- Vaccination : a tool for the control of avian influenza : Verona, Italy, 20-22 March, 2007 : proceedings of a joint OIE/FAO/IZSVe conference co-organised with the European Commission — Vertigo : a clinical guide (100)
- Vertigo and balance disorders in children — Vitamin D-- physiology, molecular biology, and clinical applications. 2nd ed. (100)
- Vitamin D and cancer — VU/TEXT (40)
- 2014 SpringerKimitaka Kaga.Many congenitally deaf infants and children suffer vestibular failure, which produces problems with their postural control, locomotion, and gait. However it is known that these children can eventually catch up with their normal balance control status in terms of development and growth as a result of central vestibular compensation. In Vertigo and Balance Disorders in Children the author provides comprehensive and integrative information on the vestibular system. The materials presented range from the history of its study, basic anatomy and physiology of vestibular organs, and the mechanism of balance and motor function development, to clinical aspects of vestibular disorders including their evaluation and pediatric neurology. Although there have been books discussing postural responses of infants and children with vestibular disorders, this is the first to present the influence of peripheral vestibular disorders and central vestibular compensation comprehensively. This book will benefit not only practitioners in this field such as pediatric otolaryngologists, pediatricians, and neurologists treating both children and adults, but also clinical specialists such as neonatologists, physical therapists, and speech therapists, helping them to better care for patients with vestibular failure.
- 2013 SpringerThomas Brandt, Marianne Dieterich, Michael Strupp.Vertigo and Dizziness: Common Complaints, Second Edition revises and updates the first edition to reflect the advances that have taken place in this field. Valid epidemiological studies are now available on the prevalence and incidence of these illnesses. There have been improvements in diagnostic criteria and important new principles in the treatment of vertigo and balance disorders are outlined for use in clinical practice, supported by video examples. Practitioners are also given access to the wealth of new, scientifically interesting findings on the pathophysiology, etiology, signs and symptoms and current treatment of peripheral and central vestibular disorders as well as somatoform vertigo, summarised in concise and accessible form. Written by experts in the field, Vertigo and Dizziness: Common Complaints, Second Edition is a practical guide for physicians of different specializations who treat patients with vertigo including neurologists, ENT specialists, neuro-otologists, and neuro-ophthalmology and ophthalmology specialists as well as general medicine practitioners.
- 2014 SpringerDario Carlo Alpini, Antonio Cesarani, Guido Brugnoni."This book describes in detail rehabilitation protocols specific for those disorders that most frequently induce vertigo and dizziness. In particular, it highlights exercise protocols that will enable the best result to be obtained within the shortest time and with the most enduring therapeutic effect. Drawing on their personal experience, the authors describe physical exercises that will prove effective in delivering vestibular rehabilitation all over the world, regardless of the rehabilitation tools available. The protocol standardization and the reduction in instrumental rehabilitation mean that even though some individual tailoring is required, it will be possible to plan cost-effective rehabilitation within both the institutional and the private practice setting. The presented protocols cover vertigo in a wide range of conditions, including acute and chronic vestibular loss, vestibular ataxia, benign positional paroxysmal vertigo, Ménière's disease, dizziness in the elderly, whiplash-associated balance disorders, phobic postural vertigo, and autonomic vertigo. Helpful information is provided on clinical approach to vertigo and dizziness and on vestibular rehabilitation from Cawthorne-Cooksey onward. The quantification of rehabilitation outcome and the role of life-style counseling are also discussed. By documenting effective functional and therapeutic approaches and presenting guidelines for each balance disorder, Vertigo Rehabilitation Protocols will be an invaluable resource for neurologists, ENT physicians, orthopedists, and rehabilitation specialists."--Publisher's website.
- 2008/2009Garret Lance Hayes.
- 2013 SpringerYosef Yarden, Gabi Tarcic, editors.Clathrin-Mediated Endocytosis / Alexander Sorkin, Manojkumar A. Puthenveedu -- Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton / Tal Hirschhorn, Marcelo Ehrlich -- Oncogenic Signaling from the Plasma Membrane / Eli Zamir, Nachiket Vartak, Philippe I. H. Bastiaens -- Endocytosis in the Spatial Control of Polarised Cell Functions / Giorgio Scita, Andrea Disanza, Emanuela Frittoli -- Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer / Shreya Mitra, Gordon B. Mills -- Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer / Crislyn D'Souza-Schorey, Guangpu Li -- Efficient Enhancement of Signaling Capacity: Signaling Endosomes / Iwona Pilecka, Marta Miaczynska -- Nuclear Functions and Trafficking of Receptor Tyrosine Kinases / Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung -- Efficient Enhancement of Signalling Capacity: The Ubiquitin System / Daniela Hoeller, Ivan Dikic -- Molecular Mechanism of Ubiquitin-Dependent Traffic / Elena Maspero, Hans-Peter Wollscheid, Simona Polo -- Cbl as a Master Regulator of Receptor Tyrosine Kinase Trafficking / Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz -- Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes / Han Liu, Sylvie Urbé, Michael J. Clague -- RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer--Location Counts / Carine Joffre, Rachel Barrow, Ludovic Ménard -- Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells / Sergio Anastasi, Stefano Alemà, Oreste Segatto MD -- Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress / Tzipora Goldkorn, Simone Filosto, Samuel Chung -- Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion / Elena Rainero, Peter V. E. van den Berghe, Jim C. Norman -- Antibody-Mediated Receptor Endocytosis: Harnessing the Cellular Machinery to Combat Cancer / Gabi Tarcic, Yosef Yarden.
- 2009 SpringerToshihisa Murofushi, Kimitaka Kaga.
- 2015 SpringerStephen Wetmore, Allan Rubin, editors.Vestibular Migraine is a concise monograph that presents the scientific basis for the diagnosis and treatment of this common yet largely unrecognized cause of dizziness. Current knowledge of the features of the disorder is described, and clear guidance is provided on the differentiation of vestibular migraine from other conditions that induce dizziness, including M©♭ni©·reĺls disease. Symptomatic treatment and the various prophylactic options are discussed and evaluated, and advice is also included on long-term treatment and the circumstances under which treatment should be discontinued. Approximately one-third of migraineurs experience dizziness that sometimes occurs in conjunction with the headaches but often arises separately. The vestibular symptoms in this population vary in frequency, severity, and duration; they are described as spinning or lightheadedness or both and are often exacerbated by position change. Ear fullness, tinnitus, and hearing loss are frequent complaints. Vestibular migraine is diagnosed by carefully obtaining a history: there are no pathognomonic blood, urine, or imaging studies. This book will be of interest to all physicians and other health care providers who deal with dizzy patients, including internists, family physicians, neurologists, otolaryngologists, and trainees in those specialties, as well as nurse practitioners and physician assistants.
- 2014 SpringerBruno Colombo, Roberto Teggi, editors.This book provides a multidisciplinary approach to vestibular migraine and related syndromes in which dizziness is the most predominant feature. Starting from the neurological point of view, the pathophysiology, classification, neurophysiology, and therapy of migraine are discussed. Readers will learn how to recognize and properly treat vestibular migraine, which is often undiagnosed or misdiagnosed as Ménière's syndrome (a form of vertigo characterized by vertigo spells and hearing loss that presents comorbidity with migraine) or benign paroxysmal positional vertigo (in which patients experience brief episodes of vertigo, lasting from seconds to 1 minute, when they move their heads in a certain way). The described diagnostic and therapeutic strategies include the newest, state of the art approaches. Further aspects of migraine that are considered include hyperexcitability in the brain and the triad of migraine, dizziness, and anxiety. In addition, the imaging of migraine, and of vestibular migraine in particular, is discussed and clinical records are reported. Vestibular Migraine and Related Syndromes is based on the practical and clinical experiences of an authoritative group of well-known neurologists, ENT specialists, and neuro-otologists. It provides neurologists with a complete overview of relevant clinical features, otolaryngologists with clear descriptions of clinical aspects and the pathophysiology of migraine, and radiologists with guidance on the role of imaging techniques.
- 1998 NAP2000 NAP2004 NAPCommittee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Division of Health Promotion and Disease Prevention, Institute of Medicine.
- 2016 WileyF. Yvonne Schulman.
- 2015 Springer Protocolsedited by Mónica V. Cunha, João Inácio.
- 2013 CRCnetBASEIhtesham ur Rehman, Zanyar Movasaghi, Shazza Rehman."This book presents a variety of vibrational spectroscopic techniques, focusing on Raman and Fourier transform infrared (FTIR) spectroscopy and their use in noninvasive optical tissue diagnosis. It covers the most recent research in this area to create a unique database of different chemical bands and their assignments of spectral bands. The text explores the spectroscopic investigation of different tissues and samples, including breast tissue, lung tissue, and brain tissue. Based on their years of experience with various applications, the authors provide definitions of peak frequencies as well as other aspects of spectroscopy that could be helpful to a wide range of scientists"--Provided by publisher.
- 2012 SpringerKrishna R. Dronamraju, Clair A. Francomano, editors.Victor McKusick /; Krishna R. Dronamraju --; Family Life and Victor's Meeting the Unexpected /; Anne Bishop McKusick --; The McKusick Twins: A Personal Essay /; Vincent L. McKusick --; Personal Recollections of Victor /; Krishna R. Dronamraju --; Memories of Victor McKusick /; Don M. Long --; Memories of the Moore Clinic, 1960-1965 /; David J. Weatherall --; Cytogenetics and Early Days at the Moore Clinic with Victor McKusick /; Malcolm A. Ferguson-Smith --; Travels with Victor: Marfan Syndrome and Its Cousins /; Reed E. Pyeritz --; Homage for Victor McKusick /; Nicholas Avrion Mitchison --; How Did My Association with Victor Influence Me, My Career, and My Family? /; Digamber S. Borgaonkar --; The Assimilation of Classical Genetics into Human Genetics /; Elof Axel Carlson --; Genetic Studies in Isolated Populations: Victor McKusick's Contributions to Population Genetics /; Aravinda Chakravarti --; Victor A. McKusick and Medical Genetics Among the Amish /; Clair A. Francomano --; Dr. Victor A. McKusick and the Genetics of Dwarfism /; Clair A. Francomano and David L. Rimoin --; Clinical Genomicist in the Future of Medical Practice /; Edison T. Liu --; Victor McKusick and the History of Medical Genetics /; Peter S. Harper --; The Influence of Victor A. McKusick on the Development of Training in Medical Genetics in Europe and in the World /; Giovanni Romeo.
- 2011 ClinicalKeyLeslie H. Blumgart ; with laparoscopic video contributions from Carlos U. Corvera.Dr. Leslie H Blumgart has developed an extensive library of high-quality, narrated, and captioned videos that present history, radiologic evidence, and operative procedures-from major and minor resectional procedures to biliary and pancreatic anastomotic techniques. Dr. Carlos U. Corvera has worked with Dr. Blumgart to contribute laparoscopic alternatives to these innovative and landmark surgeries. On DVD, and in print, this multimedia resource provides detailed, practical instruction on this challenging area of surgery. Master difficult, complex, and lesser-known surgeries through more than 10 hours of high-quality procedural videos narrated by Dr. Leslie H. Blumgart-a pioneer in the field. See how an expert handles difficult cases from clear illustrations and step-by-step discussions of procedures, including Dr. Blumgart's personal techniques. Get coverage of major and minor resectional procedures, biliary tract and pancreatic resection, biliary and pancreatic anastomotic techniques, and more-including newly pioneered minimally invasive procedures from Dr. Carlos U. Corvera.
- 2013 ClinicalKey[edited by] Constantine T. Frantzides, Mark A. Carlson ; illustrations by DNA Illustrations, Inc.Anatomy and Physiology -- Diagnostic Evaluations -- Preoperative Management -- Postoperative Management -- General Postoperative Complications and How to Prevent Them -- Hemorrhoids -- Anal Fissure -- Abscess and Fistula -- Complex Colorectal Fistulas -- Pilonidal Disease and Hidradenitis Suppurativa -- Pilonidal Disease and Hidradenitis Suppurativa -- Screening for Colorectal Cancer -- Polyps -- Colon Cancer Evaluation and Staging -- Colon Cancer Evaluation and Staging -- Colon Cancer Evaluation and Staging -- Colorectal Cancer : Adjuvant Therapy and Surveillance -- Treatment of Metastatic or Recurrent Colorectal Cancer -- Anal Malignancies -- Miscellaneous Neoplasms -- Inflammatory Bowel Disease -- Surgical Management of Ulcerative Colitis -- Surgery for Crohn Disease -- Diverticulitis -- Lower Gastrointestinal Hemorrhage -- Radiation, Ischemic, and Infectious Colitides -- Large and Small Bowel Obstruction -- Intestinal Stomas and Their Complications -- Incontinence and Rectocele -- Rectal Prolapse -- Pruritus Ani and Other Perianal Dermatoses -- Colon and Rectal Trauma -- Uncommon Disorders.
- 2013 Thieme eNeurosurgeryEric S. Nussbaum.Surgical approaches to intracranial aneurysms -- Aneurysms of the anterior cerebral artery -- Paraclinoid aneurysms/carotid ophthalmic aneurysms -- Supraclinoid internal carotid artery aneurysms -- Aneurysms of the carotid bifurcation -- Aneurysms of the middle cerebral artery -- Aneurysms of the basilar artery -- PICA aneurysms -- Special considerations -- General principles of aneurysm surgery : nuances and advice for successful outcomes and complication avoidance.
- 2017 ClinicalKeyedited by Alfredo Quiñones-Hinojosa ; video editor Jordina Rincon-Torroella.Introduction. Operating room requirements for brain tumor surgery -- Awake craniotomy and speech mapping for gliomas -- Cortical/subcortical motor mapping for gliomas -- Trans-sulcal versus transcortical resection of subcortical metastases -- Deep intra-axial tumors -- Brainstem tumors -- Cerebellar tumors -- Cervicomedullary tumors -- Supracerebellar infratentorial approach -- Intraoperative assessment of extent of resection -- Convexity and parasagittal meningiomas -- Falcine and falcotentorial meningiomas -- Posterior fossa meningiomas -- Transcortical approach to the lateral ventricles -- Transcallosal approach for intraventricular tumors -- Telovelar approach -- Endoscopic approach to the ventricles -- Pterional craniotomy -- Orbitozygomatic craniotomy -- Supraorbital osteotomy : eyelid and eyebrow incisions -- Subfrontal and extended subfrontal craniotomy/transbasal approach -- Retrosigmoid versus extended retrosigmoid approach -- The far lateral approach -- Principles and anatomy in endoscopic endonasal surgery -- Pituitary adenomas -- Surgical treatment of craniopharyngiomas -- Clival chordomas -- Techniques for skull base reconstruction in endoscopic surgery -- Combined subfrontal and endonasal approach -- Combined transconjunctival and endonasal approach -- Combined transmaxillary and subfrontal approach -- Midline anterior skull base meningiomas -- Sphenoid wing meningiomas -- Parasellar tumors -- Invasive pituitary adenomas -- Approaches to the temporal bone : basic principles -- Approaches to the orbit -- Vestibular schwannomas -- Foramen magnum meningiomas.
- 2017 ClinicalKeyedited by Bobby Korn, Don Kikkawa.Foundations of oculofacial plastic surgery -- Chalazion incision and drainage -- Upper blepharoplasty -- Asian upper blepharoplasty -- Asian eyelid crease formation (double eyelid operation) by suture ligation method -- Revision of Asian upper eyelid crease -- Root Z-epicanthoplasty -- Mustardé's epicanthoplasty -- Transconjunctival lower blepharoplasty with fat redraping -- Transcutaneous lower blepharoplasty with orbitomalar suspension and fat redraping -- Ptosis repair by external levator advancement -- Ptosis repair by small incision external levator advancement -- Ptosis repair by conjunctival Müller's muscle resection -- Congenital ptosis repair by levator resection -- Frontalis suspension with silicone rod -- Repair of conjunctival prolapse -- Upper eyelid retraction repair -- Levator extirpation and frontalis suspension -- Upper eyelid loading with platinum weight -- Direct browplasty -- Internal browplasty -- Endoscopic browplasty -- Pretrichial browplasty -- Facelift by minimal access cranial suspension (macs) -- Ectropion repair by retractor reinsertion and lateral tarsal strip -- Ectropion repair by medial spindle -- Ectropion repair with full thickness skin grafting -- Canthus sparing drill hole canthoplasty -- Entropion repair by transconjunctival approach -- Entropion repair by Wies procedure -- Entropion repair by posterior tarsotomy -- Epiblepharon repair -- Limited upper eyelid protractor myectomy -- Lower eyelid retraction repair with porcine acellular dermal collagen matrix -- Lower eyelid retraction repair with dermis fat -- Lower eyelid retraction repair with hard palate grafting -- Lower eyelid wedge resection and reconstruction -- Lower eyelid reconstruction with periosteal flap and upper eyelid rotational flap -- Lower eyelid reconstruction with semicircular flap -- Lower eyelid reconstruction with Hughes' tarsoconjunctival flap -- Lower eyelid reconstruction with Mustardé flap -- Lateral canthal reconstruction with rhomboid flap -- Upper eyelid reconstruction with cutler-beard flap and free tarsal graft -- Temporal artery biopsy -- Conjunctival pillar tarsorrhaphy -- Lateral tarsorrhaphy -- Autologous fat transfer to the tear trough -- Hyaluronic acid gel filler to the inferior periorbita -- Botulinum toxin treatment for lateral canthal rhytids (crow's feet) -- Botulinum toxin treatment for glabellar rhytids -- Botulinum toxin treatment for forehead rhytids -- Thermal conjunctivoplasty -- Endoscopic dacryocystorhinostomy -- Endoscopic dacryocystorhinostomy with osteotome -- Endoscopic dacryocystorhinostomy with lacrimal sac biopsy -- Endoscopic revision of failed dacryocystorhinostomy -- Endoscopic dacryocystorhinostomy with intranasal flap suturing -- Endoscopic dacryocystorhinostomy with balloon dacryoplasty -- Endoscopic conjunctivodacryocystorhinostomy -- Bicanalicular intubation with silicone stent -- Treatment of canaliculitis -- Silicone stent intubation with pigtail probe -- Snip punctoplasty -- Three wall orbital decompression -- Lateral orbitotomy with rim removal -- Inferior orbitotomy for cavernous hemangioma -- Orbital fracture repair -- Orbital floor reconstruction in silent sinus syndrome -- Transcaruncular approach to ethmoidal artery ligation -- Reposition of prolapsed lacrimal gland -- Optic nerve sheath fenestration -- Evisceration with orbital implant placement -- Enucleation and orbital implant placement -- Orbital exenteration -- Orbital implant exchange with dermis fat graft -- Multidisciplinary management of orbital varix.
- 2014 SpringerMartin Keuchel, Friedrich Hagenmüller, Hisao Tajiri, editors.This book is simultaneously a superb atlas and a detailed guide to all aspects of video capsule endoscopy. History, technique, performance, reading, indications, contraindications, outcomes, complications and alternative methods are described systematically by a large panel of experts. In addition, the full range of small bowel diseases, from the common to the rare, are described and illustrated using a unique and exhaustive collection of capsule endoscopy images that are accompanied by corresponding images of enteroscopy, surgery, radiology and histology whenever possible. The newest technology of colon capsule endoscopy is included and exciting potential future developments are also considered. This book will be indispensable for all who use the technique or are considering establishing a video capsule endoscopy service.
- 2007 SpringerWolfgang Regal, Michael Nanut.
- 2007 SpringerHolly Johnson, Natalia Ollus, Sami Nevala.
- 2013 Kargervolume editors, Claudia García-Moreno, Anita Riecher-Rossler.Violence against women, its prevalence and health consequences / Claudi García-Moreno, Heidi Stöckl -- Gender-based violence in the Middle-East : a review / Josyan Madi Skaff -- Violence against women in Latin America / Silvia Lucía Gaviria -- Violence against women in South Asia / Unaiza Niaz -- Violence against women in Europe : magnitude and the mental health consequences described by different data sources / Karin Helweg-Larsen -- Intimate partner violence as a risk factor for mental health problems in South Africa / Rachel Jewkes -- Intimate partner violence and mental health / Sian Oram, Louise M. Howard -- Sexual assault and women's mental health / Sandra L. Martin, Angela M. Parcesepe -- Child sexual abuse of girls / Harriet L. MacMillan, C. Nadine Wathen -- Sexual violence and armed conflict : a systematic review of psychosocial support interventions / Vivi Stavrou -- Abuse and trafficking among female migrants and refugees / Marianne Kastrup -- Abuse in doctor-patient relationships / Werner Tschan -- Workplace harassment based on sex : a risk factor for women's mental health problems / Lilia M. Cortina, Emily A. Leskinen -- Violence against women and suicidality : does violence cause suicidal behaviour? / Karen M. Devries, Maureen Seguin -- Violence against women suffering from severe psychiatric illness / Marta B. Rondon -- Violence against women and mental health / Claudia García-Moreno, Anita Riecher-Rössler.
- 2015 SpringerJutta Lindert, Itzhak Levav, editors.Violence is one of the most important challenges, not only for public health systems, but also for public mental health. Violence can have immediate as well as long-term and even transgenerational effects on the mental health of its victims. This book provides a comprehensive and wide-ranging assessment of the mental health legacy left by violence. It addresses the issues as they affect states, communities and families, in other words at macro-, meso-, and microlevels, beginning by describing the impact of violence on neurobiology and mental health, as well as the spectrum of syndromes and disorders associated with different forms of violence. ℗l The work moves on to tackle violence at the international and intranationalĺllevel before zeroing in on the nature of violence in communities such as villages or city districts. It also examines the results of violence in the family. Each type of violence has distinct effects on mental health, and in each chapter specific groups are explored in depth to demonstrate the heterogeneity of violence as well as the diversity of its outcomes in the realm of public mental health. Finally, the book addresses the notion of undoing violenceĺl by detailing case studies of effective interventions and prevention occurring in countries, communities and families. These cases give us pause to reflect on the nature of resilience and dignity in the context of violence and mental health. All the chapters have been written by leading authors in the field and provide a state-of-the-art perspective. The authors, from different fields of expertise, facilitate interdisciplinary and international insights into the impact of violence on mental health.
- 2013 Springeredited by Stefan Pöehlmann, PhD, Graham Simmons, PhD.For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi-faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogenesis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.Also available: Print – 2013
- 2009 Springeredited by Craig E. Cameron, Matthias Gotte, Kevin D. Raney.
- 2005 ScienceDirectColin R. Howard.Also available: Print – 2005
- 2014 CRCnetBASEedited by Sunit K. Singh, Daniel Ruzek.Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.
- 2010 Springeredited by Maureen M. Jonas.Hepatitis A in children -- Epidemiology and natural history of hepatitis B in children -- Treatment of chronic hepatitis B in children -- Epidemiology and natural history of hepatitis C in children -- Treatment of chronic hepatitis C in children -- Hepatitis D and hepatitis E in children -- Hepatitis in children due to Non-A-E viruses -- Immunoprophylaxis of hepatitis A and hepatitis B in children -- Primary care of children with viral hepatitis: diagnosis, monitoring and general management.
- 2014 Wileyedited by Sunit K. Singh.A timely exploration of the impact of global change on the emergence, reemergence, and control of vector-borne and zoonotic viral infections From massively destructive ""superstorms"" to rapidly rising sea levels, the world media is abuzz with talk of the threats to civilization posed by global warming. But one hazard that is rarely discussed is the dramatic rise in the number and magnitude of tropical virus outbreaks among human populations. One need only consider recent developments, such as the spread of chikungunya across southern Europe and dengue in Singapore, Brazil, and the so
- 2014 SpringerR.A. Kaslow, L.R. Stanberry, J.W. LeDuc (eds.).Striking changes have occurred in the world since the publication of the last edition of Viral Infections of Humans. The global population is rapidly approaching 8 billion; climate change is leading to the introduction of new hosts, vectors and virus diseases heretofore never seen in many parts of the world; technological advances have revolutionized the ability to recognize and characterize viruses new and old; vaccines are altering the epidemiological landscape of the diseases they target, in some cases raising the hope of their eradication; and remarkably powerful computational tools are enabling not only detection of outbreaks of disease much sooner than in the past but also, through complex mathematical modeling, more accurate prediction of their potential impact. The new Fifth Edition of Viral Infections of Humans captures both the excitement and frustration of the dynamic struggle between humankind and the viruses that continue to cause immense suffering. It presents the latest concepts, methods, and technologies in epidemiology, detection, investigation, modeling, and intervention. Updated and entirely new chapters by dozens of experts across the field provide analytic summaries of current knowledge of viruses and prions causing acute syndromes, chronic illnesses, and/or malignancies. In sum, this ambitiously expanded volume offers a uniquely comprehensive perspective on viruses in humans, from agents of classic diseases (e.g., hepatitis, measles, polio, rabies, and yellow fever), to those with greatest pandemic impact (e.g., influenza and human immunodeficiency virus), to those discovered relatively recently (e.g., henipavirus, metapneumovirus, and norovirus). The new Fifth Edition of Viral Infections of Humans is an invaluable reference for students, fellows and established professionals in the fields of microbiology, public health and infectious disease epidemiology, medicine, and health policy.
- 2013 SpringerAlan C. Jackson, editor.Machine generated contents note: pt. I Encephalitis -- Measles Virus Infection and Subacute Sclerosing Panencephalitis / Kalbiye Yalaz -- Epstein-Barr Virus and Cytomegalovirus Infections / Alex Tselis -- Herpes Simplex Virus Meningoencephalitis / Israel Steiner -- Progressive Multifocal Leukoencephalopathy / Allen J. Aksamit -- Varicella Zoster Virus Infections / Don Gilden -- pt. II Meningitis/Encephalitis/Poliomyelitis -- Enterovirus Infections / Burk Jubelt -- pt. III Retroviruses -- Human Immunodeficiency Virus Infection/AIDS / William Tyor -- Human T-Cell Lymphotropic Virus Type 1 Infection / Raya Massoud -- pt. IV Viral Zoonoses -- Rabies / Alan C. Jackson -- West Nile Virus Infection / Marc Fischer -- Japanese Encephalitis Virus Infection / Tom Solomon -- Chikungunya Virus Infection / Philippe Gasque -- Nipah Virus Infection / Chong-Tin Tan -- Viral Hemorrhagic Fevers / Marylou V. Solbrig -- pt. V Unconventional Agents -- Prion Diseases / Valerie L. Sim.
- 2012 SpringerMichael G. Rossmann, Venigalla B. Rao, editors.Viruses: sophisticated biological machines / M.G. Rossmann and V.B. Rao -- F(1)-ATPase: A prototypical rotary molecular motor / K. Kinosita, Jr. -- Principles of virus structural organization / B.V. Prasad and M.F. Schmid -- Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography / J. Chang ... [et al.] -- Contractile tail machines of bacteriophages / P.G. Leiman and M.M. Shneider -- Long noncontractile tail machines of bacteriophages / A.R. Davidson ... [et al.] -- Short noncontractile tail machines: adsorption and DNA delivery by podoviruses / S.R. Casjens and I.J. Molineux -- Infection of cells by alphaviruses / D.T. Brown and R. Hernandez -- Influenza virus entry / M. Luo -- Molecular mechanisms of HIV entry / C.B. Wilen, J.C. Tilton and R.W. Doms -- Bunyavirus: structure and replication / T.S. Guu, W. Zheng and Y.J. Tao -- Viral polymerases / K.H. Choi -- Chaperonin-mediated folding of viral proteins / Z.L. Hildenbrand and R.A. Bernal -- Building the machines: scaffolding protein functions during bacteriophage morphogenesis / P.E. Prevelige and B.A. Fane -- Bacteriophage HK97 capsid assembly and maturation / R.W. Hendrix and J.E. Johnson -- Lipid-containing viruses: Bacteriophage PRD1 assembly / S.J. Butcher, V. Manole and N.J. Karhu -- Assembly of large icosahedral double-stranded RNA viruses / M.M. Poranen and D.H. Bamford -- The papillomavirus virion: a machine built to hide molecular Achilles' heels / C.B. Buck and B.L. Trus -- Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions / G. Cardone ... [et al.] -- Assembly and architecture of HIV / B.K. Ganser-Pornillos, M. Yeager and O. Pornillos -- Condensed genome structure / L.W. Black and J.A. Thomas -- The bacteriophage DNA packaging machine / M. Feiss and V.B. Rao -- The dsDNA packaging motor in Bacteriophage o29 / M.C. Morais -- Single-molecule studies of viral DNA packaging / Y.R. Chemla and D.E. Smith -- Genome gating in tailed bacteriophage capsids / P. Tavares, S. Zinn-Justin and E.V. Orlova -- Packaging in dsRNA Viruses / L. Mindich -- Mechanism of RNA packaging motor / E.J. Mancini and R. Tuma -- Helical viruses / G. Stubbs and A. Kendall.Also available: Print – 2012
- 2011 CRCnetBASENicole F. Steinmetz, Marianne Manchester.Ch. 1. An introduction to VNPs and nanotechnology -- ch. 2. Overview of the manifold VNPs used in nanotechnology -- ch. 3. Production of VNPs, VLPs, and chimeras -- ch. 4. The art of bioconjugation : functionalization of VNPs -- ch. 5. Encapsulating materials within VNPs -- ch. 6. VNPs as templates for materials synthesis -- ch. 7. Playing "nano-lego" : VNPs as building blocks for the construction of multi-dimensional arrays -- ch. 8. VNPs as tools for nanomedicine -- ch. 9. Summary and outlook.
- 2007Neal Nathanson ; co-authors, Rafi Ahmed ... [et al.].
- edited by Lawrence C. Kuo, David B. Olsen, Steven S. Carroll.Also available: Print – 1996
- 2009 SpringerUwe Lendeckel, Nigel M. Hooper, editors.
- 2011Nathan Wolfe.The author, a Stanford biologist reveals the surprising origins of the world's most deadly viruses, and how we can overcome catastrophic pandemics. He discusses the complex interactions between humans and viruses, and the threat from viruses that jump from species to species. He tells the story of how viruses and human beings have evolved side by side through history; how deadly viruses like HIV, swine flu, and bird flu almost wiped us out in the past; and why modern life has made our species vulnerable to the threat of a global pandemic. His research missions to the jungles of Africa and the rain forests of Borneo have earned him the nickname "the Indiana Jones of virus hunters," and in this book he takes readers along on his groundbreaking and often dangerous research trips to reveal the surprising origins of the most deadly diseases and to explain the role that viruses have played in human evolution. In a world where each new outbreak seems worse than the one before, he points the way forward, as new technologies are brought to bear in the most remote areas of the world to neutralize these viruses and even harness their power for the good of humanity. His provocative vision of the future will change the way we think about viruses, and perhaps remove a potential threat to humanity's survival. -- Provided by publisher.
- 2007 Springervolume editors: Elisabeth Waigmann, Manfred Heinlein.
- 2013 Springer Protocolsedited by Riccardo Brambilla, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.Lentiviral vectors as research tools in neurobiology: design and production / Alessandro Papale and Riccardo Brambilla -- Recombinant adenovirus in neurobiology / Qian Li and Tong-Chuan He -- Adeno-associated virus-based vectors / Nathalie Dutheil and Erwan Bezard -- Herpes simples virus 1 (HSV-1)-based vectors / Aldo Pourchet, Matias E. Melendez, Anna Greco, and Alberto L. Epstein -- Aphavirus-based vectors / Kenneth Lundstrom -- Viral vectors to study synaptic function / Hélène Marie -- Using viral vectors to study the memory trace in mice / Asim J. Rashid, Chen Yan, and Sheena A. Josselyn -- Development of cell-type-specific viral vectors to tease apart the neural circuitry that contributes to drug addiction / Susan M. Ferguson and John F. Neumaier -- Using viral-mediated gene transfer to study depressive-like behavior / Amy R. Furay and John F. Neumaier -- Gene therapy for parkinson's disease / Erika Elgstrand Wettergren, Luis Quintino, Giuseppe Manfré, and Cecilia Lundberg -- Lentiviral vectors in huntington's disease research and therapy / Aurélie Delzor, Noëlle Dufour, and Nicole Déglon -- Application of viral vectors to motor neuron disorders / Elisabeth Dirren and Bernard L. Schneider -- In vivo gene silencing by virally delivered MicroRNA / Eugenia V. Gurevich, Mohamed R. Ahmed, and Yonatan Carl -- Viral manipulation of neural stem/precursor cells / Nunzio Iraci, Giulia Elisabetta Tyzack, Chiara Cossetti, Clara Alfaro-Cervello, and Stefano Pluchino -- Viral vector-based techniques for optogenetic modulation in vivo / Mathias Mahn, Shiri Ron, and Ofer Yizhar -- Viral vectors for optogenetics of hypothalamic neuropeptides / H. Sophie Knobloch, Alexander Charlet, Ron Stoop, and Valery Grinevich -- Viral vectors in primate research: examples from parkinson's disease research / Grégory Porras, Benjamin Dehay, and Erwan Bezard.
- 2011 Springer Protocolsedited by Otto-Wilhelm Merten, Mohamed Al-Rubeai.Introduction to viral vectors -- Introduction to gene therapy : a clinical aftermath -- Host cells and cell banking -- Overview of current scalable methods for purification of viral vectors -- Methods to construct recombinant adenovirus vectors -- Manufacturing of adenovirus vectors : production and purification of helper dependent adenovirus -- Manufacturing of retroviruses -- Lentiviral vectors -- Adeno-associated viruses -- Manufacturing of adeno-associated viruses, for example: AAV2 -- Vector characterization methods for quality control testing of recombinant adeno-associated viruses -- Baculoviruses mediate efficient gene expression in a wide range of vertebrate cells -- Herpes simplex virus type 1-derived recombinant and amplicon vectors -- Manufacture of measles viruses -- In vivo gene delivery into hCD34+ cells in a humanized mouse model -- In vivo evaluation of gene transfer into mesenchymal cells (in view of cartilage repair) -- Ethical consideration -- Clinical trials of GMP products in the gene therapy field.
- 2008 SpringerBrian L.D. Coghlan, Leon P. Bignold.
- 2013 SpringerMaxwell Bennett.Sexual abuse, literay genius and a mind gone awry -- Development of early 20th century psychiatry and its failure -- Freud, the subconscious and Virginia Woolf -- Virginia Woolf's suicide -- Neuropsychiatry and suicide -- Brain networks, hormones, and genes implicated in depression -- Pathology of synapses in brain networks implicated in depression -- On the mechanism of action of an anti-depressant -- On the identification of drugs modulating epigenetic mechanisms in depression -- Brain networks in psychosis -- On mental illness -- Mind, mental illness and the stream of consciousness.
- v. 1, pt. 1-<2>, <1978>Gueh-Djen Hsiung, Robert H. Green, section editors.
- 2009 CRCnetBASEedited by Michael J. Thali, Richard Dirnhofer, Peter Vock.A term coined by noted forensic pathologist Richard Dirnhofer, virtopsy refers to 'virtual autopsy', a modality that employs a spectrum of technologies including computed tomography, magnetic resonance imaging and spectroscopy, and 3D photogrammetry and surface scanning. This title reveals a comprehensive summary of the virtopsy procedure.
- 2010 SpringerP. Lefere, S. Gryspeerdt (eds.) ; with contributions by Y. Arai ... [et al.] ; foreward by A.L. Baert.Why we do CTC : screening for colorectal cancer / Richard M. Mendelson -- The performance of CTC / Didier Bielen -- Starting CT colonography in your department / Darra Murphy, Alan O'Hare, and Helen Fenlon -- The eligible patient : indications and contraindications / M. Raquel Oliva, Ayodale S. Odulate, and Koenraad J. Mortele -- Patient preparation for CT colonography / J. Yee -- The prerequisite : faecal tagging / Philippe Lefere and Stefaan Gryspeerdt -- How to get the colon distended? / David Burling, Stuart Taylor, and Steve Halligan -- Right parameters / Andrea Laghi -- How to interpret CTC data : evaluation of the different lesion morphologies / Beth G. McFarland -- How to avoid pitfalls in imaging : causes and solutions to overcome false-negatives and false-positives / Stefaan Gryspeerdt and Philippe Lefere -- 3D imaging : invaluable for the correct diagnosis? / Ayso H. De Vries and Jaap Stoker -- The challenge : detection of early-stage superficial colorectal lesions -- Gen Iinuma ... [et al.] -- Extracolonic findings / Francesca Turini, Francesca Cerri, and Emanuele Neri -- The future : computer-aided detection / H. Yoshida -- Quality and consistency in reporting CT colonography / Abraham H. Dachman, Piotr R. Obara, and Michael E. Zalis -- Virtual colonoscopy : beyond polyp detection? / T. Mang ... [et al.] -- Pictorial overview of normal anatomy, mimics of disease, and neoplasia using CT colonography / J.G. Fletcher, Fargol Booya, and Luis S. Guimaraes.
- Virtual scanning tunneling microscopy : a local spectroscopic probe of two-dimensional electron systems2012Adam Richard Sciambi.Two dimensional electron systems (2DESs) at semiconductor interfaces are a useful medium for studying complex physics due to their very low disorder and relative simplicity. Many interesting effects, such as the quantum Hall effect, have been discovered through transport measurements in such systems. Unfortunately, the interfacial nature of 2DESs and the related surface energy barrier means that directly accessing them from the surface is difficult. This has limited our understanding of theoretically-predicted, spatially-organized effects such Wigner-crystal microemulsions and quantum Hall stripes, which have been probed only indirectly. In this dissertation, we develop a new type of local probe that circumvents the surface barrier by tunneling into a 2DES from a second 2DES grown nearby. The interlayer tunneling happens directly below a scanned metal tip outside the sample, behaving as a virtual tip in a system we call Virtual Scanning Tunneling Microscopy (VSTM). In the first half of the dissertation, we discuss a novel mechanism for tuning tunneling locally between two 2DESs. Its premise is that raising a quantum potential well next to an adjacent barrier is energetically similar to lowering the barrier relative to a fixed well. A lower barrier leads to the quantum well wave function extending into it and to increased tunneling into a second quantum well on the opposite side. We characterize this mechanism in a GaAs-AlGaAs heterostructure as a new type of transistor. In the second half of the dissertation, results from a working VSTM system are presented, with local interlayer tunneling revealing hidden features in the interfaces below the surface.
- 2011Elias Aboujaoude."Whether sharing photos or following financial markets, many of us spend a shocking amount of time online. While the Internet can enhance well-being, [Stanford psychiatrist] Elias Aboujaoude has spent years treating patients whose lives have been profoundly disturbed by it. Part of the danger lies in how the Internet allows us to act with exaggerated confidence, sexiness, and charisma. This new self, which Aboujaoude dubs our "e-personality," manifests itself in every curt email we send, Facebook "friend" we make, and "buy now" button we click. Too potent to be confined online, however, e-personality traits seep offline, too, making us impatient, unfocused, and urge-driven even after we log off. This first scrutiny of the virtual world's transformative power on our psychology shows us how real life is being reconfigured in the image of a chat room, and how our identity increasingly resembles that of our avatar"--From publisher description.
- 2008Anna Brotcke Zumsteg.
- 2016 Am Soc Microbioledited by Indira T. Kudva, Nancy A. Cornick, Paul J. Plummer, Qijing Zhang, Tracy L. Nicholson, John P. Bannantine, Bryan H. Bellaire.Presents a compilation of bacterial virulence strategies and cutting-edge therapies that have been unraveled in recent years. Serves as a textbook for graduate courses on bacterial pathogenesis. Also a useful resourse for veterinary scientists, food microbiologists, and other established researchers interested in pathogenesis.
- 2013 Springer Protocolsedited by Susanne M. Bailer, Diana Lieber.High-throughput yeast two-hybrid protocol to determine virus-host protein interactions / Hannah Striebinger, Manfred Koegl, and Susanne M. Bailer -- Analysis of protein-protein interactions using LUMIER assays / Sonja Blasche and Manfred Koegl -- Detection of protein interactions during virus infection by bimolecular fluorescence complementation / Stefan Becker and Jens von Einem -- Discovery of host-viral protein complexes during Infection / Daniell L. Rowles, Scott S. Terhune, and Ileana M. Cristea -- Screening for host proteins with pro- and antiviral activity using high-throughput RNAi / Samantha J. Griffiths -- High resolution gene expression profiling of RNA synthesis, processing, and decay by metabolic labeling of newly transcribed RNA using 4-thiouridine / Lars Dölken -- Isolation and characterization of pathogen-bearing endosomes enable analysis of endosomal escape and identification of new cellular cofactors of infection / Konstanze D. Scheffer, Ruth Popa-Wagner, and Luise Florin -- Computational Analysis of Virus-Host interactomes / Caroline C. Friedel -- Interspecies heterokaryon assay to characterize the nucleocytoplasmic shuttling of herpesviral proteins / Shuai Wang, Kezheng Wang, and Chunfu Zheng -- Detection of integrated herpesvirus genomes by fluorescence in situ hybridization (FISH) / Benedikt B. Kaufer -- Fast generation of stable cell lines expressing fluorescent marker molecules to study pathogen induced processes / Jens Bernhard Bosse, Jessica Ragues, and Harald Wodrich -- Determination of HSV-1 infectivity by plaque assay and a luciferase reporter cell line / Diana Lieber and Susanne M. Bailer -- Generation of a stable cell line for constitutive miRNA expression / Diana Lieber -- Applications for a dual fluorescent human cytomegalovirus in the analysis of viral entry / Kerstin Laib Sampaio, Gerhard Jahn, and Christian Sinzger -- High temporal resolution imaging reveals endosomal membrane penetration and escape of adenoviruses in real time / Ruben Martinez ... [et al.] -- Three-dimensional visualization of virus-infected cells by serial sectioning : an electron microscopic study using resin embedded cells / Martin Schauflinger, Clarissa Villinger, and Paul Walther -- 3D-tissue model for herpes simplex virus-1 infections / Ina Hogk, Steffen Rupp, and Anke Burger-Kentischer -- In vivo visualization of encephalitic lesions in herpes simplex virus type 1 (HSV-1) infected mice by magnetic resonance imaging (MRI) / Wali Hafezi and Verena Hoerr -- Detection of antigen-specific T cells based on intracellular cytokine staining using flow-cytometry / Tina Schmidt and Martina Sester -- Functional NK cell cytotoxicity assays against virus infected cells / Rebecca J. Aicheler and Richard J. Stanton -- Assessment of natural killer cell responses to human cytomegalovirus-infected macrophages / Zeguang Wu, Giada Frascaroli, and Thomas Mertens -- Analysis of cell migration during human cytomegalovirus (HCMV) infection / Stefania Varani and Giada Frascaroli -- Gene targeting in mice : a review / Hicham Bouabe and Klaus Okkenhaug -- Protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells / Hicham Bouabe and Klaus Okkenhaug -- Measurement of mouse cytomegalovirus-induced interferon-[beta] with immortalized luciferase reporter cells / Evgenia Scheibe ... [et al.].
- 2013Dorothy H. Crawford."AIDS was first described in 1981 and just under three years later the Human Immunodeficiency Virus (HIV) was discovered. Confirming that HIV causes AIDS--now accepted by virtually all scientists--took rather longer. But where did HIV come from? When did it first infect us? How did it manage to spread so widely?"--Book jacket.
- 2014 Springer Protocolsedited by Baochuan Lin and Banahalli Ratna.Genetic engineering and chemical conjugation of potato virus X / Karin L. Lee, Kerstin [and four others] -- Genetically engineering adenoviral vectors for gene therapy / Lynda Coughlan - Simulated digestion for testing the stability of edible vaccine based on Cucumber mosaic virus (CMV) chimeric particle display Hepatitis C virus (HCV) peptide / Antonella Vitti [and three others] -- Using phage as a platform to select cancer cell-targeting peptides / Xin Li and Chuanbin Mao -- Bacteriophage T4 capsid packaging and unpackaging of DNA and proteins / Julienne M. Mullaney and Lindsay W. Black -- Templated mineralization by charge-modified cowpea mosaic virus / Alaa A.A. Aljabali and David J. Evans -- Polyelectrolyte-modified cowpea mosaic virus for the synthesis of gold nanoparticles / Alaa A.A. Aljabali and David J. Evans -- Tobacco mosaic virus capsid protein as targets for the self-assembly of gold nanoparticles / Omar K. Zahr and Amy Szuchmacher Blum -- Tobacco mosaic virus assembled high aspect ratio surfaces / Adam D. Brown and James N. Culver -- Phage as a template to grow bone mineral nanocrystals / Binrui Cao, Hong Xu, and Chuanbin Mao -- Genetic engineering and characterization of cowpea mosaic virus empty virus-like particles / Frank Sainsbury [and five others] -- A programmable fluorescent viral nanoblock : sensing made easy in a single step / Carissa M. Soto -- Chemical modification of the inner and outer surfaces of tobacco mosaic virus (TMV) / Michael A. Bruckman and Nicole F. Steinmetz -- Engineered bacteriophage T4 nanoparticles for cellular imaging / Jinny L. Liu and Kelly L. Robertson -- Phage-displayed single domain antibodies as recognition elements / Ellen Goldman and Scott Walper -- Molecular targeted viral nanoparticles as tools for imaging cancer / Choi-Fong Cho [and five others].
- 2013 Springer Protocolsedited by Annette Becker.Virus-induced gene silencing (VIGS) in plants : an overview of target species and the virus-derived vector systems -- Rationale for developing new virus vectors to analyze gene function in grasses through virus-induced gene silencing -- Virus-induced gene silencing for rice using agroinoculation -- Utilizing virus-induced gene silencing for the functional characterization of maize genes during infection with the fungal pathogen ustilago maydis -- Analysis of developmental control genes using virus-induced gene silencing -- Virus-induced gene silencing in the rapid cycling columbine aquilegia coerulea Origami -- Virus-induced gene silencing of the alkaloid-producing basal eudicot model plant eschscholzia californica (California poppy) -- Virus-induced gene silencing using artificial miRNAs in nicotiana benthamiana -- The use of vigs technology to study plant-herbivore interactions -- Virus-aided gene expression and silencing using TRV for functional analysis of floral scent-related genes -- Virus-induced gene silencing in soybean and common bean -- Functional genomic analysis of cotton genes with agrobacterium-mediated virus-induced gene silencing -- Highly efficient virus-induced gene silencing in apple and soybean by apple latent spherical virus vector and biolistic inoculation -- VIGS : a tool to study fruit development in Solanum lycopersicum -- A protocol for VIGS in arabidopsis thaliana using a one-step TYMV-derived vector -- Virus-induced gene silencing in strawberry fruit.
- 2014 Future Mededitors, Franco M. Buonaguro, Luigi Buonaguro.Virus-like particles in vaccine development / Franco M. Buonaguro & Luigi Buonaguro -- Developments in virus-like particle-based vaccines for HIV / Luigi Buonaguro, Maria Tagliamonte, Maria Luisa Visciano, Maria Lina Tornesello & Franco M Buonaguro -- Virus-like particle vaccines for the prevention of human papillomavirus infection / Joshua W. Wang, Richard B.S. Roden, Maria Lina Tornesello & Franco M. Buonaguro -- Virus-like particle-based vaccines against hepatitis C virus infection / Bertrand Bellier & David Klatzmann -- Evaluation of human rotavirus VLP vaccines in neonatal gnotobiotic pigs / Marli P. Azevedo, Anastasia N. Vlasova & Linda J. Saif -- Presenting heterologous epitopes with hepatitis B core-based virus-like particles / Sarah De Baets, Kenny Roose, Bert Schepens & Xavier Saelens -- SV40 virus-like particles as an effective delivery system and a vaccine platform / Masaaki Kawano, Masanori Matsui & Hiroshi Handa -- Plant-produced virus-like particle vaccines / Nunzia Scotti & Edward P. Rybicki -- Production of complex virus-like particles in insect cells / Fabiana Fernandes, Ana P. Teixeira, Nuno Carinhas, Manuel J.T. Carrondo & Paula M. Alves -- Index.
- Virus taxonomy : classification and nomenclature of viruses : ninth report of the International Committee on Taxonomy of Viruses2011 ScienceDirecteditors, Andrew M.Q. King, Elliot Lefkowitz, Michael J. Adams and Eric B. Carstens ; International Union of Microbiological Societies, Virology Division.The practical need to partition the world of viruses into distinguishable, universally agreed upon entities is the ultimate justification for developing a virus classification system. Since 1971, the International Committee on Taxonomy of Viruses (ICTV) operating on behalf of the world community of virologists has taken on the task of developing a single, universal taxonomic scheme for all viruses infecting animals (vertebrate, invertebrates, and protozoa), plants (higher plants and algae), fungi, bacteria, and archaea. The current report builds on the accumulated taxonomic construction of the eight previous reports dating back to 1971 and records the proceedings of the Committee since publication of the last report in 2005. Representing the work of more than 500 virologists worldwide, this report is the authoritative reference for virus organization, distinction, and structure.
- 2012 SpringerGunther Witzany, editor."Viruses are now considered to play major roles in the evolution of life. Because they have genes that are not found in any cellular organism they seem to be remnants of early stages of life on earth. Besides their disease causing features and actions as genetic parasites viruses have lifestyles that are clearly symbiotic and even symbiogenetic. Increasing empirical data suggest that some viruses such as endogenous retroviruses and non-retroviral RNA viruses and even DNA viruses prefer cellular genomes as habitat. They determine genetic host (group) identity and genetic host features. Viruses and virus-related modules such as mobile genetic elements and other repeat sequences identified in intronic regions of host genomes play important roles in gene regulation and genetic content (re)arrangement. This book exemplifies some astonishing key features of viruses acting as essential agents of life."--Publisher.
- 2013 SpringerAnton Kutikhin, Elena Brusina, Arseniy E. Yuzhalin.Will address an important, yet underrepresented, topic. The correlation between viruses and atherosclerosis has been a focal point of the authors work, for a number of years. This volume will explore the relationship between different viral strains and atherosclerosis. It will begin by describing the hypothesis and denoting the mechanisms of virus-driven atherosclerosis, then expanding on the subject by focusing on different virus strains from Herpes, to Epstein-Barr, to the triad of Hepatitis viruses, et al on a chapter-by-chapter basis. While there are books, albeit few, that cover particular viral strains and their relationship to cardiovascular diseases, this work will be unique in its scope by considering multiple strains of viruses, making it a repository of information on the topic; a truly comprehensive volume.
- 2014 SpringerS. David Hudnall, editor.Human Cancer Virology: An Historical Review -- Epstein-Barr Virus: Pathogenesis and Host Immune Response -- Epstein-Barr Virus: Epidemiology and Clinical Features of Related Cancer -- Hepatitis C Virus: Pathogenesis and Host Immune Response -- Hepatitis C Virus: Epidemiology and Clinical Features of Related Cancer -- Hepatitis B Virus: Pathogenesis and Host Immune Response -- Hepatitis B Virus: Epidemiology and Clinical Features of Related Cancer -- Human Papillomavirus: Pathogenesis and Host Immune Response -- Human Papillomavirus: Epidemiology and Clinical Features of Related Cancer -- Human T-Cell Leukemia Virus Type 1: Pathogenesis and Host Immune Response -- Human T-Cell Leukemia Virus Type 1: Epidemiology and Clinical Features of Related Cancer -- Kaposi's Sarcoma-Associated Herpesvirus: Pathogenesis and Host Immune Response -- Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Clinical Features of Related Cancer -- Merkel Cell Polyomavirus: Pathogenesis and Host Immune Response -- Merkel Cell Polyomavirus: Epidemiology and Clinical Features of Related Cancer.
- 2014 SpringerMei Hwei Chang, Kuan-Teh Jeang, editors.Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer - From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers. The susceptibility of high-risk hosts such as transplantation recipients is also addressed, and new vaccine developments are described.
- 2008James H. Strauss, Ellen G. Strauss.
- 2009 SpringerMarianne Manchester, Nicole F. Steinmetz, editors.Chemical modification of viruses and virus-like particles / E. Strable, M.G. Finn -- Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology / N.F. Steinmetz, T. Lin, G.P. Lomonossoff, J.E. Johnson -- Hybrid assembly of CPMV viruses and surface characteristics of different mutants / N.G. Portney, G. Destito, M. Manchester, M. Ozkan -- A library of protein cage architectures as nanomaterials / M.L. Flenniken ... [et al.] -- Biomedical nanotechnology using virus-based nanoparticles / G. Destito, A. Schneemann, M. Manchester -- Tumor targeting using canine parvovirus nanoparticles / P. Singh.Also available: Print – 2009
- 2014 SpringerArmando E. Fraire, Bruce A. Woda, Raymond M. Welsh, Richard L. Kradin, editors.Worldwide, infectious disease remains a major cause of morbidity and mortality. In developing countries, infection accounts for a substantial proportion of all recorded deaths. Likewise, in developed countries, pneumonia alone results in a large number of deaths. Along with bacteria, parasites and rickettsial organisms, viruses are responsible for many of the infections afflicting the human host. In the past decade alone, viruses that primarily target the lung have caused major respiratory illnesses including outbreaks of severe adult respiratory distress syndrome (SARS) and H1N1 influenza. This book is distinctive in that the entire spectrum of viral disease of the lung is conveniently compiled within a single volume. The epidemiologic, ultrastructural, immunologic, clinical and histopathologic features of well-known viral pathogens and newer emergent infectious agents are discussed. The book is organized in a classic fashion, starting with introductory material and sections on lung defenses and the taxonomic classification of pneumotropic viruses. The various acute viral pneumonias are then considered in a standard format in the main body of the book. Subsequent sections are devoted to the human immunodeficiency virus, viral lung disease in children and other viral-linked tumoral and nontumoral lung conditions. A chapter is also included on animal lung diseases caused by viruses. The text is supplemented by numerous color images.
- 2008This report draws attention to the threat of viruses as a risk to public health when they are present in food. Viruses play a major role in the burden of infectious intestinal disease and require special and separate attention because they behave differently from bacteria. In identifying the major routes of viral contamination of foods, this report seeks to highlight those areas which need immediate attention and provide guidance to both risk assessors and risk managers in understanding the challenges to be overcome in effectively addressing the problems associated with foodborne viruses.--Publisher's description.
- 2009 SpringerBernard Cygler.
- 2011 ScienceDirectJean-Pierre Barral, Alain Croibier.This work demonstrates a novel approach to visceral osteopathy. Basing their ideas on a sound understanding of the underlying A & P, Jean-Pierre Barral and Alain Croibier propose manipulation of the arteries to treat the intestines and other internal organs by increasing their blood flow. The arteries, elastic and muscular in structure, and the innumerable nerve filaments which surround them, react ideally to manual treatment. Rich in detailed, high quality illustrations, this book serves as both an anatomical reference and a guide to carrying out visceral vascular manipulations in the most effective way possible and is suitable for osteopathic physicians, osteopaths, chiropractors, physical therapists, manual therapists, physiotherapists, and massage therapists worldwide. Offers practical and clinically relevant information to all practitioners and therapists working in the field Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Prepared by experts of international renown Covers treatment of the main organs including the heart, pancreas, small intestine, colon and other abdominal structures as well as the regions of the neck, skull and pelvic cavity Serves as both an anatomical reference and a guide to carrying out visceral vascular manipulations in the most effective way possible Suitable for osteopathic physicians and osteopaths, chiropractors, physical therapists, manual therapists, physiotherapists, and massage therapists.
- 2000 NLMprepared by Karen Patrias.
- 2007 NLMprepared by Cynthia Burke, Karen Patrias.
- 2016 CogNetJohn E. Dowling and Joseph L. Dowling, Jr."Over the past fifty years, enormous progress has been made in understanding visual mechanisms and treating eye disorders. And yet the scientist is not always aware of the latest clinical advances and the clinician is often not up to date on the basic scientific discoveries. Writing in nontechnical language, John and Joseph Dowling, a neuroscientist and an ophthalmologist, examine vision from both perspectives, providing concise descriptions of basic visual mechanisms and related clinical abnormalities. Thus, an account of the photoreceptors is followed by a consideration of retinitis pigmentosa and macular degeneration; an explanation of the retina's function is followed by details of glaucoma and diabetic retinopathy. The authors begin with the cornea and lens, which project an image on the light-sensitive elements inside the eye, the photoreceptors, and how that process can be compromised by such disorders as cataracts and corneal disease. They go on to describe, among other things, how the photoreceptors capture light; retinal and visual cortical anatomy and physiology; and higher level visual processing that leads to perception. Cortical disorders such as amblyopia are discussed as well as specific deficits such as the inability to recognize faces, colors, or moving objects. Finally, they survey the evolution of our knowledge of vision, and speculate about future advances." -- Publisher's description
- 2011 CRCnetBASEedited by Penelope S. Suter, Lisa H. Harvey.Ch. 1. What is vision rehabilitation following brain injury? / Penelope S. Suter [and others] -- ch. 2. The interdisciplinary approach to vision rehabilitation following brain injury / Amy Berryman and Karen G. Rasavage -- ch. 3. Neural substrates of vision / Richard Helvie -- ch. 4. Spatial vision / Robert B. Sanet and Leonard J. Press -- ch. 5. Evaluation and treatment of visual field loss and visual-spatial neglect / Neil W. Margolis -- ch. 6. Egocentric localization : normal and abnormal aspects / Kenneth J. Ciuffreda and Diana P. Ludlam -- ch. 7. The use of lenses to improve quality of life following brain injury / Paul A. Harris -- ch. 8. Photophobia, light, and color in acquired brain injury / Cathy D. Stern -- ch. 9. The vestibular system : anatomy, function, dysfunction, assessment, and rehabilitation / Velda L. Bryan -- ch. 10. Evaluation and treatment of vision and motor dysfunction following acquired brain injury from occupational therapy and neuro-optometry perspectives / Janet M. Powell and Nancy G. Torgerson -- ch. 11. Acquired brain injury and visual information processing deficits / Sidney Groffman -- ch. 12. Vision examination of patients with neurological disease and injury / Thomas Politzer and Penelope S. Suter -- ch. 13. Successfully incorporating vision rehabilitation into the primary care vision practice / Allen H. Cohen -- ch. 14. Advocating for your patient in the legal system / Joseph Kiel.
- by Martin Willis.
- 2006 ProQuest SafariPaul Lomax, Tim Patrick ... [et al.].
- 2014 ScienceDirectby Bernhard Preim, Charl P. Botha.This book offers cutting-edge visualization techniques and their applications in medical diagnosis, education, and treatment. It includes algorithms, applications, and ideas on achieving reliability of results and clinical evaluation of the techniques covered, and treatment planning, guidance, and training.
- 2011Andreas Maximilian Rauschecker.Reading is the remarkable human ability to decode the sounds and meaning of language from an intricate combination of strokes of ink. This perceptual capacity is tolerant to changes in size, font, and other visual features of text. Transformations of the neural representation between many neural modules, including primary visual cortex (V1), other retinotopically organized areas, and language regions, are necessary for successful reading. An important focus of previous work has been on characterizing word representations in ventral occipito-temporal cortex, in particular in a left-hemisphere region known as the visual word form area (VWFA). To better understand the transformations occurring between V1 and the VWFA, we measured (using functional magnetic resonance imaging, fMRI) and perturbed (using transcranial magnetic stimulation) neural responses in several visual areas while subjects read words defined by atypical visual features (Chapter 2). We show that VWFA responses are invariant to the visual features that define word stimuli, and we show how flexible neural circuitry accounts for these abstract representations. While these studies contribute to understanding the VWFA's inputs, the inner organization of the VWFA remains unexplored. We describe experiments that use fMRI and electrocorticography (ECoG) in the human brain to show that the VWFA is sensitive to visual field position, and that together with a homologous right-hemisphere region, its inner organization encompasses a retinotopic map (Chapter 3). Information about abstract word forms is in turn transferred from the VWFA to language areas of the brain. This transfer occurs via large white-matter bundles that can be measured with diffusion imaging (DTI). We compare data from a severely dyslexic individual to a group of control subjects and show that the individual's deficits are due to a missing arcuate fasciculus, one of the major pathways important for reading and language (Chapter 4). This set of experiments ties together several fields of neuroscientific inquiry, including early visual processing, complex visual object representations, and language. Ultimately, if we are to understand how spots of light are transformed into sounds and meaning, we must unravel the smaller transformations that occur within all these components of the reading circuitry.
- 2011Brittany E. Burrows.The amount of information available to the retina far exceeds the processing capacity of the visual system. Visual attention provides a means by which we can make use of the information available with optimal efficiency, allowing us to selectively process objects that are most likely to help us achieve our behavioral goals while filtering out others. Decades of research have revealed that visual representations of objects aligned with the locus of attention are enhanced, resulting in perceptual benefits. The attentional modulation of visual cortical responses, however, has been almost exclusively characterized within the context of volitionally deployed, top-down attention. Although the behavioral correlates of involuntarily deployed, bottom-up attention are well known, the underlying neural mechanism and its relationship to top-down attention are not. In Chapters 2 and 3 of this thesis, I describe experiments that investigate the neural correlates and mechanisms of bottom-up attention. In order to examine the neural correlates of bottom-up attention, we measured responses of single neurons in area V4 to "popout" stimuli, which differ uniformly from surrounding items and draw attention in a bottom-up manner, and compared them to responses to "conjunction" stimuli, which are composed of a combination of surrounding features and require top-down selection. We found that V4 responses are modulated by popout stimuli. This selectivity was more robust when larger numbers of surrounding items and multiple features were included in the display, and it was absent when only a few items were presented immediately outside the receptive field (RF). We next examined the relationship between bottom-up and top-down attention by measuring responses to these same stimuli while top-down attention was directed to locations distant from the RF. We found that popout selectivity was eliminated, indicating that the salience of popout stimuli is not sufficient to drive selection by V4 neurons under these conditions. These results demonstrate that neurons in feature-selective cortex are influenced by bottom-up attention, but that this influence is limited by top-down attention. Whether the source of the signal initiating attentional deployment is top-down or bottom-up, our gaze is typically aligned with the locus of our attention, making use of the high density of photoreceptors at the fovea of the retina. As we move our eyes around a visual scene to briefly fixate objects for further processing, we do not perceive the explosive onset of motion between each fixation that is created by these eye movements, nor do we perceive a series of individual snapshots from each fixation. Instead, we have a seamless visual experience of our surroundings. This perception of continuity across eye movements is crucial to efficient behavior, and yet the neural mechanisms that support a continuous visual experience are not well understood. In Chapter 4 of this thesis, I describe an experiment that investigates the neural representations of perceptual continuity during saccadic eye movements. In order to examine whether V4 neurons are involved in creating a continuous perceptual experience, we measured the responses of V4 neurons to probe stimuli presented during the preparation of saccadic eye movements to targets distant from the RF. We observed that the responses of area V4 neurons to probe stimuli depended on the similarity between the neuronal preference and the target of a saccade. Specifically, the suppression of V4 responses normally present during the preparation of saccades to targets outside of a neuron's RF was absent when the features of the target were congruent with the preference of the recorded neuron. This target-dependent modulation resulted in a substantial effect of the target match/non-match manipulation on neuronal selectivity. The results are consistent with a computational model in which saccade preparation automatically results in a global target-dependent modulation of visual cortical signals. We suggest that this modulation may contribute to the continuity of perception across saccadic eye movements. The results of this thesis demonstrate that V4 neurons are selective for stimuli that draw bottom-up attention. Surprisingly, this selectivity depends on the availability of top-down attentional resources, suggesting that these two distinct varieties of visual attention rely, at least in part, on a common mechanism. Additionally, this thesis provides evidence that V4 neurons contribute to a seamless perceptual experience by maintaining important visual information transaccadically.
- 1949-J.H. Prince.
- 2006 Ovid[edited by] Robert H. Duckman.Development of the visual system / T. Rowan Candy -- Visual acuity in the young child / Robert H. Duckman -- Contrast sensitivity function / Karl Citek -- Refractive error / David E. FitzGerald -- Development of eye movements in infants / Jordan R. Pola -- Development of accommodation in human infants / Mark Rosenfield -- Development of binocular vision / Robert H. Duckman and Jojo W. Du -- Development of color vision in infants / Israel Abramov and James Gordon -- The pediatric case history / Robert H. Duckman and Jessica Yang -- Infant, toddler, and children's visual acuity--practical aspects / Robert H. Duckman -- Assessment of ocular health / Shoshana Bell-Craig and Robert H. Duckman -- Abnormalities of the anterior segment / Pamela Hooker -- Abnormalities of the posterior segment / Pamela Hooker -- Quantification of refractive error / Amelia G. Bartolone and Daniella Rutner -- Pediatric and adolescent contact lens correction / David P. Libassi and Ralph E. Gundel -- Evaluation of ocular motor function / Richard London -- Clinical tests of fusion and stereopsis / M.H. Esther Han and Robert H. Duckman -- Evaluation of accommodation / Ida Chung-Lock -- Pediatric color vision testing / Jay M. Cohen -- Prescribing lenses for the pediatric patient / Robert H. Duckman -- Options in strabismus / Valerie M. Kattouf -- Options in amblyopia / Valerie M. Kattouf -- Vision therapy for the very young patient / Carl Gruning, David E. FitzGerald, and Robert H. Duckman -- Development of a normal child / Robert H. Duckman and David A. Maze -- Visual concerns in the child with special needs / Barry Kran, Stacy Lyons, and Melissa Suckow.
- 2014 SpringerNigel W. Daw.Introduction -- Functional Organization of the Visual System -- Part I: Development of the Visual System -- Development of Visual Capabilities -- Anatomical Development of the Visual System -- Development of Receptive Field Properties -- Part II: Amblyopia and the Effects of Visual Deprivation -- Modifications to the Visual Input that lead to Nervous System changes -- Known Physiological and Anatomical changes from optical and motor deficits -- What is Amblyopia? -- Critical Periods -- Treatment of Amblyopia -- Part III: Mechanisms of Plasticity -- Concepts of Plasticity -- Mechanisms of Plasticity in the Visual Cortex -- Deprivation Myopia and Emmetropization -- Index.
- 2010 Ovideditor-in-chief, Esther K. Chung ; associate editors, Lee Atkinson-McEvoy, Julie A. Boom, Paul S. Matz.Section 1. Visual Diagnoses in the Newborn -- Section 2. General Appearance -- Section 3. Head -- Section 4. Eyes -- Section 5. Ears -- Section 6. Nose -- Section 7. Mouth -- Section 8. Neck -- Section 9. Chest -- Section 10. Abdomen -- Section 11. Back -- Section 12. Extremities -- Section 13. Genital and Perineal Region -- Section 14. Perianal Area and Buttocks -- Section 15. Skin.
- 2015 Ovideditor in chief, Esther K. Chung, MD, MPH, Professor, Department of Pediatrics, Sidney Kimmel Medical College of Thomas Jefferson University, Jefferson Pediatrics/Nemours-Philadelphia, Philadelphia, Pennsylvania, Alfred I. duPont Hospital for Children, Wilmington, Delaware, ; associate editors, Lee R. Atkinson-McEvoy, MD, Clinical Professor of Pediatrics, Director of UCSF Pediatric Primary Care Clinic, Associate Chief General Pediatrics, Associate Residency Program Director, Department of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, California, Naline L. Lai, MD, Primary Care Attending Physician, The Children's Hospital of Philadelphia Care Network-Newtown, Newtown, Pennsylvania, Department of Pediatrics, St. Mary Mary Medical Center, Langhorne, Pennsylvania, Department of Pediatrics, Doylestown Hospital, Doylestown, Pennsylvania, Michelle Terry, MD, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
- 2006 Ovideditor-in-chief, Esther K. Chung ; associate editors, Julie A. Boom, George A. Datto, III, Paul S. Matz.General appearance / Evan J. Weiner -- Scalp swellings in newborns / Hans B. Kersten -- Newborn physical findings: facial lesions / Laura E. Smals -- Abnormal head shape / Laura E. Smals -- Hair loss / George A. Datto, III -- White specks in the hair / Hans B. Kersten -- Lumps on the face / Kelly R. Leite and Kathleen Cronan -- Red eye / Parul B. Patel and Steven M. Selbst -- Swelling of/around the eye / English D. Willis and Terri L. Young -- Discoloration of/around the eye / Maryellen E. Gusic and Dean John Bonsall -- Pupil, iris, and lens abnormalities / Renee M. Turchi and Esther K. Chung -- Misalignment of the eyes / Maryellen E. Gusic and Dean John Bonsall -- Abnormalities in ear shape and position / Charles A. Pohl -- Ear swelling / Kathleen Cronan -- Ear pits and tags / Renee M. Turchi and David E. Tunkel -- Ear canal findings / Lee R. Atkinson-McEvoy and Esther K. Chung -- Tympanic membrane abnormalities / Charles A. Pohl -- Nasal bridge swelling / Shoshana Melman -- Nasal swelling, discharge, and crusting / Shareen F. Kelly -- Mouth sores and patches / Robert L. Bonner, Jr -- Focal gum lesions / Nancy D. Spector -- Discoloration of the teeth / Harold V. Salvati -- Oral clefts and other variants / Cynthia Collier Warren and Paul S. Matz -- Tongue discoloration and surface changes / Christopher O'Hara -- Swellings within the mouth / Nancy D. Spector -- Throat redness / Robert L. Bonner, Jr -- Neck masses and swelling / Serena Yang -- Abnormal chest shape / Amy Renwick -- Breast swelling and enlargement / Heather E. Needham and Mariam R. Chacko -- Chest lumps / George A. Datto, III -- Abdominal midline bulge / Aviva L. Katz -- Enlarged/distended abdomen / Vani Gopalareddy and Devendra I. Mehta -- Curvature of the back / Shareen F. Kelly -- Midline back pits, skin tags, hair tufts, and other lesions / Paul S. Matz -- Nail abnormalities / Denise W. Metry and Brandi M. Kenner -- Arm displacement / Jeoffrey K. Wolens -- Arm swelling / Teresia O'Connor -- Hand swelling / Serena Yang -- Finger abnormalities / Robert L. Zarr -- Fingertip swelling / Julieana Nichols -- Newborn physical findings: lower extremity abnormalities / Serena Yang -- Leg asymmetry / Jeoffrey K. Wolens -- Leg bowing and knock knees / Sujata R. Tipnis -- Intoeing / Sujata R. Tipnis -- Knee swelling / Julie A. Boom -- Foot deformities / Sujata R. Tipnis -- Foot swelling / Aida Zarina Khanum -- Foot rashes and lumps / Denise W. Metry and Brandi M. Kenner -- Female genitalia, variations / Collette C. Mull -- Penile abnormalities / T. Ernesto Figueroa and Ilia Zeltser -- Penile swelling / T. Ernesto Figueroa and Ilia Zeltser -- Perineal red rashes / Kathleen Cronan -- Perineal sores and lesions / Allan R. De Jong -- Vulvar swelling and masses / Allan R. De Jong -- Scrotal swelling / William R. Graessle -- Perianal and buttock swelling / Michael J. Wilsey, Jr and Karina Irizarry -- Perianal and buttock redness / Robert L. Zarr -- Imperforate anus / Julieana Nichols -- Newborn physical findings: skin abnormalities / Denise A. Salerno -- Facial rashes / Gary A. Emmett -- Diffuse red rashes / Susanne Kost -- Red patches and swellings / Nicholas B. Slamon -- Linear red rashes / Erin Preston -- Focal red bumps / George A. Datto, III -- Raised red rashes / Kathleen Cronan -- Vesicular rashes / Shirley P. Klein -- Nonblanching rashes / William R. Graessle -- Scaly rashes / Esther K. Chung -- Fine, bumpy rashes / George A. Datto, III -- Hypopigmented rashes / George A. Datto, III -- Hyperpigmented rashes / George A. Datto, III -- Bullous rashes / Angela Allevi.
- 2010 ClinicalKeyFelasfa M. Wodajo, Francis H. Gannon, Mark D. Murphey.This book uses a pattern-recognition approach to help you diagnose challenging musculoskeletal tumors with confidence. With an easy-to-use format, it is the only resource that correlates histology studies and imaging studies. By comparing images these superb-quality, large-scale images, you can master pattern recognition for the 30 most important musculoskeletal tumors and make informed, effective, and rapid decisions on diagnosis and treatment.
- 2014 SpringerMaureen D. Mayes, editor.1. Brief Overview of Scleroderma: Localized Scleroderma and Systemic Sclerosis (SSc) / Maureen D. Mayes -- 2. Localized Scleroderma / Carolyn A. Bangert, Andrew Kim, and Heidi Jacobe -- 3. Skin Manifestations and Musculoskeletal Disease in SSc / Janet Pope and Maureen D. Mayes -- 4. Nailfold Capillaroscopy / Michael Hughes and Ariane L. Herrick -- 5. Ischemic Digital Ulcers / Fredrick M. Wigley -- 6. Lung Involvement in Systemic Sclerosis / John T. Huggins, James G. Ravenel, and Richard M. Silver -- 7. Gastrointestinal Involvement in Systemic Sclerosis / Dinesh Khanna, Jason Baker, Philip J. Clements, and Christopher P. Denton -- 8. Calcinosis Cutis in Systemic Sclerosis / Gloria A. Salazar and Maureen D. Mayes -- 9. Systemic Sclerosis Mimics / Gloria A. Salazar, Virginia D. Steen, and Maureen D. Mayes.
- pt. 1-2. ScienceDirectFulltext (pt. 2) ScienceDirectedited by S. Martinez-Conde [et al.].Pt. 1. Fundamentals of vision: low and mid-level processes in perception -- Pt. 2. Fundamentals of awareness: multi-sensory integration and high-order perception.
- 2007 Springeredited by Joyce Tombran-Tink, Colin J. Barnstable, Joseph F. Rizzo III.1 Retinal prosthetic devices: the needs and future potential -- 2 Spatial-, temporal-, and contract-resolutions obtainable with retina implants -- 3 How to restore reading with visual prostheses -- 4 Subretinal artificial silicon retinal microchip implantation with retinitis pigmentosa -- 5 Development of an intraocular retinal prosthesis to benefit the visually impaired -- 6 Development of a visual prosthesis: a review of the field and an overview of the Boston Retinal Implant Project -- 7 The Minimally Invasive Retina Implant Project -- 8 A retinal implant system based on flexible polymer microelectrode array for electrical stimulation -- 9 Electrode architecture: meeting the challenge of the retina-electrode interface -- 10 Circuit designs that model the properties of the outer and inner retina -- 11 Visual cortex and extraocular retinal stimulation with surface electrode arrays -- 12 Glaucoma drainage devices: advances in design and surgical techniques -- 13 The efficacy and safety of glaucoma drainage devices -- 14 Pellucid marginal corneal degeneration -- 15 Artisan toric lens implantation for correction of postkeratoplasty astigmatism -- 16 Phakic intraocular lenses for the treatment of high myopia -- 17 A telescopic prosthetic device for patients with end-stage AMD -- 18 The use of intracorneal ring segments for keratoconus.
- 2008 Springeredited by Joyce Tombran-Tink, Colin J. Barnstable.An organ of exquisite perfection / George Ayoub -- Development of the Foveal specialization / Keely M. Bumsted O'Brien -- An update on the regulation of rod photoreceptor development / Edward M. Levine and Sabine Fuhrmann -- Photoreceptor-RPE interactions : physiology and molecular mechanisms / Silvia C. Finnemann and Yongen Chang -- Molecular biology of IRBP and its role in the visual cycle / Diane E. Borst, Jeffrey H. Boatright, and John M. Nickerson -- Regulation of photoresponses by phosphorylation / Alecia K. Gross, Qiong Wang, and Theodore G. Wensel -- The cGMP signaling pathway in retinal photoreceptors and the central role of photoreceptor phosphodiesterase (PDE6) / Rick H. Cote -- Rhodopsin structure, function, and involvement in retinitis pigmentosa / Scott Gleim and John Hwa -- Multiple signaling pathways govern calcium homeostasis in photoreceptor inner segments / Tamas Szikra and David Krizaj -- The transduction channels of rod and cone photoreceptors / Dimitri Tränkner -- Rhodopsins in Drosophila color vision / David Jukam, Preet Lidder, and Claude Desplan -- INAD signaling complex of Drosophila photoreceptors / Armin Huber and Nina E. Meyer -- Visual signal processing in the inner retina / Botir T. Sagdullaev, Tomomi Ichinose, Erika D. Eggers, and Peter D. Lukasiewicz -- Human clone spectral sensitivities and color vision deficiencies / Andrew Stockman and Lindsay T. Sharpe -- Luminous efficiency functions / Lindsay T. Sharpe and Andrew Stockman -- Cone pigments and vision in the mouse / Gerald H. Jacobs -- Multifocal oscillatory potentials of the human retina / Anne Kurtenbach and Herbert Jägle -- The aging of the retina / Caren Bellmann and José A. Sahel -- Aging of the retinal pigment epithelium / Michael E. Boulton -- Visual transduction and age-related changes in lipofuscin / Małgorzata Różanowski and Bartosz Różanowski -- A nonspecific system provides nonphotic information for the biological clock / Marian H. Lewandowski -- The circadian clock : physiology, genes, and disease / Michael C. Antle.
- 2006 SpringerJoachim Weickert, Hans Hagen (editors).
- 2008 SpringerLars Linsen, Hans Hagen, Bernd Hamann, editors.
- 2012 Springer Protocolsedited by Emilio Badoer.Multiple immunohistochemical labelling of peripheral neurons / Ian L. Gibbins -- Combined in situ hybridization and immunohistochemistry in rat brain tissue using digoxigenin-labeled riboprobes / Natasha N. Kumar, Belinda R. Bowman, and Ann K. Goodchild -- In situ hybridization within the CNS tissue : combining in situ hybridization with immunofluorescence / Dominic Bastien and Steve Lacroix -- Visualizing GABA[subscriptβ] receptor internalization and intracellular trafficking / Paola Ramoino [and others] -- Using total internal reflection fluorescence microscopy (TIRFM) to visualise insulin action / James G. Burchfield, Jamie A. Lopez, and William E. Hughes -- Live-cell quantification of mitochondrial functional parameters / Marco Nooteboom [and others] -- Functional imaging using two-photon microscopy in living tissue / Ivo Vanzetta [and others] -- Calcium imaging techniques in vitro to explore the role of dendrites in signaling physiological action potential patterns / Audrey Bonnan, Benjamin Grewe, and Andreas Frick -- Juxtacellular labeling in combination with other histological techniques to determine phenotype of physiologically identified neurons / Ruth L. Stornetta -- Visualization of activated neurons involved in endocrine and dietary pathways using GFP-expressing mice / Rim Hassouna [and others] -- Use and visualization of neuroanatomical viral transneuronal tracers / J. Patrick Card and Lynn W. Enquist -- Visualisation of thermal changes in freely moving animals / Daniel M.L. Vianna and Pascal Carrive -- Perfusion magnetic resonance imaging quantification in the brain / Fernando Calamante.
- Ben Fry.Provides information on the methods of visualizing data on the Web, along with example projects and code.
- 2009 SpringerDorian McGavern, Michael Dustin, editors.Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses / Andrew Bullen, Rachel S. Friedman, and Matthew F. Krummel -- Visualizing intermolecular interactions in T cells / Nicholas R.J. Gascoigne ... [et al.] -- Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse / Michael L. Dustin -- T cell migration dynamics within lymph nodes during steady state: an overview of extracellular and intracellular factors influencing the basal intranodal T cell motility / Tim Worbs and Reinhold Forster -- Chemoattractant receptor signaling and its role in lymphocyte motility and trafficking / John H. Kehrl, Il-Young Hwang, and Chung Park -- New insights into leukocyte recruitment by intravital microscopy / Alexander Zarbock and Klaus Ley -- Visualizing the molecular and cellular events underlying the initiation of B-cell activation / Naomi E. Harwood and Facundo D. Batista -- Tracking the dynamics of Salmonella specific T cell responses / James J. Moon and Stephen J. McSorley -- Imaging Listeria monocytogenes infection in vivo / Vjollca Konjufca and Mark J. Miller -- Inflammation on the mind: visualizing immunity in the central nervous system / Silvia S. Kang and Dorian B. McGavern -- Multiphoton imaging of cytotoxic T lymphocyte-mediated antitumor immune responses / Alexandre Boissonnas ... [et al.].Also available: Print – 2009
- 2010Li Ling.The mammalian nervous system consists of billions of neurons arranged into complicated networks (neuronal circuits) that mediate all aspects of brain function and behavior. A fundamental goal of neuroscience is to describe the structure of neural circuits at the level of single cells and to understand how this structure enables information acquisition, processing, storage, and ultimately the control of behavior. Over the past hundred years, the cumulative efforts of many individuals have led to the development of a wide array of neuronal labeling tools. First, in this thesis, with the ultimate goal of further expanding genetically coded labeling tools to visualize the presynaptic distribution in single neurons within the mouse brain in vivo, I developed a new genetic synaptic labeling method and used it to analyze the spatial patterning of synapses in developing and mature cerebellar granule. Second, taking the advantage of the MADM system that allows gene knockout in single cells and simultaneously labeling the cells for morphology characterization, I also utilized MADM to study the function of the Rai1 gene, heterozygosity of which results in Smith-Magenis Syndrome in human.
- 2016 ScienceDirectedited by Grigory S. Filonov and Samie R. Jaffrey.Chapter One. RNA Imaging with Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) / J.R. Moffitt, X. Zhuang -- Chapter Two. Imaging Single mRNA Dynamics in Live Neurons and Brains / H.C. Moon, H.Y. Park -- Chapter Three. Monitoring of RNA Dynamics in Living Cells Using PUM-HD and Fluorescent Protein Reconstitution Technique / H. Yoshimura, T. Ozawa -- Chapter Four. Applications of Hairpin DNA-Functionalized Gold Nanoparticles for Imaging mRNA in Living Cells / S.R. Jackson, A.C. Wong, A.R. Travis, I.E. Catrina, D.P. Bratu, D.W. Wright, A. Jayagopal -- Chapter Five. In Vivo RNA Visualization in Plants Using MS2 Tagging / E.J. Peña, M. Heinlein -- Chapter Six. TRICK: A Single-Molecule Method for Imaging the First Round of Translation in Living Cells and Animals / J.M. Halstead, J.H. Wilbertz, F. Wippich, T. Lionnet, A. Ephrussi, J.A. Chao -- Chapter Seven. Fluctuation Analysis: Dissecting Transcriptional Kinetics with Signal Theory / A. Coulon, D.R. Larson -- Chapter Eight. IMAGEtags: Quantifying mRNA Transcription in Real Time with Multiaptamer Reporters / J. Ray, I. Shin, M. Ilgu, L. Bendickson, V. Gupta, G.A. Kraus, M. Nilsen-Hamilton -- Chapter Nine. A Method for Expressing and Imaging Abundant, Stable, Circular RNAs In Vivo Using tRNA Splicing / C.A. Schmidt, J.J. Noto, G.S. Filonov, A.G. Matera -- Chapter Ten. RNA-ID, a Powerful Tool for Identifying and Characterizing Regulatory Sequences / C.E. Brule, K.M. Dean, E.J. Grayhack -- Chapter Eleven. Fluorescent Protein-Based Quantification of Alternative Splicing of a Target Cassette Exon in Mammalian Cells / N.G. Gurskaya, D.B. Staroverov, K.A. Lukyanov -- Chapter Twelve. IRAS: High-Throughput Identification of Novel Alternative Splicing Regulators / S. Zheng -- Chapter Thirteen. Analysis of Nonsense-Mediated mRNA Decay at the Single-Cell Level Using Two Fluorescent Proteins / N.G. Gurskaya, A.P. Pereverzev, D.B. Staroverov, N.M. Markina, K.A. Lukyanov -- Chapter Fourteen. Developing Fluorogenic Riboswitches for Imaging Metabolite Concentration Dynamics in Bacterial Cells / J.L. Litke, M. You, S.R. Jaffrey.
- Also available: Print – 1995
- 2008 Kargervolume editor, Carsten H. Meyer.A vitrectomy is done, when the vitreous is gone! : a tribute to prof. Peter Kroll / C.H. Meyer -- To see the invisible : the quest of imaging vitreous / J. Sebag -- Historical aspects and evolution of the application of vital dyes in vitreoretinal surgery and chromovitrectomy / E.B. Rodrigues ... [et al.] -- Three simple approaches to visualize the transparent vitreous cortex during vitreoretinal surgery / J.C. Schmidt ... [et al.] -- Safety parameters for indocyanine green in vitreoretinal surgery / S. Grisanti ... [et al.] -- Toxicity of indocyanine green in vitreoretinal surgery / A. Gandorfer, C. Haritoglou, A. Kampik -- Biomechanical changes of the internal limiting membrane after indocyanine green staining / G. Wollensak -- Current concepts of trypan blue in chromovitrectomy / M.E. Farah ... [et al.] -- Trityl dyes patent blue V and brilliant blue G : clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier / S. Mennel ... [et al.] -- Brilliant blue in vitreoretinal surgery / H. Enaida, T. Ishibashi -- Vital staining and retinal detachment surgery / T.L. Jackson -- An experimental approach towards novel dyes for intraocular surgery / C. Haritoglou ... [et al.] -- Experimental evaluation of microplasmin : an alternative to vital dyes / A. Gandorfer.Also available: Print – 2008
- 2012 KargerRichard D. Semba.Vitamin A deficiency in nineteenth century naval medicine -- Paris in the time of Francois Magendie -- Deprivation provides a laboratory -- Free but not equal -- The long, rocky road to understanding vitamins -- Milk, butter, and early steps in human trials -- Rise of the 'anti-infective vitamin' -- Vitamin A deficiency in Europe's former colonies -- Saving the children : rescue missions against strong undertow -- Night blindness among Black troops and White troops in the U.S. Civil War.
- 2008 CRCnetBASERonald Eitenmiller, Lin Ye, W.O. Landen, Jr.Vitamin A and carotenoids -- Vitamin D -- Vitamin E: tocopherols and tocotrienols -- Vitamin K -- Ascorbic acid: vitamin C -- Thiamin -- Riboflavin -- Niacin -- Vitamin B6 -- Folate and Folic acid -- Vitamin B12 -- Biotin -- Pantothenic acid -- Multi-analyte methods for analysis of the fat- and water-soluble vitamins.
- 2014 CRCnetBASEedited by Krishnamurti Dakshinamurti and Shyamala Dakshinamurti.Chapter 1. Retinoic acid : metabolism, developmental functions, and evolution / Joô E. Carvalho and Michael Schubert -- chapter 2. Serum retinol-binding protein, obesity, and insulin resistance / Pangala V. Bhat and Daniel-Constantin Manolescu -- chapter 3. Retinoic acid and immunity / Yoshishige Miyabe, Chie Miyabe, and Toshihiro Nanki -- chapter 4. Vitamin D3 Up-regulated Protein 1 (VDUP1) and the immune system / Hyun Woo Suh ... [et al.] -- chapter 5. Rapid pre-genomic responses of vitamin D / Tremaine M. Sterling ... [et al.] -- chapter 6. The role of vitamin D in infectious processes / Russell W. Chesney -- chapter 7. Vitamin D, vitamin D binding protein, and cardiovascular disease / Diane Berry and Elina Hyppn̲en -- chapter 8. Vitamins E and C : effects on matrix components in the vascular system / Jean-Marc Zingg, Mohsen Meydani, and Angelo Azzi -- chapter 9. Vitamin K and vascular calcification / Chandrasekar Palaniswamy ... [et al.] -- chapter 10. Therapeutic effects of pyridoxamine and benfotiamine / Shyamala Dakshinamurti and Krishnamurti Dakshinamurti -- chapter 11. Multifaceted therapeutic potential of vitamin B6 / Shyamala Dakshinamurti and Krishnamurti Dakshinamurti -- chapter 12. Non-prosthetic group functions of biotin / Krishnamurti Dakshinamurti -- chapter 13. Mechanisms of gene transcriptional regulation through biotin and biotin-binding proteins in mammals / Janos Zempleni ... [et al.] -- chapter 14. Folate receptor-mediated therapeutics : folate receptor- mediated particle systems for drug and gene delivery in cancer therapy / Yoshie Maitani -- chapter 15. Vitamin B12 derivatives and preferential targeting of tumors / Evelyne Furger and Eliane Fischer -- chapter 16. Ascorbic acid : binding proteins and pathophysiology / Fryad Rahman and Michel Fontš.
- 2016 SpringerVin Tangpricha, editor.Young Woman with Vitamin D Deficiency -- Vitamin D Deficiency in Infants -- Vitamin D Deficiency in Cystic Fibrosis -- Vitamin D Deficiency in Anorexia Nervosa -- Vitamin D Deficiency Following Bariatric Surgery -- Vitamin D in Postsurgical Hypoparathyroidism -- Vitamin D in Patients with Hypoparathyroidism/Hypocalcemia -- Vitamin D in Disorders of Phosphorus -- Vitamin D in Disorders of Vitamin D Action: Vitamin D Dependent Rickets Type I -- Vitamin D Deficiency in Chronic Kidney Disease -- Vitamin D in Psoriasis.
- 2010 Springeredited by Michael F. Holick.Vitamin D and health: evolution, biologic functions, and recommended dietary intakes for vitamin D / Michael F. Holick -- Photobiology of vitamin D / Tai C. Chen, Zhiren Lu, and Michael F. Holick -- The functional metabolism and molecular biology of vitamin D action / Lori A. Plum and Hector F. DeLuca -- Metabolism and catabolism of vitamin D, its metabolities and clinically relevant analogs / Glenville Jones -- The molecular biology of the vitamin D receptor / Diane R. Dowd and Paul N. MacDonald -- VDR and RXR subcellular trafficking / Julia Barsony -- Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption and renal calcium transport / Dare Ajibade, Bryan S. Benn, and Sylvia Christakos -- Biological and molecular effects of vitamin D on bone / Martin A. Montecino ... [et al.] -- Biological and molecular effects of vitamin D on the kidney / Adriana S. Dusso and Masanori Tokumoto -- Vitamin D and the parathyroids / Justin Silver and Tally Naveh-Many -- Diversity of vitamin D target genes / Carsten Carlberg -- Extrarenal synthesis of 1,25-dihydroxyvitamin D and its health implications / Daniel D. Bikle -- Vitamin D and the innate immunity / Philip T. Liu, Martin Hewison, and John S. Adams -- Vitamin D and colon cancer / Heide S. Cross and Meinrad Peterlik -- Mechanisms of resistance to vitamin D action in human cancer cells / María Jesús Larriba and Alberto Muñoz -- Vitamin D and the brain: a neuropsychiatric perspective / Louise Harvey ... [et al.] -- Vitamin D modulation of adipocyte function / Michael B. Zemel and Xiaocun Sun -- Determinants of vitamin D intake / Mona S. Calvo and Susan J. Whiting -- 25-hydroxyvitamin D assays and their clinical utility / N. Binkley and G. Lensmeyer -- Health disparities and vitamin D / Douglass Bibuld -- Vitamin D deficiency in Canada / David A. Hanley -- Vitamin D deficiency and its health consequences in Northern Europe / Leif Mosekilde -- Vitamin D deficiency and consequences for the health of people in Mediterranean countries / Jose Manuel Quesada-Gomez and Manuel Díaz-Curiel -- Vitamin D deficiency in the Middle East and its health consequences / Ghada El-Hajj Fuleihan -- Vitamin D deficiency in the Middle East and its health consequences for adults / Samer El-Kaissi and Suphia Sherbeeni -- Vitamin D deficiency and its health consequences in Africa / Ann Prentice ... [et al.] -- Vitamin D deficiency and its health consequences in India / R.K. Marwaha and R. Goswami -- Vitamin D deficiency, rickets, and fluorosis in India / C. V. Harinarayan and Shashank R. Joshi -- Vitamin D in Asia / Tim Green and Bernard Venn -- Vitamin D deficiency and its health consequences in New Zealand / Mark J. Bolland and Ian R. Reid -- Toxicity of vitamin D / Reinhold Vieth -- Vitamin D deficiency in pregnancy and lactation and health consequences / Sarah N. Taylor, Carol L. Wagner, and Bruce W. Hollis -- Vitamin D deficiency in children and its health consequences / Amy D. DiVasta, Kristen K. van der Veen, and Catherine M. Gordon -- Dietary calcium deficiency and rickets / John M. Pettifor, Philip R. Fischer, and Tom D. Thacher -- Vitamin D in fracture prevention and muscle function and fall prevention / Heike Bischoff-Ferrari -- Inherited defects of vitamin D metabolism / Marie B. Demay -- Molecular defects in the vitamin D receptor associated with hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) / Peter J. Malloy and David Feldman -- Receptor-independent vitamin D resistance in subhuman and human primates / John S. Adams ... [et al.] -- 25-hydroxyvitamin D-1α-hydroxylase: studies in mouse models and implications for human disease / David Goltzman -- The health benefits of solar irradiance and vitamin D and the consequences of their deprivation / William B. Grant -- Vitamin D status, solar radiation and cancer prognosis / Johan Moan ... [et al.] -- The epidemiology of vitamin D and cancer risk / Edward Giovannucci -- Vitamin D deficiency and the epidemiology of prostate cancer / Gary G. Schwartz -- Vitamin D for cancer prevention and survival / Edward D. Gorham ... [et al.] -- The anti-cancer effect of vitamin D: what do the randomized trials show? / Joan M. Lappe and Robert P. Heaney -- Sunlight, skin cancer, and vitamin D / Jörg Reichrath -- Vitamin D and the risk of type 1 diabetes / Elina Hyppönen -- Vitamin D and multiple sclerosis / Alberto Ascherio and Kassandra L. Munger -- Vitamin D and type 2 diabetes / Myrto Eliades and Anastassios G. Pittas -- Role of vitamin D for cardiovascular health / Robert Scragg -- Vitamin D, renin, and blood pressure / Yan Chun Li -- Role of vitamin D and vitamin D analogs for bone health and survival in chronic kidney disease / Ishir Bhan, Hector Tamez, and Ravi Thadhani -- Role of vitamin D and ultraviolet radiation in chronic kidney disease / Rolfdieter Krause -- Role of vitamin D in rheumatoid arthritis / Linda A. Merlino -- Vitamin D, respiratory infections, and obstructive airway diseases / Carlos A. Camargo Jr, Adit A. Ginde, and Jonathan M. Mansbach -- Treatment of immunomediated diseases by vitamin D analogs / Luciano Adorini -- Clinical utility of 1,25-dihydroxyvitamin D3 and its analogues for the treatment of psoriasis / Jörg Reichrath and Michael F. Holick -- Affinity alkylating vitamin D analogs as molecular probes and therapeutic agents / Rahul Ray -- Anti-inflammatory activity of calcitriol that contributes to its therapeutic and chemopreventive effects in prostate cancer / Aruna V. Krishnan and David Feldman.Also available: Print – 2010
- Vaccination : a tool for the control of avian influenza : Verona, Italy, 20-22 March, 2007 : proceedings of a joint OIE/FAO/IZSVe conference co-organised with the European Commission — Vertigo : a clinical guide (100)
- Vertigo and balance disorders in children — Vitamin D-- physiology, molecular biology, and clinical applications. 2nd ed. (100)
- Vitamin D and cancer — VU/TEXT (40)
- Harrison's Principles of Internal Medicine
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