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  • Book
    Laura Calzà, Luigi Aloe, Luciana Giardino, editors.
    Summary: More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.

    Contents:
    Part I. Basic Science
    Nerve Growth Factor, The First Molecule of the Neurotrophin Family
    The First and Last Time I Met Rita Levi-Montalcini: From the Insect Neurotrophic Factor to the Nerve Growth Factor Clinical Application
    NGF Signalling in Endosomes
    The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery
    Part II. Development and Regeneration
    NGF and Endogenous Regeneration: From Embryology Toward Therapies
    The Versatile Roles of Nerve Growth Factor in Neuronal Attraction, Odontoblast Differentiation and Mineral Deposition in Human Teeth
    An Overview of Adult Neurogenesis
    Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis
    Part III. Alzheimer and Central Nervous System
    Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology
    NGF and Amyloid Precursor Protein in Alzheimer’s Disease: From Molecular Players to Neuronal Circuits
    A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer´s Disease
    NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimers Disease?
    Part IV. Complex Behaviors
    When Nerve Growth Factor Met Behavior
    Crosstalk of BDNF and GDNF in Spinal Substantia Gelatinosa (Lamina II): Focus on Circuitry
    PART V. Clinical Medicine
    BDNF Gene as a Precision Skill of Obesity Management
    The Science of Love: State of the Art
    NGF and Retinitis Pigmentosa: Structural and Molecular Studies
    NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders
    Part VI. Veterinary Medicine
    Nerve Growth Factor (NGF) and Animal Reproduction
    Neurotrophins in the Brain of Teleost Fish: The State of the Art.
    Digital Access Springer 2021