Books
- Haben : the Deafblind Woman Who Conquered Harvard Law — Handbook of Quality of Life in Cancer (237)
- Handbook of Recidivism Risk/needs Assessment Tools — Hearing Loss-- Causes, Prevention, and Treatment (237)
- Heart-- a History. First edition. — HIV/AIDS Surveillance Technical Report (237)
- HIV and Aging — Hysteroscopy Simplified by Masters (237)
- PrintSandeep Jauhar.Summary: "For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was the spark of life as well as somehow the driver of emotion and the seat of the soul. As the cardiologist and bestselling author Sandeep Jauhar shows in [this book], it was only recently that we demolished age-old taboos and developed the science to change the way we live. Deftly weaving together his own experiences with the defining discoveries of the past, Jauhar tells the colorful and little-known story of the doctors who risked their careers and the patients who risked their lives to know and heal this most vital organ."--Jacket.
Contents:
Prologue : CT scan
Introduction : the engine of life
Part I. Metaphor. A small heart
Prime mover
Part II. Machine. Clutch
Dynamo
Pump
Nut
Stress fractures
Pipes
Wires
Generator
Replacement parts
Part III. Mystery. Vulnerable heart
A mother's heart
Compensatory pause. - DigitalBranko Furst.Summary: What drives the circulation? In this comprehensive review of existing circulation models, the conventional view that the heart is a pressure-propulsion pump is challenged. The existing models fail to explain an increasing number of observed circulatory phenomena. A unifying circulation model is proposed in which the blood, responding to metabolic demands of the tissues, is the primary regulator of cardiac output. This new model arises from accumulated clinical and experimental evidence. The heart, rather than being an organ of blood propulsion, assumes a secondary role and generates pressure by impeding the flow of blood. This is supported by examples from the fields of early embryonic circulation, comparative phylogeny, functional morphology, exercise physiology and a range of clinical scenarios. The Heart and Circulation: An Integrative Model offers a paradigm shift in the understanding of circulatory phenomena. It will become a valuable resource for all those clinicians, researchers, educators and students who, having been confronted with the paradox of the circulation, are looking for a broader interpretation.
Contents:
PART I. Early Embryo Circulation
The Onset of Circulation
Hemodynamics of the Early Embryo Circulation
Flow Patterns in the Early Embryo Circulation
Is There a Circulation Without a Heart?
Embryo Heart is not a Peristaltic Pump
Flow Perturbation Experiments
Heart Rate Perturbations
The Heart as Generator of Pressure
Ventriculo-Vascular Interaction
A Brief Comparative Phylogeny
Evolutionary Aspect of the Rhythmical System
PART II. Mature Circulation
Functional Morphology of the Heart
Regulation of Cardiac Output
Circulatory and respiratory functions of the blood
Models of the Heart
Cardiovascular Response during Exercise
Hemodynamic Effects of Aortic Occlusion
Increased Pulmonary Flows
Single Ventricle Physiology
Blood as an Organ. - DigitalBranko Furst.Summary: This extensively revised second edition traces the development of the basic concepts in cardiovascular physiology in light of the accumulated experimental and clinical evidence. It considers the early embryonic circulation, where blood circulation suggests the existence of a motive force, tightly coupled to the metabolic demands of the tissues. It proposes that rather than being an organ of propulsion, the heart, serves as an organ of control, generating pressure by rhythmically impeding blood flow. New and expanded chapters cover the arterial pulse, circulation in the upright posture, microcirculation and functional heart morphology. Heart and Circulation offers a new perspective for deeper understanding of the human cardiovascular system. It is therefore a thought-provoking resource for cardiologists, cardiac surgeons and trainees interested in models of human circulation.
Contents:
Intro; Foreword I; Foreword II; Foreword III; Foreword I to the German Edition; Foreword II to the German Edition; Preface; Acknowledgments; Contents; Abbreviations; Introduction to the First Edition; Introduction to the Second Edition; Part I: Embryonic Circulation;
1: Early Embryo Circulation; 1.1 Introduction; 1.2 Morphologic Features; References;
2: The Onset of Circulation; 2.1 Chick Embryo; 2.2 Mouse Embryo; 2.3 Zebrafish Embryo; References;
3: Hemodynamics of the Early Embryo Circulation; 3.1 Chick Embryo; 3.2 Zebrafish Embryo; 3.3 Mammalian Embryo; References
4: Flow Patterns in the Early Embryo Circulation4.1 Heart Vortex Formation; References;
5: Is There a Circulation Without a Heart?; 5.1 Heart Ablation Studies; 5.2 Cardiac Mutants; References;
6: The Embryo Heart is Not a Peristaltic Pump; References;
7: Flow Perturbation Experiments; References;
8: Heart Rate Perturbations; References;
9: The Heart as a Generator of Pressure; References;
10: Ventriculo-Vascular Interaction; References;
11: A Brief Comparative Phylogeny; 11.1 Invertebrates; 11.2 Tracheate Insects; 11.3 Early Vertebrates; 11.4 Vertebrates 11.4.1 The Origin of Lymphatic Circulation11.4.2 Fish; 11.4.3 Amphibians; 11.4.4 Mammals and Birds; References;
12: Evolutionary Aspect of the Rhythmical System; References; Part II: Mature Circulation;
13: Functional Morphology of the Heart; 13.1 Historical Perspective; 13.2 Models of Ventricular Structure and Function; 13.2.1 Ventricular Myocardial Band; 13.2.2 The Opposing Force Model; 13.3 Intracardiac Blood Flow Patterns; 13.4 A Flow-Restraining Function; References;
14: Regulation of Cardiac Output; 14.1 Left Ventricular View of the Circulation; 14.1.1 Heart Failure Therapy 14.2 Regulation of Cardiac Output by the Periphery14.3 Guyton's Venous Return Model; 14.4 Critique of the Venous Return Model; References;
15: Circulatory and Respiratory Functions of the Blood; 15.1 Phenomenon of Vestigial Circulation; 15.2 Negative Interstitial Pressure; 15.3 The Significance of Artificial Respiration: A Historical Overview; References;
16: Models of the Heart; 16.1 Early Isolated Heart Preparations and the "Law of the Heart"; 16.2 An Obscure Model (Hydraulic Ram); 16.3 Quantification of Ventricular Pump; 16.4 Ventricular Elastance Model 16.5 Energetic Aspect of Myocardial Contraction16.6 Length-Dependent Activation of Cardiac Muscle; 16.7 Ventricular Assist Devices and Total Artificial Heart; References;
17: Cardiovascular Response During Exercise; 17.1 The Role of Peripheral Circulation; 17.1.1 Metabolic Control of Muscle Blood Flow; 17.1.2 Skeletal Muscle Pump Hypothesis; 17.2 The Heart in Exercise; 17.3 Changes in Pulmonary Circulation; 17.4 "The Sleeping Giant"; References;
18: Hemodynamic Effects of Aortic Occlusion; 18.1 Systemic Circulation; 18.2 Cardiac Effect of Aortic Occlusion; 18.3 Metabolic Changes During Aortic OcclusionDigital Access Springer 2020 - DigitalMeenakshisundaram Ramachandran, editor ; P. Thirumalaikolundusubramanian, assistant editor.Contents:
Epidemiology of cardiovascular toxins / Churchill Lukwiya Onen
Cellular and molecular perspectives on cardiac toxins / Reza Tabrizchi
Environmental toxins and the heart / Sahand Rahnama-Moghadam, L. David Hillis, and Richard A. Lange
Problems and paradoxes of animal toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian
Plant toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian
Native medicines and cardiovascular toxicity / Ashish Bhalla, [et al.]
Cardiovascular toxicity from marine envenomation / Benjamin Seymour, Athena Andreosso, and Jamie Seymour
Cardiovascular toxicity of cardiovascular drugs / Ramachandran Meenakshisundaram, [et al.]
Cardiovascular toxicity as a result of psychotropic drugs / Mythily Subramaniam, [et al.]
Cardiovascular toxicity of noncardiovascular drugs / Omi Bajracharya, P. Ravi Shankar, and Nisha Jha
Cardiovascular toxicity from chemotherapy and anticancer treatment / Angela Esposito, [et al.]
Association of human immunodeficiency virus infection with exposure to highly active antiretroviral therapy and its adverse cardiovascular effects / Steven E. Lipschultz, [et al.]
Toxic effects of alcohol on the heart / Subroto Acharjee, Bhaskar Purushottam, and Vincent M. Figueredo
The effects of active and passive smoking and cardiovascular disease / Mahmood Ahmad, Emmanuel Selvaraj, and Ramachandran Meenakshisundaram
Cardiovascular toxicity as a result of recreational drugs / Rohin Francis and Azad Ghuran
Pediatric cardiovascular toxicity : special considerations / Jennifer A. Lowry
Cardiovascular toxicity as a result of radiological imaging / Shah Sweni, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian
Nanomaterials and cardiovascular toxicity / Arghya Paul, [et al.]
Forensic pathology related to cardiovascular toxicity / Magdy A. Kharoshah, [et al.]
Ethics, legality, and education in the practice of cardiology / Ponniah Thirumalakolundusubramanian, Ramachandran Meenakshisundaram, and Subramanian Senthilkumaran.Digital Access ScienceDirect 2015 - DigitalDavid S. Feldman, Paul Mohacsi, editors.Summary: This textbook offers an up-to-date, user-friendly guide on the evaluation, diagnosis and treatment of heart failure. Each chapter is dedicated to providing comprehensive coverage of every aspect of heart failure from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventative cardiology. Heart Failure provides the trainee and practising cardiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients with a valuable resource featuring extensive guidance on the diagnosis and management of a range of conditions related to heart failure.
Contents:
Epidemiology of Heart Failure.- Pathophysiology of Heart Failure.- Evaluation of HF.- Management of Hospitalized Patients.- Management of Heart Failure Part One.- Management of Heart Failure Part Two.- Management of Heart Failure Part Three Pharmacotherapy.- Comorbidities and Coexisting Conditions With HF.- Cardiac Surgery in HF.- Heart Transplantation Part I.- Heart Transplantation Part II.- Heart Transplantation Part I.- Pulmonary Hypertension.- Mechanical Circulatory Support Part I.- Mechanical Circulatory Support Part II; Management of Devices After Implantation.- Mechanical Circulatory Support Part III.- Mechanical Circulatory Support Part IV, Complications.Digital Access Springer 2019 - Digital[edited by] G. Michael Felker, Douglas L. Mann.Contents:
Molecular basis of heart failure
Cellular basis for heart failure
Cellular basis for myocardial regeneration and repair
Myocardial basis for heart failure : role of cardiac interstitium
Molecular signaling mechanisms of the renin-angiotensin system in heart failure
Adrenergic receptor signaling in heart failure
Role of innate immunity in heart failure
Oxidative stress in heart failure
Natriuretic peptides in heart failure: pathophysiologic and therapeutic implications
Systolic dysfunction in heart failure
Alterations in ventricular function : diastolic heart failure
Alterations in ventricular structure : role of left ventricular remodeling and reverse remodeling in heart failure
Alterations in the sympathetic and parasympathetic nervous systems in heart failure
Alterations in the peripheral circulation in heart failure
Alterations in kidney function associated with heart failure
Alterations in skeletal muscle in heart failure
Alterations in cardiac metabolism in heart failure
Epidemiology of heart failure
Heart failure as a consequence of ischemic heart disease
Heart failure as a consequence of dilated cardiomyopathy
Restrictive and infiltrative cardiomyopathies and arrhythmogenic right ventricular dysplasia/cardiomyopathy
Cardiac amyloidosis
Heart failure as a consequence of hypertrophic cardiomyopathy
Heart failure as a consequence of genetic cardiomyopathy
Heart failure as a consequence of hypertension
Heart failure as a consequence of valvular heart disease
Heart failure as a consequence of congenital heart disease
Heart failure as a consequence of viral and nonviral myocarditis
Heart failure in the developing world
Heart failure and human immunodeficiency virus
Clinical evaluation of heart failure
Cardiac imaging in heart failure
Biomarkers and precision medicine in heart failure
Hemodynamics in heart failure
Disease prevention in heart failure
Acute heart failure
Contemporary medical therapy for heart failure patients with reduced ejection fraction
Management of arrhythmias and device therapy in heart failure
Treatment of heart failure with preserved ejection fraction
Management of heart failure in special populations : older patients, women, and racial/ethnic minority groups
Stem cell-based and gene therapies in heart failure
Neuromodulation in heart failure
Pulmonary hypertension
Heart transplantation
Circulatory assist devices in heart failure
Cardio-oncology and heart failure
Disease management and telemedicine in heart failure
Management of comorbidities in heart failure
Quality and outcomes in heart failure
Decision making and palliative care in advanced heart failureDigital Access ClinicalKey 2020 - DigitalHoward Eisen, editor.Summary: This book offers comprehensive information on all aspects of heart failure. Coverage includes information on the pathophysiology of heart failure, the clinical evaluation of patients with heart failure, and device therapy such as pacemakers and defibrillators.
Contents:
Molecular Changes in Heart Failure
Hemodynamics and Heart Failure
Imaging and Heart Failure
Acute and Chronic Right Ventricular Failure
Inhibition of the Renin-Angiotensin-Aldosterone System
Inhibition of the Sympathetic Nervous System
Management of the Patient with Heart Failure with Preserved Ejection Fraction
Acute Decompensated Heart Failure: Classification, Epidemiology and Pathophysiology
Acute Decompensated Heart Failure: Presentation, Physical Exam, and Laboratory Evaluation
Acute Decompensated Heart Failure?Treatment Guidelines
Acute Decompensated Heart Failure: Treatment? Specific Therapies
Acute Decompensated Heart Failure? Treatment with Guideline Determined Medical Therapy and Discharge Planning
Cardiac-Oncology: Management of the Patient with Heart Failure after Chemotherapy
Atrial Arrhythmias and Heart Failure
Ventricular Arrhythmias and Heart Failure
Cardiac Defibrillators and Heart Failure
Cardiac Resynchronization Therapy in Heart Failure
Revascularization and Heart Failure
Valve Repair and Replacement in Congestive Heart Failure Patient Selection for Cardiac Transplantation
Pathophysiology of the Alloimmune Response and Immunosuppression
Antibody-Mediated Rejection
Infections After Cardiac Transplantation
Post-Transplant Complications?Hypertension, Renal Dysfunction, Diabetes Mellitus, Malignancy, Arrhythmias, Osteoporosis, Sexual Dysfunction
Patient Selection
Acute Mechanical Circulatory Support
Mechanical Circulatory Support as a Bridge to Heart Transplantation
Medical Management of the Patient with Chronic Mechanical Circulatory Support
The Total Artificial Heart
Physiology of Stem Cells
Stem Cell Therapy in Heart Failure
Origins of Quality Metrics
Exercise and Patients with Heart Failure
Heart Failure Management and Development of Heart Failure Programs
Inflammation and Heart Failure. - DigitalLongjian Liu.Contents:
Introduction
Pathophysiology and risk profiles of heart failure
Research and design
Biostatistical basis of inference in heart failure study
Advanced biostatistics and epidemiology applied in heart failure study
Precision medicine and areas for further research.Digital Access ScienceDirect 2018 - DigitalMd. Shahidul Islam, editor.Summary: "Heart Failure: From Research to Clinical Practice” contains chapters that describe the current views on the biological mechanisms, clinical assessment, diagnosis and evidence-based treatments of the condition. Topics in this volume range from basic research at cell and molecular level to patient care in everyday clinical practice and provide essential background information and analyses of recent advances for a deeper understanding of the issues involved. With contributions from international experts in their specified fields and are suitable for both beginners and more advanced readers. This volume includes not only the essential information for clinical practice but also the latest information from the contemporary guidelines and the recommendations from leading societies. It also covers ongoing research and puts forward new hypotheses that can be tested in future research. This comprehensive volume will provide a valuable resource for both research students and expert clinicians"--Publisher's description.
Contents:
Heart failure: from research to clinical practice / Md. Shahidul Islam
Transition of left ventricular ejection fraction in heart failure / Yasuhiko Sakata, Kanako Tsuji, Kotaro Nochioka, Hiroaki Shimokawa
Combination therapy of renin angiotensin system inhibitors and [beta]-blockers in patients with heart failure / Kotaro Nochioka, Yasuhiko Sakata, Hiroaki Shimokawa
Combination of hydralazine and isosorbide-dinitrate in the treatment of patients with heart failure with reduced ejection fraction / Noémi Nyolczas, Miklós Dékány, Balázs Muk, Barna Szabó
The art and science of using diuretics in the treatment of heart failure in diverse clinical settings / Md. Shahidul Islam
Treatment of heart failure with preserved ejection fraction / Adriana Mihaela Ilieșiu, Andreea Simona Hodorogea
Circulating biomarkers in heart failure / Alexander E. Berezin
Evolving role of natriuretic peptides from diagnostic tool to therapeutic modality / Ines Pagel-Langenickel
The role of cardiologists in the management of patients with heart failure / Vera Maria Avaldi, Jacopo Lenzi
Optimizing management of heart failure by using echo and natriuretic peptides in the outpatient unit / Frank Lloyd Dini, Gani Bajraktari, Cornelia Zara, Nicola Mumoli, Gian Marco Rosa
Physical training and cardiac rehabilitation in heart failure patients / Cesare de Gregorio
Advanced non-invasive imaging techniques in chronic heart failure and cardiomyopathies / Gianluca Di Bella, Fausto Pizzino, Rocco Donato, Dalia Di Nunzio, Cesare de Gregorio
Pathogenesis, clinical features and treatment of diabetic cardiomyopathy / Núria Alonso, Pedro Moliner, Dídac Mauricio
Heart failure and kidney disease / Dario Grande, Margherita Ilaria Gioia, Paola Terlizzese, Massimo Iacoviello
Dysthyroidism and chronic heart failure: pathophysiological mechanisms and therapeutic approaches / Caterina Rizzo, Margherita Ilaria Gioia, Giuseppe Parisi, Vincenzo Triggiani, Massimo Iacoviello
Management of bradyarrhythmias in heart failure: a tailored approach / Daniele Masarone [and others]
Percutaneous mitral valve interventions and heart failure / Abhishek Sharma, Sunny Goel, Sahil Agrawal
Left ventricular assist devices: a state of the art review / Christina Feldmann, Anamika Chatterjee, Axel Haverich, Jan D. Schmitto
Palliative care in the management of patients with advanced heart failure / Susan E. Lowey
Athlete's heart and left heart disease / Cesare de Gregorio, Dalia Di Nunzio, Gianluca Di Bella
Central sleep apnea with Cheyne-Stokes breathing in heart failure:from research to clinical practice and beyond / K. Terziyski, A. Draganova
The evolution of mhealth solutions for heart failure management / Evanthia E. Tripoliti, Georgia S. Karanasiou, Fanis G. Kalatzis, Katerina K. Naka, Dimitrios I. Fotiadis
New insights in cardiac calcium handling and excitation-contraction coupling / Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli
Critical appraisal of multivariable prognostic scores in heart failure: development, validation and clinical utility / Andrea Passantino, Pietro Guida, Giuseppe Parisi, Massimo Iacoviello, Domenico Scrutinio
Erratum to: Management of bradyarrhythmias in heart failure: a tailored approach / Daniele Masarone [and others]
Erratum to: Percutaneous mitral valve interventions and heart failure / Abhishek Sharma, Sunny Goel, Sahil Agrawal.Digital Access Springer 2018 - DigitalLorna Swan, Alexandra A. Frogoudaki, editors.Summary: This book sheds new light on the diagnosis and treatment of Heart Failure in adult patients with congenital heart disease. This is a rapidly growing clinical issue for this group of patients and the clinical teams caring for them. The book highlights the major clinical dilemmas in diagnosing heart failure in patients with a lifelong cardiac condition and describes in details the utility of biomarkers, complex imaging and functional tests, e.g. the cardiopulmonary exercise testing. A step-wise approach to treatment is described from drug therapy through to devices and transplantation. As such, the book offers an essential guide for cardiologists and cardiac surgeons looking to optimize the management of patients with delicate physiology and complex disease.
- DigitalEdoardo Gronda, Emilio Vanoli, Alexandru Costea, editors.
- Digitaledited by Udi Nussinovitch.Contents:
Pathphysiology of autoimmunity and immune-mediated mechanisms in cardiovascular diseases / O. Shamriz, U. Nussinovitch and N.R. Rose
Organ-specific autoimmune myocardial diseases / A.L.P. Caforio, R. Marcolongo, G. Malipiero, C. Agostini, M. Seguso, N. Gallo, M. Plebani and S. Iliceto
Autoantibodies directed against G-protein-coupled receptors in cardiovascular diseases / B. Bornholz, G. Wallukat, D. Roggenbuck and I. Schimke
Immune-mediated accelerated atherosclerosis / S. Grubber, D. Tsiantoulas and C.J. Binder
A study of cardiac function, atherosclerosis, and arrhythmogenicity / U. Nussinovitch, A. Sadoo and M. Malik
Rheumatiod arthritis / T. Dimitroulas, A. Sandoo, S. Skeoch, M. O'Sullivan, M. Yessirkepov, L. Ayvazyan, A.Y. Gasparyan, G. Metsios and G.D. Kitas
Juvenile idiopathic arthritis / A. Ravelli, B. Schiappaietra, S. Verazza and A. Martini
Spondyloarthritides / J. Braun, S.C. Helsinga, H.J. Trappe and M.T. Nurmohamed
Polymyalgia rheumatica / E. Bartolomi, G. Pucci, A. Alunno, R. Gerli and G. Schillaci
Systemic lupus erythematosus / K. Tselios and M.B. Urowitz
Neonatal lupus / C. Miliaresis, C. Phoon, J. Buyon and D. Friedman
Sjögren's syndrome / S. Fragkioudaki, H.M. Moutspoulos and C.P. Mavragani
Systemic sclerosis / A. Vacca
Dermatomyositis and polymyositis / L.P. Diederichsen, H. Sanner, I. Sjaastad, and I. E. Lundberg
Gout / C. Van Durme and R. Landewé
Giant cell arteritis / M.J. Koster, E.L. Matteson and K.J. Warrington
Takayasu's arteritis / H. Zhang, L. Yang and X. Jiang
Polyarteritis nodosa / L. Guillevin
Kawasaki disease / C. Reuter, L. Mithal and S. Shulman
ANCA-associated vasculitis / M.R. Hazebroek, P. Van Paassen, R. Dennert and S. Heymans
Behçet's disease / A. Soriano, N. Pipitone and C. Salvarani
Rheumatic fever and rheumatic heart disease / L. Guilherme, R.O. Sampaio, S. Freschi De Barros, K.F. Köhler, G.S. Spina, F. Tarasoutchi and J. Kalil
Chagas cardiomyopathy / F. Fernandes, C.H. Valente Moreira, J.M. Barbosa-Ferreira and E.C. Sabino
Familial mediterranean fever / U. Nussinovitch and A. Livneh
Desirable and adverse effects of antiinflammatory agents on the heart / M. Imazio, S. Maestroni, A. Valenti, V. Ramoni and A. Brucato
The effects of immunosuppresive and cytoxic drugs on the heart / S.D. Russell
Autoantibody-directed therapy in cardiovascular diseases / J. Müller, G. Wallukat and I. Schmike
Cardiac immunomodulation / S. Könemann, M. Dörr and S.B. Felix.Digital Access ScienceDirect 2017 - Digitaledited by Fabiola Atzeni, Andrea Doria, Michael Nurmohamed, Paolo Pauletto.Contents:
Cellular immunity: a role for cytokines
Organ-specific autoimmunity involvement in cardiovascular disease
Neonatal lupus syndromes: pathogenesis and clinical features
Subclinical cardiovascular damage in systemic rheumatic diseases
Atherosclerosis and autoimmunity
Inflammasomes and inflammatory cytokines in early atherosclerosis
Treatment of lipid metabolism disturbances in autoimmune diseases
Cardiac imaging techniques in systemic autoimmune diseases
New cardiac imaging tools and invasive techniques in systemic autoimmune diseases (Part II)
Cardiac diseases in rheumatoid arthritis
Cardiac involvement in systemic lupus erythematosus
Cardiac involvement in the antiphospholipid syndrome
Cardiac involvement in scleroderma
Cardiac involvement in systemic vasculitis
Cardiovascular involvement in ankylosing spondylitis
Cardiovascular involvement in psoriatic arthritis
Cardiovascular involvement in primary Sjögren's syndrome
Gout and heart disease: a two way street?
Heart involvement in osteoarthritis
Cardiac effects of antirheumatic drugs
Index.Digital Access ScienceDirect 2017 - Digitalby El-Sayed H. Ibrahim.Contents:
[vol. 1]. Mathematical modeling, pulse sequences, and image analysis
[vol. 2]. Advanced techniques, clinical applications, and future trends.Digital Access - Digitaledited by Simon Stewart, Karen Sliwa, Ana Mocumbi, Albertino Damasceno, Mpiko Ntsekhe.Contents:
Maternal heart health / Karen Sliwa
Congenital heart disease / Ana Mocumbi, Tantchou Tchoumi, John Musuku
Acquired heart disease / Ana Mocumbi, Liesl Zuhlke, Peter Zilla
Cardiovascular risk in urban & rural African settings / Kemi Tibarzarwa, Karen Sliwa, Melinda J Carrington, Okechukwu S Ogah, and Simon Stewart
The African INTERHEART STUDY / Krisela Steyn and Karen Sliwa
The spectrum of heart disease in urban Africans : the heart of Soweto study / Melinda Carrington, Karen Sliwa and Simon Stewart
Rheumatic heart disease / Simon Stewart, Melinda Carrington & Karen Sliwa
Pericardial disease / Mpiko Ntsekhe
Human immunodeficiency virus-related heart disease / Friedrich Thienemann, Melinda Carrington, Karen Sliwa, Mpiko Ntsekhe & Simon Stewart
Acute coronary syndrome in the African context / Anthony Becker
Stroke in the African context / Albertino Damasceno
Acute heart failure / Mahmoud Sani, Dike Oji, Anastase Dzudie, Okechukwu Sam Ogah
Hypertensive heart failure / Dike Ojji, Mahmoud Sani, Anastase Dzudie, Okechukwu Sam Ogah
Chronic heart failure / Okechukwu Sam Ogah, Anastase Dzudie, Dike OJJi, Mahmoud Sani
Pulmonary hypertension & right heart failure / Anastase Dzudie, Friedrich Thienemann, Okechukwu Sam Ogah, Dike Ojji, Mahmoud Sa.Digital Access Wiley 2016 - DigitalCesare Terracciano, Samuel Guymer, editors.Summary: This textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed. All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College's BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.
Contents:
Anatomy of the Heart and Coronary Vasculature
Early Mechanisms of Cardiac Development
Later Mechanisms of Cardiac Development
Myocardial Microstructure and Contractile Apparatus
An Introduction to the Cardiac Action Potentials
Cardiac Excitation-Contraction Coupling
Conduction in Normal and Diseased Myocardium
Cell-Based Tachyarrhythmias and Bradyarrhythmias
The Scientific Rationale of Artificial Pacing
Cardiac Contractility
The Scientific Basis of Heart Failure
Molecular and Cellular Basis of Cardiomyopathies
Substrate Remodelling Changes in Heart Failure
Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs
Pharmacological Targets of Hypertension
The Coagulation Cascade and its Therapeutic Modulation
Cellular and Molecular Mechanisms of Atherosclerosis
Molecular and Cellular Mechanisms of Angiogenesis
Endothelial Function in Normal and Diseased Vessels.Digital Access Springer 2019 - DigitalJ. Anthony Gomes.Summary: This engaging book covers a multitude of topics related to heart rhythm disorders (HRDs) and uniquely familiarizes readers with the development of treatment modalities over the past several decades, including the evolution of anti-arrhythmic drugs, pacemakers, defibrillators, and catheter ablation. Organized in ten sections, this title serves as both an archival and a contemporary resource for clinicians. The first section describes the discovery of the circulatory system by William Harvey in 1628 and outlines the development and understanding of HRD since the advent of intra-cardiac electrophysiology. Subsequent sections discuss the historical evolution of abnormal heart rhythms, such as supra and ventricular rhythms and sudden cardiac death, their treatment with drugs, surgery, pacemakers, implantable defibrillators and catheter ablation. Section nine offers a fascinating narration of the clinical evolution of overcoming heart attacks and its impact on HRDs. The final section explores potential new frontiers in HRD and the factors that may contribute to the prospective rise of cardiovascular diseases. A ground-breaking and invaluable addition to the clinical literature, Heart Rhythm Disorders: History, Mechanisms and Management Perspectives details the pervasive nature of cardiovascular diseases in human history, their ramifications, and their projected effects on at-risk demographic populations and human health in general.
Contents:
The Discovery of the Circulatory System
The Road to Unearthing the Conducting System of the Heart
Understanding Heart Rhythm Disorders: The Birth of Clinical Cardiac Electrophysiology
Regular Supraventricular Tachycardia
The WPW Syndrome
The Road to Conquering Supraventricular Tachycardia
Atrial Fibrillation
Atrial Flutter
The Ventricular Premature Complex
Sudden Cardiac Death
Conquering the Substrate of Ventricular Tachycardia
Anti-Arrhythmic Drugs: Their Fall from Grace
Programmed Electrical Stimulation Guided Pharmacotherapy
The Implantable Defibrillator
Ablative Therapy for Ventricular Tachycardia
Sudden Death in the Athlete
The Channelopathies
Non-Invasive Risk-Stratification for Ventricular Arrhythmias
Hypothermia Post-Cardiac Arrest
The Common faint
The Sick Sinus Syndrome
Heart Blocks
The Artificial Pacemaker
The Evolution of Resynchronization Therapy
New Frontiers in Heart Rhythm Disorders
Waiting for a Heart Transplant
The Evolution of Coronary Bypass Surgery
The Discovery of Clot Dissolution
The Birth of Interventional Cardiology.Digital Access Springer 2020 - DigitalThierry Mesana, editor.Summary: This book provides a comprehensive framework for developing heart teams to manage a variety of cardiovascular diseases. Management of cardiovascular diseases has changed dramatically in recent years due to developments in evidence-based practices and treatments as well as the introduction of new devices. The sequential method of referring patients from doctor to doctor is becoming an antiquated model. The future of cardiac care lies in developing multidisciplinary "Heart Teams" to provide patient-focused treatment for complex cardiovascular problems. This volume examines the history and evolution of cardiovascular care and technology and explains why the implementation of heart teams is absolutely necessary to the future of cardiac care. It analyzes the role of heart teams for heart failure, complex coronary revascularization, mitral valve disease, cardiac imaging, aortic valve disease, cardiac arrhythmias, and women's heart health. Finally, the book explores how heart teams work with hospital administration and the broader healthcare industry. Heart Teams for Treatment of Cardiovascular Disease: A Guide for Advancing Patient-Centered Cardiac Care is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, cardiac surgery, critical care medicine, and radiology.
Contents:
Chapter 1. Introduction
Chapter 2. History of Cardiovascular Care and Heart Teams
Chapter 3. Heart Teams for Aortic Valve Disease
Chapter 4. Heart Teams for Mitral Valve Disease
Chapter 5. Heart Teams for Tricuspid Valve Disease
Chapter 6. Heart Teams for Heart Failure and Drug Implementation
Chapter 7. Heart Teams for Heart Transplantation
Chapter 8. Heart Teams for Artificial Heart Technology
Chapter 9. Heart Teams for Women's Heart Health
Chapter 10. Heart Teams for Coronary Artery Disease
Chapter 11. Heart Teams for Cardiac Arrhythmias
Chapter 12. Heart Teams for Cardiac Imaging
Chapter 13. Heart Teams and the ICU
Chapter 14. Heart Teams and Hospital Administration
Chapter 15. Heart Teams and the Healthcare Industry
Chapter 16. Heart Teams and Impact on Research and Innovation. - DigitalHashim Talib Hashim, Naseer Ahmed, Giuseppe Faggian, Martí Manyalich, Francesco Onorati, editors.Summary: This is a comprehensive translational reference covering a range of topics within heart transplantation. Including review of the procedure itself, preoperative requirements, potential complications and follow-up with the most up-to-date research and literature review, it introduces the embryology, anatomy, physiology, pathology and cardio-immunology of the heart. It also delves into other aspects of heart transplantation including organ procurement, religious aspects, the ethical issues that can emerge prior or during the surgery and discussion of the continued development of artificial hearts. The book explores multiorgan transplantation and their outcomes and complications. Heart Transplantation discusses the topic using illustrations and charts to aid understanding, allowing readers to gain a full understanding of the whole procedure easily. A list of practical surgical questions are presented at the end of each chapter to encourage the reader to challenge their understanding of the topic. With an emphasis on an interconnected approach to studying heart transplantation, this book presents a novel approach to educating surgeons in this challenging area of surgery. It is therefore an important addition to the literature for all involved in the management of heart transplantation from surgical residents to surgical nurses, cardiologists, anesthesiologists and experienced cardiac surgeons.
Contents:
Anatomy of the heart
Physiology of the heart
Embryology of the heart
Pathology of the heart diseases
Heart Transplantation Procedure
Complications and Follow up
Chapter VII: Cardioimmunology and heart transplantation
Organ Procurement
Ethical issues of heart transplantation
Religious aspects of heart transplantation
Multiorgan Transplantation including heart
Artificial heart
Heart Failure outcomes
General Principles in heart transplantation
Outcomes and Impact on quality of life. - DigitalJose Zamorano, Patrizio Lancellotti, Luc Pierard, Philippe Pibarot, editors.Summary: This book provides a state-of-the-art description of the pathophysiology, diagnosis and management of valvular heart disease (VHD). With an aging population, the incidence and complexity of VHD has markedly increased and the introduction of transcatheter valve therapies have revolutionized the management of these frequent and serious cardiovascular diseases. The development of percutaneous valve interventions has revolutionized the management of VHD (or has dramatically changed its management) Heart Valve Disease: State of the Art is dedicated to provide up-to-date knowledge to clinical and interventional cardiologists, cardiovascular imagers and cardiac surgeons. It provides state-of-the-art information for the health-care professional working in heart valve clinics, heart teams, and centers of excellence that specialize in managing patients with heart valve disease.
Contents:
Intro; Preface; Acknowledgements; Contents;
1: Introduction to Valve Heart Disease; Etiology of Valve Heart Disease; Rheumatic Fever; Calcific Valve Disease; Endomyocardial Fibrosis; Infectious Endocarditis; Valve Fibrous Structure Dilation; Chronic Systemic Inflammatory Disorders; Congenital Diseases; Drugs; Heart Valve Clinic; Models of Heart Valve Clinic; Available Evidence Regarding HVC; References;
2: Evaluation of Patients with Heart Valve Disease; Echocardiographic Evaluation of Valvular Heart Disease; Assessment of Valve Anatomy; Evaluation of Stenosis Severity Evaluation of Valvular RegurgitationEvaluation of Left Ventricular Geometry and Function; Right Heart Structure and Function; Aortic Anatomy; Prosthetic Valves and Infective Endocarditis; Other Echocardiographic Data; LV Diastolic Function and Filling Pressure; Pulmonary Pressures; References;
3: Aortic Stenosis; Introduction; Etiology and Epidemiology; Pathophysiology and Risk Factors; Pathophysiology of Calcific AS; Risk Factors and Potential Therapeutic Targets; Clinical Risk Factors; Genetic Risk Factors; Pathophysiology of LV Dysfunction and Symptoms in AS; Diagnosis and Management Grading AS SeverityAt Risk for AS (Grade 0 or Stage A); Mild or Moderate AS (Grades 1 and 2 or Stage B); Asymptomatic Severe AS (Grade 3 or Stage C); Symptomatic Severe AS (Grade 4 or Stage D); Discordant Grading with Low-Gradient AS; Staging Cardiac Damage; Selecting Surgical Versus Transcatheter Aortic Valve Replacement; Conclusions; References;
4: Aortic Regurgitation; Acute Aortic Regurgitation; Aetiology; Pathophysiology; Clinical presentation; Diagnosis; Management; Chronic Aortic Regurgitation; Aetiology; Pathophysiology; Clinical Presentation; Symptoms; Physical Examination; ECG Chest RadiographyDiagnosis; Transthoracic Echocardiography; TEE Examination; Other Imaging Modalities; Others; Natural History; Management; Follow-Up; References;
5: Aortic Valve Intraoperative Echocardiography; Transcatheter Aortic Valve Replacement (TAVR); Guiding the Procedure; Transapical Aortic Valve Replacement; Aortic Valve Repair; Reparability Assessment; Intraoperative TEE; Endocarditis; Paravalvular Leak Closure; Guiding the Procedure; References;
6: Mitral Stenosis; Aetiology; Physiopathology; Diagnosis; Symptoms; Physical Examination; Echocardiography; Positive Diagnosis MS Morphology Assessment by EchocardiographyQuantification of Severity; The Doppler Volumetric Method; The Proximal Isovelocity Surface Area (PISA) Method; Consequencies of MS; Exercise Testing/Stress Echocardiography; Catheterization; Medical Treatment; Percutaneous Mitral Commissurotomy (PMC); Surgical Procedures; Follow Up; References;
7: Mitral Regurgitation; Pathogenesis; Epidemiology; Aetiology; Primary Mitral Regurgitation; Secondary Mitral Regurgitation; Physiopathology; Clinical Presentation; Physical Examination; Diagnosis; Defining the Mechanism of Mitral Valve InsufficiencyDigital Access Springer 2020 - DigitalAmerican Heart Association.Summary: A workbook for students taking the American Heart Association's Heartsaver First Aid CPR AED course. Covers first aid basics, CPR for adults and how to use an AED.
Contents:
First aid basics
Medical emergencies
Injury emergencies
Environmental emergencies
CPR and AED
Conclusion
Summary of CPR and AED for adults, children, and infants.Digital Access AHA 2021 - DigitalAlexzander A.A. Asea, Punit Kaur, editors.Summary: The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
SECTION I: BIOMOLECULAR ASPECTS OF HSP60
Chapter 1. HSP60: A Story as Long as Life on the Earth
Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60
Chapter 3. HSP60 Inhibitors and Modulators
Chapter 4. HSP60 as Modulators of Apoptosis
Chapter 5. Utilizing The Unique Architecture And Abilities of HSP60 In Drug Development
Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease
SECTION II: HSP60 AND CANCER
Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology
Chapter 8. Exosomal HSP60: a Tumor Biomarker?
Chapter 9. HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities
Chapter 10. Hsp60 Involvement During Carcinogenesis
SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS
Chapter 11. Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases
Chapter 12. HSP60 In Inflammatory Disorders
SECTION IV: HSP60 AND CARDIOVASCULAR DISEASES AND DISORDERS
Chapter 13. HSP60 In Atherosclerosis
Past, Present and Future
Chapter 14. Cardiac Myopathy In Conditional HSP60 Transgenic Mice
SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES
Chapter 15. Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment
Chapter 16. HSP60 In Modifications of Nervous System Homeostasis and Neurodegeneration
SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS
Chapter 17. HSP60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology
Chapter 18. Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy
Chapter 19. Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity
SECTION VII: HSP60 IN HUMAN HEALTH
Chapter 20. Role of HSP60 In The Steroidogenesis and Reproduction
Chapter 21. Heat Shock Protein 60 in Skin Diseases. - DigitalAlexzander A.A. Asea, Punit Kaur, editors.Summary: The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
SECTION I: ONCOGENIC ASPECTS OF HSP90
Chapter 1. Regulatory Roles of HSP90-rich Extracellular Vesicles
Chapter 2. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease
Chapter 3. Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer
Chapter 4. Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?
Chapter 5. Role of Heat Shock Protein 90 in Mammary Tumorigenesis
Chapter 6. Role of HSP90 Inhibitors in the Treatment of Cancer
Chapter 7. p53-HSP90 Axis in Human Cancer
Chapter 8. HSP90 and its Inhibitors for Cancer Therapy: Use of Nano-delivery System to Improve its Clinical Application
Chapter 9. Hsp90 is a Pivotal Player in Retinal Disease and Cancer
Chapter 10. Targeting Hsp-90 Related Disease Entities for Therapeutic Development
Chapter 11. HSP90: A Key Player in Metal-Induced Carcinogenesis?
Section II: Biomolecular Aspects of HSP90
Chapter 12. Hsp90 and its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases
Chapter 13. Moonlighting Functions of Heat Shock Protein 90
Chapter 14. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target
Chapter 15. 'Complex World' of Hsp90 Co-chaperone R2TP
Chapter 16. Functions of SGT1, a Co-chaperone
Chapter 17. Sti1/Hop Plays a Pivotal Role in Hsp90 Regulation beyond Bridging Hsp70
Section III: HSP90 in Natural Products Development.-Chapter 18. Hsp90: A Target for Susceptibilities and Substitutions in Biotechnological and Medicinal Application
Chapter 19. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products
Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family
Section IV: Clinical Aspects of HSP90
Chapter 21. Hsp90 Chaperone in Disease
Chapter 22. Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis
Chapter 23. Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo
Chapter 24. Heat Shock Protein 90 in Severe Trauma
Chapter 25. HSP90
Is there an Unknown Role in Pain Neurobiology
Chapter 26. Heat Shock Protein 90 in Kidney Stone Disease
Chapter 27. HSP90 et al.
Chaperome and Proteostasis Deregulation in Human Disease. - DigitalAlexzander A.A. Asea, Punit Kaur, editors.Summary: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy
Chaperonin Hsp60 and Cancer Therapies
Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment
Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics
Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer
Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer
Heat Shock Proteins in Atrial Fibrillation
Threading Microarrays into Novel Applications
Regulation of Kaposi's Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones
Role of Heat Shock Factors in Diseases and Immunity
Heat Shock Proteins and Pain
Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway
Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions
Roles of Heat Shock Proteins on Antigen Presentation
Heat shock proteins mediate anastasis and plasticity of thermotolerant cells. - Digitaledited by Alexzander A.A. Asea, Punit Kaur.Summary: The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer's Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
Section I: Neurological Aspects of HSP
Chapter 1. Hsp60 Friend and Foe of the Nervous System
Chapter 2. Role of Heat Shock Proteins in Brain Tumors
Chapter 3. Body Temperature Regulation Determines Immune Reactions and Species Longevity
Chapter 4. Interaction between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System
Chapter 5. Role of HSP70 in Plasticity and Mem
Chapter 6. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke
Section II: Aspects of HSP in Neurodegenerative Diseases and Disorders
Chapter 7. Dysregulation of Heat Shock Proteins in Neurodegenerative Diseases: Restorative Roles of Small Molecules and Natural Compounds
Chapter 8. Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases
Chapter 9. Role of Hsp90 Interacting Molecular Chaperones on Tau And Ass Processing in Alzheimer's Disease
Section III: Aspects of HSP in Multiple Sclerosis
Chapter 10. Role of Hsp70 in Multiple Sclerosis: An Overview
Chapter 11. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis
Section IV: Development of HSP-Based Therapies for Neurological Disorders
Chapter 12. Therapeutic Drugs and Natural Products: The Effect of Suppressing Hsps in Brain Tumors
Chapter 13. Can HSP Targeted Gene Therapy be a New Hope for Gliomas?
Chapter 14. Therapeutic Aspects of Heat Shock Proteins in Glioma: Cementing the Crevasses between Bench and Bedside
Chapter 15. Engineering Chaperones for Alzheimer's Disease: Insights from Drosophila Models
Chapter 16. Role of HSP in the Treatment of Internal Dıseases. - DigitalAlexzander A.A. Asea, Punit Kaur, editors.Summary: This edited volume offers an insightful overview of contemporary research on signaling pathways. These signaling processes are the comprehensive mechanisms by which all cellular organisms communicate internally and externally with their microenvironment. The volume is focused on heat shock proteins (HSP), which are uniquely involved in a number of critical signaling pathways. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. The knowledge gained from better understanding these mechanisms can help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
Thiol-based Redox Signaling: Impacts on Molecular Chaperones and Cellular Proteostasis
Heat Shock Proteins (HSP) in Stress-Related Inflammatory Diseases
Heat Shock Response and Metabolism in Skeletal Muscle
Temperature Stress and Redox Homeostasis: The Synergistic Network of Redox and Chaperone System in Response to Stress in Plants
Dynamics of Heat Shock Proteins in Immunity and Aging
Heat Shock Proteins, Exercise and Inflammation
Heat Shock Proteins and Alarmins in Autoimmunity
HO-1/Hsp32 and Cardiac Stress Signaling
Targeting Heat Shock Proteins in Multiple Myeloma
IER5 is a p53-Reguated Activator of HSF1 that Contributes to Promotion of Cancer
Heat Shock Proteins in Digestive Tract Cancer: Molecular Mechanism and Therapeutic Potential
The Role of Heat Shock Protein 90 in Regulating Downstream Signal Transduction Cascades
Extracellular Hsp90a versus Intracellular Hsp90b in Wound Healing and Cancer
Regulation of Calcineurin Signaling through Blocking of the Chaperone Function of Hsp90 by HDAC Inhibitors
Signaling Functions of Extracellular Hsp90 (eHsp90) in Cancer Metastasis
The Role of the Molecular Chaperones Hsp70 and Hsp90 in the DNA Damage Response
Heat Shock Protein 90 Inhibitors in Lung Cancer Therapy
Hsp90 Inhibitors Blocking Multiple Oncogenic Signaling Pathways for the Treatment of Cancer
Diverse Roles of Heat Shock Proteins in Immune Activation and Tolerance: A Comprehensive Review of Mechanisms and Therapeutic Relevance
The Role of Heat Shock Proteins on Neuromuscular Disorders/Neuronal Differentiation
Heat Shock Proteins in Neural Signaling: Implications in Health and Disease
Cytosolic Heat Shock Protein 90 in Plant Hormone and Environmental Stress Response.Digital Access Springer 2019 - DigitalRobert J. Binder, Pramod K. Srivastava, editors.Summary: Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.
Contents:
Intro; Introduction and History; Contents; Part I: Structure of the HSPs in Relation to Chaperoning Peptides and Proteins;
Chapter 1: Hsp70-Substrate Interactions; 1.1 Introduction; 1.2 Hsp70 Functional Cycle; 1.3 Structural Basis for Hsp70-Substrate Interactions; 1.4 Mechanism of Action of Hsp70 Chaperones; 1.5 Interactions of Hsp70 Chaperones with Protein Substrates; 1.6 Role of Co-Chaperones; 1.7 Concluding Remarks; References;
Chapter 2: Molecular Chaperone Inhibitors; 2.1 The Hsp70 and Hsp90 Chaperone Cycle; 2.2 Hsp90 Inhibitors and Their Binding Sites; 2.2.1 Hsp90 N-Terminal Inhibitors. 2.2.2 Benzoquinone Ansamycin Inhibitors2.2.3 Radicicol and Analogous Inhibitors; 2.2.4 Additional Hsp90 Second-Generation Inhibitors; 2.2.5 Consequences of Different N-Terminal Inhibitors for Hsp90 Specificity and Conformation; 2.2.6 Hsp90 C-Terminal Inhibitors; 2.3 Grp94; 2.3.1 Allosteric Inhibitors of Grp94; 2.4 Hsp90 Co-Chaperone Inhibitors; 2.5 Hsp70/Hsc70; 2.6 Hsp70/Hsc70 Inhibitors and Their Binding Sites; 2.6.1 ATP-Competitive Inhibitors of Hsp70/Hsc70; 2.6.2 Allosteric Inhibitors of Hsp70/Hsc70; 2.6.3 Peptide Mimetics Targeting Hsp70/Hsc70; 2.7 Hsp40; 2.8 Small Hsps-Hsp27. 2.8.1 Antisense Oligonucleotides Targeting Hsp272.9 Small Hsps: Clusterin; 2.9.1 Antisense Oligonucleotides Targeting Clusterin; References; Part II: Exposure of HSPs to Immune Cells;
Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals; 3.1 Introduction; 3.2 Types of Cellular Communication; 3.3 Extracellular HSP as Communication Signals; 3.4 Extracellular HSP in Pathological Conditions; 3.5 Mechanisms of HSP Export; 3.6 The Stress Observation System; 3.7 Conclusions; References; Part III: Regulation of Immune Responses by Extracellular HSPs. 5.2 The Visionary Work of Dr. Eckhard Podack and Development of the State-of-the-Art Secreted gp96-Ig Vaccine Approach5.2.1 Construction of gp96-Ig; 5.2.2 Principles of Secreted gp96-Ig Vaccine Approach; 5.3 The State of the Knowledge of Antitumor Vaccination with gp96-Ig; 5.3.1 Allogeneic gp96 Vaccine; 5.3.2 Combined Therapeutic Approach; 5.4 The State of Knowledge of Anti-Infectious Vaccination with gp96-Ig; 5.4.1 Secreted SIV/HIV gp96-Ig Vaccine; 5.4.1.1 Gp96SIVIg as a Novel Adjuvant for Antibody Production.
Chapter 4: The Heat Shock Protein-CD91 Pathway and Tumor Immunosurveillance4.1 Heat Shock Proteins as Chaperones of Macromolecules; 4.2 Immune Responses Elicited by Extracellular HSPs; 4.3 Extracellular HSPs as the Molecular Signature for Immunological Responsiveness; 4.4 The Role of Extracellular HSPs in Tumor Immunosurveillance; 4.5 Conclusion; References;
Chapter 5: Bridging the Gaps in the Vaccine Development: Avant-Garde Vaccine Approach with Secreted Heat Shock Protein gp96-Ig; 5.1 Introduction. - DigitalAddmore Shonhai, Gregory L. Blatch, editors.Contents:
The Importance of Molecular Chaperones in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum / Jude Przyborski
General Structural and Functional Features of Molecular Chaperones / Adrienne L. Edkins and Aileen Boshoff
The Role of Hsp70s in the Development and Pathogenicity of Plasmodium Species / Addmore Shonhai
Role of the Hsp40 Family of Proteins in the Survival and Pathogenesis of the Malaria Parasite / Eva-Rachele Pesce, Alexander G. Maier and Gregory L. Blatch
Role of Hsp90 in Plasmodium falciparum Malaria / Dea Shahinas and Dylan R. Pillai
The Role of Parasite Heat Shock Proteins in Protein Trafficking and Host Cell Remodeling / Paul R. Gilson, Sarah C. Charnaud and Brendan S. Crabb
Role of Heat Shock Proteins in Immune Modulation in Malaria / Evelyn Böttger and Gabriele Multhoff
Establishment of Plasmodium falciparum Extracellular Compartments in its Host Erythrocyte / Alassane Mbengue, Laurence Berry and Catherine Braun-Breton
Chaperones and Proteases of Plasmodium falciparum / Kaiyin Liu and Walid A. Houry
Heat Shock Proteins as Targets for Novel Anti-Malarial Drugs / Manish Grover, Shweta Chaubey and Utpal Tatu
Heat Shock Proteins of Malaria: What Do We Not Know, and What Should the Future Focus Be? / Addmore Shonhai and Gregory L. Blatch.Digital Access Springer 2014 - DigitalAddmore Shonhai, Didier Picard, Gregory L. Blatch, editors.Contents:
Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum
Chapter 2. General Structural and Functional Features of Molecular Chaperones
Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum
Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria
Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells
Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria
Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery?
Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery
Chapter 10
Heat Shock Proteins of Malaria: Highlights and Future Prospects. - DigitalJulien D. Périard, Sébastien Racinais, editors.Summary: The book is designed to provide a flowing description of the physiology of heat stress, the illnesses associated with heat exposure, recommendations on optimising health and performance, and an examination of Olympic sports played in potentially hot environmental conditions. In the first section the book examines how heat stress effects performance by outlining the basics of thermoregulation and how these responses impact on cardiovascular, central nervous system, and skeletal muscle function. It also outlines the pathophysiology and treatment of exertional heat illness, as well as the role of hydration status during exercise in the heat. Thereafter, countermeasures (e.g. cooling and heat acclimation) are covered and an explanation as to how they may aid in decreasing the incidence of heat illness and minimise the impairment in performance is provided. A novel and particular feature of the book is its inclusion of sport-specific chapters in which the influence of heat stress on performance and health is described, as well as strategies and policies adopted by the governing bodies in trying to offset the deleterious role of thermal strain. Given the breadth and scope of the sections, the book will be a reference guide for clinicians, practitioners, coaches, athletes, researchers, and students.
- Digital/PrintKiese Laymon.Summary: "Laymon writes eloquently and honestly about the physical manifestations of violence, grief, trauma, and abuse on his own body. He writes of his own eating disorder and gambling addiction as well as similar issues that run throughout his family. Through self-exploration, storytelling, and honest conversation with family and friends, Heavy seeks to bring what has been hidden into the light and to reckon with all of its myriad sources, from the most intimate--a mother-child relationship--to the most universal--a society that has undervalued and abused black bodies for centuries"-- Provided by publisher.
Contents:
Boy man. Train ; Nan ; Wet ; Be
Black abundance. Meager ; Contraction ; Hulk ; Gumption
Home worked. Fantastic ; Disaster ; Already ; Soon
Addict Americans. Greens ; Terrors ; Seat belts ; Promises.Digital Access EBSCO 2018Limited to 1 simultaneous user - Digitaledited by Natalia A. Riobo.Contents:
Luciferase reporter assays to study transcriptional activity of hedgehog signaling in normal and cancer cells / Silvia Pandolfi and Barbara Stecca
Measuring expression levels of endogenous gli genes by immunoblotting and real-time PCR / Pawel Niewiadomski and Rajat Rohatgi
Quantitative immunoblotting of endogenous hedgehog pathway components / Shohreh F. Farzan and David J. Robbins
Measuring Gli2 phosphorylation by selected reaction monitoring mass spectrometry / Robert Ahrends, Pawel Niewiadomski, Mary N. Teruel, and Rajat Rohatgi
Rapid screening of Gli2/3 mutants using the Flp-In system / Pawel Niewiadomski and Rajat Rohatgi
Insights into gli factors ubiquitylation methods / Paola Infante, Romina Alfonsi, and Lucia Di Marcotullio
Determination of acetylation of the gli transcription factors / Sonia Coni, Laura Di Magno, and Gianluca Canettieri
Efficient detection of indian hedgehog during endochondral ossification by whole-mount immunofluorescence / João Francisco Botelho, Daniel Smith-Paredes, and Veronica Palma A.
Methods for detection of Ptc1-driven LacZ expression in adult mouse skin / Donna M. Brennan-Crispi, My G. Mahoney, and Natalia A. Riobo
Determination and analysis of cellular metabolic changes by noncanonical hedgehog signaling / Raffaele Teperino and John Andrew Pospisilik.Digital Access Springer 2015 - DigitalNayoung Kim, editor.Contents:
Part 1. Epidemiology-Prevalence and Transmission routes of H. pylori
Part 2. Pathophysiology
1) Colonization of H. pylori in the stomach
2) Brief description of Pathophysiology
3) Immune mechanism
4) Change of acid secretion, ghrelin and leptin by H. pylori
5) H. pylori virulence factors
A: toxin (CagA, VacA, DupA, OipA, IceA)
B: genetic polymorphism of toxin and disease
6) Host factors: genetic polymorphism, etc
Part 3. Diagnosis
1) Serology
2) Histology
3) Culture
4) UBT
5) Stool antigen
6) Specific conditions
A: Children
B: Bleeding
Part 4. Symptom
1)Symptom of acute and chronic H. pylori infection
Part 5. Disease
1) Atrophic gastritis and Intestinal metaplasia
2) Functional dyspepsia
3) Peptic ulcer
4) MALToma
5) Gastric cancer
A: Synopsis and Epidemiology of gastric cancer
B1: Pathogenesis: i.Genetic alternation (mutations in tumor-related genes) induced by Activation-induced cytidine deaminase (AID)
B2: Pathogenesis: ii. Epigenetic mechanisms: aberrant DNA methylation, microRNA
B3: Pathogenesis:iii. Macrophage inhibitory factor (MIF)
B4: Pathogenesis: iv. Epidermal mesenchyme transition (EMT)
B5: Pathogenesis: v. ABO blood type
B6: Pathogenesis: vi. First relatives of gastric cancer
C: H. pylori-negative gastric cancer
6) Gastroesophageal reflux disease (GERD)
7) NSAID-induced gastropathy and H. pylori infection
8) Extraintestinal manifestations of H. pylori infection
A: Iron deficiency anemia
B: Idiopathic thrombocytopenic purpura
C: Heart disease
D: Atopy and allergy
Part 6. Antibiotic resistance
1) Synopsis of antibiotic resistance
2) Clarithromycin
3) Amoxicillin
4) Quinolone
5) Metronidazole
Part 7. Treatment
1) Synopsis of antibiotic treatment
2) Triple therapy
3) Quadruple therapy
4) Sequential therapy
5) Concomitant therapy
6) Tailored therapy based on antibiotic resistance
7) Levofloxacin or rifabutin based triple therapy
8) Probiotics
9) Treatment guidelines
10) Screening method of early gastric cancer
11) Recrudescence and reinfection
Part 8. Consequences of H. pylori eradication
1) Peptic ulcer disease
2) atrophic gastritis and Intestinal metaplasia
3) Gastric cancer
Part 9. The effect of H. pylori on the other microbiota of stomach
The effect of H. pylori on the other microbiota of stomach
Part 10. Animal model- H. pylori, H. felis. - DigitalShigeru Kamiya, Steffen Backert, editors.
- DigitalSusan Young and Jade Smith.Contents:
The Young-Smirth programme
Introduction to Buss and his family
Attention
Hyperactivity
Impulsivity
Anxiety
Frustration and anger
Social skills and relationships
Setting goals and planning ahead
Problem solving
Mood and self-esteem.Digital Access Wiley 2017 - Digitaledited by Fadi Haddad, M.D., Ruth S. Gerson, M.D.Summary: Helping Kids in Crisis: Managing Psychiatric Emergencies in Children and Adolescents is a practical, easy-to-use guide for clinicians working with child and adolescent psychiatric emergencies across a range of settings -- from emergency rooms to schools to community pediatric or mental health clinics.
Contents:
Introduction / Susan B. Torrey, M.D.
1. Kids in Crisis / Fadi Haddad, M.D.
2. Aggression / Ruth Gerson, M.D., and Fadi Haddad, M.D.
3. Suicide and Self-Injurious Behaviors / Gabrielle S. Carson, Ph. D.
4. Tantrums and Behavioral Outbursts / M. Cevdet Tosyali, M.D.
5. The "Odd" Child / Rachel Mandel, M.D.
6. Child Abuse and Trauma / Ruth Gerson, M.D.
7. Risky Behaviors / Charles J. Glawe, M.D.
8. Clinical and Forensic Psychological Issues With At-Risk Youths and Juvenile Delinquents / Alessandra D.E. Herbosch, Psy. D.
9. Substance Use: HELPING TEENAGERS AND FAMILIES WORK THROUGH A SUBSTANCE USE CRISIS / J. Rebecca Weis, M.D., and Stephen Ross, M.D.
10. Finding Help: HELPING FAMILIES FIND EFFECTIVE TREATMENT FOR CHILDREN WITH PSYCHIATRIC ILLNESS / Jasmine Marrero, LCSW, Melissa Negron, LCSW, and Maggie Bielsky, LMSW
11. Models of Emergency Psychiatric Care for Children and Adolescents: MOVING FROM TRIAGE TO MEANINGFUL ENGAGEMENT IN MENTAL HEALTH TREATMENT / Jennifer F. Havens, M.D., and Mollie C. Marr, B.F.A.
Index.Digital Access PsychiatryOnline 2015 - Digitaledited by Mina K. Dulcan, M.D., Rachel R. Ballard, M.D.Contents:
Contributors
Introduction for Clinicians to the Fourth Edition
Selected Additional Reading for Health and Mental Health Professionals
Published Resources for Parents and Teachers
Information on the Internet
Copyright, Citation, and Disclaimer
Appendix 1: Medicines With FDA Indication for Attention-Deficit/Hyperactivity Disorder (ADHD)
Appendix 2: Medicines Typically Used for Anxiety and Depression
Appendix 3: Medicines Typically Used for Psychosis
Appendix 4: Medicines Typically Used for Mood Stabilization or Reducing Aggression Drugs by Generic and Brand Names: Alprazolam (Xanax)
Amitriptyline
Amphetamine (Dexedrine, ProCentra, Zenzedi, Adderall, Vyvanse)
Aripiprazole (Abilify) --Asenapine (Saphris)
Atenolol (Tenormin)
Atomoxetine (Strattera)
Benzodiazepines Used for Sleep: Estazolam (ProSom), Flurazepam, Temazepam (Restoril), Triazolam (Halcion)
Benztropine (Cogentin)
Bupropion (Wellbutrin, Aplenzin, Forfivo)
Buspirone
Carbamazepine (Tegretol, Carbatrol, Epitol, Equetro, Tegretol XR)
Chlorpromazine
Citalopram (Celexa)
Clomipramine (Anafranil)
Clonazepam (Klonopin)
Clonidine (Catapres, Catapres-TTS, Kapvay)
Clozapine (Clozaril, FazaClo, Versacloz)
Cyproheptadine
Desipramine (Norpramin)
Desmopressin Acetate (DDAVP, Stimate)
Diazepam (Valium)
Diphenhydramine (Benadryl)
Duloxetine (Cymbalta)
Escitalopram (Lexapro)
Fluoxetine (Prozac, Symbyax)
Fluphenazine
Fluvoxamine (Luvox CR)
Gabapentin (Neurontin, Gralise, Gralise Starter)
Guanfacine (Tenex, Intuniv)
Haloperidol (Haldol)
Hydroxyzine (Vistaril)
Hypnotics-Sleep Medications (Nonbenzodiazepines): Eszopiclone (Lunesta), Zaleplon (Sonata), Zolpidem (Ambien, Ambien CR, Edluar, Intermezzo, Zolpimist)
Iloperidone (Fanapt)
Imipramine (Tofranil)
Lamotrigine (Lamictal, Lamictal XR)
Levomilnacipran (Fetzima)
Lithium (Lithobid)
L-methylfolate (Deplin)
Lorazepam (Ativan)
Loxapine (Loxitane, Adasuve)
Lurasidone (Latuda)
Melatonin
Metformin (Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet)
Methylphenidate (Methylin, Ritalin, Metadate, Concerta, Daytrana, Quillivant, Focalin)
Mirtazapine (Remeron)
Modafinil (Provigil), Armodafinil (Nuvigil)
N-acetylcysteine
Nortriptyline (Pamelor)
Olanzapine (Zyprexa, Symbyax)
Omega-3 Fatty Acids (Epanova, Lovaza)
Oxcarbazepine (Trileptal, Oxtellar XR)
Paliperidone (Invega)
Paroxetine (Paxil, Pexeva, Brisdelle, Paxil CR)
Perphenazine
Pimozide (Orap)
Pindolol
Prazosin (Minipress)
Propranolol (Inderal)
Quetiapine (Seroquel)
Ramelteon (Rozerem)
Risperidone (Risperdal)
Sertraline (Zoloft)
Thiothixene
Topiramate (Topamax, Topiragen, Trokendi XR, Qudexy SR)
Trazodone (Oleptro)
Trifluoperazine
Valproic Acid (Depakene, Stavzor), Divalproex (Depakote, Depakote ER, Depakote Sprinkles)
Venlafaxine (Effexor), Desvenlafaxine (Pristiq, Khedezla)
Vilazodone (Viibryd)
Vortioxetine (Brintellix)
Ziprasidone (Geodon).Digital Access PsychiatryOnline 2015 - DigitalRaul Mattassi, Dirk A. Loose, Massimo Vaghi, editors ; foreword by J. Leonel Villavicencio.Contents:
I. Introduction and General Overview
1.Vascular Embryology
2. Molecular and Genetic Aspects in Infantile Hemangiomas and Vascular Malformations
3. Introduction and Background Notes
4. Clotting Problems
II. Hemangiomas and Vascular Tumors
5. Hemangiomas in Infancy: Epidemiology
6. Classification of Infantile Hemangiomas and Other Congenital Vascular Tumors
7. Clinical Picture
8. Diagnostics of Infantile Hemangiomas Including Visceral Hemangioma
9. Principles of Treatment
10. Propanolol and Betablockers in Medical Treatment of Infantile Hemangiomas
11. Other Medical Treatments of Infantile Hemangiomas and Other Vascular Tumors
12. Laser Treatment of Infantile Hemangiomas
13. Surgical Treatment
14. Treatment by Embolization
15. Treatment of Infantile Laparoscopic Rectal Anterior Resection in Head and Neck
16. Treatment of Visceral Infantile Hemangiomas
17. Treatment of Genital Infantile Hemangiomas
18. Management of Syndromes Related to Infantile Hemangiomas
III. Vascular Malformations
19. Epidemiology
20. Histology in Vascular Malformations
21. Classifications
22. Principles of Diagnostics
23. Clinical Aspects in Vascular Malformations
24. Dermatologic Aspects in Vascular Malformations
25. Ultrasound Diagnostics
26. Role of MR and CT in Diagnostics
27. Nuclear Medicine
28. Angiography and Phlebography
29. Principles of Treatment
30. Surgical Techniques and Tactics in Vascular Malformations
31. Interventional Treatment in AVM
32. Principles and Technical Skills in Ethanol Treatment of Vascular Malformations
33. Sclerosis in Vascular Malformations
34. Laser Treatment of Vascular Malformations
35. Possibilities and Limits of Medical Treatment
36. Approach to Syndromes in Vascular Malformations
IV. Treatment of Problems According to Specific Localizations
37. Introduction
38. Head and Neck Malformations: Surgical Treatment
39. Head and Neck Malformations: Sclerosis Treatment
40. Treatment of Upper Airway Involvement
41. Treatment of Intraorbital Vascular Malformations
42. Orthopedic Problems,
43. Treatment of Vascular Malformations of the Hand
44. Thorax Wall
45. Visceral Vascular Malformations
46. Pelvic Malformation
47. Vascular Malformations of the Limbs: Treatment of Arterio-Venous and Venous Malformations
48. Lymphatic Vascular Malformations of the Limbs: Treatment of Extratruncular Malformations
49. Lymphatic Vascular Malformations of the Limbs: Conservative Treatment of Truncular Malformations
50. Lymphatic Truncular Malformations of the Limbs: Surgical Treatment
51. Thoracic Duct Dysplasia and Chylous Reflux
52. Conclusions
Subject Index.Digital Access Springer 2015 - DigitalJanet S. Lee, Michael P. Donahoe, editors.Contents:
Part I: Overview
The Lung-Blood Interface
Leukocyte Kinetics and Migration in the Lungs
Part II: Acute Pulmonary Manifestations Arising from Primary Hematologic Disorders
Sickle Cell and Acute Chest Syndrome: Mechanisms and Pathogenesis
Sickle Cell Disease and Acute Chest Syndrome: Epidemiology, Diagnosis, Management, Outcomes
Thrombophilias and Acute Pulmonary Thromboembolic Disease
Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic Complications in the Intensive Care Unit
Acute Pulmonary Manifestations of Hematologic Malignancies
Acute Pulmonary Complications of Bone Marrow and Stem Cell Transplantation
Part III: Transfusion-Related Complications
Storage Lesion: Evolving Concepts and Controversies
Transfusion and Acute Respiratory Distress Syndrome: Pathogenesis and Potential Mechanisms
Transfusion and Acute Respiratory Distress Syndrome: Clinical Epidemiology, Diagnosis, Management, and Outcomes
Transfusion Associated Circulatory Overload
Transfusion-Related Immunomodulation (TRIM): From Renal Allograft Survival to Postoperative Mortality in Cardiac Surgery.Digital Access Springer 2017 - DigitalAryeh Shander, Howard L. Corwin, editors.Summary: This volume provides a comprehensive overview of hematologic issues that clinicians regularly encounter in the critical care environment. The text features hematologic scenarios that affect the adult ICU patient, outlines pathogenesis and challenges associated with the hematologic disorder, and offers treatment modalities. Hematologic issues covered include anemia, hemostatic abnormalities, and risks of transfusion. The book also details challenges in specific ICU populations, such as patients afflicted with liver disease, brain injury, sepsis, cardiovascular disease, malignancy, and trauma. Written by experts in the field, Hematologic Challenges in the Critically Ill is a valuable resource for clinicians in the critical care environment who treat critically ill patients afflicted with hematologic complications.
Contents:
Anemia in the Critically Ill
Hemostatic Abnormalities in the Critically Ill
Advances in Hematologic Testing
Current and Emerging Technologies in Hematologic Testing
Hematologic Impact of Fluid Replacement
Advances in Trauma Resuscitation
Hematologic Issues in Sepsis
Hematologic Challenges in ICU Patients with Cardiovascular Disease
Hematologic Challenges in ICU Patients with Liver Disease and Gastrointestinal Hemorrhage
Hematological Challenges in Intensive Care Unit Patients with Neurological Disease
Hematologic Challenges in the Critically Ill: Obstetrics
Hematologic Challenges in ICU Patients with Malignancy
Hematologic Challenges in ICU Patients on ECMO
Hematologic Challenges in Intensive Care Unit Patients with Solid Organ Transplants
Risks of Transfusion
Clinical Outcomes and Red Blood Cell Storage
Anticoagulants in the ICU
Hematologic Challenges in ICU Patients Needing Plasma Exchange
Intravenous Oxygen Therapeutics: A Revolution in Medicine yet to be Realized?
Role of Blood Bank, Transfusion Services and Pharmacy in ICU Patients with Hematologic Challenges
Patient Blood Management in Critically Ill. - DigitalManorama Bhargava.Summary: This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.
Contents:
Techniques in Cytogenetics
Techniques in Molecular Haematology
Part: I - Case Studies in Myeloid Malignancies
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Myelodysplastic Syndromes - Myeloproliferative Neoplasms
Myeloproliferative Neoplasms
Chronic Myeloid Leukemia
Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages
Part: II - Case Studies in Lymphoid Malignancies
Acute Lymphoblastic Leukemia
Chronic Lymphocytic Leukemia and Non Hodgkins Lymphoma
Part: III - Case Studies in Multiple Myeloma
Multiple Myeloma. - DigitalGiorgio Berlot, Gabriele Pozzato, editors.Summary: This book covers a wide array of hematologic problems commonly encountered in the daily practice of critical care and emergency medicine. Unfortunately, the symptoms and signs associated with underlying hematologic disorders are frequently rather unspecific and confounding; furthermore, the clinical course of patients admitted to intensive care units with such disorders can be fulminant, warranting prompt diagnosis. This book recognizes the importance of accurate and speedy interpretation of symptoms in that the text is symptom oriented rather than disease oriented. Put another way, the reader confronted with a particular clinical problem or symptom will be guided step by step to the possible underlying disorder(s). The scenarios considered include critical illness in patients with anemia, leukopenia, leukocytosis, abnormal platelet count, and severe transfusion reactions. For each circumstance, factors relevant to symptom interpretation are fully discussed. In addition, helpful diagnostic algorithms are presented in the form of flow charts that will assist in decision making regarding the need for further investigations. The closing chapter is devoted to the drug-induced hematologic disorders. Although the book is intended mainly for intensivists, other specialists will find much information of value for their daily practice.
Contents:
Introduction
Anemia
Anemia in the Critically Ill Patients
Leukopenia in the Critically Ill Patients
Leukocytosis in the Critically Ill Patients
The critically ill patient with abnormal platelet count
Transfusion adverse reactions in critically ill patients
Drugs and blood cells. - DigitalEiichi Ishii, editor.Contents:
Part I. Hematopoiesis
1. Hematopoietic stem cells: the basis of normal and malignant hematopoiesis
Part II. White blood cell disorders
2. Acute lymphoblastic leukemia
3. Acute myeloid leukemia
4. Myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML)
5. Neutropenia (in infancy and childhood)
Part III. Red blood cell disorders
6. Childhood aplastic anemia
7. Inherited bone marrow failure syndrome, TAM
Part IV. Platelet and coagulation disorders
8. Immune and inherited thrombocytopenia in children
9. Pathogenesis and treatment of hemophilia
10. Thrombotic disorders
Part V. Histiocytic disorders
11. Langerhans cell histiocytosis
12. Primary hemophagocytic lymphohistiocytoosis
13. Hemophagocytic lymphohistiocytosis, secondary.Digital Access Springer 2017 - PrintRobert M. Schmidt, section editor.
- DigitalS. David Hudnall.Summary: "Gain a foundational understanding of complex hematology concepts with this thoroughly revised text. Hematology: A Pathophysiologic Approach, 2nd Edition, a volume in theMosby Physiology Series explains the fundamentals of this multi-faceted area in a clear and concise manner. It offers masterful explanations of hematopoiesis, immunology, hemostasis, hemoglobinopathy, metabolic disorders, genetics, and neoplasia from S. David Hudnall, MD, Professor Emeritus of Pathology and Laboratory Medicine at Yale University School of Medicine. Prof. Hudnall, who has practiced laboratory hematology and hematopathology for more than 30 years, has taught the principles of hematology to thousands of pre-medical undergraduates and medical students. Rich, clinically oriented coverage from cover to cover makes this text an ideal, problem-based way to learn about this complex subject"-- publisher's description.
Contents:
Brief overview of the hematolymphoid system
Hematopoiesis
Erythropoiesis and oxygen transport
Iron, heme, and hemoglobin
Hemoglobinopathy
Red blood cell metabolism and enzyme defects
Hemolytic anemia
Aplastic anemia and related disorders
Megaloblastic anemia
Myeloid cells
Immune system and related disorders
Genetic basis of hematologic neoplasia
Leukemia and related disorders
Lymphoma and related disorders
Blood coagulation
Platelets
Benign conditions of lymphoid organs
Blood transfusion and stem cell transplantation
Hematologic cancer therapy.Digital Access ClinicalKey [2024] - Digital[edited by] Ronald Hoffman, Edward J. Benz, Jr., Leslie E. Silberstein, Helen E. Heslop, Jeffrey I. Weitz, John Anastasi, Mohamed Salama.Summary: "Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field"--Publisher's description.
Contents:
Anatomy and physiology of the gene
Epigenetics and epigenomics
Genomic approaches to hematology
Regulation of gene expression, transcription, splicing and RNA metabolism
Protein synthesis, processing, and trafficking
Protein architecture: relationship of form and function
Signaling transduction and metabolomics
Pharmacogenomics and hematologic diseases
Hematopoietic stem cell biology
Stem cell model of hematologic malignancies
Hematopoietic microenvironment
Cell adhesion
Hematopoietic cell trafficking and chemokines
Interactions between hematopoietic stem and progenitor cells and the bone marrow: current biology of stem cell homing and mobilization
Vascular growth in health and disease
Cytokine/receptor families and signal transduction
Control of cell division
Cell death
Overview and compartmentalization of the immune system
B-cell development
T-cell immunity
Natural killer cell immunity
Dendritic cell biology
Complement and immunoglobulin biology leading to clinical translation
Tolerance and autoimmunity
Biology of erythropoiesis, erythroid differentiation, and maturation
Granulocytopiesis and monocytopoiesis
Thrombocytopoiesis
Inherited forms of bone marrow failure
Aplastic anemia
Paroxysmal nocturnal hemoglobinuria
Acquired disorders of unilineage blood cell production
Pathobiology of the human erythrocyte and its hemoglobins
Approach to anemia in the adult and child
Pathophysiology of iron homeostasis
Disorders of iron metabolism: iron deficiency and overload
Anemia of chronic diseases
Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias
Megaloblastic anemias
Thalassemia syndromes
Pathobiology of sickle cell disease
Sickle cell disease: clinical features and management
Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias
Red blood cell enzymopathies
Red blood cell membrane disorders
Autoimmune hemolytic anemia
Extrinsic nonimmune hemolytic anemias
Granulocytosis, granulocytopenia, monocytosis, and monocytopenia
Lymphocytosis, lymphocytopenia, hypergammaglobulinemia, and hypogammaglobulinemia
Disorders of phagocyte function
Congenital disorders of lymphocyte function
Histiocytic disorders
Lysosomal storage diseases: perspectives and principles
Infectious mononucleosis and other Epstein-Barr virus-associated diseases
Progress in the classification of hematopoietic and lymphoid neoplasms: clinical implications
The cytogenomic basis of hematological malignancies
Pharmacology and molecular mechanisms of antineoplastic agents for hematologic malignancies
Pathobiology of acute myeloid leukemia
Clinical manifestations and treatment of acute myeloid leukemia
Myelodysplastic syndromes: biology and treatment
Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults
Acute myeloid leukemia in children
Myelodysplastic syndrome and myeloproliferative syndrome in children
Pathobiology of acute lymphoblastic leukemia
Clinical manifestations and treatment in children of acute lymphoblastic leukemia
Acute lymphocytic leukemia in adults
Chronic myeloid leukemia
The polycythemias
Essential thrombocythemia
Primary myelofibrosis
Eosinophilia, eosinophil-associated diseases, chronic eosinophil leukemia, and the hypereosinophilic syndromes
Mast cells and systemic mastocytosis
The pathologic basis for the classification of non-Hodgkin and Hodgkin lymphomas
Origins of Hodgkin disease
Hodgkin lymphoma: clinical manifestations, staging, and therapy
Origins of non-Hodgkin lymphomas
Chronic lymphocytic leukemia
Hairy cell leukemia
Clinical manifestations and treatment of indolent lymphomas: marginal zone lymphomas (extranodal/malt, splenic, and nodal)
Clinical manifestations, staging, and treatment of follicular lymphoma
Mantle cell lymphoma
Diagnosis and treatment of diffuse large b-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)
Viral-related lymphomas
Malignant lymphomas in childhood
T-cell lymphomas
Multiple myeloma
Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma
Immunoglobuin light-chain amyloidosis (primary amyloidosis)
Clinical approach to infections in the compromised host
Psychosocial aspects of hematologic disorders
Pain management and antiemetic therapy in hematologic disorders
Palliative care
Late complications of hematologic diseases and their therapies
Overview and historical perspective of current cell-based therapies
Practical aspects of hematologic stem cell harvesting and mobilization
IND enabling processes for cell-based therapies
Graft engineering and cell processing
Principles of cell-based genetic therapies
Mesenchymal stromal cells
T cell therapy of hematological diseases
NK cell-based therapies
Immune checkpoint blockade in hematologic malignancies
Overview and choice of donor of hematopoietic stem cell transplantation
Indications and outcomes of allogeneic hematopoietic cell transplantation for hematologic malignancies in adults
Unrelated donor hematopoietic cell transplantation
Haploidentical hematopoietic cell transplantation
Unrelated donor cord blood transplantation for hematologic malignancies
Graft-versus-host disease and graft-versus-leukemia responses: biology and therapy
Complications after hematopoietic cell transplantation
Human blood group antigens and antibodies
Principles of red blood cell transfusion
Clinical considerations in platelet transfusion therapy
Human leukocyte antigen and human neutrophil antigen systems
Principles of neutrophil (granulocyte) transfusions
Transfusion of plasma derivatives: plasma, cryoprecipitate, albumin, and immunoglobulins
Preparation of plasma-derived and recombinant human plasma proteins
Transfusion therapy for coagulation factor deficiencies
Hemapheresis
Transfusion reactions to blood and cell therapy products
Transfusion-transmitted diseases
Pediatric transfusion medicine
Overview of hemostasis and thrombosis
The blood vessel wall
Megakaryocyte and platelet structure
Molecular basis of platelet function
Molecular basis of blood coagulation
Regulatory mechanisms in hemostasis
Clinical approach to the patient with bleeding or bruising
Laboratory evaluation of hemostatic and thrombotic disorders
Acquired disorders of platelet function
Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura
Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution
Heparin-induced thrombocytopenia
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndromes
Hemophilia A and B
Inhibitors in hemophilia A and B
Rare coagulation factor deficiencies
Structure, biology, and genetics of von Willebrand factor
Disseminated intravascular coagulation
Hypercoagulable states
The antiphospholipid syndrome
Venous thromboembolism
Mechanical interventions in arterial and venous thrombosis
Atherothrombosis
Stroke
Acute coronary syndromes
Atrial fibrillation
Peripheral artery disease
Antithrombotic drugs
Disorders of coagulation in the neonate
Hematologic changes of pregnancy
Hematologic manifestations of childhood illness
Hematologic manifestations of systemic disease: liver disease
Hematologic manifestations of systemic disease: renal disease
Hematologic manifestations of cancer
Integrated therapies in patients with hematologic diseases
Hematologic manifestations of aids
Hematologic manifestations of parasitic diseases
Hematologic problems in the surgical patient: bleeding and thrombosis
The spleen and its disorders
Hematology in aging.Digital Access ScienceDirect 2018 - Digital[edited by] Ronald Hoffman, Edward J. Benz, Jr., Leslie E. Silberstein, Helen E. Heslop, Jeffrey I. Weitz, Mohamed E. Salama, Syed A. Abutalib.Digital Access ClinicalKey 2023
- Digitaledited by Robin K. Ohls, Akhil Maheshwari, Robert D. Christensen ; consulting editor, Richard A. Polin.Summary: Dr. Richard Polin's Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.
Contents:
Stem cell therapy in neonates-the time has (almost) come
Genome and Exome Sequencing: Can it impact clinical care in the NICU
Transfusion thresholds in the NICU-what have recent RCTs taught us
Donor milk compard with mother's own milk
Will standardized approaches to nutrition decrease NEC
What is the value of identifying genetic causes of congenital hemolytic jaundice
Using the New CBC Parameters in NICU Practice
How near are we to using darbepoetin or erythropoietin as neuroprotective agents for perinatal hypoxic/ischemic encephalopathy
Of what value to neonates is measuring end tidal carbon monoxide concentration
How do we adopt anemia-preventing strategies in our delivery rooms
Thrombocytopenia in Infants with Necrotizing Enterocolitis
Genetic Risk Factors for Patent Ductus Arteriosus
Genetic basis of PDA
Genetic basis of bronchpulmonary dysplasia
Prenatal genetic testing
Early diagnosis of severe combined immunodeficiency
Newborn Screening.Digital Access ClinicalKey [2023] - Printby John B. Harley, Sundaram V. Ramanan and Mabel M. Stevenson.
- DigitalLakshmi V. Srivaths, editor.Summary: Adolescent females experience a variety of blood disorders that are often unique to this patient population. As they go through puberty, they are uniquely poised to encounter various bleeding and thrombotic disorders once they attain menarche, start to have menstrual bleeding, and require hormonal therapy. This may in turn lead to other medical conditions, such as anemia and iron deficiency. Pregnancy encountered by some adolescents can pose hematologic challenges specifically in regards to bleeding and thrombotic disorders. In addition, adolescent females are at risk to develop immune mediated hematologic disorders, such as immune thrombocytopenia, auto-immune hemolytic anemia, and thrombotic thrombocytopenic purpura, as well as vitamin deficiencies due to pernicious anemia. Sickle cell disease, thalassemia and bone marrow failure disorders in the adolescent female poses unique challenges that need to be addressed with special care and attention. Knowledge about these various blood disorders in adolescent females is crucial for the treating physician in order to accurately diagnose and optimally manage these teenagers. Otherwise, it can affect their overall health, causing hematologic and gynecologic issues, poor quality of life, neurocognitive impairments, and poor psycho-social development, all of which can lead to various complications immediately and into adulthood. This book provides a comprehensive, state-of-the art overview of blood disorders in female adolescents. The text presents new data about bleeding disorders that affect the female adolescent, including bleeding disorders, thromboembolism, thrombophilia, anemia, sickle cell disease and thalassemia, disorders od hemostasis and thrombosis in pregnancy, immune hematology and bone marrow failure disorders; reviews our current understanding of these disorders; outlines recent research findings; and spotlights multi-disciplinary approaches, evaluation and treatment modalities to combat these blood disorders. Written by experts in the field, Hematology in the Adolescent Female is a valuable resource for clinicians and practitioners who treat and manage female adolescents with blood disorders.
Contents:
Evaluation Of the Adolescent with Heavy Menstrual Bleeding
Screening Tools for Evaluating the Bleeding Adolescent
Von Willebrand disease
Hemophilia Carriers
Rare Coagulation Factor Deficiencies
Platelet Disorders
Fibrinolytic Pathway Disorders
Hypermobility Syndromes in Heavy Menstrual Bleeding
Heavy Menstrual Bleeding Complications
Hormonal Therapy for Heavy Menstrual Bleeding
Hemostatic Therapy for Heavy Menstrual Bleeding
Quality of Life in Adolescents with Bleeding Disorders
Prevalence and Risk Factors Of Adolescent Thromboembolism
Management Of Adolescent Thromboembolism
Thrombophilia and Hormonal Therapy
Anticoagulation and Heavy Menstrual Bleeding
Iron Deficiency Anemia
Vitamin B12 Deficiency
Thalassemia Disorders
Sickle Cell Disease
Immune Thrombocytopenia Purpura
Autoimmune Hemolytic Anemia
Evan's Syndrome
Antiphospholipid Antibody Syndrome
Thrombotic Microangiopathies
Bone Marrow Failure Disorders
Adolescent Pregnancy and Blood Disorders.Digital Access Springer 2020 - DigitalMoshe C. Ornstein; Sudipto MurkhurjeeSummary: "Hematology-Oncology Board Review and Cases, a unique case-based content with multiple-choice questions, detailed explanations, and high yield pearls. This resource can also be used by the clinician daily to work through dosing and treatment options in preparation for administering care. All topics are covered on the ABIM's medical oncology board examination."-- Provided by publisher.Digital Access AccessHemOnc 2020
- DigitalJulie H. Rowe, Anneliese O. Gonzalez, Sayed H. Jafri, Putao Cen, Zeyad Kanaan, Robert J. Amato, Adan Rios, Hazem El Osta, Virginia Mohlere.Summary: The goal of Hematology-Oncology Clinical Questions is to empower clinicians to get their patients to the best solution as efficiently and effectively as possible. Each chapter provides a Key Concept section, which describes the basics of the question. The Clinical Scenario provides a clinical vignette in which these questions can be applied.
Contents:
Cancer pharmacology
Basics of oncology and pathology
Most common hematology questions
Screening
Breast cancer
Head and neck cancer
Gastrointestinal cancers
Genitourinary cancers
Gynecolological malignancies
Thoracic cancers
Rare cancers
Basics of bone marrow transplantation
Leukemia
Lymphoma
Plasma cell disorders
Myeloproliferative neoplasms
Myelodysplastic syndromes
Guidelines for supportive care
Oncologic emergencies
Genetic and familial assessment for hereditary cancer syndromes.Digital Access AccessHemOnc 2019 - Digital/PrintDigital AccessPrint Access
- Digital[edited by] Elaine S. Jaffe, Daniel A. Arber, Elias Campo, Nancy Lee Harris, Leticia Quintanilla-Martinez.Contents:
Processing of the lymph node biopsy specimen
Fine needle aspiration of lymph nodes
Collection, processing, and examination of bone marrow specimens
Immunohistochemistry for the hematopathology laboratory
Flow cytometry
Molecular diagnosis in hematopathology
Important chromosomal aberrations in hematologic neoplasms and key techniques to diagnose them
Normal lymphoid organs and tissues
Reactive lymphadenopathies
Normal bone marrow
Evaluation of anemia, leukopenia, and thrombocytopenia
Bone marrow findings in inflammatory, infectious, and metabolic disorders
Principles of classification of lymphoid neoplasms
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, monoclonal B-cell lymphocytosis, and B-cell prolymphocytic leukemia
Lymphoplasmacytic lymphoma and Waldenström macroglobulinemia
Hairy cell leukemia
Splenic marginal-zone lymphoma and other small B-cell neoplasms in the spleen
Follicular lymphoma
Extranodal marginal zone lymphoma : malt lymphoma
Primary cutaneous B-cell lymphomas
Nodal marginal zone lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma
Burkitt's lymphoma and its mimics
Plasmablastic neoplasms other than plasma cell myeloma
Plasma cell neoplasms
Nodular lymphocyte-predominant Hodgkin's lymphoma
Classical Hodgkin's lymphoma and related lesions
Virally associated B-cell lymphoproliferative disease
Virally associated T-cell and NK-cell neoplasms
T-cell and NK-cell large granular lymphocyte proliferations
T-cell prolymphocytic leukemia
Adult T-cell leukemia/lymphoma
Hepatosplenic T-cell lymphoma
Peripheral T-cell lymphoma, not otherwise specified
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, ALK positive and ALK negative
Enteropathy-associated T-cell lymphoma and other primary intestinal T-cell lymphomas
Mycosis fungoides and Sézary syndrome
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
Primary cutaneous T-cell lymphomas : rare subtypes
Precursor b- and T-cell neoplasms
Acute leukemias of ambiguous lineage
Principles of classification of myeloid neoplasms
Myelodysplastic syndromes
Acute myeloid leukemia
Myeloproliferative neoplasms
Myelodysplastic/myeloproliferative neoplasms
Mastocytosis
Eosinophilia and chronic eosinophilic leukemia, including myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 , OR JAK2
Blastic plasmacytoid dendritic cell neoplasm
Non-neoplastic histiocytic proliferations of lymph nodes and bone marrow
Histiocytic and dendritic cell neoplasms including Langerhans cell histiocytosis and Langerhans cell sarcoma
The pathology of primary immunodeficiencies
Iatrogenic immunodeficiency-associated lymphoproliferative disorders
Bone marrow evaluation for lymphoma
Evaluation of the bone marrow after therapy
Non-hematopoietic neoplasms of the bone marrow
Non-lymphoid lesions of the lymph nodes
Spleen : normal architecture and neoplastic and non-neoplastic lesions
Diagnosis of lymphoma in extranodal sites other than skin.Digital Access ClinicalKey 2017 - Digital[edited by] Eric D. Hsi.Contents:
Non-neoplastic disorders. Red blood cell/hemoglobin disorders
Coagulation
Non-neoplastic morphologic abnormalities of white blood cells and macrophages
Reactive lymph nodes and castleman disease
Bone marrow failure syndromes
Benign causes of bone marrow abnormalities including infections, storage diseases, systemic disorders, and stromal changes
Lymphomas
Small B-cell lymphomas
Diffuse aggressive B-cell lymphomas
Peripheral T-cell lymphomas
Immunodeficiency-related lymphoproliferative disorders
Hodgkin lymphoma
Leukemias, chronic myeloproliferative neoplasms, and myelodysplasia
B-cell leukemias of mature lymphocytes
Mature T-cell and natural killer cell leukemias
Acute myeloid leukemia
Precursor lymphoid neoplasms
Acute undifferentiated leukemia and mixed-phenotype acute leukemias
Myeloproliferative and "overlap" myelodysplastic/myeloproliferative neoplasms
Myelodysplastic syndromes
Disorders of histiocytes, mast cells, plasma cells, spleen, and ancillary techniques
Disorders of histiocytes
Mastocytosis
Multiple myeloma and other plasma cell neoplasms
Disorders of the spleen
Flow cytometric principles in hematopathology
Molecular diagnosis in hematopathologyDigital Access ClinicalKey 2018 - Digitaleditor: Thierry J. Molina.
- DigitalRenu Saxena, Hara Prasad Pati, editors.Summary: This book covers recent advances in the understanding and management of essential hematological pathologies. In addition to updates on Hodgkin's lymphoma, acute myeloid leukemia and other disorders, it provides essential information on transplant pathology, and the molecular and genetic aspects of hematological disorders. Offering a practical approach to lymphoma diagnosis, the book will help hematologists and pathologists alike make accurate diagnoses in keeping with the latest classifications and methodologies. A wealth of photographs and algorithms help readers understand the laboratory approach to the diagnosis of hematological disorders, reflecting the latest advances in the field. The book offers a valuable resource for residents of MD pathology, DM hematopathology and clinical hematology, as well as practitioners of hematology. -- Provided by publisher.Digital Access Springer 2019
- Digital[edited by] Franklin O. Smith, Gregory H. Reaman, Judy M. Racadio.Digital Access Springer 2014
- Digitaledited by editor-in-chief, Hillard M. Lazarus ; co-editors, Robert Peter Gale, Armand Keating, Andrea Bacigalupo, Reinhold Munker, Kerry Atkinson ; deputy editor, Syed Ali Abutalib.Summary: This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader with practice-changing advice. Full reference lists are also supplied to facilitate further exploration of each topic. Each copy of the printed book is packaged with a password, giving readers online access to all text and images. This inspiring resource demystifies both the basics and subtleties of hematopoietic cell transplantation, and is essential reading for both senior clinicians and trainees.Digital Access Cambridge 2017
- Digitaledited by Kevin D. Bunting and Cheng-Kui Qu, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA.Digital Access Springer 2014
- Digitaledited by Kim Schmit-Pokorny, Seth Eisenberg.Summary: "Hematopoietic stem cell transplantation (HSCT) has evolved from primary use in hematologic malignancies and nonmalignant disease and solid tumors into a treatment option for many other diseases, and indications for HSCT continue to expand. The new edition of this manual provides comprehensive information on the ever-evolving specialty of HSCT, providing nurses and other practitioners with in-depth information on the entire HSCT process, from stem cell mobilization, collection, and infusion to potential complications and long-term effects. It also includes chapters on current research, emerging therapies, ethics, HSCT program development, and professional practice issues"-- Provided by publisher.
Contents:
OVERVIEW OF HEMATOPOIESIS AND IMMUNOLOGY
BASIC CONCEPTS OF TRANSPLANTATION
CURRENT RESEARCH
CONSIDERATIONS IN PROGRAM DEVELOPMENT AND SITES OF CARE
STEM CELL COLLECTION
TRANSPLANT TREATMENT COURSE AND ACUTE COMPLICATIONS
ACUTE AND CHRONIC GRAFT-VERSUS-HOST DISEASE
HEMATOLOGIC EFFECTS
GASTROINTESTINAL COMPLICATIONS
HEPATORENAL AND BLADDER COMPLICATIONS
CARDIOPULMONARY COMPLICATIONS
NEUROLOGIC COMPLICATIONS
RELAPSE AND SUBSEQUENT MALIGNANCIES
LATE EFFECTS AND SURVIVORSHIP CARE
ETHICAL CONSIDERATIONS
EMERGING CELLULAR THERAPIES : CHIMERIC ANTIGEN RECEPTOR T CELLS
PROFESSIONAL PRACTICE.Digital Access R2Library 2020Limited to 1 simultaneous user - DigitalMenso J. Nubé, Muriel P.C. Grooteman, Peter J. Blankestijn, editors.Digital Access Springer 2016
- DigitalMichael R. Pinsky, Jean-Louis Teboul, Jean-Louis Vincent, editors.Summary: This book, part of the European Society of Intensive Care Medicine textbook series, teaches readers how to use hemodynamic monitoring, an essential skill for today's intensivists. It offers a valuable guide for beginners, as well as for experienced intensivists who want to hone their skills, helping both groups detect an inadequacy of perfusion and make the right choices to achieve the main goal of hemodynamic monitoring in the critically ill, i.e., to correctly assess the cardiovascular system and its response to tissue oxygen demands. The book is divided into distinguished sections: from physiology to pathophysiology; clinical assessment and measurements; and clinical practice achievements including techniques, the basic goals in clinical practice as well as the more appropriate hemodynamic therapy to be applied in different conditions. All chapters use a learning-oriented style, with practical examples, key points and take home messages, helping readers quickly absorb the content and, at the same time, apply what they have learned in the clinical setting. The European Society of Intensive Care Medicine has developed the Lessons from the ICU series with the vision of providing focused and state-of-the-art overviews of central topics in Intensive Care and optimal resources for clinicians working in Intensive Care.
Contents:
Introduction (Jukka Takala)
Part I. Physiology and Pathophysiology
Chapter 1. Shock: definition and recognition (Massimo Antonelli)
Chapter 2. Assessing the adequacy of cardiac output (Jean-Louis Vincent)
Chapter 3. The determinants of Venous Return (Maurizio Cecconi)
Chapter 4. Arterial blood Pressure Regulation (Michel Pinsky)
Chapter 5. Pulmonary Circulation (Marco Maggiorini)
Chapter 6. Heart Rate (Paul Marik)
Chapter 7. Autonomic Dysfunction in Shock (Gareth Ackland)
Chapter 8. Oxygen Delivery (Luciano Gattinoni)
Chapter 9. Mitochondrial Function (Mervyn Singer)
Chapter 10. Perioperative Hemodynamics (Andrew Rhodes)
Chapter 11. Haemodynamics and Extracorporeal Circulation (Alain Combes)
Part II. Clinical Assessment and Measurements
Chapter 12. Clinical Assessment of Hemodynamic Instability (Jan Bakker)
Chapter 13. Assessment of the microcirculation (Daniel De Backer)
Chapter 14. SvO2/ScVO2 (Zsolt Molnar)
^Chapter 15. pcO2 gap (Ospina-Tascon)
Chapter 16. Lactate (Glenn Hernandez)
Part III. The Techniques
Chapter 17. Cardiac Ultrasound Examination in Shock (Antoine Viellard Baron)
Chapter 18. Non Cardiac Ultrasound Signs in Shock (Paul Mayo)
Chapter 19. Central Venous Pressure (Sheldon Magder)
Chapter 20. Arterial Blood Pressure (Jean-Louis Teboul)
Chapter 21. Cardiac Output Monitors (Daniel Reuter)
Chapter 22. Volumetric Monitoring (Manu Malbrain)
Chapter 23. Assessment of Fluid Responsiveness (Xavier Monnet)
Chapter 24. Pulmonary Arterial Catheter (Didier Payen)
Chapter 25. Arterial Pressure Waveform Analysis Cardiac Output Monitoring (Ignacio Monge Garcia)
Chapter 26. Oesophageal Doppler (Monty Mythen)
Chapter 27. Bioimpedence / Bioreactance (Pierre Squara)
Chapter 28. Other Techniques (Jacques Duranteau)
Part IV. Basic Goals in Clinical Practice.-Chapter 29. Blood Pressure Targets in the initial stabilization (Pierre Asfar)
^Chapter 30. Choosing the right vasopressor (Anthony Gordon)
Chapter 31. Fluid Resuscitation (Anders Perner)
Part V. Choosing the Right Hemodynamic Therapy
Chapter 32. In Acute Heart Failure (Alexandre Mebazaa)
Chapter 33. In Septic Shock(Claude Martin)
Chapter 34. In ARDS (Luciano Gattinoni)
Chapter 35. In Neurological Emergencies (Fabio Taccone)
Chapter 36. For Perioperative Optimisation (Rupert Pearse)
Chapter 37. In a Patient under ECMO (Richard Beale). . - PrintMary E. Lough.Summary: "This comprehensive, evidence-based guide to hemodynamic monitoring procedures and patient care describes invasive, minimally invasive, and noninvasive techniques for monitoring blood pressure and oxygen levels within the circulatory system. Detailed comprehensive coverage is designed to fit the needs of today's critical care nurses and respiratory therapists."--Page [4] of cover.
Contents:
Part 1. Fundamentals of hemodynamic monitoring
1. Physiologic principles of hemodynamic monitoring
2. Physical assessment and hemodynamic monitoring
3. Arterial pressure monitoring
4. Central venous pressure monitoring
5. Pulmonary artery pressuer and thermodiluation cardiac output monitoring
6. Oxygenation and acid-base balance monitoring
7. Venous oxygen saturation monitoring
8. Capnography monitoring
9. Vasoactive medications
Part 2. Noninvasive and minimally invasive hemodynamic monitoring
10. Doppler hemodynamic monitoring
11. Ultrasonography-based hemodynamic monitoring
12. Arterial waveform and pressure based hemodynamic monitoring
13. Implantable hemodynamic monitoring
Part 3. Clinical applications of hemodynamic monitoring
14. Hemodynamics of mechanical ventilation and acute respiratory distress syndrome
15. Hemodynamics of mechanical circulatory support
16. Hemodynamic management following cardiac surgery
17. Hemodynamic management of heart failure and cardiogenic shock
18. Hemodynamics of acute right heart failure and pulmonary hypertension
19. Hemodynamic management in hypovolemia and trauma
20. Hemodynamics of sepsis
21. Hemodynamic and intracranial dynamic monitoring in neurocritical care
22. Goal-directed hemodynamics
Appendix
Index
Case studies and case examples. - DigitalRaphael Giraud, Karim Bendjelid.Contents:
Blood pressure
Monitoring of cardiac output and its derivatives
Hemodynamic monitoring techniques
Monitoring the adequacy of oxygen supply and demand
Echocardiography
Preload dependency dynamic indices
Perspectives. . - DigitalRose Knapp, DNP, RN, APRN-BC, Assistant Graduate Faculty, APN Program Coordinator, Monmouth University, Marjorie K. Unterberg School of Nursing and Health Studies, West Long Branch, NJ.Contents:
Cardiopulmonary anatomy and physiology / Maria Elsa Rodriguez
Understanding a pressure monitoring system / Natalie Burkhalter
Vascular access / Susan Barnason
Arterial pressure monitoring / PatricIa Walters
Central venous pressure monitoring / Kathleen M. Hill
Pulmonary artery pressure monitoring / Margaret Mcatee
Cardiac output monitoring / Julene B. (Julie) Kruithof
Tissue oxygenation monitoring / Michelle D. Staggs
Minimally invasive hemodynamic monitoring / Loisann Stapleton
Circulatory assist devices / Nancy M. Richards.Digital Access Ovid 2016 - Digitalclinical editor, Rose Knapp.Summary: Build a solid knowledge base in hemodynamic nursing skills, with the newly updated "Hemodynamic Monitoring Made Incredibly Visual!, 4th Edition". Full of colorful images that illustrate monitoring concepts and processes, this concise, enjoyable guide sorts through the complexities of hemodynamics and clarifies them in easy-to-follow ways. Grasp the structures and functions of pulmonary and cardiac systems and the vital skills of hemodynamics, with this vital reference -- a must-have for all nursing students, new nurses, and nurses returning to critical care. -- From product description.
Contents:
Cardiopulmonary anatomy and physiology / Erica Sciarra
Understanding a pressure monitoring system / Natalie Burkhalter
Vascular access / Susan Barnason
Arterial pressure monitoring / Patricia Walters
Central venous pressure monitoring / Kathleen M. Hill
Pulmonary artery pressure monitoring / Margaret McAtee
Cardiac output monitoring / Julene B. (Julie) Kruithof
Tissue oxygenation monitoring / Michelle D. Staggs
Minimally invasive hemodynamic monitoring / Loisann Stapleton
Circulatory assist devices / Anna Remy.Digital Access Ovid 2020 - Digitaledited by Morton J. Kern, Michael J. Lim, James A. Goldstein.Summary: "The essential resource on cardiac hemodynamics--now in a new edition Hemodynamic Rounds, Fourth Edition is intended to help cardiologists, cardiovascular fellowship trainees, residents and other members of the medical community enhance their understanding of cardiac physiology and its associated hemodynamic presentations in health and disease. This includes the basic principles of flow and pressure measurements, systemic as well as coronary hemodynamics in normal and diseased states, and changes in hemodynamics following interventional procedures ranging from TAVI and valvuloplasty to stent placement. Like its popular predecessors, this new edition draws on case studies to illustrate characteristic cardiac hemodynamic findings and discusses the essential methods used in interpreting pressure waveforms as a diagnostic and monitoring tool. The text is organized into chapters on specific areas of the heart, common cardiac pathophysiologic conditions, and hemodynamic situations resulting from different therapeutic procedures. It includes discussions of both normal and abnormal pressure waveforms. This new edition has been revised throughout to include brand new content on aortic and mitral valve stenosis and regurgitation as well as TAVI and mitral clip hemodynamics. Highlights include: Essential and easy to understand resource for those required to interpret cardiac blood flow and blood pressure tracings Covers hemodynamic assessment by cardiac disorder, plus the bedside applications of hemodynamics Revised throughout and includes brand new content on valve stenosis and regurgitation and TAVI and mitral clip hemodynamics Hemodynamic Rounds: Interpretation of Cardiac Pathophysiology from Pressure Waveform Analysis, Fourth Edition is an indispensable tool for all physicians, nurses, and students responsible for measuring and interpreting cardiac waveforms in cardiac diagnosis and monitoring"--Provided by publisher.Digital Access Wiley 2018
- DigitalGila Perk.Summary: The book provides a practically focused review of the latest techniques used for hemodynamic assessment in the echocardiography laboratory. It features a methodical case-based approach covering how to measure hemodynamic parameters successfully, including stroke volume, valve area and regurgitation severity, in a range of scenarios of varying complexity. Step-by-step guidance on how to apply the techniques described are provided. Each chapter also contains didactic features to assist the reader in assimilating the key points in every case, assisting them to develop their knowledge of how to treat patients with both routine and complex hemodynamic issues in the echocardiography laboratory. Hemodynamics in the Echocardiography Laboratory therefore represents a concise resource on how to carry out hemodynamic assessments and is a valuable resource for trainees and fellows in cardiology and echocardiography seeking a concise review of the topic.
Contents:
Intro
Contents
1: General Principles
1.1 Doppler Principle
1.2 Bernoulli Principle
1.2.1 Bernoulli Equation (Fig. 1.2)
1.3 Wiggers Diagram
1.4 Summary and Final Points
2: Math in the Echo Lab
2.1 Volume Calculations
2.1.1 VTI-Based Technique
2.1.2 Border Tracing-Based Technique
2.2 Resistance Calculations
2.3 Continuity Principle
2.4 PISA (Proximal Isovelocity Surface Area) Calculation
2.5 Volumetirc Calculations
2.6 Summary and Final Points
3: Pulmonary Pressure: Beginner
3.1 Pulmonary Artery Systolic Pressure 3.2 Analyzing TR Spectral Doppler Envelope
3.3 Measuring Peak TR Velocity
3.4 Assessing Right Atrial Pressure
3.5 Interpreting the Data
3.6 Summary and Final Points
4: Pulmonary Pressure: Advanced
4.1 Pulmonary Artery Diastolic Pressure
4.2 Mean Pulmonary Artery Pressure
4.2.1 Calculating Mean PAP Based on Sys/Dias PAP
4.2.2 PI Early Diastolic Velocity
4.2.3 TR VTI
4.2.4 PA Acceleration Time
4.3 Pulmonary Vascular Resistance
4.3.1 Comparing TR [delta]P and RVOT Flow
4.3.2 Calculating Pressure Drop and Flow across Pulmonary Circulation 4.4 Summary and Final Points
5: How Severe Is This MR
5.1 General Principles
5.2 Anatomic/Color Assessment for EROA
5.2.1 3D-Based Direct Measurement of EROA
5.2.2 Vena Contracta Measurement
5.3 PISA Method
5.3.1 Pointers and Potential Pitfalls for the PISA Method
5.4 Color Doppler Assessment
5.5 Volumetric Calculations
5.6 Summary and Final Points
6: What Is Wrong with This MR: Part I
6.1 Case Presentation
6.2 Approach to an Unusual MR Tracing
6.3 Summary and Final Points
7: What's Wrong with This MR: Part II
7.1 Case Presentation 7.2 Approach to an Unusual MR Tracing
7.2.1 Low Peak Velocity
7.2.2 Abnormal MR Envelope Shape
7.3 Summary and Final Points
8: Why Is This Happening Now
8.1 First-Degree Heart Block
8.1.1 Approach to Abnormal MR Timing
8.2 High Degree Heart Block
8.2.1 Approach to Abnormal MR Timing
8.3 The Missing Atrial Contraction
8.3.1 Approach to Abnormal MR Timing
8.4 Summary and Final Points
9: Extreme Pulsus Alternans
9.1 Case Presentation
9.2 Summary and Final Points
10: Is This AI an Emergency
10.1 AI Quantification
10.2 AI Hemodynamics 10.3 Summary and Final Points
11: There's a Hole in the Heart: Part I
11.1 Approach to ASD Evaluation
11.2 Case Presentation
11.2.1 Anatomic Type of ASD
11.2.2 Shunt Direction
11.2.3 Magnitude of the Interatrial Shunt
11.2.4 Effect of the Shunt on Chamber Size and Function
11.2.5 Presence of Pulmonary Hypertension
11.2.6 Estimation of Pulmonary Vascular Resistance
11.3 Case Presentation
11.3.1 Shunt Direction
11.3.2 Magnitude of the Interatrial Shunt
11.3.3 Effect of the Shunt on Chamber Size and Function - Digitaledited by Thomas Ming Swi Chang, McGill University, Canada, Yoshihiro Endo, Shiga University of Medical Science, Japan, Volodymyr G. Nikolaev, Ukrainian Academy of Sciences, Ukraine, Tohru Tani, Shiga University of Medical Science, Japan, Yaoting Yu, Nankai University, China, Wen-Hui Zheng.Digital Access World Scientific 2017
- DigitalDavid Green.Summary: Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles.Digital Access ScienceDirect 2018
- Digitaleditors, Bernard R. Bendok, MD William J. and Charles H. Mayo Professor and Chair of Neurological Surgery Mayo Clinic Phoenix, Arizona, USA H. Hunt Batjer, MD Professor Emeritus and Past Chair Department of Neurological Surgery University of Texas Southwestern Medical Center Dallas, Texas, USA Associate Editors Brian W. Chong Bart M. Demaerschalk Chandan Krishna Devi P. Patra Rudy J. Rahme Ayan Sen Evelyn L. Turcotte Andrej Urumov Mathew E. Welz.Summary: "In the last decade, advances in interventional, microsurgcial, radiosurgical techniques, medical approaches and imaging technology have dramatically changed the management of ischemic stroke. Perhaps the most important advance has been the increasing collaboration between multispecialty clinicians to deliver team-based stroke care. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical, and Interventional Approaches, Second Edition by renowned neurosurgeons Bernard R. Bendok and H. Hunt Batjer and acclaimed contributors provides a user-friendly, single resource for managing ischemic and hemorrhagic stroke. The second edition has been updated to reflect progress, most notably acute evaluation and triage, advanced imaging, critical care and medical support, and endovascular and surgical interventions. In addition to scientifically supported content, readers will benefit from pragmatic, real-world applications and concise, practical reviews. Organized into four sections and 41 chapters, the text starts with the section Acute Triage, which includes early diagnosis and medical decision-making, advances in medical imaging, innovations in prehospital management of stroke, and the promise of telestroke networks. The second section, Critical Care, covers the importance of astute clinical examination, stabilization, and advanced neuromonitoring techniques. The third section, Open Surgical, Minimally Invasive, and Microsurgical Approaches, reviews recent surgical innovations that have the potential to be lifesaving and enhance quality of life in select patients. The fourth and final section, Neurointerventional Approaches, explores recent innovations in image-guided catheter techniques to deliver new therapies for stroke treatment and prevention"-- Provided by publisher.
Contents:
Clinical presentation and acute triage of ischemic stroke, intracranial hemorrhage, and subarachnoid hemorrhage / Devi P. Patra, Onur Açiş, Miles Hudson, Benzion Blech, Gyanendra Kumar, Vanesa K. Vanderhye, Lynda M. Christel, and Bernard R. BendokDigital Access Thieme MedOne Neurosurgery [2024], c2025 - DigitalEdoardo Boccardi, Marco Cenzato, Francesco Curto, Marco Longoni, Cristina Motto, Valentina Oppo, Valentina Perini, Simone Vidale.Summary: This book provides detailed practical guidance on the management of hemorrhagic stroke in the clinical settings encountered in daily practice. Real-life cases are used to depict a wide range of clinical scenarios and to highlight significant aspects of management of hemorrhagic stroke. In addition, diagnostic and therapeutic protocols are presented and helpful decision-making algorithms are provided that are specific to the different professionals involved in delivery of stroke care and to differing types of hospital facility. The coverage is completed by the inclusion of up-to-date scientific background information relevant to diagnosis and therapy. Throughout, the approach adopted is both practical and multidisciplinary. The book will be of value for all practitioners involved in the provision of stroke care, and also for medical students.
Contents:
Diagnosis and therapy in the acute phase of hemorrhagic stroke: latest developments
Clinical cases
Clinical organizational pathways for hemorrhagic stroke
Differentiated decisional algorithms.Digital Access Springer 2017 - DigitalHyung Kyu Yang.Summary: This book provides up-to-date knowledge on hemorrhoids for proctologists. It covers all aspects, including the history of hemorrhoids, the anatomy of the anal canal, pathophysiology, diagnosis, and treatment. Both conservative treatment approaches and surgical methods are explained with the aid of numerous high-quality illustrations and schematic drawings. Particular attention is paid to lift-up submucosal hemorrhoidectomy, developed by the author by modifying Parks' original method. Additionally, other important techniques proposed by world leaders in the field are described and illustrated. The international trend towards use of day-case hemorrhoidectomy is acknowledged by considering this approach in detail, with discussion of patient preparation, anesthesia, surgical technique, and postoperative management. The treatment of hemorrhoids in a variety of special circumstances is examined, including new trends in PPH. The closing chapter is devoted to the various forms of anesthesia for anal surgery.
- Digitaledited by Carlo Ratto, Angelo Parello, Francesco Litta.Summary: This book offers a comprehensive guide to hemorrhoidal disease, the most frequent coloproctological affection. In addition to amply illustrated chapters covering the epidemiology and anatomic, physiologic, and pathophysiologic bases of hemorrhoids, readers will find helpful information on the classification of hemorrhoidal disease and modalities to assess it, as well as their significant impact on the choice of treatment. The work presents a complete panel of all therapies usually adopted to treat this condition and their outcomes, which are critically commented on by prominent specialists. Further, management of the disease in special conditions is also discussed. Lastly, a literature review and evaluation of the impact of different treatments on the patient's quality of life round out the volume, which is part of the Reference Work series entitled Coloproctology.
Contents:
Section 1- Basics on hemorrhoids: 1 Epidemiology of hemorrhoidal disease
2 Anatomy, physiology and pathophysiology of hemorrhoids
3 Classification of hemorrhoidal disease and impact on the choice of treatment
4 Haemorrhoids and media: impact on the patients
5 Clinical assessment of hemorrhoidal disease. Section 2- Therapeutic approach to the hemorrhoidal disease: 6 Medical therapy of hemorrhoidal disease
7 Endoscopic treatment of internal hemorrhoids
8 Selection of patients to the surgical treatment of hemorrhoids
9 Critical aspects of modern surgical approach to hemorrhoids
10 Management of hemorrhoidal disease in special conditions
11 The acute management of hemorrhoids. Section 3- Outpatient treatments: 12 Rubber band ligation, Sclerotherapy, Infrared coagulation and others: techniques and results in the surgical treatment of hemorrhoids
13 Why and when I do prefer outpatient treatments in the surgical treatment of hemorrhoids
14 Technical tips and tricks of outpatients treatments for hemorrhoids
15 Pros and contras of outpatients treatments for hemorrhoids
16 Main advantages of outpatients treatments for hemorrhoids
17 Main disadvantages of outpatients treatments for hemorrhoids
18 Literature review on outpatients treatments for hemorrhoids. Section 4- Hemorrhoidectomy: 19 Traditional hemorrhoidectomy: techniques and results
20 Modern hemorrhoidectomy: techniques and results
21 Why and when I do prefer the hemorrhoidectomy
22 Technical tips and tricks of hemorrhoidectomy
23 Pros and contras of hemorrhoidectomy
24 Main advantages of hemorrhoidectomy
25 Main disadvantages of hemorrhoidectomy
26 Literature review on hemorrhoidectomy. Section 5- Stapled hemorrhoidopexy: 27 Stapled hemorrhoidopexy: techniques and results
28 Why and when I do prefer the stapled haemorrhoidopexy
29 Technical tips and tricks of stapled haemorrhoidopexy
30 Pros and contras of stapled haemorrhoidopexy
31 Main advantages of stapled haemorrhoidopexy
32 Main disadvantages of stapled haemorrhoidopexy
33 Literature review on stapled haemorrhoidopexy. Section 5- Hemorrhoidal dearterialization and mucopexy: 34 Dearterialization of hemorrhoids and mucopexy: techniques and results
35 Hemorrhoidal dearterialization with laser: techniques and results
36 Why and when I do prefer the dearterialization of hemorrhoids and mucopexy
37 Technical tips and tricks of dearterialization of hemorrhoids and mucopexy
38 Pros and contras of dearterialization of hemorrhoids and mucopexy
39 Main advantages of dearterialization of hemorrhoids and mucopexy
40 Main disadvantages of dearterialization of hemorrhoids and mucopexy
41 Literature review on dearterialization of hemorrhoids and mucopexy. Section 6 -Perioperative management and outcome: 42 Intra- and postoperative management in patients submitted to operation for hemorrhoids
43 Postoperative complications following surgical procedures for hemorrhoids and their management
44 Literature data on the hemorrhoidal disease management
45 Patients' quality of life after different treatments for hemorrhoidal disease. . - DigitalThomas G. DeLoughery, editor.Summary: The latest edition of this practical handbook provides a concise yet comprehensive overview of common and rare problems with hemostasis and thrombosis. Through thoroughly updated and revised chapters, the text features practical information on diagnosing and managing troublesome hematologic conditions often found in clinical practice. The handbook also spotlights advances in the field since the publication of the last edition, including multiple novel coagulation factors for hemophilia, the increasing use of novel anticoagulants and their reversal agents, and the increasing use of genetics for diagnosis. Written by experts in the field, Hemostasis and Thrombosis, Fourth Edition is an invaluable resource for healthcare professionals who treat patients afflicted with these conditions. -- Provided by publisher.
Contents:
Basics of Coagulation
Tests of Hemostasis and Thrombosis
Bleeding Disorders: A General Approach
Hemophilia
von Willebrand Disease
Other Inherited Bleeding Disorders
Acquired Bleeding Disorders
Disseminated Intravascular Coagulation
Liver and Renal Disease
Cardiac Bypass and Ventricular Assist Devices/ECMO
Immune Thrombocytopenia
Thrombotic Microangiopathy (TTP/HUS)
Non-Blood Product Agents for Bleeding Disorders
Transfusion Therapy and Massive Transfusions
Deep Venous Thrombosis and Pulmonary Embolism
Thrombosis in Unusual Sites
Inherited Thrombophilias
Aquired Thrombophilias
Antiphospholipid Antibody Syndrome
Antithrombotic Therapy for Cardiac Disease
Stroke and Peripheral Vascular Disease
Heparins and Heparin-Induced Thrombocytopenia
Other Parenteral Anticoagulants
Direct Oral Anticoagulants
Warfarin
Antiplatelet Agents
Thrombolytic Therapy
Clinical Dilemmas In Anticoagulation: Extremes Of Weight, Renal Disease, Recent Bleeding, And Surgery
Bleeding and Thrombosis in Cancer Patients
Hemostasis and Thrombosis in Pregnancy
Hemorrhage and Thrombosis in Women
Pediatric Thrombosis.Digital Access Springer 2019 - Digitaledited by Hussain I. Saba, Harold R. Roberts.Contents:
Theories of blood coagulation : basic concepts and recent updates / Dougald M. Monroe, Maureane Hoffman
Vascular endothelium, influence on hemostasis : past and present / Hussain I. Saba, Sabiha R. Saba
Coagulation testing : basic and advanced clinical laboratory tests for the diagnosis of common hemostatic and thrombotic disorders / Nils Egberg and Margareta Blombäck
Hemophilia A (factor VIII deficiency) : clinical bleeding and management / Pier Mannuccio Mannucci and Massimo Franchini
Hemophilia B (factor IX deficiency) : clinical manifestations and management / R. S. Kasthuri, H. R. Roberts, P. E. Monahan
Factor XI deficiency (hemophilia C) / Charles E. Bane, Anne T. Neff, and David Gailani
Factor VIII and IX inhibitors in hemophilia / Meera Chitlur and Jeanne Lusher
Treatment options for acquired hemophilia / Anjali Sharathkumar and David Green
Factor XII deficiency (Hageman factor deficiency) / Evi Stavrou and Alvin H. Schmaier
Inherited combined factor deficiency states / Asma Latif and Louis Aledort
Acute and chronic ITP : biology, diagnosis, and management / Samir Dalia and Benjamin Djulbegovic
Disseminated intravascular coagulation (DIC) : diagnosis and management / Stephanie J. Davis, Craig M. Kessler
Mechanisms of fibrinolysis and basic principles of management / John W. Weisel and I. Litvinov
Post thrombotic syndrome / Jean-Philippe Galanaud, Susan R. Kahn
Von Willebrand disease : clinical aspects and practical management / Francesco Rodeghiero, Alberto Tosetto, Giancarlo Castaman
Platelets in hemostasis : inherited and acquired qualitative disorders / Noman Ashraf and Hussain I. Saba
Contributions of platelet polyphosphate to hemostasis and thrombosis / James H. Morrissey
Thrombotic microangiopathy : thrombotic thrombocytopenic purpura and hemolytic uremic syndrome : biology, diagnosis, and management / Samir Dalia
Hemostasis and aging / Lodovico Balducci
Hemostatic problems in chronic and acute liver disease / Ton Lisman and Robert J. Porte
Cancer and thrombosis / Erica Peterson and Agnes Lee
An update on low-molecular-weight heparins / Jawed Fareed, Debra Hoppensteadt, Walter P. Jeske.Digital Access Wiley 2014 - DigitalRichard P. Szumita, Paul M. Szumita, editors.Summary: "This book offers a thorough, clinically oriented review of hemostasis and its impact on the practice of dentistry. Readers will gain a sound understanding of the pathophysiology of hemostasis and the pharmacology of antithrombotic and prothrombotic medications. Perioperative dental management strategies of value in patients with different congenital and acquired disorders of hemostasis are carefully explained, and the role of surgical techniques and local and topical agents in helping to minimize and control bleeding is described. Helpful instruction is also provided on the indications for antithrombotic medications and the management of patients receiving such therapy, including the risks of altering medications. As the number of available oral antithrombotic agents continues to increase, dentists will encounter significantly more patients receiving treatments that affect hemostasis. In presenting comprehensive, up-to-date information on hemostasis, hemostatic disorders, antithrombotic therapy, and safe dental management, this book will serve as a rich source of information and a useful guide for practitioners and students alike."-- Provided by publisher.
- DigitalTodd Pawlicki, Daniel J. Scanderbeg, George Starkschall.Contents:
Atomic structure and radioactive decay
Interactions of X rays and gamma rays
Interactions of particulate radiation with matter
Machines for producting radiation
Measurement of ionizing radiation
Calibration of megavoltage beams of X rays and electrons
Central-axis point dose calculations
External beam dose calculations
External beam treatment planning and delivery
The basics of medical imaging
Diagnostic imaging and applications to radiation therapy
Tumor targeting: image-guided and adaptive radiation therapy
Computer systems
Radiation oncology informatics
Physics of proton radiation therapy
Sources for implant therapy and dose calculation
Brachytherapy treatment planning
Radiation protection
Quality assurance
Patient safety and quality improvement.Digital Access Wiley 2016 - Digitaledited by Edgar V. Lerma, MD, FACP, FASN, FNKF, Clinical Professor of Medicine, Section of Nephrology, University of Illinois at Chicago/Advocate Christ Medical Center, Oak Lawn, Illinois, Associates in Nephrology, Chicago, Illinois, Matthew R. Weir, MD, Professor and Director, Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.Contents:
Sect. I: Technical and procedural considerations in hemodialysis
Sect. II: Technical and procedural considerations in peritoneal dialysis
Sect. III: Clinical considerations in the evaluation of dialysis patients
Sect. IV: Drugs and intoxications
Sect. V: Dialysis in the pediatric population
Sect. VI: Dialysis in specific circumstances
Sect. VII: Business of dialysis.Digital Access Ovid 2017 - PrintAccess via Bulletin of the history of medicine 1939-
- Digital[edited by] Richard A. McPherson, Matthew R. Pincus.Summary: "This twenty-fourth edition marks more than 100 years since A Manual of Clinical Diagnosis, authored by James Campbell Todd, was introduced in 1908. In its current format as Henry's Clinical Diagnosis and Management by Laboratory Methods, this textbook remains the authoritative source of information for residents, students, and other trainees in the disciplines of clinical pathology and laboratory medicine, and for physicians and laboratory practitioners. The current edition continues the tradition of partnership between laboratory examinations and the formulation and confirmation of clinical diagnoses followed by monitoring of body functions, therapeutic drug levels, other results of medical treatments, and risk assessment for disease"--Publisher's description.
Contents:
Part 1: The clinical laboratory. General concepts and administrative issues
Optimizing laboratory workflow and performance
Preanalysis
Analysis: principles of instrumentation
Mass spectrometry and applications
Analysis: clinical laboratory automation
Point-of-care testing and physician office laboratories
Postanalysis: medical decision making
Interpreting laboratory results
Laboratory statistics
Quality control
Clinical laboratory informatics
Financial management
Ethics in laboratory medicine
Part 2: Clinical chemistry. Evaluation of renal function, water , electrolytes and acid-base function
Biochemical markers of bone metabolism
Carbohydrates
Lipids and dyslipoproteinemia
Cardiac injury, atherosclerosis, and thrombotic disease
Specific proteins
Clinical enzymology
Evaluation of liver function
Laboratory diagnosis of gastrointestinal and pancreatic disorders
Toxicology and therapeutic drug monitoring
Evaluation of endocrine function
Reproductive function and pregnancy
Vitamins and trace elements
Chemical basis for analyte assays and common interferences
Part 3: Urine and other body fluids. Basic examination of urine
Cerebrospinal, synovial, serous body fluids, and alternative specimens
Part 4: Hematology and transfusion medicine. Basic examination of blood and bone marrow
Hematopoiesis
Erythrocytic disorders
Leukocytic disorders
The flow cytometric evaluation for hematopoietic neoplasia
Immunohematology
Transfusion medicine
Hemapheresis
Tissue banking and progenitor cells
Part 5: Hemostasis and thrombosis. Coagulation and fibrinolysis
Platelet disorders and von willebrand disease
Laboratory approach to thrombotic risk
Antithrombotic therapy
Part 6: Immunology and immunopathology. Overview of the immune system and immunologic disorders
Immunoassays and immunochemistry
Laboratory evaluation of the cellular immune system
Laboratory evaluation of immunoglobulin function and humoral immunity
Mediators of inflammation: complement
Mediators of inflammation: cytokines and adhesion molecules
Human leukocyte antigen: the major histocompatibility complex of man
The major histocompatibility complex and disease
Immunodeficiency disorders
Clinical and laboratory evaluation of systemic autoimmune rheumatic diseases
Vasculitis
Organ-specific autoimmune diseases
Allergic diseases
Part 7: Medical microbiology. Medical bacteriology
In vitro testing of antimicrobial agents
Mycobacteria
Mycotic diseases
Spirochete infections
Chlamydial and mycoplasmal infections
Rickettsiae and other related intracellular bacteria
Viral infections
Medical parasitology
Specimen collection and handling for diagnosis of infectious diseases
Part 8: Molecular pathology. Introduction to molecular pathology
Molecular diagnostics: basic principles and techniques
Polymerase chain reaction and other nucleic acid amplification technology
Hybridization array technologies
Applications of cytogenetics in modern pathology
Molecular diagnosis of genetic diseases
Molecular genetics of neuro-psychiatric disorders: current research and perspectives
Identity testing: use of DNA analysis in parentage, forensic, and missing persons testing
Pharmacogenomics and personalized medicine
Part 9: Clinical pathology of cancer. Diagnosis and management of cancer using serologic and other body fluid markers
Oncoproteins and early tumor detection
Molecular diagnosis of hematopoietic neoplasms
Molecular genetic pathology of solid tumors
High-throughput genomic and proteomic technologies in the post-genomic era
Appendices. Physiologic solutions, buffers, acid-base indicators, standard reference materials, and temperature conversions
Desirable weights, body surface area, and body mass index
Approximations of total blood volume
Periodic table of elements
Si units
Common chimeric genes identified in human malignancies
Disease/organ panels.Digital Access ClinicalKey 2022 - Digitaleditors, Glenn P. Gravlee, MD (Professor and Vice Chair for Faculty Affairs, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado), Andrew D. Shaw, MB, FRCA (Professor and Chair, Department of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada), Karsten Bartels, MD, MS (Assistant Professor of Anesthesiology, Medicine and Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado).Summary: "The title of the sixth edition has changed to "Hensley's Practical Approach to Cardiothoracic Anesthesia" to honor Rick Hensley (see Dedication) and to acknowledge the incorporation of noncardiac thoracic anesthesia topics, which was actually done in previous editions without titular recognition. This edition also adds 19 links to video clips spread across Chapters 11, 12, and 19. In addition to the Key Points at the beginning of each chapter, all chapters now include several Clinical Pearls, which are short, key clinical concepts located in the text section where their subject matter is presented. Highlighting of key references constitutes another new feature"-- Provided by publisher.Digital Access
- DigitalIsrael Vlodavsky, Ralph D. Sanderson, Neta Ilan, editors.Summary: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase's multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
Contents:
Intro
Contents
Contributors
About the Editors
Part I: Historical and General Background
Chapter 1: Forty Years of Basic and Translational Heparanase Research
1.1 Historical Introduction
1.1.1 Key Observations Made Prior to Cloning of the HPSE Gene (Chronological Order)
1.2 Heparanase Gene Cloning
1.3 Studies Performed Following Cloning of the HPSE Gene
1.3.1 Introductory Notes
1.3.2 Key Observations Made After Cloning of the HPSE Gene
Structural Aspects
Gene Regulation
Angiogenesis & Metastasis
Animal Models Heparanase Uptake and Cellular Traffic
Nuclear Heparanase and Its Transcriptional Activity
Heparanase Non-Enzymatic and Signaling Function
Heparanase Inhibitors
Various Tumors
Multiple Myeloma
Tumor Microenvironment
Inflammation and Cells of the Immune System
Vaccination
Diabetes, Diabetic Complications and Other Disorders
Aterosclerosis & Thrombosis
Viral Infection
1.4 Concluding Remarks and Perspectives
References
Chapter 2: Heparanase - Discovery and Targets
2.1 Introduction
2.2 Heparanase, Early Findings 2.3 Stereochemistry of Heparanase Target
2.4 How Many Heparanases?
2.5 Heparanase and Polysaccharide Metabolism
2.6 Heparanase and the GAGosome
References
Chapter 3: Heparanase: Historical Aspects and Future Perspectives
3.1 Introduction
3.2 Historical Overview and General Properties of Heparanase
3.3 Overview of Substrate Specificity of Heparanase
3.4 Functions Dependent on Heparanase Enzymatic Activity
3.4.1 HS Turnover
3.4.2 Involvement in Cell Invasion
3.4.3 Involvement in Release of ECM Bound Proteins 3.4.4 Involvement in Depletion of Intracellular Anti-Oxidant Stores of HS
3.4.5 Facilitator of Spread of HS-Binding Viruses
3.4.6 Inhibitors of Heparanase Enzymatic Activity
3.5 Functions Independent of Heparanase Enzymatic Activity
3.5.1 Cell Adhesion Molecule
3.5.2 Promoter of Signal Transduction
3.5.3 Transcription Factor
3.6 Future Perspectives
3.6.1 How Does Heparanase Initiate Signalling Pathways?
3.6.2 Do Nuclear Heparanase and HS Interact?
3.6.3 Relationship Between Heparanase-1 and Heparanase-2
3.6.4 Drug Development: Where to Next? 3.7 Concluding Remarks
References
Chapter 4: Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation
4.1 Introduction
4.1.1 The Syndecan Family of Heparan Sulfate Proteoglycans
4.1.2 Heparanase - A Key Enzyme in ECM Remodeling
4.2 The Heparanase-Syndecan Axis
4.2.1 Heparanase Mediated Sdc1 Shedding
4.2.2 Heparanase and Sdc1 in the Nucleus
4.2.3 Effects on Exosome Formation and Function
4.2.4 Effects on Growth Factor Signaling
4.3 Functional Cooperation of Syndecan-1 and Heparanase in Inflammation
4.3.1 Lessons from Mouse Models Role of Sdc1 and Heparanase in Delayed-Type Hypersensitivity - DigitalRahul Nanchal, Ram Subramanian, editors.Summary: This book focuses on the critical care of the patient with acute, acute on chronic and chronic liver failure as well as the peri-operative care of the patient with liver transplantation. Each of these disease processes is unique in pathophysiological manifestations, underpinnings of physiology and treatment options. Patients with acute, chronic or acute on chronic liver failure are a growing fraction of ICU admissions. Hepatic Critical Care serves as the essential reference for both practicing intensivists at community hospitals and tertiary referral centers. This textbook is also targeted towards trainees specifically interested in taking care of patients with liver disease and liver transplantation.
Contents:
Normal Hepatic Function and Physiology
Circulatory Physiology in Liver Disease
Respiratory Physiology in Liver Disease
Gastrointestinal and Hepatic Physiology in Liver Disease
Renal Physiology in Acute and Chronic Liver Disease
Cerebrovascular Physiology in Liver Disease
Definition, Epidemiology, Natural History and Prognostication of Liver Disease
Brain and the Liver- Cerebral Edema, Hepatic Encephalopathy and Beyond
Cardiovascular Alterations in Acute and Chronic Liver Failure
Gastrointestinal Complications in Liver Disease
Respiratory Complications in Acute and Chronic Liver Disease
Renal Complications in Acute and Chronic Liver Disease
Hematological Complications in Liver Disease
Nutrition in Liver Disease
Infectious Complications in Liver Disease
Pharmacological Considerations in Liver Failure
Non Transplant Surgical Considerations: Hepatic Surgery and Liver Trauma
Anesthetic and Perioperative Considerations in the patient with liver disease (Non Transplant)
Perioperative Considerations during Liver Transplantation
Use of Extra-Corporeal Liver Support Therapies
Assessing Liver Function in the Critically Ill Patient. - DigitalJia-Horng Kao, Ding-Shinn Chen, editors.Summary: This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection.
- DigitalJia-Horng Kao, editor.Summary: This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, novel biomarkers, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments for possible functional cure of HBV infection. In this second edition, authors provides recent updates in epidemiology, biomarkers, antivirus therapy, and novel therapy for functional cure of chronic hepatitis B virus infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection.
- DigitalYun-Fan Liaw, Fabien Zoulim.Contents:
HBV Virology and Replication
Experimental Models: Cell Culture and Animal Models
Hepatitis B Virus Genotypes
HBV Immunopathogenesis
Carcinogenesis
Hepatitis B Virus: Persistence and Clearance
HDV Virology and Replication
Translational Medicine in HBV?What Can We Learn from Clinical Samples?
Global Epidemiology of HBV Infection
Clinical Virology: Diagnosis and Virologic Monitoring
Natural History of Hepatitis B Virus Infection
Natural History of HBV Infection in the Community
Occult HBV Infection
The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance and Novel Small Molecule Inhibitors
IFN-Based Therapy and Management of Patients
Nucleoside Analogue-Based Therapy and Management of Patients (Including HIV Co-infections, HBV and Pregnancy)
Organ Transplantation in HBV Infected Patients
Reactivation of Hepatitis B Virus Due to Cancer Chemotherapy and Other Immunosuppressive Drug Therapy
Immunoprophylaxis of Hepatitis B Virus Infection and Its Sequelae
Towards HBV Eradication. - DigitalHong Tang, editor.Summary: This volume provides a state-of-the-art review of the key aspects of HBV. It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV. It also provides an update on cell and animal models, as well as molecular approaches. The respective chapters also cover the clinical management of hepatitis B and discuss future research directions, in particular, the identification of molecular targets for pharmacological intervention. Given its scope, the book offers a valuable resource for students, researchers, clinicians, and health practitioners in the fields of virology, infectious disease, public health etc. Dr Hong Tang is a Professor and Director of the Center of Infectious Diseases, West China Hospital of Sichuan University.
Contents:
Intro; Preface; Contents;
Chapter 1: Hepatitis B Virus Infection: Overview; 1 Discovery of HBV; 2 Epidemiology and Natural History of HBV Infection; 3 Biological Characteristics and Immunopathogenesis of HBV; 3.1 HBV Genome and Life Cycle; 3.2 HBV Transcription and Translation; 3.3 Immunopathogenesis of HBV; 4 Current Antiviral Drugs Against HBV and New Antiviral Drugs Under Development; 4.1 Current Antiviral Drugs Against HBV; 4.2 Optimization Treatment Strategies Based on Current Antiviral Drugs; 4.3 Advances in the Development of New Anti-HBV Drugs 4.3.1 Direct Antiviral Drugs Against the Life Cycle of HBV4.3.2 Indirect Antiviral Drugs that Modulate Host Immune Response to Control CHB; References;
Chapter 2: HBV Genome and Life Cycle; 1 Introduction; 2 HBV Genome; 3 Viral Entry; 4 The Conversion of rcDNA to cccDNA; 5 The Expressions of Viral RNAs and Proteins; 6 Viral Capsid Assembly, Reverse Transcription, and rcDNA Formation; 7 Viral Budding; 8 Conclusion; References;
Chapter 3: The Regulation of HBV Transcription and Replication; 1 Introduction; 2 Transcription of the HBV Genome 3 Cis-Acting Transcriptional Regulatory Sequence Elements and Trans-Acting DNA-Binding Proteins4 Role of Liver-Enriched Transcription Factors in HBV Transcription, Replication, and Tissue Tropism; 5 Redundant Functions for Nuclear Receptors in HBV Biosynthesis; 6 Regulation of HBV Biosynthesis by Transcriptional Coactivators and Corepressors; 7 Transcriptional Regulation of HBV Replication In Vivo; 8 Conclusions; References;
Chapter 4: Immunopathogenesis of HBV Infection; 1 Introduction; 2 Viral Factors Leading to HBV Persistence; 2.1 HBV Genetic Variants 2.2 Impact of Viral Load on HBV Persistence3 Host Genetics; 4 Innate Immune Responses; 4.1 HBV Recognition by Innate Sensors; 4.2 HBV-Driven Inhibition of Innate-Signaling Pathways; 4.3 NK Cells; 4.4 Liver Macrophages; 4.5 MDSC; 4.6 NKT; 4.7 MAIT; 5 Adaptive Immune Responses; 5.1 Antigen-Presenting Cells; 5.2 CD4+ T Cells; 5.3 CD8+ T Cells; 5.4 B Cells; 6 Liver Injury in HBV Infection; 6.1 HBV-Induced ER and Mitochondrial Dysfunctions; 6.2 HBV Surface Antigen Mutations in Fulminant Hepatitis B and Occult HBV Infection 6.3 HBV RNAs Deregulate miRNA Functions Leading to Pathological Consequences6.4 HBV X Protein Interferes with the Apoptosis Signaling to Promote Viral Proliferation and HCC Progression; 7 Immune-Tolerant Phase of HBV Infection; 8 Age-Dependent Immune Response to HBV Infection; 9 Maternal Effect on HBV Persistence: Induction of Trained Immunity in Human Neonates of HBV+ Mothers; 10 Conclusions; References;
Chapter 5: Cell Culture Models and Animal Models for HBV Study; 1 Introduction; 2 HBV Cell Culture Models; 2.1 HBV DNA Integrated Stable Cell Models; 2.2 HBV Infection Cell Models 2.3 HBV Recombinant cccDNA Transfection Cell ModelsDigital Access Springer 2020 - Digitaledited by Sanaa M. Kamal.Contents:
Hepatitis C virus / Ahmed Abdel Aziz
Epidemiology and modes of transmission of HCV in developing countries / Sanaa M. Kamal and Dahlia Ghoraba
Public health and economic burden of Hepatitis C infection in developing countries / Tamer A. Hafez
Social, cultural, and political factors influencing HCV in developing countries / Sara A. Abdelhakam and Mohamad A. Othman
Hepatitis C in Egypt / Sanaa M. Kamal and Sara A. Abdelhakam
Hepatitis C in North Africa (Arabic Maghreb region) / Mohamed A. Daw
Hepatitis C virus in sub-saharan Africa / Osi Obadahn and Sanaa M. Kamal
Hepatitis C virus infection in the Indian sub-continent / Shashi Shekhar
Hepatitis C in developing countries in southeast Asia / Thi Q. Doan
Hepatitis C and schistosomisasis coinfection / Sanaa M. Kamal
Hepatitis C and Helminthic infections / Khalifa S. Khalifa and Othman Amin
Hepatitis C and HIV coinfection in developing countries / Ozlem Tastan Bishop
Hepatiis B and C coinfection / Georgios Zacharakis
Hepatitis C infection in patients with hemogloinopathies / Sanaa M.Kamal and Ahmed M. Fouad
Hepatitis C in patients on hemodialysis / Tamer A. Hafez
Hepatitis C screening and diagnosis in developing countries / Huda H. Gaafar
Hepatitis C treatment in the era of direct-acting antiviral agents / Sanaa M. Kamal.Digital Access ScienceDirect 2018 - DigitalMarina Berenguer, editor.Summary: Hepatitis C Virus and Liver Transplantation is designed to provide a comprehensive and state-of-the-art overview of the major issues specific to the field of liver transplantation and hepatitis C virus infection. The sections of the book have been structured to review the overall scope of issues of recurrent hepatitis C in different complex settings, including retransplantation, HIV-coinfected patients or in the setting of suboptimal graft donors. This book provides up-to-date information on the application of new therapies to the field of liver transplantation. It provides the most recent data on their efficacy, the management of side effects, as well as the potential interactions and specific problems associated with their use in the transplant setting. Finally, an appraisal of the risks and benefits of using organs from anti-HCV positive donors is presented.
Contents:
1. Treatment of Hepatitis C Before Liver Transplantation
2. Donor-Recipient Matching in HCV-Infected Patients
3. Natural History of Recurrent Hepatitis C: Impact of Immunosuppression
4. Treatment of Hepatitis C After Liver Transplantation
5. Hepatitis C and Liver Transplantation in the HIV Co-Infected Patients
6. Liver Transplantation for Hepatocellular Carcinoma in HCV-Infected Patients
7. Retransplantation for HCV-Related Liver Disease
8. Use of Anti-HCV Positive Grafts in Liver Transplantation. - DigitalTatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita, editors.Contents:
Natural history of chronic Hepatitis C
The multifaceted features of HCV infection beyond the liver
Hepatic fibrosis in Hepatitis C Virus
HCV, alcohol, and the liver
Extrahepatic replication of HCV
Hepatitis C virus infecction in pregnancy and childhood
Host genetics and responses to antiviral therapy in chronic Hepatitis C
Viral variation and response to therapy
HCV NS3/4A protease inhibitors and the road to effective direct-acting antiviral therapies
Mechanism of action of direct-acting antivirals: new insights into HCV life cycle
Modeling HCV dynamics in clinical practice to personalize antiviral therapy
Prophylactic vaccines for the Hepatitis C virus
Global control of hepatitis C virus infection
Index.Digital Access Springer 2016 - DigitalKazuaki Chayama, editor.Summary: This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.Digital Access Springer 2017
- Digital/PrintYouchun Wang, editor.Contents:
Hepatitis E virus / Youchun Wang, Chenyan Zhao, Ying Qi, Yansheng Geng-- Characteristics and functions of HEV proteins / Yan Zhou, Chenyan Zhao, Yabin Tian, Nan Xu [and others]
Epidemiology of hepatitis E / Yansheng Geng, Youchun Wang
Hepatitis E as a zoonosis / Frederik Widén,-- Genetic evolution of hepatitis E virus / Yulin Zhangcandidate, Wanyun Gong, Hang Zeng, Ling Wang-- Transmission of hepatitis E virus / Yansheng Geng, Youchun Wang
Immunobiology and host response to HEV / Yihua Zhou
HEV cell culture / Feng Zhang, Youchun Wang
Animal Models for Hepatitis E Virus / Lin Wangcandidate, Ling Wang-- Clinical Manifestations of Hepatitis E / Shaojie Xin, Long Xiao
Laboratory diagnosis of HEV infection / Chenyan Zhao, Youchun Wang
Treatment of hepatitis E / Wei Hui, Linlin Wei, Zhuo Li, Xinhui Guo
Prophylactic hepatitis E vaccine / Jun Zhang., Qinjian Zhao, Ningshao Xia.Digital Access Springer 2016 - DigitalCataldo Doria, Jason N. Rogart, editors.Summary: Hepato-Pancreato-Biliary cancers are increasing in incidence, with pancreatic cancer now accounting for the third most cancer deaths in the United States. Typically these malignancies, as a group, are managed by the same key providers comprising a multidisciplinary team. This book is intended to provide a comprehensive review of the current knowledge in the field of hepato-pancreato-biliary malignancies, focusing on the practical and clinical care of patients. We take the approach of combining the collective expertise of an interventional gastroenterologist and a hepato-pancreato-biliary surgeon to provide the readers with accurate, succinct, and pragmatic information needed to formulate the most appropriate treatment plan for their patients with the aim of the best possible outcome. Managing patients with these cancers continues to be challenging because of continued dismal survival rates. Each section in this text is written by experts in their respective field, summarizing the most state-of-the-art, contemporary diagnostic and therapeutic tools available in the field. We believe this book will prove to be an invaluable, comprehensive resource for all members of the multidisciplinary team caring for patients with hepato-pancreato-biliary malignancies.
Contents:
Approach to the patient with a solid liver mass
Pathogenesis, Epidemiology and Prognosis of Hepatocellular carcinoma (HCC)
HCC Pathology
Diagnosis and Evaluation of HCC
Liver-directed therapy (IR) for HCC
Medical Management of HCC
Surgical Management of HCC
Treatment of liver metastasis from colorectal cancer
Treatment of isolated liver metastasis from non-colorectal cancer
Pathogenesis, Epidemiology and Prognosis of Uncommon Liver Tumors
Diagnosis and Management of Uncommon Liver Tumors
Reducing the Risk of and Screening for Liver Cancer
Pathogenesis, Epidemiology and Prognosis of Cholangiocarcinoma
Pathology of Cholangiocarcinoma
Diagnosis and Evaluation of Cholangiocarcinoma
Nonsurgical Management of Cholangiocarcinoma
Surgical Management of Cholangiocarcinoma
How do I approach Klatskin’s tumor
Endoscopic Palliative Management of Cholangiocarcinoma
Rare Tumors of the Bile Ducts: Pathogenesis, Epidemiology, Diagnosis, and Management
Pathogenesis, Epidemiology and Prognosis of Gallbladder Cancer
Diagnosis and Evaluation of Gallbladder Cancer
Pathology of Gallbladder Cancer
Nonsurgical Management of Gallbladder Cancer
Surgical Management of Gallbladder Cancer
Approach to the Patient with a Pancreatic Mass
Evaluation and Management of the Patient with a Pancreatic Cyst
Pathogenesis, Epidemiology and Prognosis of Pancreatic Adenocarcinoma
Diagnosis and Evaluation of Pancreatic Adenocarcinoma
Pathology of Pancreatic Adenocarcinoma
Nonsurgical management of Pancreatic Adenocarcinoma,- Surgical management of Pancreatic Adenocarcinoma
Intra-operative radiation treatment
Endoscopic Palliative Management of Pancreatic Adenocarcinoma
Reducing the Risk of and Screening for Pancreatic Cancer
Pathogenesis, Epidemiology and Prognosis of Pancreatic Neuroendocrine Tumors
Pathology of Pancreatic Neuroendocrine Tumors
Diagnosis and Evaluation of Pancreatic Neuroendocrine Tumors
Nonsurgical management of Pancreatic Neuroendocrine Tumors
Surgical Management of Pancreatic Neuroendocrine Tumors
Emerging endoscopic therapies for Pancreatic Neuroendocrine Tumors
Pathogenesis and Pathology of Rare Pancreatic Neoplasms
Diagnosis and Management of Rare Pancreatic Neoplasms
Molecular and Genetic Profiling for Diagnosis and Therapy of Hepatobiliary and Pancreatic Malignancies
The Role of Robotic Surgery in Treating Hepatobiliary and Pancreatic Malignancies
The Importance of the Multidisciplinary Approach to Managing Hepatobiliary and Pancreatic Malignancies
The Role of the Palliative Care Team in the Management of Hepatobiliary and Pancreatic Malignancies
The Role of Alternative Medicine in the Management of Hepatobiliary and Pancreatic Malignancies
Integrative Medicine and Hepatobiliary and Pancreatic Cancer: What to Expect
Is Personalized Medicine Truly Making a Difference for Patients Diagnosed with Cancers of the Liver, Biliary Tract, and Pancreas. - Digitaledited by Keith D. Lillemoe, William R. Jarnagin.Contents:
I: Pancrease and biliary tract
II: Liver.Digital Access Ovid 2020 - DigitalHepatobiliary and Pancreatic Surgery : a Companion to Specialist Surgical Practice. Seventh edition.edited by Rowan W. Parks, Stephen J. Wigmore.Digital Access ClinicalKey 2024
- Digitaleditors: J. Charles Jennette, Vivette D. D'Agati ; associate editors: Agnes B. Fogo, Volker Nickeleit, M. Barry StokesSummary: "Heptinstall's Pathology of the Kidney (HPK) eighth edition has undergone more extensive updating compared to any prior edition to showcase recent astounding advances in all aspects of kidney disease. This comprehensive text maintains the excellence established by Robert H. Heptinstall, who edited and to a considerable degree authored the first four editions of this classic text first published in 1966. Since the publication of the seventh edition in 2015, there have been extraordinary advances in the understanding of the cellular, molecular, and genetic basis for kidney diseases; in the knowledge of pathologic and clinical manifestations of kidney diseases; and in the utilization of pathologic findings for directing new and more precise treatment of kidney diseases. This eighth edition has been thoroughly updated to include in-depth reviews of important new advances that ave clarified understanding, redirected research on mechanisms, made diagnosis of pathologic lesion more precise, and improved the treatment and prevention of kidney diseases"-- Provided by publisher
Contents:
Kidney pathology history and kidney biopsy methods / J. Charles Jennette, Vivette D. D'Agati, Agnes B. Fogo, Volker Nickeleit, and M. Barry Stokes
Primer on the pathologic classification and diagnosis of kidney disease / J. Charles Jennette, Vivette D. D'Agati, Agnes B. Fogo, and Volker Nickeleit, M. Barry Stokes
Kidney anatomy and histology / William L. Clapp
Kidney development / Filipa M. Lopes & Adrian S. Woolf
Patterns of injury, terminology and classification of kidney congenital anomalies and cystic diseases / Helen Liapis & J. Charles Jennette
Congenital anomalies including dysplasia / Helen Liapis, Sanjay Jain & Bharathi V. Reddy
Cystic kidney disease / Helen Liapis & Bharathi V. Reddy
Patterns of injury, terminology and classification of glomerular diseases associated with proteinuria and nephrotic syndrome / Vivette D. D'Agati & J. Charles Jennette
Minimal change disease / M. Barry Stokes
Focal segmental glomerulosclerosis / Vivette D. D'Agati & M. Barry Stokes
Membranous nephropathy / Glen S. Markowitz, Sanjeev Sethi & Vivette D. D'Agati
Amyloidosis / Maria M. Picken & Guillermo A. Herrera
Monoclonal immunoglobulin-related glomerular disease / Sanjeev Sethi, Fernando C. Fervenza & Samih H. Nasr
Immunotactoid glomerulopathy / Samih H. Nasr, Fernando C. Fervenza & Sanjeev Sethi
Diabetic kidney disease / Behzad Najafian & Charles E. Alpers
Idiopathic nodular glomerulosclerosis / M. Barry Stokes & Vivette D. D'Agati
Metabolic and storage disease glomerulopathies / Laura S. Finn
Fibronectin glomerulopathy / Megan Troxell & Neeraja Kambham
Collagenofibrotic glomerulopathy and nail patella syndrome / Laura S. Finn & Agnes B. Fogo
Patterns of injury, terminology and classification of glomerular diseases associated with hematuria and nephritic syndrome / J. Charles Jennette & Vivette D. D'Agati
IgA nephropathy and IgA vasculitis (Henoch-Schönlein purpura) nephritis / Mark Haas
Lupus nephritis and related autoimmune diseases / Vivette D. D'Agati & M. Barry Stokes
Fibrillary glomerulonephritis / Kelly D. Smith
Cryoglobulinemic glomerulonephritis / Ian W. Gibson & Volker Nickeleit
Acute postinfectious glomerulonephritis and infection-associated glomerulonephritis / Anjali A. Satoskar & Tibor Nadasdy
C3 glomerulopathy / H. Terence Cook & Matthew C. Pickering
Anti-glomerular basement membrane disease / J. Charles Jennette & Ingeborg M. Bajema
Anti-neutrophil cytoplasmic autoantibody disease / J. Charles Jennette & Ingeborg M. Bajema
Alport syndrome/type IV collagen nephropathies / Agnes B. Fogo
Patterns of injury, terminology and classification of kidney vasculopathies / M. Barry Stokes & J. Charles Jennette
Kidney disease related to hypertension and age / Agnes B. Fogo
Fibromuscular dysplasia / Surya V. Seshan & J. Charles Jennette
Thrombotic microangiopathies / Kerstin Amann & Agnes B. Fogo
Preeclampsia and other pregnancy associated kidney disease / Agnes B. Fogo
Disseminated intravascular coagulation / Kerstin Amann & Agnes B. Fogo
Atherosclerosis and embolic kidney disease / Hans-Joachim Anders & Agnes B. Fogo
Polyarteritis nodosa, Kawasaki disease, Takayasu arteritis, and giant cell arteritis / Surya V. Seshan & J. Charles Jennette
Patterns of injury, terminology and classification of tubulointerstitial disease / Agnes B. Fogo & J. Charles Jennette
Infection-related tubulointerstitial nephritis / Megan Troxell & Neeraja Kambham
Noninfectious tubulointerstitial nephritis / Cynthia C. Nast & Agnes B. Fogo
IgG4-related disease / Lynn D. Cornell
Chronic interstitial nephritis in agricultural communities (mesoamerican nephropathy, CKDu) and aristolochic acid nephropathy (Balkan endemic nephropathy) / Cynthia C. Nast & Marc E. De Broe
Nephronophthisis, medullary cystic disease, and other genetic tubular disease / Laura S. Finn
Ischemic and septic acute tubular injury and cortical necrosis / Joseph P. Gaut
Nephrotoxic acute tubular injury / Gilbert W. Moeckel
Light chain tubulopathies / M. Barry Stokes
Light chain (myeloma) cast nephropathy and mimics / Virginie Royal & Guillermo A. Herrera
Myoglobin, hemoglobin, and bile cast nephropathies, and anti-coagulant nephropathy / Joseph P. Gaut, Sergey V. Brodsky & Tibor Nadasdy
Nephrolithiasis and crystallopathies / Laura S. Finn & Hans-Joachim Anders
Obstructive and reflux nephropathy / Lois J. Arend
Patterns of injury, terminology and classification of kidney transplant disease / Volker Nickeleit & J. Charles Jennette
Kidney allograft biopsy : overview / Volker Nickeleit
Donor kidney biopsies / Harsharan K. Singh & Volker Nickeleit
Kidney transplant rejection / Volker Nickeleit, Robert B. Colvin & Peter Nickerson
Kidney transplant ischemic injury / Parmjeet Randhawa
Kidney transplant : drug toxicity / Volker Nickeleit & Parmjeet Randhawa
Kidney transplant infection / Harsharan K. Singh & Volker Nickeleit
Recurrent and de novo disease / Parmjeet Randhawa & Volker Nickeleit
Posttransplant lymphoproliferative disorder / Parmjeet Randhawa & Volker Nickeleit
Kidney transplant : surgical and vascular complications / Parmjeet Randhawa & Volker Nickeleit
Patterns of injury, terminology and classification of kidney neoplasms / John N. Eble, Liang Cheng & J. Charles Jennette
Kidney neoplasms in children / John N. Eble & Liang Cheng
Kidney neoplasms in adults / John N. Eble & Liang ChengDigital Access LWW Health Library [2024] - DigitalD'Agati, Vivette D.; Heptinstall, Robert H.; Jennette, J. Charles; Olson, Jean L.; Silva, Fred G.Contents:
Renal anatomy and histology / Stephen M. Bonsib
Development of the kidney / Adrian S. Woolf and Dagan Jenkins
Primer on the pathologic classification and diagnosis of renal disease / J. Charles Jennette, Fred G. Silva, Jean L. Olson, and Vivette D. Dagati
Cystic diseases and developmental kidney defects / Helen Liapis and Paul Winyard
The nephrotic syndrome and minimal change disease / Jean L. Olson
Focal segmental glomerulosclerosis and childhood nephrotic syndrome / Vivette D. DAgati and M. Barry Stokes
Membranous glomerulonephritis / Glen S. Markowitz and Vivette D. DAgati
Membranoproliferative glomerulonephritis / Xin J. Zhou and Fred G. Silva
C3 glomerulopathies, including dense deposit disease / H. Terence Cook and Matthew C. Pickering
Acute postinfectious glomerulonephritis and glomerulonephritis caused by persistent bacterial infection / Anjali A. Satoskar, Tibor Nadasdy, and Fred G. Silva
Renal injury associated with human immunodeficiency virus infection and therapy / Arthur H. Cohen and Cynthia C. Nast
Iga nephropathy and iga vasculitis (henoch-schonlein purpura) nephritis / Mark Haas
Alports syndrome, familial benign hematuria, nail-patella syndrome, type iii collagen glomerulopathy, and piersons syndrome / Marie-Claire Gubler, Laurence Heidet, and Corinne Antignac
Renal disease in systemic lupus erythematosus, mixed connective tissue disease, sjögren's syndrome, and rheumatoid arthritis / Vivette D. D'Agati and M. Barry Stokes
Anti-glomerular basement membrane glomerulonephritis and goodpasture's syndrome / J. Charles Jennette and Volker Nickeleit
Pauci-immune and antineutrophil cytoplasmic autoantibodymediated crescentic glomerulonephritis and vasculitis / J. Charles Jennette and David B. Thomas
Volume 2
Renal involvement in polyarteritis nodosa, kawasaki disease, takayasu arteritis, and giant cell arteritis / J. Charles Jennette and Harsharan K. Singh
Thrombotic microangiopathies / Zoltan G. Laszik, Neeraja Kambham, and Fred G. Silva
Renal disease in pregnancy / Agnes B. Fogo
Renal disease caused by hypertension / Jean L. Olson
Diabetic nephropathy / Jean L. Olson and Zoltan G. Laszik
Renal diseases associated with plasma cell dyscrasias, amyloidoses, and waldenström's macroglobulinemia / Guillermo A. Herrera and Maria M. Picken
Glomerular diseases with organized deposits / Samy S. Iskandar and Guillermo A. Herrera
Pyelonephritis, reflux nephropathy, hydronephrosis, and nephrolithiasis / Helen Liapis, Joseph P. Gaut, John E. Tomaszewski, and Lois Arend
Acute and chronic tubulointerstitial nephritis / Sergey V. Brodsky and Tibor Nadasdy
Ischemic and toxic acute tubular injury and other ischemic renal injury / Gilbert Moeckel, Michael Kashgarian, and Lorraine V. Racusen
Renal disease caused by inborn errors of metabolism, storage diseases, and hemoglobinopathies / Laura S. Finn
Renal changes with aging and end-stage renal disease / Xin J. Zhou, Andrew Fenves, Nosratola D. Vaziri, and Ramesh Saxena
Renal transplant pathology / Volker Nickeleit, Michael Mengel, and Robert B. Colvin
Renal neoplasms / John N. Eble and David J. Grignon.Digital Access Ovid 2015 - DigitalSaikat Sen, Raja Chakraborty, editors.Summary: This book highlights the medical importance of and increasing global interest in herbal medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements, herbal cosmetics, etc. It also addresses various issues that are hampering the advancement of Indian herbal medicine around the globe; these include quality concerns and quality control, pharmacovigilance, scientific investigation and validation, IPR and biopiracy, and the challenge that various indigenous systems of medicine are at risk of being lost. The book also explores the role of traditional medicine in providing new functional leads and modern approaches that can offer elegant strategies for facilitating the drug discovery process. The book also provides in-depth information on various traditional medicinal systems in India and discusses their medical importance. India has a very long history of safely using many herbal drugs. Folk medicine is also a key source of medical knowledge and plays a vital role in maintaining health in rural and remote areas. Despite its importance, this form of medicine largely remains under-investigated. Out of all the traditional medicinal systems used worldwide, Indian traditional medicine holds a unique position, as it has continued to deliver healthcare throughout the Asian subcontinent since ancient times. In addition, traditional medicine has been used to derive advanced techniques and investigate many modern drugs. Given the scope of its coverage, the book offers a valuable resource for scientists and researchers exploring traditional and herbal medicine, as well as graduate students in courses on traditional medicine, herbal medicine and pharmacy.
- DigitalBhupendra Koul.Summary: This book provides detailed information on the various types of cancer, etiology, effects, and challenges associated with current cancer treatment regimes. The present edition has been written to reflect recent developments, success rates and lacunae in herbal and modern cancer therapies. It also describes the use of several herbal formulations to boost patients' immunity, in order to prevent or help them cope with several cancers. The book highlights several herbs/shrubs/trees that have been reported to possess anti-cancer properties, paving the way for in-depth research into the dose standardization and efficacy of plant-based bioactive molecules. It also focuses on the sustainable conservation of medicinal flora, so that, in future, novel biomolecules be extracted and made available for the treatment of various cancers. Given its highly relevant content, the book will benefit the entire cancer research community (students, scientists, pharmacists, herbalists and lecturers) at universities, research institutions and industry in the areas of oncology, herbal cancer therapy, biotechnology, drug discovery, pharmaceuticals, agriculture, and various disciplines of the biomedical sciences.
Contents:
Module 1. Foreword
Module 2. Preface
Module 3. Abbreviations
Module 4. General introduction
Module 5. Types of cancers
Module 6. Cancer treatment and their side effects
Module 7. Molecular basis of cancer
Module 8. Ayurvedic concepts of cancer
Module 9. Plants with anti-cancer potential
Module 10. Psychological therapy in cancer treatment. - PrintR. Eric Thomas.Summary: "R. Eric Thomas didn't know he was different until the world told him so. Everywhere he went--whether it was his rich, mostly white, suburban high school, his conservative black church, or his Ivy League college in a big city--he found himself on the outside looking in. In essays by turns hysterical and heartfelt, Eric redefines what it means to be an "other" through the lens of his own life experience. He explores the two worlds of his childhood: the barren urban landscape where his parents' house was an anomalous bright spot, and the verdant school they sent him to in white suburbia. He writes about struggling to reconcile his Christian identity with his sexuality, about the exhaustion of code-switching in college, accidentally getting famous on the internet (for the wrong reason), and the surreal experience of covering the 2016 election as well as the seismic change that came thereafter. Ultimately, Eric seeks the answer to the ever more relevant question: Is the future worth it? Why do we bother when everything seems to be getting worse? As the world continues to shift in unpredictable ways, Eric finds the answers to these questions by re-envisioning what "normal" means, and in the powerful alchemy that occurs when you at last place yourself at the center of your own story"-- Provided by publisher.
Contents:
Introduction: The Monster at the End of This Book
The Audacity
There's Never Any Trouble Here in Bubbleland
Molly, Urine Danger Girl
She's Got Herself a Universe
Historically Black
Disorientation
Someone Is Wrong on the Internet
Unsuccessful Black Hair
Flames, at the Side of My Face
Ball So Soft
Fate Bursting through the Wall
Krampromise
Comforters
The Preacher's Husband
Dinner Guests
Eggquity
The Past Smelled Terrible
Unsubscribe from All That
Here for It, or How to Save Your Soul in America
Epilogue: The End Is Coming Running about Fifteen Minutes Late. - DigitalSeigo Nakamura, Daisuke Aoki, Yoshio Miki, editors.Summary: This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.
Contents:
1 History, Advancements, and Future Strategies
2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis
3 Genetic Testing
4 Variants of uncertain significances in hereditary breast and ovarian cancer
5 Genetic counseling in Hereditary Breast and Ovarian Cancer
6 Hereditary Breast Cancer
7 Hereditary Ovarian Cancer
8 Risk-Based Breast Cancer Screening
9 Chemoprevention for Breast Cancer
10 Chemoprevention for Ovarian Cancer
11 Risk-Reducing Mastectomy (RRM)
12 Risk-reducing salpingo-oophorectomy (RRSO)
13 Panel Testing
14 Germline Findings through Precision Oncology for Ovarian Cancer
15 Germline Findings from Genetic Testing for Breast Cancer
16 Hereditary Breast and Ovarian Cancer (HBOC) Database
17 Ethical Issues: Overview in Genomic analysis and Clinical Context
18 PARP Inhibitors-Mechanism of action
19 PARPi - Efficacy in Hereditary Breast Cancer
20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer. - DigitalGemmy Cheung, editor.Summary: This volume of the retina atlas focuses on hereditary chorioretinal disorders. The topics covered include retinitis pigmentosa, Best disease, congenital X-linked retinoschisis, cone dystrophy, Stargardt's disease, pattern dystrophy, North Carolina macular dystrophy, choroideremia, Mallattia Leventinese, Bietti's crystalline dystrophy, and albinism. All clinical features are clearly illustrated with multimodal imaging techniques. The utility of some of the latest imaging tools such as OCT angiography, adaptive optics-scanning laser ophthalmoscopy, and microperimetery is discussed. Readers will gain valuable new insights into pathogenesis at the molecular level, which have been facilitated by recent genetic discoveries. The use of genetic testing and the latest advances in and challenges of gene therapy and cell-based therapy are also covered in detail. Hereditary Chorioretinal Disorders atlas is one of nine volumes in the series Retina Atlas. The series provides validated and comprehensive information on vitreoretinal diseases, covering imaging basics, retinal vascular diseases, macular disorders, ocular inflammatory and infectious disorders, retinal degeneration, the surgical retina, ocular oncology, pediatric retina and trauma.
Contents:
Retinits pigmentosa and allied disorders
Best's disease
Congenital X-linked retinoschisis
Progressive cone dystrophy and cone-rod dystrophy
Pattern dystrophy of the retinal pigment epithelium
Stargardt's disease and fundus flavimaculatus
North Carolina macular dystrophy
Choroideremia
Malattia Leventinese or Doyne honeycomb retinal dystrophy
Bietti's crystalline dystrophy
Albinism.Digital Access Springer 2020 - DigitalLaura Valle, Stephen B. Gruber, Gabriel Capellá, editors.Summary: This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Contents:
Part1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome
The molecular basis of Lynch-like syndrome
Constitutional mismatch repair deficiency
Mismatch repair proficient hereditary non-polyposis colorectal cancer
Genetic and environmental modifiers of risk in Lynch syndrome
ADENOMATOUS POLYPOSIS SYNDROMES- Introduction
Familial adenomatous polyposis
Polymerase proofreading-associated polyposis
MUTYH-associated polyposis
NTHL1-associated polyposis
Germline biallelic inactivation of MMR genes (with polyposis phenotype)
Unexplained adenomatous polyposis
HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome
Juvenile polyposis syndrome
PTEN-hamartoma tumor syndromes
Other hamartomatous polyposis conditions
HEREDITARY MIXED POLYPOSIS SYNDROME
SERRATED POLYPOSIS SYNDROME
Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT
Genetic testing in hereditary colorectal cancer
Universal tumor screening for Lynch syndrome
Classification of genetic variants. Prediction models for Lynch syndrome
Surveillance guidelines for hereditary colorectal cancer syndromes
Surgical management of hereditary colorectal cancer syndromes
Chemoprevention in hereditary colorectal cancer syndromes
Immunotherapy in hereditary colorectal cancer
The Immune Biology of Microsatellite Unstable cancer
Hereditary colorectal cancer: Immunotherapy approaches
Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES
Databases: intentions, capabilities and limitations
The Colon Cancer Family Registry Cohort
The Prospective Lynch Syndrome Database
The InSiGHT Database: An example LOVD system
The International Mismatch Repair Consortium. - DigitalRobert M. Tanguay, editor.Summary: "Hereditary tyrosinemia type 1 (HT1), the most severe inborn error of the tyrosine degradation pathway, is due to a deficiency in fumarylacetoacetate hydrolase (FAH). The worldwide frequency of HT1 is one per 100,000 births, but some regions have a significantly higher incidence (1:1,800). The FAH defect results in the accumulation of toxic metabolites, mainly in the liver. If left untreated, HT1 is usually fatal before the age of two. HT1 patients develop several chronic complications including cirrhosis with a high risk of hepatocellular carcinoma (HCC) and neuropsychological impairment. Treatment comprises an inhibitor of the pathway, Nitisinone, a strict dietary treatment or liver transplantation. Early treatment is important to avoid HCC. The book includes the latest developments on the molecular basis of HT1, its pathology, screening and diagnosis and management of the disease written by leading scientists, geneticists, hepatologists and clinicians in the field"--Publisher's description.
Contents:
Hereditary tyrosinemia type I. Discovery of hereditary tyrosinemia in Saguenay- Lac St-Jean / Jean Larochelle
Biochemical and clinical aspects of hereditary tyrosinemia type 1 / Geneviève Morrow, Robert M. Tanguay
Molecular basis of HT1. Molecular aspects of the FAH mutations involved in HT1 disease / Geneviève Morrow, Francesca Angileri, Robert M. Tanguay
Molecular pathogenesis of liver injury in hereditary tyrosinemia 1 / Robert M. Tanguay, Francesca Angileri, Arndt Vogel
Pathology. Tyrosinemia and liver transplantation: experience at CHU Sainte-Justine / Fernando Alvarez, Grant A. Mitchell
The liver in tyrosinemia type I: clinical management and course in Quebec / Ugur Halac, Josée Dubois, Grant A. Mitchell
Liver transplantation for hereditary tyrosinaemia type 1 in the United Kingdom / Patrick McKiernan
NTBC and correction of renal dysfunction / Arianna Maiorana, Carlo Dionisi-Vici
Liver cancer in tyrosinemia type 1 / Willem G. van Ginkel, Jan P. Pennings, Francjan J. van Spronsen
Neurological and neuropsychological problems in tyrosinemia type I patients / Willem G. van Ginkel, Rianne Jahja, Stephan C.J. Huijbregts, Francjan J. van Spronsen
Screening. Diagnosing hepatorenal tyrosinaemia in Europe: newborn mass screening versus selective screening / Anibh M. Das, Sebene Mayorandan, Nils Janzen
Tyrosinemia type I in Japan: a report of five cases / Kimitoshi Nakamura, Michinori Ito, Yosuke Shigematsu, Fumio Endo
Newborn screening for hereditary tyrosinemia type I in Québec: update / Yves Giguère, Marie-Thérèse Berthier
Hepatorenal tyrosinemia in Mexico: a call to action / Isabel Ibarra-González, Cecilia Ridaura-Sanz, Cynthia Fernández-Lainez [and others]
Hereditary tyrosinemia type 1 in Turkey / Ayse Cigdem Aktuglu-Zeybek, Ertugrul Kiykim, M. Serif Cansever
Management and future. From weed killer to wonder drug / Edward A. Lock
The Québec NTBC study / Fernando Alvarez, Suzanne Atkinson, Manon Bouchard, Catherine Brunel-Guitton [and others]
Dietary considerations in tyrosinemia type I / Francjan J. van Spronsen, Margreet van Rijn, Uta Meyer, Anibh M. Das
Remaining challenges in the treatment of tyrosinemia from the clinician's viewpoint / Grant A. Mitchell, Hao Yang
Fah knockout animals as models for therapeutic liver repopulation / Markus Grompe
Gene therapy in tyrosinemia: potential and pitfalls / Sophie Carter, Yannick Doyon. - DigitalVolker Schumpelick, Georg Arlt, Joachim Conze, Karsten Junge ; translator, Geraldine O'Sullivan ; illustrator, Gisela Tambour, Andrea Schnitzler.Contents:
I: Introduction
II: Adult inguinal hernia
III: Special hernias
IV: Incision hernias
V: Complications
VI: Miscellaneous.Digital Access Thieme-Connect 2019 - DigitalYuri W. Novitsky, editor.Contents:
Clinical Anatomy and Physiology of the Abdominal Wall
Classification of Hernias
Preoperative Imaging in Hernia Surgery
Preoperative Preparation of the Patient Undergoing Incisional Hernia Repair: Optimizing Chances for Success
Wound Closure and Postoperative Hernia Prevention Strategies
Synthetic Mesh: Making Educated Choices
Biologic Mesh: Classification and Evidenced-Based Critical Appraisal
Biodegradable Meshes in Abdominal Wall Surgery
Abdominal Wall Spaces for Mesh Placement: Onlay, Sublay, Underlay
Reconstructive Options for Small Abdominal Wall Defects
Onlay Ventral Hernia Repair
Rives-Stoppa Retromuscular Repair
Posterior Component Separation via Transversus Abdominis Muscle Release: The TAR Procedure
Open Anterior Component Separation
Endoscopic Anterior Component Separation
Open Anterior Component Separation With Perforator Preservation
Open Parastomal Hernia Repair
Open Flank Hernia Repair
Umbilical Hernia Repair: The Spectrum of Management Options
Managing Complications of Open Hernia Repair
Laparoscopic Ventral Hernia Repair
Laparoscopic Ventral Hernia Repair with Defect Closure
Laparoscopic Parastomal Hernia Repair
Laparoscopic Subxiphoid and Suprapubic Hernia Repair
Laparascopic Repair of Flank Hernias
Robotic Ventral Hernia Repair
Evidence-Based Optimal Fixation During Laparoscopic Hernia Repair: Sutures, Tacks, Glues
Panniculectomy: Tips and Tricks to Maximize Outcomes
Tissue Expansion During Abdominal Wall Reconstructions
Flap Reconstruction of the Abdominal Wall
Diagnosis and Management of Diastasis Recti
Negative Pressure Wound Therapy
Adjuncts to Wound Healing For Abdominal Wall Wounds
Loss of Abdominal Domain: Definition and Treatment Strategies
Enterotomy During Hernia Repair: Prevention and Management
Abdominal Wall Surgery In The Setting of An Enterocutaneous Fistula: Combined Versus Staged Definitive Repair
Management of Infected Mesh in Ventral Hernias
Management of Ventral Hernia in the Morbidly Obese Patient
Emergent Surgical Management of Ventral Hernias
Temporary Abdominal Closure
Chemical Component Separation Using Botulinum Toxin
Groin Hernia Repair: Open Techniques
Laparoscopic TAPP Inguinal Hernia Repair
Laparoscopic Total Extra-Peritoneal Inguinal Hernia Repair
The Extended-View Totally Extraperitoneal (eTEP) Technique for Inguinal Hernia Repair
Inguinal Hernias: An Algorithmic Approach to Procedure Selection
Evaluation and Treatment Of Postoperative Groin Pain
Treating Inguinal Recurrences
Non-Operative Treatment of Sports Hernia
The Surgical Approach to Sports Hernia.Digital Access Springer 2016 - Digitaledited by Russell J. Diefenbach, Cornel Fraefel.Contents:
HSV-1 biology and life cycle / Roger D. Everett
Herpes simplex virus growth, preparation, and assay / Peggy Marconi and Roberto Manservigi
Isolation of herpes simplex virus nucleocapsid DNA / Moriah Szpara
Construction and characterization of bacterial artificial chromosomes (BACs) containing herpes simplex virus full-length genomes / Claus-Henning Nagel, Anja Pohlmann, and Beate Sodeik
Engineering HSV-1 vectors for gene therapy / William F. Goins [and three others]
Herpes simplex virus type 1 (HSV-1)-derived amplicon vectors / Matias E. Melendez, Cornel Fraefel, and Alberto L. Epstein
HSV-1 amplicon vectors as genetic vaccines / Andrea S. Laimbacher and Cornel Fraefel
Modification of HSV-1 to an oncolytic virus / Hiroshi Nakashima and E. Antonio Chiocca
Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo / Nancy M. Sawtell and Richard L. Thompson
Phenotypic and genotypic testing of HSV-1 resistance to antivirals / Andreas Sauerbrei and Kathrin Bohn
Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation / Ju Youn Kim [and four others]
Characterization of extracellular HSV-1 virions by proteomics / Roger Lippé
Precipitation-based assay to analyze interactions of viral particles with cytosolic host factors / Kerstin Radtke, Fenja Anderson, and Beate Sodeik
Affinity purification combined with mass spectrometry to identify herpes simplex virus protein-protein interactions / David G. Meckes Jr.
Preparation of herpes simplex virus-infected primary neurons for transmission electron microscopy / Monica Miranda-Saksena, Ross Boadle, and Anthony L. Cunningham
Multifluorescence live analysis of herpes simplex virus type-1 replication / Michael Seyffert [and three others]
Expression, purification, and crystallization of HSV-1 glycoproteins for structure determination / Samuel D. Stampfer and Ekaterina E. Heldwein
Cryo-EM techniques to resolve the structure of HSV-1 capsid-associated components / Ryan H. Rochat, Corey W. Hecksel, and Wah Chiu
In vivo HSV-1 DNA transport studies using murine retinal ganglion cells / Jolene M. Draper, Graham S. Stephenson, and Jennifer H. LaVail
HSV-1 protein expression using recombinant baculoviruses / Lorry M. Grady, Ping Bai, and Sandra K. Weller
Murine intravaginal HSV-2 challenge model for investigation of DNA vaccines / Joshua O. Marshak, Lichun Dong, and David M. Koelle.Digital Access Springer 2014 - Printedited by Bernard Roizman.Contents:
v
.4. Immunobiology and prophylaxis of human herpesvirus infections. - Digital[edited by] Eyal Herzog.Summary: "Cardiac Care Unit Manual is geared toward all health care providers who rotate or practice in the CCU and must grasp the subtleties when treating patients in a cardiac care unit. Content will be presented"--Provided by publisherDigital Access
- Digital/PrintAllan R. Brasier, editor.Summary: Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.
Contents:
Spectrum of Asthma: an introduction
Genetics and Genomics in Asthma
Proteomics, Metabolomics, and Systems Biology of Asthma
Modeling Complex Data in Asthma
Conclusions and Future Directions.Digital Access Springer 2014 - DigitalAnne Le, editor.Contents:
Part I. Basic Metabolism of Cancer Cells
Glucose metabolism in cancer
Glutamine metabolism in cancer
The heterogeneity of lipid metabolism in cancer
Part II. Heterogeneity of Cancer Metabolism
The multifaceted metabolism of glioblastoma
The intricate metabolism of pancreatic cancers
Breast cancer metabolism
Non-Hodgkinlymphoma metabolism
The metabolism of renal cell carcinomas and liver cancer
Different tumor microenvironments lead to different metabolic phenotypes
The intratumoral heterogeneity of cancer metabolism
Part III. Relationship Between Cancer Cells and Cancer-Associated Fibroblasts
Metabolic relationship between cancer-associated fibroblasts and cancer cells
Targeting metabolic cross talk between cancer cells and cancer-associated fibroblasts
Index.Digital Access Springer 2018 - DigitalAnne Le, editor.Contents:
Part I. Basic Metabolism of Cancer Cells
Glucose Metabolism in Cancer the Warburg effect and Beyond
Glutamine Metabolism in Cancer
The Heterogeneity of Lipid Metabolism in Cancer
Part II. Heterogeneity of Cancer Metabolism
The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions
The Intricate Metabolism of Pancreatic Cancers
The heterogeneity of breast cancer metabolism for therapy
Non-Hodgkin Lymphoma Metabolism
The Heterogeneity Metabolism of Renal Cell Carcinomas
The Heterogeneity Metabolism of Liver Cancer
Different Tumor Microenvironments Lead to Different Metabolic Phenotypes
The Intratumoral Heterogeneity of Cancer Metabolism
Cancer Stem Cells Metabolism
Metabolism of Immune cells in the Tumor Microenvironment
Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts
Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells
Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts
Part IV. The metabolic interplay between cancer and other diseases
Diabetes and Cancer: the Epidemiological and Metabolic Associations
Bridging the Metabolic Parallels between Neurological Diseases and Cancer
Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy
Index. - Digitaledited by Avishai Henik, Wim Fias.Summary: Heterogeneity of Function in Numerical Cognition presents the latest updates on ongoing research and discussions regarding numerical cognition. With great individual differences in the development or function of numerical cognition at neuroanatomical, neuropsychological, behavioral, and interactional levels, these issues are important for the achievement of a comprehensive understanding of numerical cognition, hence its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills. These functions are essential for the proper development of numerical cognition.
Contents:
1. Numbers and language: what's new in the past 25 years?
2. The interplay between learning arithmetic and learning to read: insights from developmental cognitive neuroscience
3. Language and arithmetic: the potential role of phonological processing
4. Discussion: specific contributions of language functions to numerical cognition
5. An introduction to attention and its implacation for numerical cognition
6. The contol of selective attention and emerging mathematical cognition: beyond unidirectional influences
7. Performance control in numerical cognition: insights from strategic variations in arithmetic during the life span
8. The interplay between proficiency and executive control
9. How big is many? Development of spatial and numerical magnitude understanding
10. Is visuospatial reasoning related to early mathematical development? A critical review
11. Neurocognitive evidence for spatial contributions to numerical cognition
12. Which space for numbers?
13. Cognitive interferences and their development in the context of numerical tasks: review and implications
14. The role of executive function skills in the development of children's mathematical competencies
15. Systems neuroscience of mathematical cognition and learning: basic organization and neural sources of heterogeneity in typical and atypical development
16. (How) are executive functions actually related to arithmetic abilities?
17. Numerical cognition and memory (ies)
18. Hypersensitivity-to-interference in memory as a possible cause of difficulty in arithmetic facts storing
19. Working memory for serial order and numerical cognition: what kind of association?
20. Do not forget memory to understand mathematical cognition
Index.Digital Access ScienceDirect 2018 - DigitalMarco Mossobrio, Redento Mora, editors.Summary: This book provides a thorough description of hexapod external fixators, from the theoretical basis to their practical application. Indications and practical use in current Orthopaedic practice are addressed in detail, offering the reader essential insights into the strengths and limitations of these devices. The main aspects covered, include primary (congenital) and secondary (acquired) deformities of the limbs: the etiology, pathomechanics, clinics, technical tips and tricks and suggested frame assemblies are presented. Each chapter addresses a specific Orthopaedic problem and includes representative clinical cases commented on by the authors. Illustrations and X-ray images support the discussion of the various themes treated in the textbook. Special attention is also given to deformity morphology and the consequent geometry of correction, as well as economical aspects and the biological risks of radiation exposure. A review of current nomenclature in external fixation is also provided as a quick-reference resource. Offering clear and straightforward descriptions of these devices and their current use in practice, prepared by leading international experts, this book will benefit expert surgeons and residents alike.
Contents:
1. History and evolution of hexapod external fixators
2 Principles of hexapod external fixators functions: software and hardware
3 Characteristics and usage modalities. Main systems
4 Hexapod external fixators in acute fracture treatment and their complications
5 Hexapod external fixators in the treatment of axial and rotation deformities and limb length discrepancies
6 Hexapod external fixators in bone defect treatment
7 Hexapod external fixators in pediatric deformities
8 Hexapod external fixators in articular stiffness treatment
9 Hexapod external fixators in foot deformity correction
10 Problems, challenge, complications in hexapod external fixation systems. Contraindications
11 Hexapod external fixators upgrade: motor powered frames , automation, deformity correction scheduling and remote control
12 Ancillary usage of hexapod external fixators: Fixator assisted nailing (FAN), fixator assisted locking plate (FALP), lenghtening over nail (LON), bone transport over a nail (BTON) and lenghtening and then nailing (LATN). External to internal fixation conversion timing
13 Ionizing radiation exposure
14 Economical aspects and practical considerations
15 Appendix: Deformity geometry
16 Nomenclature. - Digitalby Jarrett J. Krosoczka.Summary: "In kindergarten, Jarrett Krosoczka's teacher asks him to draw his family, with a mommy and a daddy. But Jarrett's family is much more complicated than that. His mom is an addict, in and out of rehab, and in and out of Jarrett's life. His father is a mystery -- Jarrett doesn't know where to find him, or even what his name is. Jarrett lives with his grandparents -- two very loud, very loving, very opinionated people who had thought they were through with raising children until Jarrett came along"-- Provided by publisherDigital Access 2018Limited to 1 simultaneous userSUNet ID login required
- DigitalMuhammed Ashraf Memon, editor.
- DigitalEmilia Manzato, Massimo Cuzzolaro, Lorenzo Maria Donini, editors.Summary: This book provides up-to-date information on lesser known eating disorders (EDs) and eating related disorders. EDs and eating-related disorders include a highly heterogeneous group of syndromes and symptoms characterized by abnormal eating and weight control behaviors that can appear in all genders and ages. EDs can lead to high rates of morbidity and mortality, especially if they are misdiagnosed and untreated. The risk of underestimation is high for the lesser-known EDs, and when unhealthy eating behaviors appear in unusual situations, such as some medical and psychiatric pathologies, adults and the elderly, sexual minorities etc. The volume examines EDs in specific populations (the elderly, males, infants and toddlers, sexual minorities, etc.). Several chapters explore in detail lesser-known EDs (anorexia athletica, avoidant/restrictive food intake disorder, chewing and spitting, EDs by proxy, EDs after bariatric surgery, muscle dysmorphia, night-eating syndrome, nocturnal sleep-related eating disorder, orthorexia nervosa, pica, rumination disorder, etc.). Finally, other chapters address features of unhealthy eating and weight control behaviors associated with medical diseases (achalasia, craniopharyngioma, cystic fibrosis, cyclic vomiting syndrome, diabetes, dysphagia, Kleine-Levin syndrome, Klinefelter syndrome, Parkinson disease, Prader-Willi syndrome, Turner syndrome, etc.) The book will be a valuable resource for all health professionals who work in the fields of psychiatry, clinical psychology, eating disorders, obesity, medicine, clinical nutrition, public health, and prevention, allowing them to broaden their understanding of these disorders, and to enhance their clinical ability to diagnose them.
- Digitalvolume editors, Hans Konrad Biesalski, Regina Birner.Contents:
Economic and political innovation for nutritional improvement
What does it need to improve nutrition quality? The role of public partners
The devil is in the detail: understanding the governance challenges of implementing nutrition-specific programs on a large scale
Post-2015 agenda and sustainable developmental goals: where are we now? Global opportunities to address malnutrition in all its forms, including hidden hunger
Without land, no crops- without diversity, no healthy, and sustainable diets
A challenge for international cooperation
Working with Santal villagers, West Bengal, India: Moringa and kitchen gardens to combat malnutrition, 2012-2017
Multidimensional nutritional welfare of children in Southern Africa: a human rights consistent approach
How to accelerate the end of hunger and undernutition
On the link between production diversity and dietary quality in smallholder farm households
Reducing mineral and vitamin deficiencies through biofortification: progress under HarvestPlus
The most hidden of all hidden hungers: the global deficiency in DHA and EPA and what to do about it
The nutrition paradox in India: the coexistence of undernutrition and overnutrition
Transdisciplinary approaches and methods in the context of food and nutrition security
Unveilling the menace of hidden hunger in refugee camps: nutritional status among refugees, states responsibility, and key African strategies on nutrition
Combating hidden hunger in agriculture perspective
Latin America and the Caribbean: strategies to fight hidden hunger
Strategies to fight hidden hunger in Ethiopia, Egypt, Sudan and Tunisia
Agricultural assistance to vulnerable, food-insecure female-headed households in Kyrgyzstan
Linking agriculture and natural resource management towards nutrition security (LANN+)
Vitamin D deficiency: a public health issue in high- and low-income countries or just hype?
Nutrition education cell, a community based approach to fight against child undernutrition and strength community resilience, in rural area in Burkina Faso
Students4Kids: winning project, growing the tree against hunger (Ensete ventricosum) in Zambia.Digital Access Karger 2018 - Digitalvolume editor, Hans Konrad Biesalski.Summary: "This book presents as scientific papers the focus and discussions of the 4th International Congress Hidden Hunger held in March 2019, the topic of which is hidden hunger and the double burden of global malnutrition in all its forms. The global nutrition situation, its causes and possible solutions are presented from the perspectives of governmental and non-governmental organizations, politicians, economists, nutritionists, and agricultural scientists"-- Provided by publisher.
Contents:
Unravelling the Food-Health Nexus to Build Healthier Food Systems
Abstract
Health Impacts of Food Systems and Their Estimated Costs
Why the Heath Impacts Are Systematically Reproduced
Leverage Points to Contribute to Transformation to Healthier Food Systems
Disclosure Statement
References
"Fit for Life"
German Perspectives on How to Tackle the Double Burden of Malnutrition: Healthy Start
Young Family Network
Abstract Focusing on Prevention of Malnutrition in Mothers and Their Children
Healthy Start
Young Family Network: Approaches towards Successful Prevention and Health Promotion
The "Healthy Start
Young Family Network"
Importance of Appropriate Conditions for Behavioral Change
The Importance of Networking in Other Areas of Healthy Lifestyle Promotion
Conclusion
References
Unlocking the Hidden Hunger Crises: The Power of Public-Private Partnerships
Abstract
Recommendations
References Addressing Hidden Hunger in School-Aged Children and Adolescents within the Context of the Food System
Abstract
Interventions to Address Hidden Hunger through the Food System
The Way Forward
Conflict of Interest Statement
References
Africa's Changing Food Environments and Nutritional Effects on Adults and Children
Abstract
Background
Panel Data Evidence from Kenya
Supermarket Effects on Adults' Diets and Nutrition
Supermarket Effects on Adults' Health
Supermarket Effects on Children and Adolescents
Interventions Regarding Supermarkets
Conclusion Conflict of Interest Statement
Funding Sources
References
Fruits and Vegetables in International Agricultural Research: A Case of Neglect?
Abstract
How Are F+Vs Defined? A Case of Fuzziness
Why Does the CGIAR Not Have a Center Focused on F+Vs?
Research Investment in F+Vs
The Future for F+Vs in International Public Research
Conclusion
Acknowledgements
Disclosure Statement
References
Gender Discrimination: Contribution to the Burdens of Malnutrition in Communities in Buea, the South-West Region of Cameroon
Abstract
Statement of the Problem
Objectives Methodology
Results
Discussion
Conclusion
Disclosure Statement
References
The Importance of Food Supplements for Public Health and Well-Being
Abstract
Adequate Intake of Nutrients
Optimal Intake of Nutrients
Intake of Nutrients for Reducing Disease Risk
Conclusions
Disclosure Statement
From Individual Nutrients to Sustainable Nutrition
Abstract
Responsibly Delicious
Nutritious Diets
Challenges
Conclusion
Conflict of Interest Statement
References
Market-Driven Food Fortification to Address Dietary Needs
AbstractDigital Access Karger 2020 - Digital[edited by] Giuseppe Micali.Contents:
Epidemiology and pathogenesis / Vincenzo Bettoli and Giulia Ruina
Clinical features and diagnostic clues / Maria Letizia Musumeci, Maria Rita Nasca, Piera Catalfo, Karishma Bhatt, and Giuseppe Micali
Histopathology / Franco Rongioletti
Classification and severity scales / Giuseppe Monfrecola and Matteo Megna
Correlation between severity and its impact on quality of life / Nevena Skroza and Maria Concetta Potenza
Comorbidities and complex syndromes / Gabriella Fabbrocini and Valerio De Vita
Complications / Teresa Oranges, Valentina Dini, Andrea Chiricozzi, Salvatore Panduri, and Marco Romanelli
Ultrasound imaging / Antonio Martorell
Radiological imaging / Giuseppe Petrillo, Stefano Palmucci, and Claudia Trombatore
Skin imaging : dematoscopy and videodermatoscopy / Francesco Lacarrubba, Anna Elisa Verzì, Federica Fiorentini, and Giuseppe Micali
Differential diagnosis / Stefano Veraldi, Elena Guanziroli, and Mauro Barbareschi.Digital Access Wiley 2017 - Digitaleditors, Alexa B. Kimball, Gregor B.E. Jemec.Summary: A concise but comprehensive pocket handbook that provides an accessible and up-to-date introductory overview of this debilitating skin disease. Written by highly recognizable leaders in the field, this book presents essential information on the pathophysiology, clinical presentation, diagnosis and management strategies and options for hidradenitis suppurativa, forming an ideal resource to increase awareness of this disease among healthcare professionals.
Contents:
1 Editor biographies
2 Clinical Presentation of Hidradenitis Suppurativa
3 Pathophysiology of Hidradenitis Suppurativa
4 Diagnostic Workup
5 Treatment of Hidradenitis Suppurativa.Digital Access Springer 2017 - DigitalErik R. Swenson, Peter Bärtsch, editors.Summary: Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude.--Excerpt from abstract.
Contents:
1. Cellular and Molecular Mechanisms of O2 Sensing / Paul T. Schumacker-- 2. Cellular and Molecular Defenses Against Hypoxia / Stilla Frede and Joachim Fandrey
3. Control of Breathing / Luc J. Teppema and Remco R. Berendsen
4. Lung Function and Gas Exchange / Andrew M. Luks and Susan R. Hopkins
5. Pulmonary Circulation / Marco Maggiorini, Peter Bärtsch, and Erik R. Swenson
6. Cardiovascular System / Aaron L. Baggish, Eugene E. Wolfel, and Benjamin D. Levine
7. Cerebral Circulation and Brain / Philip N. Ainslie, Mark H. Wilson, and Christopher H.E. Imray
8. Autonomic Nervous System / Mark J. Drinkhill, Roger Hainsworth, and Victoria E. Claydon
9. Skeletal Muscle Tissue Changes with Hypoxia / Hans Hoppeler, Matthias Mueller, and Michael Vogt
10. Blood and Haemostasis / James S. Milledge and Peter Bärtsch
11. Renal Function and Fluid Homeostasis / Erik R. Swenson and Niels V. Olsen
12. Endocrine Function / Jean-Paul Richalet
13. Gastrointestinal Function / Noor Hamad and Simon Travis
14. Immune System / Robert S. Mazzeo and Erik R. Swenson
15. Nutrition and Metabolism / George A. Brooks
16. Exercise / Carsten Lundby
17. Sleep / Yvonne Nussbaumer-Ochsner and Konrad E. Bloch
18. Reproduction and Growth / Susan Niermeyer
19. Human Evolution at High Altitude / Cynthia M. Beall
20. Acute Mountain Sickness and High Altitude Cerebral Oedema / Peter Bärtsch and Damian Miles Bailey
21. High-Altitude Pulmonary Edema (HAPE) / Robert B. Schoene and Erik R. Swenson
22. Chronic Mountain Sickness / Fabiola León-Velarde, María Rivera-Ch, Luis Huicho, and Francisco C. Villafuerte
23. High Altitude and Common Medical Conditions / Andrew M. Luks and Peter H. Hackett.Digital Access Springer 2014 - DigitalArnold von Eckardstein, Dimitris Kardassis, editors.Contents:
Preface
Part 1. Physiology of HDL
Part 2. Pathology of HDL
Part 3. Possible Indications and Target Mechanisms of HDL Therapy
Part 4. Treatments for Dyslipidemias and Dysfunction of HDL. - DigitalKyung-Hyun Cho.Summary: This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians.
Contents:
Preface
Chapter 1. Understanding HDL: overview
1-1. HDL and disease
1-2. HDL functions and clinical applications
1-3. HDL composition : apolipoproteins and enzymes
1-4. Maturation of HDL
1-5. HDL and blood pressure
Chapter 2. Change of HDL by life style
2-1. Exercise and HDL
2-2. Smoking and HDL
2-3. Elderlys HDL
2-4. HDL depends on body weight
2-5. HDL from obese but healthy subject
2-6. HDL and apoA-I in smokers breast milk
2-7. Breast milk from frequent trans fatty acid consumers
2-8. HDL in cord blood from small neonates
Chapter 3. Change of HDL in various diseases
3-1. HDL from patients with myocardial infarction
3-2. HDL from patients with female angina pectoris
3-3. HDL and metabolic syndrome
3-4. HDL from male patients with atrial fibrillation
3-5. HDL from female patients with atrial fibrillation
3-6. HDL from patients with hemorrhagic fever with renal syndrome
3-7. HDL from patients with rheumatoid arthritis
3-8. HDL and prehypertension
Chapter 4. Detriment of HDL by pollutant and its evaluation
4-1. Particulate matter and HDL
4-2. Phthalate and HDL
4-3. Cadmium and HDL
4-4. Humidifier Sterilizer and HDL
4-5. Detection of dysfunctional HDL by microfluidics
4-6. Evaluation of dysfunctional HDL using zebrafish embryo
Chapter 5. Change of HDL by food ingredient
5-1. Fructose and apoA-I
5-2. Fructose and impairment of HDL functionality
5-3. Artificial sweeteners and apoA-I
5-4. Artificial sweeteners (aspartame, saccharin) and HDL
5-5. Aldoketohexoses and HDL
5-6. Iron and HDL
5-7. Trans fat and HDL
5-8. Salt and HDL 576 p
Summary and perspectives.Digital Access Springer 2019 - DigitalKyung-Hyun Cho.Summary: This book is the second of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. In this volume, the focus is on the improvement of HDL, enhancement of its functionality, and the use of HDL for therapeutic purposes. In the first section, up-to-date information is provided on such topics as the tumor regression-promoting and antidiabetic activities of reconstituted HDL containing V156K apolipoprotein A-I, the enhancement of HDL effects by high doses of vitamin C, the benefits derived from incorporation of growth hormones 1 and 2 into rHDL, and the biological functions of omega-3 linolenic acid in rHDL. The enhancement of HDL functionality by policosanol and the resultant benefits are thoroughly examined in a separate section. Readers will also find the latest information on clinical applications of HDL. Here, specific topics include the enhancement of adenoviral gene delivery and the delivery of rapamycin. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians.
Contents:
Chapter 1. Improvement of HDL
1-1. Clinical application of HDL: Overview
1-2. Regression effect of V156K-apoA-I
1-3. Anti-diabetic effect of V156K-apoA-I
1-4. Vitamin C and HDL
1-5. Growth hormone-1 in HDL
1-6. Growth hormone-2 in HDL
1-7. Omega-3 and HDL
Chapter 2. HDL as therapeutic tools
2-1. Delivery vehicle for therapeutics : Overview
2-2. Gene delivery: adenovirus and V156K-apoA-I
2-3. Solubilization of rapamycin and delivery
2-4. Solubilization of minoxidil and delivery
Chapter 3. Enhancement of HDL by policosanol: anti-aging and longevity
3-1. Policosanol and HDL functionality
3-2. Policosanol and raising HDL in zebrafish
3-3. Policosanol and CETP inhibition: human trial 8 weeks
3-4. Policosanol and blood pressure lowering: human trial 8 weeks
3-5. Policosanol blood pressure lowering human trial for 24 weeks
3-6. Policosanol and improvement of aortic stiffness
3-7. Policosanol and blood pressure lowering in rat model
3-8. Twelve week consumption of policosanol and lowering blood pressure
3-9. Publication analysis of policosanol-related studies
3-10. Athero-protective effects of policosanol and sugar cane wax acid
3-11. Cuban sugarcane wax acids and policosanol improved serum lipid profiles
Summary and perspectives
Epilogue.Digital Access Springer 2019 - Digitaledited by Agamemnon J. Carpousis.Contents:
Characterizing the role of exoribonucleases in the control of microbial gene expression : differential RNA-Seq / Vânia Pobre and Cecília M. Arraiano
Conformational studies of bacterial chromosomes by high-throughput sequencing methods / Virginia S. Lioy and Frederic Boccard
Large-scale measurement of mRNA degradation in Escherichia coli : to delay or not to delay / Sandrine Laguerre, Ignacio Gonzalez, Sebastien Nouaille, Annick Moisan, Nathalie Villa-Vialaneix, Christine Gaspin, Marie Bouvier, Agamemnon J. Carpousis, Muriel Cocaign-Bousquet, and Laurence Girbal
FASTBAC-Seq : functional analysiS of toxin-antitoxin systems in BACteria by deep sequencing / Sara Masachis, Nicolas J. Tourasse, Sandrine Chabas, Olivier Bouchez, and Fabien Darfeuille
The challenges of genome-wide studies in a unicellular eukaryote with two nuclear genomes / Sandra Duharcourt and Linda Sperling
CLIP-seq in bacteria : global recognition patterns of bacterial RNA-binding proteins / Liis Andresen and Erik Holmqvist
High-resolution profiling of NMD targets in yeast / Feng He, Alper Celik, Richard Baker, and Allan Jacobson
Generation of a metagenomics proximity ligation 3C library of a mammalian gut microbiota / Théo Foutel-Rodier, Agnes Thierry, Romain Koszul, and Martial Marbouty
Genome-wide mapping of yeast retrotransposon integration target sites / Anastasia Barkova, Amna Asif-Laidin, and Pascale Lesage
Genome-wide quantitation of protein synthesis rates in bacteria / Grace E. Johnson and Gene-Wei Li
On the prowl : an in vivo method to identify RNA partners of a sRNA / Marie-Claude Carrier, Claire Morin, and Eric Masse
Analysis of bacterial transcription by "massively systematic transcript end readout," MASTER / Irina O. Vvedenskaya, Seth R. Goldman, and Bryce E. Nickels
Transcriptomic approaches for studying quorum sensing in Vibrio cholerae / Roman Herzog and Kai Papenfort
In vitro study of the major Bacillus subtilis ribonucleases Y and J / Liliana Mora, Saravuth Ngo, Soumaya Laalami, and Harald Putzer
Mapping 5'-ends and their phosphorylation state with EMOTE, TSS-EMOTE, and nEMOTE / Peter Redder
MS2-affinity purification coupled with RNA sequencing approach in the human pathogen Staphylococcus aureus / David Lalaouna, Emma Desgranges, Isabelle Caldelari, and Stefano Marzi
Noncoding RNAs in archaea : genome-wide identification and functional classification / Anne Buddeweg, Michael Daume, Lennart Randau, and Ruth A. Schmitz
Methodology for ribosome profiling of key stages of the Caulobacter crescentus cell cycle / James R. Aretakis, Nadra Al-Husini, and Jared M. Schrader
Transcriptome-wide analysis of protein-RNA and RNA-RNA interactions in pathogenic bacteria / Jai J. Tree, Kenn Gerdes, and David Tollervey
Profiling RNA polymerase II phosphorylation genome-wide in fission yeast / Tea Kecman, Dong-Hyuk Heo, and Lidia Vasiljeva
Toward cell type-specific in vivo dual RNA-seq / Lutz Frönicke, Denise N. Bronner, Mariana X. Byndloss, Bridget McLaughlin, Andreas J. Baumler, and Alexander J. Westermann
Genomic analysis of DNA double-strand break repair in Escherichia coli / A.M. Mahedi Hasan, Benura Azeroglu, and David R.F. Leach.Digital Access ScienceDirect 2018 - Digital/PrintHarris G. Fienberg, Garry P. Nolan, editors.Summary: This volume highlights the most interesting biomedical and clinical applications of high-dimensional flow and mass cytometry. It reviews current practical approaches used to perform high-dimensional experiments and addresses key bioinformatic techniques for the analysis of data sets involving dozens of parameters in millions of single cells. Topics include single cell cancer biology; studies of the human immunome; exploration of immunological cell types such as CD8+ T cells; decipherment of signaling processes of cancer; mass-tag cellular barcoding; analysis of protein interactions by proximity ligation assays; Cytobank, a platform for the analysis of cytometry data; computational analysis of high-dimensional flow cytometric data; computational deconvolution approaches for the description of intracellular signaling dynamics; and hyperspectral cytometry. All 10 chapters of this book have been written by respected experts in their fields. It is an invaluable reference book for both basic and clinical researchers.
Contents:
High Dimensional Single Cell Cancer Biology
Studying the Human Immunome: The Complexity of Comprehensive Leukocyte Immunophenotyping
High-dimensional Analysis of Human CD8+ T Cell Phenotype, Function and Antigen-Specificity
Mass Cytometry to Decipher the Mechanism of Non-genetic Drug Resistance in Cancer
A Practical Guide to Multiplexed Mass Cytometry
Analysis of Protein Interactions in situ by Proximity Ligation Assays
Cytobank: Providing an Analytics Platform for Community Cytometry Data Analysis and Collaboration
Computational Analysis of High-Dimensional Flow Cytometric Data for Diagnosis and Discovery
Shooting Movies of Signaling Network Dynamics with Multiparametric Cytometry
Hyperspectral Cytometry. - DigitalCandice W. Jones.Summary: "This positive parenting guide will help you understand how children develop and how discipline shapes not only your child's behavior but their overall health and well-being. With your child's developmental stages in mind, you'll be empowered to create a family discipline plan that manages misbehavior and encourages positive behavior. High Five Discipline is packed with developmentally appropriate strategies to tame tantrums, stop sibling squabbles, and reward better behavior, to create a calmer, more harmonious home"--Page [4] of cover.
Contents:
Personal history: My "her"story
Essential discipline dynamics
Adult in the mirror
Child basics: Act like a parent but think like a child
Establishing a family discipline plan.Digital Access AAP ebooks 2022 - DigitalAnnalisa Carlucci, Salvatore M. Maggiore, editors.Summary: This book presents the state of the art in high-flow nasal cannula (HFNC), an oxygen therapy technique that has recently proven to be a very promising approach to supporting respiratory function in several medical fields. In the opening part of the book, readers will learn the differences between high-flow and low-flow techniques and gain an overview of HFNCs technical aspects and physiological effects. The book subsequently describes the pathophysiological mechanisms involved in different respiratory diseases, analyzing how this technique positively impacts patients respiratory status. The authors highlight clinical applications of HFNC, both in adults and in children, in various clinical settings e.g. intensive care and semi-intensive care unit, emergencies, rehabilitation etc. and present tips, tricks and pitfalls, as well as up-to-date reports on technical issues. The book is intended for pneumologists, intensivists, anesthesiologists, ED doctors, rehabilitation therapists, internists and oncologists, as well as fellows and nurses in these fields.
Contents:
1 Conventional oxygen therapy: technical and physiologic issues
2 High-flow: technical aspect
3 Physiological effects of high flow
4 Clinical applications of high flow nasal cannula in hypoxemic acute respiratory failure
5 Clinical applications of high flow nasal cannula during intubation and weaning from mechanical ventilation
6 Clinical applications of high flow nasal cannula in the operating room
7 Clinical applications in the acute setting: obstructive lung diseases
8 Clinical applications in Pulmonary rehabilitation
9 Clinical applications in particular setting
10 Physiological Effects and clinical applications in children
11 Future perspectives. - DigitalThomas Bodenheimer [and eight others].Summary: "Residency teaching programs have two equally important missions: educating tomorrow's doctors and caring for today's patients. This report offers observations made in 23 family medicine, internal medicine, and pediatric resident teaching clinics around the United States. We found that several of those residency programs are demonstrating that good education for tomorrow's doctors requires excellent care for today's patients. Currently, clinics that train the nation's future primary care physicians face major challenges. Faculty physicians and resident learners often spend only one to two half-days per week in clinic, making it difficult to provide continuity of care and prompt access for patients, who are often from underserved communities. Moreover, a "training gap" exists between the inpatient focus of many residency programs and the reality that the majority of health care occurs in the outpatient setting. Residents and medical students are less likely to enter ambulatory primary care careers as a result of poor experiences in teaching clinics. The observations offered in this report are based on detailed site visits conducted from 2013 to 2015 by a team from the Center for Excellence in Primary Care (CEPC) at the University of California, San Francisco. The observations are organized according to the primary care improvement model—the Building Blocks of High-Performing Primary Care—which includes 10 features of good primary care"--Executive summary.
Contents:
Executive summary
Introduction
Conceptual model: the building blocks of high-performing primary care
Building block 1: Engaged leadership
Building block 2: Data-driven improvement
Building block 3: Empanelment
Building block 4: Team-based care
Building block 5: Patient-team partnership
Building block 6: Population management
Building block 7: Continuity of care
Building block 8: Prompt access to care
Building blocks 7 and 8: Continuity of care and prompt access to care
Building block 9: Comprehensiveness and care coordination
Building block 10: Template of the future
Resident building block 1: Resident scheduling
Resident building block 2: Resident engagement
Resident building block 3: Resident worklife
Conclusion
References.Digital Access R2Library 2016 - DigitalBrendon Burchard.Summary: "THESE HABITS WILL MAKE YOU EXTRAORDINARY. Twenty years ago, author Brendon Burchard became obsessed with answering three questions: 1. Why do some individuals and teams succeed more quickly than others and sustain that success over the long term? 2. Of those who pull it off, why are somemiserableand others consistently happy on their journey? 3. What motivates people to reach for higher levels of success in the first place, and what practices help them improve the most? After extensive original research and a decade as the world's leading high performance coach, Burchard found the answers. It turns out that just six deliberate habits give you the edge. Anyone can practice these habits and, when they do, extraordinary things happen in their lives, relationships, and careers. Which habits can help you achieve long-term success and vibrant well-being no matter your age, career, strengths, or personality? To become a high performer, you must seek clarity, generate energy, raise necessity, increase productivity, develop influence, and demonstrate courage. This book is about the art and science of how to cultivate and practice these proven habits. Whether you want to get more done, lead others better, develop skill faster, or dramatically increase your sense of joy and confidence, the habits in this book will help you achieve it faster. Each of the six habits is illustrated by powerful vignettes, cutting-edge science, thought-provoking exercises, and real-world daily practices you can implement right now. If you've ever wanted a science-backed, heart-centered plan to living a better quality of life, it's in your hands. Best of all, you can measure your progress. A link to a free professional assessment is included in the book"-- Provided by publisher.
Contents:
Beyond natural: the quest for high performance
Section one. Personal habits
Seek clarity
Generate energy
Raise necessity
Section two. Social habits
Increase productivity
Develop influence
Demonstrate courage
Section three. Sustaining success
Beware three traps
The #1 thing
Summary guide.Digital Access OverDrive 2017Limited to 1 simultaneous userSUNet ID login required - DigitalKazuyuki Akasaka, Hitoshi Matsuki, editors.Contents:
Part I. Why and how proteins denature under prssure?
Part II. Volume, compressibility, fluctuation and interaction in proteins
Part III. Pressure and functional sub-states in proteins
Part IV. Pressure and protein folding and assembly
Part V. Pressure effects on biological membranes
Part VI. Pressure adaptation and tolerance of proteins and living organisms
Part VII. High pressure food processing and sterilization
Part VIII. Pressure effects on motility, physiology and health
Part IX. Methodology.Digital Access Springer 2015 - DigitalHigh Reliability Organizations : a Healthcare Handbook for Patient Safety & Quality. Second edition.[edited by] Cynthia A. Oster, Jane S. Braaten.Summary: "Patient safety and quality of care are critical concerns of healthcare consumers, payers, providers, organizations, health systems, and governments. Although a strong body of knowledge shows that high-reliability methods enable the most efficient, safe, and effective care, these methods have yet to be completely implemented across healthcare. According to authors Cynthia Oster and Jane Braaten, nurses-who are on the frontline of providing safe and effective care-are ideally situated to drive high reliability. High Reliability Organizations: A Healthcare Handbook for Patient Safety & Quality, Second Edition, equips nurses and healthcare professionals with the tools necessary to establish an error detection and prevention system. This new edition builds on the foundation of the first book with best practices, relevant exemplars, and important discussions about cultural aspects essential to sustainability. New material focuses on: High-reliability performance during a pandemic, organizational learning and tiered safety huddles, high reliability in infection prevention and ambulatory care, the emerging field of human factors engineering within healthcare, creating a virtual resource toolkit for frontline staff"-- Provided by publisherDigital Access
- DigitalW. Richard Webb, MD, Professor Emeritus of Radiology and Biomedical Imaging, Emeritus Member, Haile Debas Academy Educators, University of California San Francisco, San francisco, California, Nestor L. Müller, MD, PhD, David P. Naidich, MD, FACR, FAACP, Professor Emeritus of Radiology, Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada, Profressor of Radiology and Medicine, New York University, Langone Medical center, New York, New York.Contents:
Technical aspects of HRCT
Normal lung anatomy
HRCT findings : linear and reticular opacities
HRCT findings : multiple nodules and nodular opacities
HRCT findings : parenchymal opacification
HRCT findings : air-filled cystic lesions
HRCT findings : decreased lung attenuation
The idiopathic interstitial pneumonias, part 1: usual interstitial pneumonia/idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
The idiopathic interstitial pneumonias, part 2 : cryptogenic organizing pneumonia, acute interstitial pneumonia, respiratory bronchiolitis-interstitial lung disease, desquamative interstitial pneumonia, lymphocytic interstitial pneumonia, and pleuroparenchymal fibroelastosis
Collagen vascular diseases
Diffuse pulmonary neoplasms and pulmonary lymphoproliferative diseases
Sarcoidosis
Pneumoconiosis, occupational, and environmental lung disease
Hypersensitivity pneumonitis and eosinophilic lung diseases
Drug-induced lung diseases and radiation pneumonitis
Miscellaneous infiltrative lung diseases
Infections
Pulmonary edema and the acute respiratory distress syndrome
Cystic lung diseases
Emphysema and chronic obstructive pulmonary disease (COPD)
Airways diseases
Pulmonary hypertension and pulmonary vascular disease
Illustrated glossary of high-resolution CT terms
Appearances and characteristics of common diseases.Digital Access Ovid 2015 - DigitalJosef F. Bille, editor.Summary: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology - New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Contents:
PART ONE
Breaking the Diffraction Barrier in Fluorescence Microscopy.- High-Resolution 3D Light Microscopy with STED and RESOLFT.- PART TWO
Retinal Imaging and Image Guided Retina Treatment.- Scanning Laser Ophthalmoscopy (SLO).- Optical Coherence Tomography (OCT) -Principle and Technical Realization.- Ophthalmic Diagnostic Imaging
Retina. .- Ophthalmic Diagnostic Imaging
Glaucoma.- OCT Angiography (OCTA) in Retinal Diagnostics.- OCT-based Velocimetry for Blood Flow Quantification.- In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells.- Two-Photon Laser Scanning Ophthalmoscope.- Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).- Selective Retina Therapy.- PART THREE
Anterior Segment Imaging and Image Guided Treatment.- In Vivo Confocal Scanning Laser Microscopy.- Anterior Segment OCT.- Femtosecond-Laser-Assisted Cataract Surgery (FLACS).- Refractive Index Shaping
In-Vivo Optimization of an Implanted Intraocular Lens (IOL).- PART FOUR- Adaptive Optics in Vision Science and Ophthalmology.- The Development of Adaptive Optics and its Application in Ophthalmology.- Adaptive Optics for Photoreceptor-Targeted Psychophysics.- Compact Adaptive Optics Scanning Laser Ophthalmoscope with Phase Plates. - Digitalsenior editor, Nan H. Troiano ; editors, Patricia M. Witcher, Suzanne McMurtry Baird.Summary: This comprehensive analysis of critical care obstetrics concepts offers a summary of research findings and top-notch clinical expertise. Made for perinatal clinicians who provide care to pregnant women with high-risk or critical care conditions -- Cover.
Contents:
Maternal morbidity and mortality / Patricia M. Witcher and Michael Lindsey
Improving maternal outcomes / Patricia M. Witcher, Cynthia Chazott, and Bonnie Flood Chez
Critical care obstetric capabilities : development strategies / Suzanne Mcmurtry Baird and Stephanie Martin
Invasive hemodynamic and oxygen transport monitoring during pregnancy / Nan H. Troiano And Sreedhar Gaddipati
Mechanical ventilation during pregnancy / Nan H. Troiano and Thomas M. Jenkins
Pharmacologic agents / Suzanne Mcmurtry Baird, Stephen D. Krau, and Michael A. Belfort
Hypertension in pregnancy / Carol J. Harvey and Baha M. Sibai
Cardiac disorders in pregnancy / Sreedhar Gaddipati and Nan H. Troiano
Pulmonary disorders in pregnancy / Brian A. Mason and Karen Dorman
Diabetic ketoacidosis and continuous insulin infusion management in pregnancy / Maribeth Inturrisi, Nancy C. Lintner, and Kimberlee Sorem
Anesthesia emergencies in the obstetric setting / Patricia M. Witcher and Keith Mclendon
Induction of labor / Washington C. Hill and Carol J. Harvey
Acute renal failure /Betsy B. Kennedy, Carol J. Harvey, and George R. Saade
Cardiopulmonary resuscitation in pregnancy / Deborah Anne Cruz, Patricia Marie Constanty, and Shailen S. Shah
Obstetric hemorrhage / Carol J. Harvey and Gary A. Dildy
Disseminated intravascular coagulation in pregnancy / Melissa C. Sisson and Marcy M. Mann
Venous thromboembolism in pregnancy / Patricia M. Witcher and Lewis Hamner
Sepsis in pregnancy / Julie M. R. Arafeh and Bonnie K. Dwyer
Amniotic fluid embolus (anaphylactoid syndrome of pregnancy) / Renee' Jones and Steven L. Clark
Perinatal infection / Patrick Duff
Trauma in pregnancy / Donna Ruth and Richard S. Miller
Maternal obesity : effects on pregnancy / Amy H. Picklesimer and Karen Dorman.Digital Access - PrintRonald W. Dudek, Professor, Brody School of Medicine, East Carolina University, Department of Anatomy and Cell Biology, Greenville, North Carolina, Thomas M. Louis, Professor, Brody School of Medicine, East Carolina University, Department of Anatomy and Cell Biology, Greenville, North Carolina.Summary: "High-Yield Gross Anatomy addresses many of the recurring clinical themes of the USMLE Step 1. The information presented in this text prepares you to handle not only the clinical vignettes found on the USMLE Step 1, but also the questions concerning basic gross anatomy concepts"--Provided by publisher.
Contents:
1. Vertebral column
2. Spinal cord and spinal nerves
3. Autonomic nervous system
4. Lymphatic System
5. Chest wall
6. Pleura, tracheobronchial tree, lungs
7. The heart
8. Abdominal wall
9. Peritoneal cavity
10. Abdominal vasculature
11. Abdominal viscera
12. Sgmod colon, rectum, and anal canal
13. Spleen
14. Kidney, ureter, bladder, and urethra
15. Suprarenal (adrenal)
16. Female reproductive system
17. Male reproductive system
18. Pelvis
19. Perineum
20. Upper limb
21. Lower limb
22. Head
23. Neck
24. Eye
25. Ear
Appendices
Credits
Index. - PrintDouglas J. Gould, PhD, Professor and Vice Chair, Department of Biomedical Sciences, William Beaumont School of Medicine, Oakland University, Rochester, Michigan, Jennifer K. Brueckner-Collins, PhD, Professor and Vice- Chair, Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky ; author of first-fourth editions James D. Fix (1931-2010).Summary: Now significantly revised based on student feedback, this best-selling text provides a quick, authoritative review of the most important clinical aspects of neuroanatomy. A new, full-color design highlights the essential information you need to know to excel on course exams and the USMLE Step 1. New objectives begin every chapter, contents have been reorganized and streamlined, and all information has been completely updated. A new Gross Structure chapter lays the foundation for understanding the sectional anatomy in the Atlas chapter, and all terminology is now consistent with Terminologia Anatomica.
Contents:
Machine generated contents note: 1. Gross Structure Of The Brain
I. Divisions of the Brain
2. Development Of The Nervous System
I. The Neural Tube
II. The Neural Crest
III. The Cranial Neuropore
IV. The Caudal Neuropore
V. Microglia
VI. Myelination
VII. The Optic Nerve and Chiasma
VIII. The Hypophysis (pituitary gland)
IX. Congenital Malformations of the CNS
3. Neurohistology
I. Neurons
II. Nissl Substance
III. Axonal Transport
IV. Anterograde (Wallerian) Degeneration
V. Chromatolysis
VI. Regeneration of Nerve Cells
VII. Neuroglia
VIII. The Blood-Brain Barrier
IX. The Blood-CSF Barrier
X. Pigments and Inclusions
XI. Classification of Nerve Fibers
XII. Tumors of the CNS and PNS
XIII. Cutaneous Receptors
4. Blood Supply
I. The Spinal Cord and Caudal Brainstem
II. The Internal Carotid System
III. The Vertebrobasilar System
IV. The Blood Supply of the Internal Capsule
V. Veins of the Brain
VI. Venous Dural Sinuses. Note continued: VII. Angiography
VIII. The Middle Meningeal Artery
5. Meninges, Ventricles, And Cerebrospinal Fluid
I. Meninges
II. Ventricular System
III. Cerebrospinal Fluid
IV. Herniation
6. Spinal Cord
I. Gray and White Rami Communicans
II. Spinal Nerves
III. Conus Medullaris
IV. Location of the Major Motor and Sensory Nuclei of the Spinal Cord
V. The Cauda Equina
VI. The Myotatic Reflex
Case 6
1
I. Posterior (Dorsal) Column
Medial Lemniscus Pathway
II. Anterolateral System
III. Lateral Corticospinal Tract
Case 6
2
I. Diseases of the Motor Neurons and Corticospinal Tracts
II. Sensory Pathway Lesions
III.Combined Motor and Sensory Lesions
IV. Peripheral Nervous System (PNS) Lesions
V. Intervertebral Disk Herniation
VI. Cauda Equina Syndrome (Spinal Roots L3 to CO)
VII. Conus Medullaris Syndrome (Cord Segments S3 to C0)
7. Brainstem
I. Introduction
II. Cross Section Through the Caudal Medulla. Note continued: III. Cross Section Through the Mid-Medulla
IV. Cross Section Through the Rostral Medulla
V. Cross Section Through the Caudal Pons
VI. Cross Section Through the Mid-Pons
VII. Cross Section Through the Rostral Pons
VIII. Cross Section Through the Caudal Midbrain
IX. Cross Section Through the Rostral Medulla
X. Corticonuclear Fibers
Lesions of the Brainstem
I. Lesions of the Medulla
II. Lesions of the Pons
III. Lesions of the Midbrain
IV. Acoustic Neuroma (Schwannoma)
V. Jugular Foramen Syndrome
VI."Locked-in" Syndrome
VII. Central Pontine Myelolysis
VIII."Top of the Basilar" Syndrome
IX. Subclavian Steal Syndrome
X. The Cerebellopontine Angle
8. Autonomic Nervous System
I. Introduction
II. Cranial Nerves (CN) With Parasympathetic Components
III.Communicating Rami
IV. Neurotransmitters
V. Clinical Correlation
9. Cranial Nerves
I. The Olfactory Nerve
II. The Optic Nerve (CN II). Note continued: III. The Oculomotor Nerve (CN III)
IV. The Trochlear Nerve (CN IV)
V. The Trigeminal Nerve (CN V)
VI. The Abducent Nerve (CN VI)
VII. The Facial Nerve (CN VII)
VIII. The Vestibulocochlear Nerve (CN VIII)
IX. The Glossopharyngeal Nerve (CN IX)
X. The Vagal Nerve (CN X)
XI. The Accessory Nerve (CN XI)
XII. The Hypoglossal Nerve (CN XII)
10. Trigeminal System
I. Introduction
II. The Trigeminal Ganglion
III. Trigeminothalamic Pathways
IV. Trigeminal Reflexes
V. The Cavernous Sinus
11. Diencephalon
I. Introduction
II. The Thalamus
III. Blood Supply
IV. The Internal Capsule
V. The hypothalamus
12. Auditory System
I. Introduction
II. The Auditory Pathway
III. Hearing Defects
IV. Auditory Tests
13. Vestibular System
I. Introduction
II. The Labyrinth
III. The Vestibular Pathways
IV. Vestibulo-ocular Reflexes
14. Visual System
I. Introduction
II. The Visual Pathway. Note continued: III. The Pupillary Light Reflex Pathway
IV. The Pupillary Dilation Pathway
V. The Near Reflex and Accommodation Pathway
VI. Cortical and Subcortical Centers for Ocular Motility
VII. Clinical Correlation
15. Limbic System
I. Introduction
II. Major Components
III. The Papez Circuit
IV. Clinical Correlations
16. Basal Nuclei And Extrapyramidal Motor System
I. Basal Nuclei (Ganglia)
II. The Extrapyramidal (Striatal) Motor System
III. Clinical Correlation
17. Cerebellum
I. Function
II. Anatomy
III. The Deep Cerebellar Nuclei
IV. The Major Cerebellar Circuit
V. Cerebellar Dysfunction
VI. Cerebellar Syndromes and Tumors
18. Cerebral Cortex
I. Introduction
II. The Six-Layered Neocortex
III. Functional Areas
IV. Focal Destructive Hemispheric Lesions and Symptoms
V. Cerebral Dominance
VI. Split Brain Syndrome
VII. Other Lesions of the Corpus Callosum
VIII. Brain and Spinal Cord Tumors
IX. Apraxia. Note continued: X. Aphasia
XI. Dysprosodies
19. Cross-Sectional Anatomy Of The Brain
I. Introduction
20. Neurotransmitters
I. Major Neurotransmitters
II. Functional and Clinical Considerations. - DigitalGanga Ram Regmi, Falk Huettmann, editors.Summary: This book describes the myriad components of the Hindu Kush-Himalaya (HKH) region. The contributors elaborate on challenges, failures, and successes in efforts to conserve the HKH, its indigenous plants and animals, and the watershed that runs from the very roof of the planet via world-rivers to marine estuaries, supporting a human population of some two billion people. Readers will learn how the landforms, animal species and humans of this globally fascinating region are connected, and understand why runoff from snow and ice in the world's tallest mountains is vital to inhabitants far downstream. The book comprises forty-five chapters organized in five parts. The first section, Landscapes, introduces the mountainous watersheds of the HKH, its weather systems, forests, and the 18 major rivers whose headwaters are here. The second part explores concepts, cultures, and religions, including ethnobiology and indigenous regimes, two thousand years of religious tradition, and the history of scientific and research expeditions. Part Three discusses policy, wildlife conservation management, habitat and biodiversity data, as well as the interaction of animals and humans. The fourth part examines the consequences of development and globalization, from hydrodams, to roads and railroads, to poaching and illegal wildlife trade. This section includes studies of animal species including river dolphins, woodpeckers and hornbills, langurs, snow leopards and more. The concluding section offers perspectives and templates for conservation, sustainability and stability in the HKH, including citizen-science projects and a future challenged by climate change, growing human population, and global conservation decay. A large assemblage of field and landscape photos, combined with eye-witness accounts, presents a 50-year local and wider perspective on the HKH. Also included are advanced digital topics: data sharing, open access, metadata, web portal databases, geographic information systems (GIS) software and machine learning, and data mining concepts all relevant to a modern scientific understanding and sustainable management of the Hindu Kush-Himalaya region. This work is written for scholars, landscape ecologists, naturalists and researchers alike, and it can be especially well-suited for those readers who want to learn in a more holistic fashion about the latest conservation issues.
Contents:
Preface
Part 1. Landscapes
1. Mountain Landscapes and Watersheds of the Hindu Kush-Himalaya (HKH) and Their Biogeography: A Descriptive Overview and Introduction for 18 Nations in the Anthropocene
2. The Hindu Kush-Himalaya (HKH) Region in the Modern Global and Climate Context: Major Weather Systems, Monsoon, Asian Brown Clouds (ABCs), Digital Data/Models and Global Linkages of Telecoupling and Teleconnection all Affecting Global Human Well
3. From the Mountains and Glaciers Down to the Rivers to the Estuaries and Oceans: Another Sad Tale of 18 or so Rivers
4. The Hindu Kush-Himalaya (HKH) in the Global and Marine Context: Major Estuaries, Coast-Scapes, Ocean Coupling, Seawalls, over 2 Billion People and Global (Food) Security
5. A View from Space on Poyang Lake: What We Can Already See and What It Means
6. Effective Poyang Lake Conservation? A Local Ecology View from Downstream Involving Internationally Migratory Birds When Trying to Buffer and Manage Water from HKH with 'Modern' Concepts
7. The Future of Biodiversity in the Changing Watersheds of Kashmir Himalaya, Pakistan: Conservation Challenges and Opportunities 15. Settling the Terror of Your Mind with the Deities: About Fear, Anxiety, Inherent Chaos and Self-Doubt in Hind Kush-Himalaya Expeditions and Associated Research
Part 3. Real-World Policy, Conservation Management of Wildlife, Habitat, and Biodiversity Data
16. The Relevance and Significant Role of Mid-elevation for the Watersheds and Biodiversity Conservation in the Hindu Kush-Himalaya: The Case of Nepal in the Anthropocene
17. Nature and Landscape Governance in Royal Times: Experiences from the Shah and Rana Regimes in Nepal Re-assembled from Literature and Interview Data
18. Swallows and Sparrows in the Human Street-Market Interface of Urban Nepal: Towards a First Open Access GIS Data and Model Inference on the Role of Religion and Culture in Bird Distribution
19. Pallas's Cat in Annapurna, Nepal: What We Know Thus Far and What Is to Come
20. Status of Otters in Nepal: A Link with Ancient Waterways and People
21. Wildlife Diplomacy and Gifting in the Hindu Kush-Himalaya Region: A Chronological History and Opinion of Nepalese Literates
22. Birds of Nepal: Their Status and Conservation Especially with Regards to Watershed Perspectives 23. A Governance Analysis of the Snow Leopard, Its Habitat and (Digital) Data: Who Owns Charismatic Animals and Who Drives and Uses the Agenda for What?
24. The Annapurna Conservation Area Project (ACAP): Towards a Success Story in Landscape Feature and Watershed Conservation Management
25. The Forgotten Data: A Rather Short but Deep Story of Museums and Libraries in HKH and Similar Information Sources in Support of the Global Biodiversity Information System (GBIF.org) and Model-Predictions for Improved Conservation Management
26. A Rather Short Story of Shared GIS Data Layers in the Hindu Kush-Himalayas: State of the Art, Justifications and Urgent Suggestions for a Sustainable Global Data Governance with Open Access and Open Source Coming to the Rescue
27. Insect Pollinators, Threats For Survival and Ecosystem Service: An Outlook From Hindu-Kush Himalaya Region
28. A First High-Resolution Open Access Data and Open Source GIS Model-Prediction for the Globally Threatened Sarus Crane (Antigone antigone) in Nepal: Data Mining of 81 Predictors Support Evidence for Ongoing Declines in Distribution and Abunda
Part 4. A Fresh Look and Successful Templates for HKH: 'Business as Usual' Is Dead 39. Small and Effective NGOs as a Role Model for Bigger Success: The Global Primate Network (Now 'Third Pole Conservancy')
40. When Micro Drives the Macro: A Fresh Look at Disease and its Massive Contributions in the Hindu Kush-Himalaya
41. Water in Mongolia: Sources, Uses and Issues, with Special Emphasis on Mining
42. Good Citizen Science Experience Downstream of Everest Helps Monitor Status of Wetland Birds
43. A Citizen Science Experience: Green Youth of Lumbini (GYL) Promoting Globally Threatened Bird Species (Cranes/Storks) and Holistic Landscape Conservation in the Lumbini Region of Nepal, on the Ground as well as with Social Media
44. When Governments Cannot Do It Anymore and When Capitalism, Neoliberal Policies and Globalization Get Imposed Without Democracy: Self-Organization in the HKH Region Beyond E. Ostrom and Facebook
45. Quo Vadis HKH? 'Sustainable Development' as a Horror Scenario while Climate Change, Human Population Increase and Global Conservation Decay are on the Rise Further
Index. 8. Towards a Landscape Perspective of Diseases in Plants: An Overview and Review of a Critical but Overlooked Ecology Issue in the Hindu Kush-Himalayan Region
9. Showing True Change of the Hindu Kush Himalaya Region Through the Power of Photo Monitoring as a Visual Memory of Change
10. A First-Hand Narrative Account on Tibet's Paper Parks: How China's Greenwashing in Tibet Flies Under the Radar
11. Forestry Management in Nepal: An Example and a Review of Growth & Yield
Part 2. Concepts, Cultures, Religions and the Mind
12. What It Is Like to Be a Land-Locked Nation: Some Discriminatory Examples and Details from National Watersheds of the Hindu Kush-Himalaya Under the Neoliberal 'Free Market' Participation Paradigm
13. Ethnobiology and Indigenous Regimes in the Conservation of Species, Watersheds, and Landscapes: Experiences and Evidences from the Hindu Kush-Himalayan Nations for a Global Application
14. Spirituality Beats It All: A Quick Conservation Overview, Self-Organization and the Great Value of (Indigenous) Religions for Hindu Kush-Himalaya Landscapes, Its Geo-Parks, Species, Ecological Processes and Watersheds - Digital[edited by] Joseph A. Smith, Jr., Stuart S. Howards, Glenn M. Preminger, Roger R. Dmochowski.Contents:
Surgical basics
Suture techniques
Reconstructive techniques
Bowel stapling and closure techniques
Methods of nerve block
Basic laparoscopy
Basics of robotic surgery
Surgical approaches for open renal surgery, including open radical nephrectomy
Open partial nephrectomy
Open and laparoscopic nephroureterectomy
Vena caval thrombectomy
Laparoscopic nephrectomy
Laparoscopic and robotic-assisted laparoscopic partial nephrectomy
Percutaneous resection of upper tract urothelial carcinoma
Open pyeloplasty
Surgery of the horseshoe kidney
Repair of renal injuries
Surgery for renal vascular disease and principles of vascular repair
Renal transplant recipient
Endoscopic management of ureteral strictures
Percutaneous endopyeloplasty
Laparoscopic and robotic pyeloplasty
Laparoscopic live donor nephrectomy
Open stone surgery : anatrophic nephrolithotomy and pyelolithotomy
Anatomic basis for renal endoscopy
Percutaneous renal access
Percutaneous nephrolithotomy
Laparoscopic access
Renal cryosurgery
Renal radiofrequency ablation
Robotic, laparoscopic, and open approaches to the adrenal gland (benign)
Open and laparoscopic approaches to the adrenal gland (malignant)
Ureteroneocystostomy
Bladder flap repair (Boari)
Ureteral stricture repair and ureterolysis
Ureteroureterostomy and transureteroureterostomy
Ileal ureteral replacement
Ureterolithotomy
Endoscopic management of vesicoureteral reflux
Ureteroscopic instrumentation
Ureteroscopic management of ureteral calculi
Ureteroscopic management of renal calculi
Ureteroscopic endopyelotomy and endoureterotomy
Ureteroscopic management of upper tract urothelial carcinoma
Endoscopic incision of ureteroceles
Transurethral resection of bladder tumors
Partial cystectomy
Radical cystectomy in male patients
Radical cystectomy in female patients
Urethrectomy
Pelvic lymphadenectomy
Excision of vesical diverticulum
Cystolithotomy
Laparoscopic/robotic radical cystectomy
Ileocecal reservoir
Appendicovesicostomy
Ureterosigmoidostomy and mainz pouch ii
Ileal orthotopic bladder substitution
Robotic urinary diversion
Ileocystoplasty
Colocystoplasty
Ureterocystoplasty
Transvaginal repair of vesicovaginal fistula
Transvesical repair of vesicovaginal fistula
Transperitoneal vesicovaginal fistula repair
Female vesical neck closure
Transurethral resection and transurethral incision of the prostate
Laser treatment of benign prostatic disease
Suprapubic prostatectomy
Retropubic prostatectomy
Laparoscopic and robotic simple prostatectomy
Anatomy and principles of excision of the prostate
Transrectal ultrasound-directed prostate biopsy
Transperineal prostate biopsy
Prostate biopsy with MR fusion
Radical retropubic prostatectomy
Radical perineal prostatectomy
Pelvic lymph node dissection
Robotic-assisted laparoscopic prostatectomy
Cryotherapy
Focal therapies in the treatment of prostate cancer
Brachytherapy
Vaginal reconstruction
Urethrovaginal fistula repair
Bulbocavernosus muscle and fat pad supplement
Female urethral diverticulum
Female urethral reconstruction
Urethral prolapse-caruncle
Anterior pelvic organ prolapse repair
Enterocele repair
Rectocele repair
Reconstruction of the fossa navicularis
Reconstruction of strictures of the penile urethra
Reconstruction of strictures of the bulbar urethra
Reconstruction of pelvic fracture urethral distraction defect
York--mason closure of rectourinary fistula in the male
Direct vision internal urethrotomy
Autologous pubovaginal sling
Tension-free vaginal tape/suprapubic midurethral sling
Transobturator midurethral sling
Bulking agents for incontinence
Artificial urinary sphincter
Male urethral sling
Neuromodulation
Botox injection for urologic conditions
Testis biopsy
Sperm retrieval
Varicocele ligation
Simple orchiectomy
Vasectomy
Vasovasostomy and vasoepididymostomy
Spermatocelectomy
Epididymectomy
Undescended testis
Reduction of testicular torsion
Testis-sparing surgery for benign and malignant tumors
Radical orchiectomy
Retroperitoneal lymph node dissection
Laparoscopic and robotic retroperitoneal lymph node dissection
Circumcision and dorsal slit or preputioplasty circumcision
Penile curvature in pediatric patients
Hidden penis
Insertion of semirigid penile prostheses
Inflatable penile prosthesis implantation
Penile arterial revascularization
Procedures for peyronie disease
Operations for priapism
Repair of genital injuries
Pediatric meatotomy and distal reconstruction
Repair of proximal hypospadias
Partial penectomy
Total penectomy
Ilioinguinal lymphadenectomy
Laser treatment of the penis.Digital Access ClinicalKey 2018 - Digital[edited by] Daniel J. Berry, William J. Maloney.Contents:
pt. I Surgical Approaches
ch. 1 Anterior Approach Total Hip Arthroplasty / Michael Taunton
ch. 2 The Direct Lateral Approach for Total Hip Arthroplasty / Stuart B. Goodman
ch. 3 Posterolateral Approach (Including Minimally Invasive Variations) / James I. Huddleston
ch. 4 Conventional Trochanteric Osteotomies and the Trochanteric Slide / Andrew H. Glassman
pt. II Nonarthroplasty Approaches
ch. 5 Extended Trochanteric Osteotomy / Wayne G. Paprosky
ch. 6 Hip Arthroscopy for Nonstructural Pathology / Elizabeth Ford
ch. 7 Arthroscopy for Structural Hip Problems / Bruce A. Levy
ch. 8 Head-Sparing Procedures for Osteonecrosis of the Femoral Head / Michael A. Mont
ch. 9 Periacetabular Osteotomy and Femoral Osteotomy / John C. Clohisy
ch. 10 Hip Arthrodesis / Clive Duncan
pt. III Primary Total Hip Arthroplasty
ch. 11 Principles, Planning, and Decision Making / Young-Min Kwon
ch. 12 Cemented Acetabular Component in Total Hip Arthroplasty / Andrew John Timperley
ch. 13 The Uncemented Socket / John C. Clohisy
ch. 14 The Polished Tapered Cemented Stem / Jonathan R. Howell
ch. 15 Extensively Coated Stems / C. Anderson Engh Jr.
ch. 16 The Tapered Stem / William J. Hozack
ch. 17 Double-Tapered Primary Stems / Thomas P. Schmalzried
ch. 18 Modular Stems / David A. Mattingly
pt. IV Complex Primary Total Hip Arthroplasty
ch. 19 Techniques for DDH Cup and Femur / Steven J. MacDonald
ch. 20 Total Hip Arthroplasty in Patients with Proximal Femoral Deformity / Daniel J. Berry
pt. V Revision Total Hip Arthroplasty
ch. 21 Principles, Planning, and Decision Making / Nicholas J. Giori
ch. 22 Component Removal / Rafael J. Sierra
ch. 23 Uncemented Acetabular Revision with Hemispherical Cups / Erdan Kayupov
ch. 24 Uncemented Acetabular Revision with Metal Augments or Cup-Cage Combinations / David G. Lewallen
ch. 25 Custom Triflanged Devices in the Revision Acetabulum / Douglas A. Dennis
ch. 26 Cemented Stems, Impaction Grafting, and Cement in Cement Revision / Donald William Howie
ch. 27 Extensively Porous-Coated Cylindrical Uncemented Femoral Stems / Scott M. Sporer
ch. 28 Tapered Fluted Titanium Stems in Revision Total Hip Arthroplasty / Donald S. Garbuz
ch. 29 Allograft Prosthetic Composite and Endoprosthetic Replacement of the Proximal Femur / Chris Beauchamp
pt. VI Special Revision Techniques
ch. 30 Techniques to Manage Infection around Total Hip Arthroplasty and Antibiotic-Loaded Spacers for Infection / Bassam A. Masri
ch. 31 Techniques to Manage Osteolysis Around Well-Fixed Acetabular Components / William J. Maloney.Digital Access - DigitalMarc Safran, Mustafa Karahan, editors.Summary: This book presents the latest knowledge in the evaluation and management of hip- and groin-related injuries in athletes. Techniques of hip arthroscopy, as well as their limitations and possible complications, are clearly described, and guidance is provided on the use of periarticular hip endoscopy in patients with periarticular problems. A series of chapters address the potential approaches in the various conditions that may be encountered in athletes, including femoroacetabular impingement, athletic pubalgia, chondral and labral injuries, and hip instability by world renowned experts in the field. Considerations in particular age groups, especially adolescents, are highlighted. Rehabilitation is discussed in detail, and a concluding chapter examines emerging perspectives on the management of hip injuries. The book is published in collaboration with ISAKOS and combines the international expertise of ISAKOS members renowned for their management of injuries to the hip and groin. Hip and Groin Pain in the Athlete will be a must-read for team physicians and all clinicians who treat athletes.
Contents:
Physical Examination and Imaging of the Painful Athletic Hip
Portal Anatomy and Patient Positioning
Hip Arthroscopy: Anatomy and Techniques
Endoscopic Peritrochanteric Space: Evaluation and Treatment
Clinical Examination and Diagnosis of Extra-Articular Hip and Groin Pain
Muscular Function and Treatment of Musculotendinous Groin Pain
Surgical Dislocation for FAI in Athletes
Arthroscopic Management of Femoroacetabular Impingement in Athletes
Arthroscopic Management of Chondral and Labral Injuries
Hip Instability in the Athlete
Special Issues Related to Hip Pain in the Adolescent Athlete
Hip Dysplasia in Athletes
Complications Related to the Arthroscopic Treatment of the Femoroacetabular Impingement
Hip Arthroscopy: What Are the Limitations
Rehabilitation Following Hip Arthroscopy: Takla-O’Donnell Protocol (TOP) for Physical Therapy
Future of Hip Arthroscopy in the Management of the Athlete’s Hip - DigitalPeter H. Seidenberg, Jimmy D. Bowen, David J. King, editors.Summary: Now in a revised and updated second edition, this practical guide remains an invaluable resource for improving the management of hip and pelvis injuries and presents a spectrum of treatment options for children, adolescents, adults and special populations. Opening with valuable clinical pearls for each topic, differential diagnosis is emphasized throughout the chapters, and evidence-based guidelines and sport-specific considerations aid the reader with injury evaluation and care. From fundamentals--including epidemiology, history and physical examination, imaging and gait assessment--to functional therapeutic interventions, injection techniques, taping and bracing, and both surgical and non-surgical interventions, The Hip and Pelvis in Sports Medicine and Primary Care, Second Edition is ideal for sports medicine physicians, primary care physicians, physical therapists and athletic trainers alike.Digital Access Springer 2017
- DigitalShane J. Nho, Michael Leunig, Christopher M. Larson, Asheesh Bedi, Bryan T. Kelly, editorsSummary: Hip pathology and nonarthritic hip conditions have only recently been recognized as a cause of hip pain. In 2003, Ganz, Leunig and colleagues described the concept of femoroacetabular impingement (FAI) as a cause of hip pain and a mechanism for end-stage hip osteoarthritis.Ganz et al. also postulated that 70-90% of hip osteoarthritis is likely due to abnormal hip mechanics related to FAI, dysplasia, or other hip deformities. Over the past ten years, the treatment of these non-arthritic hip pathologies has grown dramatically, and has been estimated to grow by 15% each year. It is the largest segment of grown in sports medicine and orthopedics as a whole. However, no definitive reference yet exists on hip arthroscopy and hip joint preservation surgery. While books have been published on hip arthroscopy, these texts are limited to the technical aspects of the procedure and do not explore content related to hip joint preservation surgery. The scope of this book covers the basic science of hip pathology, anatomy, biomechanics, pathology, and treatment.℗ℓ It has put together up-to-date research and has invited opinion leaders in the field to contribute to the text. The book is focused on disease pathology and provides comprehensive information on each disease topic, which is followed by technique-driven chapters to provide surgeons a reference for any procedure related to non-arthritic conditions of the hip.
- DigitalShane J. Nho, Asheesh Bedi, Michael J. Salata, Richard C. Mather III, Bryan T. Kelly, editors.Summary: The field of hip preservation surgery has evolved over the past decade as our understanding of hip pathomechanics and pathomorphology has expanded. The published literature on non-arthritic hip pathology, for example, has grown exponentially. The topics of controversy in the past decade have been answered in some cases, but new questions have also arisen. In addition to the 99 chapters in the original edition most of which will be retained and updated as applicable there will be over 30 brand new chapters focusing on new and more sophisticated techniques from authors that have been the pioneers of the field. The text is divided into nine thematic sections, covering the breadth of the topic and the current state of the art: basic science of the hip; operative basics for hip arthroscopy and open hip preservation surgery; pediatric hip conditions; approaches to disorders of the hip and pelvis; enthesopathy and neuromuscular disorders; hip fractures and instability; avascular necrosis; hip cartilage restoration; and oncologic conditions. Throughout, there is a heavy emphasis on surgical techniques, and video clips will be included in selected chapters. Written by edited by thought leaders and seasoned practitioners in the field, this new edition of Hip Arthroscopy and Hip Joint Preservation Surgery will remain the gold standard for orthopedic surgeons and sports medicine specialists, expanding on the range of techniques available to clinicians treating injuries to and disorders of the hip.
- DigitalPaul E. Beaulé, editor.Summary: This book represents the most advanced understanding of diagnosis and management of hip dysplasia in the young adult, written by the worlds leading experts and covering advanced imaging and biomechanical studies as well as latest surgical techniques. This is especially timely, as the field of hip preservation surgery is in constant evolution, and it is critical that surgeons and researchers combine their efforts to provide the best evidence-based knowledge to all health care providers evaluating and treating patients suffering from pre-arthritic hip pain. Not only does this book discuss the most up-to-date information on the etiology and natural history of hip dysplasia, as well as pathomechanics and traditional and advanced imaging, it also presents new conceptions of its classification and subsequent management. The focus throughout the book is that hip dysplasia is a problem of instability, where both the bony structure and the soft tissue envelope (i.e., capsule, ligaments and muscles) are at play. Moreover, although corrective osteotomies such as the peri-acetabular osteotomy will remain the dominant treatment option, non-surgical treatments as well as hip arthroscopy are now being increasingly recognized as useful adjuncts in order for our patients to return to their desired activities. Finally, as the longevity of joint replacement surgery has improved dramatically, this should be strongly considered in cases where the outcome of joint preserving surgery is not as predictable. Orthopedic surgeons, sports medicine physicians, physiatrists and physiotherapists alike will find this book a valuable resource when treating the young adult with symptomatic hip dysplasia.
Contents:
Etiology of Hip Dysplasia
Natural History of Residual Hip Dysplasia
Anatomical Description-Classification of Hip Dysplasia
Pathomechanics of the Dysplastic Hip
Biomechanics of the Native Hip from Normal to Instability
Traditional Imaging
Advancing Imaging of the Hip
Non-Surgical Management of Pre-Arthritic Dysplastic Hip Pain
Adjuvant Therapies in the Treatment of Pre-Arthritic Hip Disease
Role and Indications of Hip Arthroscopy for Hip Dysplasia
Proximal Femoral Osteotomy
The Periacetabular Osteotomy
Other Pelvic Osteotomies
Joint Replacement in the Dysplastic Patient.Digital Access Springer 2020 - DigitalJoseph C. McCarthy, Philip C. Noble, Richard N. Villar, editors.Summary: Hip Joint Restoration is a comprehensive yet practical guide to the basic science and clinical applications of arthroscopy, arthroplasty, osteotomy and preservation surgery for the treatment of diseases and conditions of the hip. This generously illustrated text offers a comprehensive introduction to essential features of hip evaluation, the medical management of hip procedures, and treatment of specific conditions, and covers practical topics such as surgical anatomy of the hip, surgical approaches, instrumentation, and indications for arthroscopy and other surgical procedures aimed at restoration of the hip joint. Additional chapters cover clinical outcomes and equality of life following hip surgery, the current state of research and education of arthroscopic hip procedures throughout the world, other topics such as complications and rehabilitation in different patient populations. This book will be a useful resource for Orthopedic Surgeons and Osteopaths who perform open and arthroscopic hip preservation and total joint replacement, as well as for orthopedic residents and researchers. .
Contents:
Part One: Structure and Function of the Tissues of the Hip (Normal and Diseased)
Development of the Hip: Phylogeny and Ontogeny
Anatomy
Cartilage
Anatomy
Labrum
Anatomy
Capsule and Synovium
Fundamental and Clinical Considerations of the Muscles of the Hip
Ligamentum Teres: Anatomy, Structure and Function
Functional Mechanics of the Human Hip
Part Two: Clinical Evaluation of Hip Function
Function of the Normal Hip
Outcome Instruments for Assessment of Hip Function
Gait Analysis
Evaluation of the Painful Hip
Clinical Evaluation of Hip Function
Essential Features in the History
Essential Findings in the Clinical Exam
Part Three: Hip Pathology
Osteoarthritis of the Hip
Hip Disease Etiologies: FAI and Dysmorphias
Synovial Pathology of the Hip
Hip Pathology
Overload Syndromes
Hip Disease Etiologies
Trauma
The Understanding of Hip Etiologies
Osteonecrosis of the Femoral Head
Part Four: Imaging Advances
The Bony Morphology of Femoro-Acetabular Impingement
Imaging of Cartilage Patho-Anatomy
Magnetic Resonance Imaging of the Hip Labrum, Capsule and Synovium
Extra-Articular Pathology of the Hip
Magnetic Resonance Imaging of the Hip
Imaging the Previously Operated Hip
Advances in 2D and 3D Imaging for FAI Surgical Planning
Part Five: Non Arthroscopic Treatment of Hip Disease
The Natural History of Untreated Osteoarthritis of the Hip
Non-Surgical Treatment (Indications, Limitations, Outcomes)
Injections
Groin Pain in Athletes: Assessment and Non-Surgical Treatment
The Painful Groin
Limited Open Procedures
Limitations of Open and Arthroscopic Surgical Technique for the Treatment of Femoroacetabular Impingement
Open Surgical Treatment -Advantages and Complications of Modern Surgical Approaches
Part Six: Arthroscopic Treatment of Hip Disease
The History of Hip Arthroscopy
Indications for Hip Arthroscopy
Arthroscopic Treatment -Surgical Anatomy
Hip Arthroscopy: Anatomy and Technical Pearls of the Procedure
Arthroscopic Treatment
Principles of Hip Distraction
Arthroscopic Treatment
Fundamentals of Hip Joint Instrumentation
Arthroscopic Treatment
Principles and Devices for Hip Joint Access
Arthroscopic Treatment- Layout of the Operating Room Surgical Approaches-Lateral
Arthroscopic Treatment
Layout of the Operating Room- Surgical Approaches-Supine
Optimizing Exposure and Accessibility for Arthroscopic Correction of Femoroacetabular Impingement
Anesthesia and Analgesia for Hip Surgery
Part Seven: Surgical Treatment of Specific Hip Conditions
Biologic Labrum
Specific Tissues and Conditions
Chondral Lesions
Special Patients and Conditions
Femoro- Acetabular Impingement
Arthroscopic Treatment of Combined Cam and Pincer-type Femoroacetabular Impingement
Special Patients & Conditions: Other Forms of Impingement (Ischiofemoral, Pectineofoveal)
Synovial Disease
Surgical Treatment of Specific Hip Conditions: Ligamentum Teres Injuries
Treatment of Specific Conditions: Loose Bodies
Specific Tissues and Conditions
Trauma
Arthroscopic Treatment- Bony Lesions
Specific Tissues and Conditions
Osteonecrosis, Avascular Necrosis
Specific Tissues and Conditions
Pediatric Conditions
Specific Tissues and Conditions
Extra-Articular Pathologic Conditions
Part Eight: Special Patients and Conditions
Elite Athletes
Special Patients and Conditions
Capsular Laxity Including Ehlers-Danlos
Current Procedures and Techniques for the Treatment of Osteonecrosis of the Hip
Special Patients and Conditions
Sports Hernia
Acetabular Dysplasia: A Classification
Quality-of-Life after Hip Arthroscopic Surgery
Evaluating the Outcome of Hip Preserving Procedures: Patient Function, Satisfaction, and Impairment
Part Nine: Articular Lesions: Prevention and Treatment
Biology of Cartilage Regeneration
Microfracture in the Hip
Cartilage Grafting
The Use of Fibrin Adhesive for Cartilage Repair in Hip Arthroscopy
Novel Techniques in the Treatment of Chondral Lesions of the Hip
Osteochondral Allografting of the Hip
Part Ten: Hip Osteotomies
Special Patients and Conditions
Acetabular Dysplasia
Hip Osteotomies
Acetabular
Birmingham Interlocking Periacetabular Osteotomy
Mini-Incision Periacetabular Osteotomy
Results of Periacetabular Osteotomy (PAO)
Proximal Femoral Osteotomy in Hip Preservation
Combined Periacetabular Osteotomy and Proximal Femoral Osteotomy for Severe Hip Deformity
Part Eleven: Joint Replacement
Partial Joint Replacement
Metal on Metal Hip Resurfacing: Current Indications and Results
Total Hip Replacement in the Young Patient
Short Stem Total Hip Replacement
Hip Replacement in the Athlete
Arthroscopy Following Total Hip Replacement
Part Twelve: Functional Outcomes
Activities, Symptoms and Expectations of Patients Undergoing Hip Surgery
Rehabilitation after Hip Arthroscopy
The Importance of Validated Scoring Systems for the Hip
Survivorship and Clinical Results after Hip Arthroscopy: How Should We Define a Good Treatment Option?
Part Thirteen: Worldwide Experience with Hip Arthroscopy
UK and European Experience with Hip Arthroscopy
Africa
History of Hip Arthroscopy in the United States
Worldwide Experience with Hip Arthroscopy
Australia
Worldwide Experience of Hip Arthroscopy: Mexican Experience
Worldwide Experience with Hip Arthroscopy: South America
Hip Arthroscopy in India: A Perspective
The Worldwide Experience with Hip Arthroscopy
Japan
Hip Arthroscopy in China
Part Fourteen: Practice Management and Education
Setting Up a Hip Arthroscopy Service
Education and Hip Arthroscopy
Part Fifteen: Research
Development Anatomy and Its Impact on Hip Function
Research Advances in Understanding the Genetic Basis of Hip Disease
Fluid Mechanics Pre and Post Capsulotomy
Research into the Application of Imaging to the Diagnosis of Hip Disease
Cell Therapy in Hip Surgery
Surgical Navigation of the Hip for Femoroacetabular Impingement
Outcomes Following Hip Surgery
The Critical Role of Registries in Documenting the Outcomes of Hip Preservation Surgery
Part Sixteen: The Critical Role of Registries in Documenting the Outcomes of Hip Preservation
The Future of Hip Arthroscopy>.Digital Access Springer 2017 - DigitalYoung-Jo Kim, Tallal Charles Mamisch, editors.Summary: Hip Magnetic Resonance Imaging presents a basic yet comprehensive discussion of the role and use of MRI in the diagnosis and treatment of injuries and diseases of the hip, highlighting common concerns and procedures. Beginning with the principles of MRI and dGEMRIC and moving on to normal and abnormal hip anatomy, the focus shifts to the MRI techniques used in the detection of disease conditions of the hip, including labral disease, osteonecrosis, extra-articular conditions and cartilage damage. Chapters on the utilization of biochemical imaging biomarkers in the treatment of hip disorders round out the text. Written by experts in radiology and orthopedics and generously illustrated with MRI radiographs, this book will be an important reference work for clinicians in those fields, as well as practitioners of sports medicine and primary care physicians.
Contents:
Part I: MRI Principles
Basic MRI Physics and Artifacts
Non-contrast Biochemical Imaging
Delayed Gadolinium Enhanced MRI of Cartilage
Clinical Application of Biochemical Imaging of Cartilage
Part II: Hip Joint Anatomy and Diseases
Normal Articular Anatomy
Abnormal Osseous Anatomy
Abnormal Articular Anatomy
Developmental Hip Disorders
Extra-articular Hip Conditions and Sports Injuries
Part III: MRI Techniques to Detect Disease Conditions
Overview of Diagnostic Imaging of Hip Joint
Labral Disease
Osteonecrosis
Extra-articular Conditions
Cartilage Damage
Structural Assessment
Part IV: Utilization of Biochemical Imaging Biomarkers in Treatment of Hip Disorders
Application of dGEMRIC to the Study of Hip Disorders
Application of T1rho to the Hip. - DigitalNicolas Bonin, Filippo Randelli, Vikas Khanduja, editors.Summary: This book offers practical guidance on all procedures that may be performed within the field of hip preservation surgery, arthroscopy, and endoscopy. European experts share their experiences on everything from basic injections to the most challenging hip procedures, offering step-by-step tutorials and highlighting important tips and tricks. Whereas most books on hip arthroscopy and hip preservation surgery concentrate on pathologies, surgical indications, and the basics of the treatment, here the focus is very much on the individual techniques and recognized variants. These techniques are clearly and precisely described with the aid of a wealth of photo and video illustrations. The coverage encompasses procedures applicable in the widest range of scenarios, including synovial pathologies, labral, chondral, and bony injuries, hip impingement, dysplasia and instability, snapping hips, gluteus medius and minimus tendonitis and tears, other tendinopathies, post-arthroplasty complications, and rehabilitation. The book is published in cooperation with ESSKA and will be an essential aid for orthopaedic surgeons at all levels of experience.
Contents:
Joint lavage, synovectomy, biopsy and loose body removal
Painful hip Arthroplasty assessment, Removal of cement or Loose Bodies
Femoral osteochondroplasty
Acetabular rim trimming
Open femoral osteochondroplasty and rim trimming
Subspine impingement decompression
Ischiofemoral impingement decompression
Osacetabuli removal or fixation
Core decompression
Fracture osteosynthesis
Periacetabular osteotomy
Reverse periacetabular osteotomy
Proximal Femoral osteotomy
Labral debridement-repair-reattachment
Labral reconstruction
Ligamentum teres reconstruction
Capsular plication and repair
Chondral debridement-abrasion-Microfracture
Open femoral head mosaic plasty
Trochanteric bursectomy and spur removal
Iliotibial band release and Gluteus maximus tendon release (Polesello)
Open Adductor Tenotomy
Psoas tenotomy
Hamstring repair/reinsertion
Open
Hamstring repair/reinsertion
Endoscopic
Sciatic nerve release / piriformis tenotomy.Digital Access Springer 2020 - DigitalYoung-Jo Kim, Eduardo N. Novais ; Sarah D. Bixby [and others], contributors.Digital Access Ovid 2021
- DigitalChangqing Zhang, editor.Summary: This book discusses disorders affecting the hip joint as well as its related structures, to help orthopedists develop an integrated way of thinking, and improve their decision-making strategies and treatment skills. The specific anatomy of the hip joint and the related structures provides vital motor functions. It also presents a challenge for orthopedists in terms of early diagnosis of disorders, which is essential for appropriate and effective treatment. The first part of the book provides a step-by-step introduction to intra-articular and abarticular hip disorders in both adults and children. It then describes the techniques and practicalities of managing various conditions in detail, presenting stereoscopic chromatic line drawings along with intraoperative illustrated figures. By demonstrating the regional anatomy, pathophysiology and related disorders in hip region, this book helps readers gain an understanding based on basic science and clinical research. It also offers instructive guidance to learners at different levels, including orthopedists, general practitioners and rehabilitation practitioners.
- Digitalvolume editors, K. Szabo, M.G. Hennerici.Contents:
Anatomy of the hippocampal formation / Schultz, C.; Engelhardt, M.
Structure and vascularization of the human hippocampus / Tatu, L.; Vuillier, F.
Coordinated network activity in the hippocampus / Draguhn, A.; Keller, M.; Reichinnek, S.
What animals can teach clinicians about the hippocampus / Lavenex, P.; Banta Lavenex, P.; Favre, G.
Memory function and the hippocampus / Opitz, B.
Neuropsychological measures of hippocampal function / Wicking, M.; Nees, F.; Steiger, F.
Conventional and diffusion-weighted MRI of the hippocampus / Szabo, K.; Forster, A.; Gass, A.
Functional MRI studies of the hippocampus / Nees, F.; Pohlack, S.T.
The hippocampus in neurodegenerative disease / Moodley, K.K.; Chan, D.
Stress, memory, and the hippocampus / Wingenfeld, K.; Wolf, O.T.
Epilepsy and the hippocampus / Chatzikonstantinou, A.
Transient global amnesia / Szabo, K.
Hippocampal stroke / Szabo, K.Digital Access Karger 2014 - Digitaledited by Prem Puri.Summary: The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been thoroughly revised and updated to reflect major advances that have occurred both in the understanding as well as the treatment of Hirschsprung's disease. Contents discuss the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and approaches to diagnosis such as radiology and manometry as well as Hirschsprung's disease in adolescents and adults. Surgical approaches are thoroughly covered and include a new chapter on intestinal transplantation options. The follow-up care and long-term outcomes of patients who have undergone therapy are also addressed in this edition. With several new chapters added and the contents updated and re-worked, this edition is authored by the leading current experts in their respective fields. It is a must-have book for pediatric surgeons, pediatricians, gastroenterologists, and colorectal surgeons.
Contents:
Hirschsprung's Disease: A Historical Perspective
Development of the Enteric Nervous system
Functional Anatomy of the Enteric System
Normal Colonic Morphology and Motor Function
Animal Models of Hirschsprung's Disease
Familial Hirschsprung's Disease
Genetics of Hirschsprung's Disease
Stem cell Therapy for Enteric neuropathies
Pathophysiology of Hirschsprung's Disease
Epidemiology and Clinical Characteristics of Hirschsprung's Disease
Associated Anomalies and Syndromes in Hirschsprung's Disease
Association between Hirschsprung's Disease and Multiple Endocrine Neoplasia Type 2a
Hirschsprung's Associated Enterocolitis
Radiological Diagnosis of Hirschsprung's Disease
Manometeric Diagnosis of Hirschsprung's Disease
Rectal Biopsy for the diagnosis of Hirschsprung's Disease
Histopathological Diagnosis of Hirschsprung's Disease
Total Colonic Aganglionosis
Hirschsprung's Disease in adolescents and adults
Variants of Hirschsprung's Disease
Megacystis-Microcolon-Intestinal Hypoperistalsis syndrome
Degenerative Hollow Visceral Myopathy Mimicking Hirschsprung's Disease
Transanal Pull-Through operation for rectosigmoid Hirschsprung's Disease
Laparoscopically Assisted Pull-Through operation for Hirschsprung's Disease
Redo Surgery for Hirschsprung's Disease
Early and late Complications following Pull-Through operation for Hirschsprung's Disease.-Morphological Basis of Persistent bowel problems following a properly performed pull-through operation for Hirschsprung's Disease
Bowel Management for the treatment of Chronic constipation and soiling in patients operated for Hirschsprung's Disease
Inflammatory Bowel Disease in patients with Hirschsprung's Disease
Intestinal Transplantation for Total Intestinal Aganglionosis
Urological and Sexual outcome in patients with Hirschsprung's Disease
Longterm Outcome and Quality of life after treatment of Hirschsprung's Disease. - DigitalTomoaki Taguchi, Hiroshi Matsufuji, Satoshi Ieiri, editors.Summary: This book provides essential information on the status quo and changing profile of Hirschsprung's disease and allied disorders. Hirschsprung's disease is a common cause of neonatal intestinal obstruction and one of the most important and most fascinating diseases in pediatric surgery throughout the world. Currently, the diagnosis and treatment of Hirschsprung's disease and allied disorders are in a state of constant development. Written by expert pediatric surgeons, Hirschsprung's Disease and the Allied Disorders presents state-of-the-art information, such as new genetic evidence, and historical operative techniques that were less invasive and resulted in fewer follow-up operations. It offers a highly informative guide that will greatly benefit all readers engaged in pediatric medicine, pediatric surgeons, and the medical staff of NICUs around the globe.
- Digital/PrintJon Meacham ; afterword by John Lewis.Summary: "John Lewis, who at age twenty-five marched in Selma and was beaten on the Edmund Pettus Bridge, is a visionary and a man of faith. Using intimate interviews with Lewis and his family and deep research into the history of the civil rights movement, Meacham writes of how the activist and leader was inspired by the Bible, his mother's unbreakable spirit, his sharecropper father's tireless ambition, and his teachers in nonviolence, Reverend James Lawson and Martin Luther King, Jr. A believer in hope above all else, Lewis learned from a young age that nonviolence was not only a tactic but a philosophy, a biblical imperative, and a transforming reality. At the age of four, Lewis, ambitious to become a preacher, practiced by preaching to the chickens he took care of. When his mother cooked one of the chickens, the boy refused to eat it--his first act of non-violent protest. Integral to Lewis's commitment to bettering the nation was his faith in humanity and in God, and an unshakable belief in the power of hope. Meacham calls Lewis "as important to the founding of a modern and multiethnic twentieth- and twenty-first century America as Thomas Jefferson and James Madison and Samuel Adams were to the initial creation of the nation-state in the eighteenth century. He did what he did--risking limb and life to bear witness for the powerless in the face of the powerful--not in spite of America, but because of America, and not in spite of religion, but because of religion"-- Provided by publisher.
Contents:
Overture: the last march
A hard life, a serious life: Troy, Alabama: beginnings to 1957
The spirit of history: Nashville, Tennessee: 1957-60
Soul force: the freedom rides: 1961
In the image of God and democracy: Birmingham and Washington: 1963
We are going to make you wish you was dead: Freedom Summer and Atlantic City: 1963-64
I'm going to die here: Selma, Alabama: 1965
This country don't run on love: New York, Memphis, Los Angeles: 1966-68
Epilogue: against the rulers of the darkness.Digital Access 2020Limited to 1 simultaneous userSUNet ID login required - DigitalReinhart Jarisch, editor.Summary: Histamine is an important mediator of allergic diseases such as hay fever and bronchial asthma, food allergies, urticaria, and drug hypersensitivity. Knowledge of histamine as a cause of numerous non-allergic symptoms and signs is, however, limited. In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, atopic dermatitis, and osteoporosis. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages, and intolerance to red wine. Diagnosis of histamine intolerance is explained, and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the conditions mentioned above and also consider the relation of histamine to vitamin B6 and the specific immunotherapy of allergies. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance, and by assisting in the selection of therapeutic measures.
Contents:
Introduction
Histamine and biogenic amines
Symptoms of histamine intolerance
Allergy and intolerance to drugs
Surgery and dental operations
Histamine intolerance in females
Atopic dermatitis
Specific immunotherapy of allergies
Histamine and vitamin B6
Histamine and seasickness
Histamine and osteoporosis.Digital Access Springer 2015 - DigitalGuido Massi, Philip E. LeBoit.Summary: The histopathologic interpretation of melanocytic neoplasms is probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions that histopathologists might encounter. Each case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist both general pathologists and dermatopathologists in making an accurate diagnosis applicable to their daily practice, and one that can be understood by clinicians. They achieve this by providing criteria that can serve as a sound basis for an unequivocal diagnosis in most cases. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
Contents:
Criteria for the Diagnosis of Benign Melanocytic Nevus
Melanocytic Hyperplasia
Melanotic Macules
Commonon Nevus
Congenital Nevus
Junctional Anomalies in Congenital and Acquired Nevi in the First Year of Life
Proliferative Nodules in Congenital Nevi
Nevus Spilus
Dermal Melanocytoses
Common Blue Nevus
Cellular Blue Nevus
SPITZ Nevus
Reed Nevus
Deep Penetrating Nevus
Dysplastic & Clarkss Nevus
Combinedin Nevus
Nevi on Acral Skin
Nevi on Genital Skin
Nevi in the Oral Cavity
Polypoid Nevus of Pregnancy and Milk Line Nevi
Nevi OF the Conjunctiva
Melanocytic Nevi Affected by inflammatory Skin Dideases
Halo Nevus
Recurrent and Persistent Nevus
Traumatised Nevi
Benign Melanocytoma
Medicolegal Cases
Criteria for the Diagnosis OF Malignant Melanoma
Melanoma in situ
Lentigo Maligna
Superficial Spreading Pattern of Melanoma
Nodular Pattern of Melanoma
Melanoma with Spindle Cell
Nevoid Melanoma
Spitzoid Melanoma
Desmoplastic Melanoma
Neurotropic Melanoma
Melanoma with Neural Differentiaton
Myxoid Melanoma
Melanoma with Features of Blue Nevus
Animal Type Melanoma
Melanoma on Blue Nevus
Unusual and Bizarre forms of Melanoma
Melanoma on Nevus
Melanoma on Palms, Soles and Subungual Bed
Melanoma on Genital Skin
Melanoma on Oral Cavity
Melanoma on Conjunctiva
Recurrent and Persistent Melanoma
Regressing and Regressed Melanoma
Cutaneous Metastatic Melanoma
Malignant Melanocytoma
Medicolegal Cases
Molecular Biology in the Diagnosis of Nevi and Melanoma
Histological Prognostic Factors.Digital Access Springer 2014 - DigitalWojciech Pawlina.Summary: "Combining a reader-friendly textbook and a rich, full-color atlas, Histology: A Text and Atlas: With Correlated Cell and Molecular Biology, 9th Edition, equips medical, dental, health professions, and undergraduate biology and cell biology students with a comprehensive grasp of the clinical and functional correlates of histology and a vivid understanding of the structural and functional details of cells, tissues, and organs."--Provided by publisher.
Contents:
Methods
Cell cytoplasm
Cell nucleus
Tissues: concept and classification
Epithelial tissue
Connective tissue
Cartilage
Bone
Adipose tissue
Blood
Muscle tissue
Nerve tissue
Cardiovascular system
Immune system and lymphatic tissues and organs
Integumentary system
Digestive system I: Oral cavity and associated structures
Digestive system II: Esophagus and gastrointestinal tract
Digestive system III: Liver, gall bladder, and pancreas
Respiratory system
Urinary system
Endocrine system
Male reproductive system
Female reproductive system
Eye
Ear.Digital Access LWW Health Library [2024] - DigitalMichael H. Ross, PhD (deceased), Professor and Chair Emeritus, Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida, Wojciech Pawlina, MD, FAA, Professor of Anatomy and Medical Education, Fellow of the American Association of Anatomists, Chair, Department of Anatomy, Department of Obstetrics and Gynecology, Director of Procedural Skills Laboratory, Mayo college of Medicine, Rochester, Minnesota.Summary: Now in its seventh edition, Histology: A Text and Atlas is ideal for medical, dental, health professions, and undergraduate biology and cell biology students. This best-selling combination text and atlas includes a detailed textbook, which emphasizes clinical and functional correlates of histology fully supplemented by vividly informative illustrations.
Contents:
Methods
Cell cytoplasm
The cell nucleus
Tissues : concept and classification
Epithelial tissue
Connective tissue
Cartilage
Bone
Adipose tissue
Blood
Muscle tissue
Nerve tissue
Cardiovascular system
Lymphatic system
Integumentary system
Digestive system I : oral cavity and associated structures
Digestive system II : esophagus and gastrointestinal tract
Digestive system III : liver, gallbladder, and pancreas
Respiratory system
Urinary system
Endocrine organs
Male reproductive system
Female reproductive system
Eye
Ear.Digital Access LWW Health Library (Medical Education) 2016 - DigitalWojciech Pawlina, Michael H. Ross.Summary: "Histology: A Text and Atlas is ideal for medical, dental, health professions, and undergraduate biology and cell biology students. This best-selling combination text and atlas includes a detailed textbook, which emphasizes clinical and functional correlates of histology fully supplemented by vividly informative illustrations and photomicrographs. Separate, superbly illustrated atlas sections follow almost every chapter and feature large-size, full-color digital photomicrographs with labels and accompanied descriptions that highlight structural and functional details of cells, tissues, and organs"--Provided by publisher.
Contents:
Methods
Cell cytoplasm
The cell nucleus
Tissues : concept and classification
Epithelial tissue
Connective tissue
Cartilage
Bone
Adipose tissue
Blood
Muscle tissue
Nerve tissue
Cardiovascular system
Immune system and lymphatic tissues and organs
Integumentary system
Digestive system I : oral cavity and associated structures
Digestive system II : esophagus and gastrointestinal tract
Digestive system III : liver, gallbladder, and pancreas
Respiratory system
Urinary system
Endocrine organs
Male reproductive system
Female reproductive system
Eye
Ear.Digital Access LWW Health Library (Medical Education) 2020 - DigitalAbraham L. Kierszenbaum, Laura L. Tres.Contents:
Epithelium
Epithelial glands
Cell signaling
Connective tissue
Osteogenesis
Blood and hematopoiesis
Muscle tissue
Nervous tissue
Sensory organs vision and hearing
Immune-lymphatic system
Integumentary system
Cardiovascular system
Respiratory system
Urinary system
Upper digestive system
Lower digestive system
Digestive glands
Neuroendocrine system
Endocrine system
Spermatogenesis
Sperm transport and maturation
Follicle development and the menstrual cycle
Fertilization, placentation, and lactation.Digital Access ClinicalKey 2016 - Digital[edited by] Stacey E. Mills.Summary: "The fourth edition of Histology for Pathologists was published in 2012 and, as before, it is again reasonable to ask if "normal" has changed enough in the ensuing 6 years to justify a new edition. The answer, of course, is that normal has not changed at all (evolution is indeed a slow process!) but our perception of normal continues to expand and improve. In particular, we have developed many new immunohistochemical markers, and the ever-growing spectrum of their expression in normal tissues provides insights into pathologic processes arising from or differentiating toward these tissues. We also continue to recognize new variations of normal that cause diagnostic confusion and touch on the interface between normal and disease. Accordingly, the fifth edition brings incremental but valuable improvements in our perceptions of human histology"--Provided by publisher.Digital Access Ovid 2020
- DigitalShabir Ahmad Ganai.Summary: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors therapeutic efficacy against various neurological complications.
Contents:
Chapter 1. Role of Epigenetics in neurological diseases
Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens
Chapter 3. Distinct classes of HDACs
Chapter 4. HDAC implications in neurological diseases
Chapter 5. HDAC inhibitors and their structurally distinct groups
Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders
Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies
Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy
Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents
Chapter 10. Future directions of epigenetic research in tackling neurological complications.Digital Access Springer 2019 - DigitalDong Fang, Junhong Han, editors.Summary: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
Contents:
Chapter 1: Overview of histone modification
Chapter 2: The histone H3 family and its deposition pathways
Chapter 3: Histone H3K27M Mutation in Brain Tumors
Chapter 4: Histone Mutations and Bone Cancers
Chapter 5: Histone H3G34 mutation in brain and bone tumors
Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas
Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target. - DigitalHenrik Hellquist, Alena Skalova.Summary: Over the past 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes the most diagnostic challenges and problems for general pathologists. Among the reasons for this are the relative rarity of salivary gland tumors (as a result of which the general pathologist does not gain sufficient personal experience in their diagnosis), their striking diversity (there are almost 40 different histological tumor entities), and the fact that some tumours dedifferentiate and some benign tumors progress to become malignant. This book is a comprehensive guide to salivary gland pathology that illustrates almost every type of salivary gland tumor and will assist greatly in routine diagnostic work. Non-neoplastic lesions, benign epithelial tumors, malignant epithelial tumors, and non-epithelial and secondary tumors are all covered in detail, and the WHO and TNM classifications are clearly explained. Another significant feature is the incorporation of important knowledge gained during the past few years regarding the genetics of salivary gland tumors. Histopathology of the Salivary Glands will be of interest not only to pathologists but also to dentists, ENT and head and neck surgeons, and oncologists.
Contents:
Histology
Non-neoplastic Lesions
Pleomorphic Adenoma
Myoepithelioma
Warthin Tumour
Other Adenomas
Mucoepidermoid Carcinoma
Adenoid Cystic Carcinoma
Acinic Cell Carcinoma
Carcinoma Ex Pleomorphic Adenoma
Salivary Duct Carcinoma
Polymorphous Low-Grade Adenocarcinoma
Myoepithelial Carcinoma and Epithelial-Myoepithelial Carcinoma
Mammary Analogue Secretory Carcinoma (MASC)
Other Carcinomas
Miscellaneous. - Digitaledited by David P. Boyle, Derek C. Allen.Summary: This book is an easily comprehensible and practicable framework for standardised histopathology reports in surgical cancer. The pathological features of the common carcinomas are detailed and non-carcinomatous malignancies are also summarised. 8th edition TNM and WHO classifications of cancers are incorporated, with comments on any associated pathology, diagnostic clues and prognostic criteria supplemented visually by line diagrams. Each chapter's introduction gives epidemiological, clinical, investigative and treatment summary details. Other pathology includes updated immunophenotypic expression and molecular techniques. The impact of these ancillary investigations on diagnosis, and as biomarkers of prognosis and prediction of response to treatment is summarised, as is the effect of adjuvant treatments on cancers. Experience based clues are given throughout as aids to tumour typing, grading, staging, and gauging prognosis and response to treatment. Histopathology Reporting: Guidelines for Surgical Cancer, Fourth Edition is invaluable for trainee and consultant diagnostic histopathologists all over the world, equipping the reader to produce high quality, clinically appropriate histopathology reports, and to participate in contemporary multidisciplinary team management of patients with surgical cancer.
Contents:
Introduction
Gastrointestinal Cancer: Oesophageal Carcinoma
Gastric Carcinoma
Ampulla of Vater and Head of Pancreas Carcinomas
Small Intestinal Carcinoma
Colorectal Carcinoma
Vermiform Appendix Tumours
Anal Canal Carcinoma (with Comments on Pelvic Exenteration)
Gall Bladder Carcinoma
Extrahepatic Bile Duct Carcinoma
Liver Carcinoma
Head and Neck Cancer: General comments
Lip and Oral Cavity Carcinomas
Oropharyngeal Carcinoma (with comments on Nasopharynx and Hypopharynx)
Nasal Cavity and Paranasal Sinus Carcinomas
Laryngeal Carcinoma
Salivary Gland Tumours
Thyroid Gland Tumours (with comments on Parathyroid)
Respiratory and Mediastinal Cancer: Lung Carcinoma
Malignant Mesothelioma
Mediastinal Cancer
Skin Cancer: Non-Melanocytic Skin Carcinoma
Malignant Melanoma
Breast Cancer: Breast Carcinoma
Gynaecological Cancer: Ovarian Carcinoma (with comments on Fallopian Tube Carcinoma)
Endometrial Carcinoma
Cervical Carcinoma
Vaginal Carcinoma
Vulval Carcinoma
Gestational Trophoblastic Tumours
Urological Cancer: Renal Cell and Renal Pelvis/Ureter Carcinomas
Bladder Carcinoma
Prostate Carcinoma
Urethral Carcinoma
Testicular Cancer
Penile Carcinoma
Lymph Node Cancer: Nodal Malignant Lymphoma (with comments on Extranodal Malignant Lymphoma and Metastatic Cancer)
Bone and Soft Tissue Cancer: Bone and Soft Tissue Sarcomas (with comments on Retroperitoneum and Adrenal Gland)
Ophthalmic Cancer: Intraocular Malignancy
Extraocular Malignancy
Endocrine Cancer: Thyroid Gland Tumours
Adrenal Gland Tumours. - DigitalDerek C. Allen, R. Iain Cameron, editors.Summary: This book integrates tumour anatomy; clinical presentation and investigations; surgical considerations; pathology and clinically appropriate dissection and reporting of surgical specimens. The 2nd edition is up-to-date with TNM 7 & RPath cancer datasets.Digital Access Springer 2017
- Digital/PrintThomas J. Inzana, editor.Contents:
Taxonomy of Histophilus somni
Histophilosis as a Natural Disease
Histophilus somni Genomics and Genetics
Interactions on Histophilus somni with Host Cells
Histophilus somni Surface Proteins
Host Immune Response to Histophilus somni
The Many Facets of Lipooligosaccharide as a Virulence Factor of Histophilus somni
Exopolysaccharide Production and Biofilm Formation by Histophilus somni. - Digital/PrintRafael Schiaffino.Digital Access
- DigitalThomas S. Helling, Daniel Azoulay.Summary: For the surgeon of antiquity the liver has been an organ of mystery - and danger. Attempts to repair its wounds or remove tumors were fraught with hemorrhage and often a fatal outcome. Most forays were those to remove easily accessible tumors on the liver edge, but bleeding was a feared consequence still and surgeons wielded a plucky fortitude to take on even those. Not until the mid-20th Century were surgeons able to safely excise neoplasms that lay deep within the liver substance. Jean-Louis Lortat-Jacob achieved notoriety in his famous Paris hepatectomy of 1951 but he was not the first. That distinction may have belonged to German Professor Walther Wendel in 1910 or to Japanese surgeon Ichio Honjo who reported his operation in 1950, but in Japanese. It was not picked up by the Western surgical community until 1955. Names such as Hugo Rex, James Cantlie, Jean-Louis Lortat-Jacob, Tôn Thá̂t Tùng, Jacques Hepp, Claude Couinaud, Henri Bismuth, Thomas Starzl, Roy Calne, and a host of others highlight the extraordinary curiosity, tenacity, and skill of those surgeons who broached unknown territory to master understanding and techniques of manipulation, resection, and transplantation that were formerly considered unapproachable by the surgical world.
Contents:
Preface
Introduction
The Bold Adventure of Lortat-Jacob
The Liver: Impossible Salvations
The Art of Operating
Fin de Siècle: Marvels of the Age
The World Wars and Hemorrhage Control
A World-Wide Phenomenon: Liver Surgery in the Far East
Beginning the Modern Era
The Anatomists
The French School
Bach, Beethoven, and Brahms
The Era of Transplantation
Splitting the Soul
On Regeneration
Prometheus Renewed. - DigitalMakini Chisolm-Straker, Katherine Chon, editors ; forewords by Joshua M. Sharfstein and Ruth J. Simmons.Summary: A public health approach to human trafficking requires a nuanced understanding of its root causes. This textbook applies a historical lens to human trafficking from expert resources for the multidisciplinary public health learner and worker. The book challenges the anti-trafficking paradigm to meaningfully understand historical legacies of present-day root-causes of human trafficking. This textbook focuses on history's utility in public health. It describes history to contextualize and explain present times, and provides public health lessons in trafficking prevention and intervention. Public health recognizes the importance of multiple systems to solve big problems, so the chapters illustrate how current anti-trafficking efforts in markets and public systems connect with historical policies and data in the United States. Topics explored include: Capitalism, Colonialism, and Imperialism: Roots for Present-Day Trafficking Invisibility, Forced Labor, and Domestic Work Addressing Modern Slavery in Global Supply Chains: The Role of Businesses Immigration, Precarity, and Human Trafficking: Histories and Legacies of Asian American Racial Exclusion in the United States Systemic and Structural Roots of Child Sex Trafficking: The Role of Gender, Race, and Sexual Orientation in Disproportionate Victimization The Complexities of Complex Trauma: An Historical and Contemporary Review of Healing in the Aftermath of Commercialized Violence Historical Context Matters: Health Research, Health Care, and Bodies of Color in the United States Understanding linkages between contemporary manifestations of human trafficking with their respective historical roots offers meaningful insights into the roles of public policies, institutions, cultural beliefs, and socioeconomic norms in commercialized violence. The textbook identifies sustainable solutions to prevent human trafficking and improve the health of the Nation. The Historical Roots of Human Trafficking is essential reading for students of public health, health sciences, criminology, and social sciences; public health professionals; academics; anti-trafficking advocates, policy-makers, taskforces, funders, and organizations; legislators; and governmental agencies and administrators.
- PrintRobert S. Sherins.Summary: "Origin of modern ocular prosthetics : a retrospective review of the evolution and ancient spiritual perceptions about the eye -- Eight generations of ocularists, Lauscha, Germany -- Augenkunst, ocular pathology kits -- Ancient spiritual perceptions: Aurveda - Hindus, Pre-dynastic Egyptians/Nubians, Pharoahs, early Hebrew & Christian traditions -- Development of modern ocular prosthetics -- A research manuscript, by Robert S. sherins, M.D."--page 2.
Contents:
Title page
About the author
Acknowledgment
Table of contents
Preface
Ocular prosthetic Augenkunst
About Danz and Sons, Inc.
American Society of Ocularists / National Boards
Ancient and contemporary history of artificial eyes, board certified ocularist by William Danz Sr.
Foreward by Phillip A. Danz
Chapter one : Ludwig Muler-Uri, ocularist
Chapter two : Lauscha, Germany
Chapter three : Muler-Danz genealogical family tree
Chapter four : surgical enucleation
Chapter five : ancient Egyptian funerary practices, ancient Egyptian temple reliefs & images
Chapter six : ancient Auirvedic and Hindu practices, third eye chakra, historic Ayrveda culture, neurologic considerations of the pineal body, ancient glass paste eyes, Keyn Eyin Hore
Chapter seven : ocular pathology kit
Chapter eight : modern acrylic prosthetic process by Phillip A. Danz
Chapter nine : glass eye fabrication by William A. Danz
Bibliography. - Digitaledited by Madeleine Mant, Chris Mounsey.Summary: "The History and Bioethics of Medical Education: "You've Got to Be Carefully Taught" continues the Routledge Advances in the History of Bioethics series by exploring approaches to the teaching of bioethics from disparate disciplines, geographies, and contexts. Van Rensselaer Potter coined the phrase "Global Bioethics" to define human relationships with their contexts. This and subsequent volumes return to Potter's founding vision from historical perspectives and asks, how did we get here from then? The patient-practitioner relationship has come to the fore in bioethics; this volume asks: is there an ideal bioethical curriculum? Are the students being carefully taught and, in turn, are they carefully learning? This volume will appeal to those working in both clinical medicine and the medical humanities, as vibrant connections are drawn between various ways of knowing"-- Provided by publisher.Digital Access TandFonline 2021
- DigitalUgo Filippo Tesler.Summary: The beginning of cardiac surgery is generally considered to be the successful repair of a wound of the heart that took place on the 7th of September 1896 in Frankfurt am Main. This operation put an end to the widespread belief that nature had set the heart beyond the limits of surgery. The successive development of heart surgery moved together with other advances that were rapidly taking place in various fields of medicine and surgery and which, already in the first half of the 20th century, had allowed surgical pioneers to successfully correct a number of congenital and acquired heart disease.Digital Access ProQuest Ebook Central 2020
- Printedited by Christopher T. Leffler.Summary: "The History of Glaucoma, the latest in the Hirschberg series of the history of ophthalmology, covers the twists, turns, and paradigm-shifts in the glaucoma concept over the past two millennia. Previously, scholars were not able to agree on how the term glaucoma, which related in antiquity to the color of a diseased eye, ended up describing an excavated optic neuropathy which has nothing to do with color. The volume begins in the ancient world, and proceeds all the way to the modern era of optical coherence tomography, minimally invasive surgery, and anti-VEGF agents. Ophthalmic historians and glaucoma specialists from the United States, Europe, Asia, and Latin America have contributed their scholarship and recollections to this volume, which includes photographs from private collections, information from unpublished documents, and new translations from Latin, Arabic, French, German, and Spanish. The work of masters such as Julius Hirschberg and Max Meyerhof is supplemented by the latest scholarship, which has benefited from the explosion in digitally-accessible historical documents. This new scholarship has upended many deeply rooted beliefs about ophthalmology history. Most important, the volume relates the personal stories of eye surgeons and patients, to bring the past to life. The History of Glaucoma is a must-have for anyone interested in medical history"--Publisher information.
Contents:
Foreword / Robert N. Weinreb
An Introduction to the History of Glaucoma / Christopher T. Leffler
1. Glaucoma in the Ancient Greek and Roman Worlds / Christopher T. Leffler, Stephen G. Schwartz
2. Glaucoma in the Medieval Arabic World / Christopher T. Leffler, Wasim A. Samara, Tamer M. Hadi, Ali Salman, Faraaz A. Khan
3. Glaucoma in the European Middle Ages and Renaissance / Christopher Leffler, Eric Peterson
4. Buphthalmos / Harry Mark
5. The Early History of Glaucoma in East Asia / Christopher Leffler, Ka-Wai Fan
6. Hydrophthalmia and Paracentesis / Christopher Leffler, Stephen G. Schwartz
7. Glaucoma during the Enlightenment and Early Modern Periods (1700-1849) / Christopher Leffler, Stephen Schwartz
8. John Thomas Woolhouse (1664-1733/4) and his Family of Oculists (1600-1751) / Christopher T. Leffler, Stephen G. Schwartz
9. "Chevalier" John Taylor and His Descendants / Stephen G. Schwartz, Christopher T. Leffler
10. Georg Joseph Beer and Glaucoma / Harry Mark
11. Helmholtz and the Development of the Ophthalmoscope / Richard Keeler
12. Glaucoma : A Pressure-Induced Optic Neuropathy (1850-1870) / Christopher Leffler
13. Aqueous humor dynamics / Harry Mark
14. Angle Closure Glaucoma Since 1871 / Christopher Leffler, Surbhi Bansal
15. The History of Malignant Glaucoma / Andrzej Grzybowski, Piotr Kanclerz
16. The History of Tonometry / Steven Newman
17. A History of Perimetry and Visual Field Testing / Chris Johnson
18. Open Angle Glaucoma in the Twentieth Century / Christopher Leffler
19. The History of Glaucoma Medications / Tony Realini, Eva DeVience
20. The History of the Surgical Microscope in Ophthalmology / Richard Keeler
21. The History of Glaucoma Surgery and Laser Treatment / Reza Razeghinejad, Joanna Liput, George Spaeth
22. Sympathectomy for glaucoma: its rise and fall (1898-1910) / Robert M. Feibel
23. The Pathogenesis of Glaucomatous Optic Neuropathy / Sohan Singh Hayreh
24. Mechanisms of Glaucoma Without Elevated Intraocular Pressure / Russell Swan, Brandon Baartman, Michael Greenwood, John Berdahl
25. The History of Pediatric Glaucoma / Jana Bregman, Mona A. Kaleem, Janet Alexander, Sara Fard, Natario L. Couser
26. The History of Glaucoma in Mexico / Rolando Neri-Vela
27. The History of Neovascular Glaucoma / Adam Pflugrath
28. The History of Iridocorneal Endothelial Syndrome / Surbhi Bansal
29. The History of Pseudoexfoliation / Andrzej Grzybowski, Piotr Kanclerz
30. The History of Pigment Dispersion Syndrome and Pigmentary Glaucoma / Lynn E. Harman, Curtis E. Margo
31. Uveitic Glaucoma / Christopher Donovan, Lynn E. Harman
32. Immunological Mechanisms in Glaucoma : History of Ideas and Hypotheses / Lynn E. Harman, Curtis E. Margo
33. The Evolution of the Optic Disc Analysis : Past and Present / Fritz Dannheim
34. The History of Optical Coherence Tomography / Rachel L. Anderson, Joel S. Schuman
35. Glaucoma and other Ophthalmic Disorders in Selected Artists / James Ravin. - DigitalShaun R. McCann.Contents:
1. Science before science
2. The Enlightenment and the unravelling of the circulation
3. From a dream to a nightmare: HIV, haemophilia, and AIDS
4. Red cells: how they live and how they die
5. Blood and the hidden virus
6. Radiation and transplantation: towards an understanding od stem cells
7. Leukaemia
8. 'If you prick us do we not bleed?': bleeding and blood clotting
9. Molecules, genes, and gene therapy
10. The same specialty: different approaches!
11. The role of technology in haematology
12. Combination chemotherapy.Digital Access Oxford 2016 - Printby G.P. Srivastava ; with a foreword from George Urdang.
- Printwritten and illustrated by Susan Dufresne.
- DigitalElie M. Ferneini, Michael T. Goupil, Steven Halepas, editors.Summary: The multi-authored, multi-institutional, and multi-specialty-based text is designed as a valuable resource for surgeons working on the maxillofacial region. Meant to be a clinically based history of the past, the present, and the future of the field, this is a one-of-a-kind text that will cater to a variety of professions: from oral & maxillofacial surgeons, plastic and reconstructive surgeons, otolaryngologists head and neck surgeons, cosmetic surgeons and the general dental practitioner. The History of Maxillofacial Surgery: An Evidence-Based Journey is divided into three sections for ease of understanding: The first section gives an overview of the early history; the second section provides a discussion of conventional procedures; and the third section gives a history of advanced procedures and techniques. By understanding the fundamental procedures and techniques of the field, practitioners can continue to further the field by building upon the past. Including historic case studies paired with real patient photos, this text details why professionals do what they do today with insight directly from the clinic. To provide a unique perspective the book is edited by three individuals at different stages of their careers. Each chapter is authored by a young surgeon paired with a seasoned surgeon.
Contents:
Intro
Foreword
Preface
Contents
Contributors
Part I: Early History
Saint Apollonia: Patron Saint of Dentistry
1 Introduction
2 Egypt 249 CE, the First Written Description of Saint Apollonia
3 The Legend
4 The Patroness of Dentistry and the Healer of Dental Pain
5 Relics
6 St. Apollonia Commemorations: Statues, Churches, Plazas, Paintings, Stained Glass Windows
References
Anatomists: The Basis of Surgery
1 Introduction
2 From Galen to Vesalius
3 The Sphenoid Bone
4 Modern Anatomical Imaging 5 A Brief History of Cadaver Acquisition for Education
6 Anatomy Through Art and Atlases
7 Summary
References
The Barber-Surgeons
1 Introduction
2 Origins
3 Scope of Practice
4 European Medical Education
5 Notable Barber-Surgeons
6 The London Barber-Surgeons' Guild
7 Barber Pole
8 End of an Era
9 Summary
References
The Three Pillars of Surgery
1 Introduction
2 Hemostasis - Ambroise Paré
3 Anesthesia - Horace Wells
4 Asepsis - Joseph Lister
5 Summary
References
Anesthesia
1 Introduction
2 Inhalation Anesthetic Agents 3 Intubation and Inhaled Anesthesia Technology
4 Parenteral Anesthesia
4.1 Opioids
5 Sedative Hypnotics and Other Intravenous Anesthetics
6 Neuromuscular Blockers
7 Parenteral and Local Anesthesia Technology
8 Local Anesthesia
8.1 Local Anesthesia Drugs
9 Summary
References
The Legacy of Maxillofacial Surgery During the Great War
1 Introduction
2 Front-Line Care: Origins of the Harvard Unit
3 Tertiary Care-Sir Harold Delf Gillies and the Surgeons of Sidcup
4 Maxillofacial Surgical Advances by the Central Powers 5 Anna Ladd and Jane Poupelet and Their Facial Masks
6 Summary
References
Formation of Head and Neck Surgical Specialties
1 Introduction
2 Otolaryngology and Head and Neck Surgery
2.1 Birth of the Specialty
2.2 Organizations
3 Ophthalmology
3.1 Birth of the Specialty
3.2 Organizations
4 Oral and Maxillofacial Surgery
4.1 Birth of the Specialty
4.2 Organizations
5 Plastic and Reconstructive Surgery
5.1 Birth of the Specialty
5.2 Organizations
6 Summary
References
Part II: Conventional Procedures
Head and Neck Infections
1 Prehistory 2 Treatment of Infection in Antiquity
References
Evolution of Tooth Removal
1 Introduction
2 Ancient History
2.1 Prehistory Humans
2.2 Eastern and Egyptian Era
2.3 Greek and Roman Era
2.4 Practitioners
3 Early Instruments
4 Nineteenth-Century Pioneers
5 Twentieth-Century Notables
6 Summary
References
Dental Implants and Bone Augmentation
1 Introduction
2 Implants in the Early Twentieth Century
3 Brånemark and the Foundations of Modern Implantology
4 Bone Augmentation
5 Guided Bone Regeneration
6 Sinus Lifts
7 The Twenty-First Century - DigitalMorris F. Collen, Marion J. Ball, editors.Summary: This is a meticulously detailed chronological record of significant events in the history of medical informatics and their impact on direct patient care and clinical research, offering a representative sampling of published contributions to the field. The History of Medical Informatics in the United States has been restructured within this new edition, reflecting the transformation medical informatics has undergone in the years since 1990. The systems that were once exclusively institutionally driven - hospital, multihospital, and outpatient information systems - are today joined by systems that are driven by clinical subspecialties, nursing, pathology, clinical laboratory, pharmacy, imaging, and more. At the core is the person - not the clinician, not the institution - whose health all these systems are designed to serve. A group of world-renowned authors have joined forces with Dr Marion Ball to bring Dr Collen's incredible work to press. These recognized leaders in medical informatics, many of whom are recipients of the Morris F. Collen Award in Medical Informatics and were friends of or mentored by Dr Collen, carefully reviewed, editing and updating his draft chapters. This has resulted in the most thorough history of the subject imaginable, and also provides readers with a roadmap for the subject well into later in the century.
- DigitalMichael R. Kronenfeld, Jennie Jacobs Kronenfeld.Summary: "This book covers the history of medical libraries and librarianship from the founding of the Medical Library Association in 1898 to today. The authors present the different stages in the evolution of health science librarianship and conclude with a discussion of the new, digital era of health science libraries"-- Provided by publisher
Contents:
John Shaw Billings and the Library of the Office of the Army Surgeon General: 1836-1898
The gentleman physician librarian era: 1898-1945
The era of the development of the clinical research infrastructure (NIH), the rapid expansion in funded and published clinical research, and the emergence of the National Library of Medicine: 1945-1962
The era of the development of the National Library of Medicine, online digital subject searching (MEDLINE) and the creation of the health science library infrastructure: 1962-1975
The MEDLINE Era: The golden age of medical libraries: 1978-1995
The era of universal access to information and the transition from paper to digitally based medical libraries: 1995-2015
The emerging era of the digital health sciences library: 2015.Digital Access ProQuest Ebook Central 2021 - PrintPlinio Prioreschi.Contents:
v. 1. Primitive and ancient medicine
v. 2. Greek medicine
v. 3. Roman medicine
v. 4. Byzantine and Islamic medicine
v. 5. Medieval medicine. - PrintPlinio Prioreschi.Contents:
v. 1. Primitive and ancient medicine
v. 2. Greek medicine - PrintGill Paul.Summary: Takes readers on a 12,000-year journey to explore significant items that have advanced medical knowledge and practice. The fifty objects range from the everyday (a bottle of Aspirin) to singular medical advances (heart transplant pioneer Christian Bernard on the cover of TIME magazine). The objects are presented chronologically and described in two to four pages with illustrations, 150 beautiful archive images in all. Fact boxes note Location, Date, and Field, for example, epidemiology. Engaging text describes the artifacts in their social and cultural context, as well as their role in disease treatment and prevention.
Contents:
Neolithic Trepanned Skulls
The Edwin Smith Papyrus
Clay Tablets from Mesopotamia
Atharva Veda
Huangchi Neijing
The Tree of Hippocrates
The Aqua Appia
Dioscorides' Materia Medica
Galen's Phlebotome
The Hôtel-Dieu
Ten Treatises on the Eye
The School of Salerno
Avicenna's Tomb
Plague Doctor's Mask
De Humani Corporis Fabrica
Santorio Santorio's Thermoscope
Harvey's Diagram of Blood Circulation
Chamberlen's Forceps
Van Leeuwenhoek's Microscope
The Cinchona Tree
Edward Jenner's Lancet
Laënnec's Stethoscope
Morton's Ether Inhaler
TB Sanatorium in Görbersdorf
John Snow's Cholera Map
Florence Nightingale's Lamp
Louis Pasteur's Flask
The Snellen Eye Chart
The Red Cross Symbol
Joseph Lister's Donkey Engine
The X-ray Machine
Bayer Aspirin
Sigmund Freud's Couch
Harold Gillies' Tubed Pedicle
Spanish Flu Mask
Lilly's Insulin Syringe
The Iron Lung
Alexander Fleming's Petri Dish
Bryukhonenko's Autojektor
Willem Kolff's Artificial Kidney
World Health Organization Flag
Crick and Watson's Double Helix
Cigarette Package Health Warning
The First Heart Transplant
MRI Scanner
Surgical Robots
AIDS Awareness Ribbon
Stem Cells
Thought-Controlled Prosthesis
Protective Clothing for Ebola. - DigitalZoltan A. Nagy.Summary: A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author.Digital Access ScienceDirect 2014
- Digitalvolume editors, J. Bogousslavsky, F. Boller, M. Iwata.Contents:
The discovery of cerebral specialization / Harris, L.J
The introduction of emotions and behavior in the assessment of neurological patients / Genetti Gatfield, M., Colombo, F., Annoni, J.-M
Anatomical error of Pierre Marie's 'zone lenticulaire' / Iwata, M
Gogi (word meaning) aphasia and its relation with semantic dementia / Yamadori, A
Alexia and agraphia from 1861 to 1965 / Henderson, V.W
Kanji (morphogram) and kana (phonogram) problem in Japanese alexia and agraphia / Sakurai, Y
Early history of amnesia / Langer, K.G
History of anosognosia / Gainotti, G
History of amusia / Kawamura, M., Miller, M.W
Hemineglect and attentional dysfunction / Langer, K.G., Piechowski-Jozwiak, B., Bogousslavsky, J
History of frontal syndromes and executive dysfunction / DeRight, J
History of subcortical cognitive impairment / Filley, C.M
History of dementia / Assal, F
Neurology versus psychiatry? Hallucinations, delusions, and confabulations / Carota, A., Bogousslavsky, J
Developmental cognitive deficits : a historical overview of early cases / Eling, P
History of neuropsychological assessment / Eling, P
Historical pathway from description of cognitive recovery to formal neuropsychological rehabilitation / Magnin, E., Ryff, I., Brun, B., Decavle, P., Hague, S., Moulin, T
Shining a light on some of the most famous 19th and 20th century's neuropsychologists / Walusinski, O., Boller, F., Henderson, V.W.Digital Access Karger 2019 - Printby Adam Politzer ; an English translation by Stanley Milstein, Collice Portnoff, Antje Coleman.Contents:
v. 1. From earliest times to the middle of the nineteenth century.Print Access - PrintMudry, Albert.
- PrintDavid Anversa.
- Digital/Printby Johan P. Mackenbach.Summary: "In A History of Population Health Johan P. Mackenbach offers a broad-sweeping study of the spectacular changes in people's health in Europe since the early 18th century. Most of the 40 specific diseases covered in this book show a fascinating pattern of 'rise-and-fall', with large differences in timing between countries. Using a unique collection of historical data and bringing together insights from demography, economics, sociology, political science, medicine, epidemiology and general history, it shows that these changes and variations did not occur spontaneously, but were mostly man-made. Throughout European history, changes in health and longevity were therefore closely related to economic, social, and political conditions, with public health and medical care both making important contributions to population health improvement"-- Provided by publisher.
Contents:
Utopia come true?
The epidemiologic transition theory
How to read this book
Part 1. Long-term trends: A bird's eye view
Long-term trends in population health
Changes in over-all population health
Changes in disease patterns
Epidemiologic transition
Understanding trends in population health
Theories of population health
Economic, political and sociocultural conditions
Public health and medical care
Part 2. Zooming in: The rise and fall of diseases
Health problems of pre-industrial societies
Violence and hunger
Great epidemics
Health problems of industrializing societies
Communicable diseases
Maternal, infant and perinatal mortality
Other health problems of industrializing societies
Health problems of affluent societies
Chronic diseases
Injuries
A new plague
Part 3. Synthesis and outlook
Why?
Why did European population health improve?
Why did some countries rush ahead or lag behind?
Outlook
Feathers of Icarus
The way ahead
By way of conclusion.Digital Access 2020 - PrintGene G. Hunder, Eric L. Matteson.Contents:
Dedication
Acknowledgments
1. Introduction
2. Rheumatology at Mayo Clinic Rochester
3. Rheumatology at Mayo Clinic Florida
4. Rheumatology at Mayo Clinic Arizona
5. Rheumatology at Mayo Clinic Health System
6. Rheumatology education
7. Rheumatology research
8. Concluding remarks
9. Contributions to rheumatology research
10. Contributions to rheumatology organizations and journals
11. Recognition of members of the staff
12. Biographies of staff members
13. Rheumatology trainees and advanced practice providers
14. Selections from rheumatology photo albums. - Digitaledited by Jeremy C. Ganz.Contents:
Ch. 1. Background knowledge in the early days
Ch. 2. Some physics from 550 BC and AD 1948
Ch. 3. Medical physics - particle accelerators - the beginning
Ch. 4. From particle accelerator to radiosurgery
Ch. 5. Stereotactic and radiosurgery concepts in Sweden
Ch. 6. Stereotactic and radiosurgery research in Sweden
Ch. 7. The journey from proton to gamma knife
Ch. 8. The earliest gamma unit patients
Ch. 9. Stockholm radiosurgery developing 1968-1982
Ch. 10. From Stockholm to Pittsburgh
Ch. 11. Changing times and early debates
Ch. 12. The development of dose planning
Ch. 13. Changing the gamma knife
Ch. 14. Conclusion and possible future trends
Index.Digital Access ScienceDirect 2014 - PrintJ. Marion Read and Mary E. Mathes.
- Printabstracted from the manuscript notes of the late Cecil Wall by the late H. Charles Cameron ; rev., annotated, and ed. by E. Ashworth Underwood.
- PrintGuido Silvestri, Mathias Lichterfeld, editors.Contents:
Molecular control of HIV and SIV latency
Assays to measure latency, reservoirs, and reactivation
The antiviral immune response and its impact on the HIV-1 reservoir
Nonhuman primate models for studies of AIDS virus persistence during suppressive combination antiretroviral therapy
SIV latency in macrophages in the CNS
Mathematical models of HIV latency
Residual immune activation and latency
Immune interventions to eliminate the HIV reservoir
Cell and gene therapy for HIV cure. - DigitalMarc H V Van Regenmortel.Summary: This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.
Contents:
Part I.Immunochemistry
1 What is a B cell epitope
2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure-function relationships in immunology
3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes
4 Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition
Part II. Reductionism
5 Reductionism and the search for structure-function relationships in antibody molecules
6 Reductionism and complexity in molecular biology
7 Editorial: Biological complexity emerges from the ashes of genetic reductionism
8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking
10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking
11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology
12 Limitations to the structure-based design of HIV-1 vaccine immunogens
13 Two meanings of reverse vaccinology and the empirical nature of vaccine science
14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine
15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013
16 Editorial: Paradigm changes are required in HIV vaccine research
17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine
18 More surprises in the development of an HIV vaccine
19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine?
20 Old a nd New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016
21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory
22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV
23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design
24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?.Digital Access Springer 2019 - Digital/PrintCraig Meyers, editor.Summary: In this book, leading experts examine the clinical and biological aspects of viruses known to play a role in the oncogenesis of AIDS-associated cancers and non-AIDS-defining malignancies more commonly observed in HIV-infected individuals. Among the malignancies considered are those associated with Kaposi sarcoma-associated herpesvirus (KSHV) or Epstein-Barr virus (EBV), Merkel cell carcinoma due to Merkel cell polyomavirus (MCPyV), human papillomavirus (HPV)-associated anogenital and oropharyngeal cancers, and hepatitis B and C virus (HBV/HCV)-associated liver cancers. It also provides detailed information on the molecular biology of the causative viral agents and guidance on the specific treatment required in this special population. Covering all the important advances in our understanding made since the first edition was published in 2007, including the discovery and characterization of MCPyV, which brought the number of known human oncoviruses to seven, this new edition is a valuable resource for members of the scientific and healthcare community and active researchers in this field.Digital Access Springer 2019
- DigitalZunyou Wu, Yu Wang, Roger Detels, Marc Bulterys, Jennifer M. McGoogan, editors.Summary: With HIV becoming the leading cause of infectious-disease mortality in Mainland China, this book focuses on tackling HIV/AIDS in the face of rapid political and economic change in China. Featuring contributions by over a dozen leading figures in the field, this book is the go-to text for any student or reader interested in how national and international organizations are attempting to control this epidemic. The book includes chapters on the epidemiology, treatment, and prevention of HIV, as well as several chapters that discuss in detail specific provincial- and national-level programs to control and treat HIV. It chronicles the Chinese governments amazing about-face, as it replaced underfunded, non-evidence based policy decisions with successful, science-based approaches to disease control and prevention, including the adoption of once controversial needle-exchange programs and the establishment of a national HIV/AIDS data registry. It measures the success of national policy decisions, the implementation of treatment policies, and discusses the difficulty of accessing high-risk communities, including people who inject drugs, sex workers, and men who have sex with men - groups not easy to reach, study, engage in prevention programs, or treatment, for fear of stigmatization and loss of social status. Further, it documents the spread of HIV to other provinces, and the tragedy that befell repeat plasma donors in Henan and other poor provinces, where reused or improperly sterilized lab equipment caused some villages to have epidemic-level incidence rates. This book represents a positive contribution to the field of AIDS research, making vital, new information available to an interested readership.
Contents:
Epidemiology
Prevention
Treatment
Comprehensive Program
Key Areas Response
Conclusion. - DigitalDigital Access v. 1-, 2003-
- Digital/PrintDigital Access Google Books 1999-
- DigitalDigital Access v. 1-, 2000-
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