BookManorama Bhargava.
Summary: This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.
Contents:
Techniques in Cytogenetics
Techniques in Molecular Haematology
Part: I - Case Studies in Myeloid Malignancies
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Myelodysplastic Syndromes - Myeloproliferative Neoplasms
Myeloproliferative Neoplasms
Chronic Myeloid Leukemia
Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages
Part: II - Case Studies in Lymphoid Malignancies
Acute Lymphoblastic Leukemia
Chronic Lymphocytic Leukemia and Non Hodgkins Lymphoma
Part: III - Case Studies in Multiple Myeloma
Multiple Myeloma.