BookJuichi Ito, editor.
Summary: The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
Contents:
Part I. Targets of Regenerative Medicine for the Inner Ear
1. Anatomy of the Inner Ear
2. Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear
3. Hair cell
4. Stereocilia
5. Cochlear Lateral Wall
6. Spiral Ganglion Cell and Auditory Neuron
7. Synaptic Contacts between Hair Cells and Primary Neurons
8. Otolith
9. Tectorial membrane
Part II. Development of the Inner Ear
10. Development and regeneration
11. Otic Induction
12. Cochlear Development
13. Vestibular Development
Part III. Cochlear Implants
14. Cochlear Implant: Past, Present and Future
15. Recent Progress in Cochlear Implant
16. Regenerative medicine in cochlear implantation
17. Artificial cochlear epithelium
18. Auditory Brainstem Implant
Part IV. Hair Cell Regeneration
19. Hair Cell Regeneration in the Avian
20. Self Repair
21. Transdifferentiation
22. Dedifferentiation-mediated Regeneration
23. Gene Therapy
24. Cell Therapy
Part V. Spiral Ganglion Neuron Regeneration
25. Clinical Background
26. SGN development
27. Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons
28. Cell therapy
29. Afferent dendrite and axon
Part VI. Stem Cells
30. Inner ear stem cells
31. Pluripotent Stem Cells
32. Somatic Stem Cells
Part VII. Future Perspective
33. Regenerative Medicine for the Inner Ear
Summary.