BookNayoung Kim, editor.
Contents:
Part 1. Epidemiology-Prevalence and Transmission routes of H. pylori
Part 2. Pathophysiology
1) Colonization of H. pylori in the stomach
2) Brief description of Pathophysiology
3) Immune mechanism
4) Change of acid secretion, ghrelin and leptin by H. pylori
5) H. pylori virulence factors
A: toxin (CagA, VacA, DupA, OipA, IceA)
B: genetic polymorphism of toxin and disease
6) Host factors: genetic polymorphism, etc
Part 3. Diagnosis
1) Serology
2) Histology
3) Culture
4) UBT
5) Stool antigen
6) Specific conditions
A: Children
B: Bleeding
Part 4. Symptom
1)Symptom of acute and chronic H. pylori infection
Part 5. Disease
1) Atrophic gastritis and Intestinal metaplasia
2) Functional dyspepsia
3) Peptic ulcer
4) MALToma
5) Gastric cancer
A: Synopsis and Epidemiology of gastric cancer
B1: Pathogenesis: i.Genetic alternation (mutations in tumor-related genes) induced by Activation-induced cytidine deaminase (AID)
B2: Pathogenesis: ii. Epigenetic mechanisms: aberrant DNA methylation, microRNA
B3: Pathogenesis:iii. Macrophage inhibitory factor (MIF)
B4: Pathogenesis: iv. Epidermal mesenchyme transition (EMT)
B5: Pathogenesis: v. ABO blood type
B6: Pathogenesis: vi. First relatives of gastric cancer
C: H. pylori-negative gastric cancer
6) Gastroesophageal reflux disease (GERD)
7) NSAID-induced gastropathy and H. pylori infection
8) Extraintestinal manifestations of H. pylori infection
A: Iron deficiency anemia
B: Idiopathic thrombocytopenic purpura
C: Heart disease
D: Atopy and allergy
Part 6. Antibiotic resistance
1) Synopsis of antibiotic resistance
2) Clarithromycin
3) Amoxicillin
4) Quinolone
5) Metronidazole
Part 7. Treatment
1) Synopsis of antibiotic treatment
2) Triple therapy
3) Quadruple therapy
4) Sequential therapy
5) Concomitant therapy
6) Tailored therapy based on antibiotic resistance
7) Levofloxacin or rifabutin based triple therapy
8) Probiotics
9) Treatment guidelines
10) Screening method of early gastric cancer
11) Recrudescence and reinfection
Part 8. Consequences of H. pylori eradication
1) Peptic ulcer disease
2) atrophic gastritis and Intestinal metaplasia
3) Gastric cancer
Part 9. The effect of H. pylori on the other microbiota of stomach
The effect of H. pylori on the other microbiota of stomach
Part 10. Animal model- H. pylori, H. felis.