BookHong Tang, editor.
Summary: This volume provides a state-of-the-art review of the key aspects of HBV. It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV. It also provides an update on cell and animal models, as well as molecular approaches. The respective chapters also cover the clinical management of hepatitis B and discuss future research directions, in particular, the identification of molecular targets for pharmacological intervention. Given its scope, the book offers a valuable resource for students, researchers, clinicians, and health practitioners in the fields of virology, infectious disease, public health etc. Dr Hong Tang is a Professor and Director of the Center of Infectious Diseases, West China Hospital of Sichuan University.
Contents:
Intro; Preface; Contents;
Chapter 1: Hepatitis B Virus Infection: Overview; 1 Discovery of HBV; 2 Epidemiology and Natural History of HBV Infection; 3 Biological Characteristics and Immunopathogenesis of HBV; 3.1 HBV Genome and Life Cycle; 3.2 HBV Transcription and Translation; 3.3 Immunopathogenesis of HBV; 4 Current Antiviral Drugs Against HBV and New Antiviral Drugs Under Development; 4.1 Current Antiviral Drugs Against HBV; 4.2 Optimization Treatment Strategies Based on Current Antiviral Drugs; 4.3 Advances in the Development of New Anti-HBV Drugs 4.3.1 Direct Antiviral Drugs Against the Life Cycle of HBV4.3.2 Indirect Antiviral Drugs that Modulate Host Immune Response to Control CHB; References;
Chapter 2: HBV Genome and Life Cycle; 1 Introduction; 2 HBV Genome; 3 Viral Entry; 4 The Conversion of rcDNA to cccDNA; 5 The Expressions of Viral RNAs and Proteins; 6 Viral Capsid Assembly, Reverse Transcription, and rcDNA Formation; 7 Viral Budding; 8 Conclusion; References;
Chapter 3: The Regulation of HBV Transcription and Replication; 1 Introduction; 2 Transcription of the HBV Genome 3 Cis-Acting Transcriptional Regulatory Sequence Elements and Trans-Acting DNA-Binding Proteins4 Role of Liver-Enriched Transcription Factors in HBV Transcription, Replication, and Tissue Tropism; 5 Redundant Functions for Nuclear Receptors in HBV Biosynthesis; 6 Regulation of HBV Biosynthesis by Transcriptional Coactivators and Corepressors; 7 Transcriptional Regulation of HBV Replication In Vivo; 8 Conclusions; References;
Chapter 4: Immunopathogenesis of HBV Infection; 1 Introduction; 2 Viral Factors Leading to HBV Persistence; 2.1 HBV Genetic Variants 2.2 Impact of Viral Load on HBV Persistence3 Host Genetics; 4 Innate Immune Responses; 4.1 HBV Recognition by Innate Sensors; 4.2 HBV-Driven Inhibition of Innate-Signaling Pathways; 4.3 NK Cells; 4.4 Liver Macrophages; 4.5 MDSC; 4.6 NKT; 4.7 MAIT; 5 Adaptive Immune Responses; 5.1 Antigen-Presenting Cells; 5.2 CD4+ T Cells; 5.3 CD8+ T Cells; 5.4 B Cells; 6 Liver Injury in HBV Infection; 6.1 HBV-Induced ER and Mitochondrial Dysfunctions; 6.2 HBV Surface Antigen Mutations in Fulminant Hepatitis B and Occult HBV Infection 6.3 HBV RNAs Deregulate miRNA Functions Leading to Pathological Consequences6.4 HBV X Protein Interferes with the Apoptosis Signaling to Promote Viral Proliferation and HCC Progression; 7 Immune-Tolerant Phase of HBV Infection; 8 Age-Dependent Immune Response to HBV Infection; 9 Maternal Effect on HBV Persistence: Induction of Trained Immunity in Human Neonates of HBV+ Mothers; 10 Conclusions; References;
Chapter 5: Cell Culture Models and Animal Models for HBV Study; 1 Introduction; 2 HBV Cell Culture Models; 2.1 HBV DNA Integrated Stable Cell Models; 2.2 HBV Infection Cell Models 2.3 HBV Recombinant cccDNA Transfection Cell Models