BookAlexzander A.A. Asea, Punit Kaur, editors.
Summary: The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
SECTION I: ONCOGENIC ASPECTS OF HSP90
Chapter 1. Regulatory Roles of HSP90-rich Extracellular Vesicles
Chapter 2. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease
Chapter 3. Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer
Chapter 4. Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?
Chapter 5. Role of Heat Shock Protein 90 in Mammary Tumorigenesis
Chapter 6. Role of HSP90 Inhibitors in the Treatment of Cancer
Chapter 7. p53-HSP90 Axis in Human Cancer
Chapter 8. HSP90 and its Inhibitors for Cancer Therapy: Use of Nano-delivery System to Improve its Clinical Application
Chapter 9. Hsp90 is a Pivotal Player in Retinal Disease and Cancer
Chapter 10. Targeting Hsp-90 Related Disease Entities for Therapeutic Development
Chapter 11. HSP90: A Key Player in Metal-Induced Carcinogenesis?
Section II: Biomolecular Aspects of HSP90
Chapter 12. Hsp90 and its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases
Chapter 13. Moonlighting Functions of Heat Shock Protein 90
Chapter 14. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target
Chapter 15. 'Complex World' of Hsp90 Co-chaperone R2TP
Chapter 16. Functions of SGT1, a Co-chaperone
Chapter 17. Sti1/Hop Plays a Pivotal Role in Hsp90 Regulation beyond Bridging Hsp70
Section III: HSP90 in Natural Products Development.-Chapter 18. Hsp90: A Target for Susceptibilities and Substitutions in Biotechnological and Medicinal Application
Chapter 19. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products
Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family
Section IV: Clinical Aspects of HSP90
Chapter 21. Hsp90 Chaperone in Disease
Chapter 22. Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis
Chapter 23. Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo
Chapter 24. Heat Shock Protein 90 in Severe Trauma
Chapter 25. HSP90
Is there an Unknown Role in Pain Neurobiology
Chapter 26. Heat Shock Protein 90 in Kidney Stone Disease
Chapter 27. HSP90 et al.
Chaperome and Proteostasis Deregulation in Human Disease.