BookXiaobo Zhang, editor.
Summary: This book reviews the latest research on the molecules and mechanisms of marine host stress responses to viral infections and tumorigenesis. It offers an overview of the state of the art in the field as well as future directions. Metabolism disorder is a characteristic of tumorigenesis. Since viruses complete their life cycle in host cells, such infections cause metabolic disorders in the host. As such, the mechanisms of virus pathogenesis and tumor progression are similar or even identical. In essence, the role of antiviral molecules is to maintain the metabolic homeostasis of infected host cells, and the antiviral molecules induced by virus infection may play an important role in antitumor pathways, resulting in cancer cell death or restoring the disordered metabolism of cancer cells. The molecules generated during host stress responses to viruses can also contribute to the antitumor mechanisms in humans. However, the relationship between host stress responses to virus infection and tumorigenesis has not been extensively explored. In recent years, studies have shown that marine host stress responses to viral invasion can be good models for exploring human antitumor mechanisms. Stimulating further research in the field, this book offers graduate students and researchers with comprehensive insights into host stress responses to viral invasion and tumor progression. It is also a valuable resource for those working in the pharmaceutical industry interested in drug discovery based on molecules derived from host stress responses to viral infection.
Contents:
Intro; Contents;
Chapter 1: Overview of Virus Infection and Tumorigenesis; 1.1 The Significance of Virus in the Ocean; 1.2 Roles of Bacteriophages in the Extreme Environment; 1.3 Virus Infection and Host Metabolism; 1.3.1 Virus Infection and Host Glucose Metabolism; 1.3.2 Virus Infection and Host Lipid Metabolism; 1.3.3 Virus Infection and Host Nucleic Acid Metabolism; 1.3.4 Virus Infection and Host Vitamin Metabolism; 1.4 Cancer and Metabolism; 1.5 Antiviral Stress Responses of Marine Organisms and Antitumor of Human Being 1.5.1 The Roles of miRNAs Derived from Shrimp Stress Responses to Virus Infection in Human Tumorigenesis1.5.2 Effects of Metabolites from Bacterial Stress Response to Bacteriophage Infection on Tumorigenesis; 1.6 Brief Description of the Book; References;
Chapter 2: Marine Viruses; 2.1 Overview of Marine Viruses; 2.1.1 What Are Marine Viruses?; 2.1.2 Progress of Marine Virology; 2.1.3 Progress of Deep-Sea Virology; 2.2 Diversity and Abundance of Marine Viruses; 2.2.1 Abundance of Marine Viruses; 2.2.2 Marine Virus Taxonomy; 2.2.3 Diversity of Deep-Sea Viruses 2.3 The Interactions Between Marine Viruses and Their Hosts2.3.1 The Influence of Marine Phage-Mediated Lysis of Their Hosts on Microbial Community Structure; 2.3.2 The Effects of Marine Phages on the Hosts' Diversity and Metabolism by Lysogeny; 2.3.3 Benefits of Marine Phage on Its Hosts; 2.4 The Roles of Marine Viruses in Global Ecosystems and Climate Changes; 2.4.1 The Roles of Marine Viruses in Global Nutrient and Biogeochemical Cycles; 2.4.2 The Roles of Marine Viruses in Global Climate Changes; 2.5 Summary; References;
Chapter 3: Marine Invertebrate Stress Responses to Virus Infection 3.1 Different Kinds of Stress Responses of Marine Invertebrates3.1.1 The Process of Stress Response; 3.1.2 The Proteins Involved in Stress Response; 3.1.3 Marine Invertebrates; 3.1.4 The Types of Stress Responses in Marine Invertebrates; 3.1.5 The Relationship Between Innate Immunity and Stress Responses in Invertebrates; 3.1.6 Diseases and Stress Responses of Marine Invertebrates; 3.2 Stress Responses of Arthropods; 3.2.1 Stress Responses of Shrimp; Humoral Responses; Crab; Chemicals; Salinity; Unsaturated Fatty Acid; Heavy Metals; Temperature; Physiological Damage; Virus 3.3 Response of Mollusca to Pathogen Invasion3.3.1 Overview of Marine Molluscs; 3.3.2 Stress Response of Molluscs to Pathogen Infection; 3.4 Stress Response of Echinodermata to Pathogen Infection; 3.4.1 Classification and Distribution of Marine Echinoderms; 3.4.2 Diseases and Pathogens of Marine Echinoderms; 3.4.3 Echinoderm Immune Responses to Pathogens; 3.5 Stress Response of Other Marine Invertebrates; 3.6 Summary; References;
Chapter 4: The Roles of MicroRNAs in Antiviral Immunity of Marine Invertebrates; 4.1 The Immune System of Marine Invertebrates