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  • Google Books
    par Edouard Dulaurier.
    t. 1. Chronologie technique.
    Also available: Print – v. 1, 1859.
  • 2010 Springer
    John F. Atkins, Raymond F. Gesteland, editors.
    Part I. Redefinition -- 1. Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes / Vadim N. Gladyshev and Dolph L. Hatfield -- 2. Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors / Marla J. Berry and Michael T. Howard -- 3. Translation of UAG as Pyrrolysine / Joseph A. Krzycki -- 4. Specification of Standard Amino Acids by Stop Codons / Olivier Namy and Jean-Pierre Rousset -- 5. Ribosome “Skipping”: “Stop-Carry On” or “StopGo” Translation / Jeremy D. Brown and Martin D. Ryan -- 6. Recoding Therapies for Genetic Diseases / Kim M. Keeling and David M. Bedwell -- Part II. Frameshifting - Redirection of Linear Readout -- 7. Pseudoknot-Dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models / Ian Brierley, Robert J.C. Gilbert, and Simon Pennell -- 8. Programmed -1 Ribosomal Frameshift in the Human Immunodeficiency Virus of Type 1 / Léa Brakier-Gingras and Dominic Dulude -- 9. Ribosomal Frameshifting in Decoding Plant Viral RNAs / W. Allen Miller and David P. Giedroc -- 10. Programmed Frameshifting in Budding Yeast / Philip J. Farabaugh -- 11. Recoding in Bacteriophages / Roger W. Hendrix -- 12. Programmed Ribosomal -1 Frameshifting as a Tradition: The Bacterial Transposable Elements of the IS3 Family / Olivier Fayet and Marie-Françoise Prère -- 13. Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals / Ivaylo P. Ivanov and Senya Matsufuji -- 14. Sequences Promoting Recoding Are Singular Genomic Elements / Pavel V. Baranov and Olga Gurvich -- 15. Mutants That Affect Recoding / Jonathan D. Dinman and Michael O'Connor -- 16. The E Site and Its Importance for Improving Accuracy and Preventing Frameshifts / Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, and Knud H. Nierhaus -- Part III. Discontiguity -- 17. Translational Bypassing - Peptidyl-tRNA Re-pairing at Non-overlapping Sites / Norma M. Wills -- 18. trans-Translation / Kenneth C. Keiler and Dennis M. Lee -- Part IV. Transcription Slippage -- 19. Transcript Slippage and Recoding / Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, and William T. McAllister -- Part V. Appendix -- 20. Computational Resources for Studying Recoding / Andrew E. Firth, Michaël Bekaert, and Pavel V. Baranov.
  • pt. A-B, 2003. ScienceDirect
    pt. B ScienceDirect
    edited by Yuan C. Lee, Reiko T. Lee.
    Also available: Print – pt. A-B, 2003.
  • 2012
    Christina Meyer.
    The adaptive immune system is composed of [alpha beta] T cells, [gamma delta] T cells, and B cells, all of which express diverse rearranged antigen receptors and have been conserved together through evolution. [gamma delta] T cells make up the minority of circulating T cells and perform many of the same effector functions as [alpha beta] T cells, including cytotoxic functions and the production of cytokines like IL-17, IFN-[gamma], and IL-4. However, the conservation of [gamma delta] T cells suggests that they fill a non-redundant role in the adaptive immune system. Because their functions overlap, it is likely that [gamma delta] T cells are distinctive from [alpha beta] T cells in the way they are triggered by antigen. These antigenic triggers of [gamma delta] T cells remain poorly defined, but a more thorough knowledge of this repertoire will enhance understanding of the role of [gamma delta] T cells in the immune response. The identification of new [gamma delta] T cell antigens was undertaken, resulting in the discovery of hapten small molecule [gamma delta] T cell ligands and the identification of a diverse group of additional candidate [gamma delta] T cell ligands. With the discovery that [gamma delta] T cell receptors can recognize small molecules in addition to their known large protein ligands, it is clear that [gamma delta] T cells fill a unique role in the adaptive immune system is solidified with a broad capacity for antigen recognition along with all the functionality of T cells, and are uniquely situated to function together with [alpha beta] T cells and B cells in a concerted antigen-specific response.
  • 2014 ScienceDirect
    by Leon Chaitow, Christopher Gilbert, Dinah Bradley.
    This book is intended to help practitioners understand the causes and effects of disordered breathing and to provide strategies and protocols to help restore normal function. Fully updated throughout, this volume has been completely revised to guide the practitioner in the recognition of breathing pattern disorders and presents the latest research findings relating to the condition including a range of completely new techniques - many from an international perspective - to help restore and maintain normal functionality. Video clips on an associated website presents practical examples of the breathing techniques discussed in the book. Carefully prepared by a global team of renowned experts under the guidance of Leon Chaitow Focuses on practical, validated, and clinically relevant information Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Contains clinical cases to ensure full comprehension of the topics explored Suitable for physiotherapists, manual therapists, physical therapists, osteopaths, osteopathic physicians and chiropractors, massage therapists, Pilates and yoga teachers & therapists, Tai chi and Feldenkrais practitioners, athletic coaches and voice-coaches.
  • 2011
    Wang Rui.
    How the human brain processes phonemes has been a subject of interest for linguists and neuroscientists for a long time. Electroencephalography (EEG) offers a promising approach to observe neural activities of phoneme processing in the brain, thanks to its high temporal resolution, low cost and noninvasiveness. The studies on Mismatch Negativity (MMN) effects in EEG activities in the 1990s suggested the existence of a language-specific central phoneme representation in the brain. Recent findings using magnetoencephalograph (MEG) also suggested that the brain encodes the complex acoustic-phonetic information of speech into the representations of phonological features before the lexical information is retrieved. However, very little success has yet been reported in classifying the brain activities associated with phoneme processing. In my work, I proposed a classification framework which incorporates Principal Components Analysis (PCA), cross-validation and support vector machine (SVM) methods. The initial classification rates were not very good. Progress was made by using bootstrap aggregation (Bagging) scheme and introducing phase calculations. To calculate phase, I computed the Discrete Fourier Transform (DFT) of the original time-domain signal and kept the angles of the finite sample of frequencies. The resulting EEG spectral representation contains only the phase and frequency information and ignores the amplitudes. Using this method, the accurate rate of classifying averaged test samples of eight consonants improved from 41% to 51%. Furthermore, the qualitative analysis of the similarities between the EEG representations, derived from the confusion matrices, illustrates the invariance of brain and perceptual representation of phonemes. For brain and perceptual representation of consonants, voicing is the most distinguishable feature among voicing, continuant and place of articulation. And the feature vowel-height is more robust than vowel-backness in both brain and perceptual representation of vowels. By extending and further refining these methods, it is likely significant classification of other phonemes and features can be made.
  • 2012 Springer Protocols
    edited by Graeme L. Conn.
    Purification of RNA expressed in vivo inserted in a tRNA scaffold / Luc Ponchon and Frederic Dardel -- Selective RNase H cleavage of target RNAs from a tRNA scaffold / Luc Ponchon [and others] -- Preparation of long templates for RNA in vitro transcription by recursive PCR / Jessica C. Bowman [and others] -- General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE / Jo L. Linpinsel and Graeme L. Conn -- Preparation of short RNA by in vitro transcription / Cheng Lu and Pingwei Li -- Native RNA purification by gel filtration chromatography / Evan P. Booy, Hui Meng, and Sean A. McKenna -- Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5ʹ and 3ʹ ends / Johanna M. Avis, Graeme L. Conn, and Scott C. Walker -- Trans-acting antigenomic HDV ribozyme for production of in vitro transcripts with homogenous 3ʹ ends / Milena Szafraniec [and others] -- Rapid preparation of RNA samples using DNA-affinity chromatography and DNAzyme methods / Hae-Kap Cheong, Eunha Hwang, and Chaejoon Cheong -- Preparation of lN-GST fusion protein for affinity immobilization of RNA / Genevieve Di Tomasso [and others] -- Affinity purification of RNA using an ARiBo tag / Genevieve Di Tomasso [and others] -- Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments / Virginia K. Vachon and Graeme L. Conn -- In vitro transcription of modified RNAs / Stephanie L. Moon and Jeffrey Wilusz -- End-labeling oligonucleotides with chemical tags after synthesis / N. Ruth Zearfoss and Sean P. Ryder -- High-purity enzymatic synthesis of site-specifically modified tRNA / Ya-Ming Hou -- Se-derivatized RNAs for x-ray crystallography / Lina Lin and Zhen Huang -- Biosynthetic preparation of 13C/15N-labeled rNTPs for high-resolution NMR studies of RNAs / Luigi Martino and Maria R. Conte -- Preparative separation of ribonucleoside monophosphates by ion-pair reverse-phase HPLC / Pierre Dagenais and Pascale Legault -- Splint ligation of RNA with T4 DNA ligase / Christopher J. Kershaw and Raymond T. O'Keefe.
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1979
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman, Kivie Moldave.
    Also available: Print – 1983
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman, Kivie Moldave.
    Also available: Print – 1983
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1992
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1993
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1993
  • 2012 Springer Protocols
    edited by Argelia Lorence.
    Using folding promoting agents in recombinant protein production : a review / Beatrix Fahnert -- Routine identity confirmation of recombinant proteins by MALDI-TOF mass spectrometry / Brett J. Savary and Prasanna Vasu -- A matter of packaging : influence of nucleosome positioning on heterologous gene expression / María de la Cruz Muñoz-Centeno, Gonzalo Millán-Zambrano, and Sebastián Chávez -- Tools of the trade : developing antibody-based detection capabilities for recombinant proteins / Maureen C. Dolan [and others] -- Heat-shock protein fusion vectors for improved expression of soluble recombinant proteins in Escherichia coli / Christos A. Kyratsous and Christos A. Panagiotidis -- The use of a flagellar export signal for the secretion of recombinant proteins in salmonella / Ferenc Vonderviszt [and others] -- Optimization of purification protocols based on the step-by-step monitoring of the protein aggregates in soluble fractions / Ario de Marco -- Heterologous protein expression by Lactococcus lactis / Julio Villator-Hernández [and others] -- An extended suite of genetic tools for use in bacteria of the halomonadaceae : an overview / Montserrat Argandoña [and others] -- Regulated recombinant protein production in the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Valentina Rippa [and others] -- A novel strategy for the construction of genomic mutants of the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Maria Giuliani [and others] -- A new bacterial co-expression system for over-expressing soluble protein and validating protein-protein interaction / Jumei Zeng and Zheng-Guo He -- Heterologous high-level gene expression in the photosynthetic bacterium Rhodobacter capsulatus / Nadine Katzke [and others] -- Plasmid DNA production for therapeutic applications / Alvaro R. Lara and Octavio T. Ramírez -- Recombinant protein production in the eukaryotic protozoan parasite Leishmania tarentolae : a review / Tomoaki Niimi -- Expression of multisubunit proteins in Leishmania tarentolae / Marisa Sugino and Tomoaki Niimi -- Recombinant protein production in yeasts / Diethard Mattanovich [and others] -- Yeasts as a tool for heterologous gene expression / Raja Mokdad-Gargouri [and others] -- The Cre/Lox system : a practical tool to efficiently eliminate selectable markers in fungal endophytes / Simona Florea [and others] -- Aptamer-regulated expression of essential genes in yeast / Beatrix Suess [and others] -- Cloning and expression of hemicellulases from Aspergillus nidulans in Pichia pastoris / Prasanna Vasu, Stefan Bauer, and Brett J. Savary -- A thiamine-regulatable epitope-tagged protein expression system in fission yeast / Tiina Tamm -- Heterologous gene expression by chromosomal integration in fission yeast / Akihisa Matsuyama and Minoru Yoshida -- Genetic engineering of industrial strains of Saccharomyces cerevisiae / Sylvie le Borgne -- Recombinant protein production in plants : challenges and solutions / Elizabeth E. Hood and Deborah V. Vicuna Requesens -- A novel plant cell bioproduction platform for high-yield secretion of recombinant proteins / Jianfeng Xu and Marcia J. Kieliszewski -- Super-promoter :TEV, a powerful gene expression system for tobacco hairy roots / Luis Ñopo [and others] -- Bioseparation of recombinant proteins from plant extract with hydrophobin fusion technology / Jussi J. Joensuu [and others] -- Quality assessment of recombinant proteins produced in plants / Giuliana Medrano [and others] -- Cell-free protein synthesis as a promising expression system for recombinant proteins / Xumeng Ge and Jianfeng Xu -- The use of bacterial artificial chromosomes for recombinant protein production in mammalian cell lines / Leander Blaas [and others] -- Engineering the chaperone network of CHO cells for optimal recombinant protein production and authenticity / Lyne Jossé, C. Mark Smales, and Mick F. Tuite -- High-throughput baculovirus expression in insect cells / Richard B. Hitchman, Robert D. Possee, and Linda A. King -- Recombinant protein expression in milk of livestock species / Zsuzsanna Bösze and László Hiripi.
  • 2012 Springer Protocols
    edited by Roslyn M. Bill.
    Optimising yeast as a host for recombinant protein production (review) / Nicklas Bonander and Roslyn M. Bill -- Which yeast species shall I choose? : Saccharomyces cerevisiae versus Pichia pastoris (review) / Richard A.J. Darby [and others] -- Preparation of Pichia pastoris expression plasmids / Christel Logez [and others] -- Preparation of Saccharomyces cerevisiae expression plasmids / David Drew and Hyun Kim -- Codon optimisation for heterologous gene expression in yeast / Kristina Hedfalk -- Yeast transformation to generate high-yielding clones / Mohammed Jamshad and Richard A.J. Darby -- Screening for high-yielding Pichia pastoris clones : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Screening for high-yielding Saccharomyces cerevisiae clones: using a green fluorescent protein fusion strategy in the production of membrane proteins / David Drew and Hyun Kim -- The effect of antifoam addition on protein production yields / Sarah J. Routledge and Roslyn M. Bill -- Setting up a bioreactor for recombinant protein production in yeast / Sarah J. Routlledge and Michelle Clare -- The implementation of a design of experiments strategy to increase recombinant protein yields in yeast (review) / Nagamani Bora [and others] -- Online analysis and process control in recombinant protein production (review) / Shane M. Palmer and Edmund R.S. Kunji -- Monitoring the biomass accumulation of recombinant yeast cultures : offline estimations of dry cell mass and cell counts / Shane M. Palmer and Edmund R.S. Kunji -- Online monitoring of biomass accumulation in recombinant yeast cultures / Shane M. Palmer and Edmund R.S. Kunji -- Optimising Pichia pastoris induction / Zharain Bawa and Richard A.J. Darby -- Optimizing Saccharomyces cerevisiae induction regimes / David Drew and Hyun Kim -- Large-scale production of membrane proteins in Pichia pastoris : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Large-scale production of secreted proteins in Pichia pastoris / Nagamani Bora -- Disruption of yeast cells to isolate recombinant proteins / Mohammed Jamshad and Richard A.J. Darby.
  • 2009 Springer Protocols
    edited by Loïc Faye and Véronique Gomord.
    From Neanderthal to nanobiotech : from plant potions to pharming with plant factories / Christophe Sourrouille ... [et al.] -- Cowpea mosaic virus-based systems for the expression of antigens and antibodies in plants / Frank Sainsbury, Li Liu, and George P. Lomonossoff -- Transient expression of antibodies in plants using syringe agroinfiltration / Marc-André D'Aoust ... [et al.] -- Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants / Giuliana Medrano ... [et al.] -- Production and localization of recombinant pharmaceuticals in transgenic seeds / Thomas Rademacher, Elsa Arcalis, and Eva Stoger -- Production of antibody fragments in Arabidopsis seeds / Bart Van Droogenbroeck, Kirsten De Wilde, and Ann Depicker -- Production of plantibodies in Nicotiana plants / Marta Ayala ... [et al.] -- Physcomitrella patens : a non-vascular plant for recombinant protein production / David Liénard and Fabien Nogué -- Production of recombinant proteins in suspension-cultured plant cells / Carole Plasson ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals : protocols for expression, purification, or oral delivery and functional evaluation / N. Dolendro Singh, Yi Ding, and Henry Daniell -- Protein body induction : a new tool to produce and recover recombinant proteins in plants / Margarita Torrent, Imma Llop-Tous, and M. Dolors Ludevid -- A case study for plant-made pharmaceuticals comparing different plant expression and production systems / Guy Vancanneyt ... [et al.] -- Glycosylation of antibody therapeutics : optimisation for purpose / Roy Jefferis -- N-glycosylation of plant recombinant pharmaceuticals / Muriel Bardor ... [et al.] -- Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts / Meriem Benchabane ... [et al.] -- Strategies for improving vaccine antigens expression in transgenic plants : fusion to carrier sequences / Jose M. Escribano and Daniel M. Perez-Filgueira -- Immunomodulation of plant function by in vitro selected single-chain Fv intrabodies / Manfred Gahrtz and Udo Conrad -- On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI-TOF MS / Amine M. Badri ... [et al.] -- Assessing the risk of undesirable immunogenicity/allergenicity of plant-derived therapeutic proteins / Paul D. Chamberlain -- Biosafety, risk assessment, and regulation of plant-made pharmaceuticals / Penelope A.C. Sparrow and Richard M. Twyman.
  • 2008 Springer
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    "Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Anibidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume."--Jacket.
  • 2008 Springer
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm - in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillar.
  • 2007
    guest editors: Robert H. Dworkin, Robert W. Johnson, Judith Breuer ... [and others].
  • 2007
  • CDC
  • 2006
    Frederic Lawrence Holmes ; edited by William C. Summers.
    Status: Not Checked OutLane Catalog Record
    Classical mendelian genetics -- Genetics and the phage biologists -- The physicist becomes a phage biologist -- To Paris and back -- Teaching and research at Purdue -- Entering the rII region -- Crossing into the fine structure -- Is gene a dirty word? -- The survival of the "gene".
  • 2014 ScienceDirect
    edited by Ron Vale ; contributors Anna Akhmanova [and seven nine others].
    Actin filament dynamics using microfluidics -- Bacterial actin-like proteins: purification and characterization of self-assembly properties -- Quantitative analysis of microtubule self-assembly kinetics and tip structure -- Biochemical reconstitution of the WAVE regulatory complex -- Rotational movement of formins evaluated by using single-molecule fluorescence polarization -- Single-molecule studies of actin assembly and disassembly factors -- Assaying microtubule nucleation of the [gamma]-Tubulin ring complex -- Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins -- Generation of differentially modified microtubules using In Vitro enzymatic approaches -- Engineering defined motor ensembles with DNA origami -- Construction and analyses of elastically coupled multiple-motor systems -- Reconstitution of cortical dynein function -- Reconstitution of microtubule-dependent organnelle transport -- Reconstituting the motility of isolated intracellular cargoes -- Reconstitution of contractile actomyosin arrays -- Directed actin assembly and motility -- In Vitro reconstitution of dynamic microtubules interacting with actin filament networks -- Measuring kinetochore-microtubule interaction In Vitro -- Micropattern-guided assembly of overlapping pairs of dynamic microtubules -- WAVE regulatory complex activation -- Dissecting principles governing actin assembly using yeast extracts -- Xenopus egg ctyoplasm with intact actin -- Glycogen-supplemented mitotic cytosol for analyzing xenopus egg microtubule organization -- Spindle assembly on immmobilized chromatin micropatterns.
  • ScienceDirect
    edited by James E. Rothman.
    Also available: Print – 1992
  • 2013
    Murray C. Meikle.
    "The two world wars played an important role in the evolution of plastic and maxillofacial surgery in the first half of the 20th century. This book is about four of the key figures involved. Sir Harold Gillies and Sir Archibald McIndoe were born in Dunedin; McIndoe and Rainsford Mowlem studied medicine at the University of Otago Medical School, and Henry Pickerill was foundation Dean of the University of Otago Dental School. The author describes how these surgeons revolutionised plastic surgery and the treatment of facial trauma, working on soldiers, fighter pilots and civilians disfigured by bombs, shrapnel and burns. Eventually Gillies et al. were supported by a vast surgical enterprise that included surgeons, dentists, anaesthetists, artists and photographers, nurses and orderlies. The text is fully illustrated with photos, drawings and case notes by the surgeons and war artists at military hospitals at Boulogne-sur-Mer, Aldershot and Sidcup in the First World War, and civilian hospitals at East Grinstead, Basingstoke and Hill End in the Second. The book includes a DVD of Rainsford Mowlem performing a variety of plastic operations in 1945. This book is a must for anyone interested in the history of medicine and the treatment of casualties in the two world wars"--From publisher.
  • 2007 CRCnetBASE
    edited by Trevor R. Hodkinson, John A.N. Parnell.
    section A. Introduction and general context -- section B. Reconstructing and using the tree of life -- section C. Taxonomy and systematics of species rich groups (case studies).
  • 2011 Springer
    Petr Suchomel, Ondřej Choutka ; with contributions by Jan Hradil ... [et al.].
    Surgical anatomy -- Biomechanical remarks -- Special radiology -- Surgical approaches -- Basic principles of reconstruction techniques -- Specific reconstruction techniques of upper cervical spine and craniovertebral junction -- Virtual and real time navigational techniques -- Traumatic atlantooccipital dislocation (AOD) -- Occipital condyle fractures -- Atlas fractures -- Odontoid process fractures -- Fractures of the ring of axis (hangman type fractures) -- Miscellaneous C2 fractures -- Multiple fractures of axis and atlas-axis fracture combinations -- Acute traumatic atlantoasial dislocation (AAD) in adults -- Posttraumatic deformity -- Non-specific inflammation -- Rheumatoid arthritis -- Tumors -- Congenital and developmental abnormalities -- Degenerative disorders -- Surgical failures.
  • 2010 ClinicalKey
    Mark S. Myerson.
    World-renowned surgeon Dr. Mark S. Myerson returns with a Second Edition of Reconstructive Foot and Ankle Surgery. This surgical technique reference delivers step-by-step guidance on the essential elements of complex foot and ankle surgery and is packed with full-color illustrations, pearls, and pitfalls. New chapters focus on the complications management of complications, aimed to help you select the right procedure for challenging conditions to ensure optimal outcomes. Learn from one of the very best - world-renowned surgeon Dr. Mark S. Myerson shares his innovative approaches to the reconstructive surgical techniques and complications management most frequently seen in practice. Quickly reference essential topics with a templated, focused format emphasizing procedures rather than basic science.
  • 2015 Springer
    Salah Rubayi ; with contributions by Burl R. Wagenheim and Alicia Mcleland.
  • 2016 Thieme-Connect
    Matthew M. Hanasono, Geoffrey L. Robb, Roman J. Skoracki, Peirong Yu.
  • 2013 Springer
    Andrew P. Zbar, Robert D. Madoff, Steven Wexner, editors.
    Reconstructive Surgery of the Rectum, Anus and Perineum provides the reader with a didactic discussion of complex problems which require re-operative surgery; including details of preoperative investigation, postoperative follow-up and a detailed operative approach. This comprehensive and detailed text uses a formulated algorithm approach to these complicated cases using operative photographs and composite explanatory line drawings which complement 'how-to' guides in describing the operative technical tips and pitfalls from experienced commentators. Reconstructive Surgery of the Rectum, Anus and Perineum, is written by leading world experts in the field of colorectal surgery and is a valuable and timely resource for colorectal surgeons and colorectal trainees alike. In addition, general surgeons will be interested in the specialist nature of dealing with difficult colorectal complications dealt with in this unique textbook.
  • 2008 Springer
    edited by Bradley J. Adams and John E. Byrd.
  • 2010 Springer
    edited by Brian G. Czito, Christopher G. Willett.
  • 2005 Springer
    [edited by] Gian Gaetano Delaini ; foreword by R.J. Nicholls.
  • 2013 Springer
    Nicolò de Manzini, editor ; forewords by Gianluigi Melotti, Christiam Meyer.
    This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
  • 2005 Springer
    M.W. Büchler, R.J. Heald, B. Ulrich, J. Weitz (eds.).
    Also available: Print – 2005
  • 2008 Springer
    Donato F. Altomare, Filippo Pucciani (eds.).
  • 2016 Springer
    Gregory W. Randolph, editor.
  • 2015 Springer
    Helena M. Tabery.
    This book on the morphology of corneal surface changes in recurrent erosion syndrome and epithelial edema presents high-magnification images captured in vivo by the method of non-contact photomicrography. Part I of the book, on recurrent erosion syndrome, displays images covering a broad spectrum of epithelial changes, including manifestations of the ongoing underlying pathological process and epithelial activity aimed at elimination of abnormal elements and repair. The dynamics of the interplay between these opposing forces are captured in sequential photographs that are invaluable for interpretation. Case reports illustrate typical features of the disease and document the variability of symptoms and findings in the same individual over time. Also included are images of the appearance and dynamics of corneal stromal infiltrates, a rare but potentially sight-threatening complication. Part II of the book demonstrates typical features of corneal epithelial edema and also covers the occasional contemporaneous occurrence, and dynamics, of various phenomena indistinguishable from those commonly seen in recurrent erosion syndrome. Again, informative case reports are included. The in vivo images displayed in this book, obtained at a higher magnification than that used in standard photography, reveal additional details of epithelial changes. The presented morphology will facilitate understanding of clinical appearances and assist in differential diagnosis.
  • 2007 Springer
    Volker Schumpelick, Robert J. Fitzgibbons (eds.).
  • 2016 Springer
    Asher Bashiri, Avi Harlev, Ashok Agarwal, editors.
    Part I: Introduction to Recurrent Pregnancy Loss -- Recurrent pregnancy loss: definitions, epidemiology, and prognosis -- Implantation, Physiology of Placentation -- Part II: Causes of Recurrent Pregnancy Loss -- Endocrine abnormalities in RPL -- Genetics of recurrent pregnancy loss -- Inherited and Acquired Thrombophilias and Adverse Pregnancy Outcomes -- Immunological causes of recurrent pregnancy loss -- Anatomical aspects in recurrent pregnancy loss -- Male Factors in Recurrent Pregnancy Loss -- Lifestyle and RPL -- The common characteristics between Infertility and recurrent pregnancy loss -- Part III: Management of Recurrent Pregnancy Loss. Contemporary Prevention and treatment of recurrent pregnancy loss -- Part IV: Psychological and Supporting Aspects of Recurrent Pregnancy Loss -- The healthcare giver's perspective -- The importance of emotional support for women with recurrent RPL -- A Patient's Perspective -- Part V: The Future -- New Frontiers in RPL research and treatment.
  • 2012 CRCnetBASE
    Oguz K. Baskurt, Bjorn Neu, Herbert J. Meiselman.
    Ch. 1. Introduction -- ch. 2. Determinants of red blood cell aggregation -- ch. 3. Mechanism of red blood cell aggregation -- ch. 4. Measurement of red blood cell aggregation -- ch. 5. Effect of red blood cell aggregation on in Vitro blood rheology -- ch. 6. Effect of red blood cell aggregation on tube flow -- ch. 7. In Vivo hemodynamics and red blood cell aggregation -- ch. 8. Alterations in red blood cell aggregation -- ch. 9. Comparative aspects of red blood cell aggregation.
  • Silverchair
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Also available: Print – 1970-<2012>
  • 2011
    Scott Carney.
    Status: Not Checked OutLane Catalog Record
    A shocking tour through a macabre global underworld where organs, bones, and live people are bought and sold on the red market. Investigative journalist Scott Carney has spent five years tracing the lucrative and deeply secretive trade in human bodies and body parts. The Red Market reveals the rise, fall, and resurgence of this multibillion-dollar underground trade through history, from early medical study and modern universities to poverty-ravaged Eurasian villages and high-tech Western labs; from body snatchers and surrogate mothers to skeleton dealers and the poor who sell body parts to survive. While local and international law enforcement have cracked down on the market, advances in science have increased the demand for human tissue--ligaments, kidneys, even rented space in women's wombs--leaving little room to consider the ethical dilemmas inherent in the flesh-and-blood trade--From publisher description.
  • 2011
    Kimberly Allison.
    "Dr. Kimberly Allison diagnoses breast cancer for a living. But as a 33-year-old healthy new mother, she never expected to find herself looking at her own malignant cells under the microscope. Like many others diagnosed with cancer, Dr. Allison was starving for stories of other survivors. She wanted to hear someone's tale, to feel their experiences and look for hidden clues to what her own future might hold. Ultimately, the story that Dr. Allison was looking for was found in her own life. Red Sunshine is a memoir about Dr. Allison's sudden journey from physician to patient and her attempt to make the most of this terrifying and unexpected ordeal. Her experience reflects the incredible power of the bonds of friendship and family. It is about paying attention to the magic that is waiting to be uncovered in everyday life. Red Sunshine is an uplifting story of survival in which Dr. Allison shares all the intimate details of her emotional journey with both humor and honesty"-- Provided by publisher.
  • 2013
    by Heidi M. Feldman.
    Status: Not Checked OutLane Catalog Record
    What are disabilities? -- Why focus on children with disabilities? -- What are the challenges in delivering health care to children with disabilities? -- Inclusion -- Contribution -- Health -- Focusing health care on function -- Comprehensive integrated care plans -- Family- and person-centered care -- Care coordination / with Alexis Hansen -- Changing professional education -- Research / with Nathan J. Blum -- Public policy.
  • 2012 Springer
    Venkat R. Machiraju, Hartzell V. Schaff, Lars G. Svensson, editors.
  • 2014 ScienceDirect
    edited by Danyelle M. Townsend, Kenneth D. Tew.
    Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz -- Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki -- Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan -- Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend -- A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper -- Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik -- Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang -- Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.
  • pt. A-B, 2002. ScienceDirect
    pt. B ScienceDirect
    edited by Chandan K. Sen, Lester Packer ; editorial advisory board, John F. Engelhardt ... [et al.].
    Also available: Print – pt. A-B, 2002.
  • 2006
    edited by Isabella Dalle-Donne, Andrea Scaloni, and D. Allan Butterfield.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by Judith P. Klinman.
    Also available: Print – 1995
  • 2008 Springer Protocols
    edited by John T. Hancock.
    The role of redox in signal transduction / John T. Hancock -- The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence / Andrew G. Pinder ... [et al.] -- Detection and measurement of reactive oxygen intermediates in mitocondria and cells / Matthew Whiteman ... [et al.] -- Redox-sensitive green fluorescent protein : probes for dynamic intracellular redox responses : a review / Mark B. Cannon and S. James Remington -- Measuring redox changes in vivo in leaves : prospects and technical challenges / Philip M. Mullineaux and Tracy Lawson -- Imaging of intracellular hydrogen peroxide production with hyper upon stimulation of hela cells with Egf / Kseniya N. Markvicheva ... [et al.] -- Tools to investigate ROS sensitive signalling proteins / Radhika Desikan ... [et al.] -- Methods for preparing crystals of reversibly oxidized proteins : crystallization of protein tyrosine phophatase 1b as an example / Annette Salmeen and David Barford -- Methods for the study of redox-mediated changes in p53 structure and function / Kristine Mann -- Redox regulation and trapping sulphenic acid in the peroxide sensitive human mitochondrial branched chain aminotransferase / Susan M. Hutson ... [et al.] -- Detection of carbonylated proteins in 2-D SDS page separations / Rukhsana Sultana ... [et al.] -- Analysis of global and specific changes in the disulfide proteome using redox 2D-PAGE / Robert C. Cumming -- Protein-thiol oxidation from single proteins to proteome-wide analyses / Natacha Le Moan, Frédérique Tacnet, and Michel B. Toledano -- Analysis of redox relationships in the plant cell cycle : determinations of ascorbate, glutathione, and poly (ADPribose) polymerase (PARP) in plant cell cultures / Christine H. Foyer ... [et al.] -- Generation and detection of S-nitrosothiols / Christian Lindermayr, Simone Sell, and Jörg Durner.
  • 2014 Springer
    Toshiyuki Mori, Giovanni Dapri, editors.
    Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments. Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.
  • Suzanne H. Reuben for the The President's Cancer Panel.
  • 2015 Springer
    Giovanni Landoni, Marta Mucchetti, Alberto Zangrillo, Rinaldo Bellomo, editors.
  • 2014 Springer
    Giovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.
    This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists.
  • 2011 Springer
    Arden Handler, Joan Kennelly, Nadine Peacock, editors.
    Introduction: challenges in reducing disparities in reproductive and perinatal outcomes through evidence-based public health -- Methodological approach to assessing the evidence -- Evidence-based public health: origins, assumptions, and cautions -- Access to family planning and induced abortion -- Preconceptional health promotion -- Infertility status and infertility treatment: racial and ethnic disparities -- Public health interventions for perinatal HIV and STI screening in pregnancy -- What is the role of prenatal care in reducing racial and ethnic disparities in pregnancy outcomes? -- Current approaches to reducing premature births and implications for disparity elimination -- Prenatal case management of pregnant women: what is the evidence for its contribution to a reduction of disparities in perinatal outcomes? -- Behavioral treatment methods for pregnant smokers: the evidence base for prenatal care programs and professional practice -- Substance abuse in pregnancy: the impact of screening and treatment on improving perinatal outcomes and reducing racial and ethnic disparities -- The evidence for perinatal depression screening and treatment -- Supplemental nutrition programs during pregnancy and the early postnatal period -- Group prenatal care and doula care for pregnant women -- Contemporary childbirth in the United States: interventions and disparities -- Regionalized perinatal care: an evidence-based intervention in development.
  • 2013 R Soc Chem
    edited by David G. Allen and Michael D. Waters.
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • 2015 Springer
    Raj Mathur, editor.
    1. The Challenges of Multiple Pregnancies -- 2. Prognosis of Risks for Offspring of Fertility Treatment -- 3. Ovarian Hyperstimulation Syndrome -- 4. Thromboembolism Associated with Fertility Treatment -- 5. Emotional and Psychosocial Risk Associated with Fertility Treatment -- 6. Regulatory and Legal Risks for Patients.
  • 2012 ClinicalKey
    volume editors, Matthew T. Ranson, Jason E. Pope.
    Complications of Spinal Cord Stimulation -- Complications of Peripheral Nerve Stimulation : Open Technique, Percutaneous Technique, and Peripheral Nerve Field Stimulation -- Complications of Cranial Nerve Stimulation -- Avoidance, Recognition, and Treatment of Complications in Cranial Neuromodulation for Pain -- Complications of Intrathecal Drug Delivery Systems -- Complications of Therapeutic Minimally Invasive Intradiscal Procedures -- Complications Related to Radiofrequency Procedures for the Treatment of Chronic Pain -- Complications of Lumbar Spine Fusion Surgery -- Complications of Nucleus Replacement and Motion-Sparing Technologies -- Complications of Spinal Injections and Surgery for Disc Herniation -- Radiation Safety and Complications of Fluoroscopy, Ultrasonography, and Computed Tomography -- Complications Associated with Head and Neck Blocks, Upper Extremity Blocks, Lower Extremity Blocks, and Differential Diagnostic Blocks -- Complications of Epidural Injections -- Complications of Facet Joint Injections and Medial Branch Blocks -- Complications of Radiofrequency Rhizotomy for Facet Syndrome -- Complications of Sacroiliac Joint Injection and Lateral Branch Blocks, Including Water-Cooled Rhizotomy -- Complications of Percutaneous Vertebral Augmentation : Vertebroplasty and Kyphoplasty -- Complications of Intraarticular Joint Injections and Musculoskeletal Injections.
  • 2007 CRCnetBASE
    edited by David Kilcast and Fiona Angus.
    pt. 1. Dietary salt, health and the consumer -- pt. 2. Strategies for salt reduction in food products -- pt. 3. Reducing salt in particular foods.
  • 2015
    Jeffrey Levi, Laura M. Segal, Anne De Blasi, Alejandra Martin.
    In this report, the Trust for America's Health (TFAH) examines how to help move towards a strong prevention-oriented, continuum-of-care approach to substance misuse -- looking at policies and programs that have a high impact for improving the well-being of America's youth. Section 1 reviews 10 examples of important policy indicators or programs that states may have in place that can have an impact on the well-being of children and youth and/or have been connected with preventing and reducing youth substance misuse. The indicators reflect a range of types of policies that support a prevention-intervention-treatment approach -- from supporting healthier schools and communities to limiting access to substances to providing positive support and treatment. Section 2 featuers recommendations for modernizing the nation's strategy for addressing youth substance misuse by imprementing a research-based public health approach.
  • NLM
    Also available: Print – 1989
  • 2008 Springer
    edited by S.H. Fatemi.
  • 2005 Springer
    edited by K.R.H. von Wild in cooperation with G.A. Brunelli.
    Also available: Print – 2005
  • 2006
    Kay Ann Cassell and Uma Hiremath.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    edited by Rainer Hofmann-Wellenhof, Giovanni Pellacani, Joseph Malvehy, Hans Peter Soyer.
    Part 1. Confocal Reflectance Microscopy - the Essentials -- The Confocal Story -- How Reflectance Confocal Microscopy Works -- A Hands-on Guide to Confocal Imaging -- Part 2. Normal Skin -- Epidermis, Dermis and Epidermal Appendages -- Acral Volar Skin, Facial Skin and Mucous Membrane -- Part 3. Melanocytic lesions -- Semeiology and Pattern Analysis in Melanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Part 4. Melanocytic lesions: Nevi -- Common Nevi -- Atypical/Dysplastic Nevi -- Spitz Nevi -- In Vivo Confocal Reflectance Microscopy of Congenital Melanocytic Nevi -- The Many Faces of Nevi: Blue, "Black" and Recurrent Nevi -- Part 5. Melanocytic lesions: Melanoma -- Superficial Spreading Melanoma -- Melanoma Progression -- Nodular Melanoma -- Lentigo Maligna -- Amelanotic Melanoma -- Part 6. Non-melanocytic Skin Lesions -- Semiology and Pattern Analysis in Nonmelanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Solar Lentigo, Seborrheic Keratosis and Lichen Planus-Like Keratosis -- Basal Cell Carcinoma -- Actinic Keratosis -- Squamous Cell Carcinoma -- Cutaneous Lymphoma -- Potpourri of Nonmelanocytic Skin Lesions -- Part 7. Inflammatory Skin Diseases -- The Semiology and Patterns of Inflammatory Skin Conditions -- Hyperkeratotic Dermatitis -- Spongiotic Dermatitis -- Interface Dermatitis -- Pigmentary Skin Disorders -- Part 8. Monitoring of Skin Lesions and Therapy Control -- Follow-up of Nevi -- Monitoring of Nonsurgical Treatment of Skin Tumors -- Confocal Mosaicing Microscopy in Skin Excisions: Feasibility of Cancer Margin Screening at the Bedside to Guide Mohs Surgery -- Reflectance Confocal Microscopy Applications in Cosmetology -- Part 9. Future Aspects -- Tele-Reflectance Confocal Microscopy -- Automated Diagnosis and Reflectance Confocal Microscopy -- Experimental Applications and Future Directions -- Part 10. Glossary -- Reflectance Confocal Microscopy Imaging: A Glossary of Terminology.
  • 2002 HighWire
    edited by S. Kaul and A. Lahiri.
    Also available: Print – 2002
  • 2005 Springer
    editors, I. Howard Fine, Mark Packer, Richard S. Hoffman.
    Ch. 1 Crystalline lens as a target for refractive surgery -- Ch. 2 Refractive lens exchange as a refractive surgery modality -- Ch. 3 Biometry for refractive lens surgery -- Ch. 4 Intraocular lens power calculations: correction of defocus -- Ch. 5 IOL calculations following keratorefractive surgery -- Ch. 6 Correction of keratometric astigmatism: incisional surgery -- Ch. 7 STAAR toric IOL -- Ch. 8 Correction of keratometric astigmatism: AcrySof toric IOL -- Ch. 9 Wavefront technology of spherical aberration -- Ch. 10 The Eyeonics Crystalens -- Ch. 11 Presbyopia - cataract surgery with implantation of the accommodative posterior chamber lens ICU -- Ch. 12 Synchrony IOL -- Ch. 13 Sarfarazi elliptical accommodative intraocular lens -- Ch. 14 AcrySof ReStor pseudo-accommodative IOL -- Ch. 15 The Tecnis Multifocal IOL -- 16 Blue-light-filtering intraocular lenses -- Ch. 17 The light-adjustable lens -- Ch. 18 Injectable polymer -- Ch. 19 The vision membrane -- Ch. 20 Bimanual ultrasound phacoemulsification -- Ch. 21 Low ultrasound microincision cataract surgery -- Ch. 22 The Infiniti Vision System -- Ch. 23 The Millenium -- Ch. 24 The Staar Sonic Wave -- Ch. 25 AMO Sovereign with WhiteStar Technology -- Ch. 26 Refractive lens exchange in high myopia: weighing the risks -- Ch. 27 Conclusion: the future of refractive lens surgery -- Subject index. DVD: 1. Transition to bimanual phaco -- 2. Bimanual vertical chop technique #1 -- 3. Bimanual vertical chop technique #2 -- 4. VST torn capsule -- 5. Bimanual post PKP post RK -- 6. Spinoffs of bimanual technology.
    Also available: Print – 2005
  • 2008 ClinicalKey
    edited by F. Hampton Roy.
    1. Bausch & Lomb 217z100 excimer laser platform / Sheraz M. Daya and Marcela Espinosa-Lagana -- 2. Custom LASIK and PRK with the Visx Star Laser / Michael J. Taravella, Richard S. Davidson and Scott A. Thomas -- 3. The LadarVision system / Ronald R. Krueger -- 4. WaveLight Allegretto / Simon Holland and C. David Lin -- 5. Nidek Navex / Mihai Pop and Harkaran S. Bains -- Schwind ESIRIS excimer laser / Diego de Ortueta, Thomas Magnago and Jens Flügge -- 7. Optimized and wavefront-guided corneal refractive surgery using the Carl Zeiss Meditec platform: CRS-Master and MEL 80 excimer laser / Daniel Z. Reinstein et al. -- 8. Multifocal cornea / Gustavo E. Tamayo -- 9. Katana LaserSoft: a solid-state laser for refractive surgery / Matteo Piovella, Fabrizio I. Camesasca and Barbara Kusa -- 10. CustomVis Pulzar Z1 / Tarak Pujara -- 11. Refractive lens exchange / Mark Packer, I. Howard Fine, Richard S. Hoffman and H. Burkhard Dick -- 12. Surgical reversal of presbyopia / Gene W. Zdenek and Jack C. Griffis.
  • 2014 Springer
    Aniyizhai Annamalai, editor.
    "Physicians receive very little training in refugee health. Refugee Health Care is a practical guide providing concise information for busy practitioners. This concise textbook reviews common conditions seen in refugees and some of the recommendations in the book apply to all immigrants. It will be a valuable resource for primary care physicians, psychiatrists, pediatricians, women's health providers and any health care practitioner who treats refugees."--Publisher's website.
  • 2011 Springer
    Ira S. Cohen, Glenn R. Gaudette, editors.
    Inducing embryonic stem cells to become cardiomyocytes / Alexander M. Becker, Michael Rubart, and Loren J. Field -- Regenerating function in vivo with myocytes derived from embryonic stem cells / Priya R. Baraniak and Todd C. McDevitt -- Excitation-contraction coupling, functional properties, and autonomic and hormonal regulation in human embryonic stem cell derived cardiomyocytes / Oshra Sedan and Ofer Binah -- Embryonic stem cell derivatives for cardiac therapy : advantages, limitations, and long-term prospects / Michal Weiler-Sagie and Lior Gepstein -- Methods for differentiation of bone-marrow-derived stem cells into myocytes / Shinji Makino and Keiichi Fukuda -- Homing, survival, and paracrine effects of human mesenchymal stem cells / Sergey Doronin -- Bone marrow cell therapy after myocardial infarction : what have we learned from the clinical trials and where are we going? / Kai C. Wollert -- Evidence for the existence of resident cardiac stem cells / Isotta Chimenti ... [et al.] -- Multiple sources for cardiac stem cells and their cardiogenic potential / Antonio Paolo Beltrami, Daniela Cesselli, and Carlo Alberto Beltrami -- Skeletal muscle stem cells in the spotlight : the satellite cell / Zipora Yablonka-Reuveni and Kenneth Day -- Regenerating mechanical function in vivo with skeletal myoblasts / Todd K. Rosengart and Muath Bishawi -- Methods for inducing pluripotency / Raymond L. Page, Christopher Malcuit, and Tanja Dominko -- Inducible pluripotent stem cells for cardiac regeneration / Naama Zeevi-Levin and Joseph Itskovitz-Eldor -- Induced pluripotent cells for myocardial infarction repair / Timothy J. Nelson and Andre Terzic -- Substrates of cardiac reentrant arrhythmias : the possible role of tissue regeneration and replacement / André G. Kléber -- Integration of stem cells into the cardiac syncytium : formation of gap junctions / Peter R. Brink, Ira S. Cohen, and Richard T. Mathias -- Bradyarrhythmia therapies : the creation of biological pacemakers and restoring atrioventricular node function / Richard B. Robinson -- Tachyarrhythmia therapies : approaches to atrial fibrillation and postinfarction ventricular arrhythmias / J. Kevin Donahue and Kenneth R. Laurita -- Long-term prospects for arrhythmia treatment : advantages and limitations of gene and cell therapies / Michael R. Rosen -- Regenerating blood vessels / Tracy A. Gwyther and Marsha W. Rolle -- Regenerating heart valves / Benedikt Weber and Simon P. Hoerstrup -- Tissue engineering strategies for cardiac regeneration / Amandine F.G. Godier-Furnémont ... [et al.] -- Methods of cell delivery for cardiac repair / Sarah Fernandes and Hans Reinecke -- Tracking of stem cells in vivo / Yingli Fu and Dara L. Kraitchman -- Assessing regional mechanical function after stem cell delivery / Jacques P. Guyette and Glenn R. Gaudette.
  • 2005 Springer
    A. Keating ... [et al.], editors.
  • 2012 ScienceDirect
    David L. Stocum.
  • 2006 ScienceDirect
    David L. Stocum.
  • 2012 Springer
    edited by Rahul Jandial, Mike Y. Chen ; associate editors, Bihong T. Chen, Joseph Ciacci.
    Frontiers of spinal cord and spine repair : experimental approaches for repair of spinal cord injury / Choya Yoon and Mark H. Tuszynski -- Stem cell based strategies for spinal cord injury repair / Alexa Reeves and Hans S. Keirstead -- Strategies for endogenous spinal cord repair : HPMA hydrogel to recruit migrating endogenous stem cells / Araceli Espinosa-Jeffrey ... [et al.] -- Stem cells and spinal cord injury repair / Soheila Karimi-Abdolrezaee and Eftekhar Eftekharpour -- Chronic pain following spinal cord injury / Radi Masri and Asaf Keller -- Repair of radiation damage and radiation injury to the spinal cord / Timothy E. Schultheiss -- Malignancies of the spinal cord / J. Dawn Waters, Encarnacion Maria Navarro Peran, and Joseph Ciacci -- Molecular basis of intervertebral disc degeneration / Dipika Gopal ... [et al.] -- Bioceramics for osteogenesis, molecular and cellular advances / Hande Demirkiran -- Cell-based therapies for spinal fusion / Ronke Olabisi -- Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering / Josh Neman ... [et al.] -- Progenitor cells : role and usage in bone tissue engineering approaches for spinal fusion / Lonnissa H. Nguyen ... [et al.].
    Also available: Print – 2012
  • 2011 Springer
    Gustav Steinhoff, editor.
  • 2015 Springer
    Niranjan Bhattacharya, Phillip George Stubblefield, editors.
    This book represents a major contribution to the emerging science of regenerative medicine using non-fetal sources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have brought together some of the most pre-eminent scientists working on regenerative medicine to share information on currently ongoing work in this area alongside unpublished observations that will help to shape the contours of future therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem Cells discusses the potential clinical and therapeutic applications using non-fetal stem cells as well as providing instruction on the collection, isolation and characterization of stem cells from various non-fetal sources, such as menstrual blood, adipose tissue, breast milk and uprooted decidual teeth. This book will be an invaluable resource for both active researchers and those entering the field. The Editors truly hope that the text will act as a stimulant to professionals and clinical scientists, who may be inspired to further the work of the pioneering scientists who have contributed to this volume.
  • 2013 Springer
    Hossein Baharvand, Nasser Aghdami, editors.
    1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
  • 2014 ScienceDirect
    [edited by] Giuseppe Orlando, Jan Lerut, Shay Soker, Robert J. Stratta.
    Principles of regenerative medicine and cell,tissue and organ bioengineering -- Kidney -- Liver -- Heart -- Small bowel -- Endocrine pancreas and islets of langerhans -- Lung -- Composite tissues allotranplantation -- Immunosuppression-free transplantation in the regenerative medicine era.
  • 2014 Springer
    Linda F. Hogle, editor.
    Regenerative medicine is at a pivotal point. Innovations in the science and the rapid growth of translational medicine are transforming the field just as institutional arrangements are changing, making this an exciting yet unsettled time. Recent court cases and policy initiatives are creating crosscurrents that keep older issues from being settled while introducing new dilemmas. Current research propels collaborations across disciplines and sectors, raising the question of how tensions between the protection of intellectual property and the movement toward "open science" can be negotiated. Other important social, ethical and legal questions arise in the gray areas created by new scientific techniques and pragmatic areas involved in scale-up and testing in humans. The times call for governance that is adaptive to meet the needs of science yet able to maintain public trust. The contributors address these and other vital questions through chapters focusing on topics such as data sharing; patenting of human biological material; and managing collaborations across academic, industry and government sectors as well as across national boundaries. Key research ethics issues are also included such as obtaining consent from biospecimen donors; accessing biorepository data, and considerations in designing preclinical and clinical trial protocols for first-in-human research, including upcoming policy changes. Rather than retracing well-trodden topics, the book points to nascent areas that need to be addressed. Whether working in academia, industry, or government, regenerative medicine scientists and managers need to know how to navigate current and upcoming issues of governance facing the field. Regenerative Medicine Ethics: Governing Research and Knowledge. Practices will be a valuable resource for scientists, policy-makers and students as they plan and execute responsible research.
  • 2014 Springer
    Juichi Ito, editor.
    The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
  • 2015 Springer
    Juichi Ito, editor.
    Preface -- Part 1: Current siguation of the regenerative medicine -- Chapter 1: Current siguation of the regenerative medicine -- Part 2: Development and regeneration of the ear.- Chapter 2: The innner ear -- Chapter 3: Regeneration of the Soft Tissue Defects of the External Auditory Meatus -- Chapter 4: Regeneration of the Tympanic Membrane -- Chapter 5: An approach in regenerative medicine for the treatment of intractable otitis media -- Chapter 6: Peripheral Nerve Regeneration by Tissue Engineering for Prevention of Misdirection -- Part 3: Development and regeneration of the nose and the paranasal sinuses -- Chapter 7: Development and regeneration of the nose and the paranasal sinuses -- Part 4: Development and regeneration of the oral cavity and the pharynx -- Chapter 8: Development and regeneration of the oral cavity and the pharynx -- Part 5: Development and regeneration of the larynx -- Chapter 9: Laryngeal Development -- Chapter 10: Laryngeal framework regeneration -- Chapter 11: Vocal folds Development -- Chapter 12: Regeneration of the vocal fold -- Part 6: Development and regeneration of the head & neck -- Chapter 13: Cranial bone regeneration -- Chapter 14: Salivary gland development and regeneration -- Chapter 15: Regeneration of the Trachea -- Chapter16: Future perspective.
  • 2011 Springer
    Niranjan Bhattacharya, Phillip Stubblefield (editors).
    A massive wastage of the global resources -- Placenta as a source of stem cells and as a key organ for fetomaternal tolerance -- Placenta and umbilical cord in traditional Chinese medicine -- Use of umbilical venous blood on assessing the biochemical variations of acid-base, nutritional and metabolic parameters on growth-retarded fetuses, in comparison with gestational control cases: a study -- Umbilical cord blood transfusion and its therapeutic potentialities -- Autologous placental blood transfusion for the therapy of anemic neonates -- Cord blood: a massive waste of a life-saving resource: a perspective on its current and potential uses -- Clinical experience of cord blood autologous transfusion -- Emergency use of human cord blood -- Hemoglobin-based oxygen carriers in trauma care: the US multicenter prehospital trial -- Placental umbilical cord blood as a true blood substitute with an edge -- Implications of feto-maternal cell transfer in normal pregnancy -- Early reports on the prognostic implications and immunotherapeutic potentials of Cd34 rich cord whole blood transfusion in advanced breast cancer with severe anemia -- Anti-inflammatory effects of human cord blood and its potential implications in neurological disorders -- Transforming "waste" into gold: identification of novel stem cells resources with therapeutic potential in neuromuscular disorders -- Human umbilical cord blood cells for stroke -- Placental umbilical cord blood transfusion for stem cell therapy in neurological diseases -- Umbilical cord and its blood: a perspective on its current and potential use in ophthalmology -- Umbilical vein grafts for lower limb revascularization -- Cord blood stem cells in angiogenesis. Endothelial progenitor cells from cord blood: magic bullets against ischemia? -- Therapeutic potential of placental umbilical cord blood in cardiology -- Stem cell therapy for heart failure using cord blood -- Human umbilical cord blood mononuclear cells in the treatment of acute myocardial infarction -- Umbilical cord-derived mesenchymal stem cells -- Cord blood stem cell expansion ex vivo: current status and future strategies -- Embryonic-like stem cells and the importance of human umbilical cord blood for regenerative medicine -- Use of non-hematopoietic stem cells of fetal origin from cord blood, umbilical cord, and placenta in regeneration medicine -- Animal studies of cord blood and regeneration -- Immune privilege of cord blood -- Combination cellular therapy for regenerative medicine: the stem cell niche -- Use of cord blood in regenerative medicine -- Comparisons between related and unrelated cord blood collection and/or banking for transplantation or research: the UK NHS blood and transplant experience -- Donor and collection-related variables affecting product quality in ex utero cord blood banking -- Cord blood as a source of hematopoietic progenitors for transplantation -- Amniotic fluid and placenta stem cells -- Use of amniotic membrane, amniotic fluid, and placental dressing in advanced burn patients -- Clinical use of amniotic fluid in osteoarthritis: a source of cell therapy -- A study and follow-up (1999-2009) of human fetal neuronal tissue transplants at a heterotopic site outside the brain in cases of advanced idiopathic Parkinsonism -- Ethical issues surrounding umbilical cord blood donation and banking.
  • 2011 ScienceDirect
    2011 ClinicalKey
    edited by Michael S. Goligorsky.
    Chapter 1. Glomerulogenesis and De Novo Nephrogenesis in Medaka Fish: An Evolutionary Approach / Hisashi Hashimoto, Yuko Wakamatsu -- Chapter 2. Renal Organogenesis: Growing a Replacement Kidney In Situ from Transplanted Renal Primordia / Marc R. Hammerman -- Chapter 3. Use of Genetic Mouse Models to Study Kidney Regeneration / Akio Kobayashi, Jeremy S. Duffield -- Chapter 4. Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease / Charles N. Serhan, Catherine Godson -- Chapter 5. Tissue Protection and Regeneration Aided by Erythropoietin and Erythropoietin-derived Peptides / Danilo Fliser -- Chapter 6. Mast Cells in Kidney Regeneration / Eric Daugas, Walid Beghdadi, Ulrich Blank -- Chapter 7. Role of Macrophages in Renal Injury, Repair and Regeneration / Vincent Lee, Qi Cao, Yiping Wang, David C.H. Harris -- Chapter 8. T-cell Contribution to Injury and Regenerative Processes in Kidney Diseases: Focus on Regulatory T Cells / Hye Ryoun Jang, Hamid Rabb -- Chapter 9. Mesenchymal Stem Cells / Benjamin D. Humphreys, Joseph V. Bonventre -- Chapter 10. Endothelial Progenitor Cells and the Kidney / Matthieu Monge, Anton Jan van Zonneveld, Ton J. Rabelink -- Chapter 11. Potential of the Side Population in Regenerative Nephrology / M.H. Little, G.A. Challen -- Chapter 12. Very Small Embryonic-like Stem Cells and Their Potential Relevance for Kidney Homeostasis / Dong-Myung Shin, Rui Liu, Przemyslaw Nowacki, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak -- Chapter 13. Induced Pluripotent Stem Cells / Kenji Osafune, Shinya Yamanaka -- Chapter 14. Methods of Isolation and Culture of Adult Stem Cells / Lindolfo da Silva Meirelles, Nance Beyer Nardi -- Chapter 15. Stem Cell Niche in the Kidney / Laura Lasagni, Elena Lazzeri, Paola Romagnani -- Chapter 16. Bioartificial Stem Cell Niches: Engineering a Regenerative Microenvironment / Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff, Michael S. Goligorsky -- Chapter 17. Imaging of Transplanted and Native Stem Cells / Xiang-Yang Zhu, Martin Rodriguez-Porcel, Lilach O. Lerman -- Chapter 18. Stem Cell Injury and Premature Senescence / Michael S. Goligorsky -- Chapter 19. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway / Nica M. Borradaile, Alanna Watson, J. Geoffrey Pickering -- Chapter 20. Bone Marrow Mesenchymal Stem Cells in Organ Repair and Strategies to Optimize their Efficacy / Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi, Marina Morigi -- Chapter 21. Treatment of Acute Kidney Injury with Allogeneic Mesenchymal Stem Cells: Preclinical and Initial Clinical Data / Florian E. Tögel, Christof Westenfelder -- Chapter 22. Clinical Trials in Renal Regenerative Medicine / Maarten B. Rookmaaker, Jaap A. Joles, Marianne C. Verhaar -- Chapter 23. Potential Risks of Stem Cell Therapies / Uta Kunter, Jürgen Floege -- Chapter 24. Tissue Engineering in Urology / Anthony Atala -- Chapter 25. Ethics in Regenerative Medicine / Svetlana Gavrilov, Donald W. Landry -- Chapter 26. Stem Cell Banking / Vicente Mirabet, Pilar Solves.
  • 2013 Cambridge
    edited by George J. Christ, Karl-Erik Andersson.
    "Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research"--Provided by publisher.
  • 2012 Springer
    David S. Allan, Dirk Strunk, editors.
  • 2012
    George Church & Ed Regis.
    Status: Not Checked OutLane Catalog Record
    From bioplastics to H. sapiens 2.0 -- -3,800 Myr, Late Hadean : at the inorganic/organic interface -- -3,500 Myr, Archean : reading the most ancient texts and the future of living software -- -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be? -- -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum" -- -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering -- -30,000 Yr, Pleistocene Park : engineering extinct genomes -- -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto -- -100 Yr, Anthropocene : the third industrial revolution ; iGEM -- -1 Yr, Holocene : from personal genomes to immortal human components -- Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
  • edited by Paul Kopperman.
    In 1746, Dr. John Buchanan, a recently retired medical officer in the British Army, produced a manuscript, 'Regimental Practice, or a Short History of Diseases common to His Majesties own Royal Regiment of Horse Guards when abroad (Commonly called the Blews).' Revised almost until the time of Buchananan's death in 1767, it was primarily based on the author's observations while surgeon to a cavalry regiment serving in Flanders 1742-1745 during the War of the Austrian Succession. It is presented here as an annotated modern edition of the text.
  • v. 2, 1945-.
    by Charles V. Morrill ...
    Status: Not Checked OutLane Catalog Record
    [v. 1] The upper extremity -- [v. 2] The neck and head -- [v. 3] The abdomen and pelvis -- [v. 4] The thorax and back.
  • v. 1-2, 1955-59.
    Taylor, John Alexander.
    Status: Not Checked OutLane Catalog Record
    pt. 1. Head and neck -- pt. 2. Thoracic limb -- pt. 3. Pelvic limb -- pt. 4. Thorax and abdomen.
  • 2009 ClinicalKey
    Dell R. Burkey.
    "Never before has essential guidance been so quick and convenient to access on the go! "Regional Anesthesia and Pain Management: Handbook and iPod" truly puts the answers you need at your fingertips. Under the superb leadership of Series Editor Lee A. Fleisher, MD, experts from the University of Pennsylvania present practical coverage of regional anesthesia and pain management in a concise, at-a-glance manner. A consistent, bulleted format and concise images make it remarkably easy to review and learn even the most difficult procedures and quickly resolve thorny clinical questions. Whether you consult the pocket-sized handbook, or download the content onto your standard click-wheel iPod, you'll be amazed how easy it is to look up vital information quickly."--Publisher's website.
  • 2012 Cambridge
    Jeff Gadsden.
    1. Principles of pain management in trauma care -- 2. Acute pain, regional anesthesia and the stress response -- 3. The progression from acute to chronic pain -- 4. Prehospital regional anesthesia -- 5. Regional anesthesia and digital replantation -- 6. Regional anesthesia and compartment syndrome -- 7. Regional anesthesia for blunt chest trauma -- 8. Regional anesthesia, trauma, and complex regional pain syndrome -- 9. Regional anesthesia and combat care -- 10. Regional anesthesia for pediatric trauma -- 11. Regional anesthesia for fractured neck of femur -- 12. Regional anesthesia in the intoxicated trauma patient -- 13. Regional anesthesia for humeral shaft fracture -- 14. Regional anesthesia for burns -- 15. Regional anesthesia, penetrating abdominal trauma and sepsis -- 16. Regional anesthesia in the injured obese patient -- 17. Regional anesthesia and lower extremity trauma -- 18. Regional anesthesia and traumatic limb amputation -- 19. Complications of brachial plexus blockade -- 20. Regional anesthesia and trauma in pregnancy -- 21. Regional anesthesia and the injured athlete.
  • 2007 Springer
    edited by Peter M. Schlag, Ulrike Stein ; foreword by Alexander M.M. Eggermont.
  • 2015 Springer
    Danilo Jankovic, Philip Peng.
    General Considerations -- Head and Neck Region -- Cervical Region -- Shoulder -- Upper extremity -- Elbow and Wrist -- Thoracic Region -- Lumbosacral spine -- Abdominal and Pelvic region -- Lower extremity block -- Lower extremity musculoskeletal injection -- Regional block for children.
  • 2011
    David Yoonsuk Oh.
    T cell development involves stereotyped movements of developing thymocytes through specific stromal microenvironments in thymus, with immature double-negative (DN, CD4-CD8-) and double-positive (DP, CD4+CD8+) thymocytes found in cortex, and mature single-positive (SP, CD4+CD8- or CD4-CD8+) thymocytes in medulla. Critical events occur in each of these locations, notably positive selection, which leads to survival and maturation of DPs and occurs in cortex, and negative selection, which leads to elimination of autoreactive thymocytes and can occur in cortex or medulla depending on the type of antigen. Several key questions remain about the mechanisms underlying these developmental transitions. How are thymocytes properly localized to cortex and medulla? Is there further specialization of stroma within these regions for supporting thymocyte migration or signaling? How do Ca2+ signals, which are critical for both positive and negative selection, differ between these two developmental pathways? In this thesis, we utilize thymic slices, which preserve native stromal architecture and support thymocyte development, to address these questions. Two-photon microscopy of fluorescently labeled thymocytes within slices allows us to non-invasively image the migration, localization, and signaling of single thymocytes in real time, providing a better understanding of how these behaviors are regulated during development and also as a function of location in tissue. In Chapter 2, we address the question of how developing thymocytes are localized to their proper tissue locations in thymus. When layered on the cut surface of slices, purified stages of thymocytes localize to their proper thymic environments, with immature DNs and DPs restricted to cortex, and SPs concentrating in medulla. Remarkably, we find evidence for two distinct mechanisms controlling proper localization of immature versus mature thymocytes. Pre-selection DPs are strictly localized to cortex by their inability to migrate on medullary substrates. SPs localize to medulla via CCR7-dependent chemotaxis, which is directly demonstrated, as well as a novel GPCR-mediated signaling module permitting SP migration on medullary substrates. In Chapter 3, we examine differences in Ca2+ signaling between positive versus negative selection, as well as between distinct locations in thymus, and clarify the role of Ca2+ in controlling motility during negative selection. We find larger Ca2+ signals during early stages of negative selection relative to positive selection, and stronger signaling in response to selecting antigens in the inner cortex near medulla. Sustained Ca2+ signals during negative selection are largely not required for stopping cells, but do contribute to prolonging motile arrest of a proportion of the thymocyte population. Overall these results point to several key events during the transition from cortical DPs to medullary SPs that may enhance the efficiency of selection. As DPs pass through a specialized inner cortical environment, they may become more responsive to peptide ligands leading to positive and negative selection. Stronger Ca2+ signals during negative compared to positive selection in DPs and SPs may help to commit thymocytes to death over maturation. Finally, the ability to migrate in medulla, which thymocytes acquire post-positive selection, may represent an important developmental switch confining pre-selection cells to cortex for further testing against selecting antigens, while permitting post-positive selection thymocytes to undergo an additional layer of testing against tissue-specific antigens, followed by maturation and exit.
  • 2015
    transcribed by T. Bradford Willis, DDS, MSD.
  • 2014 Springer
    by Alexander Schmidt-Richberg.
    Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.
  • 2014
    prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Outcome Sciences, Inc., ; senior editors, Richard E. Gliklich, Nancy A. Dryer ; editor, Michelle B. Leavy.
    This User's Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure.
  • Google Books
    Also available: Print – 1964-
  • 2005 Springer
    Eric Vittinghoff ... [et al.].
    Introduction -- Exploratory and descriptive methods -- Basic statistical methods -- Linear regression -- Predictor selection -- Logistic regression -- Survival analysis -- Repeated measures analysis -- Generalized linear models -- Complex surveys -- Summary.
  • 2009 CRCnetBASE
    Michael Panik.
    Review of fundamental of statistics -- Bivariate linear regression and correlation -- Misspecified disturbance terms -- Nonparametric regression -- Logistic regression -- Bayesian regression -- Robust regression -- Fuzzy regression -- Random coefficients regression -- L1 and q-Quantile regression -- Regression in a spatial domain -- Multiple regression -- Normal correlation models -- Ridge regression -- Indicator variables -- Polynomial model estimation -- Semiparametric regression -- Nonlinear regression -- Issues in time series modeling and estimation.
  • 2002 Wiley
    Benjamin Kedem, Konstantinos Fokianos.
    Time series following generalized linear models -- Regression models for binary time series -- Regression models for categorical time series -- Regression models for count time series -- Other models and alternative approaches -- State space models -- Prediction and interpolation -- Appendix: Elements of stationary processes.
  • 2011
    Manuel Eduardo Lopez, Jr.
    Niemann-Pick disease type C (NPC) is a rare metabolic lysosomal storage disorder (LSD) marked by accumulation of large quantities of cholesterol, lipids and other metabolites in cells. Though the disorder has been extensively explored using various genetic animal models, an understanding of the molecular and cellular pathology of the disease remains limited. A cell-type-specific and regulable rescue mouse model of NPC disease was engineered in order to identify the therapeutically relevant cell type and ascertain the effect of inflammation on disease progression. With the current information presented in this dissertation, a probable road map of NPC disease pathology has been drawn. The road map for NPC may also be applicable to, or act as a template for, other lysosomal storage diseases and neurodegenerative disorders with similar pathologies.
  • 2014 ScienceDirect
    edited by Avi Ashkenazi, Junying Yuan and James A. Wells.
    Examining the molecular mechanism of Bcl-2 family proteins at membranes by fluorescence spectroscopy -- Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry -- The structural biology of BH3-only proteins -- How to analyze mitochondrial morphology in healthy cells and apoptotic cells in Caenorhabditis elegans -- Apoptosis initiation through the cell-extrinsic pathway -- Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway -- Caspase enzymology and activation mechanisms -- Turning on caspases with genetics and small molecules -- A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases -- Measuring caspase activity in vivo -- Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology -- In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe -- Global analysis of cullular proteolysis by selective enzymatic labelling of protein N-termini -- Complementary methods for the indentification of substrates of proteolysis -- Phospholipid scrambling on the plasma membrane -- Studying apoptosis in the zebrafish.
  • 2014 ScienceDirect
    edited by Avi Ashkenazi, James A. Wells and Junying Yuan.
  • 2013 Springer
    David A. Dougan, editor.
    AAA+ proteolytic machines -- Machines of destruction: AAA+ proteases and the adaptors that control them / Eyal Gur, Ralf Ottofueling, David A. Dougan -- The Lon AAA+ protease / Eyal Gur -- FtsH protease-mediated regulation of various cellular functions / Takashi Okuno, Teru Ogura -- Regulatory proteolysis in bacteria -- General and regulatory proteolysis in Bacillus subtilis / Nöel Molière, Kürşad Turgay -- Proteolytic regulation of stress response pathways in Escherichia coli / Dimce Micevski, David A. Dougan -- Regulated proteolysis: control of the Escherichia coli [sigma]E-dependent cell envelope stress response / Sarah E. Barchinger, Sarah E. Ades -- Bacterial proteases and virulence / Dorte Frees, Lone Brøndsted, Hanne Ingmer -- Regulated proteolysis in yeast -- Roles of Cdc48 in regulated protein degradation in yeast / Alexander Buchberger -- The Role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control / Wolfgang Voos, Linda A. Ward, Kaye N. Truscott -- Ubiquitin-like protein modification and protein degradation in microorganisms -- The pup-proteasome system of mycobacterium tuberculosis / Marie I. Samanovic, Huilin Li, K. Heran Darwin -- Archaeal proteasomes and sampylation / Julie A. Maupin-Furlow.
  • 2012
    Weibin Zhang.
    For successful segregation of chromosomes during meiosis, chromosomes have to recognize and align with their correct homologous partners, and then stabilize the homologous alignment with assembly of a proteinaceous structure, called the synaptonemal complex (SC), between them. SC assembly is highly processive and cooperative, yet the SC structure does not distinguish between homologous and nonhomologous associations. Thus SC assembly has to be tightly regulated and coordinated with homologous pairing to ensure that the SC is stabilizing productive homologous associations. Moreover, homologous pairing is accompanied by dramatic chromosome movement and nuclear reorganization of chromosomes into a clustered configuration during C. elegans early meiotic prophase. Subsequently, the clustered chromosomes are redispersed into aligned homologs upon SC assembly. The exact mechanisms involved in regulation and coordination of homologous pairing and synapsis are poorly understood, and this thesis was aimed at gaining a better understanding of the coordination of these two inter-related meiotic events. We identified HAL-2 as a major player in this coordination. We demonstrated that HAL-2 promotes homologous pairing mainly by preventing detrimental effects of SC precursors (SYP proteins). Homologous pairing is not established in hal-2 mutants, and several markers indicative of pairing center-mediated chromosome movement are also absent in hal-2 mutants. Pairing centers (PCs) are cis-acting chromosomal sites that mediate chromosome movement by connecting chromosomes to cytoplasmic microtubules via the conserved SUN-1/ZYG-12 nuclear envelope-spanning complexes. hal-2 mutants also exhibit defective SC assembly, with SYP proteins being loaded inappropriately along single unpaired chromosomes in hal-2 mutants. Moreover markers of PC-mediated chromosome movement and function are coordinately restored in hal-2 mutants by the removal of SYP proteins. Combined with other data, these findings indicate that SYP proteins can inhibit homologous pairing and that HAL-2 promotes pairing largely by antagonizing this inhibition, thus allowing activation and regulation of PC function. Given that HAL-2 concentrates in the nucleoplasm of meiotic germ cells and colocalizes with SYP proteins in nuclear aggregates when SC assembly is prevented, we propose that HAL-2 functions to shepherd SYP proteins prior to licensing of SC assembly, preventing SC precursors from interacting inappropriately with chromosomes and allowing them to accumulate sufficiently for rapid cooperative assembly upon homology verification. In this thesis, we also identified and characterized me16, a hypomorphic allele of scc-3. SCC-3 is a conserved component of the cohesin complex, and the scc-3(me16) mutant was demonstrated to be a partial loss of function mutation by comparative analyses with a null mutant, scc-3(ku263). Besides reduced chromosomal localization of cohesin, scc-3(me16) mutants also display an extended region of clustered chromosomes, incomplete SC assembly and defective recombination. Further, analyses of nuclear aggregates that form in the scc-3(ku263) null mutants led to the findings that components of the lateral elements, including cohesin, colocalize into these nuclear aggregates and that this localization is not dependent on REC-8.
  • 2010
    Sandy Agathe van Gool.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Andrea Elise Hartsock.
    Throughout development cells must go through numerous changes in cell-cell adhesiveness. Within an epithelial layer, cell-cell contacts form and maintenance junctional complexes such as Adherens Junctions, Tight Junctions, and Desmosomes. The Adherens junction (AJ) and Tight junction (TJ) provide important adhesive contacts between neighboring epithelial cells. Although these junctions comprise different proteins, there are similarities in the roles of specialized transmembrane proteins in forming extracellular adhesive contacts between cells, and intracellular links to the actin cytoskeleton and signaling pathways including the regulation of gene transcription. The Adherens junction performs multiple functions including initiation and stabilization of cell--cell adhesion, regulation of the actin cytoskeleton, intracellular signaling and transcriptional regulation. The core of the Adherens junction includes interactions among transmembrane glycoproteins of the classical cadherin superfamily, such as E-cadherin, and the catenin family members including p120-catenin, [Beta]-catenin, and [Alpha]-catenin. Together, these proteins control the formation, maintenance and function of adherens junctions. Tight junctions have been proposed to have two mutually exclusive functions: a fence function which prevents the mixing of membrane proteins between the apical and basolateral membranes; and a gate function which controls the paracellular passage of ions and solutes in-between cells. Tight junctions contain two types of transmembrane proteins, occludins and claudins, which confer these functions, and associated cytoplasmic proteins that may link tight junctions to the actin-cytoskeleton and the adherens junction. Adherens Junction mediated cell--cell adhesion is highly dynamic enabling the reorganization and dispersal of cells, for example, during epithelial-to-mesenchymal transition in normal development and carcinogenesis. p120-Catenin binding to, and Hakai (an E3 ubiquitin ligase)-mediated ubiquitination of the juxtamembrane domain (JMD) of E-cadherin are thought to be involved in regulating E-cadherin internalization and degradation. However, the relationship between these two pathways is not known. The aim of my project was to determine if p120-catenin/E-cadherin and Hakai dependent ubiquitination of E-cadherin are mechanistically linked. We targeted the E-cadherin JMD to mitochondria (WT-JMD) to isolate this domain from the plasma membrane and internalization, and to examine protein modifications and degradation. WT-JMD was targeted to mitochondria, but it did not accumulate there except when proteasome activity was inhibited. We found that WT-JMD was ubiquitinated, and arginine substitution of lysines at position 5 (K5R) and 83 (K83R) resulted in the stable accumulation of mutant JMD at mitochondria. p120-Catenin did not localize, or bind to WT-JMD even upon proteasome inhibition, whereas the K5,83R JMD mutant bound p120-catenin and localized it to mitochondria. Mutation of the p120-catenin binding site in combination with these lysine mutations inhibited p120-catenin bind-ing, but did not decrease JMD stability or its accumulation at mitochondria. Further-more, over-expression of Hakai resulted in inhibition of p120-catenin binding to WT-JMD. Thus, increased stability of JMD lysine mutants was due to inhibition of ubiquitination and not to p120-catenin binding. Finally, mutation of these critical lysines in full length E-cadherin had the same effects on protein stability as mitochondria-targeted E-cadherin JMD. Our results indicate that ubiquitination of the JMD inhibits p120-catenin binding, and targets E-cadherin for degradation via the proteasome. Further work needs to be done to test our hypothesis that p120-catenin stabilizes E-cadherin by masking ubiquitination sites within E-cadherin-JMD.
  • 2009
    Hector Y. Caro-Gonzalez.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Jose Rafael Morillo Prado.
    Many adult tissues with short-lived cells such as blood and skin require a constant replacement of aging cells. This process is often accomplished by adult stem cells, both self-renew and give rise to differentiating progeny. The process of self-renewal and differentiation must be tightly controlled: failure to self-renew results in the loss of the stem cell population, and lack of differentiation impairs tissue function with dire consequences to the organism. The fate decisions of stem cells are guided by the interaction between extracellular signals from the local microenvironment and intrinsic factors that set the state of the cell, many of which are coordinated by transcriptional programs that are, in turn, is controlled by posttranslational modifications of histones or replacement of canonical histones with histone variants. Polycomb group (PcG) proteins partake in the modification of histones and influence the transcriptional state of genes. PcG proteins are involved in transcriptional regulation by inducing the methylation and ubiquitination of histone tails, which maintain the repression of target genes through cell divisions. Emerging evidence indicates that replacement of canonical histones with histone variants is also important in cell fate decisions. Here I show that PcG proteins Psc and Su(z)2 restrict proliferation and maintain the identity of the cyst stem cell (CySC) lineage in the Drosophila testis. Loss of Psc and Su(z)2 gene function in CySC but not in the germline stem cell (GSC) lineage resulted in the formation of a tumor composed of proliferative mutant cells of abnormal identity, likely due to the derepression of the Hox gene Abdominal-B. The resulting formation of tumor-like masses of proliferative cells interfered non-cell autonomously with maintenance of the germline most likely by displacing GSCs from their niche. I also show that the histone variant His2Av is required cell-autonomously for maintenance of adult stem cells in both somatic and germ cell lineages. GSCs lacking His2Av function were lost over time. Surprisingly, GSCs null mutant for His2Av gave rise to germ cells that underwent normal transit amplification divisions and differentiation to spermatocytes and spermatids. Similarly, CySCs lacking His2Av were also lost over time, but were able to give rise to differentiated cyst cells. My results indicate that His2Av and Stat92E likely maintain GSCs and CySCs independently. His2Av mutant GSCs expressed Stat92E and had properly oriented centrosomes, while Stat92E mutant GSCs expressed His2Av. My results expand knowledge chromatin states required for adult stem cell function, showing, for the first time, that a histone variant has a unique role in maintaining stem cells.
  • 2012
    Alicia Roberta Shields.
    Adult stem cells generate short-lived but highly differentiated cells that maintain and repair tissues which exhibit high turnover rates or tissues prone to wear and tear including sperm, skin, blood, intestinal epithelium and muscle. Adult stem cells typically reside in specialized microenvironments or stem cell niches, and a major goal of stem cell biology is to understand how these specialized microenvironments regulate adult stem cell self-renewal, proliferation and differentiation to maintain tissue homeostasis. Drosophila spermatogenesis provides an in vivo model system to investigate how the niche governs adult stem cell behavior. At the apical tip of the Drosophila testis, a cluster of post-mitotic support cells called the hub maintains two adult stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Hub cells secrete the Unpaired ligand, which activates JAK-STAT signaling in the neighboring GSCs and CySCs. JAK-STAT signaling and coordinated crosstalk between the germ line and soma together maintain GSCs and CySCs within the stem cell niche and direct proper association between their differentiating daughter cells. In this dissertation, I address two questions: (1) how a putative gene target of JAK-STAT influences stem cell self-renewal and maintenance and (2) how a transcriptional co-activator controls stem cell differentiation. To investigate the mechanism by which JAK-STAT signaling regulates GSC maintenance, I probed the function of profilin, a regulator of filamentous actin (F-actin). Profilin had been identified as a STAT target gene in the testis stem cell niche by performing chromatin immunoprecipitation with antibodies against phosphorylated STAT (activated STAT), followed by high throughput sequencing (ChIP-Seq) (Davies et al., submitted). It was already known that profilin mutants lose early germ cells (Gönczy and DiNardo, 1996) but the germline stem cell phenotype had not been characterized. I showed that GSCs were lost throughout development with markedly reduced GSC numbers in testes from late third instar larval hypomorphs and strong loss-of-function profilin mutants. By performing clonal analysis with null profilin alleles, I found that wild-type function of profilin was required cell autonomously for GSC maintenance. GSCs homozygous mutant for profilin detached from the hub and differentiated. F-actin and Adenomatous Polyposis Coli 2 (APC2) localization at the hub-GSC interface was disrupted in testes from profilin mutants. Interestingly, germline specific over-expression of APC2 rescued GSC loss in profilin hypomorphs. My studies suggested that profilin may be indirectly required to stabilize APC2 and [beta]-catenin at E-cadherin-based adherens junctions between hub cells and GSCs. Intercellular conversations between the germ line and the soma regulate the behavior of the stem cells in both lineages. I showed that a mutation in the MED20 gene, which encodes one of the subunits of Mediator, a multiprotein complex that acts as an interface between gene-specific regulatory proteins and the general transcriptional machinery to stimulate transcription, resulted in over-proliferation of both germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Mediator function was required cell autonomously for CySCs to differentiate into somatic cyst cells, and non-autonomously for germ cell differentiation. This study reinforced the importance of crosstalk between stem cell lineages that work together to maintain tissue homeostasis.
  • 2016 Springer
    edited by Sajal Chakraborti, Naranjan S. Dhalla.
  • 2006 Springer
    edited by A-Majid Khatib.
  • 2010
    Craig Betts.
    The centromere is a specialized chromatin domain that is required for kinetochore formation and chromosomal attachment to the mitotic spindle. In higher eukaryotes, centromere identity is independent of the underlying DNA sequence and is thought to be propagated through epigenetic mechanisms. One of the defining features of centromeric chromatin is the presence of the histone H3 variant CENP-A, which is localized exclusively at centromeres. Many fields of evidence suggest that CENP-A incorporation serves as the epigenetic mark maintaining centromere identity. CENP-A loading is under strict temporal control, and unlike conventional histones is uncoupled from DNA replication; instead, CENP-A is loaded exclusively during late anaphase through earl G1 of the cell cycle. Uncovering the mechanisms that control the precise timing and exclusive localization of CENP-A incorporation will deepen our understanding of aspects fundamental to cell division and epigenetics. In order to take an unbiased approach to discovering genes involved in centromeric function, we undertook a whole genome RNAi screen in Drosophila looking for genes whose depletion resulted in a loss of CENP-A phenotype. In our screen, we discovered that the constitutive centromere protein CENP-C and newly discovered protein CAL1 were in a complex with CENP-A and required CENP-A loading. Additionally, we discovered that RNAi of the drosophila homologues of EMI1 and Cyclin A result in a loss of CENP-A through premature activation of the anaphase promoting complex (APC), which we theorized resulted in the destruction of an unidentified APC substrate required for CENP-A loading. Intrigued by the connection between the timing of CENP-A loading and APC activation, we adapted an in-vitro degradation assay to assess the possibility that Drosophila CENP-A, CENP-C, or CAL1 could be our theorized APC substrate. Our assay indicated that these Drosophila proteins are not APC substrates. This finding led us to screen a candidate pool of 20 human proteins implicated in centromere function. Our screen discovered that HsKNL2/M18BP1, an essential centromere protein required for CENP-A loading, is an in-vitro substrate of the anaphase promoting complex. KNL2 degradation is mediated through destruction box (D-Box) and KEN box motifs. Mutation of the KEN and D-Boxes confers stability to KNL2 both in-vitro and in-vivo. Additionally, we discovered that centromeric localization of KNL2 depends on conserved residues in its SANTA (SANT-Associated) domain. Expression of GFP-nondegradable-KNL2 is able to rescue the CENP-A loading defect of KNL2 siRNA, indicating that KNL2 removal by the APC is not required for CENP-A loading. Further experiments are ongoing to characterize the phenotypic effects of KNL2 stabilization, particularly whether KNL2 stabilization is sufficient to decouple CENP-A loading from the cell cycle. We are also testing models to explain KNL2's localization to centromeres during periods of high APC activity and their consequences to centromere function. The discovery that KNL2 is an APC substrate provides a mechanistic link to explain the carefully regulated timing of CENP-A loading. Through a multidisciplinary approach we have assigned novel roles to genes required for CENP-A assembly in Drosophila; we further extended those principles to human biology and have possibly uncovered a mechanistic explanation for CENP-A's unique loading dynamics.
  • Google Books
    Also available: Print – pt. 1, 1972.
  • 2009
    Daniel Joseph Hogan.
    Circumstantial evidence suggests vast post-transcriptional regulatory networks in eukaryotes. There are scores of examples of mRNAs with rich post-transcriptional lives, and dozens of RNA-binding proteins and noncoding RNAs are suggested to have regulatory functions. While eukaryotic genomes encode hundreds of RNA-binding proteins and metazoans also encode dozens to hundreds of regulatory noncoding RNAs, few RNA-binding proteins or regulatory noncoding RNAs have been studied systematically, leaving unanswered basic questions about the scope and organization of post-transcriptional regulation in any eukaryote. First, I present studies aimed at uncovering some of the basic principles of post-transcriptional regulation in eukaryotes, via searching for the RNA targets of 40 proteins in the yeast Saccharomyces cerevisiae: a selective sample of the approximately 600 annotated and predicted RBPs as well as several proteins not annotated as RBPs. Second, I present a simple biochemical approach to identify direct targets of specific microRNAs, important noncoding regulatory RNAs, that regulate protein synthesis of most mammalian mRNAs. Third, I present experiments that uncover the magnitude and respective contributions of translational repression and mRNA decay of microRNA-mediated regulation. These studies apply simple, yet powerful approaches to systematically dissect various aspects of post-transcriptional regulation and uncover a wealth of novel information regarding regulation by RNA-binding proteins and microRNAs.
  • 2009 CRCnetBASE
    edited by Rajesh K. Gaur and John J. Rossi.
    Micro mining : computational approaches to miRNA discovery / Adam Grundhoff -- Animal microRNA gene prediction / Ola Snv?e and Pa<U+030a>l St?rom -- A suite of resources for the study of miRNA ontology and function / Praveen Sethupathy, Molly Megraw, and Artemis G. Hatzigeorgiou -- Regulation of translation and mRNA stability by Hfq-binding small RNAs in Escherichia coli / Hiroji Aiba -- Mechanisms by which microRNAs regulate gene expression in animal cells / Yang Yu and Timothy W. Nilsen -- The microRNAs of C. elegans / Mona J. Nolde and Frank J. Slack -- Isolation and characterization of small RNAs in C. elegans / Chisato Ushida and Yusuke Hokii -- MicroRNA tales in fly development / Utpal Bhadra ... [et al.] -- RNA interference and miRNAs in zebrafish / Alex S. Flynt, Elizabeth J. Thatcher, and James G. Patton -- Biogenesis and function of plant microRNAs / Zoltan Havelda -- Endogenous small RNA pathways in Arabidopsis / Manu Agarwal, Julien Curaba, and Xuemei Chen. How to assay miRNA expression : a technology guide / Mirco Castoldi, Vladimir Benes, and Martina U. Muckenthaler -- Methods to quantify microRNA gene expression / Lori A. Neely -- Regulation of alternative splicing by microRNAs / Rajesh K. Gaur -- Recent progress in polymerase II-mediated intronic microRNA expression systems / Shi-Lung Lin and Shao-Yao Ying -- MicroRNA-based RNA polymerase II expression vectors for RNA interference in mammalian cells / Anne B. Vojtek ... [et al.] -- Transgenic RNAi : a fast and low-cost approach to reverse genetics in mammals / Linghua Qiu and Zuoshang Xu -- Symphony of AIDS : an miRNA-based therapy / Yoichi R. Fujii -- MicroRNAs and cancer : connecting the dots / Sumedha D. Jayasena -- Mammalian transcriptional gene silencing by small RNAs / Daniel H. Kim and John J. Rossi -- Regulation of gene expression by RNA mediated transcriptional gene silencing / Kevin V. Morris.
  • 2007 Springer
    edited by Carole L. Bassett.
  • 2013
    Jaclyn Geok Yueen Lim.
    Adult stem cells are undifferentiated cells that are capable of both self-renewal and differentiation into a variety of specialized cells. Adult stem cell lineages have been identified in several organs including skin, blood, breast, intestine, bladder, skeletal muscle, prostate, and the testes. The changes in homeostatic conditions in these organs caused by tissue turnover or injury rely heavily on the pool of adult stem cells for cell replenishment. Therefore, the activity of adult stem cells must be tightly controlled, and many of these regulations are orchestrated by the stem cell niche, the local microenvironment in which stem cells reside. The fast generation cycle and the genetic tractability of fruit flies make the Drosophila testis stem cell niche an ideal system for the study of adult stem cell regulation. The Drosophila testis maintains two types of stem cells: germline stem cells (GSCs) which give rise to sperm, and cyst stem cells (CySCs) which differentiate into cyst cells that encapsulate germ cells. The somatic cyst cell lineage has been implicated to be required at several stages of spermatogenesis and play pivotal roles in germline proliferation, survival, and differentiation. This dissertation focuses on understanding the role of the cyst cell lineage in GSC maintenance and investigating the mechanisms by which cyst cells direct early germ cell differentiation. Previously, it has been proposed that CySCs are the source of instructive self-renewal cues for GSCs. In contrast to this model, I showed that early germ cells with GSC characteristics can be maintained in the absence of CySCs and cyst cells. These germ cells failed to enter the transit-amplifying program, which is regarded as the first step of differentiation in many adult stem cell lineages. My observations suggest that cyst cells provide a pro-differentiation environment for GSCs, and that this mechanism(s) may be repressed in CySCs which indirectly allow for GSC self-renewal. Encapsulation of germ cells by cyst cells is one of the differentiation-promoting mechanisms imposed by the soma on the germline, and I have uncovered that this process requires activation of the EGFR-Ras-MEK-MAPK pathway in differentiated cyst cells. Furthermore, I also showed that repression of EGFR activation in CySCs is important in maintaining the population of GSCs and CySCs at the niche, as premature activation of the pathway resulted in displacement of GSCs from the hub by somatic cells. Preliminary studies revealed a STAT target gene, Socs36E as a negative regulator of the EGFR pathway in CySCs to prevent out-competition of GSCs by somatic cells. To understand how the somatic cyst cells germline differentiation, I performed two genetic screens: an RNAi screen of genes that caused premature germ cell differentiation when misexpressed in the soma, and a misexpression screen of genes predicted to be cell-surface and secreted proteins. Three promising candidates were identified through these screens: two ribosomal subunits, Rpl13A and RpS10a; and a septate junction component, Neurexin IV. The two ribosomal proteins may be involved in the soma to promote germ cell encapsulation. Neurexin IV however, operates non-cell autonomously in cyst cells to regulate germ cell differentiation into spermatocytes. Together, the results of this dissertation emphasize the importance and complexity of the interaction between adult stem cells and their microenvironment in maintaining tissue homeostasis.
  • 2010
    Kenneth Demire Gibbs, Jr.
    Hematopoiesis is organized as a cellular hierarchy in which long-term self-renewing hematopoietic stem cells (HSC) give rise to all lineages of blood cells for the lifetime of an organism. Following the prospective isolation of mouse HSC in the late 1980s, research over the past two decades has focused on refining the phenotypic compartment where HSC reside, and identifying the numerous cell intrinsic and extrinsic mechanisms important for their maintenance. Many of these pathways are misappropriated in hematopoietic malignancies such as leukemia. It has been proposed that like normal hematopoiesis, leukemia is organized as a cellular hierarchy in which a leukemic stem cell population (LSC) is uniquely able to self-renew and gives rise to the heterogeneous lineages of cells that compose the tumor. This thesis will cover the mechanisms regulating the behavior of normal hematopoietic stem cells and leukemic stem cells. First, phospho-specific flow cytometry was utilized to define the responsiveness of human HSC to cytokine stimulation. This direct biochemical analysis demonstrated that HSC respond directly and rapidly to a broader number of direct stimuli in vitro and in vivo than previously appreciated. This included Granulocyte Colony Stimulating Factor (G-CSF), a cytokine used clinically to mobilize HSC to the peripheral blood prior to bone marrow transplantation. The direct HSC response to G-CSF is shown to affect the behavior of the HSC pool in vitro (causing cell cycle entry and increased proliferation), and in vivo (negatively regulating active hematopoiesis in the short-term). Thus, it is proposed that cytokines, long known to impact the function of mature lineage cells, also are important for the steady-state regulation of HSC activity. Next, two mouse models of AML were utilized to determine the mechanisms important for regulation of LSC activity. It is demonstrated that the catalytic p110[lower case delta] subunit of Phosphoinositide 3-kinase (PI3K), which is constitutively activated and drives proliferation in human AML blasts, is dispensable for de novo leukemogenesis and LSC activity in AML driven by retroviral transfer of MLL-AF9 or HoxA9-Meis1 (H9M) oncogenes into early hematopoietic progenitors. Finally, the LSC in H9M AML are identified. Surprisingly, multiple phenotypic compartments were equally enriched for LSC activity. This was also the case when LSC activity in MLL-AF9 driven AML was assessed. Putative genetic LSC maintenance signatures for each model were also identified. There was both overlap and stark contrast in cell surface phenotypes of the LSC-enriched compartments and the genetic LSC maintenance signatures in these closely related leukemias. These data suggest that like normal hematopoiesis, a hierarchy does exist in which self-renewing cells give rise to terminally differentiated progeny. However, unlike HSC activity, which can be isolated to a single compartment by cell surface phenotype that is commonly regulated between individuals, LSC activity is a cell state that can be independent of surface phenotype and with context-specific regulatory mechanisms.
  • 2011
    Michael Wong.
    Naïve CD4+ T cells are precursor cells that differentiate into distinct lineages of T helper (TH) cells upon cellular activation. The work presented here describe how we identified the soluble factors required for the differentiation of human TH17 and TH9 cells, which are two novel TH subsets implicated in the pathogenesis of various autoimmune and allergic disorders, respectively. We also performed functional analysis with human TH1, TH2 and TH17 cells, demonstrating that different TH cells drive monocytes to differentiate into specialized DC subsets. Collectively, we believe that these data have significant implications for the treatment of inflammatory disorders. In order to determine the factors that drive human TH17 differentiation, we hypothesized that a subset of TLR ligands could induce PBMCs to secrete TH17-polarizing factors. We identified that conditioned media from TLR4- and TLR8/7-stimulated cultures could promote IL-17 production. Using a proteomics screening approach, we demonstrated that a combination of pro-inflammatory cytokines synergistically promote human TH17 differentiation. TH17-polarizing cytokines upregulated the expression of the transcription factor ROR[Gamma]t and drove the expansion of memory TH17 and TH1/17 cells. The data presented in Chapter 2 indicate that the pathways driving murine and human TH17 responses are quite different, which may diminish the value of various mouse studies in the treatment of TH17-driven diseases. In collaboration with the laboratory of Edgar Engleman, we demonstrate that TH cells mediate the differentiation of monocytes into distinct DCs. Importantly, TH17 cells drive the formation of TH17-promoting DCs (DCTh17), whereas TH1 and TH2 cells drive the formation of TH1- and TH2-promoting DCs (DCTh1 and DCTh2), respectively. Blocking the TH1 cytokine IFN-[Gamma] inhibited DCTh1 formation, whereas neutralizing the TH2 cytokines IL-4 and IL-13 inhibited DCTh2 formation. Studies of psoriasis and atopic dermatitis skin lesions indicate that TH cells are closely associated with monocytes and DCs in situ, suggesting that this pathway contributes to disease pathogenesis. These data illustrate a positive feedback loop between TH cells, monocytes and DCs that may contribute to the ongoing inflammation observed in various autoimmune and allergic disorders. In Chapter 4, the factors that promote human TH9 differentiation are characterized, and we provide evidence that IL-21 is a potent enhancer of IL-9 secretion. TH9 cells generated in vitro exhibit a heterogeneous phenotype based on the expression of the transcription factors GATA-3 and Foxp3. Finally, a small population of memory CD4+ T cells cultured under TH17-polarizing conditions secreted IL-9, IL-17 and IFN-[Gamma], suggesting considerable lineage plasticity among human TH cells. Taken together, these data indicate a complex cytokine network in the regulation of human TH17 and TH9 cells.
  • 2015 Springer
    Rodney D. Geisert, Fuller W. Bazer, editors.
    Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics, along with the ability to selectively knockout genes of interest, have greatly advanced our understanding of the maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides the basis for new research endeavors to address infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. This book brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. The reviews provide readers with the latest knowledge on the role of the endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved in the regulation of conceptus development. .
  • 2010
    Eon Joseph Rios.
    Cell surface receptor regulation maintains proper responses to external signals and disregulation of receptors can have drastic effects. We found that RabGEF1, a guanine exchange factor (GEF) for the endocytic regulating small GTPase Rab5, regulates IgE+antigen (Ag)-induced Ras signaling in mast cells and skin homeostasis in vivo. To further understand RabGEF1's role in mast cell function we investigated if RabGEF1 generally regulates mast cell signaling by examining a number of modes of mast cell activation. Like IgE+Ag stimulation, RabGEF1 deficient (-/-) mast cells demonstrated enhanced activation after exposure to stem cell factor (SCF), the ligand for the receptor tyrosine kinase c-kit. Enhanced responses correlated with delayed c-kit and IgE receptor (FcεRI) internalization suggesting a proximal role of RabGEF1 in regulating mast cell signaling events. To dissect the roles of RabGEF1 and its domains in regulating mast cell biology we lentivirally expressed a panel of RabGEF1 mutants in RabGEF1-/- mast cells. We found that RabGEF1 (1) harbors ubiquitin (Ub) ligase activity within an N-terminal A20 zinc finger domain, (2) binds to Ub and localizes to membranes through amino acids 1-150, (3) interacts with Rabaptin-5, a Rab5 effector, through a C-terminal coiled coil (CC) domain and, (4) activates Rab5 with a central VPS9 domain. Despite containing a number of domains, only the VPS9 was crucial to restore wildtype activation of RabGEF1-/- cells after IgE+Ag stimulation. Moreover, lack of the VPS9 or CC domain diminished Rabaptin-5 levels and reduced surface FcεRI and β1 expression on mast cells suggesting that these domains are important for receptor homeostasis. Using shRNA knockdown of Rabaptin-5 we identified a novel role for Rabaptin-5 in maintaining FcεRI and β1 surface expression by increasing surface stability and receptor half-life. The reduced FcεRI and β1 surface levels in Rabaptin-5 deficient cells attenuated sensitivity to antigen induced adhesion, migration, and cytokine production in these cells. Despite Rabaptin-5's in vitro documented role as a Rab5 effector, Rab5 dependant processes (i.e., receptor internalization or endosome fusion) were unaffected by Rabaptin-5 deficiency and challenge the current thoughts of Rab5 processes in intact cells. These data show the importance of receptor trafficking in regulating mast cell activation.
  • 2012
    Simona Rosu.
    Sexually reproducing organisms undergo meiotic recombination to increase genetic diversity and to ensure correct segregation of chromosomes at the first meiotic division. During meiotic recombination, DNA double-strand breaks (DSBs) are deliberately induced, and a subset of the breaks are repaired as inter-homolog crossovers (COs). Inter-homolog COs provide physical connections between homologous chromosomes that enable them to segregate away from each other. Despite reliance on COs for chromosome segregation, few COs are made per chromosome pair, implying mechanisms for robust CO control. In addition, DNA breaks are potentially dangerous lesions, therefore DSB formation and repair must be tightly regulated, both to ensure the formation of COs, but also to protect against deleterious effects. This thesis provides new insights into mechanisms that regulate DSB formation and repair, using the nematode Caenorhabditis elegans as a model organism. CO regulation mechanisms were probed by monitoring the repair outcome of a DSB induced at a defined site at different stages of meiotic progression, in WT and mutant situations. This analysis uncovered a previously unappreciated level of control in restricting CO number, which is to limit the duration of access to the homolog as a repair template. In addition, this work showed that when no competing breaks are present, a single induced DSB is converted to a CO with high efficiency. This feature helps achieve CO assurance. Insights into regulation of DSB formation were uncovered from the identification and characterization of novel protein DSB-2. DSB-2 is required for break formation, but is dispensable for later steps of meiotic recombination. DSB-2 localizes to chromatin during the time of break formation, suggesting it acts to promote competence for DSB formation. Both approaches presented in this thesis uncovered evidence for negative feedback regulatory mechanisms, suggesting a model wherein formation of CO-eligible recombination intermediates signals shutdown of DSB formation as well as shutdown of inter-homolog access. The proposed regulatory networks provide a mechanism to both ensure sufficient breaks and COs are made, and to shut down these processes to prevent deleterious effects as meiosis progresses.
  • 2016 Springer
    Sajal Chakraborti, Naranjan S. Dhalla, editors.
  • 2011 Springer
    edited by Helge Grosshans.
    MicroRNA biogenesis and function : an overview / Rene F. Ketting -- Regulation of pri-miRNA processing through Smads / Akiko Hata and Brandi N. Davis -- Stimulation of pri-miR-18a processing by hnRNP A1 / Gracjan Michlewski, Sonia Guil, and Javier F. Cáceres -- KSRP promotes the maturation of a group of miRNA precursors / Michele Trabucchi ... [et al.] -- Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor / Sally Fujiyama-Nakamura, Kaoru Yamagata, and Shigeaki Kato -- Autoregulatory mechanisms controlling the microprocessor / Robinson Triboulet and Richard I. Gregory -- Regulation of pre-miRNA processing / Nicolas J. Lehrbach and Eric A. Miska -- The effect of RNA editing and ADARs on miRNA biogenesis and function / Bret S.E. Heale, Liam P. Keegan, and Mary A. O'Connell -- MiRNAs need a trim regulation of miRNA activity by trim-NHL proteins / F. Gregory Wulczyn ... [et al.] -- Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression / Nicole-Claudia Meisner and Witold Filipowicz -- Turnover of mature miRNAs and siRNAs in plants and algae / Heriberto Cerutti and Fadia Ibrahim -- MicroRNases and the regulated degradation of mature animal miRNAs / Helge Grosshans and Saibal Chatterjee.
    Also available: Print – 2010
  • 2010
    Michael R. Howitt.
    Microbes can colonize harsh and dynamic environments. Often, this ability depends on rapid responses through directed motility. Members of the Epsilon proteobacteria are found in many 'extreme' environments, including the human stomach. We discovered that Helicobacter pylori establish bacterial colonies deep in the gastric glands, and identified a novel protein, ChePep, necessary to colonize this niche. By tracking the movement of single bacteria we found that mutants lacking ChePep cannot control the rotation of their flagella and swim with abnormally frequent reversals and even sustain bursts of movement backwards. Genetic experiments show that ChePep regulates flagellar rotation through the chemotaxis signaling system. By examining H. pylori within a microscopic pH gradient, we determined that ChePep is critical for normal chemotactic behavior. We expressed ChePep from the zoonotic pathogen Campylobacter jejuni, and the deep sea hydrothermal vent inhabitant Caminibacter mediatlanticus in H. pylori and found that ChePep is functionally conserved across the [epsilon]-proteobacteria. ChePep represents a new family of chemotaxis regulators unique to the [epsilon]-proteobacteria, and illustrates the differing strategies that microbes have evolved to control motility.
  • 2006
    Everett Hurteau Meyer.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Stephani Sara Dean.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Saul Abraham Villeda.
    Aging in mammals is associated with a decline in the function and regenerative capacity of tissue specific stem cells. In the adult central nervous system the age-related decline of these functional stem/progenitor cells (NPCs), and subsequently neurogenesis, is correlated with impairments in cognitive functions including learning and memory. Interestingly, changes occurring in the systemic milieu of an organism, such as those induced through increased exercise, have been shown to partially mitigate this cellular decline. While previous studies have examined intrinsic molecular mechanisms underlying NPC aging and decreased neurogenesis at the cellular level, a gap still exists in elucidating how age-dependent NPC function is impaired by systemic changes associated with aging. This dissertation addresses the role of the aging systemic milieu in the regulation of adult neurogenesis and cognition, and seeks to identify individual factors responsible in part for the age-related decline. Chapter 1 reviews the cellular process of adult neurogenesis and discusses its regulation during aging by intrinsic and extrinsic factors, as well as its contribution to synaptic plasticity and cognitive functions. Chapter 2 focuses on the age-related decrease in adult neurogenesis and asks whether systemic molecular changes naturally occurring with age contribute to this decline. Using heterochronic parabiosis, in which the circulatory systems of two animals are adjoined, we show that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age dependent fashion in mice. Furthermore, we demonstrate functional relevance for changes occurring in the systemic milieu, as exposing a young animal to an old systemic environment, or to plasma from old mice, decreased synaptic plasticity and impaired spatial learning and memory. Chapter 3 focuses on individual systemic factors and demonstrates that age-related changes in systemic chemokine levels negatively regulate neurogenesis and learning and memory. Using a targeted proteomic screen, we identified a conserved subset of blood borne chemokines - including CCL2/MCP-1 and CCL11/Eotaxin -- whose plasma levels correlate with reduced neurogenesis observed in normal and experimental (i.e. heterochronic parabiosis) aging. Additionally, mimicking an aged systemic environment by increasing the level of CCL11 in the periphery of young adult mice resulted in a decrease in neurogenesis and impaired spatial learning and memory. Chapter 4 focuses on [Beta]2-microglobulin (B2M), another identified systemic factor that increases with aging and negatively correlates with the age-related decline in neurogenesis, and examines its role in regulating adult hippocampal neurogenesis. Using primary cell models we show that exposure to recombinant B2M protein inhibits NPC function and neuronal differentiation in vitro. Furthermore, we show that local exposure of a young adult hippocampus to B2M decreases neurogenesis and impairs cognitive function in vivo. Additionally, we show that the inhibitory effects of B2M are mediated by MHCI. Lastly, using a genetic mouse model that lacks B2M expression we show that neurogenesis is improved in adult animals in an age-dependent manner. Chapter 5 contains a summary and conclusion of the results presented in this dissertation, highlighting the influence of the aging systemic milieu on neuroplasticity and cognition.
  • 2006
    Rachel Gail Henderson.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Odmara Liz Barreto-Chang.
    Electrical activity is a potent trophic factor that promotes the survival of many populations of neurons. L-type calcium channels (LTCs) are particularly effective at promoting survival of neurons during development, in part by activating transcription factors such as CREB. Mutation of the LTC CaV1.2 causes Timothy Syndrome (TS), a disorder characterized by cardiac arrhythmias, webbing of fingers and toes, and autism. The TS mutation leads to loss of voltage-dependent inactivation (VDI) of the channel. Although it is known that VDI is critical for the transition between the open and resting states of the channel, the role that channel inactivation plays in cell signaling and neuronal development is poorly understood. The work in this dissertation shows that the TS mutation impairs CaV1.2-dependent neuronal survival and prevents activation of the transcription factor CREB. By using TS channels that contain pore mutations that prevent Ca2+ flux, we found that the ability of TS channels to cause apoptosis is independent of Ca2+ flux through the channel. Conversely, a novel leucine to proline mutation at position 1368 restores VDI to TS channels and prevents TS-dependent apoptosis and inhibition of CREB. These findings support the idea that CaV1.2 conveys two signals that together regulate activity-dependent neuronal survival and activation of CREB: a signal that depends on the channel conformation and a signal that depends on calcium influx through the channel. These results provide new insights into the mechanisms by which the L-type calcium channels activate transcription and regulate neuronal survival during development.
  • 2001 ScienceDirect
    edited by John T. Romeo, James A. Saunders, and Benjamin F. Matthews.
  • 2005 Springer
    R. Brehm, K. Steger.
  • 2012
    Christopher Paul Arnold.
    Stem cell self-renewal is dynamically regulated in response to extrinsic stimuli, but the intrinsic mechanisms that mediate the effects of these stimuli remain elusive. Emerging evidence suggests that miRNAs, an abundant class of ~22-nt small regulatory RNAs, play key roles in controlling the post-transcriptional genetic programs in stem and progenitor cells. We systematically examined miRNA expression profiles in various normal and aberrant adult tissue-specific stem and progenitor cells. Delineation of miRNAs whose expression correlated with changes in the self-renewal properties during normal development and as the result of mutant perturbations permitted the identification of miRNAs that marked stem to progenitor transition, termed SPT-miRNAs. Expression of SPT-miRNAs correlated with the exit from a self-renewing state as well as reduced self-renewal capacity in various normal and leukemia stem cells, suggesting that they may play a role in post-transcriptional gene silencing of key mediators of stem cell self-renewal. Consistent with this hypothesis, premature expression of a subset of these miRNAs could diminish the reconstitution potential of hematopoietic stem cells (HSCs) and the self-renewal of embryonic stem cells (ESCs). Furthermore, SPT-miRNAs targeted genes necessary for the self-renewal of HSCs, suggesting that up-regulation of these miRNAs permitted the efficient silencing of self-renewal programs during the stem to progenitor transition. Given the functional overlap of SPT-miRNAs in both embryonic and adult stem cells, we hypothesized that the expression of some SPT-miRNAs may be actively repressed by extrinsic signaling cues in stem cells at multiple developmental stages to potentiate their self-renewal. By subjecting ESCs to various culture conditions that diminished their self-renewal efficiency, we observed an up-regulation of a subset of SPT-miRNAs; in particular, members of the miR-181 family. Ectopic expression of this miRNA reduced ESC self-renewal whereas its deletion augmented ESC self-renewal in serum-free medium. These changes in self-renewal were attributable to simultaneous modulation of ESC proliferation and lineage commitment via target interactions with Lin28A, Spry4, and Dusp6. Finally, we found that the BMP-signaling pathway, necessary for the efficient self-renewal of ESCs, played a key role in the suppression of miR-181a. Collectively, these results reveal how extrinsic signaling cues mediate the quantitative post-transcriptional regulation of stem cell self-renewal programs via the modulation of miRNAs. Our study demonstrated one approach to identify and investigate the role of intrinsic regulators and provided novel insight into how to uncover the intrinsic regulators of stem cell self-renewal with implications on manipulation of stem cell expansion ex vivo.
  • 2010
    Daniel Richard Calnan.
    The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme longevity in humans and to regulate the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. The activity of FoxO3 is controlled by a variety of post-translational modifications that have been proposed to form a 'code' affecting FoxO3 subcellular localization, DNA binding ability, protein-protein interactions and protein stability. Lysine methylation is a key post-translational modification on histones that regulate chromatin accessibility and is a key part of the 'histone code'. However, whether lysine methylation plays a role in modulating FoxO3 activity has never been examined. I found that the methyltransferase Set9 directly methylates FoxO3 in vitro and in cells. Using a combination of tandem mass spectrometry and methyl-specific antibodies, I find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1. Methylation of FoxO3 by Set9 decreases FoxO3 protein stability, while slightly increasing FoxO3 transcriptional activity. The modulation of FoxO3 stability and activity by methylation may be critical for fine-tuning cellular responses to stress stimuli, which may in turn affect FoxO3's ability to promote tumor suppression and longevity. Post-translational modifications control many aspects of FoxO3 activity, including protein stability, subcellular localization and binding partner association. To analyze whether FoxO3 functions primarily alone, or in a complex with other factors, I used size exclusion chromatography to assess the size of the potential FoxO3 protein complexes in cellular extracts. I found that FoxO3 is present in fractions with a relative molecular weight larger ranging from 250 to 700 kDa. Interestingly, the cytoplasmic fraction of FoxO3 appears to be in a larger complex than the nuclear fraction, suggesting that FoxO3 is present in more than one protein complex in cells. To identify novel binding partners of FoxO3 that could be present in these large molecular-weight protein complexes, I conducted a tandem affinity purification (TAP) of dual tagged FoxO3 in HeLa S3 cells followed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) of the elution from the immunoprecipitation. I identified over 1,000 potential FoxO3 binding partners that were not present in the control immunoprecipitation. These candidate binding partners included protein kinases (e.g. mTOR, MAPKs), other tumor suppressors (e.g. p65, p130) and oncogenes (e.g.Myb), as well as proteins that contain a methyl lysine (e.g. WDR17, PHF3) and acetyl lysine (e.g. BAZ2B, BRD1) binding domains. Taken together, these results suggest that FoxO3 functions in large protein complexes that could affect FoxO3 activity. The formation of FoxO3-containing complexes could be triggered by FoxO3 post-translational modifications. By increasing our understanding of the regulation of FoxO3, as well identifying possible interacting proteins, we further our knowledge of the pathways important for both longevity and age related diseases, including cancer.
  • 2010
    Megan Leigh Insco.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Taavi Neklesa.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2000
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • 2006 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2006
  • 2006 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2006
  • pt. A-B, 2004. ScienceDirect
    pt. B ScienceDirect
    edited by David P. Siderovski.
    Also available: Print – pt. A-B, 2004.
  • 2015 Springer
    Maria Cristina Galli, Mercedes Serabian, editors.
    United States Food and Drug Administration Regulation of Gene and Cell Therapies -- The National Institutes of Health Oversight of Human Gene Transfer Research: Enhancing Science and Safety -- Regulatory Oversight of Cell and Gene Therapy Products in Canada -- Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products -- Regulation of Clinical Trials with Advanced Therapy Medicinal Products in Germany -- Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective -- Requirements for Clinical Trials with Gene Therapy and Transplant Products in Switzerland -- Regulatory Frameworks for Gene and Cell Therapies in Japan -- Regulatory Oversight of Gene Therapy and Cell Therapy -- Regulation of Cell and Gene Therapy Medicinal Products in Taiwan -- Regulatory Oversight of Cell- and Tissue-Based Therapeutic Products and Gene Therapy Products in Singapore -- The Regulatory Pathway for Advanced Cell Therapy and Gene Therapy Products in Brazil: A Road to Be Built -- Index.
    Also available: Print – 2015
  • 2014 Springer Protocols
    edited by Gaetano Vitale and Francesca Mion, Department of Medical and Biological Sciences, University of Udine, Udine, Italy.
  • 2010
    Gwen Liu.
    MicroRNA (miRNA) genes, which encode an abundant class of ~22-nucleotide (nt), evolutionarily conserved small RNAs, control a fundamental layer of genetic programs at the post-transcriptional level. However, little is known about how the activity of miRNA genes is regulated and how the regulatory information controlling their activity is encoded. Interestingly, mature miRNAs can often be classified into large families consisting of members with identical seeds (nucleotides 2 through 8 of the mature miRNAs) and highly homologous ~22-nt mature miRNA sequences, but with divergent sequences and structural elements beyond their mature miRNAs. Here we investigated whether members of a miRNA gene family that encode identical or nearly identical mature miRNAs are functionally interchangeable in vivo and if not, why? We compare the activities of the mir-181 gene family in promoting double positive T cell development and show that miRNA genes that encode identical to nearly identical mature miRNAs can have distinct activities. The differences in activity between mir-181a-1 and mir-181c are largely determined by their unique primary/precursor-miRNA (pri/pre-miRNA) loop nucleotides, and the differences in activity between mir-181a-1 and mir-181b-1 are determined by both the pri/pre-miRNA loop and stem. Furthermore, the organization of mir-181a-1/b-1 in a cluster is important for its full activity. We also show that mir-181 family members can differentially regulate target genes quantitatively, and that some target genes can be upregulated. Taken together, we have demonstrated that regulatory information encoded in a miRNA gene beyond the mature miRNA plays a critical role in controlling the activity of the miRNA gene, suggesting that miRNA family members could have evolved different functions through their divergent miRNA gene sequences and structural elements beyond their mature miRNAs. Although, proteins may have evolved to recognize the structural and sequence elements of the pri/pre-miRNAs, we suggest that the regulatory information encoded in the structured pri/pre-miRNA may be directly interpreted through target and pri/pre-miRNA interactions.
  • 2006 ScienceDirect
    Eric H. Davidson.
  • 2007 Springer
    edited by Setsuro Ebashi and Iwao Ohtsuki.
    Also available: Print – 2007
  • 2009 Springer
    Vinagolu K. Rajasekhar, Mohan C. Vemuri, editors.
  • 2015 Springer Protocols
    2014 Springer Protocols
    edited by Gordon G. Carmichael.
    Diverse functions and mechanisms of mammalian long noncoding RNAs -- Sequence-defined oligoaminoamides for the delivery of siRNAs -- A biochemical approach to identify direct microRNA targets -- Native gel analysis for mammalian microRNPs assembled from pre-microRNAs -- Identification and validation of miRNA target sites within nontraditional miRNA targets -- Fractionation of non-polyadenylated and ribosomal-free RNAs from mammalian cells -- Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells -- RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins -- nRIP-seq: A technique to identify RNA targets of an RNA binding protein on a genome-wide scale -- Analysis of the subcellular distribution of RNA by fluorescence in situ hybridization -- RNA fluorescence in situ hybridization in cultured mammalian cells -- Locating RNAs in situ with FISH-STIC probes -- Rapid and efficient elimination of specific nuclear noncoding RNAs in mammalian cells with antisense oligonucleotides -- On using magnesium and potassium ions in RNA experiments -- Studying the affinity, kinetic stability, and specificity of RNA/protein interactions: SINE ncRNA/Pol II complexes as a model system
  • 2011
    Leticia Cristina Britos Cavagnaro.
    Bacteria have evolved robust systems to sense environmental stimuli and limit proliferation under unfavorable conditions. While bacterial defense mechanisms have been characterized, the integration of environmental signals into the regulation of growth and development remains for the most part a mystery. The goal of this work was to identify the mechanisms by which the aquatic bacterium C. crescentus integrates information from the environment into the regulation of growth and development. I studied the transcript and protein changes that occur in C. crescentus in response to nutritional deprivation. The integration of high-throughput transcriptome and proteome analyses allowed me to obtain a comprehensive view of the process. The transcriptome changes were the starting point for the identification of genetic regulatory pathways involved in the response to environmental challenge. The alternative sigma factor SigT, one of the key regulators identified, was shown to activate the expression of a core set of general starvation-stress response genes that are cell cycle regulated during normal development in C. crescentus, and are candidates to mediate the inhibition of growth and division occurring upon environmental challenge. Furthermore, the SigT pathway was shown to directly integrate information from the environment into the circuit that regulates cell cycle progression, through the post-transcriptional regulation of the CtrA master regulator. The molecular analyses were complemented with cell biology studies, which revealed the differential effects of starvation and osmotic stress on chromosome replication and polar morphogenesis in swarmer cells. Overall, this work contributes to the emerging understanding of how the well-characterized regulatory circuit that controls cell cycle progression in C. crescentus integrates environmental signals.
  • 2006 Cold Spring Harb Lab Press
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    meeting organized by Bruce Stillman and David Stewart.
    Mechanism and biology of RNAi -- Genome-wide approaches -- Small RNAs in development -- Telomeres and cancer -- End regulation of transcripts -- RNPs and RNA editing -- Biology of short RNAs -- Control of gene expression by noncoding RNAs -- Heterochromatin -- Quality control, messenger RNA turnover, and translational control.
  • 2012 Springer
    Bibekanand Mallick, Zhumur Ghosh, editors.
    pt. 1. Basics -- pt. 2. Methods -- pt. 3. Applications.
  • 2012 Springer
    Wolfgang R. Hess, Anita Marchfelder.
    This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.
  • 2008 Springer
    Shuiping Jiang, editor.
  • 2005 Springer
    Leonie S. Taams, Arne N. Akbar, Marca H.M. Wauben, editors.
    Also available: Print – 2005
  • 2013 Springer
    Kimberly A. Sackheim, editor.
    "Designed in a concise, easy-to-read style for a wide variety of medical occupations, the Rehab Clinical Pocket Guide is the ideal, handy reference for rehabilitation professionals and other health providers. Divided into four sections that cover inpatient care, clinical strategies, outpatient care, and additional diagnostics and therapeutics, this is the first book of its kind to contain all of the relevant clinical information needed on the rehabilitation unit, including specific admission order sets and topics such as medication dosing, consultant recommendations, specific rehabilitation goals and treatments, and even billing details for various diagnoses. The Rehab Clinical Pocket Guide offers all the clinical material needed to properly treat patients and excel in the field of physical medicine and rehabilitation and will prove an indispensable resource for medical students, residents, physicians, therapists and nutritionists."--P. 4 of cover."
  • 1960-
    Eugene J Taylor, editor.
    Status: Not Checked OutLane Catalog Record
  • 2015 CRCnetBASE
    edited by Richard J. Siegert [and] William M.M. Levack.
    Evidence-based goal setting : the trials and tribulations / Levack, W.M.M. & Siegert, R.S. -- Psychology & goal setting : providing a theoretical foundation / Siegert, R.S., O'Connell, C., & Levack, W.M.M -- Ethics & goal setting : providing a moral foundations / Levack, W.M.M., Pickering, N., Siegert, R.S. -- Goal setting as shared decision-making / Playford, D. -- Meaning as a smarter approach to goals in rehabilitation / McPherson, K.M., Kayes, N.M., Kersten, P. -- Goal attainment scaling in adult neurorehabilitation / Ashford, S., Turner-Stokes, L. -- Goal attainment scaling in paediatric rehabilitation / Steenbeek, D., Gorter J.W., Ketelaar, M., Galama, K., Lindeman, E. -- Applying the international classification of function, disability, and health to goal setting in rehabilitation / Rauch, A., Scheel-Sailer, A. -- An occupation-based, client-centred approach to goal planning and measurement / Doig, E., Fleming, J -- A theoretically based approach to goal setting / Scobbie, L., Dixon, D. -- Goal orientation and goal setting as a topic in German medical rehabilitation research / Meyer, T., Pohontsch, N. -- Goal-setting in social competence treatment after brain injury / Hawley, L.A., Newman, J. -- Goal setting in the context of self-management after stroke / Jones, F. -- Goal-setting and older adults / Parsons, J. -- Goal setting in paediatric rehabilitation / Wiart, L. -- Goals and goal-setting for people with aphasia, their family members, and clinicians / Sherratt, S., Worrall, L., Hersh, D., Howe, T., Davidson, B. -- Goal setting for stroke rehabilitation / Rosewilliams, S.B. -- Current trends and future direction for research and clinical practice / Siegert, R.S., and Levack, W.M.M.
  • 2013 Cambridge
    edited by Robert Iansek, Meg E. Morris.
    Functional neuroanatomy and physiology in movement disorders / Nicola Pavese and David J. Brooks -- Pathophysiology of basal ganglia disorders : neurophysiological investigations / Alfredo Berardelli and Antonio Suppa -- Medical management of movement disorders / Louis C.S. Tan and Kulthida Methawasin -- Functional neurosurgery of movement disorders / Travis S. Tierney and Andres M. Lozano -- Peripheral surgical and movement modification-therapies for movement disorders / Barry Rawicki -- The role of physiotherapy in the rehabilitation of people with movement disorders / Lynn Rochester, Sue Lord, and Meg E. Morris -- The role of occupational therapy in the rehabilitation of people with movement disorders / Ana Aragon, Jill Kings, and Diane Playford -- The role of nursing in the rehabilitation of people with movement disorders / Allison F. Williams, Siok Bee Tan, and Victor McConvey -- The role of neuropsychology in the rehabilitation of people with movement disorders / Georg Dirnberger and Marjan Janahshahi -- The role of the speech pathologist in the rehabilitation of people with movement disorders / Deborah Theodoros -- The role of social work in the rehabilitation of people with movement disorders / Ralph Hampson and Lynette Joubert -- Rehabilitation principles in chronic neurological conditions in adults and children / John Olver .. [et al.] -- Rehabilitation of Parkinson's disease / Robert Iansek and Meg E. Morris -- Rehabilitation of parkinsonian syndromes / David R. Williams -- Rehabilitation of Huntington's disease / Belinda Bilney and Alan Pearce -- Rehabilitation of dystonia / Daniele Volpe and Giovanni Abbruzzese -- Rehabilitation of Friedreich ataxia / Sarah Milne [and others] -- Rehabilitation of cerebral palsy / Pam Thomason and H. Kerr Graham -- Rehabilitation of developmental disorders and motor dysfunction / Nicole Rinehart [and others] -- Selection of clinical outcome measures in rehabilitation of people with movement disorders : theory and practice / Jennifer L. McGinley and Mary Danoudis.
  • 2016 Springer
    A.B. Imhoff [and 4 others], eds.
  • v.1-2=, 2011 ClinicalKey
    [edited by] Terri M. Skirven [and three others].
    Vol. 1. Anantomy and Kinesiology -- Examination -- Skin and Soft Tissue Conditions -- Hand Fractures and Joint Injuries -- Tendon Injuries and Tendinopathies -- Nerve Lacerations -- Compression Neuropathies -- Proximal Nerve Conditions -- Surgical Reconstruction for Nerve Injuries -- Vascular and Lymphatic Disorders -- Stiffness of the Hand -- Vol. 2. Common Wrist Injuries -- Common Elbow Injuries -- Common Shouler Conditions -- Complex Traumatic Conditions -- Arthritis and Related Autoimmune Disorders -- Pain -- Special Techniques of Therapist's Intervention -- Orthotic Intervention: Principles and Techniques -- Other Special Populations -- The Injured Worker -- Evidenced-Based Practice: Integrating Clinical Expertise and Systematic Research.
  • 2010 ScienceDirect
    by Emma K. Stokes.
    Outcome measurement and practice -- International classification of functioning, disability and health (ICF) -- How to choose an outcome measure -- Reliability : error in measurement -- Validity -- Measuring change -- Measuring mobility -- Measuring physical activity -- Measuring fatigue -- Measuring neurological conditions and rehabilitation -- Evaluating satisfaction.
  • 2009
    edited by Christine Arenson ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • pt. A-B., 2006
    edited by Mario C. Raviglione.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Paul Farmer [and others].
    "Bringing together the experience, perspective and expertise of Paul Farmer, Jim Yong Kim, and Arthur Kleinman, Reimagining Global Health provides an original, compelling introduction to the field of global health. Drawn from a Harvard course developed by their student Matthew Basilico, this work provides an accessible and engaging framework for the study of global health. Insisting on an approach that is historically deep and geographically broad, the authors underline the importance of a transdisciplinary approach, and offer a highly readable distillation of several historical and ethnographic perspectives of contemporary global health problems.The case studies presented throughout Reimagining Global Health bring together ethnographic, theoretical, and historical perspectives into a wholly new and exciting investigation of global health. The interdisciplinary approach outlined in this text should prove useful not only in schools of public health, nursing, and medicine, but also in undergraduate and graduate classes in anthropology, sociology, political economy, and history, among others"--Provided by publisher.
  • 2011 Springer
    Carsten Nieder, Johannes A. Langendijk, editors.
  • 2010 Springer
    Luciano L'Abate, Mario Cusinato, Eleonora Maino, Walter Colesso, Claudia Scilletta.
    Relational competence the set of traits that allow people to interact with each other effectively enjoys a long history of being recorded, studied, and analyzed. Accordingly, Relational Competence Theory (RCT) complements theories that treat individuals' personality and functioning individually by placing the individual into full family and social context. The ambitious volume Relational Competence Theory: Research and Mental Health Applications opens out the RCT literature with emphasis on its applicability to interventions, and updates the state of research on RCT, examining what is robust and verifiable both in the lab and the clinic. The authors begin with the conceptual and empirical bases for the theory, and sixteen models demonstrate the range of RCT concerns and their clinical relevance, including: socialization settings for relational competence, the ability to control and regulate the self, relationship styles, intimacy and negotiation, the use of practice exercises in prevention and treatment of pathology, appendices featuring the Relational Answers Questionnaire and other helpful tools. Relational Competence Theory both challenges and confirms much of what we know about the range of human relationships, and is important reading for researchers, scholars, and students in personality and social psychology, psychotherapy, and couple and family counseling.
  • Google Books
    Office of Applied Studies.
    Also available: Print – 1999
  • 2007
    edited by Alexander I. Agoulnik.
    Relaxin and related peptides in male reproduction / Alexander I. Agoulnik -- The vascular actions of relaxin / Arundhathi Jeyabalan ... [et al.] -- The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease / Chrishan S. Samuel, Edna D. Lekgabe, and Ishanee Mookerjee -- Relaxin-like ligand receptor systems: are autocrine/paracrine effectors in tumor cells and modulate cancer: progression and tissue invasiveness / Thomas Klonisch ... [et al.] -- Relaxin family peptide and receptor systems in brain: insights from recent anatomical and functional studies / Sherie Ma and Andrew L. Gundlach. The evolution of the relaxin peptide family and their receptors / Tracey N. Wilkinson and Ross A.D. Bathgate -- Relaxin, the relaxin-like factor and their receptors / Christian Schwabe and Erika E. Büllesbach -- Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone" / Richard Ivell, Kee Heng, and Ravinder Anand-Ivell -- Relaxin physiology in the female reproductive tract during pregnancy / Laura J. Parry and Lenka A. Vodstrcil --
  • 2012 Springer
    A. Ravishankar Rao, Guillermo A. Cecchi, editors.
    Introduction -- Adaptation and contraction theory for the synchronization of complex neural networks -- Temporal coding is not only about cooperation, it is also about competition -- Using non-oscillatory dynamics to disambiguate pattern mixtures -- Functional constraints on network topology via generalized sparse -- Evolution of time in neural networks, from the present to the past, and forward to the future -- Synchronization of coupled pulse-type hardware neuron models for CPG model -- A univesal abstract-time platform for real-time neural networks -- Solving complex control tasks via simple rule(s), using chaotic dynamics in a recurrent neural network model -- Time scale analysis of neuronal ensemble data used to feed neural network models -- Simultaneous EEG-fMRI, integrating spatial and temporal resolution -- Erratum to: Time scale analysis of neuronal ensemble data used to feed neural network models.
  • 2013
    William R. Uttal.
    "Cognitive neuroscientists increasingly claim that brain images generated by new brain imaging technologies reflect, correlate, or represent cognitive processes. In this book, William Uttal warns against these claims, arguing that, despite its utility in anatomic and physiological applications, brain imaging research has not provided consistent evidence for correlation with cognition. Uttal bases his argument on an extensive review of the empirical literature, pointing to variability in data not only among subjects within individual experiments but also in the new meta-analytical approach that pools data from different experiments. This inconsistency of results, he argues, has profound implications for the field, suggesting that cognitive neuroscientists have not yet proven their interpretations of the relation between brain activity captured by macroscopic imaging techniques and cognitive processes; what may have appeared to be correlations may have only been illusions of association. He supports the view that the true correlates are located at a much more microscopic level of analysis: the networks of neurons that make up the brain." -- [Publisher-supplied data]
  • 2008 CRCnetBASE
    B.S. Dhillon.
    Basic mathematical concepts -- Introduction to reliability technology, human error, and quality -- Medical device safety and quality assurance -- Medical device software quality assurance and risk assessment -- Medical device maintenance and sources for obtaining medical device-related failure data -- Human error in health care -- Health care human error reporting systems and models for predicting human reliability and error in health care -- Patient safety -- Introduction to quality in health care -- Quality methods for use in health care.
  • 2011 NAP
    Committee on Advancing Pain Research, Care, and Education, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
    1. Introduction -- 2. Pain as a Public Health Challenge -- 3. Care of People with Pain -- 4. Education Challenges -- 5. Research Challenges -- 6. A Blueprint for Transforming Pain Prevention, Care, Education, and Research -- Glossary -- A. Data Sources and Methods -- B. Summary of Written Public Testimony -- C. The Economic Costs of Pain in the United States -- D. Committee and Staff Biographies.
  • 2014 Springer
    Adina Kalet, Calvin L. Chou, editors.
    Defining and Assessing Competence -- An Example of a Remediation Program -- 'She Needs to Read More': Helping trainees who struggle with medical knowledge -- Remediation of Interpersonal and Communication Skills -- Remediation of Physical Exam Skills -- Assessing and Remediating Clinical Reasoning -- Remediating Lapses in Professionalism -- 'You said, I heard': Speaking the subtext in interracial conversations -- Learning Differences and Medical Education -- 'Well, This Is Awkward': Autism Spectrum Disorder in Medical Trainees -- Stress and Distress and Wellness -- Perspectives from a Psychiatrist in an Office of Advising Resources -- The Metacognitive Competency: The key to life-long learning -- Use of Reflection as a Remediation Tool -- Feedback -- Appreciative Coaching: A positive process for remediation -- Preparing Program Directors to Address Unprofessional Behavior -- The View from the Dean's Office -- Preparing to Conduct Remediation -- 'The Prognosis is Poor': When to give up -- A Research Agenda for the Field of Remediation -- Epilogue: A Student's Perspective on Remediation.
  • 2016 ClinicalKey
    [edited by] Christopher B. Wilson, Victor Nizet, Yvonne A. Maldonado, Jack S. Remington, Jerome O. Klein.
    Also available: Print – 2016
  • 2008
    Deveroux Ferguson.
    Status: Not Checked OutLane Catalog Record
  • 2006
    John Henderson.
    Status: Not Checked OutLane Catalog Record
  • Springer Protocols
    edited by Jack H. Mydlo.
    Renal cell carcinoma / P. Russo -- Pathology of kidney tumors / D.J. Grignon -- Telomerase assay in renal cancer / W.W. Zhang and L.H. Klotz -- Comparative genomic hybridization / J.C. Presti -- Analyzing the FHIT gene by RT-PCR, western blotting, and immunohistochemistry / R. Baffa [and others] -- Detection of apoptosis in renal cell carcinoma / K.J. Pienta and J.F. Williams -- Fluorescence in situ hybridization (FISH) to metaphase and interphase chromosomes / J.A. Macoska -- Polymerase chain reaction detection of DNA sequence deletions / J.A. Macoska -- Matrix metalloproteinases and their inhibitors / A. Kugler, P. Thelen and R.-H. Ringert -- Purification of growth factor mRNA in renal tissues : bFGF-2, FGF-2, TGF [alpha], and EGFR / J.H. Mydlo -- Laser-capture microdissection / G.L. Griewe [and others] -- Expression of c-met and WT-1 / L. Kushner [and others] -- Molecular analysis of the von Hippel-Lindau disease gene / A. Chernoff [and others] -- Experimental models and methods in antibody targeting of renal cell carcinoma / R.L. Vessella [and others] -- Orthotopic model of renal cell carcinoma / D.M. Nanus and D. Engelstein -- Murine animal model / N. Nishisaka [and others] -- Angiogenesis assays / J.H. Mydlo -- Antiangiogenic approaches to renal cell carcinoma / S.C. Campbell, F.K. Reiher and N.D. Smith -- Interferon alpha, GM-CSF-activated T cells, and IL-6 in renal cell carcinoma / B. Patel and A. Belldegrun -- Immunotherapeutic approach to cancer with cutaneous DNA vaccination / W.B. Browne, W.G. Hawkins and J.J. Lewis -- Monoclonal antibodies / E. Oosterwijk -- Treatment strategies in metastatic renal cell carcinoma / P.F. Mulders -- 23assessment of T-cell immune dysfunction in patients with renal cell carcinoma / R.G. Uzzo [and others] -- Transforming growth factor-[beta]1 as a novel marker of response to therapy for renal cell carcinoma / H.L. Adler -- Static and flow cytometry / R. Madeb, D. Pode and O. Nativ.
  • 2013 Springer
    John A. Libertino, editor.
    Epidemiology, Screening, and Clinical Staging / Michael J. Lipsky, Christopher M. Deibert -- Molecular Biology and Genetics / Jeff Klomp, Karl Dykema, Bin Tean Teh, Kyle Furge -- Familial and Hereditary Syndromes / Brian Shuch, Peter Pinto -- Pathology of Renal Cell Carcinoma / Fang-Ming Deng, Jonathan Melamed, Ming Zhou -- Imaging of Renal Cancer / Jalil Afnan, Christoph Wald -- Molecular Imaging for Renal Cell Carcinoma / Jian Q. Yu, Yamin Dou -- History of Renal Surgery for Cancer / Kamal Nagpal, Karim Hamawy -- Natural History, Role of Biopsy, and Active Surveillance of Renal Masses / Anthony T. Corcoran, Marc C. Smaldone, Robert G. Uzzo -- Interventional Radiology and Angioinfarction: Transcatheter Embolization of Renal Tumors / Sebastian Flacke, Shams Iqbal -- Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma / Patrick A. Kenney, Christopher G. Wood -- Rationale for Partial Nephrectomy / Nicholas Donin, William Huang -- Objectifying Complexity of Kidney Cancers: Relationships of Tumor Anatomy and Outcomes / Serge Ginzburg, Alexander Kutikov, Robert G. Uzzo -- Open Partial Nephrectomy / Patrick A. Kenney, Matthew F. Wszolek, John A. Libertino -- Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses / Casey G. Kowalik, David Canes, Ali Moinzadeh -- Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava / Chad Wotkowicz, John A. Libertino -- Role of Lymphadenectomy / Prof. Dr. Hein Van Poppel -- Postoperative Surveillance Protocols for Renal Cell Carcinoma / Megan M. Merrill., Jose A. Karam -- Role of Surgery in Locally Recurrent and Metastatic Renal Cancer / Paul Russo -- Outcomes: Prognostic Factors, Models, and Algorithms / Brandon K. Isariyawongse, Michael W. Kattan -- Adjuvant Systemic Therapy, Immunotherapy, and Targeted Treatment / Linda Cerbone, Cora N. Sternberg -- Role for Radiation Therapy in Renal Cancer / Andrea McKee, Arul Mahadevan, Timothy Walsh -- Surgical Management for Transitional Cell Carcinoma of the Upper Tract / Jason R. Gee -- Management of Non-clear Cell Renal Cell Carcinoma / Henry J. Conter, Jose A. Karam, Nizar M. Tannir.
  • 2008 Springer
    Jean J.M.C.H. de la Rosette, Cora N. Sternberg, and Hein P.A. van Poppel (eds.).
  • 2013 Springer
    Steven C. Campbell, Brian I. Rini, editors.
    Part 1. Localized Disease -- Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors / Frédéric D. Birkhäuser, Nils Kroeger and Allan J. Pantuck -- Pathology of Renal Cell Carcinoma / Ming Zhou and Huiying He -- Familial Renal Cell Carcinoma / Simon P. Kim and Bradley C. Leibovich -- Imaging of Renal Cell Carcinoma / Andrei S. Purysko, Erick M. Remer and Brian R. Herts -- Prognostic Factors for Localized Renal Cell Carcinoma / Brian R. Lane -- Part 2. Management of Localized RCC -- Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass Biopsy / Matthew N. Simmons and Steven C. Campbell -- Radical Nephrectomy for Localized Renal Tumors: Optimum Oncological and Renal Functional Considerations / Paul Russo -- Nephron-Sparing Surgery for Renal Cancer / Alon Z. Weizer, Jeffery S. Montgomery and Khaled S. Hafez -- Thermal Ablation / Surena F. Matin and Kamran Ahrar -- Active Surveillance of the Small Renal Mass / Marc C. Smaldone, Daniel Canter, Alexander Kutikov and Robert G. Uzzo -- Part 3. Locally Advanced Disease -- Locally Advanced Renal Cell Carcinoma / Stephen H. Culp and Christopher G. Wood -- Neoadjuvant Targeted Therapy and Consolidative Surgery / Sean P. Stroup and Ithaar H. Derweesh -- Part 4. Advanced Disease -- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects) / Alexandra Arreola and W. Kimryn Rathmell -- Prognostic Factors in Advanced Renal Cell Carcinoma / Michael M. Vickers and Daniel Y. C. Heng -- Integration of Surgery in Metastatic Renal Cancer / Tom Powles and Axel Bex -- Immunotherapy for Renal Cell Carcinoma / Diwakar Davar, Moon Fenton and Leonard J. Appleman -- Targeted Therapy: Vascular Endothelial Growth Factor / Linda Cerbone and Cora N. Sternberg -- Mammalian Target of Rapamycin in Renal Cell Carcinoma / Eric Jonasch and Michel Choueiri -- Palliative and Supportive Care for Renal Cancer / Armida Parala-Metz and Mellar Davis.
  • 2009 Springer
    Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
    Targeted therapy for metastatic renal call carcinoma: overview -- Molecular genetics in inherited renal cell carcinoma: identification of targets in the hereditary syndromes -- Molecular targets in renal tumors: pathologic assessment -- Interferons and interleukin-2: molecular basis of activity and therapeutic results -- The molecular biology of kidney cancer and its clinical translation into treatment strategies -- VEGF: biologic aspects and clinical approaches -- VEGF and PDGF receptors: biologic relevance and clinical approaches to inhibition -- Sunitinib and axitinib in renal cell carcinoma -- Sorafenib in renal cell carcinoma -- Additional tyrosine kinase inhibitors in renal cell carcinoma -- Integrin [alpha]5[beta]1 as a novel therapeutic target in renal cancer -- Carbonic anhydrase IX: biology and clinical approaches -- Monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma: biological and clinical studies -- Chemokines in renal cell carcinoma: implications for tumor angiogenesis and metastasis -- P13K/Akt/mTOR pathway: a growth and proliferation pathway -- EGFR and HER2: relevance in renal cell carcinoma -- Proteasome-NF[kappa]B signaling pathway: relevance in RCC -- The role of hepatocyte growth factor pathway signaling in renal cell carcinoma -- Smac/DIABLO: a proapoptotic molecular target in renal cell cancer -- EphA2: a novel target in renal cell carcinoma -- Restoring host antitumoral immunity: how coregulatory molecules are changing the approach to the management of renal cell carcinoma -- The role of gangliosides in renal cell carcinoma -- Tumour necrosis factor: misnomer and therapeutic target -- Molecular markers for predicting prognosis of renal cell carcinoma -- Adjuvant therapy for renal cell carcinoma: targeted approaches.
  • 2015 Springer
    Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
  • 2012 Springer
    Robert A. Figlin, W. Kimryn Rathmell, Brian I. Rini, editors.
    Pt. 1. Biology of renal cell carcinoma -- pt. 2. Current and future molecular targets for RCC.
  • 2015 Springer
    Richard R. Heuser, Markus Schlaich, Horst Sievert, editors.
    This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.
  • 2014 ScienceDirect
    edited by Kevin W. Finkel, Scott C. Howard.
    Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.
  • 2008 Springer
    Sara Blakeley (ed.).
    Assessment of Renal Function / Mohan Arkanath -- Imaging of Acute Renal Failure - A Problem-Solving Approach for Intensive Care Unit Physicians / Tom Sutherland -- Drug-Induced Renal Injury / Sara Blakeley -- Acute Kidney Injury / Sara Blakeley -- Medical Management of Acute Renal Failure / Nerina Harley -- Acute Renal Failure in the Surgical Patient / Marlies Ostermann -- Rhabdomyolysis and Compartment Syndrome / Laurie Tomlinson and Stephen Holt -- Multisystem Causes of Acute Renal Failure / Tim Leach -- Therapeutic Plasma Exchange / Tim Leach -- Renal Replacement Therapy / John H. Reeves -- Technical Aspects of Renal Replacement Therapy / Sara Blakeley -- End-Stage Renal Disease / Emile Mohammed -- Clinical Hyperkalemia and Hypokalemia / Harn-Yih Ong -- Clinical Hyponatremia and Hypernatremia / Himangsu Gangopadhyay -- Clinical Metabolic Acidosis and Alkalosis / Sara Blakeley.
  • 2014 Springer
    Tatjana Antic, Jerome B. Taxy.
    Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
  • 2007
    Helmut G. Rennke, Bradley M. Denker.
    Status: Not Checked OutLane Catalog Record
    Review of renal physiology -- Regulation of salt and water balance -- Disorders of water balance : hyponatremia, hypernatremia, and polyuria -- Edematous states and the use of diuretics -- Acid-base physiology and metabolic alkalosis -- Metabolic acidosis -- Disorders of potassium balance -- Urinalysis and approach to the patient with renal disease -- Pathogenesis of major glomerular and vascular diseases -- Progression of chronic renal failure -- Acute renal failure -- Signs and symptoms of chronic renal failure -- Tubulointerstitial diseases.
  • 2014
    Helmut G. Rennke, M.D., professor of pathology, Harvard Medical School and Harvard-MIT Division of Health Sciences and Technology, Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, Bradley M. Denker, M.D., associate professor of medicine, Harvard Medical School, Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, chief of nephrology, Harvard-Vanguard Medical Associates, Boston, Massachusetts.
    Status: Not Checked OutLane Catalog Record
    This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design. New color photomicrographs of clinical conditions. Additional end-of-chapter summaries. Up-to-date information based on new medical findings.
  • 2013 Springer
    Larry K. Golightly, Isaac Teitelbaum, Tyree H. Kiser, Dimitriy A. Levin, Gerard R. Barber, Michael A. Jones, Nancy M. Stolpman, Katherine S. Lundin, editors.
    As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes.This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
  • 2013 ClinicalKey
    Bruce M. Koeppen, Bruce A. Stanton.
    Physiology of body fluids -- Structure and function of the kidneys -- Glomerular filtration and renal blood flow -- Renal transport mechanisms: NaCI and water reabsorption along the nephron -- Regulation of body fluid osmolality: regulation of water balance -- Regulation of extracellular fluid volume and NaCI balance -- Regulation of potassium balance -- Regulation of acid-base balance -- Regulation of calcium and phosphate homeostasis -- Physiology of diuretic action -- App. A: Integrative case studies -- App. B: Normal laboratory values -- App. C: Nephron function -- App. D: Answers to self-study problems -- App. E: Answers to integrative case studies -- App. F: Review examination.
  • 2007
    edited by Bruce M. Koeppen, Bruce A. Stanton.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Kathy Pritchard-Jones, Jeffrey S. Dome, editors.
    This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
  • 2014 Springer
    Lilach O. Lerman, Stephen C. Textor, editors.
    This book describes the recent advances in the understanding of the development and management of renal vascular disease (RVD). Current perspectives regarding the epidemiology of atherosclerotic RVD, its clinical manifestations, and the interaction with injury pathways related to the kidney have evolved considerably, and the widespread introduction of non-invasive methods for identification of RVD using ultrasound, CT, and MR imaging has allowed more facile identification of these diseases than ever before. Renal Vascular Disease provides an accessible, up-to-date summary of the pathophysiology and management of RVD. The clinical paradigms that are emerging in the field, both in regards to RVD and its role in chronic kidney disease (CKD), cardiovascular risk, and the cardiorenal syndromes are discussed in this comprehensive text, making it an essential resource for clinicians and investigators who tackle the challenges of RVD.
  • 2009 Springer
    Walmor C. DeMello, Edward D. Frohlich, editors.
    Systemic versus local renin angiotensin systems: An overview / W.C. DeMello and R.N. Re -- Clinical import of the local renin angiotensin aldosterone systems / E.D. Frohlich -- Renin, prorenin, and the (pro)renin receptor / G. Nguyen and A. Contrepas -- Local renin angiotensin systems in the cardiovascular system / R.N. Re -- Renin-angiotensin-aldosterone system and pathobiology of hypertension / P. Paradis and E.L. Schiffrin -- AT{subscript]1 receptors, angiotensin receptor blockade, and clinical hypertensive disease / R.M. Carey -- Structural and electrophysiological remodeling of the failing heart / W.C. DeMello -- Inhibiting the renin angiotensin aldosterone system in patients with heart failure and myocardial infarction / M.A. Pfeffer -- Left ventricular hypertrophy and treatment with renin angiotensin system inhibition / E.D. Frohlich and J. Díez -- Angiotensin-(1-7), angiotensin-converting enzyme 2, and new components of the renin angiotensin system / A.J. Trask ... [et al.] -- Kinin receptors and ACE inhibitors: An interrelationship / E.G. Erdös, F. Tan and R.A. Skidgel -- Kinins and cardiovascular disease / O.A. Carretero, X.-P. Yang and N.-E. Rhaleb -- CMS and type 2 diabetes mellitus: Bound together by the renin angiotensin aldosterone system / D. Gupta ... [et al.] -- Renin angiotensin aldosterone system and cardiovascular disease / S. Bernard ... [et al.] -- Renin angiotensin system and atherosclerosis / C. Hu and J.L. Mehta -- Renin angiotensin system and aging / L.F. Ferder.
  • 2010 Springer
    Po Sing Leung.
    Overview of the pancreas -- Physiology of the pancreas -- Common pancreatic disease -- Circulating RAS -- Local RAS -- Pancreatic RAS -- Basic techniques for pancreatic research -- Current research of the RAS in diabetes mellitus -- Current research concerning the RAS in pancreatic stem cells -- Current research of the RAS in pancreatitis and pancreatic cancer.
    Also available: Print – 2010
  • 2012 ClinicalKey
    editor, Janet M. Rennie.
    Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods of diagnosis and treatment. This 5th edition represents the state-of-the-art on neonatal care, providing not only detailed pathophysiology and clinical chapters on every condition of the neonate but also comprehensive chapters on the psychosocial aspects of neonatology, such as handling perinatal death and ethical and legal aspects of neonatal care. Contributions from Fetal Medicine experts and Obstetricians provide valuable peripheral information essential to the practice of neonatology. This book is the gold standard for neonatal care and will be an invaluable tool for everyone involved in the care of the neonate. It serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal certification exams, and a useful resource for the entire neonatal care team.
  • Google Books
    Perlmann, Alfred.
    Also available: Print – v. 1, 1914.
  • 2006
    prepared for Agency for Healthcare Research and Quality ; prepared by Abt Associates Inc., Andrea Hassol, Project Director and Co-Investigator, Partners Healthcare System, Richard Zane.
    Provides tools to assist emergency planners in evaluating the feasibility of, and requirements for, reopening shuttered hospitals in their local communities to expand surge capacity during a mass casualty event
  • 2012 Springer
    Scott F.M. Duncan, editor.
    Reoperative Hand Surgery is a major contribution to the literature, offering a wide range of reoperative options for challenging problems that face the reconstructive hand surgeon after failed primary surgery. Concise and discussing all of the more common issues that hand surgeons often face in performing revision surgery, this invaluable title is unique in that it looks specifically at the problem of what to do when the original index procedure did not go as planned. Topics covered include the hand, wrist, forearm and elbow, and several sections of the book discuss some of the psychological and social factors that also go into the decision process to reoperate or not. The chapters are tightly focused so that the important aspects to consider for reoperation can be quickly reviewed. There is also a component that discusses how to avoid other pitfalls and to minimize as well as manage any complications that may occur with reoperative procedures. Importantly, the book is replete with original art work to help describe and demonstrate how to perform many reoperative procedures. The artwork is simple and straightforward but yet detailed enough to convey the important steps and aspects for the surgical intervention it is outlining. Developed by renowned experts in the hand surgery field, Reoperative Hand Surgery is an indispensable, state-of-the-art reference, offering the busy hand and upper extremity surgeon easily accessible information relating to the evaluation, diagnosis, and possible surgical interventions for the diagnoses discussed.
  • 2008 Springer
    edited by Steven Teich, Donna A. Caniano.
  • 2009 Springer
    edited by Richard P. Billingham, Kathleen Kobashi, William Peters.

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