Bookedited by Satya P. Gupta.
Summary: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
Contents:
Fundamentals of viruses and their proteases / Anjana Sharma, Satya P. Gupta
Design and development of some viral protease inhibitors by QSAR and molecular modeling studies / Noha A. Saleh, Hanan Elhaes, Medhat Ibrahim
Advances in studies on adenovirus proteases / Satya P. Gupta, Basheerulla Shaik, Yenamandra S. Prabhakar
Alphavirus nonstructural proteases and their inhibitors / Akalabya Bissoyi, Subrat K. Pattanayak, Arindam Bit, Ashish Patel, Abhishek K. Singh, Sudhanshu S. Behera, Debabrata Satpathy
Structure and function of aplhavirus proteases / Shailly Tomar, Megha Aggarwal
Flavivirus protease / Shailly Tomar, Rajat Mudgal, Benazir Fatma
Flavivirus NS2B/NS3 protease / Zhong Li, Jing Zhang, Hongmin Li
Design and development of HCV NS5B polymerase inhibitors / Debasis Das
Studies on HIV-1 protease and its inhibitors / Sonal Dubey
Studies on picornaviral proteases and their inhibitors / Vaishal M. Patil, Satya P. Gupta
Structural insight into viral 3C-like protease inhibitors / Nilanjan Adhikari, Sandip K. Baidya, Achintya Saha, Tarun Jha
Herpesvirus proteases / Kriti Kashyap, Rita Kakkar
Design and development of inhibitors of herpes viral proteases and their SAR and QSAR / Dimitra Hadjipavlou-Litina, Satya Gupta
Delicate dance in treating hepatitis c infections and overcoming resistance / Dolly A. Parasrampuria.