung Cancer
The Assessment of the Person With Lung Cancer and Implications for the Rehabilitation Clinician
Assessment, Treatment, and Rehabilitation of Bone and Spinal Metastasis in Lung Cancer
Lung Cancer in the Palliative Care Setting: Successes, Challenges, and Opportunities for Collaboration
Psychosocial Distress and Anxiety in Lung Cancer
Lung Cancer SurvivorshipExercise and Lung Cancer
Lung Cancer Book—Prehabilitation Chapter
Cancer-Related Fatigue in Lung Cancer
Sarcopenia and Frailty in Lung Cancer
Nutritional Considerations in Lung Cancer Rehabilitation
Pain Management in Lung Cancer Rehabilitation
Cognitive Impairment in Lung Cancer and Brain Metastases
Neuropathy in Lung Cancer
Complications and Rehabilitation Challenges of Lung Cancer Surgeries
Musculoskeletal and Neurological Complications of Check Point Inhibitors
Functional Outcomes in Lung Cancer Rehabilitation
Telemedicine in Lung Cancer Rehabilitation.

Contents:
1. Lung Cancer Epidemiology.
2. Risk Factors for Lung Cancer.
3. Evolution of Lung Cancer Screening.
4. Lung Cancer Screening Pros and Cons.
5. Variable Imaging Presentations of Lung Cancer.
6. Lung Cancer-Screening Results Reporting.
7. Detection and Management of Unexpected Incidental Pulmonary and Nonpulmonary Findings.
8. Elements of a Successful Lung Cancer-Screening Program.
9. Future of Lung Cancer Screening.
10. Test Cases: Applying Lung CT Screening Reporting and Data System (Lung-RADS).

Summary: Lung cancer is the second most diagnosed cancer and remains the leading cause of cancer-related deaths in the United States. The high mortality is largely the consequence of late diagnosis; lung cancer is typically asymptomatic in early stages when a surgical cure is most likely. As a result, there has been great interest in and research on early detection of lung cancer through screening. There is evidence for reduced disease-specific mortality through screening for lung cancer. However, creating an integrated, systematic approach to lung cancer screening remains a challenge for providers. A successful lung cancer screening program weighs the benefits and harms of screening, clearly defines the target population and the screening process, and does not exclude eligible patient populations based on race, ethnicity, or socioeconomic status, In addition it should promote shared decision-making and address risk reduction. Lung Cancer Screening: Practical Aspects for Primary Care provides a comprehensive and pragmatic guide to screening for lung cancer in real world clinical practice. The first two chapters summarize the epidemiology, risk factors and disparities in lung cancer, and provide the evidence base for screening for lung cancer. The disparities in lung cancer among different groups within the US population are well known. This text highlights how health disparities in lung cancer affect screening and have led to modification of lung cancer screening guidelines. Subsequent chapters provide a guide to implementing a successful lung cancer screening program and address the barriers that arise during implementation. The book concludes withreal-world solutions to overcoming barriers in lung cancer screening. This pocket guide is an essential read and bookshelf reference for providers who do not have the specialized knowledge of screening for lung cancer. It also appeals to pulmonologists, fellows in Pulmonary Medicine, chest radiologists, and advanced practice providers with an interest in setting up lung cancer screening in any clinical practice.

Contents:
Epidemiology of Lung Cancer and Risk Factors
Health Disparities in Lung Cancer Screening
Best Practices in Lung Cancer Screening
Implementing Lung Cancer Screening in Clinical Practice
Innovations in Integrating Smoking Cessation and the Shared Decision-Making Discussion into Lung Cancer Screening
Lung Cancer Screening Results and Tracking.

Summary: This comprehensive text expounds the pathophysiology, diagnosis, and treatment of lung disease associated with rheumatoid arthritis (RA), an autoimmune disease that primarily affects joints. Recent advances in therapy for RA provide the benefit of achieving a better outcome in patients with arthritis, and a large number of reports on RA are now available. Moreover, the American College of Rheumatology and the European League Against Rheumatism have proposed guidelines and recommendations for management of RA patients. Therefore, clinicians around the world can adequately understand how to manage patients who have joint symptoms in RA. At the same time, however, the management of RA patients who have lung problems has not been disseminated sufficiently, although lung disease is a common complication in approximately 30-40 % of patients with RA. Unfortunately, there has been a lack of tangible evidence regarding the pathophysiology, diagnosis, and management of lung disease associated with RA. Each expert author in this book elucidates the current status of knowledge about lung disease in RA and the management of RA patients with lung diseases. Thus this valuable collection benefits not only rheumatologists but also respirologists, radiologists, pathologists, general practitioners, and medical staff such as nurses who are involved in the management of RA.

Contents:
Part I. Introduction
1. Overview: Clinical significance of lung disease associated with Rheumatoid Arthritis
Part II. Airway disease in Rheumatoid Arthritis
2. Comprehensive understanding of airway disease in Rheumatoid Arthritis
3. Pathology of airway disease in rheumatoid arthritis
4. Imaging of Airway diseases of rheumatoid arthritis
5. Therapeutic strategy for airway disease in Rheumatoid Arthritis
Part III. Interstitial lung disease in Rheumatoid Arthritis
6. Comprehensive understanding of interstitial lung disease in rheumatoid arthritis
7. Pathology of interstitial lung disease in patients with rheumatoid arthritis
8. Radiological characteristics of interstitial lung diseases in patients with connective tissue disease: focus on rheumatoid arthritis
9. Therapeutic strategies for interstitial lung diseases in Rheumatoid Arthritis
Part IV. Diagnosis and treatment of acute lung disease in Rheumatoid Arthritis
10. Bacterial and Fungal Infections in Rheumatoid Arthritis
11. Mycobacterium infections in Rheumatoid Arthritis (tuberculosis and nontuberculous mycobacteriosis)
12. Organizing Pneumonia in Rheumatoid Arthritis
13. Acute pulmonary infiltrates in patients with rheumatoid arthritis: Differential diagnosis and management.

Contents:
Junctional interplay in lung epithelial barrier function / Michael Koval
Ion transport and lung fluid balance / Charles Downs
Glucose transport and homeostasis in lung epithelia / Deborah L. Baines and Emma H. Baker
Pulmonary surfacant trafficking and homeostasis / Joseph L. Alcorn
Integrin regulation of the lung epithelium / Erin Plosa and Roy Zent
Epithelial regeneration and lung stem cells / Shama Ahmad and Aftab Ahmad
The function of epithelial cells in pulmonary fibrosis / Shijing Jia and Kevin K. Kim
The role of epithelial cell quality control in health and disease of the distal lung / Michael F. Beers, Shin-ichi Nureki and Surafel Mulugeta
The respiratory epithelium in COPD / Chad H. Hochberg and Venkataramana Sidhaye
Acute respiratory distress syndrome / Rachel L. Zemans
Epithelial barrier dysfunction in asthma / Janelle Veazey, Tim Smyth and Steve N. Georas
Cystic fibrosis / Samuel A. Molina and William R. Hunt.

Summary: This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health.

Contents:
Air Matters: The Effect of Ozone and Traffic Related Air Pollution on the Airways
Environmental Factors on Lung Health in Cystic Fibrosis and non-Cystic Fibrosis Bronchiectasis
Molds and Respiratory Disease
Occupational Exposome and Lung Health
Environmental and Pollution Related Risks for Hypersensitivity Pneumonitis
Lung Cancer in Never Smokers
Acute and Chronic Lung Disease from Recreational Inhalants
Pulmonary Hypertension and Air Pollution
Climate Change and the Lung Exposome.

Summary: Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung diseases are neither always effective, nor often condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases are not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung diseases, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, fellows, and students with new perspectives and concepts. The editor hopes this book will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Contents:
1. Potential role of mast cells in regulating corticosteroid insensitivity in severe asthma
2. Galectin-3 Promotes ROS, Inflammation and Vascular Fibrosis in Pulmonary Arterial Hypertension
3. Anti-Inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials
4. Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension
5. Pulmonary Inflammation and KRAS Mutation in Lung Cancer
6. microRNA Targets for Asthma Therapy
7. Roles of genetic predisposition in the sex-bias of pulmonary pathophysiology, as a function of estrogens
8. Hypercapnic respiratory failure-driven skeletal muscle dysfunction: It is time for animal mod-els-based mechanistic research
9. Role of airway smooth muscle in inflammation related to asthma and COPD
10. Systemic Sclerosis and Pulmonary Disease
11. Innate Lymphoid Cells in airway inflammation
12. Sjogren's Syndrome and pulmonary disease
13. Redox Regulation, Oxidative Stress and Inflammation in Group 3 Pulmonary Hypertension
14. Sex-Steroid Signaling in Lung Diseases and Inflammation
15. Cytokines, Chemokines and Inflammation in Pulmonary Arterial Hypertension
16. Interactive roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases
17. Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis
18. Crosstalk between Lung and Extrapulmonary Organs in Infection and Inflammation
19. Inflammation in Pulmonary Arterial Hypertension
20. Lysophospholids in Lung Inflammatory Diseases.

Summary: This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.

Contents:
Intro; Dedication; Foreword; Foreword; Preface; Acknowledgments; Contents; About the Author; List of Figures; Introduction;
Chapter 1: Brief Overview of the Human Respiratory System Structure and Development; 1.1 Brief Overview of the Structure of Human Respiratory System; 1.2 Brief Overview of the Development of Human Respiratory System;
Chapter 2: Diversity of Lung Stem and Progenitor Cell Types; 2.1 Alveolar Epithelial Stem and Progenitor Cells; 2.1.1 Localization and Characterization; 2.1.2 The Repair and Regeneration Capacities and Mechanisms. 2.2 Tracheal and Bronchial Epithelial Stem and Progenitor Cells2.2.1 Localization and Characterization; 2.2.2 The Repair and Regeneration Capacities and Mechanisms; 2.3 Lung Mesenchymal Stem and Progenitor Cells; 2.3.1 Lung Vascular Endothelial Stem and Progenitor Cells; 2.3.2 Lung Smooth Muscle Stem and Progenitor Cells; 2.3.3 The Repair and Regeneration Capacities;
Chapter 3: Signals and Molecular Mechanisms Controlling Lung Stem/Progenitor Cell Development and Behavior; 3.1 Signals and Genes Regulating General Lung Cell Growth and Development. 3.2 Signals and Genes Regulating Lung Stem/Progenitor Cell Behavior: The Self-Renewing and Differentiation3.2.1 Role of Transcription Factors; 3.2.2 Role of Growth Factors; 3.2.3 Role of Micro-RNAs (miRNAs); 3.2.4 Role of Other Factors and Signal Molecules; 3.2.5 Role of the Epigenetic Factors; 3.3 Regulatory Signal Mechanisms of Stem and Progenitor Cells During Lung Repair and Regeneration;
Chapter 4: Signals and Molecular Mechanisms Regulating Stem Cell Behavior in Other Systems (e.g., Hematopoietic Stem Cells); 4.1 Hierarchy and Heterogeneity of Hematopoietic Stem and Progenitor Cells.
Chapter 5: Mode of Cell Division as a Regulatory Mechanism for Lung Stem Cell Behavior Compared to Other Systems5.1 Asymmetrical Divisions of Stem Cells in Different Systems; 5.1.1 Intestinal Stem and Progenitor Cells of Drosophila; 5.1.2 Hematopoietic Stem and Progenitor Cells; 5.1.3 Muscle Stem and Progenitor Cells; 5.1.4 Epidermal Stem and Progenitor Cells; 5.1.5 Neural Stem and Progenitor Cells; 5.2 Asymmetrical Divisions of the Lung Epithelial Stem and Progenitor Cells; 5.2.1 Numb as a Key Regulator of Asymmetric Cell Division and Cell Fate in the Lung.

Summary: This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Written by global experts, chapters present general principles and history; indications and eligibility for lung transplantation, including screening for COPD, cystic fibrosis, scleroderma, Idiopathic pulmonary fibrosis (IPF) and idiopathic pulmonary arterial hypertension; approach to and complications of lung transplantation, such as prognostic markers, radiological approach, and immunology and rejection; and medical and surgical guidelines for lung transplantation. The goal of lung transplantation is to increase survival and to provide a greater quality of life for patients with untreatable end-stage lung disease and this book serves to best prepare clinicians in achieving that goal. Lung Transplantation: Evolving knowledge and New horizons offers valuable insights into this modality and is an authoritative resource for multidisciplinary services that include experts in pulmonary diseases, critical care, cardiology, thoracic surgery, infection diseases, internal medicine, radiology, immunology, nephrology, rehabilitation, psychology /psychiatry, nurses, social workers and nutritionists.

Contents:
General principles and considerations for lung transplantation
The donor lung and the lung transplant recipient
The lung transplant recipient : medical management
Lung transplantation : future directions.

Contents:
The tools of the BLUE-protocol: Basic notions: the indispensable
Which unit
Which probe
Specific notions
The seven principles of L.U.C.I.
The BLUE-points
The 10 signatures at a glance
The pleural line
The A-profile and the A-line
The A-profile and lung sliding
The B-line
Interstitial syndrome and lung rockets
The B-profile, the B'-profile
The A'-profile and pneumothorax
PLAPS
PLAPS and pleural effusion
PLAPS and lung consolidation. The C-profile
BLUE-DVT. Deep venous thrombosis in the BLUE-protocol
Simple emergency cardiac sonography
The BLUE-protocol in clinical use: Basic principle of the BLUE-protocol. The 8 profiles. The data
Excluded patients of the BLUE-protocol
Frequently asked questions on the BLUE-protocol
The BLUE-protocol and pneumonia.- The BLUE-protocol and acute hemodynamic pulmonary edema
The BLUE-protocol, asthma and COPD
The BLUE-protocol and pulmonary embolism.- The BLUE-protocol and pneumothorax.- The main products derived from the BLUE-protocol: Pink-protocol (lung ultrasound in ARDS)
The LUCI-FLR project (decrease of medical irradiation)
FALLS-protocol (heart, lung, venous ultrasound in management of acute circulatory failure).- SESAME-protocol (ultrasound in cardiac arrest).- Extension of lung ultrasound to specific disciplines, wider settings, various considerations: Lung ultrasound in the neonate.- All specialties involved in lung ultrasound.- Critical ultrasound, lung, heart and DVT apart.- The Extended BLUE-protocol.- Non critical ultrasound.- Various considerations.- How to learn the BLUE-protocol.- Holistic ultrasound, a new definition
how it can impact critical medicine.- Lung artifacts from A to Z.

Summary: This book on lupin genomics primarily focuses on the narrow-leafed lupin (NLL), and details the genomic resources that have been developed and how they are currently being used to help advance both fundamental and applied research on NLL in areas ranging from its domestication to plant-microbe interactions and syntenic relationships between NLL and other legume crops. It also reports on genomic efforts being pursued with regard to other lupin crops. Lupins are important ecological 'engineers': they can colonise and thrive in low-nutrient soils due to their ability to fix atmospheric nitrogen in symbiosis with bacteria and efficiently take up phosphorous. Recently, lupins have attracted considerable interest, not only because of their value for sustainable farming as a break crop, but also as a potential 'super food' for fighting major health issues in connection with diabetes and obesity. Narrow-leafed lupin is the main grain legume crop, grown primarily in Australia, and was therefore selected for the development of a reference lupin genome and associated genomic resources. Its genome has recently been sequenced with a focus on the gene-rich space, which has advanced the development of new breeding tools for the improvement of NLL and related lupin crops.

Contents:
Introduction to lupins and their importance
Lupin breeding
lessons from the past and prospects for the future
Ecophysiology and genetic resources for genetic/genomic improvement of NLL
NLL reference genome
Cytomolecular insight into/Lupinus/ genomes
NLL transcriptomics
Molecular marker resources
Targeted towards Australian breeding program
Syntenic relationships between NLL and other legume crops
Exploiting NLL genomic resources to understand NLL domestication
Genomic applications to dissect plant-microbe interactions
Genomic applications to dissect flowering time control in NLL
GBS-based genomic selection in white lupin
Genomic efforts for L. luteus
L. mutabilis genome and associated evolutionary analyses
Genomic efforts to analyse repetitive elements in lupin species.

Summary: "In this new, completely updated edition of The Lupus Encyclopedia, Dr. Thomas along with leading experts from around the globe detail everything you need to know about what lupus is and how autoimmune disorders affect the body and mind, the symptoms associated with lupus, what tests are needed to make a lupus diagnosis, how to find a specialist who can provide you with the best care, advice on obtaining the best treatments for your specific symptoms, and lifestyle factors that can help you avoid flare-ups"-- Provided by publisher

Contents:
0 Contributing Chapter Editors
0 List of Illustrations
0 List of Tables
0 Foreword
0 Preface
0 Acknowledgments
0 Part I
1 What Is Lupus and How Is It Diagnosed?
2 Other Autoimmune Diseases
3 What Causes Lupus?
4 Meaning of All Those Test Results
0 Part II
5 How SLE Affects the Body Directly
6 Constitutional Symptoms
7 Musculoskeletal System
8 Skin and Mucous Membranes
9 Blood and Lymph Systems
10 Respiratory System
11 Heart and Blood Vessels
12 Urinary System
13 Nervous System
14 Exocrine Gland System
15 Digestive System
16 Eyes
17 Endocrine System
18 Reproductive System and Pregnancy
19 Prognosis, Special Populations, Healthcare Disparities
20 Lupus in Children and Adolescents
0 Part III
21 Heart Attacks, Strokes, and Blood Clots
22 Infections
23 Cancer
24 Osteoporosis
25 Avascular Necrosis of Bone
26 Adrenal Insufficiency
27 Fibromyalgia
28 Gastroesophageal Reflux and Stomach Ulcers
0 Part IV
29 General Treatment of Lupus
30 Antimalarials
31 Steroids
32 Immunosuppressants
33 Biologic Agents
34 Newest FDA-Approved Drugs for Lupus
35 Other Therapies for SLE
36 Prescription Pain Medicines
37 Future Treatments for SLE
38 Non-drug Therapies for Lupus
39 Complementary (Integrative) Medicine
0 Part V
40 Understanding your Symptoms
41 Becoming Pregnant, Breast-Feeding, Contraception, Menopause Treatment
42 Preparing for Surgery and Travel
43 Communicating with your Provider
44 Lupus Secrets Checklist
0 Index.

Contents:
1. Chemical and genetic diversity of Wolfberry
2. Immunoregulation and Lycium Barbarum
3. The antioxidant, anti-inflammatory, and antiapoptotic effects of Wolfberry in fatty liver disease
4. Effectts of Lycium barbarum on modulation of blood vessel and hemodynamics
5. Dermatologic uses and effects of Lycium barbarum
6. Lycium Barbarum and tumors in the gastrointestinal tract
7. Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum
8. Prosexual effects of Lycium Barbarum
9. Lycium Barbarum: neuroprotective effects in ischemic stroke
10. Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium Barbarum (Wolfberry)
11. Role of Lycium Barbarum extracts in retinal diseases
12. Allergenic sensitisation mediated by Wolfberry.

Summary: This book is a compact clinical introduction to Lyme borreliosis for physicians of all specialties who care for patients with suspected B. burgdorferi infection, whether in hospital or general practice. The book provides a great deal of practice-oriented information on symptomatology, diagnosis, treatment, and prophylaxis with a special emphasis on the situation in Europe. At the same time, it describes contemporary scientific knowledge in as much detail as is required in order to understand the pathogenetic relationships and their relevance to medical care. The authors are members of an interdisciplinary expert group of epidemiologists, biologists, microbiologists, and clinicians who have been working in the area of tick-borne diseases for many years. The personal experience of each of the authors, accumulated through their daily work with patients in special clinics or by confrontation with complicated questions in basic research, epidemiology, and laboratory diagnostics of Lyme borreliosis, represents an important mainstay of the book. Written from the perspective of clinical management and practical problem-solving, this topical monograph will assist clinicians in meeting diagnostic challenges and providing appropriate medical aid to patients with Lyme borreliosis.

Contents:
Chapter 1) Characteristics of Borrelia burgdorferi sensu lato
Chapter 2) Tick Ecology and Eco-epidemiology of Borrelia burgdorferi sensu lato
Chapter 3) Pathogenesis and Immune Defense
Chapter 4) The History, Epidemiology, Clinical Manifestations and Treatment of Lyme Borreliosis
Chapter 5) Special Aspects of Lyme Borreliosis in the United States
Chapter 6) Laboratory Diagnosis of Lyme Borreliosis
Chapter 7) Prophylactic Measures Including Future Perspectives
Chapter 8) Public Health Aspects of Lyme Borreliosis - The German Experience
Chapter 9) Other Ixodes-Borne Diseases.

Contents:
Fine-needle cytology : technical procedures and ancillary techniques
Lymph nodal structure and cytological patterns
Lymphadenitis and lymphadenopathy
Non-Hodgkin lymphoma
Hodgkin lymphoma
Paediatric lymphadenopathies
Immunodeficiency-associated lymphoproliferative disorders
Extranodal and deeply located lymphoproliferative processes
Metastases
Lymph node haematopoietic and histiocytic proliferatons and other lymphoid organs.

Summary: This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists.

Summary: Lymph node pathology is a complex and rapidly evolving field that requires integration of morphologic findings with a number of ancillary studies, as well as clinical information, to diagnose neoplastic and non-neoplastic hematopoietic disorders. Lymphomas are currently classified according to the 2016 revision of the World Health Organization (WHO) Classification, which emphasizes, and for some diagnoses mandates, the integration of clinical information in diagnostic decision making. Successful collaboration and teamwork between pathology and clinical specialties, especially hematology/oncology, are paramount for excellent patient care. In addition to diagnosis, pathology plays a significant role in lymphoma prognostication and contributes to patient management and follow-up. Lymph Node Pathology for Clinicians provides a concise overview of different entities in lymph node pathology with the primary audience being clinicians. This text is intended as a quick reference for a clinician to become familiar with pathologic aspects of lymphomas and the thought process of a pathologist. Particular consideration is given to relevant diagnostic and prognostic ancillary studies. Organized with an interdisciplinary approach for effective management of lymph node disorders, this book aims to educate our clinical colleagues on the most important aspects of lymph node pathology.

Contents:
Part I: Parasitology Including General Discussion
History
Epidemiology
Etiology
Lymphatic System
Pathology of Lymphatic Filariasis
Clinical Features
Investigations
Treatment and Prognosis
Prevention and Control
Antifilarial Drugs
Clinical Manifestations of Filariasis
Part II: Acute Clinical Manifestations
Filarial Fever
Acute Filarial Lymphangitis (AFL)
Acute Lymphadenitis (ADL)
Acute Dermatolymphangioadenitis (ADLA)
Filarial Funiculitis
Filarial Epididymo-orchitis
Filarial Cellulitis-abscess
Part III: Chronic Clinical Manifestations
Hydrocele of Tunica Vaginalis Testis
Chronic Lymphedema-elephantiasis
Chronic Lymphedema-elephantiasis of Lower Extremity
Chronic Lymphedema-elephantiasis of Scrotum
Chronic Lymphedema-elephantiasis of Penis
Chronic Lymphedema-elephantiasis of Upper Extremity
Filarial Manifestations of Female Breast
Chronic Lymphedema-elephantiasis of Vulva
Filarial Lymph Varix
Lymph Scrotum (Superficial Scrotal Lymphangiomatosis)
Chylous Manifestations (Syndromes) of Lymphatic Filariasis (Filarial Chylous Disease)
Chyluria
Chylous Ascites: Chyloperitoneum
Chylocele
Chylothorax
Chylous Diarrhea
Chylous Arthritis (Filarial Arthropathy)
Chylo-lymphatic Cyst
Eosinophilia in Lymphatic Filariasis
Filarial Hematuria
Very Rare Manifestations
Brugia Timori Filariasis
Summary.-References
Index.

Summary: Lymphatic Filariasis (LF) is a group of human and animal infectious diseases caused by nematode parasites of the order Filariidae. Often neglected, it is one of the oldest and the most debilitating tropical diseases (NTDs), transmitted from human to human by mosquitoes bites, particularly the brown black mosquito known as Culex quinquifasciatus. LF is a major public health problem in many parts of the tropics, especially India, which accounts for as much as 40% of total global cases. As a leading cause of permanent and long-term disability worldwide, the parasite infection imposes a severe physical and socioeconomic burden. The World Health Organization (WHO) estimates that 1.4 billion people live in high-risk areas - 120 million of which are already infected with LF, including 22 million children below the age of 15 and about 76 million who suffer from damaged lymphatic and renal systems. India has made great strides toward eliminating the disease, and these advances are of global significance. They include early diagnosis mechanisms, vaccine product development, detection of parasites in the vector, and studies on parasite evolution trends in nature as warning signals. Reports on the successes and failures are needed to enable measures to be taken to avoid disaster and ensure a smooth transition from endemicity in India to the elimination of lymphatic filariasis by 2020. This book, which gathers highly original contributions on various subjects related to lymphatic filariasis, discusses the latest scientific research that will help the nation to achieve this milestone. It also serves as a guide to many other countries struggling against this highly debilitating and incapacitating disease.

Contents:
Intro; Dedication; Foreword; Preface; Acknowledgement; Contents; About the Editor;
1: Epidemiology of Lymphatic Filariasis; 1.1 Introduction; 1.2 Filariasis Control Globally and in India; 1.3 Geographical Distribution; 1.4 Transmission Cycle; 1.5 Reservoir of Infection; 1.6 The Vectors; 1.7 Host Factors; 1.8 Environmental Factors; 1.9 Pathogenesis; 1.10 Clinical Features; 1.11 Infection/Disease Surveillance; 1.12 Current Control Strategy of Lymphatic Filariasis; 1.13 Conclusion; References;
2: Lymphatic Filariasis Elimination: Update for Mission Possible; 2.1 Introduction. 2.2 National Filaria Control Programme2.3 Organization Set-Up Recommended for NFCP; 2.4 Disease Endemicity; 2.5 Control Measures; 2.6 Genesis of Elimination of Lymphatic Filariasis (ELF); 2.7 National Goal and Strategy for ELF; 2.8 Mass Drug Administration; 2.9 Drug Compliance Assessment; 2.10 Transmission Assessment Survey (TAS); 2.11 Capacity Building; 2.12 Social Mobilization; 2.13 Morbidity Management; 2.14 Future Plan; References;
3: Next Step Lymphatic Filariasis Eradication: Current Status in the Development of a Vaccine Against Lymphatic Filariasis; 3.1 Introduction. 3.2 Development of Immunity Against LF3.2.1 Concept of "Endemic Normal" and Natural Immunity to LF; 3.2.2 The Need for Developing a Vaccine Against LF in the Human; 3.3 Developing a Vaccine Against LF; 3.3.1 Early Attempts to Develop a Vaccine Against LF; 3.3.2 Strategies for Selecting the Vaccine Antigens Against LF; 3.3.3 LF Parasites Modulate Host Immune Responses; 3.3.4 Animal Models and Limitations to Developing a Vaccine Against LF; 3.3.5 Screening Filariasis Genome to Identify Vaccine Candidates; 3.3.6 Improving the Vaccine Efficacy. 3.4 Future Prospects and Hurdles Before an LF Vaccine Becomes Available for the End Game to Control the Infection3.5 Concluding Remarks; References;
4: Progress in the Treatment and Control of Lymphatic Filariasis; 4.1 Introduction; 4.2 B. malayi Targets; 4.3 Wolbachia; 4.4 Wolbachia as Antifilarial Target; 4.5 Moxidectin; 4.6 Conclusion and Prospects; References;
5: Immunotechnological Advancements in Developing Vaccines for Lymphatic Filariasis; 5.1 Introduction; 5.2 Filarial Vaccines: Possible or Impossible?; 5.3 Challenges; 5.4 Animal Models for Vaccine Studies. 5.5 Milestones in LF Vaccination Studies5.5.1 Parasites and Crude Antigens; 5.5.2 Recombinant Filarial Vaccine Candidates; 5.6 Identification Methods for LF Vaccine Targets; 5.7 Different Categories of LF Vaccine Candidates; 5.7.1 Host-Parasite Interface: A Niche for Vaccine Candidates; 5.7.2 Metabolic Enzymes: Antioxidants; 5.8 Infective Stage-Specific Antigens; 5.8.1 Abundant Larval Transcripts (ALT): A Prototype L3 Stage Candidate Antigen; 5.8.2 Modern Approaches for LF Vaccine Development; 5.9 Immunomics: Identification of Immunogenic Proteins; 5.10 Peptide Vaccine Approach.

Summary: The second edition of this book serves as a central source of theoretical and practical knowledge to optimize the evaluation and treatment of patients with lymphedema. The book covers all aspects of the disease from anatomical and histological features to diagnosis as well as physical/medical and surgical management of the disease. Updated from the first edition to reflect the substantial progress in diagnostics, medical care and surgical intervention for this patient population, this volume has been reorganized to meet today's practice requirements. It addresses the challenges faced by clinicians in the management of chronic lymphedema enabling them to meet the medical needs of this large patient community. Edited by world leaders in Vascular Medicine and Surgery, this comprehensive volume provides clear, concise background and recommendations in an easy-to-use format. It is a valuable reference tool for clinical practitioners (physicians/nurse practitioners/technicians) who wish to deliver state-of-the-art health care to their patients with lymphatic and venous disorders.

Contents:
Section I
Introduction
1. General Considerations
2. Etiology and Classification of Lymphatic Disorders
3. Hereditary and Familial Lymphedemas.-Section II
Embryology, Anatomy, & Histology
4. Embryology of the Lymphatic System and Lymphangiogenesis
5. Anatomy of the Lymphatic System and Its Structural Disorders in Lymphoedema
Section III
Physiology, Pathophysiology and Lymphodynamic
6. General Overview
7. Lymphodynamics
8. Physiology- Lymph Flow
9. Biomechanics of the Lymphatic Circulation
10. Pathology & Histochemistry
11. Lymph Formation and Composition
Section IV
Clinical Diagnosis
12. General Overview
13. Lymphedema Epidemiology.-14. Clinical Staging
15. Combined Clinical and Laboratory (Lymphoscintigraphic) Staging
16. Early Diagnosis in the Latent Phase
17. Cutaneous Manifestations of Edema
18. The Diagnosis of Edema and Its Pathogenesis
19. Differential Diagnosis: Venous Edema
20. Differential Diagnosis: Lipedema.-Section V
Laboratory/Imaging Diagnosis
21. General Guidelines
22. Radionuclide Lymphoscintigraphy
23. Duplex ultrasonography
24. Oil Contrast Lymphangiography
25. Microscopic Lymphoangiography
26. Near Infrared Fluorescent Lymphography
27. MR Lymphangiography
28. Combined role of the lymphoscintigraphy, Xray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease
29. Alternative Assessment & Measurement Tools
Section VI
Physical and Medical Management
30. General Overview
31. Complete Decongestive Physiotherapy
32. Decongestive Lymphatic Therapy
33. Compression Therapy
34. Intermittent Pneumatic Compression Therapy
35. Other contemporary Treatment Modalities
36. Medical Treatment Options
37. Diagnosis and Managment of Infection in Lymphedema
38. The Prospect for Genetic and Growth Factor Therapy
39. Adherence and Quality of Life
40. Lymphedema within the Healthcare System
Section VII
Practical issues in the Physiotherapeutic Approach to Lymphedema
41. Lower Limb Lymphedema
42. Upper Limb Lymphedema
43. Head, Face and Neck Lymphedema
44. Genital Lymphedema
Section VIII
Surgical Treatment
Reconstructive Surgery
45. General Overview
46. Principles of Patient Selection for Surgical Management of Lymphedema
47. Lymphatic-Venous Derivative and Reconstructive Microsurgery
48. Lymphatic-Lymphatic Reconstructive Microsurgery
49. Lymph Node-Venous Microvascular Reconstructive Surgery: Filariasis Lymphedema
50. Vascularized Lymph Node Transfer for the Treatment of Lymphedema
51. A Combined Microsurgical Reconstruction Approach for Lymphedema
52. Current Dilemmas and Controversy in Reconstructive Surgery for Lymphedema
53. Future Prospects in Lymphatic Reconstructive Surgery
Section IX
Surgical treatment: Excisional and Debulking Techniques
54. General Principles
55. Contemporary Indications and Controversies in Excisional Surgery
56. From Lymph to Fat
Liposuction as a Treatment for Complete Reduction of Lymphedema
57. Surgical Management of Lipedema
Section X
Congenital Vascular Malformation with Lymphatic Involvement
58. General Overview
59. Primary lymphedema and Lymphatic Malformation
60. Molecular Genetics of Lymphatic and Complex Vascular Malformations
61. Syndromic Lymphedema and Complex Vascular Malformations with Lymphatic Involvement
62. An Atlas of Neonatal and Infantile Lymphedema
Section XII
Management of Chyle Reflux and Effusions.-63. Pathophysiology and Medical Management of Chylous Disorders
64. Surgical Management of Chylous Reflux and Effusions
65. Endovascular Catheter-based Management of Chylous Effusions.-Section XII
Lymphatic Filariasis
66. Epidemiology
67. Etiology & Pathophysiology
68. Clinical Overview- Diagnosis and Management
Section XIII
Oncology and Lymphedema
69. Breast Cancer.-70. Lower Extremity Cancers
71. Radiation Considerations
Section
XIV
Phlebolymphedema
72. Diagnosis and Management of Primary Phlebolymphedema
73. Diagnosis and Management of Secondary Phlebolymphedema
74. Management of Phlebolymphedema Ulcer.

Summary: "Lymphedema: Complete Surgical and Medical Management is one of the first books to cover the state of the field, encompassing both surgical and nonsurgical treatments. It is divided into several areas: anatomy, physiology, and lymphangiogenesis; pathophysiology and clinical presentation; diagnosis; treatment - including surgical and pharmacologic therapy; and research and future directions. Building on this foundation, the text discusses diagnostic modalities, biomarkers, and differential lymph node mapping and clinical staging. It includes the history of lymphedema treatment and an overview of various past and present treatments in India and China, then explores pharmacological options, excisional approaches, liposuction, and venous implantation methods. Detailed presentations of lymphatic grafts and surgical treatments round out the coverage. The book closes with a discussion on animal models, improving patient outcomes, and the potential use of stem cells in lymphedema management. Using a consistent format throughout, the book includes more than 500 illustrations, many in color. A DVD with practical surgical videos is included. With US, European, and Asian-Pacific contributing experts, this book presents a truly global approach"--Publisher's description.

Summary: This volume is a clinically-oriented book that can be used for patient care, teaching, or research. It covers the entire field of lymphedema, including both primary and secondary disease, as well as all diagnostic and treatment modalities. The text begins with a foundation for the condition, including its pathophysiology, epidemiology, and morbidity. Next, the classification of lymphedema is covered which is the template for accurate diagnosis. Clinical, radiological, and differential diagnosis of lymphedema is also reviewed. Finally, conservative and operative management is presented, including both physiologic and excisional procedures. Lymphedema: Presentation, Diagnosis, and Treatment provides a comprehensive, easy-to-read reference for any health care provider managing a patient with lymphedema. The text is clinically-focused, evidence-based, and practical. The reader, regardless of his/her level of training or specialty, will be able to adequately treat a patient with lymphedema using this resource. To facilitate its use in clinical settings, the book was designed to be portable. In addition, diagnostic and treatment algorithms are included to further simplify the management of these patients. Patient images are presented throughout the text to illustrate the clinical care of lymphedema. All chapters are written by experts in the field, and contain the most current information on the topic.

Contents:
Section 1: Overview of Lymphedema
The Lymphatic System
Pathophysiology of Lymphedema
Genetic Causes of Lymphedema
Epidemiology and Morbidity of Lymphedema
Myths Associated with Lymphedema
The Lymphedema Center and Multidisciplinary Management
Section 2: Classification of Lymphedema
Primary Lymphedema
Secondary Lymphedema
Obesity-Induced Lymphedema
Section 3: Diagnosis of Lymphedema
History and Physical Examination
Volume Measurements and Follow-Up
Bioelectrical Impedance Spectroscopy for the Assessment of Lymphedema: Principles and Practice
Assessing Free and Bound Water in Skin at 300 MHz Using Tissue Dielectric Constant Measurements with the MoistureMeterD
Conventional Imaging Modalities for the Diagnosis of Lymphedema
Lymphoscintigraphy and Other Imaging Methods
Differential Diagnosis of Lymphedema
Section 4: Non-Operative Management of Lymphedema
Activities of Daily Living
Controlled Compression Therapy and Compression Garments
Complex Decongestive Therapy
Pneumatic Compression
Section 5: Operative Management of Lymphedema
Uncommon Procedures for Lymphedema
Lymphatic Vessel Transplantation
Lymphatic-Venous Anastomosis
Lymph Node Transfer to Proximal Extremity
Lymph Node Transfer to Distal Extremity
Charles Procedure
Staged Skin and Subcutaneous Excision
Suction-Assisted Lipectomy
Treatment of Lymphocele
Genital Lymphedema.

Summary: This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the diseases manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

Contents:
1 Molecular mechanism of Lynch syndrome
2 Clinical features of Lynch syndrome
3 Pathology of Lynch syndrome-associated tumors
4 Immunohistochemistry for mismatch repair proteins
5 Genetic analysis for Lynch syndrome
6 Lynch syndrome-associated gynecological malignancies
7 Lynch syndrome-associated urological malignancies
8 Screening for Lynch syndrome
9 Surveillance Colonoscopy for Lynch Syndrome Patients
10 Surgical approach for colorectal cancer in patients with Lynch syndrome
11 Immunotherapy for Lynch syndrome patients
12 Chemoprevention for Lynch syndrome-associated malignancies
13 International collaboration for Lynch syndrome.