Bookeditor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon, Edward Giovannucci, David Goltzman, Martin Hewison.
Summary: "Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description.
Contents:
Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d
Evolutionary biology: mysteries of vitamin D in fish
Evolution of human skin color and vitamin D
Photobiology of vitamin D
The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases)
CYP24A1: structure, function, and physiological role
The vitamin D binding protein DBP
Regulation of renal and extra-renal 1[alpha]-hydroxylase
Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells
Diverse mechanisms of transcriptional regulation by the vitamin D receptor
Structural basis for ligand activity in VDR
Ligand independent actions of vitamin D receptor
Vitamin D and chromatin
Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR
Vitamin D and microRNAs
Vitamin D sterol/VDR conformational dynamics and nongenomic actions
Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function
Osteoclastogenesis and vitamin D
Vitamin D activities in osteocytes
Regulation of intestinal calcium and phosphate absorption
Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6
Calcium homeostasis and eggshell biomineralization in female chicken
Mineralization in mammals
Cartilage
Vitamin D and bone: an integrated approach
Section IV. Extra-skeletal targets. Vitamin D and the kidney
Vitamin D and the parathyroids
The calcium-sensing receptor and vitamin d
Vitamin D in dentoalveolar and oral health
The role of vitamin D and its receptor in hair follicle biology
Vitamin D, calcium and the epidermis
Vitamin D and the cardiovascular system
Vitamin D brain development and function
Vitamin D, VDR and adipose tissue: focus on cellular mechanisms
Vitamin D and skeletal muscle
Understanding vitamin D from mouse knockout models
Section V. Human physiology. Pharmacology and pharmacokinetics
Vitamin D role in the calcium and phosphorus economies
Fetus, neonate and infant
Consequences of perinatal vitamin D deficiency on later bone health
Adolescence and acquisition of peak bone mass
Pregnancy, lactation, and post-weaning recovery
Role in reproductive biology and reproductive dysfunction in women
Vitamin d, reproductive biology, and dysfunction in men
Vitamin D and the renin-angiotensin system
Parathyroid hormone, parathyroid hormone-related protein, and calcitonin
FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity
Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease
Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology
Mass spectrometry assays of vitamin D metabolites
Free vitamin d: concepts, assays, outcomes and prospects
25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation
Bone histomorphometry
Radiology of rickets and osteomalcia
High-resolution imaging techniques for bone quality assessment
The role of vitamin D in orthopedic surgery
The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position
The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position
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Books: General Collection (Downstairs)
RC648 .V83 2018
1