BookKaruna Singh, Neelabh Srivastava, editors.
Summary: Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the readers convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.
Contents:
Part I Human and Animal Mycoses
Pythiosis
Superficial Mycoses in Dogs and Cats
Pathogenic Chrysosporium-related Fungi in Reptiles and Other Animals
Aspergillosis in Humans and Animals
Some Clinically Significant Genera of Dematiaceous Hyphomycetes: An Update
Endemic Mycoses in Americas
Part II Mycotoxins in Relation to Human and Animal Health
Mycotoxins and Their Inhalatory Intake Risk
Tenuazonic acid:A Potent Mycotoxin
Part III Antifungal Therapeutic Candidates
Phytochemicals: New Avenues in Anti-Candidal Activity
Recent Advances in Coumarins as Antifungal Agents.