All Stanford University & Hospital ID holders are now welcome to visit Lane Library! Learn More
Today's Hours: 8:00am - 8:00pm
Filters applied
Did You Mean?
  • Book
    edited by Anders Björklund, M. Angela Cenci.
    Intro -- Recent Advances in Parkinson's Disease -- Copyright -- Contributors -- Contents -- Preface: The evolving scenario of Parkinson's research -- Part I: Basic Science -- Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease -- 1. Introduction -- 2. Establishment of iPSC technology and methods of differentiation into DAns -- 2.1. Establishment of induced pluripotent stem cells -- 2.2. Differentiation into DAns -- 3. iPSC-derived neurons for disease modeling -- 3.1. Endoplasmic reticulum stress -- 3.2. Protein trafficking and degradation deficits 3.3. Mitochondrial defects and oxidative stress -- 3.4. Alterations in calcium homeostasis -- 4. iPSC-derived glial cells for disease modeling -- 5. Co-culture systems, 3D cultures and organoids for disease modeling -- 6. iPSC-derived neurons for cell-based treatments -- 7. Limitations of iPSC-based models -- 8. Future applications -- 9. Conclusions -- Acknowledgments -- References -- Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal -- 1. Introduction -- 2. Models in different species -- 3. The importance of nigrostriatal dopaminergic degeneration 4.3. Tertiary and quaternary structure of aSyn -- 4.4. The effect of PD-associated mutations in aSyn -- 4.5. Post-translational modifications -- 5. Alpha-synuclein pathology in the synapse -- 6. aSyn pathology in mitochondria -- 7. aSyn pathology in the ER-Golgi compartments -- 7.1. Degradation and clearance of aSyn -- 7.2. aSyn pathology and the cytoskeleton -- 7.3. Effects of aSyn in the nucleus -- 8. Spreading of aSyn pathology -- 9. The interplay between aSyn and the microbiome -- 10. Inflammation -- 11. Conclusions and outlook -- Acknowledgments -- References
    Digital Access  ScienceDirect 2020