BookAhmed El-Hashash.
Summary: This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.
Contents:
Intro; Dedication; Foreword; Foreword; Preface; Acknowledgments; Contents; About the Author; List of Figures; Introduction;
Chapter 1: Brief Overview of the Human Respiratory System Structure and Development; 1.1 Brief Overview of the Structure of Human Respiratory System; 1.2 Brief Overview of the Development of Human Respiratory System;
Chapter 2: Diversity of Lung Stem and Progenitor Cell Types; 2.1 Alveolar Epithelial Stem and Progenitor Cells; 2.1.1 Localization and Characterization; 2.1.2 The Repair and Regeneration Capacities and Mechanisms. 2.2 Tracheal and Bronchial Epithelial Stem and Progenitor Cells2.2.1 Localization and Characterization; 2.2.2 The Repair and Regeneration Capacities and Mechanisms; 2.3 Lung Mesenchymal Stem and Progenitor Cells; 2.3.1 Lung Vascular Endothelial Stem and Progenitor Cells; 2.3.2 Lung Smooth Muscle Stem and Progenitor Cells; 2.3.3 The Repair and Regeneration Capacities;
Chapter 3: Signals and Molecular Mechanisms Controlling Lung Stem/Progenitor Cell Development and Behavior; 3.1 Signals and Genes Regulating General Lung Cell Growth and Development. 3.2 Signals and Genes Regulating Lung Stem/Progenitor Cell Behavior: The Self-Renewing and Differentiation3.2.1 Role of Transcription Factors; 3.2.2 Role of Growth Factors; 3.2.3 Role of Micro-RNAs (miRNAs); 3.2.4 Role of Other Factors and Signal Molecules; 3.2.5 Role of the Epigenetic Factors; 3.3 Regulatory Signal Mechanisms of Stem and Progenitor Cells During Lung Repair and Regeneration;
Chapter 4: Signals and Molecular Mechanisms Regulating Stem Cell Behavior in Other Systems (e.g., Hematopoietic Stem Cells); 4.1 Hierarchy and Heterogeneity of Hematopoietic Stem and Progenitor Cells.
Chapter 5: Mode of Cell Division as a Regulatory Mechanism for Lung Stem Cell Behavior Compared to Other Systems5.1 Asymmetrical Divisions of Stem Cells in Different Systems; 5.1.1 Intestinal Stem and Progenitor Cells of Drosophila; 5.1.2 Hematopoietic Stem and Progenitor Cells; 5.1.3 Muscle Stem and Progenitor Cells; 5.1.4 Epidermal Stem and Progenitor Cells; 5.1.5 Neural Stem and Progenitor Cells; 5.2 Asymmetrical Divisions of the Lung Epithelial Stem and Progenitor Cells; 5.2.1 Numb as a Key Regulator of Asymmetric Cell Division and Cell Fate in the Lung.