BookGrant Cooper, Joseph Herrera, Jason Kirkbride, Zachary Perlman, editors.
Summary: Regenerative medicine (RM) is a rapidly expanding topic within orthopedic and spine surgery, sports medicine and rehabilitation medicine. In the last ten years, regenerative medicine has emerged from the fringes as a complement and challenge to evidence-based medicine. Both clinicians and patients alike are eager to be able to offer and receive treatments that don't just surgically replace or clean old joints or inject away inflammation or work as a stop-gap measure. Regenerative medicine encompasses everything from the use of stem cells and platelet-rich plasma (PRP) to prolotherapy, viscosupplementation and beyond. This book will provide healthcare practitioners dealing with spine and joint pain with the most current, up-to-date evidence-based information about which treatments work, which treatments don't, and which are on the horizon as potential game changers. Chapters are arranged in a consistent format and cover the spine, shoulder, elbow, hand and wrist, hip, knee, and foot and ankle, providing a thorough, top-to-bottom approach. A concluding chapter discusses current and future directions and applications of RM over the next decade or two. Timely and forward-thinking, Regenerative Medicine for Spine and Joint Pain will be a concise and practical resource for orthopedists, spine surgeons, sports medicine specialists, physical therapists and rehabilitation specialists, and primary care providers looking to expand their practice.
Contents:
Intro
Contents
Contributors
Chapter 1: Introduction to Regenerative Medicine
Regenerative Medicine Intro Combined
References
Chapter 2: Basic Science Concepts in Musculoskeletal Regenerative Medicine
Introduction
Musculoskeletal Development
Early Musculoskeletal Embryogenesis
Bone Embryogenesis
Synovial Joint Development
Spine Joint Development
Tendon and Ligament Development
Musculoskeletal Tissue Homeostasis and Response to Injury
Osteoarthritis of Articular Cartilage
Intervertebral Disc Degeneration
Tendon and Ligament Degeneration Conclusion
References
Chapter 3: Viscosupplementation
Introduction
History
Biology
Indications
Procedure
Efficacy
Treatment Algorithms
Safety
Comparison to Alternative Treatments
Glucosamine and Chondroitin
Market
References
Chapter 4: Stem Cells
Introduction
History
Bone Marrow-Derived Stem Cells
Adipose-Derived Stem Cells
Amniotic Tissue-Derived Products
Adverse Events Associated with Stem Cell Therapy
Conclusion
References
Chapter 5: Platelet-Rich Plasma
Introduction
Basic Science of PRP and Mechanism of Action Creation and Classification of PRP
Clinical Applications of PRP
Tendinopathy
Osteoarthritis
Ligament and Meniscus Injuries
Muscle Injuries
Spine Disorders
Advantages of PRP
Disadvantages of PRP
Regulation of PRP
Future Directions
References
Chapter 6: Prolotherapy
Introduction
Mechanism of Action
Effects of Prolotherapy on Ligaments and Tendons In Vitro and in Animal Studies
Osteoarthritis Clinical Studies
Prolotherapy Effects on Small Joints
Prolotherapy Effects on Knee Osteoarthritis Intra-articular Prolotherapy Treatment Versus Corticosteroid and Platelet-Rich Plasma Treatments
Intra-articular Versus Extra-articular Injections for Joint Pain
Sacroiliac Joint and Axial Spine Prolotherapy Treatments
Tendinopathy Clinical Studies
Lateral Epicondylitis
Achilles Tendinopathy
Rotator Cuff Tendinopathy
Side Effects and Adverse Events
References
Chapter 7: Regenerative Medicine for the Spine
Introduction
Epidemiology
Anatomy
Overview of Back Pain Pathology and Treatment
Pain Generators of the Spine
Intervertebral Disc Pain Radiculopathy
Zygapophyseal Joint (Facet) Arthropathy
Sacroiliac Joint Dysfunction
Back Musculature Atrophy
Back Ligament Dysfunction
Overall Levels of Evidence
Limitations of Current Studies and Future Implications
Regulation Concerns
Future Directions
Conclusion
References
Chapter 8: Regenerative Medicine for the Shoulder
Tendinopathy in the Shoulder: The Rotator Cuff and Proximal Biceps Tendon
Rotator Cuff Tendinopathy
Rotator Cuff Tears
Biceps Tendinopathy
Tendinopathy in the Shoulder: Regenerative Medicine Applications