BookAlexzander A.A. Asea, Punit Kaur, editors.
Summary: The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Contents:
SECTION I: BIOMOLECULAR ASPECTS OF HSP60
Chapter 1. HSP60: A Story as Long as Life on the Earth
Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60
Chapter 3. HSP60 Inhibitors and Modulators
Chapter 4. HSP60 as Modulators of Apoptosis
Chapter 5. Utilizing The Unique Architecture And Abilities of HSP60 In Drug Development
Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease
SECTION II: HSP60 AND CANCER
Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology
Chapter 8. Exosomal HSP60: a Tumor Biomarker?
Chapter 9. HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities
Chapter 10. Hsp60 Involvement During Carcinogenesis
SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS
Chapter 11. Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases
Chapter 12. HSP60 In Inflammatory Disorders
SECTION IV: HSP60 AND CARDIOVASCULAR DISEASES AND DISORDERS
Chapter 13. HSP60 In Atherosclerosis
Past, Present and Future
Chapter 14. Cardiac Myopathy In Conditional HSP60 Transgenic Mice
SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES
Chapter 15. Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment
Chapter 16. HSP60 In Modifications of Nervous System Homeostasis and Neurodegeneration
SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS
Chapter 17. HSP60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology
Chapter 18. Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy
Chapter 19. Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity
SECTION VII: HSP60 IN HUMAN HEALTH
Chapter 20. Role of HSP60 In The Steroidogenesis and Reproduction
Chapter 21. Heat Shock Protein 60 in Skin Diseases.