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  • Methodology for Eliciting High-Priority Clinical Decision Support Targets -- Oncology Results -- Orthopedics Results -- Pediatrics Results -- Percutaneous Coronary Intervention Panel Results -- Discussion and Recommendations - Appendix A: Oncology Panel Materials - Appendix B: Orthopedics Panel Materials - Appendix C: Pediatrics Panel Materials - Appendix D: Percutaneous Coronary Intervention Panelist Materials.
  • Biotherapeutics have regained their reputation as drug candidates in the drug market due to their remarkable specificity; however, the broader clinical use of biotherapeutics is often challenged by poor pharmacological properties. Therefore, there is enormous interest in developing peptidomimetics as alternative therapeutic options. Inspired by the first successful example of peptide-based antivirals, Fuzeon®, similar strategies to develop antivirals have been applied to many other viruses that share class I fusion protein-mediated viral fusion. Using human Respiratory Syncytial Virus (hRSV) as a model system, the second chapter of this dissertation demonstrates our successful effort to develop a protein-based assay using a 5-Helix Bundle (5HB) fluorescence polarization (FP) as a screening platform for hRSV fusion inhibitors. The remaining chapters in this thesis all utilize the 5HB-based FP assay to evaluate the potential of short peptides and their peptoid-based peptidomimetics as antivirals to control hRSV infections. The third chapter proposes that NMEGylation, an alternative to PEGylation that uses a covalent attachment of an oligo-N-methoxyethylglycine (NMEG) chain, may enhance the bioavailability of short therapeutic peptides. The incorporation of optimized numbers of NMEG monomers along with a glycine linker increases the solubility and serum stability greatly, suggesting that NMEGylation may open a new opportunity to use peptoids as modifiers of therapeutically attractive peptides and proteins. The fourth chapter demonstrates how our novel approach combining alanine, proline, and sarcosine scans can be useful to determine peptoid-replaceable peptide residues and further proves the usefulness of the combined scan strategy using the C20 peptide as a parent peptide. Furthermore, two different methods to promote the [Alpha]-helical conformation of C20 analogues by structurally constraining the parent C20 peptide using "hydrocarbon-stapling" or "clicking" are described. We report a constrained C20 analogue with improved binding affinity, and discuss our structural investigations of the constrained C20 analogues using CD spectroscopy. The studies in the fifth chapter show that phage display can be used for identifying novel hRSV entry inhibitors that are not derived from the original sequence of the hRSV fusion protein F like the peptides described in chapters 2, 3, and 4. We report two 12-mer peptides with a low micromolar binding affinity to the 5HB, and ongoing efforts are aimed towards better understanding the interaction of the 12-mer peptides with the 5HB by co-crystallizing the peptides and 5HB. Finally, the dissertation concludes with a sixth chapter that summarizes the current status of each research chapter. In addition, future prospects, new directions, and potential applications of the findings in this dissertation are presented in this chapter.
  • This dissertation describes a general method for identifying and roughly quantifying the metabolites that are produced by symbiotic dinoflagellates and transferred to cnidarian hosts. I developed a system of rapid filtration and gas chromatography-mass spectrometry (GC-MS) to identify these compounds in the anemone tissue and dinoflagellates separately. I used 13C-sodium bicarbonate to label compounds produced from newly-fixed carbon; the principal compound detected in the animal was glucose. I developed a way to visualize these and other large GC-MS datasets using open-source software. I also built tools for analyzing Ultra-High-Throughput-Sequencing (UHTS) data, and these were useful in the de novo assembly of the Aiptasia pallida transcriptome. One tool I developed compares each read to each other read using a MapReduce framework to merge near-duplicate reads and reduce redundancy in the dataset. In addition, our lab sequenced symbiotic animals and therefore often worked with pools of sequences from multiple organisms. I developed a tool for identifying which transcript sequence was produced by which organism in a symbiotic ecosystem: it was 99% accurate on high-quality validation data.
  • Autoimmune diseases are painful and debilitating conditions which affect millions of people in the United States and all over the world. At present such conditions are often difficult to diagnose and many have no satisfactory treatment. Given the wealth and availability of genomic data such as genetic variation and gene expression, computational integrative methods provide a powerful opportunity to improve human health by refining the current knowledge about diagnostics, therapeutics and disease mechanism. For instance numerous genome-wide association studies (GWAS) performed across autoimmune diseases, provide a great opportunity to study disease relationships based on genetic variation. Comparing such profiles allows us to quantify allele-specific pair-wise relationships between these diseases to find two broad clusters of autoimmune disease. We furthermore find that certain polymorphisms, toggle SNPs, predispose individuals to one class of autoimmune disease but are protective against the other class. While studying allelic differences between diseases may point to key novel disease-specific genes and pathways, studying similarities across diseases might lead to discovery of common therapeutic options as well as common disease mechanisms. In particular we integrate genetic variation data across several studies to discover the role of a complement factor in Rheumatoid Arthritis and Multiple Sclerosis. Gene expression microarrays are also often used to study human diseases as well as the perturbation of biological systems by drug compounds providing an opportunity to discover novel relationships between diseases and drugs. We present a systematic computational method to predict novel therapeutic indications based on gene expression. We tested our top prediction for Crohn's disease (CD) using the rat model of inflammatory bowel disease (IBD), and successfully demonstrated the predicted efficacy of an anti-seizure drug in treating disease. In this work, we have showed that integrative computational tools can be used to improve diagnostics, learn more about disease mechanism and discover novel therapeutics for autoimmune disease.
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    Want to communicate clearly, honestly and directly, without avoidance or resorting to manipulative or aggressive behaviour? Learn how to be assertive and explore its advantages as the primary tool of effective communication skills in healthcare settings. If you work in health or social care as a manager or clinician, deal with people on a daily basis, and need these dealings to be thoughtful, effective, and stress free, this is the book for you. It teaches you how to understand and alleviate barriers to effective communication, manage the stresses and conflicts, and develop the effective clinical, people and management skills you need to navigate successfully through a career in healthcare. It challenges the reader to re-construct their approach to communication and present themselves more confidently whilst encouraging investment in their personal and professional development. This highly practical guide, and its companion volume Developing Leadership Skills for Health and Social Care Professionals is a tool for all health and social care professionals wanting to develop relationships with their colleagues, patients and clients including clinicians, practice managers, nurses, midwives, general practitioners, therapists, doctors, dieticians, psychological therapists, paramedics and health visitors.
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    Introduction to the developing human -- The beginning of human development: first week -- Formation of bilaminar embryonic disc: second week -- Formation of germ layers and early tissue and organ differentiation: third week -- Organogenetic period: fourth to eighth weeks -- The fetal period: ninth week to birth -- the placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- The pharyngeal apparatus -- The respiratory system -- The digestive system -- The urogenital system -- The cardiovascular system -- The skeletal system -- The muscular system -- The limbs -- The nervous system -- The eye and ear -- The integumentary system -- Congenital anatomical anomalies or human birth defects -- Common signaling pathways used during development.
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    Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth: the fetal period -- Placenta and fetal membranes -- Body cavities and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
  • Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth : the fetal period -- Placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
  • This book reviews the current basic and clinical research into the mechanisms of cartilage injury and its management. It illustrates the considerable progress made in the search for solutions to cartilage related problems. Developing Insights in Cartilage Repair describes fundamental research and the use of biomaterials, bioreactors, and imaging as part of existing cartilage repair strategies, while revealing the on-going trends for emerging techniques. The aim of the Editors and their team of authorities in cartilage medicine has been to provide a link between laboratory work and the daily treatment of patients in a clinical setting. This book reveals the highly multidisciplinary nature of the topic and it will thus not only be of considerable interest to a large proportion of the orthopaedic community, but also any discipline in which cartilaginous tissue is involved, including otorhinolaryngology and plastic surgery.
  • Also available: Print – 2005
  • Many cellular processes including cell-cell communications and regulated membrane transport are mediated by membrane proteins and depend upon the ability of lipid membranes to be a differentially permeable barrier. However, the roles and function of membrane proteins are often difficult to study due to the complexity of the native membranes and lack of reliable and flexible artificial model lipid membranes. Supported lipid bilayers (SLB) have been used as a model system to study biological membrane behavior and the structure and function of membrane proteins and receptors in a simpler context apart from the complex cellular environment. Although SLBs have the advantages of simple formation, easy handling and are well-suited for investigation by a suite of surface sensitive methods due to their planar geometry, the close proximity of the lower leaflet to the solid support often leads to unfavorable interactions with integral membrane proteins. This causes distortion of the protein conformation and possible loss of its reactivity and function. Moreover, this interaction with the substrate often traps proteins and reduces their mobility in the membranes. Recognizing this limitation, we have developed a new model membrane architecture in which the DNA-tethered lipid bilayer is either to fixed DNA on a surface or to laterally mobile DNA displayed on a supported bilayer. This separates the lipid membranes from surface interactions and provides a more favorable environment for integral membrane protein with large globular domains. With mobile DNA hybrid tethers, stable tethered bilayers were made with specific lipid composition, while those with fixed tethers are stable regardless of membrane composition. The mobile tethers between a tethered and a supported lipid bilayer offer a particularly interesting architecture for studying the dynamics of membrane-membrane interactions. By careful choice of composition, improved stability was obtained and we can investigate the lateral segregation of DNA hybrids when different lengths are present. Based on a theoretical model, the effects of population, length and affinity of DNA complexes are simulated and described. This model system captures some of the essential physics of synapse formation and is a step toward understanding lipid membrane behavior in a cell-to-cell junction. To demonstrate the excellent environment provided by DNA-tethered membranes for studying transmembrane proteins free from any surface interactions, the behavior of a transmembrane protein, the photosynthetic reaction center, reconstituted in the DNA-tethered membranes is investigated. Inspired by DNA-mediated membrane fusion studies of our group, we applied the DNA-machinery to achieve fusion of small (~ 100 nm) proteoliposomes for delivery of membrane proteins to either giant vesicles or DNA-tethered planar lipid membrane patches. The diffusion behavior of delivered proteins is measured and compared with those in supported bilayers. Also, the protein activity and orientation before and after fusion is analyzed. This will offer a feasible method to incorporate intact membrane proteins to already formed model membranes. In addition, the behavior of proteins during the fusion event will provide insight into the mechanism of DNA-mediated lipid membrane fusion. The geometry of our model membrane system directly mimics that of a neuronal synapse. We expect that this architecture will be readily transferable to other model membrane fusion systems, including systems using reconstituted SNARE proteins. Consequently, it will be of considerable interest to a wide range of researchers.
  • Developing novel therapies for gram-negative bacterial infections and glioblastoma multiforme I. cloning and characterization of the guadinomine biosynthetic gene cluster II. developing a novel chemo-sensitizing agent to treat glioblastoma. This thesis explores the development of novel therapies for the treatment of two complicated problems: Gram-negative bacterial infections and glioblastoma multiforme, the most aggressive form of brain cancer. Part I of the thesis summarizes the current body of knowledge regarding guadinomines, their biosynthesis and implications for developing novel anti-infective agents. Part II of the thesis summarizes the development of the small molecule, ERW1227B, and its ability to sensitize glioblastoma cells to standard therapies. Part I. Guadinomines are a recently discovered family of anti-infective compounds produced by Streptomyces sp. K01-0509. They are the first microbial metabolites shown to inhibit the Type III Secretion System (TTSS) of Gram-negative bacteria. The TTSS is required for the virulence of many pathogenic Gram-negative bacteria including Escherichia coli, Salmonella spp., Yersinia spp., Chlamydia spp., Vibrio spp., and Pseudomonas spp. Inhibition of the TTSS can mitigate virulence which is important considering that Gram-negative bacteria infect millions each year, leading to considerable morbidity and mortality. The guadinomine (gdn) biosynthetic gene cluster has been sequenced, and encodes a chimeric multimodular polyketide synthase -- nonribosomal peptide synthetase spanning 26 open reading frames and 51.2 kb. It also encodes enzymes responsible for the biosynthesis of the unusual aminomalonyl-ACP extender unit and the signature carbamoylated cyclic guanidine. Its identity was established by genetic inactivation of the cluster, as well as heterologous expression and analysis of enzymes in the biosynthetic pathway. Identifying the guadinomine gene cluster provides critical insight into the biosynthesis of these biologically important compounds. Part II. Glioblastomas display variable phenotypes that include increased drug-resistance associated with enhanced migratory and anti-apoptotic characteristics. These shared characteristics contribute to failure of clinical treatment regimens. Identification of novel compounds that both promote cell death and impair cellular motility is a logical strategy to develop more effective clinical protocols. Previously, we described the ability of the small molecule, KCC009, a tissue transglutaminase inhibitor, to sensitize glioblastoma cells to chemotherapy. In the current study, we synthesized a series of related compounds that show variable ability to promote cell death and impair motility in glioblastomas, irrespective of their ability to inhibit TG2. Each compound has a 3-bromo-4,5-dihydroisoxazole component that presumably reacts with a nucleophilic cysteine thiol residue in one (or more) target protein(s) that have affinity for the small molecule. Our studies focused on the effects of the compound, ERW1227B. Treatment of glioblastoma cells with ERW1227B was associated with both down-regulation of the PI-3 kinase/Akt pathway, which enhanced cell death; as well as disruption of focal adhesions and intracellular actin fibers, which impaired cellular mobility. Bioassays as well as time-lapse photography of glioblastoma cells treated with ERW1227B showed cell death and rapid loss of cellular motility. Mice studies with in vivo glioblastoma models demonstrated the ability of ERW1227B to sensitize tumor cells to cell death after treatment with either chemotherapy or radiation. The above findings identify ERW1227B as a potential novel therapeutic agent in the treatment of glioblastomas.
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  • Understanding the general laws of an effective system for the transport of substances in cells is an important goal of systems and synthetic biology and will help us to answer why the transport subsystem of a cell is arranged as it is. In addition, the construction of models for optimizing transport systems is of considerable importance in the early stages in the development of a functioning protocell. The aim of this book is to describe the latest techniques for the calculation of the optimal parameters of the transport subsystem of a cell at its maximum efficiency.
  • Coral reefs are animal-built structures that provide habitats for a disproportionately large number of marine species relative to the small percentage of the ocean that they cover. Corals, and some other cnidarians such as anemones, host dinoflagellates within the cells of their gastrodermal tissue. The dinoflagellates fix carbon photosynthetically and transfer it to the host; the dinoflagellates can provide up to 90% of the hosts' metabolic requirements. The symbiosis between the cnidarian host and its dinoflagellate symbiont is therefore the trophic foundation on which coral reef are built. Despite its importance, the molecular mechanisms controlling symbiosis establishment, maintenance, and breakdown remain poorly understood. Our lab is working to further develop the small sea anemone, Aiptasia, as a model system for studying cnidarian-dinoflagellate symbiosis. To this end, I sequenced the transcriptome of aposymbiotic Aiptasia, of symbiotic Aiptasia, and of the dinoflagellate symbionts. I then used these resources to perform gene-expression analysis comparing symbiotic and aposymbiotic anemones, which provided numerous testable biological hypotheses about both the structural basis of the symbiosis and the downstream metabolic effects of metabolite transfer to the host. These resources should serve as the foundation for future experiments in our laboratory and more widely in the field of coral biology.
  • "A comprehensive assessment of biomarkers, this book covers the history and current status of the application of biomarkers in diagnostics and prognostics. It explores the technology used for the study of biomarkers, and the validation of biomarkers including a comparison of the various technologies used to identify and measure biomarkers. The editors emphasize the technology underlying biomarkers and the translation of basic science to clinical laboratory technology, including the commercial development of biomarkers. The book also covers proteomics and proteomic technologies and their applications in the identification of biomarkers"--Provided by publisher.
  • Embryonic development is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. This process depends on spatial and temporal control of gene function, and deciphering the molecular mechanisms that underlie pattern formation requires novel methods for perturbing gene expression with similar precision. Synthetic reagents can help meet this demand, and in this thesis I describe the development and application of caged morpholino (cMO) oligonucleotides for inactivating genes in zebrafish and other optically transparent organisms with spatiotemporal control simply by irradiating embryonic tissues with a focused light beam. In chapter 1 I provide an overview of the zebrafish model system of vertebrate development and survey the capabilities and limitations of various oligonucleotide-based technologies for perturbing RNA function and tracking RNA expression in zebrafish. I examine various light-gated oligonucleotide technologies that exploit the optical transparency of zebrafish embryos, including cMOs, for achieving spatiotemporal control of RNA function. In chapter 2 we describe the initial synthesis of a cMO targeting expression of the no tail a (ntla) transcription factor. By permitting spatiotemporal gene regulation in zebrafish embryos, the ntla cMO was used to make initial observations into the time-dependent role of this gene in notochord formation. In chapter 3 we report optimized methods for the design and synthesis of hairpin cMOs, incorporating a dimethoxynitrobenzyl (DMNB)-based bifunctional linker that permits cMO assembly in only three steps from commercially available reagents. Using this simplified procedure, we have systematically prepared cMOs with differing structural configurations and investigated how the in vitro thermodynamic properties of these reagents correlate with their in vivo activities. Through these studies, I have established general principles for cMO design and successfully applied them to several developmental genes. Our optimized synthetic and design methodologies have also enabled us to prepare a next-generation cMO that contains a bromohydroxyquinoline (BHQ)-based linker for two-photon uncaging. Collectively, these advances established the generality of cMO technologies to facilitate the application of these chemical probes in vivo for functional genomic studies. Finally, in chapter 4 we illustrate the utility of the cMO technology in isolating spatiotemporally-distinct functions of transcription factors -- genes that play diverse roles during embryonic development, with each controlling multiple cellular states in a spatially and temporally defined manner. Resolving the dynamic transcriptional profiles that underlie these patterning processes is essential for understanding embryogenesis at the molecular level; however, probing in vivo gene function with comparable spatiotemporal precision has been a technological challenge. To address this need, I have integrated cMOs with similarly caged fluorophores, fluorescence-activated cell sorting (FACS), and microarray technologies. Using this approach, I have dynamically profiled the No tail-a (Ntla)-dependent transcriptome at different stages of zebrafish mesoderm development, discovering discrete sets of genes that are associated with either notochord cell fate commitment or subsequent changes in cell function. Our studies elucidated the roles of several Ntla-regulated genes in notochord development and demonstrated the activation of multiple transcriptomes within a cell lineage by a single transcription factor.
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  • The ability to generate robust quantitative high-throughput protein abundance estimates directly from clinical samples would be useful for translational biomedical research. Knowing the protein content and abundance of a clinical sample would enable, for example, effective biomarker discovery, risk stratification of patient outcomes, and the ability to better understand disease mechanisms. Mass spectrometry has emerged as a powerful tool in the high-throughput measurement of proteins from human tissues and fluids. We are now beginning to have access to proteomics data of the coverage (hundreds to thousands of proteins), scale (tens to hundreds of samples), and throughput (a few days to weeks per experiment) to bring mass spectrometry proteomics to the study of clinical questions. In this work, we discuss methods for quantitation of peptide and protein abundance from mass spectrometry proteomics data. We apply our approaches to identify key proteins that are differentially expressed in the urine of kidney transplant patients with acute rejection. We also investigate the response of the human plasma proteome to severe burn injury. We characterize the protein composition of T-cells, monocytes, and neutrophils of trauma patients, healthy controls, and stimulated cells, and compare information content of proteomics data from these cell populations with gene expression data from similar samples. Finally, we discuss a novel metric for scoring normalization algorithms from mixture titration quality control experiments, and we apply this metric to proteomics and transcriptomics data. Through the methods for quantitation of peptides and proteins, application of proteomics to different clinical questions, and integration of proteomics with other high-throughput data, we demonstrate the utility of mass spectrometry based proteomics to the study of human biofluids in human disease research.
  • 1. Overview of the present work -- 2. The biopsychosocial and bio-personal-social models -- 3. Piaget and development -- 4. The present cognitive-affective stage model: I cognition -- 5. The present models: II postformal stage, neo-Eriksonian parallels, systems -- 6. Substages in the neo-piagetian models of Case, Fischer, and Young -- 7. Parallels in cognitive substages and socioaffectivity in Case -- 8. Parellels in cognitive substages and socioaffectivity in Fischer -- 9. Case and Fischer on language and the brain -- 10. Recent Case and colleagues -- 11. Further Fischer: comprehensive summary, adult development -- 12. Recent Fischer: emotional development -- 13. Self-development -- 14. Cognitive (mis)perception of the self and other -- 15. Social cognition/theory of mind -- 16. Self-definition and relatedness/self-regulation in development -- 17. Cognitive/socioaffective complexes and multiple intelligences -- 18. Postformal thought: commons' model -- 19. Development of personality and motivational needs -- 20. Socioemotional systems and neo-Eriksonian dangers -- 21. Approaches to emotions -- 22. Emotional development in infancy -- 23. Attachment basics -- 24. Internal working models and social self working schemata -- 25. Development of hemispheric specialization -- 26. Lateralization and developing cognition -- 27. Systems and development -- 28. Attractors, complexity -- 29. Causes and determinants of behavior -- 30. Gene-environment interactions: other topics --31. Stages and change in development and other systems -- 32. Collective intelligence and multilevel selection -- 33. Narrative discourse coding: cohesion in children's narratives -- 34. Narrative discourse coding: syntactic complexity-errors -- 35. Book conclusions.
  • Also available: Print – 2009
    Development of the dopamine systems in zebrafish / Jørn Schweitzer and Wolfgang Driever -- Dopamine systems in the forebrain / John W. Cave and Harriet Baker -- The role of Otx genes in progenitor domains of ventral midbrain / Antonio Simeone ... [et al.] -- Terminal differentiation of mesodiencephalic dopaminergic neurons : the role of Nurr1 and Pitx3 / Marten P. Smidt and J. Peter H. Burbach -- Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons / Siew-Lan Ang -- Transcriptional regulation of their survival : the engrailed homeobox genes / Horst H. Simon and Kambiz N. Alavian -- Neurotrophic support of midbrain dopaminergic neurons / Oliver von Bohlen und Halbach and Klaus Unsicker -- TGF in dopamine neuron development, maintenance, and neuroprotection / Eleni Roussa, Oliver von Bohlen und Halbach, and Kerstin Krieglstein -- Axon guidance in the dopamine system / Asheeta A. Prasad and R. Jeroen Pasterkamp -- Protocols for generating ES-cell-derived dopamine neurons / Sonja Kriks and Lorenz Studer -- Molecular and cellular determinants for generating ES-cell-derived dopamine neurons for cell therapy / -- Jan Pruszak and Ole Isacson.
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  • Also available: Print – 2005
    Section I. Neuronal network formation. Neuronal network formation in human cerebral cortex -- Section II. Molecular and cell biological mechanisms of neuronal network development and synapse formation. Regulation of dendritic growth by calcium and neurotrophin signaling. Dynamics and pathology of dendritic spines. Introduction to the sixteenth C.U. Ariens Kappers lecture. Mechanisms of retinotopic map developments: Ephs, ephrins, and spontaneous correlated retinal activity. Biologically plausible models of neurite outgrowth. Competition in neurite outgrowth and the development of nerve connections -- Section III. Synapse rearrangement. Molecular substrates of plasticity in the developing visual cortex. Excitatory-inhibitory balance and critical period plasticity in the developing visual cortex. Structural plasticity in the developing visual system. Mechanisms controlling the formation of retinal mosaics. Laminar circuit formation in the vertebrate retina -- Section IV. Structure and dynamics in neurons and neuronal networks. Dynamics and plasticity in developing neuronal networks in vitro. Learning in ex-vivo developing networks of cortical neurons. Role of synaptic inhibition in spatiotemporal patterning of cortical activity. Synaptic mechanisms that shape visual signaling at the inner retina. The involvement of glutamate-gated channels in negative feedback from horizontal cells to cones. Compensatory physiological responses to chronic blockade of amino acid receptors during early development in spontaneously active organotypic cerebral cortex explants cultured in vitro -- Section V. Dynamics in neural circuits in cognition. A visual salience map in the primate frontal eye field. Chronic multiunit recordings in behaving animals: advantages and limitations -- Section VI. Deficient circuitry and cognitive/behavioral pathology. Physiological studies of information processing in the normal and Parkinsonian basal ganglia: pallidal activity in Go/No-Go task and following MPTP treatment. Rho proteins, mental retardation and the neurobiological basis of intelligence. Neurodevelopment, neuroplasticity, and new genes for schizophrenia. The impact of seizures on developing hippocampal networks. Alzheimer's disease as a disorder of dynamic brain self-organization.
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  • Trauma patients require rapid diagnosis and treatment of hemorrhage. In the hospital, experienced sonographers can reliably diagnose vascular injury using duplex ultrasound. In trauma settings, such as the battlefield, a portable ultrasound device with an automated algorithm to detect bleeding would be useful for medics. Thus, an increasing interest in computer-aided bleed detection led to efforts in quantifying sonographic signatures of abnormalities at the site of vascular injury. However, since trauma patients often present with large areas of injury, there is a need to develop and evaluate bleed detection strategies for ultrasound that more efficiently assess a large vascular tree. The goal of this Ph.D. research dissertation is to address this need. The studies primarily focused on the upper extremity vasculature, specifically the brachial bifurcation, because the leading cause of preventable deaths due to vascular trauma has been exsanguinations from extremity injuries. The overall approach was to characterize normal blood flow with a well-established power law model and identify flows that deviate from the model. The power law states that blood flow is proportional to the vessel diameter raised to a power index k, where k is defined by the bifurcation geometry. A bleed detection metric, called the "flow split deviation" (FSD), was defined to quantify the flow deviations from the power law. Validation of this approach was undertaken in four steps. The first involved demonstrating that the power law model appropriately describes the normal brachial bifurcation and flows in man. The utility of the bleed metric was then evaluated with 3D computational models of bleeds. Finally, the proposed detection algorithm was applied on the early proof of concept humans in arteriovenous fistulas (AVF) of dialysis patients and in in vivo rabbit bleed models. A study with normal human subjects was used to determine that the best-fit k for the brachial bifurcation was 2.75, which is in agreement with other vasculatures previously studied. A k=2.75 power law was then shown to adequately predict forearm blood flows for both resting and exercise physiological states. The correlation coefficient R between predicted and measured normal flows was 0.98. Computational models suggested that FSD was a good indicator of the severity of bleed downstream from the bifurcation. In the patient case study, the bleed metric easily distinguished between normal arms and those with newly placed wrist AVFs, which caused on average an order of magnitude increase in flow deviations. Introduction of different femoral bleed rates in rabbits demonstrated good sensitivity and specificity of the bleed metric when applied to moderate lower extremity bleeds. Bifurcation FSDs can serve as a quantitative signature of bleeding and, moreover, as a strategic way to survey large vascular trees by following abnormal branch points to the likely source of hemorrhage. This approach can complement other quantitative sonographic methods to create a comprehensive, automated, ultrasound-based algorithm for vascular trauma detection.
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  • Astrocytes constitute more than half of the human brain, yet their functions have yet to be fully elucidated largely due to a lack of a good and pure in vitro culture system. The inability to purify and culture brain astrocytes has long hindered studies of their function. Although astrocyte progenitor cells can be cultured from neonatal brain, culture of more differentiated mature astrocytes from postnatal brain has not previously been possible. Here I report a new method for the prospective purification of astrocytes by immunopanning (IP-astrocytes) and have used this method to investigate several fundamental properties, functions of astrocytes and neuron-glial interactions. I show that these highly purified astrocytes, like neurons, undergo apoptosis in culture, but that vascular cells as well as exogenous HBEGF and Wnt7a strongly promote their survival in serum-free culture. Similarly, I found that developing astrocytes in vivo undergo apoptosis and that the vast majority of surviving astrocytes in vivo contact blood vessels and hypothesise that developing astrocytes may normally be matched to blood vessels by competing for a limited supply of vascular trophic factors. In contrast to the more traditional neonatal astrocyte cultures prepared via a method developed by McCarthy and de Vellis (1980) (MD-astrocytes), the gene profiles and functions of the purified postnatal astrocytes in serum-free culture much more closely resembled that of astrocytes in vivo. These astrocytes also strongly promoted synapse formation and function. I have also identified genes that are induced by serum and show that serum exposure to astrocytes causes massive and irreversible changes of gene expression as well as astrocyte function. In addition, I have highlighted several features of MD-astrocytes that are different from IP-astrocytes. Together, the data suggests that I have developed a culture system that is more representative of the in vivo state. This culture system will be of interest to a broad range of neuroscientists as it provides a simplified and tractable system to study the functions and properties of astrocytes both in the normal and diseased states.
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  • This book discusses research and theory on how motivation changes as children progress through school, gender differences in motivation, and motivational differences as an aspect of ethnicity. Motivation is discussed within the context of school achievement as well as athletic and musical performance.
  • 1. Translational Strategies for Development of Antibody-Based Therapeutics: An Overview / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp -- 2. Discovery Process for Antibody-Based Therapeutics / Heather H. Shih -- 3. Technologies for the Generation of Human Antibodies / Ramesh R. Bhatt, John S. Haurum and C. Geoffrey Davis -- 4. Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics / Randall J. Brezski and Juan Carlos Almagro -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics / Andrew W. Drake and Giuseppe A. Papalia -- 6. Considerations in Establishing Affinity Design Goals for Development of Antibody-Based Therapeutics / Mohammad Tabrizi -- 7. Bioanalytical Considerations for Development of Antibody-Based Therapeutics: Pharmacokinetics and Immunogenicity / Cherryl B. Funelas and Scott L. Klakamp -- 8. Preclinical Considerations for Development of Antibody-Based Therapeutics in Oncology / Gregory Landes and Kathleen Elias -- 9. Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology / David C. Blakey -- 10. Preclinical Safety Considerations for the Development of Antibody-Based Therapeutics / Lolke de Haan -- 11. Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therapeutics / Donald E. Mager -- 12. Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics / Feng Jin -- 13. Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics / Mohammad A. Tabrizi and Cherryl B. Funelas -- 14. Translational Research in Alzheimer's Disease for Development of Antibody-Based Therapeutics / Eric C. Yuen, Enchi Liu and Gene G. Kinney -- 15. Considerations in Manufacturing Process Development for Antibody-Based Therapeutics / Paula C. Miller and Peiling Xu -- 16. Strategies for Development of Next Generation Antibody-Based Therapeutics / Mohammad Tabrizi and Gadi Gazit Bornstein -- 17. Immune Complex Therapies for Treatment of Immune Thrombocytopenia / Rong Deng and Joseph P. Balthasar -- 18. Application of Bioinformatics Principles for Target Evaluation / Anthony Carvalloza, Mohammad Fallahi and Sahba Tabrizifard -- 19. Concluding Remarks / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp.
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  • Studying the effects of gene expression in biological systems has traditionally been undertaken by measuring phenotypic response at a limited number of expression levels. Typically the effects of gene expression are assayed at a high level of overexpression and compared to physiological levels of expression; however, many examples exist in which the level of gene expression greatly affects the resulting cellular phenotypes. Of particular interest for our purposes is the interplay between oncogenes in driving tumorigenesis and cancer progression. For example, oncogene H-Ras is capable of both enhancing cellular proliferation at intermediate levels expression levels (doses) and causing cell cycle arrest and senescence at high expression levels. In order to more thoroughly investigate such behavior we have created a set of tools for measuring dose-dependent effects of gene expression. These tools consist of promoter library to drive wide range gene expression, single-cell proliferation measurements, and data analysis methods to calculate correlation curves between gene expression level and phenotype response. The system is designed for cell-by-cell measuring of both expression level and phenotype response by flow cytometry. This approach allows for full dose experiments to be performed in a single heterogeneous culture with individual cells accessing different expression levels for a given phenotype. Because we are interested in studying the cell biology and genetics of tumor cells, measuring the phenotype of proliferation rate was of particular interest. To aid in further investigation of proliferation rate response to gene overexpression a genetic proliferation reporter was developed. This reporter utilizes the cell cycle-dependent activity of the E2F class of transcription factors, which are active during the G1/S transition. The highly stable fluorescent proteins EGFP and mCherry are expressed from both an E2F-responsive and constitutive promoter, respectively. The ratio of fluorescence levels correlates to proliferation rate in a variety of cell lines, matching predictions made initially by computational model. Finally, given a culture containing expression of a gene or combination of genes by the promoter library and phenotype measurement, the data collected from those cells must be analyzed to determine a correlation curve representing the dose response of the phenotype to level of expression of the genes of interest. In order to calculate this curve from the flow cytometry data several empirical analysis methods were evaluated. We determined the locally weighted scatter plot smoothing (LOWESS) curve fitting method to be best for our purposes of fitting the dose-response curves. As the LOWESS fits of flow cytometry data represented a technical hurdle to performing the dose-response experiments a custom software package was created to allow for easy implementation of the constitutive promoter library for studying dose-dependent behavior. The result is a set of biological and computational tools that allow for high throughput evaluation of gene dose effects. Further effort has been undertaken to move the system to evaluate multiple genes simultaneously, with the ultimate goal of being able to measure genetic cooperation.
  • Cancer arises from the alteration of genes and the deregulation of the inherent control mechanisms existing with a cell. Cancer progression is the result of several of these genes or pathways being altered. Unfortunately, its analysis is not as straightforward as identifying a handful of discrete, independent mutational events occurring within a cell. Rather, these genes, pathways, and other regulatory elements are interconnected. Altering the expression level (dose) of one gene can have direct and indirect effects on many additional genes/pathways. Furthermore, combinations of genes can interact to have collaborative or antagonistic effects that are greater than or less than the sum of their individual contributions. It is not enough to study the effects of single genes/pathways at a few discrete expression levels. To this end, we have developed genetic tools that allow for controlling gene expression over a full range. Controlling gene expression at the level of transcription allowed for a 40-fold range of expression to be investigated. However, the range in expression of the transcriptionally controlled system varied across cell lines. Expanding beyond this system, we have turned to controlling gene expression at the level of translation. Using translational control elements, we were able to varying gene expression over a 200 -- 300-fold range. Furthermore, the translational control system was shown to be consistent across six different cell lines and with every transgene that has been tested to date. To address the fact that cancer progression is a multi-faceted event, we developed a system that would allow observation of the effects resulting from the interactions of multiple genes. By using retroviral vectors equipped with fluorescent protein fusions, we successfully derived a system that has the capacity to interrogate up to three genes of interest within a single culture of cells. This single culture makes it logistically feasible to study such large combinations of gene dosage levels. This single culture is heterogeneous in expression for each of the transgenes introduced; and by utilizing flow cytometry, the precise dosage level of each transgene can be correlated to measureable phenotypes at the single-cell level. To demonstrate how the tools we have developed can be utilized to quantitatively assess gene-dosage profiles, we ectopically controlled the expression of various mutant forms of the oncogenic version of H-Ras (H-RasG12V) in both murine fibroblast and pre-B cells. We chose to study proliferation as a measurable phenotypic read-out. In NIH/3T3 fibroblasts we observed a maximum in proliferation at low levels of expression of H-RasG12V. A mutant version, H-RasG12V T35S, which is only able to signal down the MAPK pathway, exhibited maximal proliferation at intermediate expression levels. Other H-Ras mutants did not exhibit any proliferation optima when expressed by themselves. In contrast, when the mutants were investigated in pairwise fashion, some cooperation could be observed between particular mutant pairs. Finally, the effect of these H-Ras mutants on proliferation was investigated in a murine pre-B cell line. By adding a reference population of cells to a culture of cells expressing H-Ras mutant oncogenes over a range of expression levels, we were able to track the population dynamics between these two subsets of cells. A simple mathematical approach will be detailed to demonstrate how we can calculate the net proliferation rate as a function of H-Ras expression level by tracking the distribution of these two cell populations over time.
  • The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
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  • A central goal in neuroscience is to explain animal behavior in terms of causal cellular processes. It has been a longstanding challenge, however, to simultaneously track behavior and the cellular dynamics driving it. In this thesis, I discuss how a series of one- and two-photon fluorescence microscopes, based on gradient refractive index (GRIN) lenses, were developed to meet this challenge. The predominant difficulty in the design of these microscopes was how to take a traditional bench top microscope and shrink it to a size small enough for a mouse to easily carry on its head, a limit of 3 grams. We chose mice as our design target due to the wide availability of genetically modified mouse models for the study of cognitive functions, animal behaviors, and disorders of the nervous system. The earlier devices, relying on fiber optics to bring light to and from the animal, met with limited success but still provided useful insight in the development of the surgical techniques and analytical tools necessary for later successful experiments. In contrast, our latest system fully integrates the entire light pathway onto the head of mouse, eliminating many of the remaining roadblocks to truly freely-moving imaging. This device has enabled novel observations of both microcirculatory and neuronal calcium dynamics in the cerebellum of freely-moving mice at frame rates up to 100 Hz. As the genetic toolbox for mice continues to mature, these miniaturized microscopes will facilitate a wide set of future studies of how cellular function in the brain varies across different behavioral and physiological states.
  • General movements -- Startles, twitches and clonuses -- Hiccups, yawning and gasping -- Fetal breathing movements -- Swallowing, sucking and handedness as inferred from fetal thumb sucking -- Localized movements -- Facial expressions -- Rest-activity cycles, clusters and the ontogeny of sleep -- Twin fetuses and twin myths -- Conclusions: movement is life.
  • Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
  • The development of live cell RNA imaging techniques will lead to the unraveling of many important biological processes. To achieve this goal, there have been three different strategies developed. They are the development of small molecule probes, nucleic acid probes, and green fluorescent protein (GFP) probes. In the following thesis, the pros and cons of each approach are discussed, followed by a proposal to resolve the limitations. In the small molecule case, a probe was developed that utilized a quenched sulforhodamine dye. It was designed so that its structure can be rationally modified from the initial lead compound. An aptamer sequence that activates the sulforhodamine probe with micro molar affinity was found by in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX), followed by fluorescence screening in E.coli. The rational modification of the structure of the initial sulforhodamine probe resulted in an overall 33-fold increase in binding affinity compared to the initial lead compound. Instead of the chemical modification of the lead compound, the small molecule's cell permeability and binding affinity to the target could be improved by linking to cell penetrating peptides (CPP). A CPP is a short peptide sequence composed of poly arginine amino acids which shows excellent cell uptake and affinity to RNA. However, the use of the CPP-linked dye in live cell imaging has been limited by strong signals in the endosome region. An attempt was made to overcome this difficulty by linking a quencher molecule to the dye-CPP via a disulfide bond, which only breaks when it enters the cytosol. For the nucleic acid probe, the major problem was its low cell permeability and low signal-to-background ratio due to the low copy number of mRNA targets within the cell. We made mutant Hammerhead ribozymes and embedded them in a non-coding region of the GFP expression vector that can be transfected to mammalian cells. This modified Hammerhead ribozyme acts as a logic gate, and the signal is amplified by the expression of GFP in the presence of the target mRNA. In vitro and in vivo results are discussed. Finally, a fragmented GFP system, the fluorescence of which could be recovered by binding to a specific RNA tag, was developed. The major problem for the GFP-mediated RNA imaging system was the low signal-to-background ratio from the GFP probe that is not bound to the RNA tag. To find the non-fluorescent GFP, the GFP was truncated from the C-terminus such that it loses its fluorescence with minimum loss of amino acids. An RNA sequence that has high affinity to this GFP was found by in vitro SELEX. The subsequent E.coli screening found an RNA sequence that reactivates the fluorescence of the GFP probe.
  • Fluorescence microscopy is one of the most widely used tools in cell biology due its intrinsically high detection sensitivity coupled with the ability to genetically label proteins and other cellular structures with fluorescent tags. However, the resolution of fluorescence microscopy has historically been limited to about 200 nm laterally and 800 nm axially because of the diffraction limit of visible light. In the past five years, imaging below the diffraction limit ("super-resolution imaging") by localizing single fluorophores, one at a time (1-3), has opened a wide a variety of new biological systems for study. This Dissertation is a collection of both techniques for two and three dimensional super-resolution imaging as well as applications in bacterial and yeast imaging. References 1. Betzig E, et al (2006) Imaging intracellular fluorescent proteins at nanometer resolution. Science 313: 1642-1645. 2. Hess ST, Girirajan TPK & Mason MD (2006) Ultra-high resolution imaging by fluorescence photoactivation localization microscopy. Biophys J 91: 4258-4272. 3. Rust MJ, Bates M & Zhuang X (2006) Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat Methods 3: 793-795.
  • Templated fluorescence activation is an elegant nucleic acid detection technique, which relies on a target-activated chemical reaction between two oligonucleotide probes, eliciting a fluorescence readout. This method reports on genetic markers in solution phase and in cells. The research described in this thesis was aimed to expand the reaction scope of templated fluorescence activation and to develop probes, which overcome shortcomings of previous designs. Examples of DNA template-mediated fluorogenic reactions developed during this project include an organomercury-induced cyclization of Rhodamine thiosemicarbazide and the deprotection of a 7-azidomethoxycoumarin profluorophore by a Staudinger reaction. The most promising probe design (Q-STAR probes) is based on the reductive cleavage of an [alpha]-azidoether quencher release linker conjugated to a fluorophored-labeled DNA. A triphenylphosphine DNA-probe rapidly activates Q-STAR probes in the presence of the matched DNA target strand, reporting its presence by a strong fluorescence turn-on signal. Q-STAR probes are inert to aqueous conditions and cellular components, properties that were suboptimal for previous probe designs. Q-STAR probes report the target with single nucleotide specificity and enable an amplified detection signal by harnessing the target as a catalyst for the templated reaction. Q-STAR probes efficiently detect the presence of rRNAs in bacteria and mammalian cells. The probes are responsive to single nucleotide differences, which allows discriminating bacteria species by genetic variations using fluorescence microscopy or flow cytometry. Similarly, rRNAs in mammalian cells generate a strong fluorescence turn-on signal for Q-STAR probes. Templated fluorescence activation schemes bear considerable promise for applications in clinical diagnostics and molecular biology. The probe designs described in this thesis, in particular Q-STAR probes, constitute a major advancement in the field and will help achieve these goals.
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  • Pancreatic development as a basis for the definition of new therapies for diabetes / Scharfmann, R. -- Overview of neonatal diabetes / Hamilton-Shield, J.P. -- Transcription factors in pancreatic development. Animal models / Martin, M. ... [et al.] -- Distinct roles of HNF1[beta], HNF1[alpha], and HNF4[alpha] in regulating pancreas development, [beta]-cell function, and growth / Maestro, M.A. ... [et al.] -- In vivo and in vitro techniques to study pancreas development and islet cell function / Duvillié, B., Heinis, M., Stetsyuk, V. -- Functional imaging of the pancreas: the role of [18F]Fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy / Ribeiro, M.J. ... [et al.] -- Insulin pump therapy in neonatal diabetes / Tubiana-Rufi, N. -- Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes / Rutter, G.A. -- Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences / Flechtner, I. ... [et al.] -- Genomic imprinting: roles and regulation in development / Kelsey, G. -- Imprinting in human disease with special reference to transient neonatal diabetes and Beckwith-Wiedemann syndrome / Temple, I.K. -- The physiology and clinical management of glucose metabolism in the newborn / Beardsall, K., Dunger, D.
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    Talking with parents / Barbara Korsch -- Talking with children / Yi Hui Liu, Martin T. Stein -- Teachable moments in primary care / Barry Zuckerman, Steven Parker -- Touchpoints of anticipatory guidance in the first three years / T. Berry Brazelton, Joshua Sparrow -- Difficult encounters with parents / Barbara Korsch -- Helping families deal with bad news / Jack P. Shonkoff and Yvette E. Yatchmink -- Promoting early literacy / Perri E. Klass -- Family-focused behavioral pediatrics / Carol Hubbard, William Lord Coleman -- Promoting parental self understanding / Barry Zuckerman, Pamela M. Zuckerman -- Behavioral screening / Terry Stancin, Ellen Perrin -- Developmental screening / Frances Page Glascoe -- Screening for social and emotional delays in early childhood / Margaret J. Briggs-Gowan, Alice S. Carter -- Behavioral management: theory and practice / Edward R. Christophersen -- Coping with stressful transitions / W. Thomas Boyce -- Managing behavior problems in an office practice / Barbara Howard -- Pain / Neil L. Schecter -- Promoting development in developing countries / Ilgi Ozturk Ertem -- Self-regulation therapy / Karen Olness -- Psychopharmacology / Alison Schonwald -- Abdominal pain / Leonard Rappaport -- The aggressive, explosive child / Ross W. Greene and J. Stuart Ablon -- Anorexia nervosa and bulimia / Angela S. Guarda, Alain Joffe -- Anxiety disorders / Travis R. Adams, Margaret A. Swank, Bruce J. Masek -- Asperger's syndrome / Celine A. Saulnier & Fred R. Volkmar -- Attention deficit hyperactivity disorder / Steve Parker --Autism / Elizabeth B. Caronna -- Bad news in the media / Marilyn Augustyn, Betsy McAllister Groves -- Bipolar disorder in children / Janet Wozniak, Joseph Biederman -- Biting others / Barbara J. Howard -- Breath holding / Barry Zuckerman -- Bullying / Douglas Vanderbilt, Marilyn Augustyn -- Cerebral palsy / Frederick B. Palmer, Alexander H. Hoon -- Chronic conditions / Ellen C. Perrin -- Colic / Steven Parker -- Depression / Michael Jellinek -- Down syndrome / Siegfried M. Pueschel -- The dysmorphic child / John C. Carey -- Encopresis / Alison Schonwald, Leonard Rappaport -- Enuresis / Leonard Rappaport, Alison Schonwald -- Failure to thrive / Deborah Frank -- Fears -- Fetal alcohol syndrome / Barbara A. Morse and Lyn Weiner -- Fragile X syndrome / Randi Hagerman -- Gay, lesbian, & bisexual youth / C. Wayne Sells, M, Gary Remafedi -- Gender identity dilemmas / Ellen C. Perrin -- The gifted child / Eve Colson, Neil Schechter -- Headaches / Martin Stein -- Hearing impairment / Laurel M. Wills, Karen E. Wills -- Language or speech delays / James Coplan -- Lying, cheating, & stealing / Nerissa B. SanLuis, Martin T. Stein -- Masturbation / Ilgi Ertem, John Leventhal -- Mental retardation: behavioral problems / Theodore Kastner, Kevin Walsh -- Mental retardation: diagnostic evaluation / David L. Coulter -- Motor delays / Peter A. Blasco -- Neglect / Howard Dubowitz -- Nightmares and night terrors / Barry Zuckerman -- Obesity / Lawrence Hammer -- Physical abuse / Christine E. Barron, Carole Jenny -- Picky eating / Julie Lumeng -- Post traumatic stress disorder / Glenn Saxe -- Prematurity: primary care follow-up / James A. Blackman, Robert J. Boyle -- School avoidance / Barton D. Schmitt -- School failure / Paul H. Dworkin -- School readiness / Judith S. Palfrey -- Selective mutism / Naomi Steiner -- Self-esteem and resilience / Robert B. Brooks -- Sensory integration disorder / Marie E. Anzalone -- Sex and the adolescent / Linda Grant -- Sexual abuse / Deborah Madansky, Christine Barron, Carole Jenny -- Shyness / Jonathan M. Cheek / Sleep problems / Judith A. Owens -- Speech disorders / Rebecca McCauley -- Stuttering / Barry Guitar, Gayle Belin -- Substance use in adolescence / John R. Knight -- Suicide / Karen Norberg -- Temper tantrums / Robert Needlman -- Temperamentally difficult children / Stanley Turecki -- Thumb sucking / Stephanie Blenner -- Tics and Tourette's syndrome / Adrian D. Sandler -- Toilet training / Steven Parker -- Unpopular children / Melvin Levine -- Violent youth / Peter Stringham -- Visual impairment / Michael E. Msall -- Witness to violence / Betsy McAlister Groves -- Adoption / Nancy Roizen -- Bereavement and loss / Benjamin S. Siegel, Maria Trozzi -- Child care / Laura Jana -- Cultural responses to behavioral problems / Lee M. Pachter -- Divorce / Margot Kaplan-Sanoff -- Dying children / David J. Schonfeld, Melvin Lewis -- Foster care / Moira Szilagyi -- Gay and lesbian parents / Ellen C. Perrin -- Maternal depression and its effect on child development / Prachi Shah -- Sibling rivalry / Robert Needlman -- Single parents / J. Lane Tanner -- Stepfamilies / John S. Visher, Emily B. Visher, Margorie Engel -- Television / Victor C. Strasburger -- Twins / Jessie R. Groothuis -- Vulnerable children / Brian W.C. Forsyth.
  • "For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher's description.
  • Also available: Print – 2005
    The hedgehog signaling pathway in cancer / J. Vestergaard, Mads Bak, L.A. Larsen -- Rho GTPases and cancer / P. Buongiorno, B. Bapat -- Developmental biology of fibroblasts and neoplastic disease / D. Brouty-Boyé -- The extracellular matrix during normal development and neoplastic growth / J. Labat-Robert, L. Robert -- Wilms' tumor : starting off the kidney all over again? / M. Little -- Testicular teratomas : back to pluripotent stem cells / T. Kimura ... [et al.] / Tumor suppressors APC and VHL : gatekeepers of the intestine and kidney / R.H. Giles, E.E. Voest -- Hormonal and stromal regulation of normal and neoplastic prostatic growth / W.A. Ricke ... [et al.] -- Neoplastic growth through the developmental stages of the organism / A. Maciera-Coelho.
  • Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
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  • In this work, I present two studies of the evolution and function of developmental enhancers. In the first study, I describe the discovery of the first examples of cis-regulatory elements that are conserved across the two great clades of the bilaterian tree (deuterostomes and protostomes). These bilaterian conserved regulatory elements (Bicores) are developmental enhancers that respond to key signaling pathways and have been conserved for approximately 650 million years. In vertebrates, Bicores have neofunctionalized to drive expression in the central nervous system. In the second study, I present a genome-wide set of putative enhancers that function in the development of the mammalian neocortex. These elements, identified through ChIP-seq, are validated through both computational and experimental approaches. I show that many elements are anciently conserved beyond mammals, and we show that older elements are more likely to be pleiotropic. Pleiotropic elements most likely function in other aspects of central nervous system development, and elements that are conserved to zebrafish function in the developing zebrafish forebrain. I also provide evidence that specific repeat families have played a major role in the generation of enhancers that function in neocortex development. Finally, in the conclusion, I discuss how enhancer neofunctionalization and pleiotropy fit into a model of enhancer evolution and the evo-devo framework.
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    Genetic approaches -- Analysis of cell fate outcomes in transplantation models -- Animal models -- Bioinformatics and functional genomics.
  • Also available: Print – 2005
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    v. 1. Theory and method -- v. 2. Developmental neuroscience -- v. 3. Risk, disorder, and adaptation.
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    Part A. Embryos of the first three weeks (stages 1 to 9).
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  • Also available: Print – 2009
  • Pathophysiology of heart failure / M. Velez and N.K. Sweitzer -- Medical therapy for heart failure / N.K. Lakdawala and A. Desai -- Device trials in chronic heart failure: Implications of trial design / W.K. Laskey and R. Manring-Day -- The FDA perspective on heart failure devices / M.G. Hillebrenner ... [et al.] -- Hemodynamic monitoring in heart failure / A. Nohria and A. Bhatt -- Implantable cardioverter-defibrillators / R. Lampert and Z. Goldberger -- Cardiac resynchronization therapy / D. Frisch and P.J. Zimetbaum -- Pacing and defibrillation for atrial arrhythmias / J.M. Cooper -- Atrial fibrillation ablation / J.V. Wylie and M.E. Josephson -- Percutaneous treatment of coronary artery disease / R.J. Laham -- Percutaneous management of peripheral arterial disease / M.A. Sheikh and L.A. Garcia -- Percutaneous management of valvular heart disease / J.J. Wykrzykowska and J.P. Carrozza -- Ventricular assist devices and total artificial hearts / A. Blitz and J.C. Fang -- Device therapy for left ventricular dysfunction / C.W. Yancy.
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  • Indications and implantation for cardiac resynchronization therapy -- Do the official guidelines for cardiac resynchronization therapy need to be changed? -- Alternative techniques for left ventricular lead placement -- Importance of the right ventricular pacing site in cardiac resynchronization -- Alternative means of achieving cardiac resynchronization -- CRT-pacing only versus CRT-defibrillator -- Upgrading conventional pacemakers to CRT: indications and technical considerations -- Cardiac resynchronization for heart failure -- Update of cardiac resynchronization trials -- Cardiac resynchronization for heart failure: do we need more trials? -- Should cardiac resynchronization be considered for the prevention of heart failure? -- Left bundle branch block-induced cardiomyopathy: a new concept of mechanically induced cardiomyopathy -- Role of echocardiography before CRT implantation: can we predict nonresponders? -- Role of echocardiography after implantation of a cardiac resynchronization system -- Advances in technology -- Recent advances in the technology of cardiac resynchronization therapy -- Advances in left ventricular pacing leads -- New pacing algorithms and functions in CRT devices -- Significance of latency during left ventricular pacing for cardiac resynchronization therapy -- Programmability of the interventricular interval during cardiac resynchronization therapy -- Hemodynamic sensors in heart failure devices -- Assessment of single-shock defibrillation testing of biventricular ICDs -- Follow-up -- How to program CRT devices -- Programming and follow-up of CRT and CRTD devices -- Standard electrocardiogram during cardiac resynchronization -- Cardiac arrhythmias after cardiac resynchronization -- Advances in CRT device diagnostics -- Complex issues in the follow-up of CRT devices -- Recurrent heart failure and appropriate evaluation after cardiac resynchronization therapy.
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  • Also available: Print – v. 1-2., 2008
  • The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging -- Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas -- Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • "Cancer: Principles and Practice of Oncology presents the practicing oncologist with the practical as well as cutting-edge information needed to ensure the best possible care for each individual patient. To ensure a balanced multidisciplinary approach, a surgeon, a medical oncologist, and a radiation oncologist author each of the major treatment chapters. Each of the major treatment sections is preceded by an updated, brief chapter describing the molecular biology of that cancer and the prospects this new information holds for the improved management of cancer patients"--Provided by publisher.
  • Print Material
    Clinical anatomy of the pelvis and reproductive tract / Alan Farthing -- Maternal physiology / Fiona Broughton-Pipkin -- The placenta and fetal membranes / Berthold Huppertz and John C.P. Kingdom -- Normal fetal growth / Jason Gardosi -- Pre-conception counselling / Andrew McCarthy -- Antenatal care / Timothy G. Overton -- Normal labour / A.A. Calder -- Fetal monitoring during labour / James A. Low -- Analgesia and anaesthesia / John A. Crowhurst -- Puerperium and lactation / D. Keith Edmonds -- Neonatal care for obstetricians / M.A. Thomson and A.D. Edwards -- Spontaneous miscarriage / Joanne Topping and Roy G. Farquarson -- Recurrent miscarriage / Raj Rai -- Ectopic pregnancy / Davor Jurkovic -- Trophoblast disease / Philip Savage and Michael Seckl -- Prenatal diagnosis and genetics / Sailesh Kumar -- Fetal medicine in clinical practice / R.C. Wimalasundera -- Obstetric emergencies / Sara Paterson-Brown -- Disorders of fetal growth and assessment of fetal well-being / G.C.S. Smith and C.C. Lees -- Multiple pregnancy / Nicholas M. Fisk -- Preterm labour / Philip Bennett -- Prolonged pregnancy / Patricia Crowley -- Induction and augmentation of labour / G. Justus Hofmeyr -- Malpresentation, malposition, cephalopelvic disproportion and obstetric procedures / S. Arulkumaran -- Hypertensive disorders / Andrew Shennan -- Heart disease in pregnancy / Catherine Nelson-Piercy -- Diabetes and endocrine disease in pregnancy / Anne Dornhorst and Catherine Williamson -- Renal disease / John Davison -- Haematological problems in pregnancy / P. Clark, A.J. Thomson and I.A. Greer -- Miscellaneous medical disorders / Andrew McCarthy -- Obstetric statistics / Jim G. Thornton -- Contraception / Anna Glasier -- Termination of pregnancy / Gillian Flett and Allen Templeton -- Normal and abnormal development of the genital tract / D. Keith Edmonds -- The menstrual cycle / William L. Ledger -- The role of ultrasound in gynaecology / Joanne Topping -- Gynaecological disorders of childhood and adolescence / D. Keith Edmonds -- Primary amenorrhoea / D. Keith Edmonds -- Polycystic ovarian syndrome and secondary amenorrhoea / Adam H. Balen -- Menstrual problems: menorrhagia and primary dysmenorrhoea / Margaret C.P. Rees -- Premenstrual syndrome / P.M.S. O'Brien -- Pelvic infection / Jonathan D.C. Ross and Peter Stewart -- Chronic pelvic pain / R. William Stones -- Endometriosis / Stephen Kennedy and Philippe Koninckx -- Infertility / Siladitya Bhattacharya -- Assisted reproduction / Geoffrey Trew -- Menopause and the postmenopausal woman / Nick Panay -- Pelvic floor dysfunction I: uterovaginal prolapse / Anthony R.B. Smith -- Urninary incontinence / D. Robinson and L. Cardozo -- Hysteroscopy and laparoscopy / Adam Magos -- Benign disease of the vulva / Richard Staughton -- Malignant disease of the vulva and vagina / David M. Luesley -- Benign diseases of the vagina, cervix and ovary / D. Keith Edmonds -- Premalignant and malignant disease of the cervix / Mahmood I. Shafi -- Epithelial ovarian cancer / Hani Gabra -- Benign disease of the uterus / Mary Ann Lumsden -- Cancer of the uterine corpus / Henry C. Kitchener -- Sexual dysfunction / Fran Reader -- Ethical dilemmas in obstetrics and gynaecology / Gordon M. Stirrat -- The law and the obstetrician and gynaecologist / Bertie Leigh -- Domestic violence and sexual assault / Maureen Dalton.
  • "Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study."--Publisher's description.
  • Also available: Print – 2005
    Print Material
  • Also available: Print – 2012
  • 1. C-Peptide and Insulin: A Happy Marriage / Donald F. Steiner -- 2. Peptide Interactions of Proinsulin C-Peptide / Charlotte Nerelius, Emma Lindahl, Michael Landreh, and Hans Jörnvall -- 3. The Effect of Combined C-Peptide and Zinc on Cellular Function / Dana M. Spence -- 4. C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy / Nigel J. Brunskill -- 5. Role of C-Peptide in the Regulation of Microvascular Blood Flow / Thomas Forst, Matthias M. Weber, Thomas Kunt, and Andreas Pfützner -- 6. Is NO-eNOS a Target for C-Peptide Action and Its Protective Effects on Diabetic Nephropathy? / Kazuhiro Kimura and Akihiro Kamikawa -- 7. Renoprotective Effects of C-Peptide on Type 1 Diabetes / Lina Nordquist, Åsa Kallas, Sara Stridh, Fredrik Palm, and John Wahren -- 8. The Mechanisms Underlying the Effects of C-Peptideon Type 1 Diabetic Neuropathy / Hideki Kamiya, Wei-Xian Zhang, and Anders A.F. Sima -- 9. C-Peptide and Type 1 Diabetic Encephalopathy / Anders A.F. Sima and Wei-Xian Zhang -- 10. C-Peptide: A New Moleculewith Anti-Inflammatory Properties / Jaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, and Patrizia Luppi -- 11. C-Peptide: Connecting Diabetes with Macrovascular Complications / Karen E. Porter and Romana S. Mughal -- 12. C-Peptide and Diabetic Neuropathy in Patients with Type 1 Diabetes / Karin Ekberg and John Wahren -- 13. Proatherogenic Effects of C-Peptide / Daniel Walcher and Nikolaus Marx -- 14. Conclusions and Future Outlook / Anders A.F. Sima.
  • Targeting type 2 diabetes -- Dual acting and pan-PPAR activators as potential anti-diabetic therapies -- GLP-1 agonists and dipeptidyl-peptidase IV inhibitors -- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes -- SGLT inhibitors as new therapeutic tools in the treatment of diabetes -- Inhibitors of 11[beta]-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy -- Nampt and its potential role in inflammation and type 2 diabetes -- Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance -- Overcoming insulin resistance with ciliary neurotrophic factor -- Thermogenesis and related metabolic targets in anti-diabetic therapy -- Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes -- Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes -- AMP-activated protein kinase and metabolic control -- Mitochondria as potential targets in antidiabetic therapy -- Research and development of glucokinase activators for diabetes therapy : theoretical and practical aspects.
  • This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors, and available drug therapies. Appropriate myocardial revascularization strategies are explained, and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented, and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.
  • 1. Effects of insulin on the vascular system / Helmut O. Steinberg -- 2. Effects of diabetes and insulin resistance on endothelial functions / Zhiheng He, Keiko Naruse, and George L. King -- 3. Diabetes and advanced glycoxidation end-products / Melpomeni Peppa, Jaime Uribarri, and Helen Vlassara -- 4. The renin-angiotensin system in diabetic cardiovascular complications / Edward P. Feener -- 5. PPARs and their emerging role in vascular biology, inflammation, and atherosclerosis / Jorge Plutzky -- 6. Diabetes and thrombosis / David J. Schneider and Burton E. sobel -- 7. Role of estrogens in vascular disease in diabetes: lessons learned from the polycystic ovary syndrome / Agathocles Tsatsoulis and Panayiotic Economides -- 8. Poly(ADP-ribose) polymerase activation and nitrosative stress in the development of cardiovascular disease in diabetes / Pál Pacher and Csaba Szabó -- 9. Adiponectin and the cardiovascular system / Suketu Shah, Alina Gavrila, and Christos S. Mantzoros -- 10. Nitric oxide and its role in diabetes mellitus / Michael T. Johnstone and Eli Gelfand -- 11. Diabetes and atherosclerosis / Maria F. Lopes-Virella and Gabriel Virella -- 12. The use of animal models to study diabetes and atherosclerosis and potential anti-atherosclerotic therapies / Peter D. Reaven and Wulf Palinski -- 13. The metabolic syndrome and vascular disease / S.J. Creely, Aresh J. Anwar, and Sudhesh Kumar -- 14. Diabetes and hypertension / Samy I. McFarlane ... [et al.] -- 15. Diabetes and dyslipidemia / Asha Thomas-Geevarghese, Catherine Tuck, and Henry N. Ginsberg -- 16. Diabetic retinopathy / Lloyd Paul Aiello and Jerry Cavallerano -- 17. Diabetic nephropathy / Richard J. Solomon and Bijan Roshan -- 18. Diabetic neuropathy / Rayaz A. Malik and Aristidis Veves -- 19. Microcirculation of the diabetic foot / Chantel Hile and Aristidis Veves -- 20. Epidemiology of peripheral vascular disease / Stephanie G. Wheeler, Nicholas L. Smith, and Edward J. Boyko -- 21. Noninvasive methods in assess vascular function and pathophysiology / Peter G. Danias and Rola Saouaf -- 22. Peripheral vascular disease in patients with diabetes mellitus / Bernadette Aulivola, Allen D. Hamdan, and Frank W. LoGerfo -- 23. Therapeutic interventions to improve endothelial function in diabetes / Lalita Khaodhiar and Aristidis Veves -- 24. Preoperative assessment and perioperative management of the surgical patient with diabetes mellitus / Alanna Coolong and Mylan C. Cohen -- 25. Diabetes and percutaneous interventional therapy / David P. Oorenz, Joseph P. Carrozza, and Lawrence Garcia -- 26. Cardiac surgery and diabetes mellitus / Tanveer A. Khan, Pierre Voisine, and Frank W. Sellke -- 27. Heart failure and cardiac dysfunction in diabetes / Lawrence H. Young, Raymond R. Russell, III, and Deborah Chyun -- 28. Diabetes mellitus and heart disease / Michael T. Johnstone and George P. Kinzfogl.
  • Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
  • "Diabetes and Kidney Disease reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease."--Publisher's website.
  • In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.
  • The relationship between exercise, nutrition, and type 2 diabetes / Stephenson, E.J., Smiles, W., Hawley, J.A. -- Sedentary behavior as a mediator of type 2 diabetes / Hamilton, M.T., Hamilton, D.G., Zderic, T.W. -- Increasing prevalence of type 2 diabetes in sub-Saharan Africa : not only a case of inadequate physical activity / Ojuka, E., Goyaram, V. -- Exercise interventions to prevent and manage type 2 diabetes : physiological mechanisms / Dela, F., Prats, C., Helge, J.W. -- Relationships between exercise, mitochondrial biogenesis, and type 2 diabetes / Joseph, A.-M., Hood, D.A. -- Interaction between lipid availability, endurance exercise, and insulin sensitivity / Newsom, S.A., Schenk, S. -- Mechanisms in exercise-induced increase in glucose disposal in skeletal muscle / Ojuka, E., Goyaram, V. -- The effect of exercise on obesity, body fat distribution and risk for type 2 diabetes / Goedecke, J.H., Micklesfield, L.K. -- Gene-physical activity interactions and their impact on diabetes / Kilpelinen, T.O., Franks, P.W. -- Physical activity and gestational diabetes mellitus / van Poppel, M.N.M., Ruchat, S.-M., Mottola, M.F. -- Physical activity in children : prevention of obesity and type 2 diabetes / Rush, E., Simmons, D. -- Diabetes and exercise in the elderly / Ferriolli, E., Pinheiro Amador S., Pessanha, F., Lemos S. Marchesi, J.C. -- Public health recommendations for physical activity in the prevention of type 2 diabetes mellitus / Lambert, E.V., Bull, F. -- Exercise for people with type 1 diabetes / Gallen, I.W.
  • This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.
  • Diabetes, in all of its forms, now constitutes a growing health concern, affecting all segments of the world's population. There is great interest in the factors which influence its etiology and progression. Among these, a number of viruses feature prominently. Hindered by technological limitations, research into this relationship has hitherto been scarce. Recent advances, however, have opened up the field and there is a burgeoning body of literature on the subject. Unfortunately, this literature has been diffuse and often difficult to access.For the first time, this book compiles the views of many of the world's experts in the field. It addresses questions, ranging from how viruses may destroy or modify the function of pancreatic islets; to which viruses are the most likely culprits; to whether vaccines or etiologic therapies might be used to prevent virus-induced diabetes. Diabetes and Viruses is the first comprehensive volume on an important and expanding field of research that is of interest to clinicians, healthcare managers, epidemiologists, veterinarians, and basic scientists.
  • The Epidemiology of Diabetes in Older People -- Type 2 Diabetes and Dementia -- Depression in Older People with Diabetes -- Hypoglycaemia and the Older Person -- Cardiovascular Risk, Glucose and Targets for Management of Diabetes in Older People -- Diabetes and Frailty -- Perceptions of Users and Carers in Supporting Diabetes Care: Practical Guidance, Support and Information for Carers -- Management of Elderly People with Diabetes in Primary Care.
  • Definition and epidemiology of type 2 diabetes mellitus -- Insulin resistance : pathophysiology, molecular mechanisms, genetic insights -- Type 1 diabetes : pathophysiology, molecular mechanisms, genetic insights -- The metabolic syndrome : prevalence and controversies in clinical context -- Lifestyle interventions for the prevention of type 2 diabetes mellitus -- Pharmacologic and surgical interventions that prevent or worsen type 2 diabetes -- Epidemiology of coronary and peripheral atherosclerosis in diabetes -- Pathology of diabetic atherosclerosis : composition, characteristics, and distribution -- Vascular biology of atherosclerosis in patients with diabetes : hyperglycemia, insulin resistance, and hyperinsulinemia -- Vascular biology of atherosclerosis in patients with diabetes : dyslipidemia, hypercoagulability, endothelial dysfunction, and inflammation -- Type 1 diabetes and associated cardiovascular risk and disease -- Effect of lifestyle interventions on coronary heart disease risk in patients with diabetes -- Effect of glucose management on coronary heart disease risk in patients with diabetes -- Effect of blood pressure management on coronary heart disease risk in patients with type 2 diabetes -- Effect of lipid management on coronary heart disease risk in patients with diabetes -- Effect of antiplatelet therapy on coronary heart disease risk in patients with diabetes mellitus -- Role of percutaneous coronary intervention in patients with diabetes -- Role of coronary artery bypass surgery in diabetes and perioperative glucose management -- Epidemiology of acute coronary syndromes in patients with diabetes -- Hyperglycemia and acute coronary syndromes : association with outcomes and management -- Antiplatelet and antithrombotic therapy in diabetic patients with acute coronary syndrome -- Role of primary invasive strategy and revascularization in diabetic patients with acute coronary syndromes -- Epidemiology of heart failure in diabetes -- Diabetic cardiomyopathy : mediators and mechanisms -- Prevention of heart failure in patients with diabetes -- Treatment of heart failure in diabetes : systolic dysfunction, diastolic dysfunction, and post-acute coronary syndrome -- Peripheral artery disease in diabetes -- Cerebrovascular disease in patients with diabetes -- Cardiovascular autonomic neuropathy -- Disparities in diabetes risk, cardiovascular consequences, and care : women, ethnic minorities, and the elderly -- The quality chasm : diabetes mellitus.
  • Etiopathogenetic aspects of type 1 diabetes / Knip, M. -- Susceptibility to type 1 diabetes: genes and mechanisms / Contu, D., Cucca, F. -- Autoimmunity in type 1 diabetes mellitus / Achenbach, P., Ziegler, A.G. -- Neonatal diabetes mellitus / Polak, M., Shield, J. -- Diagnosis and management of MODY in a pediatric setting / Njolstad, P.R., Sovik, O. -- Diabetic ketoacidosis / Brink, S.R. -- Insulin treatment / Kapellen, T.M. -- Medical nutrition therapy of children and adolescents with diabetes / Virtanen, S.M. -- Continuous subcutaneous insulin infusion in childhood and adolescence / Phillip, M., Weintrob, N., Shalitin, S. -- Quality management in pediatric diabetology / Holl, R.W. ... [et al.] -- Sports and physical activity in children and adolescents with type 1 diabetes mellitus / Raile, K. ... [et al.] -- Invasive and noninvasive means of diabetes self-management / Deiss, D., Hartmann, R., Kordonouri, O. -- Adolescence / Dunger, D.B., Acerini, C., Ahmed, M.L. -- Diabetic nephropathy in children and adolescents / Chiarelli, F., Santilli, F. -- Diabetic autonomic and peripheral neuropathy / Donaghue, K.C., Al-Jasser, A., Maguire, A. -- Macrovascular disease / Dahl-Jørgensen, K., Larsen, J.R. -- Hypoglycemia in children and adolescents with type 1 diabetes / Blasetti, A. ... [et al.] -- Diabetic retinopathy in children and adolescents with type 1 diabetes / Bittner, C., Kordonouri, O., Danne, T. -- Complications and consequences / Kapellen, T.M., Klemens, A.G., Kiess, R.W. -- Type 2 diabetes mellitus in childhood / Piscopo, M.A. ... [et al.] -- Beta-cell function replacement by islet transplantation and gene therapy / Falqui, L.L.
  • Diabetes in women 2009
  • At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primary audience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.
  • Introduction to diabetes -- Diagnosing and managing the metabolic syndrome in adults, children, and adolescents -- Polycystic ovary syndrome -- Managing type 2 diabetes in adults -- Physiologic insulin replacement therapy -- Insulin pump therapy -- Assessing glycemic control using home blood glucose monitoring, continuous glucose sensing, and glycated hemoglobin (A1C) testing -- Management of diabetes in pregnancy, childhood, and adolescence -- Lifestyle interventions for patients with diabetes -- In-patient management of patients with diabetes -- Screening, diagnosis, and management of diabetes-related complications -- Amylin, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase IV (DPP-IV) inhibitors as novel treatments for diabetes -- Managing mental illness in patients with diabetes.
  • Introduction to diabetes -- Prediabetes -- Lifestyle interventions for patients with diabetes -- Polycystic ovary syndrome -- Prevention, diagnosis, and treatment of microvascular complications: Part 1, diabetic neuropathy -- Prevention, diagnosis and treatment of microvascular complications: Part 2, diabetic nephropathy and diabetic retinopathy -- Exploring the association between diabetes and cardiovascular disease -- Associated disorders of interest to primary care -- Co-managing mental illness in patients with diabetes -- Diagnosis and management of T2DM -- Type 1 diabetes mellitus in adults -- Insulin initiation and intensification for patients with type 2 diabetes -- Insulin pumping and use of continuous glucose sensors in primary care -- Addressing cultural competency in diabetes care.
  • Diabetes and health care: an overview / M. Abhilash and Robin Augustine -- Withania coagulans Dunal: an overview on its up to date antidiabetic investigations / S. Hemalatha, Satyendra K. Prasad, Manish Kumar, and S. D. Dubey -- Evaluation of total phenolics and free radical quenching activity of Glycosmis pentaphylla (Retz.) A. DC. / Rahul Chandran and Thangaraj Parimelazhagan -- Antioxidant, antidiabetic, and chemical composition of Syzygium aqueum leaf extracts / Uma D. Palanisamy and Thamilvaani Manaharan -- Review on novel 2, 4-thiazolidinedione derivatives as potential therapeutic agents for type II diabetes / Gangadhara Angajala and Radhakrishnan Subashini -- Molecular mechanism of S-oxidation of anti-diabetic thiazolidinedione class of drugs: computational approaches to drug metabolism / Nikhil Taxak and P. V. Bharatam -- Role of wound dressings in the management of chronic and acute diabetic wounds / Robin Augustine, Nandakumar Kalarikkal, and Sabu Thomas -- Recent advances in diabetic foot care: the role of footwear and orthosis / G. Saraswathy, Gautham Gopalakrishna, B. N. Das, and Vijay Viswanathan -- Temporal effect of repeated stress on type-2 experimental diabetes / Debapriya Garabadu and Sairam Krishnamurthy -- Sugar rich diet induced insulin resistance and alteration in gut microflora / Prasant Kumar Jena, Shilpa Singh, and Sriram Seshadri -- Prevalence of diabetes mellitus in patients presenting with acute myocardial infarction / Meeakshi Narkhede, Satyanarayan Durgam, Harshal Bhitkar, Swapnil Yadav, and Dilip Mhaisekar -- Development of therapeutic strategy to restore coronary microcirculation and VEGF signaling cascade in diabetes: a novel approach to prevent cardiac complication in diabetes / Subrina Jesmin, Arifur Rahman, Abdullah Al Mamun, Farzana Sohael, Shamima Akter, Yoshio Iwashima, Nobutake Shimojo, Naoto Yamaguchi, Michiaki Hiroe, Taro Mizutani, and Masao Moroi.
  • Diabetes from growth hormone excess / Neggers, S.J., van der Lely, A.J. -- Diabetes in growth hormone deficiency / Prodam, F., Zavattaro, M., Caputo, M., Marzullo, P., Aimaretti, G. -- Diabetes associated with glucocorticoid excess / Janssen, J.A.M.J.L., Lamberts, S.W. -- Diabetes in hyperaldosteronism / Crudo, V., Mulatero, P., Monticone, S., Veglio, F. -- Diabetes from catecholamine excess / Mannelli, M., Parenti, G., Zampetti, B., Canu, L., Mannucci, E. -- Diabetes and hyperthyroidism / Mitrou, P., Dimitriadis, G., Raptis, S.A. -- Diabetes secondary to neuroendocrine gastroenteropancreatic tumors / Minuto, F., Ferone, D., Boschetti, M., Albertelli, M., Gatto, F. -- Type 2 diabetes in polycystic ovary syndrome / Pasquali, R., Gambineri, A. -- Diabetes in hyperparathyroidism / Thomas, A., Kautzky-Willer, A. -- Posttransplant diabetes / Secchi, A., Scavini, M. -- Diabetes in pancreatitis, pancreatectomy, and other pancreatic diseases / Tiengo, A., Vigili de Kreutzenberg, S., Del Prato, S. -- Fibrocalculous pancreatic diabetes / Unnikrishnan, R., Mohan, V. -- Diabetes and hemochromatosis / Wood, M.J., Gonsalkorala, E.S., Powell, L.W. -- Secondary diabetes : clinical considerations / Ghigo, E., Guaraldi, F., Porta, M.
  • Part I. Metabolic derangements in diabetic cardiomyopathy -- Part II. Cellular mechanisms of diabetic cardiomyopathy -- Part III. Therapeutic aspects of diabetic cardiomyopathy -- Index.
  • Clinical features and diagnosis -- Principles of care in the diabetic surgical patient -- Epidemiology and health care cost of diabetic foot problems -- Diabetic polyneuropathy -- Clinical examination and risk classification of the diabetic foot -- Clinical features and diagnosis of peripheral arterial disease -- Imaging of infection in the diabetic foot -- Pathophysiology -- Physiology and pathophysiology of wound healing in diabetes -- Neuropeptides and diabetic wound-healing -- Induced regeneration of skin and peripheral nerves in the adult -- Microvascular changes in the diabetic foot -- Biomechanics of the diabetic foot: the road to foot ulceration -- Diabetic foot ulcers: effects of hypertoxia and stromal-derived factor-1[alpha] on endothelial progenitor cells -- Management of the diabetic foot -- Wound bed preparation of the diabetic foot ulcer -- Foot pressure abnormalities in the diabetic foot -- Proactive wound care -- Local care of diabetic foot ulcers: assessment, dressings, and topical treatments -- Surgical treatment of the ulcerated foot -- Microbiology and treatment of diabetic foot infections -- Lower extremity arterial reconstruction in patients with diabetes mellitus: principles of treatment -- Charcot arthropathy in the diabetic foot -- Soft tissue reconstruction options for the ulcerated or gangrenous diabetic foot -- Amputations and rehabilitation -- Organization and preventive care -- Organization of the diabetic foot care team -- Quality of health care -- Psychosocial and educational implications of diabetic foot complications -- Role of footwear in the prevention of diabetic foot problems.
  • Introduction to diabetes: principles of care in the surgical patient with diabetes / Peter Sheehan -- Epidemiology and health care costs for diabetic foot problems / Gayle E. Reiber and Lynne V. McFarland -- The evolution of wound healing: from art to science / I. Kelman Cohen -- The wound-healing process / Jeffrey M. Davidson and Luisa DiPietro -- Induced regeneration of skin and peripheral nerves / Eric C. Soller and Ioannis V. Yannas -- Diabetic neuropathy / Solomon Tesfaye -- Microvascular changes in the diabetic foot / Thanh Dinh and Aristidis Veves -- Clinical features and diagnosis of macrovascular disease / Chantel Hile ... [et al.] -- Foot pressure abnormalities in the diabetic foot / Thomas E. Lyons, Barry I. Rosenblum, and Aristidis Veves -- Biomechanics of the diabetic foot: the road to foot ulceration / C.H.M. van Schie and A.J.M. Boulton -- Clinical examination of the diabetic foot and the identification of the at-risk patient / Stephanie Wu ... [et al.] -- Imaging of the diabetic foot / Mary G. Hochman ... [et al.] -- Microbiology and treatment of diabetic foot infections / Adolf W. Karchmer -- Charcot arthropathy in the diabetic foot / Robert G. Frykberg -- Preparation of the wound bed of the diabetic foot ulcer / Vincent Falanga -- Local care of diabetic foot ulcers: assessment, dressings, and topical treatments / Oscar M. Alvarez, Lee Markowitz, and Martin Wendelken -- Surgical treatment of the ulcerated foot / John M. Giurini -- Amputation and rehabilitation of the diabetic foot / Ronald A. Sage ... [et al.] -- Soft tissue reconstructive options for the ulcerated or gangrenous diabetic foot / Christopher E. Attinger -- Role of growth factors in the treatment of diabetic foot ulceration / David L. Steed -- Living skin equivalents for the diabetic foot ulcer / Thanh Dinh and Aristidis Veves -- Lower extremity arterial reconstruction in patients with diabetes mellitus: principles of treatment / Kakra Hughes, David Campbell and Frank B. Pomposelli, Jr. -- Angioplasty and other noninvasive surgical procedures / Sherry D. Scovell -- Psychosocial and educational implications of diabetic foot complications / Katie Weinger and Arlene Smaldone -- The role of footwear in the prevention of diabetic foot problems / Luigi Uccioli.
  • Diabetic kidney 2006
    Angiotensin II and its receptors in the pathogensis of diabetic nephropathy / David J. Leehey, Ashok K. Singh, and Rekha Singh -- Altered renal microvasculature function in early diabetes / Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii -- Proteinuria and interstitial fibrogenesis in diabetic nephropathy / Raimund Hirschberg -- Podocytes and diabetic nephropathy / George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac -- Altered glucose transport and its metabolic effects in glomerular cells / Charles W. Heilig -- mRNA translation in diabetic nephropathy / Balakuntalam S. Kasinath ... [et al.] -- The hexosamine biosynthesis pathway: contribution to the pathogenesis of diabetic nephropathy / I. George Fantus ... [et al.] -- Glycation: receptor for advanced glycation endproducts and diabetic nephropathy / Vivette D'Agati and Ann Marie Schmidt -- Oxidative and glycooxidative stress in diabetic nephropathy / Frederick R. DeRubertis and Patricia A. Craven -- Connective tissue growth factor in the pathogenesis of diabetic nephropathy: a target for therapeutic intervention / Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor -- Vascular endothelial growth factor as a determinant of diabetic nephropathy / Geoffrey Boner and Mark E. Cooper -- Transforming growth factor-[beta] signal transduction in the pathogenesis of diabetic nephropathy: identifying molecular targets for therapeutic intervention / Sheldon Chen and Fuad N. Ziyadeh -- Hepatocyte growth factor: physiological and therapeutic ligand to attenuate diabetic nephropathy / Shinya Mizuno and Toshikazu Nakamura -- Proteomics in the investigation of diabetic nephropathy / Visith Thongboonkerd -- Gene expression profiling in the investigation of diabetic nephropathy / Katalin Susztak, Erwin Bottinger, and Kumar Sharma -- PPAR- ligands and diabetic nephropathy / Keiji Isshiki, Daisuke Koya, and Masakazu Haneda -- -Endosulfine in diabetic nephropathy / Jerry Yee and Balazs Szamosfalvi -- The prospect of a novel therapeutic, bone morphogenetic protein-7, in diabetic nephropathy / Keith A. Hruska ... [et al.] -- Genetic determinants of diabetic nephropathy in type 2 diabetes / Grzegorz Placha and Andrzej S. Krolewski -- Major risk indicators for diabetic kidney disease / Katherine R. Tuttle -- The structure of human diabetic nephropathy / Michael Mauer and Behzad Najafian -- Diabetic kidney disease in transitional and disadvantaged populations / E. Jennifer Weil and Robert G. Nelson -- Screening and treatment of early diabetic renal disease in type 1 and type 2 diabetes / Ellie Chuang and Mark E. Molitch -- Treatment in advanced renal disease in type 1 and type 2 diabetes / Eberhard Ritz and Gunter Wolf -- Diabetic and renal disease: ACE inhibitors and/or angiotensin receptor blockers: does it matter? / Carl Erik Mogensen and Niels Holmark Andersen -- Management of diabetic end-stage renal disease with dialysis / Ploumis S. Passadakis and Dimitrios G. Oreopoulos -- Diabetic retinopathy and nephropathy / Ronald Klein -- Hypertension and cardiovascular disease / Adam Whaley-Connell, Kurt Sowers, and James R. Sowers -- Endothelial dysfunction and diabetic nephropathy / Coen D.A. Stehouwer ... [et al.] -- Anemia and diabetic nephropathy / George Jerums ... [et al.].
  • Historical aspects of diabetic neuropathies -- The epidemiology of diabetic neuropathy -- Genomics of diabetic neuropathy -- Transgenic and gene knockout analysis -- Hyperglycemia-initiated mechanisms in diabetic neuorpathy -- Effectors-sonic hedgehog and p38 mitogen-activated protein kinase -- Neuronal and Schwann cell death in diabetic neuropathy -- Metabolic-functional-structural correlations in somatic neuropathies in the spontaneously type 1 and type 2 diabetic BB-rats -- Experimental diabetic autonomic neuropathy -- Spinal cord: structure and function in diabetes -- Diabetic encephalopathy -- Microangiopathy, diabetes -- Pathogenesis of human diabetic neuropathy -- Clinical features of diabetic polyneuropathy -- Micro- and macrovascular disease in diabetic neuropathy -- Clinical diagnosis of diabetic neuropathy -- Punch skin biopsy in diabetic neuropathy -- Aldose reductase inhibitors for the treatment of diabetic neuropathy -- Other therapeutic agents for the treatment of diabetic neuropathy -- Pathophysiology of neuropathic pain -- Treatment of painful diabetic neuropathy -- Focal and multifocal diabetic neuropathy -- Hypoglycemia and the autonomic nervous system -- Cardiovascular autonomic neuropathy -- Postural hypotension and anhidrosis -- Gastrointestinal syndromes due to diabetes mellitus -- Genitourinary complications -- Management of diabetic foot complications.
  • 1 Nonproliferative diabetic retinopathy -- 2 Proliferative diabetic retinopathy -- 3 The epidemiology of diabetic retinopathy -- 4 Diagnostic modalities in diabetic retinopathy -- 5 In vivo models of diabetic retinopathy -- 6 The polyol pathway and diabetic retinopathy -- 7 The role of advanced glycation in diabetic retinopathy -- 8 The role of protein kinase C in diabetic retinopathy -- 9 Oxidative stress in diabetic retinopathy -- 10 Pericyte loss in the diabetic retina -- 11 Capillary dropout in diabetic retinopathy -- 12 Neuroglial dysfunction in the pathophysiology of diabetic retinopathy -- 13 The role of inflammation in the pathophysiology of diabetic retinopathy -- 14 Vascular permeability in diabetic retinopathy -- 15 Retinal neovascularization and the role of VEGF -- 16 Beyond VEGF: other factors important in retinal neovascularization: potential targets in proliferative diabetic retinopathy -- 17 Anti-VEGF therapy as an emerging treatment for diabetic retinopathy -- 18 Clinical trials in protein kinase C-Beta inhibition in diabetic retinopathy -- 19 The role of intravitreal steroids in the management of diabetic retinopathy -- 20 Antagonism of the growth hormone axis as a therapeutic strategy for diabetic retinopathy -- 21 Diabetic retinopathy and systemic complications.
  • Also available: Print – 2007
    Pathophysiology of diabetic macular edema / A.M. Joussen, N. Smyth, C. Niessen -- Characterization and relevance of different diabetic retinopathy phenotypes / J. Cunha-Vaz -- Optical coherence tomography findings in diabetic retinopathy / G.E. Lang -- Laser treatment of diabetic retinopathy / G.E. Lang -- Benefits and limitations in vitreoretinal surgery for proliferative diabetic retinopathy and macular edema / A.M. Joussen, S. Joeres, B. Kirchhof -- Diffuse diabetic macular edema: pathology and implications for surgery / A. Gandorfer -- Intravitreal triamcinolone acetonide for diabetic retinopathy / J.B. Jonas -- Use of long-acting somatostatin analogue treatment in diabetic retinopathy / B.O. Boehm -- Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (Macugenr) in diabetic retinopathy / C. Starita ... [et al.] -- Pharmacologic vitreolysis / A. Gandorfer -- Treatment of diabetic retinopathy with protein kinase C subtype [alpha] inhibitor / G.E. Lang.
  • Print Material
    Epidemiology -- Pathophysiology of diabetes -- National clinical trials and classification -- Diagnostic testing -- Examination of the diabetic patient -- New treatment modalities -- Management of nonproliferative diabetic retinopathy -- Management of clinically significant macular edema or diabetic macular edema -- Management of proliferative diabetic retinopathy -- Indications for vitrectomy -- Diabetes in pregnancy -- Complications -- Diabetes and glaucoma -- Informed consent -- Guidelines for nursing staff and medical assistants.
  • Epidemiology of pregestational and gestational diabetes / I. Pavliʹc-Renar, Z̆. Metelko -- Fuel-mediated 'functional teratogenesis' and primary prevention / A. Plagemann -- Endocrine changes in diabetic pregnancy / A. Kautzky-Willer, D. Bancher-Todesca -- Metabolic changes in diabetic pregnancy / E. Herrera -- Leptin in the diabetic pregnancy / S. Hauguet-De Mouzon, J. Lepercq, P. Catalano -- Maternal diabetes and embryonic development / R. De Hertogh -- Normal and abnormal fetal growth / I. Cetin, T. Radaelli -- Effect of nutrition on fetal development: a view on the pancreatic [beta]-cells / B. Blondeau, B. Breant -- The human placenta in diabetes / G. Desoye, P. Kaufmann -- Vasculogenesis and angiogenesis in the diabetic placenta / L. Leach, T.M. Mayhew -- Morphological findings in infants and placentas of diabetic mothers / M. Kos, M. Vogel -- Principles of evidence-based medicine: the lesson for diabetic pregnancy / T.R. Pieber -- The Graz approach to diabetes in pregnancy / P.A.M. Weiss, G. Desoye -- Clinical management of pregnancies complicated with type 1/type 2 diabetes mellitus / J. Djelmis̆ -- Nutritional management of diabetes in pregnancy / A. Dornhorst, G. Frost -- Diabetes-related antibodies and pregnancy / R. Corcoy, D. Mauricio, A. De Leiva -- Insulin and oral hypoglycemic agents in pregnancy / Z̆. Metelko, I. Pavliʹc-Renar -- Continuous glucose monitoring for the evaluation and improved treatment adjustment in gravid women with diabetic pregnancy / M. Hod, Y. Yogev -- Fetal hypoxia and its monitoring in pregestational diabetic pregnancies / K.A. Teramo, V.K. Hiilesmaa -- Ultrasonic surveillance of the diabetic fetus / M. Ivanis̆eviʹc -- Diabetic pregnancy: maternal metabolic and microvascular issues in type 1 diabetes mellitus / D.W.M. Pearson -- Pre-eclampsia in women with type 1 diabetes / E.R. Mathiesen and P. Damm -- Management of delivery / V.A. Miller, M.D.G. Gillmer -- Offspring of diabetic pregnancy / B. Persson, U.J. Eriksson, U. Hanson -- Long-term consequences of gestational diabetes mellitus / J. Lauenborg, E.R. Mathiesen, P. Damm.
  • Print Material
    Mackowiak traces the history of medicine through the illnesses of some of the most influential figures of the past. The diseases suffered by these figures had profound effects on their lives and their legacies.
  • This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-invasive modalities and presents algorithms to optimize and maximize sample collection and processing beginning at the time of tissue acquisition during the procedure. Secondly, the book provides an overview of the various existing and emerging lung cancer therapies and why a specific diagnosis is crucial. Key elements for the classification of small biopsies and cytology proposed by the ATS, IASLC, and ERS are highlighted. A section dedicated to immunohistochemistry offers a logical, step-by-step guide to sub-classify lung cancers and to differentiate them from metastases. The text also provides a review of the various molecular tests (and alternatives in cases of scant tissue) required for lung adenocarcinomas. Finally, potential pitfalls to avoid during acquisition, processing, and classification are discussed. With contributions from a team of multidisciplinary authors who are regularly involved in the care of lung cancer patients , Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology is an invaluable reference guide for pathologists, pathologists-in-training, and allied professionals, including oncologists, pulmonologists, surgeons, and radiologists.
  • A practical, one-stop resource designed to help you manage the unique challenges of treating long-term adult survivors of congenital heart disease. Authored by internationally known leaders in the field, this edition is the first that truly integrates anatomy and imaging technology into clinical practice, and includes new chapters on cardiac CT for ACHD assessment, critical and perioperative care, anesthesia for ACHD surgery, cardiac resynchronization therapy, and transition of care. Congenital defects are presented with high-quality illustrations and appropriate imaging modalities. See imaging findings as they appear in practice and discern subtle nuances thanks to new, high-quality images and illustrations.
  • Citations include changes during past decades in the prevalence, distribution, and progression of dental caries have implications for diagnosis, treatment, prediction of risk, and prevention in individuals or populations. Traditional approaches for treating carious lesions in a surgical manner are being replaced by newer strategies that emphasize disease prevention and conservation. Citations for this bibliography were gathered from journal articles and conference papers written primarily in English and including both human and animal studies.
  • Health Care Organization and its Impact on Care of Diseases of the Hip -- Prevalence and Societal Burden of Hip Osteoarthritis -- Metabolic Syndrome, Obesity, and Osteoarthritis -- Biomechanical Considerations in Arthritis of the Hip -- Gait Pathomechanics in Hip Disease -- Femoroacetabular Impingement -- Osteonecrosis -- Osteoporosis and Hip Fractures -- Preoperative Management of Paget's Disease -- Metabolic Bone Disease Following Organ Transplantation -- Options for Primary Hip Arthroplasty -- Hip Sepsis and the Prevention of Perioperative Infections -- Venous Thromboembolism in Total Hip Arthroplasty.
  • Part I. The syndrome. 1. Clinical manifestations of PCOS / Pasquali Renato --2. The Menstrual cycle in PCOS / Sabrina Gill and Janet E. Hall -- 3. The Radiology of Polycystic ovaries / Susan J. Barter -- Part II. Origins -- 4. Insulin resistance in PCOS / Evanthia Diamanti-Kandarakis and Charikleia D. Christakou -- 5. Genetics of metabolic syndrome and genetic lipodystrophies / Tisha R. Joy and Robert A. Hegele -- 6. The Genetics of polycystic ovary syndrome / Brad Eilerman, Marzieh Salehi, and Yaron Tomer -- 7. Uterine origins and evolution in childhood / Agathocles Tsatsoulis and Nectaria Xita -- Part III. Consequences -- 8. Hyperandrogenism in PCOS / Neoklis A. Georgopoulos, Eleni Kandaraki, and Dimitrios Panidis -- 9. The Risk of diabetes and metabolic syndrome in PCOS / Thomas M. Barber -- 10. The Risks of cardiovascular disease and diabetes in the Polycystic ovary syndrome / Susmeeta T. Sharma and John E. Nestler -- 11. Pregnancy complications in PCOS / Roy Homburg -- 12. Polycystic ovary syndrome, sleep apnea, and daytime sleepiness and fatigue / Alexandros N. Vgontzas and Susan Calhoun -- 13. Polycystic ovarian syndrome and gynaecological cancer / Alexandra Lawrence and W. Peter Mason -- 14. PCOS, depression, and Alzheimer's disease / Pascale G. Stemmle, Heather A. Kenna, and Natalie L. Rasgon -- 15. Psychological issues and their treatment / Melissa J. Himelein and Samuel S. Thatcher -- Part IV. Management -- 16. Dietary management of PCOS / Kate Marsh -- 17. Exercise in the treatment of PCOS / Emma Stevenson -- 18. Medical treatment / Jean-Patrice Baillargeon and Nadir R. Farid -- 19. Therapy of hirsutism / Salvatore Benvenga -- 20. Ovulation induction in PCOS / Evert J.P. van Santbrink -- 21. IVF in Polycystic ovary syndrome / Rehan Salim and Paul Serhal -- 22. The Surgical management of Polycystic ovarian syndrome / Colin J. Davis -- 23. When periods stop: long-term consequences of PCOS / Enrico Carmina, Ettore Guastella, and Manfredi Rizzo.
  • The Pulmonary Circulation -- Epidemiology and Disease Classification of Pulmonary Hypertension -- Pathogenesis of Pulmonary Arterial Hypertension -- Hypoxic Pulmonary Hypertension -- Pulmonary Hypertension In Chronic Heart And Lung Disease -- Chronic Thromboembolic Pulmonary Hypertension -- Schistosomiasis- Associated Pulmonary Arterial Hypertension -- Approach to the Patient with Elevated Pulmonary Arterial Pressure -- Echocardiography -- Pulmonary Hemodynamics and Right Heart Catheterization -- Cardiopulmonary Exercise Testing in Pulmonary Hypertension -- Adjunct Therapy and Calcium Channel Blockers -- Prostacyclin Therapy for Pulmonary Arterial Hypertension -- Endothelin Receptor Antagonists.-Modulation Of cGMP Synthesis And Metabolism -- Combination Therapy for the Treatment of Pulmonary Arterial Hypertension -- Investigative Therapies in Pulmonary Arterial Hypertension -- Pulmonary Hypertension In Critically Ill Patients -- Perioperative Management of Pulmonary Hypertension.
  • This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio-oncologists, pathologists, and basic scientists. The remainder of the book focuses on areas of controversy in the diagnosis, treatment, and follow-up of testicular cancer. In each case the evidence base is discussed and results from the most recent studies are reviewed, drawing attention to new findings that might alter treatment recommendations. The treatment-related chapters cover a broad range of issues, including the best approach in patients with poor-prognosis and recurrent disease and those with long-term toxicities. Relevant aspects of survivorship care are also addressed. The book will help clinicians and practitioners to achieve the goals of minimizing therapy and its side-effects without reducing efficacy in low stage disease, improving the cure rate in advanced disease, and enhancing follow-up and long-term survivorship.
  • Part One Approach to Patients -- Chapter 1 Approach to Patients with Suspected Fungal Infections -- Part Two Laboratory and Radiological Diagnosis -- Chapter 2 Basic Mycology -- Chapter 3 Diagnostic Molecular Biology -- Chapter 4 Diagnostic Histopathology -- Chapter 5 Diagnostic Immunology -- Chapter 6 Diagnostic Radiology -- Part Three Antifungal Agents -- Chapter 7 Antifungal Agents -- Part Four Mycoses -- Chapter 8 Candidiasis -- Chapter 9 Infection Due to non-Candidal Yeasts -- Chapter 10 Aspergillosis -- Chapter 11 Hyalohyphomycosis -- Infection Due to Hyaline Moulds -- Chapter 12 Phaeohyphomycosis -- Infection Due to Dark (Dematiaceous) Moulds -- Chapter 13 Mucormycosis (Zygomycosis) -- Chapter 14 Pneumocystosis -- Chapter 15 Cryptococcosis -- Chapter 16 Blastomycosis -- Chapter 17 Coccidioidomycosis -- Chapter 18 Histoplasmosis -- Chapter 19 Paracoccidioidomycosis -- Chapter 20 Sporotrichosis -- Chapter 21 Dermatophytosis (Tinea) and Other Superficial Fungal Infections -- Chapter 22 Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Entomophthoramycosis and Lacaziosis) -- Part Five Instructive Cases. Instructive Cases -- Instructive Cases Discussion.
  • Part I. Approach to patients. Approach to patients with suspected fungal infections / Clinton K. Murray and Duane R. Hospenthal -- Part II. Laboratory and radiological diagnosis. Basic mycology / Deanna A. Sutton -- Diagnostic histopathology / Michael B. Smith and Michael R. McGinnis -- Diagnostic immunology / Samit S. Desai and Brian Wong -- Diagnostic radiology / Maria Angela C. Hospenthal and Constanza J. Gutierrez -- Part III. Antifungal agents. Antifungal agents / Russel E. Lewis and Annette W. Fothergill -- Part IV. Mycoses. Cadidiasis / Jack D. Sobel -- Infection due to non-candidal yeasts /Jose A. Vazquez -- Aspergillosis / Helen W. Boucher and Thomas F. Patterson -- Hyalophomycosis infection due to hyaline moulds / Rhonda V. Fleming and Elias J. Anaissie -- Phaeohyphomycosis infection due to dark (dematiaceous) moulds / Sanjay G. Revankar -- Zygomycosis (mucormycosis) / Charalampos Antachopoulos, Juan C. Gea-Banacloche, and Thomas J. Walsh -- Pneumocystosis / Francis Gigliotti and Terry W. Wright -- Cryptococcosis / Mathee Chayakulkeeree and John R. Perfect -- Blastomycosis / Stanley W. Champan and Donna C. Sullivan -- Coccidioidomycosis / Royce H. Johnson and Chehla Baqi -- Histoplasmosis / L. Joseph Wheat and Nicholas G. Conger -- Paraccocidiodoycosis / Angela Restrepo, Angela M. Tobón, and Carlos A. Agudelo -- Sporotrichosis / Carol A. Kauffman -- Dermatophytosis (tinea) and other superficial fungal infections / Aditya K. Gupta and Elizabeth A. Cooper -- Subcutaneous fungal infections (chromoblastomycossi, mycetoma, and lobomycosis) / Michael B. Smith and Michael R. McGinnis
  • Epidemiology and Etiology of Discogenic Pain: How Big Is the Problem? -- Establishing the Diagnosis of Discogenic Back Pain: An Evidence-Based Algorithmic Approach -- Imaging for Discogenic Pain -- Provocation Discography -- Analgesic Discography -- Discogenic Pain: Intradiscal Therapeutic Injections and Use of Intradiscal Biologic Agents -- Radiofrequency and Other Heat Applications for the Treatment of Discogenic Pain -- Arthrodesis and Fusion for the Treatment of Discogenic Neck and Back Pain: Evidence-Based Effectiveness and Controversies -- Nucleus Pulposus Replacement and Motion-Sparing Technologies -- Cervical and Thoracic Discogenic Pain: Therapeutic Nonsurgical Options -- Disc Herniations: Injections and Minimally Invasive Techniques -- Current Surgical Options for Intervertebral Disc Herniation in the Cervical and Lumbar Spine -- Neuromodulation and Intrathecal Therapies for the Treatment of Chronic Radiculopathy Related to Intractable Discogenic Pain.
  • "A practical approach to the early detection and management of breast cancer. This lavishly illustrated atlas provides radiologists with essential information for the differential diagnosis of breast diseases on the basis of clinical presentation, mammography, and ultrasound. The book begins with chapters on tumor biology, prognostic factors, and histology. The authors then provide a thorough evaluation of various methods for early detection and accurate diagnosis, including analog and digital mammography, ultrasound, MR imaging, PET/CT, and interventional procedures. They discuss in detail the strengths and limitations of each imaging modality, aspects of quality control, test intervals, peri- and postoperative management principles, and follow-up care.Highlights:- Presentation of difficult cases that effectively demonstrate the diagnostic hurdles and forensic pitfalls in breast diagnosis- Special sections on breast cancer in men and young women, with discussion of women who are pregnant or lactating- Color-coded practical tips and clinical notes for optimal comprehension of the material- Extensive Q&A sections for self-testing in two major chapters - More than 1,700 high-quality illustrations, including clinical color photographs, ultrasound images, and mammograms"--Provided by publisher.
  • Print Material
  • Also available: Print – 2005
  • Small Sample Lung Biopsy Techniques in the Diagnosis of Airway and Parenchymal Lung Diseases -- Principles of Imagining Lung Disease -- Types of Biopsies -- Air Space Occupying Diseases -- Interstitial Lung Diseases in Small Lung Biopsies -- Diagnosis of Granulomatous Disease and Vasculitis in Small Lung Biopsies -- Benign Tumors of the Lung in Small Lung Biopsies -- Malignant Tumors of the Lung in Small Lung Biopsies.
  • Also available: Print – 2005
  • Endovascular repair of dialysis fistulas and grafts: strengths and weaknesses -- Role of the nephrologist, interventional radiologist, and vascular access in the treatment of end-Stage renal disease -- Access creation strategy -- Natural history of vascular access -- Radiological anatomy and preoperative imaging of upper limb vessels -- Indications and imaging modalities in dialysis access -- Psychological and clinical issues -- Patient preparation prior to angiography and endovascular interventions -- Angiography (Fistulography) -- Dilation and stent placement -- Hand ischemia -- Treatment of thrombosed accesses -- Therapeutic occlusion of dysfunctional accesses -- Complications during and after vascular access endovascular procedures -- Vascular access intervention outcomes.
  • Also available: Print – 1994
  • Also available: Print – 2013
    Section 1. DSM-5 basics. Introduction -- Use of the manual -- Cautionary statement for forensic use of DSM-5 -- Section 2. Diagnostic criteria and codes. Neurodevelopmental disorders -- Schizophrenia spectrum and other psychotic disorders -- Bipolar and related disorders -- Depressive disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Dissociative disorders -- Somatic symptom and related disorders -- Feeding and eating disorders -- Elimination disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance-related and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Paraphilic disorders -- Other mental disorders -- Medication-induced movement disorders and other adverse effect of medication -- Other conditions that may be a focus of clinical attention -- Section 3. Emerging measures and models. Assessment measures -- Cultural formulation -- Alternative DSM-5 Model for Personality Disorders -- Conditions for further study -- Appendix. Highlights of changes from DSM-IV to DSM-5 -- Glossary of technical terms -- Alphabetic listing of DSM-5 diagnoses and codes (ICD-9-CM and ICD-10-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-9-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-10-CM) -- DSM-5 advisors and other contributors.
  • Also available: Print – 2000
  • Also available: Print – 1987
  • Print Material
  • Print Material
  • Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux. This atlas is a source of easily digestible practical information for pathologists faced with biopsies from this region. It is also aimed at gastroenterologists as they biopsy these patients.
  • Ephelides and Lentigo -- Melanocytic Nevus -- Congenital Nevus -- Spitz and Reed Nevus -- Dysplastic Nevus -- Dermal Melanocytoses -- Melanoma General -- Melanoma Variants -- Oral Mucosa Pigmented Lesions -- Conjunctival Melanocytic Lesions.
  • This 2nd edition by Agnes B. Fogo, MD and Michael Kashgarian, MD, delivers practical, highly visual guidance for effectively and accurately diagnosing a wide range of pathologic entities. More than 700 high-quality illustrations help you to recognize the pathologic features and clinical manifestations of both common and rare renal disorders and to formulate confident and accurate diagnoses. Thoroughly updated throughout, this companion to Brenner & Rector's, The Kidney, 9th Edition provides the newest information regarding categorizing and classification of diseases and describes how this relates to the various morphological lesions illustrated and their clinical significance.
  • "Encompassing the entire spectrum of breast imaging and diagnostics, this acclaimed text provides a systematic and pragmatic guide for all clinicians involved in diagnosing breast disease. The new third edition has been fully updated to include advances in mammography, ultrasound, breast MRI, percutaneous interventions, and emerging technologies, with pros and cons and evidence-based approaches throughout. Special features of the third edition: Coverage of the field, with comprehensive sections on examination procedures and technical requirements; histologic, clinical, and radiologic appearance of a wide range of breast pathologies; results of international screening studies; and much more. Nearly 1,200 clear radiographic images showing normal findings, benign and malignant disorders, and post-traumatic, post-surgical, and post-therapeutic changes to the breast. Innovations in digital mammography, tomosynthesis, and computer assisted detection (CAD); new chapters on imaging of implants, lesions of uncertain malignant potential, developing technologies; and more. A systematic, highly reproducible methodology for detection, diagnosis, and assessment of findings. Easy-to-follow flowcharts for the diagnostic work-up of both typical and atypical cases. Written by world-renowned authorities with decades of clinical experience, this book provides a brilliant orientation to the multimodality diagnostic approach and therapeutic significance of breast imaging findings. It is an essential reference and board review for radiologists, residents and fellows, gynecologists, oncologists, surgeons, technologists, and any other interdisciplinary specialist working to improve outcomes in breast disease"--Provided by publisher.
  • Consensus, disagreement, and diagnostic labels -- Cerebrovascular diseases -- Dementias and behavioral disorders -- Demyelinating disorders -- Disorders of consciousness and brain death -- Epilepsy -- Genetic syndromes -- Headache -- Immune-based disorders -- Infectious diseases -- Movement disorders -- Neuromuscular disorders -- Pain, fatigue, and trauma -- Sleep disorders.
  • Diagnostic Cytopathology Board Review and Self-Assessment provides a comprehensive systems-based review of non-gynecological cytology including cytomorphology, pitfalls and ancillary studies, presented in a high-yield format with board-type multiple choice questions and detailed answers. It provides an excellent review, resource, and self-assessment for pathologists, cytopathologists, and cytotechnologists, as well as trainees (pathology residents, cytopathology fellows, and cytotechology students) who are preparing for board examinations or in-service examinations, in addition to those who are looking to fine-tune their cytology diagnostic skills. The volume is organized in a systems-based format including chapters covering lung, lymph nodes, pancreas, liver, gastrointestinal tract, thyroid, salivary gland, central nervous system, soft tissue and bone, kidney, adrenal, retroperitoneal, and exfoliative cytology of urine, serous fluids, and CSF. This book is enriched with high yield review, board exam-type questions, and high quality full-color images to maximize studying and review of cytopathology.
  • Introduction -- Female genital tract -- Respiratory -- Serous effusions -- Urine cytology -- Thyroid gland -- Haemopoietic -- Breast -- Salivary gland -- Liver, biliary tree and pancreas -- Childhood tumours -- Miscellaneous -- Techniques -- Self-assessment questions.
  • Cytopathology: the history, the present and the future direction -- Respiratory system -- Respiratory tract -- Serous cavities -- Serous effusions -- Breast -- Alimentary system -- Salivary glands -- Oral cavity -- Oesophagus and gastrointestinal tract -- Hepatobiliary system and pancreas -- Liver -- Gall bladder and extrahepatic bile ducts -- Pancreas -- Kidney and urinary tract -- Kidney and retroperitoneal tissues -- Urine cytology -- Lymphoreticular system -- Lymph nodes -- Other lymphoreticular organs -- Transplantation and immunosuppression -- Organ transplantation -- Immunosuppression -- Endocrine system -- Thyroid gland -- Other endocrine organs -- Male genital tract -- Prostate gland -- Testis and scrotum: cytology of testicular and scrotal masses and male infertility -- Female genital tract -- Vulva, vagina and cervix: normal cytology, hormonal and inflammatory conditions -- Cervical screening programmes -- Cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix -- Glandular neoplasms of the cervix -- Other tumours and lesions of cervix, vulva and vagina -- Cytology of the body of the uterus -- Ovaries, fallopian tubes and associated lesions -- Skin, soft tissues and musculoskeletal system -- Skin -- Soft tissue and musculoskeletal system -- Synovial fluid -- Central nervous system -- Brain and cerebrospinal fluid -- Eyelids, orbit and eye -- Childhood tumours -- New techniques.
  • Diagnostic endoscopy 2014
    Section 1. Basics of endoscopy and light-tissue interactions -- section 2. Endoscopic field imaging modalities -- section 3. Endoscopic point spectroscopy -- section 4. Endoscopic "point" microscopy -- section 5. Clinical applications.
  • The available textbooks on endoscopic ultrasound (EUS) typically focus on technique and interpretation of commonly observed images and scenarios and are aimed primarily at trainees. However, independent practitioners of EUS are often challenged by unusual cases which they are expected to handle competently despite the absence of authoritative guidance. The Diagnostic Endosonography aims to fill this gap by presenting carefully selected cases that will expand the practitioner's knowledge base and cover important clinical challenges. The case material is organized principally according to anatomic site. Approximately 170 case reports are included, each of which is accompanied by an average of three to five high-quality EUS images; in addition, CT and PET scans are shown when appropriate. For each case, the case description is followed by helpful 'teaching points' as well as up-to-date literature references and suggestions for future research.
  • Drs. Christopher P. Crum, Marisa R. Nucci, and Kenneth R. Lee help you diagnose neoplastic and non-neoplastic lesions of the female reproductive tract with their comprehensive updated. This 2nd Edition provides all of the latest guidance needed to accurately evaluate pathologic features and morphologic patterns. With 650+ new color images, an appendix with algorithms for the use of biomarkers, key points, diagnostic pearls, and more. View more than 2,250 full-color photographs and photomicrographs, ideal for side-by-side comparison to the specimens seen in the laboratory. A strong revision to cover the latest updates in the field for one of the only comprehensive references for the practicing pathologist that covers both neoplastic and non-neoplastic disorders of the female genital system.
  • Vol. I: Introduction -- Tumors of the heart and pericardium -- Vascular tumors -- Tumors of the upper respiratory tract -- pt. A: Nasal cavity, paranasal sinuses, and nasopharynx -- pt. B: Larynx, hypopharynx, and trachea -- Tumors of the lung and pleura -- Tumors of the oral cavity -- Tumors of the salivary glands -- Tumors of the esophagus and stomach -- Tumors of the small and large intestines, including anal canal -- Tumors of the liver, biliary tree, and gallbladder -- Tumors of the exocrine pancreas -- Tumors of the urinary tract -- pt. A: Tumors of the kidney -- pt. B: Tumors of the renal pelvis and ureter -- pt. C: Tumors of the urinary bladder and urethra -- Tumors of the female genital tract -- pt. A: Ovary, fallopian tube, and broad and round ligaments -- pt. B: Endometrial tumors -- pt. C: Tumors of the placenta and gestational trophoblastic disease -- pt. D: Myometrium -- pt. E: Cervix -- pt. F: Vagina -- pt. G: Vulva -- Tumors and tumor-like conditions of the male genital tract -- pt. A: Prostate and seminal vesicles -- pt. B: Testicular neoplasms -- pt. C: Penis and scrotum -- Tumors of the peritoneum -- Vol. II: Tumors of the breast -- Tumors of the pituitary gland -- Tumors of the thyroid and parathyroid glands -- pt. A: The thyroid gland -- pt. B: The parathyroid gland -- Tumors of the adrenal gland -- Tumors of the endocrine pancreas -- Tumors of the lymphoreticular system, including spleen and thymus -- pt. A: The lymph node -- pt. B: The spleen -- pt. C: The thymus -- Tumors of the hematopoietic system -- Tumors of the skin -- Tumors of soft tissue -- Tumors of the osteoarticular system -- Tumors of the central nervous system -- Peripheral neuroectodermal tumors -- Tumors of the autonomic nervous system, including paraganglia -- Tumors of the eye and ocular adnexae -- Tumors of the ear -- Molecular genetic techniques in diagnosis and prognosis
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    Volume 1: Introduction -- Tumors of the heart and pericardium -- Vascular tumors -- Tumors of the upper respiratory tract -- Tumors of the lung and pleura -- Tumors of the oral cavity -- Salivary gland tumors -- Tumors of the esophagus and stomach -- Tumors of the small and large intestines (including the anal region) -- Tumors of the liver, gallbladder and biliary tree -- Tumors of the exocrine pancreas -- Tumors of the urinary tract -- Tumors of the female genital tract -- Tumors of the male genital tract -- Tumors of the peritoneum -- Tumors of the breast. Volume 2: Tumors of the pituitary gland -- Tumors of the thyroid and parathyroid glands -- Tumors of the adrenal gland -- Tumors of the endocrine pancreas -- Tumors of the lymphoreticular system -- Tumors of the hematopoietic system -- Tumors of the skin -- Soft tissue tumors -- Tumors of the osteoarticular system -- Tumors of the central nervous system -- Peripheral neuroectodermal tumors -- Tumors of the autonomic nervous system (inlcuding paraganglia) -- Tumors of the eye and ocular adnexa -- Tumors of the ear -- Electron microscopy in tumor diagnosis -- Molecular genetic techniques in diagnosis and prognosis.
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  • 2011 ClinicalKey
    Imaging the head and brain / Joshua Broder and Robert Preston -- Imaging the face / Joshua Broder -- Imaging the cervical, thoracic, and lumbar spine / Joshua Broder -- Imaging soft tissues of the neck / Joshua Broder -- Imaging the chest : the chest radiograph / Joshua Broder -- Imaging chest trauma / Joshua S. Broder -- Imaging of pulmonary embolism and nontraumatic aortic pathology / Joshua Broder -- Cardiac CT imaging / Joshua Broder -- Imaging of nontraumatic abdominal conditions / Joshua Broder -- Imaging abdominal and flank trauma / Joshua Broder -- Imaging abdominal vascular catastrophes /Joshua Broder -- Imaging the genitourinary tract / Joshua Broder -- Imaging of the pelvis and hip / Joshua Broder -- Imaging the extremities / Joshua Broder -- Emergency department applications of musculoskeletal magnetic resonance imaging : an evidence-based assessment / Joshua Broder -- "Therapeutic imaging" : image-guided therapies in emergency medicine / Joshua Broder.
  • Bone Structure and Function / Fayez F. Safadi and Jasvir S. Khurana -- Systematic Approach to Metabolic Diseases of Bone / Akbar Bonakdarpour -- Systematic Approach to Radiology of Endocrine Disorders Affecting the Musculoskeletal System / Akbar Bonakdarpour and Colleen Veloski -- Circulatory Diseases of Bone and Adjacent Soft Tissues / Wilfred C.G. Peh and Seoung-Oh Yang -- Imaging Approach to Musculoskeletal Trauma / William R. Reinus -- Imaging and Understanding Fracture Fixation / Bahman Rafiee -- Systematic Approach to Tumors and Focal Lesions of Bone / Shigeru Ehara and Jasvir S. Khurana -- Systematic Approach to Tumors and Tumor-Like Conditions of Soft Tissue / Theodore T. Miller, Carolyn M. Sofka, Paul Zhang and Jasvir S. Khurana -- Imaging Approach to Hemoglobinopathies / Avneesh Chhabra and William R. Reinus -- Imaging Approach to Musculoskeletal Infections / William R. Reinus -- Systematic Approach to Arthropathies / William R. Reinus -- Imaging of Prostheses / Sayed Ali and William R. Reinus -- Systematic Approach to Skeletal Dysplasias with Emphasis on Non-lethal Disorders / Akbar Bonakdarpour -- Interventional Procedures in Musculoskeletal Radiology / Jamshid Tehranzadeh, Scott Seibert and Afshin Gangi.
  • With its complex anatomy and specialized biomechanics, the human hand has always presented physicians with a unique challenge when it comes to diagnosing and treating the diseases that afflict it. And while recent decades have seen a rapid increase in the number of therapeutic options, many diseases and injuries of the hand are still commonly misinterpreted. In this book, an interdisciplinary team, comprising specialists in radiology, surgery, and rheumatology, presents a comprehensive, reliable guide to this topographically intricate area. Highlights include: More than 1,000 high-quality illustrations; state-of-the-art imaging modalities -- including multiline spiral CR, with 2D displays and 3D reconstructions, and contrast -- enhanced MRI with multi-channel, phased-array coils; an overview of all currently used methods of examination; a detailed presentation of the anatomic and functional foundations necessary for diagnosis; full coverage of all disorders of the hand; and systematic treatment of each disease's definition, pathogenesis, and clinical symptoms, according to a graduated diagnostic plan.
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    Congenital -- Scoliosis -- Vertebral column, discs, and paraspinal muscle -- Cord, dura, and vessels -- Degenerative diseases -- Spondylolisthesis and spondylolysis -- Inflammatory, crystalline, and miscellaneous arthritides -- Infections -- Inflammatory and autoimmune disorders -- Neoplasms -- Nonneoplastic cysts and tumor mimics -- Vascular and systemic disorders -- Plexus and peripheral nerve lesions -- Postoperative imaging and complications -- Hardware -- Post-radiation and chemotherapy complications.
  • Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • Basic issues in interviewing and the interview process / Daniel L. Segal, Andrea June, and Meghan A. Marty -- Interviewing strategies. rapport, and empathy / Catherine Miller -- Presenting problem, history of presenting problem, and social history / Philinda Smith Hutchings and Thomas B. Virden -- Mental status examination / Michael Daniel and Jessica Gurczynski -- Dealing with defense and defensiveness in interviews / Steven N. Gold and Yenys Castillo -- Consideration of neuropsychological factors in interviewing / Brian Yochim -- Anxiety disorders / Rose C. Smith ... [et al.] -- Mood disorders / Leilani Feliciano and Amber M. Gum -- Schizophrenia / Wendy N. Tenhula and Jason Peer -- Personality disorders / Brian P. O'Connor and Edouard S. St. Pierre -- Alcohol problems / David C. Hodgins, Katherine Diskin, and Jonathan N. Stea -- Drug abuse / Jessica F. Magidson, Marina A. Bornovalova, and Stacey B. Daughters -- Sexual dysfunctions and deviations / Caroline F. Pukall, Marta Meana, and Yolanda Fernandez -- Eating disorders / Risa J. Stein, Ryan D. Field, and John P. Foreyt -- Psychophysiological disorders / Ivan R. Molton and Katherine A. Raichle -- Posttraumatic stress disorder / Erin Smith and Sheila A.M. Rauch -- Marital dyads / William Fals-Stewart, Wendy K.K. Lam, and Michelle L. Kelley -- Children / Mary Ashton Phillips and Alan M. Gross -- Sexually and physically abused children / Grace S. Hubel, Mary Fran Flood, and David J. Hansen -- Older adults / Christine Gould, Barry A. Edelstein, and Caroline Ciliberti -- Interviewing inheathh psychology and medical settings / Jay M. Behel and Bruce Rybarczyk.
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    Philosophy and approach to diagnostic parasitology -- Intestinal protozoa: amebae -- Intestinal protozoa: flagellates and ciliates -- Intestinal protozoa (coccidia and microsporidia) and algae -- Free-living amebae -- Protozoa from other body sites -- Malaria and babesiosis -- Leishmaniasis -- Trypanosomiasis -- Intestinal nematodes -- Tissue nematodes -- Filarial nematodes -- Intestinal cestodes -- Tissue cestodes: larval forms -- Intestinal trematodes -- Liver and lung trematodes -- Blood trematodes: schistosomes -- Unusual parasitic infections -- Parasitic infections in the compromised host -- Nosocomial and laboratory-acquired infections -- Immunology of parasitic infections -- Antibody and antigen detection in parasitic infections -- Histologic identification of parasites -- Medically important arthropods -- Treatment of parasitic infections -- Collection, preservation, and shipment of fecal specimens -- Macroscopic and microscopic examination of fecal specimens -- Additional techniques for stool examination -- Examination of other specimens from the intestinal tract and the urogenital system -- Sputum, aspirates, and biopsy material -- Procedures for detecting blood parasites -- Parasite recovery: culture methods, animal inoculation, and xenodiagnosis -- Fixation and special preparation of fecal parasite specimens and arthropods -- Artifacts that can be confused with parasitic organisms -- Equipment, supplies, safety, and quality system recommendations for a diagnostic parasitology laboratory: factors influencing future laboratory practice -- Medical parasitology: case histories.
  • Cystic Fibrosis -- Alport Syndrome -- Alpha Thalassemia -- Charcot-Marie-Tooth Disease -- Hearing Loss -- Polycystic Kidney Disease -- Fragile X Syndrome -- Malignant Hyperthermia -- Rh Incompatibility -- Pharmacogenetics -- B-Cell Lymphoma -- T-Cell Lymphoma -- Posttransplant Lymphoproliferative Disorder -- HIV-Associated Hodgkin Lymphoma -- Chronic Myelogenous Leukemia -- Myeloproliferative Neoplasms -- Acute Myeloid Leukemia: FLT3/NPM1 -- Acute Myeloid Leukemia: CEBPA -- Bone Marrow Engraftment Analysis -- Mixed Phenotype Acute Leukemia -- Breast Cancer -- Lung Adenocarcinoma -- Melanoma -- Thyroid Cancer -- Renal Cell Carcinoma -- Gastrointestinal Stromal Tumor -- Lynch Syndrome -- Oligodendroglioma -- Glioblastoma Multiforme -- Carcinoma of Unknown Primary -- Human Immunodeficiency Virus -- Cytomegalovirus -- Human Papillomavirus -- Chlamydia trachomatis -- MRSA -- Influenza A (H1N1) -- Bordetella pertussis -- Human Metapneumovirus -- BK Virus -- Respiratory Viruses.
  • Also available: Print – 2007
    Smear technique -- Smear patterns -- Reactive lesions -- Infectious diseases -- Infiltrative gliomas -- Other glial tumors -- Neural and primitive tumors -- Hematological tumors -- Extra-axial tumors -- Regional tumors -- Metastatic tumors -- Miscellanea.
  • 1. Introduction / Christiaan Schiepers, p. 1-4 -- Part 1. Clinical Applications -- 2. Neurochemical Imaging with Emission Tomography: Clinical Applications / Giovanni Lucignani and James Frost, p. 7-37 -- 3. Assessment of Myocardial Viability by Radionuclide Techniques / Roxana Campisi, Felix Keng and Heinrich Schelbert, p. 39-59 -- 4. Thromboembolism Imaging / Henry Royal and David Hillier, p. 61-81-- 5. Renal Imaging / François Jamar and Raffaella Barone, p. 83-100 -- 6. Skeletal Scintigraphy / Christiaan Schiepers, p. 101-111 -- 7. Imaging Infection and Inflammation / Huub Rennen, Chantal Bleeker-Rovers and Wim Oyen, p. 113-126 -- 8. Gastrointestinal Nuclear Medicine / Jean-Luc Urbain, p. 127-134 -- 9. Hepatobiliary Scintigraphy / Mark Tulchinsky, p. 135-152 -- 10. Peptide Imaging / Irene Virgolini and T. Traub-Weidinger, p. 153-184 --11. FDG-PET Imaging in Oncology / Christiaan Schiepers and Carl Hoh, p. 185-204 -- 12. PET/CT in Lung, Head and Neck Cancer / Hans Steinert, Gerhard Goerres and Gustav von Schulthess, p. 205-214 -- 13. PET/CT Imaging in Breast Cancer, Gastrointestinal Cancers, Gynecological Cancers and Lymphoma / Martin Allen-Auerbach, Johannes Czernin and Christiaan Schiepers, p. 215-225 -- 14. Pediatric Nuclear Medicine: A Coming of Age / Helen Nadel and Moira Stilwell, p. 227-244 -- Part 2. Basics of Scintigraphic Imaging -- 15. Radiopharmaceuticals: Recent Developments and Trends / Guy Bormans, Kristin Verbeke and Alfons Verbruggen, p. 247-274 -- 16. Instrumentation and Data Acquisition / Sibylle Ziegler and Magnus Dahlbom, p. 275-290 -- 17. Image Formation / Johan Nuyts and Dirk Bequé, p. 291-310 -- Part 3. Future Outlook -- 18. Imaging Gene Expression: Concepts and Future Outlook / Meike Schipper and Sanjiv Gambhir, p. 313-342 -- 19. Quo Vadis? / Christiaan Schiepers, p. 343-344.
  • "Online and print, this comprehensive, organ-based reference is an invaluable tool for the accurate diagnosis of infectious diseases - from the common to the most challenging." "Integrates the latest techniques in immunohistochemistry and molecular genetics throughout the text for comprehensive information on all investigative contexts relevant to ensuring diagnostic accuracy; Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection; Provides a complete visual guide to suspect lesions through superb, high-quality, full-color illustrations of key aspects of various diseases that facilitate the rapid identification of biopsy specimen; Features tables that list differential diagnosis for each lesion for quick summaries of key points in problem areas; and Highlights morphological characteristics and landmarks of tissue samples throughout the text for easy access to information necessary for signing out specimens."--BOOK JACKET.
  • Morphologic Patterns -- Common Diagnostic Discrepancies -- Frozen Section of Ovarian Lesions -- Surface Epithelial Tumors: Pathology Introduction -- Surface Epithelial Tumors: Clinical Introduction -- Pathology of Serous Tumors -- Pathology of Endometrioid Tumors -- Pathology of Clear Cell Tumors -- Pathology of Mucinous Tumors -- Uncommon Epithelial Ovarian Tumors -- Metastatic Tumors -- Germ Cell and Sex Cord Stromal Tumors: Clinical Introduction -- Pathology of Germ Cell Tumors -- Sex Cord Stromal Tumors of the Ovary -- Pathology of Mesenchymal and Hematopoietic Tumors -- Tumors of Uncertain Histogenesis -- Fallopian Tube and Peritoneum -- Familial Cancer and Prophylactic Surgery -- Peritoneal Cytology.
  • Diagnostic Imaging of Lung and Pleural Tumors -- The Staging of Lung Cancer -- Non-Small Cell Carcinomas -- Neuroendocrine Carcinomas -- Biphasic Tumors of the Lungs -- Salivary Gland and Adnexal Type Tumors of the Lungs -- Tumors Derived from Presumed Ectopic Tissues -- Vascular Tumors of the Lungs -- Mesenchymal Tumors of the Lungs -- Lung Tumors of Uncertain Histogenesis -- Malignant Lymphomas Involving Lung and Pleura -- Tumors of the Pleura -- Tumor-like Conditions and Benign Tumors of the Lung -- Molecular Pathology of Lung Cancer.
  • The aim of this publication is to present a comprehensive and detailed account, which brings together and covers all, or at least most, pediatric surgical pathological entities in a single volume, to allow rapid access for day-to-day use.
  • Which disease should you consider when a young adult has localized bone pain that is dramatically relieved by aspirin? What is sometimes the only physical manifestation of bulimia nervosa? These so-called "old fashioned" historical clues and physical signs are not only part of our medical heritage; their deployment can often spell the difference between prompt clinical diagnosis versus a costly investigative odyssey. Often overlooked with today's emphasis on laboratory testing, a diagnostic pearl such as knowing that a diabetic patient with peripheral neuropathy may actually have metformin-induced vitamin B12 deficiency can be a shortcut to disease recognition.Diagnostic Principles and Applications presents selected literature-based facts and diagnostic insights to help clinicians provide better-informed clinical assessments, avoid medical misadventures, and prepare for their board examinations. The chapters cover:Classic diagnostic pearlsRed flag symptoms and signs of serious illnessBellwether disease indications allowing an occasional early, preemptive diagnosisCounterintuitive clinical manifestations of diseaseCurious clues to specific diagnosesRobert B. Taylor, MD is the author and editor of more than two dozen medical books, including three on the topic of clinical diagnosis, and several hundred published articles. He is a veteran of both rural private practice and chairmanship of a medical school clinical department.
  • This new text examines common as well as more difficult diagnostic problems encountered in today's field of breast pathology. The first part of each major section consists of a presentation of general concepts and a detailed description of the pathologic characteristics of specific lesions. Then it focuses on the differences between commonly confused entities and emphasizes pathologic findings to help you obtain the most accurate diagnosis. More than 1,000 illustrations-most in full color-present the key aspects of various diseases in real-life detail.
  • 1. Gene Signatures and Soft Tissue Sarcomas: Status of Art and Perspectives / Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini -- 2. Heterogeneity of Breast Cancer: Gene Signatures and Beyond / Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens -- 3. Gene Signatures in CRC and Liver Metastasis / Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo -- 4. Gene Signatures in Gastrointestinal Stromal Tumors / Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybył, and Maria Debiec-Rychter -- 5. Pancreatic Cancer Genetics / Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti -- 6. Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer / Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei -- 7. Gene Signatures in Gastric Cancer / Laura Ottini, Mario Falchetti, and Gabriella Nesi -- 8. Gene Signatures in Colorectal Cancer / Alessandro Lugli and Inti Zlobec -- 9. The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays / Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia -- 10. Primary Epithelial Ovarian Neoplasms: New Concepts Concerning Origin, Pathogenesis and Classification Based on Morphology, Immunomarkers, Molecular Features, and Gene Expression Studies / Bernard Czernobilsky, Leonor Leider-Trejo, Daniele Fanale, and Antonio Russo -- 11. Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns / Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone.
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  • This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you'll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout. Expert Consult functionality allows you to access the entire contents of the book online, from any internet connection. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Features more than 1700 full-color illustrations that capture the pathologic and cytopathologic appearances of the full range of common and rare neoplastic and non-neoplastic lesions. Allows you to access the entire contents of the book online, from any internet connection, via Expert Consult functionality.
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  • From signs and symptoms to key diagnosis of urological diseases, Diagnostic Techniques in Urology focuses on the current status of urological investigations. This book looks at common conditions of prostate and renal cancer, discusses emergency urological diagnosis, and examines the evaluation of benign diseases as well as miscellaneous urological conditions including erectile dysfunction, incontinence and prostatitis. Bringing together contributions from major international leaders in the field, Diagnostic Techniques in Urology is a useful, easy-to-read book which will benefit urologists and other clinicians interested in urology.
  • Introduction -- Methods (1): Participants and Test Methods -- Methods (2): Statistical Methods -- Results -- Discussion -- Future prospects for diagnostic test accuracy studies in dementia.
  • Over the past 20 years, diagnostic tests for pediatric pulmonologists have revolutionized care of children afflicted with respiratory disorders. These tests have been used to not only help in diagnosis, but also in the management and treatment of these children. Bronchoscopic, imaging and physiologic advances have improved clinical care of these children and have been used as outcome measures in research trials. Diagnostic Tests in Pediatric Pulmonology: Applications and Interpretation describes the various diagnostic modalities (especially the newer ones) that are available for the evaluation of pediatric respiratory disorders. It also provides an understanding of the advantages and limitations of each test so that the clinician may choose the most appropriate ones. An internationally renowned group of authors describe how best to interpret the key findings in a variety of tests as well as the possible pitfalls in incorrect interpretation. This volume focuses on the main diagnostic modalities used in the evaluation of pediatric patients with respiratory disorders and presents up-to-date information on the advantages and limitations of each test for a variety of conditions encountered in the practice of pediatric pulmonology. Clinical utility of these tests is also highlighted. This valuable resource is well suited to practicing clinicians, including pediatric pulmonologists, pediatricians and primary care practitioners, as well as trainees, respiratory therapists and clinical researchers.
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  • Diagnostic Ultrasound Imaging provides a unified description of the physical principles of ultrasound imaging, signal processing, systems and measurements. This comprehensive reference is a core resource for both graduate students and engineers in medical ultrasound research and design. With continuing rapid technological development of ultrasound in medical diagnosis, it is a critical subject for biomedical engineers, clinical and healthcare engineers and practitioners, medical physicists, and related professionals in the fields of signal and image processing. The book contains 17 new and updated chapters covering the fundamentals and latest advances in the area, and includes four appendices, 450 figures (60 available in color), and almost 1,500 references. In addition to the continual influx of readers entering the field of ultrasound worldwide who need the broad grounding in the core technologies of ultrasound, this book provides those already working in these areas with clear and comprehensive expositions of these key new topics as well as introductions to state-of-the-art innovations in this field. Enables practicing engineers, students and clinical professionals to understand the essential physics and signal processing techniques behind modern imaging systems as well as introducing the latest developments that will shape medical ultrasound in the futureSuitable for both newcomers and experienced readers, the practical, progressively organized applied approach is supported by hands-on MATLAB code and worked examples that enable readers to understand the principles underlying diagnostic and therapeutic ultrasound. Covers the new important developments in the use of medical ultrasound: elastography and high-intensity therapeutic ultrasound. Many new developments are comprehensively reviewed and explained, including aberration correction, acoustic measurements, acoustic radiation force imaging, alternate imaging architectures, bioeffects: diagnostic to therapeutic, Fourier transform imaging, multimode imaging, plane wave compounding, research platforms, synthetic aperture, vector Doppler, transient shear wave elastography, ultrafast imaging and Doppler, functional ultrasound and viscoelastic models.
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  • Also available: Print – v. 1-2, 2011.
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  • Fulltext (v.2 1896) Google Books
  • Also available: Print – 1906-
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    Hautkrankheiten / S. Bettmann -- Venerische Krankheiten / E. Riecke.
  • This practical book covers the basic principles and practice of dialysis access management, a crucial part of the care of patients undergoing hemodialysis. It has been written in an easy-to-read, step-by-step format to help facilitate learning and understanding of the procedures, and has been supplemented with numerous operative photographs and diagrams demonstrating the commonly performed dialysis access exams, interventions, procedures and surgeries. Dialysis Access Management is an essential text for residents, fellows, and physicians who are learning or practicing in dialysis and/or dialysis access management, especially in the fields of nephrology, radiology, surgery, and vascular medicine.
  • Definition, epidemiology, pathophysiology, clinical classification, and differential diagnosis of diarrhea -- Infectious gastroenteritis and colitis -- Inflammatory bowel disease -- Eosinophilic enteritis -- Microscopic colitis -- Food allergy -- Protein-losing enteropathies -- Radiation enterocolitis -- Congenital disorders of digestion and absorption -- Pancreatic exocrine insufficiency -- Bacterial overgrowth -- Celiac disease -- Whipple disease -- Surgical conditions presenting with diarrhea -- Chronic diarrheal disorders due to endocrine neoplasms -- Diarrhea from enterotoxins -- Factitious diarrhea -- Chronic idiopathic diarrhea -- Irritable bowel syndrome -- Functional diarrhea (non-specific chronic diarrhea, toddler diarrhea) -- Diarrhea related to non-neoplastic endocrine diseases -- Alcohol-related diarrhea -- Drug-induced diarrhea -- Runner's diarrhea -- Evaluation of patients with diarrhea and timing of referral -- Empiric treatment of chronic diarrhea -- Probiotics for diarrheal diseases.
  • This reference equips you to successfully diagnose and manage even the most complex incidences of diastolic heart failure and their comorbidities. It examines the basic mechanisms of this condition through discussions of both cellular and anatomic causes; guides you through non-invasive techniques for diagnosis, including echocardiography, cardiac CT, and MRI; and provides expert advice on pharmacologic management. Case examples on the accompanying CD-ROM provide a greater understanding of the diagnostic process. Covers the basic mechanisms of diastolic heart problems from both cellular and anatomic perspectives. Features in-depth assessments of all diagnostic methods for diastolic heart failure, including rationales for their use. Examines contributing conditions that play a role in diastolic heart failure and offers guidance on their management. Offers pharmacologic strategies for multiple problem management.
  • Also available: Print – 1989
  • Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
  • In times of emergency, clear communication is critical to saving lives and preventing further destruction. Operations in the field, negotiations between governments and relief organizations, and planning and training sessions all require collaboration among people from various disciplines using different terminologies. Without a common lexicon, misunderstandings and other communication errors can lead to the loss of valuable time, scarce resources, and lives--and during an era marked by climate disasters, warfare, industrial accidents, and threats of bioterrorism, the stakes are increasingly high. It is in this spirit that the original Dictionary of Disaster Medicine and Humanitarian Relief was assembled, and the same holds true for this timely Second Edition. This practical resource boasts more than twice the number of entries as the first edition: definitions, abbreviations, and acronyms covering all phases of humanitarian aid, from planning and preparedness to rescue and recovery. Its contents have been field-tested across the emergency intervention community, and are as useful in communicating with the media and the public as with colleagues. This expanded edition of the Dictionary of Disaster Medicine and Humanitarian Relief ably follows its predecessor as an authoritative resource for researchers and professionals in global health, health promotion, public health, public health policy, and disaster management.
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    This dictionary lists acronyms and abbreviations occurring with a reasonable frequency in the literature of medicine and the health care professions. Abbreviations and acronyms are given in capital letters, with no punctuation, and with concise definitions. The beginning sections also include symbols, genetic symbols, and the Greek alphabet and symbols.
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    The index is found in v. 5 along with separate lists of individuals by country, by fields of activity, and in chronological order by birth year.
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  • This dictionary details various terms typically used in pharmaceutical medicine. It also explains commonly used abbreviations.
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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences. Includes cited reference searching, citation maps, and an analyze tool.Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not. Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines. Over 10,000 notes outline the status of specific infections within each country.
Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.