Books

Summary: This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

Contents:
Vol 1. Basic Principles and General Aspects
Vol 2. Classes, Drugs and Special Aspects
Vol 3. Applied Psychopharmacotherapy.

Summary: "Prepare for success on the neuroimaging component of the radiology Core Exam! Neuroradiology: A Core Review, 2nd Edition, by Dr. Sathish Kumar Dundamadappa, Prachi Dubey, Daniel Thomas Ginat, and Gul Moonis, is an up-to-date, practical review tool written specifically for the Core Exam. This helpful resource contains 500 image-rich, multiple-choice questions with detailed explanations and annoatated images of right and wrong answers, fully revised content, high-yield tables for easy review, and additional eBook questions to ensure you're ready for the Cor Exam or recertification exam."-- From back cover.

Contents:
Neoplastic abnormalities
Inflammatory and demyelinating conditions
Skull, ventricles and developmental abnormalities
Trauma
Brain infections
Inherited and neurodegenerative abnormalities
Vascular abnormalities
Manifestations of toxic, metabolic and systemic pathologies
Spine trauma and degeneration
Spine infection, inflammation and demyelination
Spine neoplastic and vascular abnormalities
Congenital and development abnormalities of the spine
Soft tissue neck
Nose and paranasal sinuses
Orbit
Sella/suprasellar lesions
Skull base
Temporal bone
Noninterpretive skills.

Summary: This book presents a selection of unusual neuroradiology cases, each documented with a short medical history, CT and MRI images, and one page with clinical features and radiological findings. A total of 25 rare and peculiar cases were selected from the authors' clinical experience. Over time, the authors witnessed several of these cases - for which there is little or no information in the international literature - being misinterpreted, especially by residents, general radiologists who occasionally have to deal with neuroradiology cases, or young neuroradiologists. Written by experienced practitioners, this atlas, with its thoroughly documented collection of rare neuroradiological cases, represents a valuable clinical tool for young radiologists and will encourage them to "think outside the box" and successfully find the correct diagnosis.

Contents:
I.Most likely differential diagnose
II.Vascular
III.Infections/Metabolic/Toxic
IV.Skull and orbit anomalities
V.Unusual Spine
VI.Something different.

Summary: The aim of this book is to emphasize firstly that rare and serious conditions can be hidden behind common (mis)leading neurological symptoms. Secondly, it stresses the importance of the collaboration with clinician colleagues - a neuroradiologist needs complete and accurate patient information to make a proper diagnosis or a differential diagnosis that can properly guide further diagnostic processing. The book, structured as an atlas, is divided into three sections according to the most common leading symptoms encountered in hospital emergency units or in outpatient settings. Each proposed case is accompanied by a short medical history, CT and MRI images, and a text describing its most important radiological features. 27 cases were chosen from the authors everyday practice: rare and peculiar cases, as well as common cases with a twist. Although both authors are experienced neuroradiologists, several of the cases were surprising and it took considerable time to arrive at the correct diagnosis. A certain level of knowledge and experience, together with information from literature, the Internet or from clinicians, helped them solve most of the cases directly, or after consultation with clinicians and further medical examinations and interventions. This book is mainly intended for residents, general radiologists and neuroradiologists. However, it will also be of help to less experienced colleagues or trainees who need to solve particular cases, encouraging them to think outside the box to find the answers.

Contents:
I.PAIN AND VERTIGO
Voltage-gated potassium channel (VGKC)-complex antibody limbic encephalitis
Cranial bone changes in megaloblastic anemia due to anorexia nervosa
Multinodular and vacuolating neuronal tumor (MVNT)
Intracranial extra-axial teratoma in an adult female patient
Ruptured dermoid cyst and ischemic stroke (after in-vitro fertilization treatment)
Trigeminal nerve cavernoma
Aortic pseudoaneurysm eroding thoracic spine
Spinal extradural arachnoid cyst
Spinal intramedullary ependymal cysts
Pilocytic astrocytoma at the L5-S1 level
CAPNON
II. EPILEPTIC SEIZURE
Antiphospholipid syndrome in patients with systemic lupus erythematosus elements
Posterior reversible encephalopathy syndrome (PRES): holohemispheric watershed pattern
Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS)
Citrobacter Koseri brain abscess in chronic cocaine addict
Intaventricular meningioma
Large cavernoma vs brain tumor
Supratentorial extraventricular ependymoma vs arteriovenous malformation
Pachymeningeal involvement in acute myeloid leukemia (AML)
Gliosarcoma
Is this really a gliobastoma?
Extradural spinal meningioma
Chronic venous sinus thrombosis vs brain metastases
Progressive multifocal leukoencephalopathy (PML) after obinutuzumab treatment for chronic lymphocytic leukemia (CLL)
Large cerebral vessel vasculitis in undiagnosed HIV positive patient meningovascular syphilis
Cerebral amyloid angiopathy vs primary brain tumor (glioblastoma).

Summary: Make efficient, accurate diagnoses and prepare for imaging exams with a multitude of differential diagnoses accompanied by hundreds of high-quality, unknown cases in neuroradiology. Neuroradiology: Key Differential Diagnoses and Clinical Questions, 2nd Edition, helps you master the skills you need for interpreting imaging of the head, neck, brain and spine for adults and children. All-new cases and extensively revised content throughout bring you up to date and equip you to reach a definitive diagnosis for common, complex, and rare cases.

Contents:
Brain and coverings
Spine
Head and neck
Pediatric neuroradiology.

Summary: "Acquire a better understanding of disease evolution and treatment response with Neuroradiology Spectrum and Evolution of Disease. The unique format includes carefully chosen clinical images that depict the pathologic evolution of disease from initial presentation across the continuum of progression. Colorful graphics plot characteristic changes, helping you visualize how normal and abnormal variations alter over time. Extensive illustrations and concise descriptions distill complex concepts, making this first-of-its-kind resource an excellent tool for imaging interpretation and clinical problem solving"--Publisher's description.

Contents:
Section I: Brain. Parenchymal hemorrhage and trauma.
Brain parenchymal hematoma
Subdural hemorrhage and post-traumatic hygroma
Disorders of cerebral vascular autoregulation. Posterior reversible encephalopathy syndrome
Arteriopathy. Cerebral amyloid angiopathy
Metabolic disorders. Wernicke encephalopathy
Central pontine myelinolysis
Infection. Herpes simplex encephalitis
Toxoplasmosis
Neurocysticercosis
Autoimmune/inflammatory disorders. Acute disseminated encephalomyelitis
Autoimmune encephalitis
Progressive multifocal leukoencephalopathy
Immune reconstitution inflammatory syndrome
Neurosarcoidosis
Tumors. Glial tumors
Hemangioblastoma
Ventricular system alterations. Intracranial hypotension
Intracranial hypertension
Pituitary abnormalities. Partially empty sella
Rathke's cleft cyst
Pituitary apoplexy
Neurodegenerative disease. Hypertrophic olivary degeneration
Section II: Spine. Degenerative Disease. Ossification of the posterior longitudinal ligament
Lumbar interbody fusion
Post-traumatic effects. Kummel's disease
Infection. Discitis-osteomyelitis
Tuberculous spinal infection
Bone lesions. Chordoma
Vertebral hemangioma
Cord lesions. Syringohydromyelia
Cord infarct
Subacute progressive ascending myelopathy
Cord tumors. Spinal cord ependymoma
Astrocytoma
Spine deformity. Hiryama
Thoracic web
Section III: Head and neck. Infection. Orbital Infection
Suppurative thyroiditis
Inflammatory disorders. Thyroid-associated orbitopathy
IgG4-related disease in the head and neck
Sjogren's
Cholesteatoma
Labyrinthitis
Tumors. Paraganglioma
Esthesioneuroblastoma
Post-traumatic effects. Vocal cord augmentation
Bone lesions. Otospongiosis
Paget's
Vascular lesions. Carotid blowout syndrome

Contents:
Brain
Head and neck
Spine.

Summary: "Neuroradiology: The Essentials with MR and CT, Second Edition, written by world-renowned neuroradiologist and MRI pioneer Val Runge, builds on the acclaimed prior edition. The splendidly illustrated compendium features in-depth discussion of important imaging findings, focused primarily on common disease processes. An impressive cadre of international experts contribute to the text, which is written from a clinical radiology perspective and draws from firsthand experiences. MRI physics pearls and tips throughout the book will help radiologists avoid common pitfalls"-- Provided by publisher.

Summary: Focusing on high-yield information, Neuroradiology: The Core Requisites, 5th Edition emphasizes the basics to help you establish a foundational understanding of neuroradiology during rotations, prepare for the core and certifying exams, and refresh your knowledge of key concepts. This completely rewritten and reorganized edition emphasizes the essential knowledge you need in an easy-to-read format, with thorough updates that cover new imaging modalities, the latest guidelines, and integration of physics information throughout. Emphasizes the essentials in a templated, quick-reference format that includes numerous outlines, tables, pearls, boxed material, and bulleted content for easy reading, reference, and recall. Prioritizes and explains key information to help you efficiently and effectively prepare for board exams. Helps you build and solidify conceptual, technical, and interpretive core knowledge needed for imaging the brain, spine, and head and neck. Features hundreds of high-quality images, including diffusion weighted imaging, perfusion imaging, MR and CT angiography, and MR spectroscopy.

Contents:
Intro
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
Dedication
List of Contributors
Foreword
Neuroradiology: Core Requisites, 5e
Preface
Part I: Brain
1. Cranial Anatomy
Topographic Anatomy Supratentorial Brain
Infratentorial Brain
White Matter Tracts
Meninges and Associated Potential Spaces
Ventricular System, Cerebrospinal Fluid, and Cerebrospinal Fluid Spaces
Physiologic Calcifications
Cranial Nerves
Functional Anatomy
Neural Systems
Vascular Anatomy
Skull Base Foramina
2. Intracranial Neoplasms
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
Posttreatment Evaluation
3. Vascular Diseases of the Brain
Relevant Anatomy
Imaging Techniques/Protocols
Pathologies
4. Head Trauma
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
5. Infectious and Noninfectious Inflammatory Disease of the Brain
Abstract
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
Specific Types/Patterns of Intracranial Infections
6. White Matter Disease
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
7. Neurodegenerative Diseases and Hydrocephalus
Anatomic Considerations: Hydrocephalus versus Atrophy
Imaging Techniques and Protocols
Pathology
Atrophy
Metabolic Disorders
8. Congenital Anomalies of the Central Nervous System
Relevant Embryology
Imaging Techniques/Protocols
Supratentorial Congenital Lesions
Infratentorial Abnormalities
Other Congenital Malformations
Congenital Infections
Phakomatoses
Congenital Spinal Anomalies
Skull Anomalies
Perinatal Injury
Part II: Head and Neck
9. Orbit
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
10. Sella and Central Skull Base
Relevant Anatomy
Imaging Techniques/Protocols. Pathology
11. Temporal Bone
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
12. Sinonasal Disease
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
13. Mucosal and Nodal Disease of the Head and Neck
Relevant Anatomy
Imaging Techniques/Protocol
Pathology
Posttreatment Imaging
Future Cancer Risk
14. Extramucosal Disease of the Head and Neck
Relevant Anatomy
VISCERAL SPACE
Imaging Techniques
Pathology Common to Multiple Extramucosal Spaces
Pathology Isolated to Specific Extramucosal Spaces
Masticator Space
Temporomandibular Joint
Dentition/Jaw
Prestyloid Parapharyngeal Space
Carotid Space/Poststyloid Parapharyngeal Space
Retropharyngeal Space
Perivertebral Space
Brachial Plexus
Thyroid Gland
Parathyroid Gland
Part III: Spine
15. Degenerative Disease of the Spine
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
16. Non-degenerative Disease of the Spine
Relevant Anatomy
Imaging Techniques/Protocols
Pathology
Index.

Contents:
Easy cases
Moderately difficult cases
Most difficult cases.

Contents:
Opening round
Fair game
Challenge.

Summary: This book provides a comprehensive, practical, and timely guide to neurorehabilitation for patients affected by tumors of the central nervous system. These patients encounter various physical and psychosocial impairments, due to sensory-motor, psychological and cognitive limitations, as well as depression, anxiety and fatigue. These common tumor and treatment consequences reduce quality of life and produce long-term limitation in functioning and disability that may benefit from rehabilitative interventions. In the early stages of the disease, rehabilitation aims at restoring functioning after tumor treatment, while in the advanced stages, rehabilitation becomes an integral part of palliative care, which aims to increase patients’ independence, to prevent complications and to improve quality of life. Based on an interdisciplinary approach, the book is structured in two main parts. The first is devoted to the basics of cancer and to the main clinical features of the tumors of the nervous system, as well as to the essentials of therapeutic approaches. The second part is dedicated to rehabilitation issues, providing the tools for health personnel to take in charge persons affected by neuro-oncological disease. This unique volume is a valuable resource for all health professionals (physicians, psychologists, trainees nurses specialized in neuro-oncology, occupational therapists, physiotherapists, speech therapists) involved in the interdisciplinary management of individuals affected by tumors of the central nervous system.

Contents:
Seeing the bigger picture : using clients' experiences to shape clinical practice
What happens to the upper limb after brain injury?
The hypertonicity intervention planning model for upper limb neurorehabilitation
Making sense of the clinical picture : assessment and goal setting
Case studies
Movement and strength training
Splinting
Casting
Botulinum neurotoxin
Surgery
Case studies revisited.

Contents:
Part I. Basic framework: motor recovery, learning, and neural impairment
Part II. Human-machine interaction in rehabilitation practice
Part III. Robots for upper extremity recovery
Epilogue: what lies ahead?
Index.

Summary: This revised, updated, and substantially expanded third edition provides an accessible, practical overview of major areas of research, technical development and clinical application in the field of neurorehabilitation movement therapy. The initial section provides the basic framework and a rationale for technology application in movement therapy by summarizing recent findings in neuroplasticity and motor learning. The following section provides a detailed overview of the movement physiology of various neurologic conditions, illustrating how this knowledge has been used to design various neurorehabilitation technologies. The third section then explains the principles of human-machine interaction for movement rehabilitation. The fourth section provides an overview of assessment technology and predictive modeling in neurorehabilitation. The fifth section provides a survey of technological approaches to neurorehabilitation, including spinal cord stimulation, functional electrical stimulation, virtual reality, wearable sensing, brain computer interfaces, mobile technologies, and telerehabilitation. The final two sections examine in greater detail the ongoing revolution in robotic therapy for upper extremity movement and walking, respectively. The promises and limitations of these technologies in neurorehabilitation are discussed, including an Epilogue which debates the impact and utility of robotics for neurorehabilitation. Throughout the book the chapters provide detailed practical information on state-of-the-art clinical applications of these devices following stroke, spinal cord injury, and other neurologic disorders and future developments in the field. The text is illustrated throughout with photographs and schematic diagrams which serve to clarify the information for the reader. Neurorehabilitation Technology, Third Edition is a valuable resource for neurologists, biomedical engineers, roboticists, rehabilitation specialists, physiotherapists, occupational therapists and those training in these fields.

Summary: Cognitive impairment, dysphagia, communication issues, pain, spasticity, bladder dysfunction, sexual dysfunction and bowel incontinence are but a few problems frequently reported by individuals living with long-term neurological conditions. The management of long-term neurological conditions requires co-ordinated inputs from multiple disciplines, and this practical handbook facilitates this by combining physical, cognitive and psychological strategies to patient management. Featuring contributions from leading experts in neurology, health services and clinical rehabilitation, this book is a comprehensive overview of common neurological impairments and solutions. It adopts an evidence-based approach to both pharmacological and non-pharmacological options for alleviating neurological symptoms. An easy-to-refer to guide, bridging multiple disciplines, aided by current research, to provide effective, and practical management for all aspects and issues arising in the rehabilitation phases of the neurological patient. This unique pocketbook is intended for practitioners at all levels, and is ideally suited as a quick guide during ward rounds, out-patient clinics and therapy sessions.

Contents:
An introduction to neurological rehabilitation / Diane Playford and Krishnan Padmakumari Sivaraman Nair
Management of disorders of cognition in neurorehabilitation / Pegah Touradji and Anna V. Agranovich
Management of mood and behaviour in neurorehabilitation / Lewys Morgan and Abhijeeth Shetty
Management of disorders of consciousness in neurorehabilitation / Andreas Bender
Management of communication disorders in neurorehabilitation / Rajani Sebastian and Donna C. Tippett
Management of disorders of eating, drinking, and swallowing in Neurorehabilitation / Rachel Mulheren, Alba Azola and Marlis Gonzalez-Fernandez
Management of salivary disorders in neurorehabilitation / Nicole Rogus-Pulia, Joanne Yee and Korey Kennelty
Management of upper limb impairment in neurorehabilitation / Preeti Raghavan and Manuel Wilfred
Management of vestibular disorders in neurorehabilitation / Adolfo M. Bronstein and Marousa Pavlou
Management of walking disorders in neurorehabilitation / Jonathan F. Marsden
Management of spasticity in neurorehabilitation / Valerie L. Stevenson
Neurorehabilitation in parkinson's disease and parkinsonism / Amit Batla and Fiona Lindop
Neuropathic pain / Alina Zakin and David M. Simpson
Management of phantom limb in neurorehabilitation / Rohit Bhide and Apurba Barman
Management of neuro-ophthalmologic disorders in neurorehabilitation / Simon J. Hickman and Martin J. Rhodes
Management of pressure ulcers in neurological rehabilitation / Ramaswamy Hariharan and Anand Viswanathan
Management of disorders of blood pressure control in neurorehabilitation / Ellen Merete Hagen
Management of neurogenic lower urinary tract dysfunction / Mahreen Pakzad and Pierre Denys
Management of neurogenic bowel dysfunction / Anton Emmanuel
Management of neurogenic sexual dysfunction / Gila Bronner and Tanya Gurevich.

Summary: "Neuroscience: Exploring the Brain surveys the organization and function of the human nervous system. We present material at the cutting edge of neuroscience in a way that is accessible to both science and nonscience students alike. The level of the material is comparable to an introductory college text in general biology. The book is divided into four parts: Part I, Foundations; Part II, Sensory and Motor Systems; Part III, The Brain and Behavior; and Part IV, The Changing Brain. We begin Part I by introducing the modern field of neuroscience and tracing some of its historical antecedents. Then we take a close look at the structure and function of individual neurons, how they communicate chemically, and how these building blocks are arranged to form a nervous system. In Part II, we go inside the brain to examine the structure and function of the systems that serve the senses and command voluntary movements. In Part III, we explore the neurobiology of human behavior, including motivation, sex, emotion, sleep, language, attention, and mental illness. Finally, in Part IV, we look at how the environment modifies the brain, both during development and in adult learning and memory"--Provided by publisher.

Contents:
pt. I. Foundations
1. Neuroscience : past, present, and future
The origins of neuroscience
Views of the brain in ancient Greece
Views of the brain during the Roman Empire
Views of the brain from the Renaissance to the Nineteenth Century
Nineteenth-Century views of the brain
Neuroscience today
Levels of analysis
Molecular
Cellular
Systems
Behavioral
Cognitive
Neuroscientists
The scientific process
Use of animals in neuroscience research
Animal welfare
Animal rights
The cost of ignorance : nervous system disorders
2. Neurons and glia
The Neuron doctrine
The Golgi stain
Cajal's contribution
The prototypical neuron
The soma --The nucleus
Neuronal genes, genetic variation, and genetic engineering
Endoplasmic reticulum
Golgi apparatus
The mitochondrion
The neuronal membrane
The cytoskeleton
The axon
Dendrites
Classifying neurons
Neuronal structure
Gene expression
Glia
Astrocytes
Meylinating glia
Other non-neuronal cells
3. The neuronal membrane at rest
The cast of chemicals
Cytosol and extracellular fluid
The phospholipid membrane
Protein
The movement of ions
Diffusion
Electricity
The ionic basis of the membrane potential
4. The action potential
Properties of the action potential
The action potential, in theory
Membrane currents and conductances
The action potential, in reality
The voltage-gated sodium channel
Action potential conduction
Conduction velocity
Myelin and saltatory conduction
Action potentials, axons, and dendrites
5. Synaptic transmission
Electrical synapses
Chemical synapses
Principles of chemical synaptic transmission
Neurotransmitters
Principles of synaptic integration
Neuropharmacology
6. Neurotransmitter systems
Transmitter release
Synaptic mimicry
Receptors
Ligand-binding
Neurotransmitter chemistry
cholinergic neurons
Catecholaminergic neurons
Serotonergic neurons
Amino acidergic neurons
Other neurotransmitter candidates and intercellular messengers
Transmitter-gated channels
G-protein-coupled receptors and effectors
Divergence and convergence in neurotransmitter systems
7. The structure of the nervous system
Gross organization of the mammalian nervous system
The central nervous system
The peripheral nervous system
The cranial nerves
The meninges
The ventricular system
Understanding CNS structure through development
Neural tube
Three primary brain vesicles
Differentiation of the forebrain
Midbrain
Hindbrain
spinal cord
Special features of the human CNS
A guide to the cerebral cortex
Appendix : an illustrated guide to human neuroanatomy. pt. II. Sensory and motor systems
8. The chemical senses
Taste
Basic tastes
Organs of taste
Taste receptor cells
Mechanisms of taste transduction
Central taste pathways
Neural coding of taste
Smell
The organs of smell
Olfactory receptor neurons
Central olfactory pathways
Spatial and temporal representations of olfactory information
9. The eye
Properties of light
Light
Optics
The structure of the eye
Gross anatomy of the eye
Cross-sectional anatomy of the eye
Image formation by the eye
Refraction by the cornea
Accommodation by the lens
The Pupillary light reflex
The visual field
Visual acuity
Microscopic anatomy of the retina
Photoreceptor structure
Phototransduction
Rods
cones
Dark and light adaptation
Calcium's role
Local adaptation of dark, light, and color
Retinal processing and output
Receptive field
Bipolar cell receptive fields
Ganglion cell receptive fields
Ganglion cell photoreceptors
Parallel processing
10. The central visual system
The retinofugal projection
The optic nerve, optic chiasm, and optic tract
Right and left visual hemifields
Targets of the optic tract
The lateral geniculate nucleus
Anatomy of the striate cortex
Retinotopy
Cytochrome oxidase blobs
Physiology of the striate cortex
Receptive fields
Parallel pathways and cortical modules
Beyond the striate cortex
The dorsal stream
The ventral stream
From single neurons to perception
11. The auditory and vestibular systems
The nature of sound
The structure of the auditory system
The middle ear
Ossicles
The attenuation reflex
The inner ear
anatomy of the cochlea
Hair cells and the axons of the auditory nerve
Central auditory processes
Auditory pathway
Encoding sound intensity and frequency
Stimulus frequency, tonotopy, and phase locking
Mechanism of sound localization
Horizontal plane
Vertical plane
Auditory cortex
Neuronal response properties
Effects of auditory cortical lesions and ablation
The vestibular system
The vestibular labyrinth
The otolith organs
The semicircular canals
Central vestibular pathways and vestibular reflexes
Vestibular pathology
12. The somatic sensory system
Touch
Mechanoreceptors of the skin
Vibration and the pacinian corpuscle
Mechanosensitive ion channels
Primary afferent axons
The spinal cord
The dorsal column-medial lemniscal pathway
The trigeminal touch pathway
Somatosensory cortex
Pain
Nociceptors and the transduction of painful stimuli
Hyperalgesia and inflammation
Itch
Primary afferents and spinal mechanisms
Ascending pain pathways
The spinothalamic pain pathway
The trigeminal pain pathway
The thalamus and cortex
The regulation of pain
Temperature
Thermoreceptors
The temperature pathway
13. Spinal control of movement
The somatic motor system
The lower motor neuron
Alpha motor neurons
Types of motor units
Excitation-contraction coupling
Muscle fiber structure
Spinal control of motor units
Proprioception from muscle spindles
Gamma motor neurons
Proprioception from golgi tendon organs
Spinal interneurons
The generation of spinal motor programs for walking
14. Brain control of movement
Descending spinal tracts
The lateral pathways
The ventromedial pathways
The planning of movement by the cerebral cortex
Motor cortex
Posterior parietal and prefrontal cortex
Neuronal correlates of motor planning
Mirror neurons
The basal ganglia
Basal ganglia disorders
The initiation of movement by primary motor cortex
The cerebellum
The motor loop through the lateral cerebellum. pt. III. The brain and behavior
15. Chemical control of the brain and behavior
The secretory hypothalamus
Homeostasis --Pathways to the pituitary
The autonomic nervous system
ANS circuits
Sympathetic and parasympathetic divisions
The enteric division
Neurotransmitters and the pharmacology of autonomic function
Preganglionic neurotransmitters
Postganglionic neurotransmitters
The diffuse modulatory systems of the brain
The serotonergic raphe nuclei
The dopaminergic substantia nigra and ventral tegmental area
The cholinergic basal forebrain and brain stem complexes
Drugs and the diffuse modulatory systems
Hallucinogens
Stimulants
16. Motivation
The hypothalamus, homeostasis, and motivated behavior
The long-term regulation of feeding behavior
energy balance
Hormonal and hypothalamic regulation of body fat and feeding
The short-term regulation of feeding behavior
Appetite, eating digestion, and satiety
Ghrelin
Gastric distension
Cholecystokinin
Insulin
Why do we eat?
Reinforcement and reward
The role of dopamine in motivation
Serotonin, food, and mood
Other motivated behaviors
Drinking
Temperature regulation
17. Sex and the brain
Sex and gender
The genetics of sex
Sex chromosome abnormalities
Sexual development and differentiation
The hormonal control of sex
Principal male and female hormones
Control of sex hormones by the pituitary and hypothalamus
The neural basis of sexual behaviors
Reproductive organs and their control
Mammalian mating strategies
The neurochemistry of reproductive behavior
Love, bonding and the human brain
Why and how male and female brains differ
Sexual dimorphisms of the central nervous system
Sexual dimorphisms of cognition
Sex hormones, the brain, and behavior
Direct genetic effects on behavior and sexual differentiation of the brain
The activational effects of sex hormones
Brain changes associated with maternal and paternal behavior
Estrogen effects on neuron function, memory, and disease
18. Brain mechanisms of emotion
Early theories and neural representations
The James-Lange Theory
The Cannon-Bard Theory
Implications of unconscious emotion
The limbic system
Broca's limbic lobe
The Papez circuit
Emotion theories and neural representations
Basic emotion theories
Dimensional emotion theories
What is an emotion?
Fear and the amygdala
The Klüver-Bucy Syndrome
Anatomy of the amygdala
Effects of amygdala stimulation and lesions
A neural circuit for learned fear
Anger and aggression
The amygdala and aggression
Neural components of anger and aggression beyond the amygdala
Anger, aggression, and the hypothalamus
The midbrain and aggression
Serotonergic regulation of anger and aggression
19. Brain rhythms and sleep
The electroencephalogram
Recording brain waves
EEG rhythms
Mechanisms and meanings of brain rhythms
Synchronous rhythms
Seizures of epilepsy
Sleep
The functional states of the brain
The sleep cycle
Why do we sleep?
Functions of dreaming and REM sleep
Neural mechanisms of sleep
Wakefulness and the ascending reticular activating system
Falling asleep and the non-REM state
Mechanism of REM sleep
Sleep-promoting factors
Gene expression during sleeping and waking
Circadian rhythms
Biological clocks
The suprachiasmatic nucleus : a brain clock
20. Language
What is language?
Human sound and speech production
Language in animals
Language acquisition
Genes involved in language
FOXP2 and verbal dyspraxia
Genetic factors in specific language impairment and dyslexia
The discovery of specialized language areas in the brain
Broca's Area and Wernicke's Area
Language insights from the study of aphasia
Broca's aphasia
Wernicke's aphasia
The Wernicke-Geschwind model of language and aphasia
Conduction aphasia
Aphasia in bilinguals and deaf people
Asymmetrical language processing the two cerebral hemispheres
Language processing split-brain humans
Left hemisphere language dominance
Language functions of the right hemisphere
anatomical asymmetry and language
Language studies using brain stimulation and human brain imaging
21. The resting brain, attention, and consciousness
Resting state brain activity
The brain's default mode network
Attention
Behavioral consequences of attention
Physiological effects of attention
Brain circuits for the control of attention
The pulvinar
The frontal eye fields, eye movements, and attention
Salience and priority maps
A priority map in the parietal lobe
The frontoparietal attention network
22. Mental illness
Mental illness and the brain
Psychosocial approaches to mental illness
Biological approaches to mental illness
Anxiety disorders
Panic disorder
Agoraphobia
Other disorders characterized by increased anxiety
Post-traumatic stress disorder
Obsessive-compulsive disorder
Biological bases of anxiety disorders
Treatments of anxiety disorders
Psychotherapy
Anxiolytic medications
Affective disorders
Major depression
Bipolar disorder
Biological bases of affective disorders
The monoamine hypothesis
The diathesis-stress hypothesis
Anterior cingulate cortex dysfunction
Treatments for affective disorders-- Electroconvulsive therapy
Psychotherapy
Antidepressants
Lithium
Deep brain stimulation
Schizophrenia
Biological bases of schizophrenia
Genes and the environment
The dopamine hypothesis
The glutamate hypothesis
Treatments for schizophrenia. pt. IV. The changing brain
23. Wiring the brain
The genesis of neurons
Cell proliferation
Cell migration
Cell differentiation
Differentiation of cortical areas
The genesis of connections
The growing axon
Axon guidance
Synapse formation
The elimination of cells and synapses
Cell death
Changes in synaptic capacity
Activity-dependent synaptic rearrangement
Synaptic segregation
Synaptic convergence
Synaptic competition
Modulatory influences
Elementary mechanisms of cortical synaptic plasticity
24. Memory systems
Types of memory and amnesia
Declarative and nondeclarative memory
Procedural memory
Declarative memory
Amnesia
Working memory
The prefrontal cortex and working memory
Area LIP and working memory
Declarative memory
The neocortex and declarative memory
Hebb and the cell assembly
Studies implicating the medial temporal lobes
Temporal lobe amnesia
Temporal lobectomy and amnesia
An animal model of human amnesia
Memory functions of the hippocampal system
Hippocampal lesions
Spatial memory, place cells, and grid cells
Hippocampal functions beyond spatial memory
Consolidating memories and retaining engrams
Procedural memory
The striatum and procedural memory in rodents
Habit learning in humans and nonhuman primates
25. Molecular mechanisms of learning and memory
Memory acquisition
Cellular reports of memory formation
Distributed memory storage
Strengthening synapses
Anatomy of the hippocampus
Weakening synapses
LTP, LTD, and memory
Synaptic homeostasis
Metaplasticity
Synaptic scaling
Memory consolidation
Persistently active protein kinases
Protein synthesis and memory consolidation
synaptic tagging and capture
CREB and memory
Structural plasticity and memory.

Summary: "The book provides an overview of the certification exams written specifically by the certification organizations themselves. Distinctive to this book is a format of asking a question and thinking through a response with rationales. This review book is unique in "Think in Questions" format, which helps readers to anticipate the kinds of questions that might be asked and promote critical thinking throughout the exam. The content review is comprised of bite-sized sections for easier learning and memorization that includes thousands of unfolding questions, answers, and hints"-- Provided by publisher.

Contents:
Chronic neurological trauma
Cerebrovascular disorders
Tumors of the brain and spinal cord
Immune/Infections part 1
Immune/infections part 2
Seizures
Pediatric and developmental disorders
Neurological trauma : traumatic brain injury
Neurological trauma : spinal cord injury
Practice exam
Answers and rationales for the practice exam
Bonus exam questions
Answers and rationales for the bonus exam questions.

Contents:
Preface: Neuroscience for addiction medicine: from prevention to rehabilitation
Part 1: Neuroscience constructs for addiction medicine. Neuroscience of resilience and vulnerability for addiction medicine: from genes to behavior
Drug-induced neurotoxicity in addiction medicine: from prevention to harm reduction
Stress psychobiology in the context of addiction medicine: from drugs of abuse to behavioral addictions
Reinforcement principles for addiction medicine; from recreational drug use to psychiatric disorder
Neuroscience of attentional processes for addiction medicine: from brain mechanisms to practical considerations
Neuroscience of learning and memory for addiction medicine: from habit formation to memory reconsolidation
Neuroscience of drug craving for addiction medicine: from circuits to therapies
Response inhibition and addiction medicine: from use to abstinence
Neuroscience of inhibition for addiction medicine: from prediction of initiation to prediction of relapse
Part 2: Drugs and behaviours for addiction medicine. Neuroscience of nicotine for addiction medicine: novel targets for smoking cessation medications
Neuroscience of alcohol for addiction medicine: neurobiological targets for prevention and intervention in adolescents
Neuroscience of opiates for addiction medicine: from stress-responsive systems to behavior
Opioid neuroscience for addiction medicine: from animal models to FDA approval for alcohol addiction
Competing neurobehavioral decision systems theory of cocaine addiction: from mechanisms to therapeutic opportunities
Clinical neuroscience of amphetamine-type stimulants: from basic science to treatment development
Behavioral addictions in addiction medicine: from mechanisms to practical considerations
Neural systems implicated in obesity as an addictive disorder: from biological to behavioral mechanisms.

Contents:
Preface: Neuroscience for addiction medicine: from prevention to rehabilitation
Part I: Neuroscience methods for addiction medicine. Animal models for addiction medicine: from vulnerable phenotypes to addicted individuals
Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
Computational modeling for addiction medicine: from cognitive models to clinical applications
Electrophysiology for addiction medicine: from methodology to conceptualization of reward deficits
Neurocognitive rehabilitation for addiction medicine: from neurophysiological markers to cognitive rehabilitation and relapse prevention
Structural imaging for addiction medicine: from neurostructure to neuroplasticity
Functional neuroimaging for addiction medicine: from mechanisms to practical considerations
Resting state functional connectivity analysis for addiction medicine: from individual loci to complex networks
PET imaging for addiction medicine: from neural mechanisms to clinical considerations
Genetic imaging consortium for addiction medicine: from neuroimaging to genes
Part II: Neuroscience for interventions in addiction medicine. Human pharmacology for addiction medicine: from evidence to clinical recommendations
Emerging targets for addiction neuropharmacology: from mechanisms to therapeutics
Cognitive interventions for addiction medicine: understanding the underlying neurobiological mechanisms
Adolescent psychotherapy for addiction medicine: from brain development to neurocognitive treatment mechanisms
Cognitive neuroscience of cognitive retraining for addiction medicine: from mediating mechanisms to questions of efficacy
Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders: from cognitive improvement to relapse prevention
Noninvasive brain stimulation for addiction medicine: from monitoring to modulation
What the alcohol doctor ordered from the neuroscientist: theragnostic biomarkers for personalized treatments
What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses.

Summary: A practical, reader-friendly guide for dental students on the neuroscience of the orofacial region Understanding neural mechanisms that control orofacial pain, proper masticatory function, taste, speech, swallowing, and proprioceptive input to the temporomandibular joint and teeth is an important facet of dentistry. Neuroscience of Dentistry by renowned educators Barbara J. O'Kane and Laura C. Barritt provides foundational knowledge on these topics. The text integrates fundamental concepts of general neuroscience with vital information on neural mechanisms of the orofacial region and associated pain pathways. The book is organized in two parts covering basic neuroscience and orofacial neuroscience. Part one is subdivided into four units on the central nervous system, brain and spinal cord gross anatomy, sensory systems, and motor systems. Part two features three units focused on orofacial structures and tissues, dental structures, and orofacial pain and anesthesia. Each generously illustrated, succinctly written, and consistently formatted chapter includes an introductory overview and learning objectives. Key Highlights Throughout the book, relevant clinical correlations emphasize the relationship between basic neuroscience and clinical practice Concise, high-yield illustrations, schematics, charts, and tables enhance understanding of general and orofacial neuroanatomy concepts Helpful overviews at the beginning of each chapter highlight key concepts National board style questions at the end of each chapter emphasize board-relevant information that enables self-study This is a must-have resource for dental students taking neuroscience during their first or second year of dental school. It will also benefit other health science and dental hygiene students, as well as oral and maxillofacial surgery residents.

Summary: The first neuroanatomy text written specifically for physical therapy studentsWritten by recognized experts in human nervous system development, Neuroanatomy for Rehabilitation provides physical therapy students with a thorough understanding of the anatomical localization of brain function. Approximately 200 line illustrations and photographs teach students how to accurately interpret the wealth of new human brain images now available.The text opens with an informative section that discusses the structural and functional organization of the nervous system and includes coverage of functional neuroanatomy and response to injury. This is followed by sections covering: Vascular Supply of the Central Nervous System (arterial supply, venous drainage, response to injury), Cellular Organization of the Nervous System, Development of the Central Nervous System, Functional Neuroanatomy by Ascending Region, The Brainstem, Cranial Nerves and Visual Pathways, The Cerebellum and Basal Ganglia, Diencephalon, The Cortex. Each section opens with a case study and an overview of key concepts, and concludes with case discussion and review questions. No other text provides physical therapy students and instructors with such relevant, authoritative, and well-written material designed to enhance understanding of the human nervous system as Neuroanatomy for Rehabilitation. [Ed.].

Contents:
Structural and functional organization of the nervous system
Vascular supply of the central nervous system
Cellular organization of the nervous system
Development of the central nervous system
The spinal cord
The brainstem, cranial nerves and visual pathways
Cerebellum --Basal nuclei
Diencephalon
Cerebral cortex.

Summary: Develop an understanding of neuroscience as it relates to your future career as a clinician, researcher, or instructor with this revised best-seller. The 5th Edition provides an easy-to-understand, meaningful overview of the basics of essential neuroscience concepts enhanced by case studies that connect neuroscience to the disorders you'll see in practice. Features eBook available. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and much more. NEW! The complexity of neuroscience has been simplified in every chapter, making it easier for you to master key neurological concepts. NEW! Expanded Clinical Correlates sections include more treatment examples and mental function cases, as well as applied Clinical Relevance boxes. NEW! Additional chapter-ending, problem-solving case studies deepen your understanding and help you hone your critical thinking skills. A consistent, step-by-step structure beginning in Chapter 4 supports learning through learning objectives, chapter introductions, anatomy and terminology by structure, clinical concerns with neurologic concepts including pathology, and a clinical application. Charts, graphs, diagrams, illustrations, brain mapping pictures, and MR and CT images (both normal and with pathologies) help you prepare for you­r future role as an SLP therapist or audiologist. Chapter-ending learning aids include summaries and review questions (with answers at the end of the book). An end-of-book glossary helps you master the vocabulary of neuroscience. Interactive, online study tools, including animations, video clips, labeling exercises, a digital Student Workbook, and more, help you master the content you need to succeed in your course and future career.

Contents:
Essential neurological concepts
Gross anatomy of the central nervous system
Internal anatomy of the central nervous system
Development of the nervous system
Nerve cell physiology
Diencephalon : thalamus and associated structures
Cerebrovascular system
Ventricles and cerebrospinal fluid
Auditory system
Vestibular system
Somatosensory system
Visual system
Motor system 1 : spinal cord
Motor system 2 : cerebellum
Motor system 3 : basal ganglia
Motor system 4 : motor cortex
Synopsis of cranial nerves
Axial-limbic brain: autonomic nervous system, limbic system hypothalamus, and reticular formation
Cerebral cortex : higher mental functions
Clinical concepts in neuroradiology, neurosurgery, neurology, neurolinguistics, genetics, and pharmacology and their applications.

Contents:
Neurogenetics of Aggressive Behavior
Studies in Rodents
Neurogenetics of Aggressive Behavior
Studies in Primates
Glucocorticoids and Escalated Aggressive Behavior.-Models of Female Aggression
Prefrontal Cortex.-Nitric Oxide, Serotonin and Aggression
Hypothalamus and Aggressive Behavior
Vasopressin-Serotonin Interactions in Aggressive Behavior
Dopamine-oxytocin: Attachment and Conflict
Stress and violence.-Gene-environment interactions and violence.-MAO-A and genetic risk for violence
The development of violent behavior in humans
Schizophrenia and violence.-Psychopathy
Violent and callous behavior in children
Aggression in Children and Adolescents-Alcohol and Aggression.

Contents:
Neuroanatomy
Cells and circuits
Neurotransmitters
Receptors and signaling the nucleus
Genetics and epigenetics
Hormones and the brain
Plasticity and adult development
Immunity and inflammation
The electrical brain
Pain
Pleasure
Appetite
Anger and aggression
Sleep
Sex and the brain
Social attachment
Memory
Intelligence
Attention
Depression
Anxiety
Schizophrenia
Alzheimer's disease.

Summary: The Neuroscience of Empathy, Compassion, and Self-Compassion provides contemporary perspectives on the three related domains of empathy, compassion and self-compassion (ECS). It informs current research, stimulates further research endeavors, and encourages continued and creative philosophical and scientific inquiry into the critical societal constructs of ECS. Examining the growing number of electrocortical (EEG Power Spectral, Coherence, Evoked Potential, etc.) studies and the sizeable body of exciting neuroendocrine research (e.g., oxytocin, dopamine, etc.) that have accumulated over decades, this reference is a unique and comprehensive approach to empathy, compassion and self-compassion.

Contents:
Executive function
Memory
Emotion processing
Dissociation
Sleep
Self-injurious behaviors
Comorbidity in pediatric PTSD
Treatment outcomes
Brain function in pediatric PTSD : review and implications.

Summary: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: statedependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.

Contents:
Neurosecretion: A Historical Overview
Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals
Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus
Somato-Dendritic Secretion of Neuropeptides
Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown
Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion
Secretory Astrocytes
Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells
Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion
Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles
Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes
How Do Bacterial Neurotoxins Affect Neurosecretion?
Secretory Mechanisms in Paramecium.

Summary: Although, within neurosonology, study of both the extracranial and the intracranial circulation began at least 15 years ago, it is only in recent years that ultrasound evaluation of cerebral veins and cerebral venous hemodynamics has attracted wider attention. Nevertheless, the huge variability in venous outflow pathways in normal subjects means that the potential usefulness of this examination is still often neglected. This atlas provides concise descriptions of the main normal and pathological ultrasound features of the cerebral venous circulation for neurosonologists and clinicians. It is designed as a practical tool that will be of assistance in everyday practice in the ultrasound lab and will improve the knowledge of sonologists and the reliability of venous ultrasound studies. The multimedia format, with detailed images, explanatory videos, and short, targeted descriptions, ensures that information is clearly conveyed and that users will become fully acquainted with the variability of normal findings of venous examinations. The atlas will be of value both to trainees in this field of ultrasound and to neurosonologists who are beginning to perform venous examinations in addition to arterial extra- and intracranial examinations.

Contents:
Part I Extracranial veins
1 Ultrasound machine: the significance of venous preset
2 Ultrasound anatomy and how to do the examination
3 Postural changes and activation tests
4 Main pathological pictures with ultrasound
Part II Intracranial veins
5 Ultrasound machine: the significance of venous preset
6 Ultrasound anatomy and how to do the examination
7 Main pathological pictures with ultrasound
8 Global hemodynamic evaluation and outflow variability
9 Imaging-fusion technology for studying intracranial veins. .

Summary: "Neurosonology is a first-line modality in the diagnosis and management of cerebrovascular disease and especially of stroke. In this new edition of Neurosonology and Neuroimaging of Stroke, this noninvasive, realtime imaging method has been given expanded coverage, particularly for its clinical utility. As in the first edition, the new edition offers both a clear overview of the principles of neurosonology and a casebook exploring critical cerebrovascular problems. Ultrasound anatomy, technical aspects of clinical application, and the advantages and limitations of ultrasound are reviewed and contrasted to conventional, magnetic resonance, and computed tomography angiography. Forty-five selected cases from the authors' extensive collections at Charite - Universitatsmedizin Berlin and the Center of Neurology in Bad Segeberg, Germany, are then discussed. The patient histories and working diagnoses are followed by detailed assessments of the extra- and intracranial color-coded duplex sonographic findings and additional diagnostic procedures. The relevant clinical aspects are presented in a compact, comprehensible way, and for the majority of the cases videos are available in the Thieme MediaCenter, providing further in-depth understanding of the full potential of the method. Features:Complete extra- and intracranial arterial and venous ultrasound examination. New techniques: ultrasound fusion imaging, ultrafast ultrasound, contrast applicationMore than 1,300 high-quality illustrations, including full-color duplex images. Fifteen newly selected cases on conditions such as subarachnoid hemorrhage and dural fistula, as well as rare stroke causes including sickle cell disease and reversible cerebral vasoconstriction syndrome. Revision of many cases from the first edition. More than 60 new video clips (for a total of 130) available at the Thieme MediaCenter, bringing ultrasound anatomy and challenging cases to your monitor! Neurosonology and Neuroimaging of Stroke, Second Edition, offers neurologists, neuroradiologists, and all physicians treating patients with cerebrovascular disease an authoritative introduction and guide to this powerful diagnostic tool"--Provided by publisher.

Summary: This textbook addresses the classical use of Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex Sonography (TCCS), focusing on the usefulness of neurological monitoring beyond classical acute brain injuries present in the daily intensive care medical practice. It encompasses a wide range of critical pathologies where neurological impact is part of clinical evolution, offering practical approaches for managing, application and interpretation of neurosonology to assist the physician to making real-time individualized decisions at bedside. It is an academic guide developed and edited by international experts being a very useful resource in daily practice for intensivists, neurologists, neurosurgeons and other specialists involving in critical care.

Contents:
Part I. Neurocritical Care: Concepts to Review
Part II. Neurosonology: Basic Principles
Part III. Neurosonology: Neurocritical Care Patient
Part IV. Neurosonology: Beyond Usual Monitoring.

Summary: This book is a combination of ideas and experiences from over 100 dedicated and brilliant neurosurgeons around the world. Their common goal is to provide data for a deeper understanding of the multi-faceted aspects of neurosurgery and, by doing so, to better serve patients across the globe. Scientific curiosity, deep dedication, incredible work ethics, entrepreneurship, and creativity are the common traits among all neurosurgeons, and not the exception. By allowing readers to see the field of neurosurgery from the perspectives of surgeons spanning five continents, this book serves to provide multiple, diverse viewpoints and to build a foundation for future collaborations. The books 24 chapters are organized into 3 parts. Part I provides the reader with an overview of the role of neurosurgery in worldwide health care, its evolution over the past decades, the current state and future directions of each neurosurgical subspecialty across the five continents. Over the years, the overarching goal for neurosurgeons has been to develop new, more effective and high-end solutions for complex diseases and to provide access to neurosurgical services for all patients. Part II discusses the differences and similarities of neurosurgery education and training across the globe, providing a snapshot of how new tools, technology, and paradigms reduce inequality and increase access to neurosurgical education. Educational accomplishments and challenges still present for the in different regions of the world are reviewed. Part III focuses on economic aspects influencing neurosurgery globally, including how to make efficient decisions in the face of scarcity, yet demand. The authors provide theories, models, and tools helpful to apply when planning to allocate resources, not just financial, but also human and intellectual. A deeper understanding of economics does not necessarily provide the answer to the problem; rather it provides the tools to find an answer, or, ideally, multiple possible solutions. Neurosurgery and Global Health is the first comprehensive guide to the role of neurosurgery in the global health care sphere, providing an in-depth compendium about the understanding of the neurosurgical role within global health, its efforts in the education of tomorrows workforce, and the economic aspects driving the field.

Contents:
The Role of Neurosurgery in Worldwide Healthcare and its Disparities: An Overview
Historical Perspective: The History of Neurosurgery
Head Trauma
Pediatric Neurosurgery
Cerebrovascular Neurosurgery
Neurosurgical oncology
Spine
The role of Neurosurgey in Global Health Radiosurgery, Function and Epilepsy Surgery
Integrating Mass casualty Disaster response
Quality of Care and Patient Safety in Global Neurosurgery
Ethical and Legal Considerations in Neurosurgery
Future Directions
Africa
Asia
Australasia
Europe
Central and South America
North America: Canada, United States and Mexico
The Neurosurgery enterprise and stakeholders
Medical Technology innovation and Entrepreneurship in Neurosurgery
Digital Technology in Neurosurgery: a successful Entrepreneurship story
The role of nonprofit and academic institutions in global Neurosurgery
The World Health Organization and Neurosurgery
The impact of Covid-19 pandemic in Neurosurgery world.

Summary: "Neurosurgery Case Review: Questions and Answers, 2nd Edition by Remi Nader, Abdulrahman Sabbagh, Samer Elbabaa, Hosam Al Jehani, Jaime Gasco, and Cristian Gragnaniello provides a robust study guide for the American Board Neurological Surgery and the Royal College of Physicians and Surgeons of Canada oral board examinations. The second edition expands on the highly successful first edition, presenting 148 cases commonly encountered by neurosurgeons in clinical practice. The cases are broadly divided into seven sections-tumor, vascular intracranial pathology, trauma, pediatric, functional, spine, and peripheral nerves. The chapters are arranged in a manner that mirrors the oral board exam. Each case includes a brief clinical scenario followed by questions on presentation, diagnosis, imaging, management, surgical detail, complications, and outcome. The presented information is backed by the latest available evidence-based references and data. Key Features: Contributions from internationally renowned neurosurgical educators Detailed answers enhance readers' knowledge and provide guidance on how to respond to questions asked in the oral board exams More than 760 high-quality images, many in full color, ensure visual understanding of key concepts Suggested readings at the end of cases offer additional study resources This is an indispensable, one-stop resource for neurosurgical residents and fellows prepping for the ABNS and Royal College oral board examinations. Neurosurgeons studying for recertification will also find this book an invaluable reference for rapid review"-- Provided by publisher.

Summary: "The book is devoted to the neurosurgical management of spasticity. Starting with a chapter on the anatomical and physiological foundations of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen Therapy (ITB), botulinum toxin therapy, and surgery. Beyond ITB, the neurosurgical options covered include procedures focusing on the peripheral nerves, dorsal roots, Dorsal Root Entry Zone and spinal cord. Based on surgical experience collected with more than a thousand patients, the book gathers the most important aspects of our present understanding, presented using a practical, educational approach. It stresses the importance of a multidisciplinary approach, including neurologists, pediatricians and rehabilitation specialists. Close collaboration with other surgical disciplines like orthopedic surgery and neuro-urology are also outlined."--Publisher's website.

Summary: "Surgery requires a combination of knowledge and skill acquired through years of direct observation, mentorship, and practice. The learning curve can be steep, frustrating, and intimidating for many medical students and junior residents. Too often, books and texts that attempt to translate the art of surgery are far too comprehensive for this audience and counterproductive to learning important basic skills to succeed. Neurosurgery Outlines by neurosurgeon Paul Kaloostian is the neurosurgical volume in a series of textbooks that offer a simplified roadmap to surgery. This unique resource outlines key steps for common surgeries, laying a solid foundation of basic knowledge from which trainees can easily build and expand. The text serves as starting point for learning neurosurgical techniques, with room for adding notes, details, and pearls collected during the journey. Chapters are systematically organized and formatted by subspecialty, encompassing spine, radiosurgery, brain tumors and vascular lesions, head trauma, functional neurosurgery, epilepsy, pain, and hydrocephalus. Each chapter includes symptoms and signs, surgical pathology, diagnostic modalities, differential diagnosis, treatment options, indications for surgical intervention, step-by-step procedures, pitfalls, prognosis, and references where applicable"-- Provided by publisher.

Contents:
Neuroanatomy
Neurophysiology
Neuropathology
Neuropharmacology
Cranial neurosurgery
Spine
Peripheral nerves
Neurology
Neuroradiology.

Summary: "Neurosurgery Tricks of the Trade: Cranial presents core surgical procedures in a concise, highly didactic format, enabling surgeons to quickly grasp their essence from the bulleted text and superb illustrations that accompany them. Expert neurosurgeons specializing in the cranial region describe how they perform common procedures and offer surgical tips and pearls. Key Features: - Distills a wealth of information in a concise, step-by-step format, making it easy for novice surgeons to review how procedures are performed - Includes more than 150 surgical procedures for the cranial region, each accompanied by high-quality, original illustrations - Presents topics in either a pathology-based or an approach-based manner - Consistently organizes the procedures into the headings: Introduction and Background, Operative Detail and Preparation, Outcomes and Postoperative Course, and References, enabling rapid reference. Neurosurgeons at all levels, from residents learning procedures to experienced practitioners needing a quick refresher, will find this book, along with its companion volume, Neurosurgery Tricks of the Trade: Spine and Peripheral Nerves, to be an invaluable resource throughout their surgical careers"--Provided by publisher.

Summary: This book provides a modern and up to date overview of the evaluation and management of sports-related neuro trauma. The primary target audience is the "sports neurosurgeon," who can be found on the sidelines of collision sports at all levels of play from high school to professional, or who may care for these athletes in the acute setting in hospital or the outpatient clinics. The reach of this book, however, will also extend to professionals in other fields of medicine due to some topics that extend outside the typical neurosurgical specialty, ranging from chiropractic care in the evaluation and treatment of elite athletes to alternative medical therapies for concussion. The importance of the emerging "sports neurosurgeon" subspecialty is exemplified by the adoption of a policy by the National Football League to require an Unaffiliated Neurotrauma Consultant on-field for player safety. This policy also speaks to the recent public awareness of the importance of recognizing and treating sports-related neuro trauma. This text aims to capitalize on this trend and become a multi-specialty reference to anyone interested in the field. Neurosurgical Care of Athletes serves as a comprehensive resource for physicians and researchers involved in sports-related neuro trauma. All chapters are prepared by experts in their fields and include the most up to date scientific and clinical information.

Contents:
1. Pre-participation screening for the sports neurosurgeon
2. On Field Assessment of the Athlete
3. Spinal Injury in Athletes: Prevalence and Classification
4. Neurosurgical Management of Spinal Cord Injuries in Athletes
5. Evaluation and Management of Cervical Radiculopathy in Athletes
6. Return to Play After Spinal Injury
7. Chiropractic- An Integrative Approach to the Evaluation and Treatment of Elite Athletes utilizing Spinal Manipulation
8. Diagnosis of Sports-related Peripheral Nerve Injury
9. Non-Operative and Operative Management of Sports-Related Peripheral Nerve Injury
10. Concussion in sports: What is it and how is it managed?
11. Sport-related Structural Brain Injury
12. Neuroimaging and Blood Biomarkers of Sport Concussion
13. Active Rehabilitation and Return to Play after Concussion
14. Sports concussions: Is there a role for alternative treatments?
15. Chronic Traumatic Encephalopathy: Past, Present, and Future.

Summary: "Written by neurosurgery residents for neurosurgery residents and other providers, The Neurosurgical Consult Book focuses on the initial care and treatment of the neurosurgical consult patient, providing the key guidance you need when quick clinical management decisions are critical. You will learn to recognize the acuity of patient presentation and determine how to immediately triage the needs of the patient at an appropriate level of care. This portable, practical guide helps you quickly steer neurosurgical patients to medical stability and safety until a definitive treatment plan is implemented"-- publisher's description.

Summary: "Evidence-based neurosurgery is one of the most important pillars upon which to build decision management pathways. Effective delivery of care involves understanding the natural history of the disease and the evidence behind available treatment options. Neurosurgical Diseases: An Evidence-Based Approach to Guide Practice by esteemed neurosurgeons Leon T. Lai, Cristian Gragnaniello, and expert contributors covers cranial pathologies neurosurgeons commonly encounter in everyday practice"-- Provided by publisher.

Summary: Good neurosurgical practice is based not only on evidence, skills, and modern equipment, but also on good values. Young surgeons often learn about ethical behavior by observing the behavior of their teachers in different situations, but for several reasons, this is not enough. This book discusses the ethical issues that arise during the daily practice of neurosurgery. It will be especially informative for neurosurgeons, other surgeons, physicians, residents, medical students, and allied health care providers. The book is not a philosophical expose but an easily readable and highly practical road map on how to navigate ethically challenging situations in neurosurgical and other practice. The book is divided into five parts addressing general issues, patients' rights, end of life issues, neurosurgeons' duties, and neurosurgeons and society. The contributing authors are well-established neurosurgeons and other doctors with long experience and from different backgrounds. They discuss ethical problems encountered in everyday practice, introduced by cases, and in all, there are more than 50 neurosurgical cases drawn from real life. The editors introduce in the title and throughout the book the term 'value-based medicine' which reinforces that while modern medicine and surgery have come very far in technical aspects, the core of what we do must be based on the values embodied in bioethics.

Contents:
Brief History of Bioethics
Ethics Principles and Theories
Cross-Cultural Ethics
Patients' Rights
Informed Consent
Privacy and Confidentiality
Severe Neurosurgical Conditions in Children
End-of-Life Care
Dying with Dignity
Brain Death
Neurosurgeons' Duties
Ethical Decision-Making
Errors
Workplace Ethics and Professionalism
Neurosurgical Innovation
Research Ethics
Consent in Emergency Clinical Research
Neuroethics
Training of Neurosurgeons
Conflict of Interest
Priority Setting
Medicolegal Issues
Neurosurgeons and the Media
International Neurosurgery Collaborations.

Contents:
Immunology of the CNS / Pragati Nigam and Maciej Lesniak
Microbiological diagnosis of CNS / Yuriko Fukuta and Karin E. Byers
Antibiotics and development of resistance / Peter D. Kim and Walter A. Hall
Radiology of infections of the CNS / Kunal M. Patel and Charles L. Truwit
Viral infections of the CNS
Joseph B. Domachowske and Manika Suryadevara
Fungal infections of the CNS / Walter A. Hall and Peter D. Kim
Parasitic infections of the CNS / Ali Akhaddar and Mohamed Boucetta
Bacterial brain abscess / Peter D. Kim and Walter A. Hall
Meningeal infections / Manika Suryadevara and Joseph B. Domachowske
Epidural and subdural infections / Sandi K. Lam and Peter C. Warnke
Intracranial vascular infections / Hoon Choi, Walter A. Hall, and Eric M. Deshaies
Vertebral column infections / Kyle I. Swanson and Daniel K. Resnick
Spinal canal infections / Ian E. McCutcheon
Neurosurgical antibiotic prophylaxis / DaraspreetKainth, Dino Terzic, and Stephen J. Haines
Postoperative intracranial infections / Arya Nabavi, Friederike Knerlich-Lukoschus, and Andreas M. Stark
Implanted devices and CNS infection / Ramesh Grandhi, Gillian Harrison, and Elizabeth C. Tyler-Kabara
Pediatric CNS infections / Ian Mutchnick and Thomas Moriarty
Immune compromise and CNS infections / Ouzi Nissim ... [et al.]
Systemic infections in neurocritical care / Michael F. Regner ... [et al.].

Contents:
Bedside neurologic exam / Robert Dahlin, Dan E. Miulli, and Javed Siddiqi
Altered mental status and coma: pathophysiology and management / Jason Duong, Shokry Lawandy, Jeffery M. Jones, Dan E. Miulli, and Javed Siddiqi
Neuroimaging and the neurosurgical intensive care unit patient / Christopher Elia, Blake Berman, and Dan E. Miulli
Diagnostic laboratory studies in the ICU patient: what, when, and how often? / John Ogunlade, Dan E. Miulli, and Jon Taveau
Team management of the multisystem-injured neurosurgical intensive care unit patient / Mark Krel, Javed Siddiqi, Silvio Hoshek, Rosalinda Menoni, Vladimir Adriano Cortez, Jeff W. Chen, and David T. Wong
The spinal cord injury patient / Christopher Elia, Blake Berman, Jeffery M. Jones, Shokry Lawandy, Yancey Beamer, and Dan E. Miulli
Delayed intracerebral hemorrhage / Tyler Carson, Marc Billings, Todd M. Goldenberg, Vladimir Adriano Cortez, and Dan E. Miulli
Sedation and pain management in the neurosurgical intensive care unit patient / Gohar Majeed and Dan E. Miulli
Homeostatic mechanisms in the neurosurgical intensive care unit patient / Jerry Noel, Dan E. Miulli, Gayatri Sonti, and Javed Siddiqi
Neurophysiology in the neurosurgical intensive care unit: options, indications, and interpretations / Tyler Carson, Dennis Cramer, and Dan E. Miulli
Cerebral perfusion / Deependra Mahato, Kevin Roy, Dan E. Miulli, and Javed Siddiqi
Cerebrospinal fluid dynamics and pathology / Deependra Mahato, Kevin Roy, John D. Cantando, Dan E. Miulli, and Javed Siddiqi
Intracranial pressure fundamentals / Tyler Carson, Dan E. Miulli, and Javed Siddiqi
Cerebral protection measures / Tyler Carson, Dennis Cramer, Dan E. Miulli, and Javed Siddiqi
Neuropharmacology / John Ogunlade, Nicholas Qandah, and Dan E. Miulli
Nutrition / Jerry Noel, Silvio Hoshek, Rosalinda Menoni, and Dan E. Miulli
Fluid management / Samir Kashyap, Robert Dahlin, Raed Sweiss, James Berry, and Dan E. Miulli
Ventilator management / Justen Watkins, Dan E. Miulli, James Berry, Glenn Fischberg, and Javed Siddiqi
Seizure disorders: diagnosis and management / Vivek Ramakrishnan, Margaret Wacker, Dan E. Miulli, and Glenn Fischberg
Infections / Marc Cabanne and Dan E. Miulli
Cerebral microdialysis in the neurosurgical intensive care unit / Jeff W. Chen, Daniella Abrams-Alexandru, and Javed Siddiqi
Anticoagulation and antiplatelet therapy in the neurosurgical intensive care unit / Bo-Lin Liu, and Javed Siddiqi
Restraints in the neurosurgical intensive care unit patient / Colleen Rose and Justen Watkins
Unique pediatric neurosurgical intensive care unit issues / Tanya Minasian, Daniel J. Won, and Dan E. Miulli
Systemic complications and disease-specific phenomena leading to ischemic injury / Hammad Ghanchi and Dan E. Miulli
Acute ischemic stroke / Robert J. Claycomb, Luis T. Arangua, Vladimir Adriano Cortez, Glenn Fischberg, and Javed Siddiqi
Brain death / Omid R. Hariri and Dan E. Miulli
Family communication / Mark Krel and Dan E. Miulli
Spiritual care of the neurosurgical intensive care unit patient and family / John Spitalieri, Marc Billings, and Javed Siddiqi
Medical-legal issues in the neurosurgical intensive care unit / Bailey Zampella, Dan E. Miulli, Silvio Hoshek, Rosalinda Menoni, and Yancey Beamer
Discharge planning for the neurosurgical intensive care unit patient / Dan E. Miulli, Jacob Bernstein, and Paula Snyder.

Contents:
1. Intracranial monitoring techniques
2. The stereoelectroencephalography technique and methodology
3. Surgical anatomy of the temporal lobe
4. Tailored and standard temporal lobectomy
5. Selective amygdalohippocampectomy
6. Surgical treatment of extratemporal epilepsy
7. Magnetic resonance imaging-guided stereotactic laser ablation for epilepsy
8. Hypothalamic hamartomas
9. Anatomic hemispherectomy
10. Peri-insular hemispherotomy
11. Multiple subpial transections and multiple hippocampal transections for epilepsy in eloquent brain areas
12. Technical aspects of callosotomy
13. Responsive neurostimulation for th treatment of epilepsy
14. Deep brain stimulation of anterior thalamic nuclei for epilepsy
15. Vagus nerve stimulation for intractable epilepsy
16. Frame-based stereotactic DBS implantation of vim for essential treamor and other cerebellar outflow tremors
17. Chronic subthalamic nucleus stimulation for Parkinson's Disease
18. Frame-based globus pallidus deep brain stimulation for Parkinson's Disease or dystonia
19. Interventional MRI-guided deep brain stimulator implantation
20. Frameless DBS implantation with the O-arm
21. DBS implnatation with 3D-printed stereotactic platforms and the cranial vault probabilistic atlas
22. Frameless and frame-based lead implantation in computed tomography scanner
23. Ablative procedures for movement disorders: pallidotomy
24. Stereotactic surgery for obsessive-compulsive disorders and Tourette Syndrome
25. Stereotactic surgery for depression
26. Pediatric functional neurosurgery
27. Radiosurgery for functional neurosurgical procedures
28. MVD and open rhizotomy for cranial neuralgias
29. Stereotactic radiosurgery for trigeminal neuralgia
30. Percutaneous ablative treatment of neuropathic facial pain
31. Dorsal root entry zone: spinal cord
32. Dorsal root entry zone: nucleus caudalis
33. Open surgical and percutaneous radiofrequncy cordotomy
34. Peripheral nerve stimualation for pain relief: primer on occipital nerve stimulation
35. Spinal nerve root and dorsal root ganglion stimulation
36. Neurosurgical interventions for neuropathic craniofacial pain
37. Implantation of a spinal cord stimulator for pain relief
38. Motor cortex stimulation for the treatment of noncancer chronic pain
39. Deep brain stimulation for medically intractable pain syndromes
40. Sympathectomy
41. Interventional pain management techniques for low back pain
42. Pumps for pain and spasticity
43. Treatment of idiopathic intracranial hypertension and normal pressure hydrocephalus with cerebrospinal fluid shunt implantation
44. Trigeminal ganglion stimulation.

Contents:
Peripheral nerves
Spine and spinal cord
Vascular
Oncology (brain)
Head injury
Pediatric neurosurgery
Functional neurosurgery
Other diseases
Anatomy
Surgical procedures
Surgical complications
Neurology for neurosurgeons.

Summary: "This book reviews the scientific literature and the authors' own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer's disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum's complex speciation chemistry in relation to biology, and details aluminum's mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal's debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity"--Publisher's description.

Contents:
Overview of the relationship between aluminum exposure and health of human being / Qiao Niu
The chemistry of human exposure to aluminium / Christopher Exley
Entry and deposit of aluminum in the brain / Linping Wang
Aluminum as a CNS and immune system toxin across the life span / Christopher A. Shaw
Occupational exposure to aluminum and cognitive impairment / Xiaoting Lu
Exposure to aluminum in daily life and Alzheimer's disease / Jisheng Nie
Animal model of aluminum-induced Alzheimer's disease / Jing Song
Aluminum-induced neural cell death / Qinli Zhang
Aluminum-induced electrophysiological variation, synaptic plasticity impairment, and related mechanism / Huifang Zhang
Cross talk between aluminum and genetic susceptibility and epigenetic modification in Alzheimer's disease / Ruifeng Liang.

Contents:
From the contents: Preface
ADHD Modeling by Perinatal Insult in Animals
Perinatal Insults to Model Human Neuro-Psychiatric Disorders
Selective Life-long Destructive of Brain Monoaminergic Nerves
NGF in Perinatal Development
Life-long Susceptibility Consequent to Perinatal Substances of Abuse
Schizotypic Effects of Perinatal Insults.

Summary: A host of neurotransmitters and neuroactive substances underlies respiratory regulation in health and disease. The centerpiece of investigations regarding adaptation to hypoxia and sensorial perception has been the dopaminergic system. It is now clear that a complex interaction among various neuroactive substances, rather than a single one, forms the basis of respiratory changes. The research on neurotransmitter interactions provides the knowledge of how the brain functions and a new level of understanding of mind-to-body connection, which opens up avenues for novel therapeutic interventions.

Contents:
Inherited Disorders of Brain Neurotransmitters: Pathogenesis and Diagnostic Approach
Inhibition of Peripheral Dopamine Metabolism and the Ventilatory Response to Hypoxia in the Rat
Adaptation of Olfactory Threshold at High Altitude
Guanosine Protects Glial Cells against 6-Hydroxydopamine Toxicity
Chemoresponsiveness and Breath Physiology in Anosmia
Cognitive Functioning of the Prelingually Deaf Adults
Hypoxia-Related Brain Dysfunction in Forensic Medicine
Does Health Status Influence Acceptance of Illness in Patients with Chronic Respiratory Diseases?.

Summary: Neurotrauma in Multiple Choice Questions is the FIRST review book to use the multiple-choice question format in neurosurgical trauma. Students of neurosurgery, the resident, the fellow, the younger neurosurgeon preparing for exams or practice, and even the later stage neurosurgeon are the target audience of this book. The information in this work is in accordance with the most up-to-date best practice evidence, with a style that mirrors the format adopted by the majority of local, regional, and international board examinations. The strategy and format of the questions provide a stepwise progression from definition to surgical decision-making, to a comprehensive and concise overview of neurological trauma.

Contents:
Section 1: Cranial Neurotrauma
Chapter1: Principles, and initial assessment
Chapter2: Management
Chapter3: Complications, outcome and other aspects
Section 2: Spinal Neurotrauma
Chapter4: Principles, and initial assessment
Chapter5: Management
Chapter6: Complications, outcome and other aspects
Section 3: Peripheral Neurotrauma and Miscellaneous issues
Chapter7: Peripheral nerves Neurotrauma
Chapter8: Miscellaneous issues related to Neurotrauma.

Contents:
Neurotrauma and Critical Care of the Brain
Title Page
Copyright
Contents
Foreword
Preface
Contributors
Part I: Introduction
1. Brain Trauma and Critical Care: A Brief History
2. The Epidemiology of Traumatic Brain Injury in the United States and The World
3. The Classification of Traumatic Brain Injury
Part II: Science
4. Pathophysiology of Traumatic Brain Injury
5. Blood Biomarkers: What is Needed in the Traumatic Brain Injury Field?
6. Noninvasive Neuromonitoring in Severe Traumatic Brain Injury
7. Multimodality Monitoring in Neurocritical Care
8. Brain Injury Imaging
Part III: Management
9. Prehospital Care for Patients with Traumatic Brain Injury
10. Assessment of Acute Loss of Consciousness
11. Guidelines Application for Traumatic Brain Injury
12. Mild Brain Injury
13. Moderate Traumatic Brain Injury
14. Severe Traumatic Brain Injury
15. Wartime Penetrating Injuries
16. Guidelines for the Surgical Management of Traumatic Brain Injury
17. Concomitant Injuries in the Brain-injured Patient
18. Pediatric Brain Injury
Part IV: Critical Care
19. Neurological Critical Care
20. Fluids Resuscitation and Traumatic Brain Injury
21. Sedation and Analgesia in Traumatic Brain Injury
22. Mechanical Ventilation and Pulmonary Critical Care
23. Nutrition Support in Brain Injury
24. Cardiovascular Complications of Traumatic Brian Injury
25. Paroxysmal Sympathetic Hyperactivity
26. Venous Thromboembolism Prophylaxis in the Neurocritical Care Population
27. Traumatic Brain Injury and Infection
28. Targeted Temperature Management in Acute Traumatic Brain Injury
Part V: Outcome
29. Neurorehabilitation after Brain Injury
30. Prognosis for Traumatic Brain Injury
Part VI: Socioeconomics
31. Ethics: Life and Death Choices for Traumatic Brain Injury
32. Cost of Traumatic Brain Injuries in the United States and the Return on Helmet Investments
Index

Contents:
Epidemiology of spinal injuries / Basheer A. Shakir, Ignacio Jusue-Torres, and Howard B. Levene
Pathophysiology of spinal cord injury / Basheer A. Shakir and Howard B. Levene
Spinal cord protective and regenerative therapies / Ahad M. Siddiqui, Chris S. Ahuja, Charles H. Tator, and Michael G. Fehlings
Spinal trauma classification systems / Jefferson R. Wilson and Srinivas Prasad
Imaging of spinal injuries / Paul D. Campbell Jr., Yehuda Kerbel, William B. Morrison, and John A. Carrino
Biomechanics of the spine / Nina Z. Moore, Assem A. Sultan, and Edward C. Benzel
Neurological assessment of spinal injury / Ralph J. Marino
Prehospital care for spinal cord injury / Geoffrey Stricsek, Paul Park, Kevin T. Foley, and Joshua Heller
Clearing the cervical spine / Daniel G. Tobert and Mitchel B. Harris
Surgical decompression in traumatic spinal cord injury : the importance of timing / Allan Levi and Shelby Burks
Management of cervical injuries / Sander P.J. Muijs and F.C. Oner
Thoracolumbar fractures / Joost P.H.J. Rutges and Marcel Dvorak
Management of concurrent traumatic brain injury and spinal injury / Eli M. Baron, Paula Eboli, and Doniel Drazin
Spinal cord injuries in the athlete / Gregory D. Schroeder, Andrew R. Helber, Douglas A. Hollern, and Alexander R. Vaccaro
Critical care management of spinal cord injuries : mean arterial pressure control and hypertonic therapy / Courtney Pendleton, Rani Nasser, Matthew Vibbert, and Jack Jallo
Targeted temperature management in spinal cord injury / Jacqueline Kraft, Anna Karpenko, and Fred Rincon
Comprehensive review of spinal cord injury pharmacology and recent medical advances in treatment / John Gillick and Srinivas Prasad
Autonomic dysreflexia / Mohan Kottapally and Kristine H. O'Phelan
Infections after spinal cord injury / Amandeep S. Dolla and M. Kamran Athar
Emerging therapies for spinal cord injury / Richard F. Schmidt, George M. Ghobrial, and James S. Harrop
Rehabilitation of traumatic spinal cord injury / Mendel Kupfer, Matthew Sonagere, and Christopher Formal
Socioeconomics of spinal injuries / Jeffrey A. Rihn, Zachary T. Wilt, Rob D. Dickerman, Michael O'Malley, and Jack E. Zigler
Quality of life after spinal cord injury / John Cheng, Sarah Durante, Christopher Formal, and Guy Fried.

Summary: This text addresses many of the questions which occur when medical professionals of various disciplines interact and have different plans and interventions, each with its own valid scientific and/or experience-based rationale: Questions involving tourniquet placement, ideal fluids and volumes for resuscitation, VTE prophylaxis and many other management considerations. Straightforward decisions in the patient with a single diagnosis often conflict when applied to the neurologically injured polytrauma patients. Neurotrauma Management for the Severely Injured Polytrauma Patient answers as many of these questions as possible based on the current literature, vast experience with severe neurotrauma in the current conflicts in Afghanistan and Iraq, and the experience of trauma experts across the globe as well as proposes areas for future study where answers are currently less clear. .

Contents:
The Difficult Conversation
Communication Between Teams and Multidisciplinary Rounds and Single Primary POC for Family Communication
Lessons Learned and Who's in Charge?
Mass Casualty Events and Your Hospital
Rural and Austere Environments
Prehospital Care and EMS Considerations in the Polytrauma Patient with CNS Injuries
AIS vs. ISS vs. GCS ? What?s Going On Here?
Trauma Resuscitation and Fluid Considerations in the Polytrauma Patient with CNS Injury
Initial Imaging Considerations, Repeat Imaging Frequency
Evidence Based Review of the Use of Steroids in Neurotrauma
Interventional Radiology in the Civilian Neurotrauma Setting
Vertebral artery injuries in penetrating neck and cervical spine trauma
Clearing the Cervical Spine in Blunt Trauma
Initial evaluation and management
Transport of the Neurotrauma Patient
Multiple Surgical Teams in the O. R. at Once ? Priority of Effort and Who Takes the Lead?
Laparotomy for refractory ICP
Associated Musculoskeletal Injuries
Neuro Anesthetic Considerations
Decompressive Craniectomy for Severe TBI
Hemodynamic Considerations in the Polytrauma Patient with Traumatic Brain Injury (TBI)
Coagulopathy in Traumatic Brain Injury
Venous Thromboembolism Prophylaxis
Mechanical Ventilation in Traumatic Brain Injury
Nutrition, Antibiotics, and Posttraumatic Seizure Prophylaxis
Therapeutic Hypothermia for Traumatic Brain Injury and Spinal Cord Injury
Rehabilitation in the setting of Neuro-Trauma
Craniofacial Reconstruction in the Polytrauma Patient
Functional Restoration for Neurological Trauma: Current Therapies and Future Directions
Pediatric Neurotrauma
Care of Patients with Burns and Traumatic Brain Injury.

Summary: This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington's syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Summary: This book introduce neurourology as an emerging interdisciplinary area that covers the basic and clinical studies of the neural control on the normal lower urinary tract and the lower/upper urinary tract dysfunction due to neuropathy disorders. It systematically describes all aspects of neurourology from the epidemiology of the neurogenic bladder; to the pathology and pathophysiology of the lower urinary tract; to the diagnosis and treatment of the neurogenic bladder by conservative therapies or surgeries. This book provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions. All the topics are written by internationally recognized specialists in their field. Editor Limin Liao is Professor and Director of the Department of Urology, China Rehabilitation Research Center, affiliated to Capital Medical University, China. Prof. Helmut Madersbacher is a Professor of Urology and em.Head of the Neurourology Unit of the University Hospital, Innsbruck, Austria.

Summary: "This book employs a cased-based format similar to the earlier Krings book, Case-Based Interventional Neuroradiology. After describing a clinical scenario the relevant anatomic structure or variation will be described and explained (embryological background) and its impact on treatment decisions and treatment modalities are explained. Potential complications that may arise if not properly recognized are indentified. Images of other similar cases are added to show the spectrum of the anatomy and its variations. References to the pertinent literature are provided for each case. Cases are grouped to allow for smooth reading cover to cover and at the same time to quickly get one up to speed prior to performing a procedure where one encounters a similar variation. Imaging includes conventional angiography but will also include MR/MRA and CT/CTA when appropriate"--Provided by publisher.

Summary: This book contains articles presented at the 12th International Conference on Cerebral Vasospasm, held in Lucerne, Switzerland, in July 2013. The included papers represent a balanced cross-section of the enormous progress achieved in basic and clinical research on aneurysmal subarachnoid hemorrhage and its sequelae, including early neurovascular events and delayed cerebral vasospasm. The section on basic research covers a broad range of aspects, from pathophysiology and neuroprotection in early brain injury through to macro- and microcirculatory disturbances, inflammation and blood-brain barrier disruption, spreading depolarization, and the role of nitric oxide. There is a special focus on animal models for the study of acute events after experimental subarachnoid hemorrhage. The section on clinical topics encompasses imaging and endovascular management, surgical innovations and techniques, management and monitoring in neurocritical care, the status of clinical trials, and factors involved in aneurysm formation. This edition is of interest not only for basic researchers but also for clinicians who wish to apply state-of-the-art knowledge to the research and management of this devastating condition.

Contents:
Basic Research Topics: Early Brain Injury: Pathophysiology
Early Brain Injury: Neuroprotection
Macro- and Microcirculatory Disturbance
Inflammation and Blood-Brain-Barrier Disruption
Spreading Depolarization: From Bench to Bedside and Back
Nitric Oxide: From Bench to Bedside. Clinical Topics: Imaging and Endovascular Management
Treatment: Surgical Innovations and Techniques
Neurocritical Care: Management
Neurocritical Care: Monitoring
Clinical Trials: Current Status and the Way forward
Aneurysm Formation: Morphology, Environment, and Genetics.

Summary: "The Neurovascular Nursing: Scope and Standards of Practice is an essential document for every Neurovascular nurse practicing in the United States. The scope of practice statement answers the who, what, when, where, how, and why questions of neurovascular nursing. The standards provide authoritative statements of the actions and behaviors that all registered neurovascular nurses are expected to competently perform, regardless of role, population, specialty, and setting. The product of extensive thought work by many registered nurses, this new edition provides 18 national standards of practice and professional performance. Each standard is accompanied by detailed competencies for the three practice levels. This premier professional resource informs and guides Neurovascular nurses in their vital work providing safe, quality, and competent care. It is a must-have for every registered neurovascular nurse"--Publisher's description.

Contents:
Neurovascular Nursing
Introduction to Neurovascular Nursing Practice : Foundational Documents of Professional Nursing ; Audience for this Publication
Scope of Neurovascular Nursing Practice : Definition of Neurovascular Nursing ; Integrating the Science and Art of Neurovascular Nursing ; Neurovascular Disease ; Characteristics of Neurovascular Nursing ; Roles, Education, and Settings in Neurovascular Nursing Practice ; Societal and Ethical Dimensions of Neurovascular Nursing ; The How of Neurovascular Nursing ; The Future of the Neurovascular Nursing Specialty ; Direction for Neurovascular Nursing Practice ; Summary of the Scope of Neurovascular Nursing Practice ; Neurovascular nursing practice and the Association of Neurovascular Clinicians
Standards of Neurovascular Nursing Practice and Professional Performance. Competency as a function of standards
Standards of Neuovascular Nursing Practice : Standard 1. Assessment ; 2. Diagnosis ; Standard 3. Outcomes Identification ; Standard 4. Planning ; Standard 5. Implementation ; Standard 5a. Coordination of care ; Standard 5b. Health teaching and health promotion ; Standard 6. Evaluation
Standards of Professional Performance : Standard 7. Ethics ; Standard 8. Advocacy ; Standard 9. Respectful and equitable practice ; Standard 10. Communication ; Standard 11. Collaboration ; Standard 12. Leadership ; Standard 13. Education ; Standard 14. Scholarly Inquiry ; Standard 15. Quality of practice ; Standard 16. Professional practice evaluation ; Standard 17. Resource steardship ; Standard 18. Environmental health
Appendices: ANVC Leadership Framework : Clinical localization assesment by vascular territoy.

Summary: This book provides a comprehensive and concise, review of the fundamental concepts and clinical indications for Transcranial Doppler (TCD) imaging. An overview of the physics of ultrasonography as it pertains to TCD is presented, as well as neuroanatomy and cerebrovascular physiology in healthy and diseased states. Recommended protocols for neuroimaging are reviewed and serves as a guide for existing neurovascular laboratories and medical systems seeking to develop laboratories that are in need of a guide to establish their own protocols. The most common, relevant and challenging clinical conditions where TCD is incorporated to assist with patient management are discussed. In addition, chapters provide a framework for building a neurovascular laboratory, including necessary equipment, steps to obtain national accreditation by accrediting bodies, and reimbursement procedures for tests performed. The book concludes with "clinical pearls" and "tricks of the trade", which serve as a commentary to guide physicians and neurosonologists on best-practices for TCD acquisition and interpretation.

Contents:
Principles of Transcranial Doppler Sonography
Overview of Pertinent Cerebral Vascular Anatomy
Cerebral Waveforms for Hemodynamic assessment
Monitoring in Neurocritical Care – Overview
Transcranial Doppler in Subarachnoid Hemorrhage
Reversible Cerebral Vasoconstriction Syndrome (RCVS) and Vasculitis
MONITORING FOR EMBOLI DETECTION (without and with MICROBUBBLES)
EVALUATION OF CEREBRAL CIRCULATORY ARREST
Intracranial Stenosis
Therapeutic TCD for patients with acute cerebral ischemia
Clinical Application of Cerebrovascular Physiology
Adult Traumatic Brain Injury
Traumatic Brain Injury : Pediatric
Cerebrovascular Reactivity Assessments in Traumatic Brain Injury
Transcranial Doppler Protocols and Procedures: Vasomotor Reactivity
Continuous Cerebral Autoregulation Monitoring using TCD
Optic Nerve Sheath Diameter for Increased Intracranial Pressure
Cranial Ultrasound
Applications of Transcranial Doppler Ultrasonography in Sickle Cell Disease, Stroke, and Critical Illness in Children
Point of care Transcranial Doppler
CEREBROVASCULAR PHYSIOLOGY IN THE SETTING OF TEMPORARY AND DURABLE MECHANICAL CIRCULATORY SUPPORT
Electroencephalography versus Transcranial Doppler Ultrasonography; Indications and Applications for Intracranial Monitoring
Moyamoya Disease
Vertebral Steal
Transcranial Doppler in Acute Bacterial Meningitis
TCD equipment, Lab Accreditation, Reimbursement, and Practice Issues
Use of Transcranial Doppler in the Outpatient Ultrasound Lab
Protocol for Non- Imaging Transcranial Doppler
Transcranial Color Doppler Imaging for Adults
Protocol for Monitoring for Emboli Detection (and with Microbubbles)
How to obtain measurements of the optic nerve sheath diameter in adults and children utilizing point-of-care ophthalmic ultrasonography
Protocol for Extracranial Carotid Exam.

Summary: "The complex, highly technological field of neurovascular surgery is quickly expanding, encompassing traditional surgical approaches, as well as endovascular and neurointerventional techniques. The last decade has seen increased cross-specialty interest in utilizing minimally invasive techniques to help prevent and treat cerebrovascular disease. Concurrently, there has been important research analyzing the efficacy of surgical methods versus endovascular approaches and the clip versus coil discussion is covered herein. Written by 21st Century pioneers in the field, this second, cutting-edge edition offers the latest science throughout 1,400 pages and a remarkable video library covering anatomy, diagnosis, epidemiology, history, treatment indications, technical nuances, outcomes, and complications. Internationally renowned experts from across the globe share clinical pearls and best practices, from the research lab to the ER to the OR. Medical, surgical, endovascular, cerebral revascularization, bypass surgery, radiation therapy, and other procedures are covered in depth. Evidence-based and transdisciplinary, the second edition covers the full spectrum of neurovascular pathologies, preoperatively and postoperatively, including: Ischemic Stroke and Vascular Insufficiency, Cerebral and Spinal Aneurysms, Cerebral Spinal Arteriovenous Fistulae and Malformations, Vascular Tumors, Carotid Artery Disease, Moya-Moya Disease. Organized into 11 primary sections, 99 richly illustrated chapters, and more than 140 videos, this volume is an invaluable, one-stop reference tool. It is a must-have for general, vascular and endovascular neurosurgeons; interventional radiologists; neurologists; critical care practitioners; and neuro-rehabilitation specialists"--Provided by publisher.

Summary: This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere.

Contents:
Chapter One: Fundamentals of neutron crystallography in structural biology
Chapter Two: Large crystal growth for neutron protein crystallography
Chapter Three: Prospects for membrane protein crystals in NMX
Chapter Four: IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor
Chapter Five: The macromolecular neutron diffractometer at the spallation neutron source
Chapter Six: Current status and near future plan of neutron protein crystallography at J-PARC
Chapter Seven: Neutron macromolecular crystallography at the European spallation source
Chapter Eight: Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals
Chapter Nine: Implementation of the riding hydrogen model in CCTBX to support the next generation of X-ray and neutron joint refinement in Phenix
Chapter Ten: Interactive model building in neutron macromolecular crystallography
Chapter Eleven: What are the current limits on determination of protonation state using neutron macromolecular crystallography?
Chapter Twelve: Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease
Chapter Thirteen: Neutron crystallographic studies of carbonic anhydrase
Chapter Fourteen: Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons
Chapter Fifteen: Pyridoxal 5′-phosphate dependent reactions: Analyzing the mechanism of aspartate aminotransferase
Chapter Sixteen: The role of hydrogen atoms in redox catalysis by the flavoenzyme cholesterol oxidase
Chapter Seventeen: Heme peroxidase—Trapping intermediates by cryo neutron crystallography.

Contents:
The role of neutrophils in the immune system : an overview / Harry L. Malech, Frank R. DeLeo, and Mark T. Quinn
Isolation of human neutrophils from venous blood / William M. Nausef
Neutrophil isolation from nonhuman species / Daniel W. Siemsen ... [and 7 others]
Collection of in vivo transmigrated neutrophils from human skin / Karin Christenson ... [and 6 others]
Subcellular fractionation of human neutrophils and analysis of subcellular markers / Stine Novrup Clemmensen, Lene Udby, and Niels Borregaard
Rho family and Rap GTPase activation assays / Richard T. Jennings and Ulla G. Knaus
Measurement of phospholipid metabolism in intact neutrophils / Susan Sergeant and Linda C. McPhail
Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils / Maurice B. Hallett, Maha Al-Jumaa, and Sharon Dewitt
Analysis of electrophysiological properties and responses of neutrophils / Deri Morgan and Thomas E. DeCoursey
Assessment of neutrophil apoptosis / David A. Dorward ... [and 3 others]
Microinjection methods for neutrophils / Iraj Laffafian ... [and 3 others]
Generation of functionally mature neutrophils from induced pluripotent stem cells / Colin L. Sweeney ... [and 6 others]
Neutrophil migration through extracellular matrix / Richard T. Jennings and Ulla G. Knaus
Spinning disk confocal imaging of neutrophil migration in zebrafish / Pui-Ying Lam ... [and 4 others]
Detection of bidirectional signaling during integrin activation and neutrophil adhesion / Stuart M. Altman, Neha Dixit, and Scott I. Simon
Immunofluorescence and confocal microscopy of neutrophils / Lee-Ann H. Allen
Expressin of genetically encoded fluorescent probes to monitor phospholipid dynamics in live neutrophils / Benjamin E. Steinberg, Marco A.O. Magalhaes, and Sergio Grinstein
Quantitative assessment of neutrophil phagocytosis using flow cytometry / Pontus Nordenfelt
Analysis of neutrophil bactericidal activity / Heather A. Parker ... [and 4 others]
Induction and quantification of neutrophil extracellular traps / Alejandro Sanchez Gonzalez ... [and 3 others]
Measurement of respiratory burst products, released or retained, during activation of professional phagocytes / Johan Bylund ... [and 4 others]
Cell-free NADPH oxidase activation assays : "In vitro veritas" / Edgar Pick
Assessment of priming of the human neutrophil respiratory burst / Margarita Hurtado-Nedelec ... [and 4 others]
Affinity pruification and reconstitution of human phagocyte flavocytochrome b for detection of conformational dynamics in the membrane / Marcia Riesselman and Algirdas J. Jesaitis
Evaluation of p47phox phosphorylation in human neutrophils using phospho-specicfic antibodies / Sahra Amel Belambri, Pham My-Chan Dang, and Jamel El-Benna
Genome-scale transcript analyses with human neutrophils / Scott D. Kobayashi, Daniel E. Sturdevant, and Frank R. DeLeo
Fast and accurate quantitative analysis of cytokine gene expression in human neutrophils / Nicola Tamassia, Marco A. Cassatella, and Flavia Bazzoni
High-purity neutrophil isolation from human peripheral blood and saliva for transcriptome analysis / Flavia S. Lakschevitz and Michael Glogauer
Detection of intact transciption factors in human neutrophils / Patrick P. McDonald and Richard D. Ye
Disorders of neutrophil function : an overview / Mary C. Dinauer
Diagnostic assays for chronic granulomatous disease and other neutrophil disorders / Houda Zghal Elloumi and Steven M. Holland
Diagnostic assays for myeloperoxidase and myeloperoxidase deficiency / William M. Nauseef.

Summary: Importance of herbs (medicinal plants) can hardly be overemphasized. They are exploited for manyfold applications, ranging from phytopharmaceuticals, to nutraceuticals, to cosmetics and many others. Keeping in view the richness of herbs and their vast potential, this book collates the most up-to-date knowledge of important herbs and herbals. The book also gives an overview of some issues causing hindrance in the promotion of herbals. This book attempts to compile the rich experience of experts working on various herbs. New age single plant species, having multiple medicinal traits worth exploiting i.e. Hippophae rhamnoides (seabuckthorn), and Morinda citrifolia (noni) also find place as full chapters in the book.

Contents:
Intro; Foreword; Preface; Acknowledgements; Contents; Introduction; Commonly Used Herbs; Herbs Availability; Conservation Strategy; Cultivation; Herbal Science; Herbal/Botanicals; Alkaloids; Glycosides; Polyphenols; Terpenes; Research Hurdles in Phyto-medicines; Constraints Associated with the Dealing of Herbal Medicines; Cosmeceuticals; Nutraceuticals; India New Age Herbal Potential; National Policy; The Book Coverage; Further Readings; Part I: New Age Medicinal Plants; Research and Development on Artemisia annua in India; Introduction; In planta Artemisinin Biosynthesis. Feel-Good FactorsCultivation of Sea Buckthorn; Soil and Climate; Varieties; Propagation; Seeds; Suckers; Stem Cuttings; Hard Wood; Soft Wood; Planting and Care; Pruning and Training; Insect Pests; Diseases; Yields; Post-Harvest Management; Commercial Sea Buckthorn Products; Requirements for Promotion of Sea Buckthorn; Summary; References; Noni (Morinda citrifolia L.): Research and Development; Noni Production; Planting Materials Production; Seeds; Planting Season; Pits for Planting; Spacing; Weed Management; Nutrient Management; Irrigation Management; Green Manure Crops; Inter and Mixed Crops. Genetic Resources and Elite Genotypes of A. annuaCharacterization of Genetic Elements from A. annua; Responsiveness of A. annua to Biotic and Abiotic Factors; Other Uses; Some Recent Developments; Societal Impact; Conclusion; References; Indian Sea Buckthorn; Introduction; Authorś Association with Sea Buckthorn; The Shrub; Importance; The Fruit; The Leaf; Traditional Medical Uses; Feed, Fodder, Fuel, and Bio-Fencing; Phytochemicals; Sea Buckthorn Oil; Seed Oil Extraction Techniques; Chemical Profile of Sea Buckthorn Oil; Health Benefits of Sea Buckthorn; Ice Nucleating Agents. Harvest and Postharvest Processing Yield; Storage; References; Rhodiola: An Overview of Phytochemistry and Pharmacological Applications; Introduction; Distribution of Rhodiola Species; Rhodiola rosea; Rhodiola imbricata; Rhodiola heterodonta; Rhodiola crenulata; Rhodiola kirilowii; Rhodiola bupleuroides; Rhodiola dumulosa; Rhodiola algida; Rhodiola sachalinensis; Rhodiola quadrifida; Rhodiola alsi; Chemoprofiling of Rhodiola Species; Rhodiola rosea; Rhodiola imbricata; Rhodiola heterodonta; Rhodiola crenulata; Rhodiola kirilowii; Rhodiola bupleuroides; Rhodiola dumulosa; Rhodiola algida. Rhodiola sachalinensisRhodiola qundrifida; Bioactivity of Rhodiola Species; Rhodiola rosea; Rhodiola imbricata; Rhodiola heterodonta; Rhodiola crenulata; Rhodiola kirilowii; Rhodiola bupleuroides; Rhodiola algida; Rhodiola sachalinensis; Rhodiola qundrifida; In Vitro Propagation/Culture; References; Ophiocordyceps sinensis: The Medicinal Caterpillar Mushroom; Introduction; Taxonomy; Life Cycle of Ophiocordyceps sinensis and Insect Thitarodes armoricanus; Ophiocordyceps Habitat in India; Ethnomycology; Medicinal Uses; Ophiocordyceps Improves the Respiratory Functions.

Summary: "Offers [an] ... interactive program that is designed to help you find meaning and fulfillment in your life while increasing your competency as a leader. It provides a step-by-step, developmental framework for setting goals, building relationships, and using your power and influence to incite positive change"--Amazon.com.

Contents:
Introduction: Welcome to the new alpha movement
Personal excellence. Demonstrate character and ethics
Build positive and productive relationships with others
Prioritize your health and wellness
Develop a mindset for success
Psychological and organizational strategies to help you achieve your goals
Personal leadership. Define your personal leadership identity
Identify your vision
Develop your plan
Execute your plan
Team and organizational leadership. Identify the vision
Develop the plan
Execute the plan
Sustaining progress, growth, and motivation.

Summary: In recent years new, obscure or poorly known dermatological disorders have been described and better defined, with emphasis on clinical, histopathological and etiopathogenetic features. Familiarity with these new, emerging or revisited clinical entities is fundamental, and recognizing them with their differential diagnosis has important implications in clinical practice for better patient management. This book offers an in-depth discussion of the clinical and pathologic features of newly described or less well-known and revisited cutaneous disorders. It provides clinical findings, as well as the histologic, immunologic, and molecular features of these diseases in addition to therapeutic notes. The first section of the book covers cutaneous diseases that lack any systemic implications, such as circumscribed palmoplantar hypokeratosis, necrotizing infundibular crystalline folliculitis, and dermal hyperneury, amongst others. The second section offers coverage on cutaneous diseases with systemic implications, such as AESOP-POEMS syndrome, lipoatrophic panniculitis of children, and obesity associated with lymphedematous mucinosis. Each chapter describes an entity, along with an atlas of clinical manifestations that will serve as a "bed-side" clinical reference, followed by a series of photomicrographs depicting the histologic changes. Chapters also offer recent updates on molecular tools helpful in attaining the diagnosis as well as therapeutic recommendations based upon the more recent acquisitions. New and Emerging Entities in Dermatology and Dermatopathology is a must-have reference for the practicing dermatopathologist, internists, general pathologist reviewing skin biopsies, general dermatologists, family practitioners and nurse practitioners, geneticists, immunologists and other health care providers that care for patients with skin conditions.

Contents:
Part 1. ENTITIES WITHOUT OR LITTLE SYSTEMIC IMPLICATIONS
1.Autoinflammatory Keratinization Diseases
2.Adult Mucinoses: New And Revisited Variants
3.Pediatric Cutaneous Mucinoses
4.Circumscribed Palmoplantar Hypokeratosis
5.Necrotizing Infundibular Crystalline Folliculitis And Necrotizing Eosinophilic Folliculitis
6.Annular Erythema: New And Revisited Variants
7.Frontal Fibrosing Alopecia
8.Terra Firma-Forme Dermatosis And Dermatosis Neglecta
9.Papular Epidermal Nevus With "Skyline" Basal Cell Layer (PENS)
10.Grover Disease
11.The Spectrum Of Acquired Elastolytic Disorders
12.Post Irradiation Pseudo-Sclerodermatous Panniculitis
13.Linear Focal Elastosis And Pxe-Like Fibroelastolytic And Elastotic Papulosis Disorders
14. Rare Variants Of Keratosis Pilaris
15.Cutaneous Collagenous Vasculopathy
16.Acquired Hyperpigmentation Disorders Of Uncertain Etiology
17. Eruptive pseudoangiomatosis, eruptive hypomelanosis and paraviral exanthems
18.Morbihan Disease
Part 2.ENTITIES WITH SYSTEMIC IMPLICATIONS
19.Aquagenic Keratoderma
20.New Or Unusual Skin Manifestations In Monoclonal Gammopathies
21.Lipophagic/Lipoatrophic Panniculitis: A Th1 Mediated Autoimmune Disorder Of The Subcutaneous Fat
22.Covid19-Related Cutaneous Manifestations
23.PAPA, PASH, PAPASH, PsAPASH and PASS: autoinflammatory syndromes of Hidradenitis Suppurativa
24.Re-Emerging And New Skin Infections
25.Skin Adverse Reactions From New Cancer Immunotherapy
26.Newly Recognized Variants Of Neutrophilic Dermatosis
27.Cutaneous Reactive Angiomatoses
28.Skin Manifestations of Immunoglobulin G4-Related Disease
29.Necrolytic Acral Erythema (NAE)
30.Reactive Granulomatous Dermatitis (Interstitial granulomatous dermatitis, palisaded neutrophilic and granulomatous dermatitis, and variants)
31.Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature (CANDLE) and Proteasome Associated Autoinflammatory Syndrome (PRAAS)
32.Spiny Keratoderma
33.Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome
34.Lymphocytic Thrombophilic Arteritis (Macular Lymphocytic Arteritis)
35.Dermal Hyperneury
36.Emergent cutaneous T-cell pseudolymphomas.

Summary: This timely volume serves as a comprehensive and much-needed update to the literature on Latinx health. As both the United States and Latinx subgroups experience and anticipate demographic shifts, it is critical to examine the current epidemiology of Latinx health, as well as the factors influencing this population's health and well-being. Chapters in this book, written by highly respected experts, illuminate the diversity of the Latinx population and provide strategies to mitigate many of the challenges faced by them, including challenges related to migrating to new destinations. The book is designed to enrich dialogue around the multilevel determinants of Latinx health, and concludes with a call to action for both increased culturally congruent and sound Latinx-focused research and the mentorship of Latinx early-career investigators. A selection of the perspectives included among the chapters: Chronic disease and mental health issues in Latinx populations Substance use among Latinx adolescents in the United States Health insurance reform and the Latinx population Immigration enforcement policies and Latinx health Research priorities for Latinx sexual and gender minorities Racial and ethnic discrimination, intersectionality, disability, and Latinx health New and Emerging Issues in Latinx Health is an invaluable compendium that provides a foundation of understanding Latinx health and well-being and guides future research and practice. The book is essential for researchers, practitioners, and students in the fields of public health, health education, population and community health, preventive medicine, health administration and policy, and community and health psychology, and is also relevant for federal, state, and local agencies including health departments and other Latinx- and immigrant-serving community-based organizations.

Contents:
Foreword There are numerous potential candidates for authoring of the Foreword, including but not limited to:Eliseo J. Pérez-Stable, MD, Director of the National Institute of Minority Health and Health Disparities David Hayes-Bautista, MD, PhD, Professor of Medicine and Director of the Center for the Study of Latino Health and Culture at the School of Medicine, UCLA. David Hayes-Bautista was the first person of color to graduate from the medical sociology program at UCSF. Ruth E. Zambrana, PhD, Professor at the University of Maryland, College Park, Department of Women's Studies, Director of the Consortium on Race, Gender and Ethnicity, Interim Director of the U.S. Latino Studies Initiative at the University of Maryland, College Park, and Adjunct Professor of Family Medicine at University of Maryland Baltimore, School of Medicine, Department of Family Medicine Chapter 1: Latinx in the US: An Introduction to Demographic Trends and the Epidemiology of Health and Well-BeingAuthors: Rhodes and Martinez In this chapter, the editors will describe demographic changes in the US over time, outline what the population of Latinas/os will look like in the future, outline some of the major health issues facing Latinos/Latinas; describe the rationale for and significance of this book; outline the structure of book (i.e., 2 sections: (1) The health status of Latinas/os in the US, and (2) Communities, Systems, and Structures); and the subsequent chapters; identify cross chapter themes; and delineate next steps in terms of research to improve the health and well-being of Latinas/Latinos in the US. All subsequent chapters will adhere to the following structure: 1. Describe current state of epidemiology/knowledge with consideration to subgroups and heterogeneity of population as relevant (7-10 pages)2. Review of relevant conceptual/theoretical approaches (1-2 pages)3. Briefly identify successful research and interventions (2-3 pages)4. Identify research and intervention needs and priorities (3-5 pages) Section 1: The Health Status of Latinx in the US Chapter 2: Chronic DiseaseAuthors: Barbara Baquero, PhD, MPH (University of Iowa) and colleagues. Chapter 3: Sexual and Reproductive HealthAuthors: Scott D. Rhodes, PhD, MPH (Wake Forest School of Medicine) and colleagues. Chapter 4: Occupational Health Authors: Abel Valenzuela, PhD (UCLA) and colleagues. Chapter 5: Mental HealthAuthors: Hector M. Gónzalez, PhD (Michigan State University) and colleagues. Chapter 6: Im/Migrant HealthAuthors: Thomas Painter, PhD (Centers for Disease Control and Prevention) and colleagues. Chapter 7: LGBT HealthAuthors: Scott D. Rhodes, PhD, MPH (Wake Forest School of Medicine) and colleagues. Chapter 8: Aging and Older Latinas/osAuthors: Adriana Pérez, PhD, ANP (University of Pennsylvania School of Nursing) and colleagues. Chapter 9: Disabilities Among Latinas/osAuthors: Fabricio Balcazar, PhD, (Department of Disability and Human Development at University of Illinois at Chicago) and colleagues. Chapter 10: Substance UseAuthors: Flavio Marsiglia, PhD, MSW (School of Social Work & Southwest Interdisciplinary Research Center Arizona State University) and colleagues. Section 2: Communities, Systems, and Structures Chapter 11: ACA and Health Care UtilizationAuthors: Mark Hall, JD, and Lilli Mann, MPH (Wake Forest Schools of Medicine and Law) Chapter 12: Immigration Enforcement Policies and HealthAuthors: Heide Castañeda, PhD, MPH (University of South Florida) and colleagues. Chapter 13: The Built EnvironmentAuthors: Francisco Lara-Valencia, PhD (Arizona State University) and colleagues. Chapter 14: Expansions of AcculturationAuthors: Airin D. Martinez, PhD, (Arizona State University), Samantha Sabo, PhD, MPH, (University of Arizona), Rebecca Crocker, PhDc (University of Arizona) Alma Hernández, PhDc (University of New Mexico) Chapter 15: DiscriminationAuthors: Edna Viruell-Fuentes, PhD, MPH (University of Illinois
Urbana-Champaign Chapter 16: Representation, Politics, and LeadershipAuthors: Carlos Rodriguez-Diaz, PhD, MPH (University of Puerto Rico).

Contents:
Methods for determining the reduction potentials of flavin enzymes / Shelbi L. Christgen, Sophia M. Becker and Donald F. Becker
Anaerobic methods for the transient-state study of flavoproteins: The use of specialized glassware to define the concentration of dioxygen / Graham R. Moran
Performing anaerobic stopped-flow spectrophotometry inside of an anaerobic chamber / Hannah Valentino and Pablo Sobrado
Chemical quenching and identification of intermediates in flavoenzyme-catalyzed reactions / Kalani Karunaratne and Tatiana V. Mishanina
On the use of noncompetitive kinetic isotope effects to investigate flavoenzyme mechanism / Kevin Francis and Giovanni Gadda
Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms / Andreea I. Iorgu, Matthew J. Cliff, Jonathan P. Waltho, Nigel S. Scrutton and Sam Hay
Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships / Christopher J. Thibodeaux, Wei-chen Chang and Hung-wen Liu
Vibrational spectroscopy of flavoproteins / James N. Iuliano, Jarrod B. French and Peter J. Tonge
Measuring electronic structure properties of flavins and flavoproteins by electronic stark spectroscopy / Robert J. Stanley and Cornelius J. van Galen
EPR spectroscopy on flavin radicals in flavoproteins / Daniel Nohr, Stefan Weber and Erik Schleicher
Applications of molecular modeling to flavoproteins: Insights and challenges / Emil Sjulstok, Ilia A. Solov'yov and Peter L. Freddolino
Exploring the sequence, function, and evolutionary space of protein superfamilies using sequence similarity networks and phylogenetic reconstructions / Janine N. Copp, Dave W. Anderson, Eyal Akiva, Patricia C. Babbitt and Nobuhiko Tokuriki
Structural methods for probing the interaction of flavoenzymes with oxygen and its surrogates / Raspudin Saleem-Batcha and Robin Teufel
Reduction midpoint potentials of bifurcating electron transfer flavoproteins / A.-F. Miller, H.D. Duan, T.A. Varner and N. Mohamed Raseek
Investigations of two-component flavin-dependent monooxygenase systems / John M. Robbins and Holly R. Ellis
The styrene monooxygenase system / George T. Gassner
Flavin-N5-oxide intermediates in dibenzothiophene, uracil, and hexachlorobenzene catabolism / Sanjoy Adak and Tadhg P. Begley
Prenylated FMN: Biosynthesis, purification, and Fdc1 activation / Anna N. Khusnutdinova, Johnny Xiao, Po-Hsiang Wang, Khorcheska A. Batyrova, Robert Flick, Elizabeth A. Edwards and Alexander F. Yakunin
Heterologous production, reconstitution and EPR spectroscopic analysis of prFMN dependent enzymes / Stephen A. Marshall, Karl A.P. Payne, Karl Fisher, Deepankar Gahloth, Samuel S. Bailey, Arune Balaikaite, Annica Saaret, Irina Gostimskaya, Godwin Aleku, Huanming Huang, Stephen E.J. Rigby, David Procter and David Leys
Physical methods for studying flavoprotein photoreceptors / Estella F. Yee, Siddarth Chandrasekaran, Changfan Lin and Brian R. Crane.

Summary: This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Contents:
Preface
Part 1. Historical View
Drug discovery in the past and today.Part 2. Target Discovery
Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis
Part 3. Lead generation and Optimization
Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals
Part 4. Test systems for Efficacy and Safety
In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.

Summary: This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also℗ℓincludes discussion of℗ℓnew areas℗ℓsuch as℗ℓbiotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have℗ℓbeen the subject of discussion℗ℓin this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Contents:
Anticancer drug discovery approaches; challenges and development
An Evidence Based Approach to Traditional Herbal Remedies for the Management of Cancer
Marine-derived Anticancer Compounds
Anti-cancer Antibiotics
Anticancer terpenoids; Carbohydrates Against Cancer. .

Contents:
Chapter 1. The Need for Change: Embracing the Genome / William B. Whitman
Chapter 2. An Introduction to Phylogenetics and the Tree of Life / Tom A. Williams, Sarah E. Heaps
Chapter 3. The All-Species Living Tree Project / Pablo Yarza, Raul Munoz
Chapter 4. 16S rRNA Gene-Based Identification of Bacteria and Archaea using the EzTaxon Server / Mincheol Kim, Jongsik Chun
Chapter 5. Revolutionizing Prokaryotic Systematics Through Next-Generation Sequencing / Vartul Sangal, Leena Nieminen, Nicholas P. Tucker, Paul A. Hoskisson
Chapter 6. Whole-Genome Analyses: Average Nucleotide Identity / David R. Arahal
Chapter 7. Whole-Genome Sequencing for Rapid and Accurate Identification of Bacterial Transmission Pathways / Simon R. Harris, Chinyere K. Okoro
Chapter 8. Identification of Conserved Indels that are Useful for Classification and Evolutionary Studies / Radhey S. Gupta
Chapter 9. Reconciliation Approaches to Determining HGT, Duplications, and Losses in Gene Trees / Olga K. Kamneva, Naomi L. Ward
Chapter 10. Multi-Locus Sequence Typing and the Gene-by-Gene Approach to Bacterial Classification and Analysis of Population Variation / Alison J. Cody, Julia S. Bennett, Martin C.J. Maiden
Chapter 11. Multi-locus Sequence Analysis: Taking Prokaryotic Systematics to the Next Level / Xiaoying Rong, Ying Huang
Chapter 12. Bacterial Typing and Identification By Genomic Analysis of 16S-23S rRNA Intergenic Transcribed Spacer (ITS) Sequences / Volker Gürtler, Gangavarapu Subrahmanyam, Malathi Shekar, Biswajit Maiti, Indrani Karunasagar
Chapter 13. MALDI-TOF Mass Spectrometry Applied to Classification and Identification of Bacteria / Peter Schumann, Thomas Maier
Chapter 14. Continuing Importance of the “Phenotype” in the Genomic Era / Peter Kämpfer
Index.

Summary: This book offers a highly informative guide to forceps devices and delivery techniques. Extensive figures and animations offer readers vivid insights into the fetus station, pelvis, and inserted forceps. The book covers normal presentation and abnormal rotation, presentation and attitudes, and especially focuses on the assessment of fetal descent. It discusses the problem with conventional fetal station, and explains the revised one based on the trapezoidal plane. Instrumental delivery is chosen in cases of worrisome fetal status, protracted labor, or maternal fatigue. Forceps can provide a greater pulling power than vacuum extraction, and the fetus can be delivered in a short time, though this technique calls for experience and technical proficiency. The book argues that in order to ensure safe and reliable forceps delivery, assessment of the fetal station and the site of the largest fetal head circumference is critical. The book offers a new and indispensable reference guide for all obstetricians, not only for residents, but also for all experienced professionals involved in the training of beginners, and even for those using vacuum extraction who would like to assess the fetus more objective and practically.

Contents:
Front Cover
Title Page
Copyright
Dedication
Contents
Preface
Acknowledgments
Chapter 1. Preparing Your Mind
Chapter 2. "Gearing" Up
Chapter 3. Finding a Pediatrician
Chapter 4. Taking Care of You and Your Partner
Chapter 5. Finding a Child Care Provider
Chapter 6. In the Hospital
Chapter 7. What's Typical, What's Not
Chapter 8. Setting Yourself Up for Breastfeeding Success
Chapter 9. At Home in the First Few Weeks
Self-care Guides and Newborn Care Resources
Index
Back Cover

Contents:
v.1. Mammary carcinoma, basal and squamous cell carcinoma, etc.
v.2. Cardiac muscle
v.3. New discoveries in hematology

Contents:
History of abdominoplasty
Anatomy of the abdominal panniculus Pre-operatory evaluation of the abdomen and surgical planning
New umbilical region
Its creation during abdominoplasty
Abdominoplasty
Personal technique
Preservation of perforator vessels during abdominoplasty
Miniabdominoplasty
Personal technique
Abdominoplasty combined with liposuction
Upper abdominoplasty
Lower abdominoplasty
Full abdominoplasty
The use of surgical principles to Improve rhytidoplasty Procedure
Preservation of the future pedicle of the auricle to improve ear reconstruction
Abdominoplasty to improve body contouring
Abdominoplasty combined with lipo injection to improve body contouring
Abdominoplasty associated with superficial liposuction: selection of patients and indications
Medial tight lifting
Aesthetic plastic surgery of the axila
Plication of the medial infraumbilical wall to reduce the final surgical scar of abdominoplasty
Plication of the supraumbilical abdominal wall during abdominoplasty
Robotic procedure for plication of the musculo-aponeurotic abdominal wall
"H" shaped plication of the aponeurotic wall on abdominoplasty
Abdominoplasty combined with mastoplasty
Secondary abdominoplasty
Combination of liposuction with abdominoplasty for breast reconstruction
Complications during and after abdominoplasty.

Summary: This book gathers selected, extended and revised contributions to the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018), and the 3rd Conference on Imaging and Visualization, which took place on 26-29 March, 2018, in Lisbon, Portugal. The respective chapters highlight cutting-edge methods, e.g. new algorithms, image analysis techniques, and multibody modeling methods; and new findings obtained by applying them in biological and/or medical contexts. Original numerical studies, Monte Carlo simulations, FEM analyses and reaction-diffusion models are described in detail, together with intriguing new applications. The book offers a timely source of information for biologists, engineers, applied mathematicians and clinical researchers working on multidisciplinary projects, and is also intended to foster closer collaboration between these groups.

Contents:
Intro; Preface; Contents; About the Editors; The Impact of Patches on Blood Flow Disorders In Carotid Artery; 1 Introduction; 2 Methods; 2.1 Mathematical Analysis; 2.2 Summary; 2.3 Numerical Analysis; 3 Results; 4 Conclusions; References; Numerical Study of Carotid Bifurcation Angle Effect on Blood Flow Disorders; 1 Introduction; 2 Methods; 3 Results; 4 Conclusions; References; Evaluating the Effect of Tissue Anisotropy on Brain Tumor Growth Using a Mechanically Coupled Reaction-Diffusion Model; 1 Introduction; 2 Materials and Methods; 2.1 Mathematical Model; 2.2 Simulation Domain 2.2 Material Constitutive Modeling3 Results and Discussion; 4 Conclusions; References; New Techniques for Combined FEM-Multibody Anatomical Simulation; 1 Introduction; 2 Reduced Coordinate Modeling; 2.1 Reduced Dynamics; 2.2 Application to an FEM Tongue Model; 2.3 Application to an FEM Foot Model; 3 Attaching Points and Frames to Deformable Bodies; 3.1 Point Attachments; 3.2 Frame Attachments; 4 Skinning and Embedded Meshes; 4.1 Skinning for Modeling the Human Airway; 4.2 Mesh Embedding Applied to Modeling the Masseter; 5 Conclusion; References 2.3 Simulation Assumptions2.4 Analysis; 3 Results; 4 Discussion; 5 Conclusion; References; Prediction of Stress and Strain Patterns from Load Rearrangement in Human Osteoarthritic Femur Head: Finite Element Study with the Integration of Muscular Forces and Friction Contact; 1 Introduction; 2 Methods; 3 Results and Discussion; 4 Conclusions; References; Numerical Simulation of the Deployment Process of a New Stent Produced by Ultrasonic-Microcasting: The Role of the Balloon's Constitutive Modeling; 1 Introduction; 2 Description of the Methodology; 2.1 Geometry 2.6 Modeling Cell Deformation During Cancer Metastasis3 Discussion; 4 Conclusion; References; Estimation of 6 Degrees-of-Freedom Accelerations from Head Impact Telemetry System Outputs for Computational Modeling; 1 Introduction; 2 Methods; 3 Results; 4 Discussion; 5 Conclusion; References; Physiological Cybernetics: Methods and Applications; 1 Introduction: Physiological Cybernetics; 2 Homeostasis; 3 Modeling and Control; 4 Case Studies; 5 Conclusions; References; New Computational Solution to Compute the Uptake Index from 99mTc-MDP Bone Scintigraphy Images; 1 Introduction Computational Cell-Based Modeling and Visualization of Cancer Development and Progression1 Introduction; 1.1 Mathematical Modeling on Various Scales; 1.2 Mathematical Modeling from a View of Cancer Development and Progression; 1.3 Mathematical Modeling from a View of Identified Cancer Types; 1.4 Mathematical Modeling from a View of Model Types; 2 Mathematical Concepts; 2.1 Applications; 2.2 Modeling Tumor Initiation; 2.3 Modeling of T-cells Migration in Pancreatic Cancer; 2.4 Modeling Angiogenesis; 2.5 Modeling of Durotaxis-Driven Migration of Cancer Cells in Metastasis

Contents:

v. 1. Developmental considerations.--
v. 2. Deviations in development.

Summary: This book focuses on hot issues faced by clinicians in everyday clinical practice, and provides in-depth analyses of both met and unmet needs in the management of psychiatric disorders. It has been repeatedly shown that the needs of patients, relatives, the community at large and those of the governmental bodies only partially overlap. For instance, patients in their families are more concerned about quality of life, treatment, autonomy, and independent living; whereas governmental stakeholders are typically more concerned about relapse prevention and reduction of hospitalizations. As such, a volume bridging the gap between theoretical notions and practical understanding of patients untreated aspects of their psychiatric disorders is much needed. Instead of focusing on traditional descriptions of psychopathology and diagnostic criteria, the volume guides readers to core problems for each topic, taking into account new approaches in the classification of mental disorders as proposed by DSM-5. It elaborates on much-debated controversial problems such as the assessment and treatment of psychomotor agitation, and non-adherence to treatment that impacts on the psychiatric context. With its unique approach, this volume appeals to anyone with an interest in the field, including researchers, clinicians, and trainees.

Contents:
Foreword
Preface.-1.Unmet needs in modern psychiatric practice.-2.Unmet needs in patients with schizophrenia
3.The Unmet Needs for Major Depressive Disorder.-4.Unmet Needs in Psychiatry: Bipolar Depression.-5.Unmet needs in mixed-states.-6.Unmet needs in personality disorders.-7.Unmet needs in the assessment and treatment of psychomotor agitation.-8.Unmet needs in the management of suicide risk.-9.Unmet needs in education in psychiatry.-10.Unmet needs of resident's.-11.Unmet needs in youth mental health: transforming models of care to improve outcomes.-12.Classification systems of mental disorders
where did we go wrong?.-13.Stigma: an old unmet need in psychiatric practice.

Summary: The purpose of the book is to advance in the understanding of brain function by defining a general framework for representation based on category theory. The idea is to bring this mathematical formalism into the domain of neural representation of physical spaces, setting the basis for a theory of mental representation, able to relate empirical findings, uniting them into a sound theoretical corpus. The innovative approach presented in the book provides a horizon of interdisciplinary collaboration that aims to set up a common agenda that synthesizes mathematical formalization and empirical procedures in a systemic way. Category theory has been successfully applied to qualitative analysis, mainly in theoretical computer science to deal with programming language semantics. Nevertheless, the potential of category theoretic tools for quantitative analysis of networks has not been tackled so far. Statistical methods to investigate graph structure typically rely on network parameters. Category theory can be seen as an abstraction of graph theory. Thus, new categorical properties can be added into network analysis and graph theoretic constructs can be accordingly extended in more fundamental basis. By generalizing networks using category theory we can address questions and elaborate answers in a more fundamental way without waiving graph theoretic tools. The vital issue is to establish a new framework for quantitative analysis of networks using the theory of categories, in which computational neuroscientists and network theorists may tackle in more efficient ways the dynamics of brain cognitive networks. The intended audience of the book is researchers who wish to explore thevalidity of mathematical principles in the understanding of cognitive systems. All the actors in cognitive science: philosophers, engineers, neurobiologists, cognitive psychologists, computer scientists etc. are akin to discover along its pages new unforeseen connections through the development of concepts and formal theories described in the book. Practitioners of both pure and applied mathematics e.g., network theorists, will be delighted with the mapping of abstract mathematical concepts in the terra incognita of cognition.

Contents:
Research tools and paradigms
State of the Art: Mathematical approaches in brain science
The Categorical Imperative: Category theory in Cognitive and Brain Science
Elementary principles in cognitive systems modeling
The shift towards structure
A general framework for representation
Towards a Theory of Brain Structure and Function
A theory of hippocampus structure and function based on Category Theory
From Cells to Memories. A Categorical Approach
Epilogue.

Summary: The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.

Contents:
Intro
Preface
EVs: A Diverse Community
Functional Role and Clinical Implications of EVs
Contents
About the Editors
Part I: Subtypes, Biogenesis, and Secretion of Extracellular Vesicles
Chapter 1: Introduction to the Community of Extracellular Vesicles
Introduction
Subtypes of EVs
Molecular Composition of EVs
Isolation and Characterisation of EVs
Concluding Remarks
References
Chapter 2: Biogenesis of Extracellular Vesicles
Introduction: Extracellular Vesicles
Large Oncosomes
Apoptotic Bodies
Migrasomes
Ectosomes/Shedding Microvesicles ApoBDs in Cell Clearance
ApoBDs in Intercellular Communication
Intercellular Communication Through DNA as Cargos
Intercellular Communication Through RNA as Cargos
Intercellular Communication Through Proteins as Cargos
Intercellular Communication Through Pathogen-Derived Material
Concluding Remarks
References
Chapter 5: Exomeres: A New Member of Extracellular Vesicles Family
Introduction
Exomeres
Proteomic Cargo of Exomeres
Isolation of Exomeres
Concluding Remarks
References
Part II: Functional Role and Clinical Implications of Extracellular Vesicles Chapter 4: Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance
Introduction
Mechanisms of Apoptotic Cell Disassembly
Step 1: Plasma Membrane Blebbing
Step 2: Apoptotic Membrane Protrusion Formation
Pannexin 1
Plexin B2
Cytoskeleton
Vesicle Trafficking
Step 3: ApoBD Fragmentation
Maintenance of Plasma Membrane Integrity to Prevent Premature Lysis
Methods of ApoBD Isolation
Differential Centrifugation
Filtration
Fluorescence-Activated Cell Sorting (FACS)
Validation of ApoBDs
Functional Significance of ApoBD Formation Chapter 6: Pathogenesis Mediated by Bacterial Membrane Vesicles
Introduction
What are Bacterial Membrane Vesicles?
The Study of BMVs
Isolation and Purification
Characterisation & Analysis
BMV Biogenesis
Mechanisms of OMV Biogenesis
Mechanisms of MV Biogenesis
Cargo Packaging into BMVs
Physiological Roles of BMVs
Physiological Roles of OMVs Produced by Gram-Negative Bacteria
Biofilm Formation
Nutrient Acquisition
Competition and Predation
Bacterial Defence
Horizontal Gene Transfer
Physiological Roles of MVs Produced by Gram-Positive Bacteria Exosomes
ESCRT-Dependent Pathway of ILV Biogenesis
ESCRT-Independent Pathway of ILV Biogenesis
Role of Tetraspanins in Biogenesis of Exosomes
Secretion of Exosomes
Exomeres
Concluding Remarks
References
Chapter 3: The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles
Introduction
Phosphorylation
Glycosylation
Ubiquitination
SUMOylation
Oxidation
Citrullination
ISGylation
Myristoylation
Palmitoylation
Concluding Remarks
References

Summary: This book updates the reader about the latest bio-mechanical concepts underlying keratoconus diagnosis and the various treatment alternatives: from conventional alternatives with a real cost/benefit description, to some innovative alternatives that have come to the fore in recent years. It discusses the latest software and technology utilized in keratoconus diagnosis as well as the more innovative surgical techniques used to treat keratoconus. New Frontiers for the Treatment of Keratoconus represents an essential book for ophthalmologists and specialists in cornea and refractive surgery who are looking to position themselves at the forefront of the diagnosis and treatment of keratoconus.

Contents:
Introduction
New features in corneal biomechanics
Corneal Topography, corneal tomography and epithelial maps
Histopathological findings in keratoconus
The last developments in keratoconus diagnosis
Intracorneal rings to treat keratoconus
Phakic intraocular lens to treat keratoconus
Stromal regeneration
Excimer laser to treat keratoconus
Corneal remodeling to treat keratoconus.

Summary: Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans. This book brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic field.

Contents:
Preface
Robin Dunbar: What's so social about the social brain?
Steve Rogers: The neurobiology of a transformation from asocial to social life during swarm formation in desert locusts
Jakob Bro-Jorgensen: Social neuroscience and the study of animal communication.- Jay J. van Bavel et al.: The group mind: the pervasive influence of social identity on cognition
Sarah Blaffer Hrdy: Development and social selection in the emergence of "emotionally modern" humans
Mark van Vugt: On faces, gazes, votes, and followers: evolutionary psychological and social neuroscience approaches to leadership
Craig Ferris: Using awake animal imaging to understand neural circuits of emotion: studies ranging from maternal care to aggression
Jean Decety: The neuro-evolution of empathy and caring for others: why it matters for morality.- Beatrice de Gelder and Ruud Hortensius: The many faces of the emotional body
Kiley J. Hamlin: The origins of human morality: complex socio-moral evaluations by preverbal infants
Ilanit Gordon: Can oxytocin improve core brain and behavioral features of Autism Spectrum Disorders in children?
Jack van Honk et al.: Testosterone and dominance in humans: behavioral and brain mechanisms
Subject index.

Summary: Using accessible farming practices to meet the growing demands on agriculture is likely to result in more intense competition for natural resources, increased greenhouse gas emissions, and further deforestation and land degradation, which will in turn produce additional stress in the soil-water-plant-animal continuum. Stress refers to any unfavorable force or condition that inhibits customary functioning in plants. Concurrent manifestations of different stresses (biotic and abiotic) are very frequent in the environment of plants, which consequently reduces yield. Better understanding stress not only changes our perspective on the current environment, but can also bring a wealth of benefits, like improving sustainable agriculture and human beings living standards. Innovative systems are called for that protect and enhance the natural resource base, while increasing productivity via 'holistic approaches, such as agroecology, agro-forestry, climate-smart agriculture and conservation agriculture, which also incorporate indigenous and traditional knowledge. The book 'New Frontiers in Stress Management for Durable Agriculture' details the current state of knowledge and highlights scientific advances concerning novel aspects of plant biology research on stress, biotic and abiotic stress responses, as well as emergent amelioration and reclamation technologies to restore normal functioning in agroecology.

Contents:
Intro
Preface
Acknowledgement
Contents
Editors and Contributors
About the Editors
Contributors
Part I: Abiotic Stress Response in Plants and Approaches Towards Mitigation
1: Physiological Responses and Resilience of Plants to Climate Change
1.1 Introduction
1.2 Climate Change and Limiting Factors for Crop Development
1.3 Physiological Responses of Plants to Climate Change
1.4 Resilience of Plant to Climate Change
1.4.1 Avoidance Mechanism
1.4.2 Physiological Mechanisms
1.4.2.1 Phytohormonal Modulation
1.4.2.2 ROS Scavenging Systems 1.4.2.3 Signal Sensing, Transduction and Stress Response
1.4.2.4 Heat-Shock Proteins (HSPs)
1.5 Approaches Towards Improved Understanding of Resilience
1.6 Intervention for Expanding Resilience
1.7 Conclusion
References
2: Allelopathy: Implications in Natural and Managed Ecosystems
2.1 Introduction
2.2 Allelopathy: Basics of the Discipline
2.3 Mechanism of Allelopathy
2.4 Role of Allelopathy in Natural Ecosystem
2.5 Role of Allelopathy in Managed Ecosystem
2.6 Prospective and Challenges in Allelopathic Research
2.7 Conclusions
References 3: Effect of Drought Stress on Crop Production
3.1 Introduction
3.2 Morphological Effect
3.2.1 Growth
3.2.2 Yield
3.3 Physiological Effects
3.3.1 Association Between Water Availability and Nutrient Requirement
3.3.2 Effect on Photosynthesis
3.3.3 Assimilate Partitioning
3.4 Drought Stress Causing Oxidative Damage
3.5 Conclusion and Future Prospects
References
4: Impact of Salinity Stress in Crop Plants and Mitigation Strategies
4.1 Introduction
4.2 Effect of Salinity on Crop Plants
4.2.1 Effect on Seed Germination and Growth 4.2.2 Effects on Photosynthesis
4.2.3 Effect on Water Relations
4.2.4 Effect on Lipids and Proteins
4.2.5 Effect on Antioxidative Machinery
4.2.6 Effect on Yield of Crop Plants
4.3 Mitigation Strategies for Salinity
4.3.1 Salinity Mitigation by Employing Proper Management Practices
4.3.2 Salinity Mitigation Using Bacteria and Mycorrhizal Fungi
4.3.3 Mitigation of Salinity Stress by Exploiting Plant Salinity Tolerance and Transgenics
References
5: Sustainable Production of Rice Under Sodicity Stress Condition
5.1 Introduction 5.2 Sodicity Trend Around the Globe and India
5.3 Sodicity as a Property
5.4 Sodicity as a Constrain in Rice Production
5.5 Strategies for Rice Production Under Sodicity
5.5.1 Vegetative Bioremediation
5.5.2 Incorporating Inorganic Fertilizers by Organic Amendments
5.5.3 Reutilisation of Drainage Water
5.5.3.1 Cyclic Reuse
5.5.3.2 Reuse After Blending
5.5.3.3 Sequential Reuse
5.5.4 Molecular Approach Towards Sustainable Rice Production Under Sodicity
5.6 Future Prospects Towards Sustainable Rice Production
References

Summary: This book illustrates why a holistic approach is important in Pediatric Palliative Care (PPC). Readers will learn this approach has a horizonta axis, featuring the patients mental and physical needs, as well as their environments. It has also a "vertical axis" the evolutive changes of the patients throughout their development and their illness, their aspirations and fears. An evolutive (or dynamic) approach is mandatory. Each child/parent has a different experience of illness and a different path to recovery that is influenced by their age, gender, culture, but also by the state of their grief. To take care of them, we need to know the state of the subjects we are dealing with throughout their evolution in age (children) and in sorrow (both children and parents). Jungs and Piaget schemes will be of support. This book also helps caregivers to know what ethics is. It teaches a new insight on the word ethics not a series of principles or norms, but an approach based on humanistic virtues. Two criteria will be proposed to this aim: an ethics based on the refusal of inauthentic behaviors (or those behaviors that are copies of animals or machines) and a new criterion that even children have some ethical duties (not based on rules, but on naturally acceptance that their sight is modulated by the presence of their parents and friends). This ethical approach is explained to caregivers in a practical mode, ready for clinical exigencies. This book is also unique because it demonstrates that PPC also involves the true care of caregivers. It will explain how to approach, measure and overcome caregivers burn-out. Special attention is devoted to the approach to babies and childrens pharmacological and non-pharmacological analgesia and sedation. Pain assessment methods will be illustrated, as well as the development of a PPC web on the territory. This text includes perinatal and neonatal PPC. The book will be of valuable support to all those intensivists, pediatricians, nurses, psychologists, physiotherapists and healthcare professionals working in PPC units.

Contents:
Part I: A physiological basis of neurovascular coupling. Neurogenic control of parenchymal arterioles in the cerebral cortex / H. Hotta
Involvement of astrocytes in neurovascular communication / M. Nuriya, H. Hirase
Vascular potassium channels in NVC / K. Yamada / Part II: Methodology for measurements of brain circulation. Bridging macroscopic and microscopic methods for the measurements of cerebral blood flow: Toward finding the determinants in maintaining the CBF homeostasis / I. Kanno, K. Masamoto
New horizons in neurometabolic and neurovascular coupling from calibrated fMRI / C.Y. Shu, B.G. Sanganahalli, D. Coman, P. Herman, F. Hyder
Submillimeter-resolution fMRI: Toward understanding local neural processing / M. Fukuda, A.J. Poplawsky, S.-G. Kim
Hemodynamic signals in fNIRS / Y. Hoshi / Part III: Plastic changes in neurovascular coupling. Mechanisms of cellular plasticity in cerebral perivascular region / N. Egawa, J. Lok, K. Arai
Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina / T. Kurihara
Neurovascular coupling and energy metabolism in the developing brain / M. Kozberg, E. Hillman
Exercise and cerebrovascular plasticity / T. Nishijima, I. Torres-Aleman, H. Soya
Neurovascular coupling: what next? / K. Masamoto, H. Hirase, K. Yamada, I. Kanno.

Summary: This book provides a review of the most recent data on osteoporosis and bone health, presenting a vision of diagnosis and management for the year 2021 and beyond. It covers all pertinent aspects of bone health including diagnosis, fracture prevention, optimized practice, impaired orthostasis, and falls. The book examines recent developments in therapeutics, including goal-directed therapy, individualizing therapy, sequential and combined therapies, pharmaceuticals, and anabolic vs. antiresorptive therapy. In addition, it provides an in-depth overview of osteoporosis and bone health in complex patients, covering Duchene dystrophy, renal failure, periodontal diseases, and steroid-induced osteoporosis as well as considerations for pediatric populations and men. New Horizons in Osteoporosis Management is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses in rheumatology, endocrinology, radiology, pediatrics, primary care, and internal medicine. .

Contents:
Part I. Bone Health: Towards Better Bones
1. Bone Health and Osteoporosis
2. Recognizing People at Highest Risk of Fracture
3. T-score as an Indicator of Fracture Risk
Part II. Osteoporosis Diagnosis: Clinicians Guide
4. Current Imaging Techniques
5. The Challenges of Diagnosing Osteoporosis
6. The Role of the Radiographer in DXA Scan Service
7. Pitfalls in DXA Scanning
Part III. Fracture Prevention
8. Osteoporosis Update for Primary Care Physicians
9. Fracture Liaison Service
10. Imminent Fracture Risk
Part IV. Bone Health: Towards Optimized Practice
11. Guidelines for Management of Osteoporosis
12. The Role of Pharmacist in Osteoporosis Treatment
13. A Treatment Gap in Osteoporosis Management
14. Denosumab Vs Bisphosphonates
15. Romosozumab: Rebuilding the Bone Strength
16. Recent Trends in Osteoporosis Management
17. Optimizing Sequential and Combined Osteoporosis Therapy
Part V. Bone Health: Osteoporosis Treatment
18. Goal Directed Therapy
19. Long Term Osteoporosis Management
20. Complications of Osteoporosis Therapy
Part VI. Bone Health in Complex Patients
21. Pediatric Osteoporosis
22. Osteoporosis in Duchenne dystrophy
23. Osteoporosis in Renal Failure
24. Steroid Induced Osteoporosis
25. Osteoporosis in Men
26. Periodontal Diseases
27. Hormone Antagonist Therapy
Part VII. Bone Health, Falls, and Impaired Orthostasis
28. Disequilibrium
29. Dysautonomia
30. Sarcopenia
31. Advances in the Assessment and Management of Falls.

Contents:
Epidemiology of intracerebral haemorrhage / Poon, M.T.C., Bell, S.M., Al-Shahi Salman, R.
Emergency imaging of intracerebral haemorrhage / Alobeidi, F., Aviv, R.
Evidence-based critical care of intracerebral hemorrhage : an overview / Küppers-Tiedt, L., Steiner, T.
New insights into blood pressure control for intracerebral haemorrhage / Manning, L., Robinson, T.G.
Emergency reversal strategies for anticoagulation and platelet disorders / Levi, M.
Reperfusion-related intracerebral hemorrhage / Hayakawa, M.
Cerebral microbleeds : detection, associations, and clinical implications / Yakushiji, Y.
New insights into nonvitamin K antagonist oral anticoagulants' reversal of intracerebral hemorrhage / Yasaka, M.
Ultra-early hemostatic therapy for intracerebral hemorrhage : future directions / Wartenberg, K.E.
Ventriculostomy and lytic therapy for intracerebral hemorrhage / Ziai, W.C., Nyquist, P., Hanley, D.F.
Surgical craniotomy for intracerebral hemorrhage / Mendelow, A.D.
New insights in minimally invasive surgery for intracerebral hemorrhage / Wang, W.-M., Jiang, C., Bai, H.-M.
Surgical strategies for acutely ruptured arteriovenous malformations / Martinez, J.L., Macdonald, R.L.
Prognosis and outcome of intracerebral haemorrhage / Moulin, S., Cordonnier, C.

Summary: "A tenth-anniversary edition of the iconic bestseller '"one of the most influential books of the 20 years," according to the Chronicle of Higher Education' with a new preface by the author. Seldom does a book have the impact of Michelle Alexander's The New Jim Crow. Since it was first published in 2010, it has been cited in judicial decisions and has been adopted in campus-wide and community-wide reads; it helped inspire the creation of the Marshall Project and the new $100 million Art for Justice Fund; it has been the winner of numerous prizes, including the prestigious NAACP Image Award; and it has spent nearly 250 weeks on the New York Times bestseller list. Most important of all, it has spawned a whole generation of criminal justice reform activists and organizations motivated by Michelle Alexander's unforgettable argument that "we have not ended racial caste in America; we have merely redesigned it." As the Birmingham News proclaimed, it is "undoubtedly the most important book published in this century about the U.S." Now, ten years after it was first published, The New Press is proud to issue a tenth-anniversary edition with a new preface by Michelle Alexander that discusses the impact the book has had and the state of the criminal justice reform movement today."--Provided by publisher.

Contents:
Preface to the Tenth Anniversary Edition
Foreword / Cornel West
The rebirth of caste
The lockdown
The color of justice
The cruel hand
The new Jim Crow
The fire this time.

Summary: "Microbiology has undergone radical changes over the past few decades and ushered in an exciting new era in science. Microbes, specifically bacteria, are incredibly diverse: some are associated with disease and many others are essential for health. Bacteria are highly complex life forms able to communicate with each other and form mutually beneficial relationships with organisms they colonize. In plants, humans, and other animals, communities of microbes form biofilms and microbiota that use incredibly sophisticated strategies to influence their environment. The study of bacterial immune systems has led to a revolution: the development of the CRISPR/Cas9 system, a precise tool for editing DNA whose usefulness we are just beginning to imagine. Bacteria in both health and disease are at the forefront of global challenges we face today. They evolve to resist the antibiotics used against them, but they can also be used to modify mosquitoes that serve as carriers of diseases like malaria. As we learn about the complex and vitally important intestinal microbiome, it unlocks secrets to good health and potential treatments for problems such as obesity"--Provided by publisher.

Contents:
1. Bacteria: many friends, few enemies
2. Bacteria: highly organized unicellular organisms
3. The RNA revolution
4. From the CRISPR defense system to the CRISPR/Cas9 method for modifying genomes
5. Antibiotic resistance
6. Biofilms: when bacteria gather together
7. How bacteria communicate: chemical language and quorum sensing
8. When bacteria kill each other
9. Human-animal symbioses: the microbiotas
10. Bacterium-plant symbioses: microbiotas of plants
11. Endosymbiotic relationships
12. Pathogenic bacteria, major scourges, and new diseases
13. The multiple strategies of pathogenic bacteria
14. Pathogenic bacteria in insects
15. Plants and their pathogenic bacteria
16. New visions in infecction defense
17. Bacteria as tools for research
18. Bacteria: old and new health tools
19. Bacteria as environmental tools
Conclusion
Appendix: Major figues in microbiology.

Summary: Neurotology is a branch of medicine that focuses on diagnosing and treating neurological conditions of the inner ear and related structures. There have been many recent advances in neurotology that have been published in general medicine, otolaryngology and neurology journals. This comprehensive book will aggregate this information to provide a more complete picture of the state of the field and will include the authors' own clinical experience. There is a recent marked increase in interest in neurotology, manifested by the clinical experiences and research-publication work of otolaryngologists, neurologists, neuro-ophtalmologists, audiologists and physiotherapists. As a result, this will be a completely state-of-the-art work that includes all up-to-date neurophysiological data related to the vestibular system. It has been estimated that 10% of patients that present at an emergency clinic have vestibular disorders, including vertigo, and these disorders are frequently a cause of falls in elderly patients. On the other hand, many physicians treat their patients with vertigo with vestibular blockers, which treat the symptoms but do not cure the disorders. We feel that it is important to supply a source of information on the vestibular system and balance disorders, and this title will do that in a comprehensive manner.

Contents:
Introduction
1. Anatomy and Clinical Physiology of the Organs of Equilibrium
2. The Role of the Clinical History in Neurotology
3. An Introduction to Vestibular Disorders
4. The Bedside Tests: Practical Key Strategies to the Diagnosis of Vestibular and Oculomotor Disorders
5. Clinical Evaluation of the Vestibular System: The Vestibular Lab Tests
6. The Head Impulse Tests
7. The Role of Audiology in Clinical Neurotology
8. The Vestibular Syndromes
9. Menière's Disease
10. Vestibular Migraine
11. Benign Paroxysmal Positional Vertigo
12. Bilateral Vestibulopathy
13. Ataxia
14. Functional Vestibular Disorders
15. Glucose, Insulin and Inner Ear Pathology
16. Surgical Treatment of Vestibular Disorders.

Summary: Exercise cannot be underestimated for its role in slowing Parkinson's down. This book introduces the seven key concepts to help you get the most out of your exercise program, as well as easy strategies and hints to keep you motivated. Based on cutting edge research and tested extensively by Australian physiotherapists, this exercise program has been designed to bring out your inner warrior - your PD Warrior! The PD Warrior philosophy is that exercise, education, community, and a life-long commitment to fighting the symptoms of Parkinson's can help you develop a greater state of physical, mental, and social wellbeing.

Summary: "This book provides innovative practical suggestions regarding the production and management of medical records that are designed to address the inconsistencies and errors that have been highlighted especially in relation to national eHealth programs. Challenges and lessons that have emerged from the use of clinical information and the design of medical records are discussed, and principles underpinning the implementation of health IT are critically examined. New trends in the use of clinical data are explored in depth, with analysis of issues relating to integration and sharing of patient information, data visualization, big data analytics, and the requirements of modern electronic health records. The spirit pervading the book is one of co-production, in which the needs of practitioners are taken into account from the outset. Readers will learn the basic concepts of how clinical information emanating from the doctor-patient relationship can be effectively integrated with genetic and environmental data and analyzed by complex algorithms with the goal of improving medical decision making and patient care. The book, written by European experts and researchers, will be of interest to all stakeholders in the field, including doctors, technicians, and policy makers."--Back cover.

Summary: The New Public Health has established itself as a solid textbook throughout the world. Translated into seven languages, this work distinguishes itself from other public health textbooks, which are either highly locally oriented or, if international, lack the specificity of local issues relevant to students' understanding of applied public health in their own setting. Fully revised, The New Public Health, Fourth Edition provides a unified approach to public health appropriate for graduate students and advance undergraduate students especially for courses in MPH, community health, preventive medicine, community health education programs, community health nursing programs. It is also a valuable resource for health professionals requiring an overview of public health.

Summary: The book provides a unified approach to public health appropriate for all masters' level students and practitioners-specifically for courses in MPH programs, community health and preventive medicine programs, community health education programs, community health nursing programs.

Summary: This exciting, first-of-its-kind title describes the blossoming new science of medicine and managementthe concepts, methodologies, techniques, and tools that create value for patients, populations, caregivers, staff, and healthcare organizations. Developed out of the innovative and powerful physician executive MBA program at the Heller School of Social Policy and Management at Brandeis University, The New Science of Medicine & Management describes what physician leaders need to know and do to fix problems that can erode value in complex healthcare environments in which they practice medicine. The book is motivated by a singular propositionEvery Physician a Leader; Every Leader a Collaborative Team Player and a new definition of high-value health care. Composed of the best 18 of approximately 200 outstanding physician-led business school projects, the book is based on the collective efforts and experiences of 33 authors and coauthors, 28 of whom are physicians and 19 of whom have an MD and an MBA degree. The work is grounded in three important assertions: First, the clinical side of complex professional medical organizations such as hospitals has traditionally been led by highly skilled, highly experienced medical practitioners trained in the underlying biomedical disciplines and applied medical sciences. Second, there is research evidence that managers with clinical backgrounds can run better healthcare organizations, and a growing number of physician-led multispecialty groups are outperforming organizations run by lay managers. Third, physicians and other caregivers should have some training in the new science of medicine and management; moreover, and very importantly, the transition from clinician to clinical manager and leader is challenging and requires training in the new science of medicine and management. State of the art, developed by expert physician leaders in the field, and replete with a wide range of management insights and lessons, this book asks important questions and offers an exciting and comprehensive resource for all physicians, health administrators, and clinicians interested in not only the science of medicine and management and in developing physician-led teams but, crucially, in ensuring value in healthcare by improving patient outcomes, safety, affordability, and employee well-being.

Contents:
Intro
Foreword I
Foreword II
Preface
Part I
Part II
Part III
Part IV
Summary
Acknowledgments
Contents
List of Contributors
1: Introduction to the New Science of Medicine
Difficulty Involving Physicians in Health Care Performance Improvements
Quality as Ambiguous Versus the Value Revolution in Health Care
The Importance of Training Physicians in Management
The Science of Medicine and Management
The Clinical Side of Medical Organizations Are Led by Medical Practitioners Trained in the Bio-Medical Sciences Impact of Physician Leadership on Health Care Performance
The Difficult Transition from Clinical Staff Member to Clinical Manager
The Early Frontiers of Medicine and Management
Organizational Learning and the Case of Minimally Invasive Cardiac Surgery
Lesson
Explaining Variations in Risk-Standardized Mortality
Lesson
In-Hospital Cardiac Arrest
Lesson
Adoption of LEAN Management Is Not Implementation
Lesson
Managing for Medical Results at Intermountain Healthcare: Putting Medicine and Management Science to Work
A Few More Lessons about Medicine and Management The Way Forward
References
Part I: The Well-Managed Health Care Organization: Building Implementation into Strategic Thinking
2: Shouldice Hospital from Interviews and Observations: The Well Managed Organization
Introduction: The Well-Managed Health Care Organization
Literature Review
The First Stream: The Evolution of Hernia Surgery & the Search for an Optimal Hernia Repair
The Second Stream: Comparing Shouldice with Other Techniques
The Third Stream: Focused Factories and Well-Managed Organizations
Research Methodology The Current Hernia Repair Landscape: How Attractive Is this Service Line?
Shouldice Hospital: Analysis from Interviews and Observations
History: The Early Years of Shouldice
The Care Program: A Vision that Reconstructed the Boundaries for Hernia Surgery
Anesthesia and Conscious Sedation
Post-Operative Care: Immediate and Continuous Ambulation
Hyper-Focused Clinic and a Very High Volume of Cases
The Front Stage and the Key Clinical Activities
An Admission in Two Visits: Pre-Admission and Investigation
Day One: Admission and Investigation Prior to Surgery Day Two: Surgery and Therapy
Days Three and Four: Post-Surgery Recovery, Follow-Up, and Discharge
Patient Echoes and Frontstage Voices: The Patient Value Proposition
The Back Stage at Shouldice
Targeted Patient Segments
Shouldice Service Concept
Operating Strategy: Focused on Productive Efficiency and Quality
The Method and the Operating Rooms: Focused on Quality and Efficiency
A System and Culture of Patient-Centered Accountability
Well-Designed Service Delivery System
Organization Structure and People Management
People and Job Design

Contents:
Achilles tendon procedures
Lateral ankle ligament procedures
Arthroscopy of the ankle joint
Arthroscopy of the subtalar joint
Metatarsophalangeal joint procedures
Procedures for hindfoot axis deviations
Tendon transfer for the planovalgus foot
Forefoot surgery
Ankle arthroplasty
Aftercare protocols.

Summary: This book provides an up-to-date review of current management techniques for Non-Small Cell Lung Cancer. It addresses all of the latest issues that have been raised by the discovery of oncogenic drivers and the improvement of diagnosis and therapeutic methods, including new radiotherapy techniques and anticancer strategies like immunotherapy. New strategies for patients with molecular alterations and the management of particular types of cases are also highlighted. Written by recognized experts in their field, the book represents a unique and valuable resource in the field of lung cancer, both for those currently in training and for those already in clinical or research practice.

Contents:
Preface
Foreword
Screening
New Diagnostic Approaches
PET and Staging Minimally Invasive (EBUS)
Innovative Approaches in Early NSCLC
Minimally Invasive Surgery for Early NSCLC
Stereotaxic Radiotherapy in Localized Cancer
How to Personalize Perioperative Chemotherapy in Early Cancer?
New Approaches in Locally Advanced NSCLC
Advances in Radiotherapy for Locally Advanced NSCLC
Advances in Systemic Treatment for Locally Advanced NSCLC
Surgery of Advanced Tumors
New Approaches in Stage IV NSCLC
How to Personalize Chemotherapy in Stage IV NSCLC?
Supportive Care
Molecular Subgroups
Strategies in EGFR Mutated NSCLC Patients
Strategies in ALK Rearranged NSCLC patients
Strategies in KRAS mutated NSCLC Patients
Strategies in Patients with Other Molecular Alterations
New Approaches in Immunotherapy
Management of Particular Cases
Oligometastasis
Bone Metastasis
Brain Metastasis.

Summary: This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research. This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information. Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.

Contents:
Pathology of Melanoma and Skin Carcinomas
Molecular Landscape Profile of Melanoma
Molecular Landscape of Skin Carcinomas
Immunological Features of Melanoma
Dabrafenib and Trametinib
Vemurafenib and Cobimetinib
Encorafenib and Binimetinib
Vismodegib
Sonidegib
Ipilimumab
Nivolumab
Pembrolizumab
Talimogene Leharparepvec
Perspectives of Immunotherapy in Advanced Melanoma Combinations and Sequencing
Avelumab
Cemiplimab
Perspectives of Immunotherapy in Non-Melanoma Skin Cancers
Mechanisms of Resistance to Targeted Therapies in Skin Cancer
Mechanisms of Resistance to Immunotherapy
Neoadjuvant and Adjuvant Therapy in Melanoma
Adoptive Cell Therapy
Immunotherapy in Immunosuppressed Patients
New Therapies in Advanced Cutaneous Malignancies: Conclusions.

Summary: This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells capacity to regenerate appears "repressed" in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.

Contents:
Intro
Introduction
Contents
Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction
1 Introduction
2 Effects of Age on Auditory Function
3 Effects of Calorie Restriction on Aging
3.1 Types of Calorie Restriction Regimens
3.2 Effects of Calorie Restriction on Hearing Loss in Laboratory Animals
4 Mechanisms Underlying the Beneficial Effects of CR on AHL
4.1 Oxidative Stress
4.2 Apoptosis
4.3 mtDNA Mutations
5 Conclusion
References
Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science
1 Introduction 1 Introduction
1.1 Global Estimates and Impact of Hearing Impairment
1.2 Categories of Hearing Loss
1.3 Native HCs Regeneration Capacity in Mammals and Non-mammals
2 Approaches to Regenerate HCs and SGNs
2.1 Gene Therapy
Cochlear Gene Therapy Vehicles
2.2 Key Signaling Pathway Genes for HC Regeneration
2.3 Atoh1-Based Gene Therapy
2.4 Inactivation of Cell Cycle Inhibitors Based Gene Therapy
2.5 Gene Therapy for SGN Regeneration
3 Stem Cell Therapy
4 Conclusion
References 2 Cochlear Pathology
2.1 Oxidative Stress
2.2 Cochlear Blood Flow Changes
2.3 Apoptotic Cell Death
2.4 Mechanical Damage and Stereocilia Injury
3 Noise-Induced Deafferentation
3.1 Consequences of Synaptopathy
4 Auditory Threshold Shift as a Measure of Noise-Induced Hearing Loss
4.1 Extended High-Frequency Audiometry
5 Effects of Noise on Suprathreshold Measures of Hearing
5.1 Speech-in-Noise Testing
6 Pharmaceutical Otoprotection from Noise-Induced Hearing Loss
6.1 Antioxidants
6.2 Steroid Therapy
6.3 S-Ketamine and Glutamate Excitotoxicity 6.4 Cell Death and Stress Inhibitors
7 Summary
References
Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss
1 Significance and Background
2 Cisplatin Ototoxicity
2.1 Entry of Cisplatin into the Cochlea
2.2 Mechanisms Underlying Cisplatin Ototoxicity
Increased Oxidative Stress
Promoting Cellular Apoptosis
Covalent Modification of DNA
2.3 Pharmacogenomics of Cisplatin Ototoxicity
2.4 Approaches to Treating Cisplatin Ototoxicity
Relieving Oxidative Stress
Targeting Cochlear Inflammation Drugs Targeting G Protein-Coupled Receptors for Treating Cisplatin Ototoxicity
2.5 Ongoing Clinical Trials for Cisplatin Ototoxicity
3 Cyclodextrin-Induced Hearing Loss
4 Aminoglycosides
4.1 Overview
4.2 Studies Showing Hearing Loss
4.3 Uptake of Aminoglycosides into the Cochlea
4.4 Aminoglycoside Genetic Susceptibility
4.5 Preventative Strategies for Ototoxicity
Antioxidants
Inhibition of Apoptosis
Mechanoelectrical Transducer Channel Blockers
5 Summary
References
Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear

Summary: "An important item on the Workplan of FED (the Faculty of Eating Disorders Section of the Royal College of Psychiatrists) is the provision of high-quality training in the speciality. The New to Eating Disorders project has been based on two pioneering Scottish projects which had similar aims in different specialities: New to Forensic and New to CAMHS"-- Provided by publisher.

Summary: New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.

Summary: "New Understanding of Twin Relationships takes a phenomenological approach to exploring how twin attachment and estrangement are critical to understanding the push and pull of closely entwined personal relationships. Based on the research expertise of each of the authors (all identical twins in their own right), and vignettes from twins across the globe, this book describes the inner workings of the twin-world, showing how the twin-world creates experiences that are often more intense and intricately textured than those in the singleton-world. Chapters debunk myths surrounding twinship and analyze the developmental stages of the twin relationship as well as the effect of being a twin on one's mental health. The editors articulate how attachment, separation anxiety, loneliness, estrangement and the subjective experience of the twin and non-twin "other" impact behavior, thinking, and feeling. Through its careful study of the many psychological challenges that twins face throughout their lifetime, this text will help psychologists, scholars, and clinicians attain a deeper understanding of all interpersonal relationships"-- Provided by publisher

Contents:
Introduction / Barbara Klein, Stephan A. Hart, and Jacqueline M. Martinez
Myth, fantasy, and reality : the challenges twins face sharing their early lives and growing apart / Barbara Klein
The study of twin experience as twins : a phenomenological approach / Jacqueline M. Martinez
Communicative intricacies of the twin-world and twin-identities / Jacqueline M. Martinez
Parenting : the critical determinant of twin-attachment and mental health in twins / Barbara Klein
Developmental changes in twin relationships / Barbara Klein
"Alone without the mirror" I : humans, twins, and loneliness / Stephan A. Hart
"Alone without the mirror" II : twins, separation, and chronic twin-loneliness / Stephan A. Hart
"In the hall of mirrors" : twins living in the non-twin-world / Stephan A. Hart
Twin estrangement, significant others, and the relational matrices of the twin-world / Jacqueline M. Martinez
Can twins be alone in the mirror? : psychotherapy for twins / Barbara Klein
Conclusion / Barbara Klein, Stephan A. Hart, and Jacqueline M. Martinez.

Contents:
Chapter 1. Prenatal ultrasound
Chapter 2. General characteristics
Chapter 3. Head
Chapter 4. Eyes
Chapter 5. Ears
Chapter 6. Nose
Chapter 7. Jaw and mouth
Chapter 8. Neck
Chapter 9. Chest
Chapter 10. Abdomen
Chapter 11. Umbilicus
Chapter 12. Genitalia
Chapter 13. Extremities
Chapter 14. Back
Chapter 15. Skin
Chapter 16. Body fluids & substances
Appendixes
Index.

Contents:
Molecular bases for lung development, injury, and repair / Shu Wu
Perinatal events and their influence on lung development and injury / Suhas G. Kallapur and Alan H. Jobe
Vascular development and neonatal pulmonary circulation / Robin H. Steinhorn
The omics of the new BPD / Namasivayam Ambalavanan, Charitharth Vivek Lal and Vineet Bhandari
Role of microbiome in lung injury / Namasivayam Ambalavanan and Rose M. Viscardi
Definitions and diagnostic criteria of bronchopulmonary dysplasia : clinical and research implications / Eduardo Bancalari, Nelson Claure, Alan Jobe, Matthew Laughon
Patent ductus arteriosus and the lung : acute effects and long-term consequences / Martin Kluckow, Eduardo Bancalari, Ilene R.S. Sosenko, Nelson Claure
Ventilator-associated pneumonia / Thomas A. Hooven and Richard A. Polin
Long-term pulmonary outcome of preterm infants / Lex Doyle and Jeanie Cheong
Respiratory and cardiovascular support in the delivery room / Gary M. Weiner, Stuart B. Hooper, Peter G. Davis, Myra H. Wyckoff
Noninvasive ventilation of preterm infants : an alternative to mechanical ventilation / Brett J. Manley
Newer strategies for surfactant delivery / Peter Dargaville
Respiratory control and apnea in premature infants / Richard J. Martin, Vidhi Shah and Juliann Di Fiore
Oxygenation instability in the premature infant / Nelson Claure, Richard Martin, Juliann Di Fiore, Eduardo Bancalari
Optimal oxygenation in extremely preterm infants / Waldemar A. Carlo
Patient ventilator interaction / Nelson Claure, Eduardo Bancalari and Martin Keszler
Pulmonary-cardiovascular interaction / Shahab Noori
Ventilator strategies to reduce lung injury and duration of mechanical ventilation / Nelson Claure and Martin Keszler
Automation of respiratory support / Nelson Claure, Martin Keszler and Eduardo Bancalari
Pre and post natal steroids and pulmonary outcomes / Alan H. Jobe
Cell based therapy for neonatal lung diseases / Karen C Young, Bernard Thebaud, Won Soon
Management of the infant with severe bronchopulmonary dysplasia / Leif D. Nelin, Steven Abman and Howard Panitch.

Summary: The atlas focuses on the surgical steps of the latest hernia surgeries elucidated by labeled pictures. It aims to explain the technical aspects of hernia procedures. It includes images that are both graphic and intraoperative clinical photographs for better understanding. The book is written by international experts who have invented and pioneered the newer hernia procedures. Hernia surgery has evolved at a tremendous pace in the last decade. In the last decade, there has been a proliferation of more than 20 procedures in hernia repair, and they offer advantages compared to the older procedures in various clinical situations. Presently, the resources, including images of the newer procedures, are limited to the published journals. This book aims to fill this gap by providing technique based knowledge in an illustrated manner for learning newer hernia procedures. It is written in a succinct style. The book serves as a ready reference for practicing surgeons, minimal access surgeons and, resident surgeons, fellows.

Contents:
Extended Totally Extra Peritoneal (eTEP) Rives-Stoppa repair for lower midline hernia
Extended Totally Extra Peritoneal (eTEP) Rives-Stoppa for upper midline/ Subxiphoid hernia
Extended Totally Extra Peritoneal Transversus Abdominus Release (eTEP TAR) for midline hernia
Extended Totally Extra Peritoneal (eTEP) reapir for Lumbar hernia
Extended Totally Extra Peritoneal (eTEP) repair for Right iliac fossa incisional hernia
Extended Totally Extra Peritoneal (eTEP) repair for subcostal hernia
Extended Totally Extra Peritoneal (eTEP) repair for groin hernia
Mini or Less Open Sublay (MILOS) and e-MILOS repair for midline hernias
Transabdominal Retromuscular (TARM) approach to hernias
Subcutaneous Onlay Approach (SCOLA) repair
Pre aponeurotic Endoscopic Repair (REPA) and TESLA
Endoscopic assisted Line alba reconstruction (ELAR)
Transabdominal Retromuscular Umbilical Prosthetic repair (TARUP)
Transabdominal Preperitoneal approach to ventral hernia (TAPP)
Laparoscopic Intracorporeal Rectus Aponeuroplasty (LIRA)
Open Transversus Abdominus Release (TAR)
ACST and its modifications
Peritoneal flap for midline hernias
Peritoneal flap for lateral hernias
Modified peritoneal flap
STORM - parastomal hernia
Abdominoplasty
IPOM Plus - different suturing techniques
PPOM.

Summary: Learn and master a range of clinical techniques and achieve therapeutic goals with Newman and Carranza's Clinical Periodontology and Implantology, 14th Edition! Unmatched for its comprehensive approach, this resource provides detailed, up-to-date information on the etiology and pathogenesis of periodontal disease. Basic and advanced evidence-based information on the various treatment modalities employed in periodontics and implantology is presented in an easy-to-read format, with callout boxes throughout the text highlighting the clinical relevance of foundational basic science information. Full-color photos and radiographic images depict periodontal conditions and procedures, and the Atlas of Periodontal Pathology is one of the most comprehensive ever compiled in a periodontal textbook. Written by a team of leading experts led by Michael G. Newman, this text not only demonstrates how to perform periodontal procedures but explains the evidence supporting each treatment and provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook version included with print purchase also includes Periopixel 3D color illustrations, a periodontal classification calculator and interactive learning tool, review questions, case studies, videos, 3D animations, and more! This edition features new chapters on Precision Medicine, Pocket Reduction Therapy, Periodontal Referral, and Digital Implant Workflows, as well as an updated glossary of terms linked to the eBook. It also features first-of-its-kind content on the effects of COVID-19 on treatment from key opinion leaders in this area. Case studies reflect the new format of the Integrated National Board Dental Exam (INBDE).

Contents:
Fundamentals and Essential Evidence
Etiology and Pathogenesis
Gingival Pathology
Periodontal Pathology
Conditions Affecting the Periodontal Patient
Occlusion
Levels of Clinical Significance
Surgical Management of Periodontal Conditions
Fundamentals of Implantology
Prosthetic Considerations
Surgical Procedures
Digital Implant Workflow
Complications, Supportive Care and Results of Implant Treatment. Clinical Periodontology and Implantology in the Era of Precision Medicine
Evidence-Based Decision Making
Critical Thinking: Assessing Evidence
Anatomy, Structure, and Function of the Periodontium
Classification of Diseases and Conditions Affecting the Periodontium
Fundamentals in the Methods of Periodontal Disease Epidemiology
Atlas of Periodontal Diseases
Periodontal Disease Pathogenesis
Precision Dentistry: Genetics and Epigenetics of Periodontitis
Biofilm and Periodontal Microbiology
Host-Microbe Interactions and the Inflammatory Response
Resolution of Inflammation
Aging and the Periodontium
Defense Mechanisms of the Gingiva
Dental Biofilm-Induced Gingivitis and Its Management
Select Systemic and Local Diseases That Affect the Gingiva
Acute Gingival Infections and Management
Desquamative Gingivitis
Gingival Enlargement and Management
Periodontal Health and Disease in Children and Adolescents
Periodontitis
The Periodontal Pocket Formation and Patterns of Bone Loss
Risk Factors of Periodontal Disease (Smoking)
The Role of Dental Calculus and Other Local Predisposing Factors
Influence of Systemic Conditions on the Periodontium
Impact of Periodontal Infection on Systemic Health
Pathology and Management of Periodontal Problems Associated With Viral Infection, Including HIV, COVID, and Others
Periodontal Therapy in the Female Patient
Aging and Periodontal Health: A Long-Term Relationship
Acute Periodontal Infections and Management
Halitosis (Breath Malodor)
Periodontal Response to External Forces
Sleep-Related Breathing Disorders
Masticatory System Disorders That Influence the Periodontium
Role of Occlusion and TMD in Periodontal Disease Management
Levels of Clinical Significance
Electronic Dental Records and the Role of Health Information Technology in Dentistry
Periodontal Examination
Radiographic Aids in the Diagnosis of Periodontal Disease
Periodontal Risk Assessment
Determination of Prognosis
Periodontal Treatment Plan
Nonsurgical Phase of Periodontal Therapy
Clinical Practice Guideline for Treatment of Periodontitis
Restorative Interrelationships
Multidisciplinary Versus Interdisciplinary Approaches to Dental and Periodontal Problems
Periodontal Referral
Orthodontics in Periodontal Therapy
Endo-Perio Lesions
Plaque Biofilm Control for the Periodontal Patient
Sonic and Ultrasonic Instrumentation and Irrigation
Chemotherapy: Use of Systemic Antibiotics
Locally Delivered, Controlled-Release Antimicrobials
Host Modulation
Surgical Phase of Periodontal Therapy
Surgical Training and Technology
Sedation in Periodontics and Implant Surgery
Periodontal and Peri-Implant Surgical Anatomy
General Principles of Periodontal Surgery
Periodontal Surgical Therapy
Pocket Reduction Therapy-Resective Approach
Periodontal Regeneration
Lasers in Periodontal and Peri-Implant Therapy
Periodontal Plastic and Esthetic Surgery
Preparation of the Periodontium for Restorative Dentistry
Periodontal Treatment of Medically Complex Patients
Periodontal Microsurgery
Diagnosis and Management of Periodontal Abscesses
Supportive Periodontal Treatment
Results of Periodontal Treatment
Integrating Implants With Periodontal Therapy
Peri-Implant Anatomy, Biology, and Function
Clinical Evaluation of the Implant Patient
Diagnostic Imaging for the Implant Patient
Prosthetic Considerations: Partially Edentulous
Prosthetic Considerations: Fully Edentulous
Basic Implant Surgical Procedures
Advanced Implant Surgical Procedures: Horizontal and Vertical Augmentation
Advanced Implant Surgical Procedures: Maxillary Sinus Augmentation
Advanced Surgical Procedures: Simultaneous Implant Placement and Tissue Augmentation in the Esthetic Zone
Dental Implant Microsurgery: Immediate Placement
Piezoelectric Bone Surgery
Digitally Assisted Implant Placement Surgery
From Implant Placement to Provisional Restoration
Complications in Dental Implantology
Supportive Implant Treatment
Results of Implant Treatment.

Contents:
Part I. Getting to know yourself
Connecting your interests to careers
But I have no skills and other myths
Identifying your personal values
Part II. Getting to know the world of work
To postdoc or not to postdoc?
Career options for PhDs in science
Strategies for exploring careers and building experience
Networking effectively to uncover opportunities
Part III. Getting started on your job search
Crafting your individual development plan
Assembling your application materials and applying for jobs
Interviewing and negotiating tactics
Conclusion: Making a successful transition.

Contents:
Expression Screening of Integral Membrane Proteins by Fusion to Fluorescent Reporters
Detergents in Membrane Protein Purification and Crystallisation
NMR of Membrane Proteins: Beyond Crystals
Characterisation of Conformational and Ligand Binding Properties of Membrane Proteins Using Synchrotron Radiation Circular Dichroism (SRCD)
Membrane Protein Crystallization: Current Trends and Future Perspectives
Crystal Dehydration in Membrane Protein Crystallography
Nonlinear Optical Characterization of Membrane Protein Microcrystals and Nanocrystals
Exploiting Microbeams for Membrane Protein Structure Determination
Applications of the BLEND Software to Crystallographic Data from Membrane Proteins
Serial Millisecond Crystallography of Membrane Proteins
Serial Femtosecond Crystallography of Membrane Proteins
Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.

Contents:
Part I. Diangnosis, Patient Stratification and Biomarkers
A tale of two worlds: pharmaceutical investigators and clinicians define "diagnosis"
Biomarkers in clinical trials for rheumatoid arthritis
The role of microparticles as biomarkers in the development of therapy for autoimmune disease
Part II. Genomic Medicine
The future of genomic medicine in inflammatory diseases
Part III. Bispecific Antibodies
Bispecific antibodies
Part IV. Cross-Functional Targers
Targeting CD13 with Asn-Gly-Arg (NGR) peptie-drug conjugates
Energy homeostasis of immune cells: transplanting cell bioenergetics into clinical application in rheumatoid arthritis
The intestinal microbiome, the immune system, and spondyloarthropathy
Stem cell therapy in the treatment of rheumatic diseases and application in the treatment of systemic lupus erythematosus
Index.

Contents:
Doctor-patient relationships and our expectations
The forces impacting doctor-patient relationships and our expectations
Retail thinking comes to health care : the patient as consumer
All roads lead to trust : how doctors see the relationship and our expectations
The tyranny of lowered expectations : how patients see the relationship
Ceding care to the corporation : making doctors disappear
Saving the doctor-patient relationship and raising expectations
Appendix : how the study was conducted.

Summary: "For the last 100,000 years, we Sapiens have accumulated enormous power. But despite all our discoveries, inventions, and conquests, we now find ourselves in an existential crisis. The world is on the verge of ecological collapse. Misinformation abounds. And we are rushing headlong into the age of AI-a new information network that threatens to annihilate us. For all that we have accomplished, why are we so self-destructive? Nexus looks through the long lens of human history to consider how the flow of information has shaped us, and our world. Taking us from the Stone Age, through the canonization of the Bible, early modern witch-hunts, Stalinism, Nazism, and the resurgence of populism today, Yuval Noah Harari asks us to consider the complex relationship between information and truth, bureaucracy and mythology, wisdom and power. He explores how different societies and political systems throughout history have wielded information to achieve their goals, for good and ill. And he addresses the urgent choices we face as non-human intelligence threatens our very existence"-- Provided by publisher.

Contents:
What is information?
Stories : unlimited connections
Documents : the bite of the paper tigers
Errors : the fantasy of infallibility
Decisions : a brief history of democracy and totalitarianism
The new members : how computers are different from printing presses
Relentless : the network is always on
Fallible : the network is often wrong
Democracies : can we still hold a conversation?
Totalitarianism : all power to the algorithms?
The silicon curtain : global empire or global split?

Summary: "Nice Racism asserts that it is white progressives who are responsible for inflicting the most daily harm on people of color"-- Provided by publisher. DiAngelo identifies many common white racial patterns and breaks down how well-intentioned white people unknowingly perpetuate racial harm. She explains how spiritual white progressives seek community by co-opting Indigenous and other groups' rituals create separation, not connection. Challenging the ideology of individualism, DiAngelo explains why it is OK to generalize about white people, and she demonstrates how white people who experience other oppressions still benefit from systemic racism. -- adapted from jacket

Contents:
Introduction
What is a nice racist?
Why it's OK to generalize about White people
There is no choir
What's wrong with niceness?
The moves of White progressives
Spiritual, not religious
Let's talk about shame
What about my trauma?
We aren't actually that nice
How White people who experience other oppressions can still be racist, or "But I'm a minority myself!"
How do you make a White progressive a better racist?
Niceness is not courageous: how to align your professed values with your actual practice.

Summary: As the Civil Rights movement begins to reach the black enclave of Frenchtown in segregated Tallahassee, Elwood Curtis takes the words of Dr. Martin Luther King to heart: He is "as good as anyone." Abandoned by his parents, but kept on the straight and narrow by his grandmother, Elwood is about to enroll in the local black college. But for a black boy in the Jim Crow South of the early 1960s, one innocent mistake is enough to destroy the future. Elwood is sentenced to a juvenile reformatory called the Nickel Academy, whose mission statement says it provides "physical, intellectual and moral training" so the delinquent boys in their charge can become "honorable and honest men." In reality, the Nickel Academy is a grotesque chamber of horrors where the sadistic staff beats and sexually abuses the students, corrupt officials and locals steal food and supplies, and any boy who resists is likely to disappear "out back." Stunned to find himself in such a vicious environment, Elwood tries to hold onto Dr. King's ringing assertion "Throw us in jail and we will still love you." His friend Turner thinks Elwood is worse than naive, that the world is crooked, and that the only way to survive is to scheme and avoid trouble. The tension between Elwood's ideals and Turner's skepticism leads to a decision whose repercussions will echo down the decades. Formed in the crucible of the evils Jim Crow wrought, the boys' fates will be determined by what they endured at the Nickel Academy.

Summary: Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Tourette's syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.

Summary: This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This book is published with open access under a CC BY 4.0 license.

Contents:
1. Overview
2. In vivo imaging of nicotinic acetylcholine receptors in the central nervous system
3.A new aspect of cholinergic transmission in the central nervous system
4. Nicotinic acetylcholine receptor signaling: roles in neuroprotection
5. Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection
6. Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans
7. Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders
8. Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer's and Parkinson's diseases
9. SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors
10. Removal of blood amyloid as a therapeutic strategy for Alzheimer's disease: the influence of smoking and nicotine.

Summary: Parents of babies in the NICU will become more informed partners in care with this essential resource. This fully revised and updated journal provides educational content and a way to monitor their baby's progress. The journal includes helpful information on common questions about the NICU, offers tips on coping, and provides helpful checklists to help parents stay organized and informed while in the NICU.

Contents:
General NICU considerations / Megan Lunberry and Miyuki Nakayama Shouse
Developmental pharmacology, pharmacokinetics, and pharmacodynamics / John Brock Harris
Total parenteral nutrition / Ying-Tang Ng
Drugs in lactation / Amy P. Holmes
Neonatal abstinence syndrome / Amy P. Holmes
Apnea of prematurity / John Brock Harris
Respiratory distress syndrome and bronchopulmonary dysplasia / Julia Lau
Patent ductus arteriosus / Betsy Walters Burkey
Pain and sedation / Ashley McCallister and Amy P. Holmes
Neonatal bacterial sepsis and meningitis / John Brock Harris
TORCH infections / Amy P. Holmes
Respiratory syncytial virus / Betsy Walters Burkey and Michelle F. F. Poole
Necrotizing enterocolitis / John Brock Harris
Gastrointestinal disorders / John Brock Harris
Vaccine use in infants / Amy P. Holmes
Pulmonary hypertension / Julia Lau
Neonatal seizures / John Brock Harris
Extracorporeal membrane oxygenation / Wyn Wheeler.

Summary: The modern-day practice of health care was imported into Nigeria over 500 years ago. In 1947, the first national health plan was developed in Nigeria with the primary goal of providing universal health care (UHC), but this goal remains elusive to date. This comprehensive book presents the roadmap needed to attain UHC in Nigeria and offers a blueprint for achieving high-quality health care in the nation. Starting with a brief overview of the Nigerian state, the fundamentals of health care, including the challenges to affordable quality healthcare delivery, the author critically examines the healthcare system in Nigeria and offers specific recommendations to invigorate the system and improve interprofessional collaborations. Each chapter includes case studies to allow readers to contextualize the information presented and behavioral learning objectives to test readers' knowledge. Among the topics covered: The Organizational Structure and Leadership of the Nigerian Healthcare System The Vulnerabilities of the Nigerian Healthcare System The Spectrum of Complementary and Alternative Medicine Emerging Developments in Traditional Medicine Practice in Nigeria The Plight of Persons Living with Disabilities: The Visible Invisibles in Nigeria A Comparative Analysis of the Health System of Nigeria and Six Selected Nations Around the World A Qualitative Investigation of the Barriers to the Delivery of High-Quality Healthcare Services in Nigeria The Political and Economic Reforms Needed to Achieve Universal and High-Quality Health Care in Nigeria Reimagining the Nigerian Healthcare System to Achieve Universal and High-Quality Health Care by 2030 The Nigerian Healthcare System: Pathway to Universal and High-Quality Health Care is ideal for adoption as a textbook in health services administration, health policy and management, health informatics, healthcare delivery systems, and primary health care courses offered at universities in Nigeria. It also would appeal to students and faculty in African diaspora programs internationally. The book is also essential for policymakers, health systems technocrats, researchers, and professionals in various health disciplines, including medicine, nursing, and allied health.

Contents:
Intro
Foreword
Preface
Acknowledgments
Contents
About the Author
Abbreviations
Chapter 1: Introduction
Overview of the Nigerian State
Geography and Politics
Ethnicity
Religion
Economy
Income Inequity
Health System
Overview of the Chapters
Competition and Conclusion
References
Chapter 2: The Fundamentals of Health Care
Introduction
What Is Health?
Determinants of Health
Health Equity
Health Disparities and Health Inequalities
Health in All Policies
Is Health a "Consumption Good" or an "Investment Good"? Relationship Between Health and Development
United Nations Development Goals
Global Access to Health Care
Burden of Disease
Life Expectancy
Hand Hygiene in Healthcare Settings
The Global Burden of Healthcare-Associated Infections
Measuring Healthcare Outcomes
Assessment of Quality of Health Care
Framework for Monitoring Performance of Health Systems
Recent Advances and Innovations in Health Care
Healthcare Financing Models
Conclusion
References
Chapter 3: The Evolutionary Developments, Threats and Opportunities Within the Nigerian Healthcare System Introduction
Critical Milestones in the Development of Western-Style Healthcare System (1472-2019)
The Current State of the Nigerian Health System (2019-2021)
Health Outcome Indicators
The National Health Insurance Scheme Debacle
Present and Future Threats to the Health System
Opportunities Within the Health System
Performance of Health System in African Countries
Conclusion
References
Chapter 4: The Organizational Structure and Leadership of the Nigerian Healthcare System
Introduction
Operational Definitions Organization Structure of the Federal Ministry of Health
Healthcare System Structure
Impact of the Private Sector in Health Service Delivery
Conventional Medicine Private Health Care
Traditional Medicine Private Health Care
Management and Leadership of the Health Departments
Leadership of the Federal Ministry of Health
The Functions of the Health Minister and Skills Needed to Be Successful
The Controversy Over the Surgeon General Position
Conclusion
References
Chapter 5: The Vulnerabilities of the Nigerian Healthcare System
Introduction
Methodology Health System Vulnerabilities
Vulnerability #1: Poor Governance and Ineffective Leadership
Vulnerability #2: Low-Quality Health Service Delivery
Vulnerability #3: Shortage of Healthcare Workforce
Vulnerability #4: Paltry Health Systems Financing
Vulnerability #5: Limited Access to Essential Medicines and Vaccines
Vulnerability #6: Weak Health Information Systems
Major Achievements and Contributions of Nigeria to Global Health
Genesis of Primary Health Care and Itinerant/Community-Based Physiotherapy Systems
Community Health Workers
Medical and Surgical Discoveries

Summary: "A dazzling, unforgettable novel about a young Black woman who walks the streets of Oakland and stumbles headlong into the failure of its justice system--a debut that announces a blazingly original voice. Kiara Johnson and her brother Marcus are barely scraping by in a squalid East Oakland apartment complex that calls itself, optimistically, the Royal-Hi. Both have dropped out of high school, their family fractured by death and prison. But while Marcus clings to his dream of rap stardom, Kiara hunts for work to pay their rent--which has now more than doubled--and to keep the 9-year-old boy next door, abandoned by his mother, safe and fed. What begins as a drunken misunderstanding with a stranger one night soon becomes the job Kiara never wanted but now desperately needs: nightcrawling. And her world breaks open even further when her name surfaces in an investigation that exposes her as a key witness in a massive scandal within the Oakland police department. Full of edge, raw beauty, electrifying intensity, and piercing vulnerability, Nightcrawling marks the stunning arrival of a voice unlike any we have heard before"-- Provided by publisher

Summary: Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Contents:
PART 1
Immunity Initiation, Propagation and Resolution of Inflammation.- Haematopoeisis and lymphocyte development: an introduction.- T cell subsets and T-cell mediated immunity.- Antibody diversity and B-cell mediated immunity.- Dendritic cells.- Cytokines.- Epigenetic regulation of immunity.- Innate immunity: phagocytes, NK cells, and and humoral defence.- Inflammatory mediators and intracellular signalling.- Immune response in human pathology: infections caused by bacteria, viruses, fungi, and parasites.- Immune response in human pathology: hypersensitivity and autoimmunity.- Cancer immunity.- Neuroimmunoendocrinology. PART 2
Immunodiagnosis Antibody detection.- Immunoassays.- Flow cytometry.- Microarrays.- Imaging Inflammation.- PART 3
Immunotherapeutics.- Vaccines and adjuvants.- Plasma-derived immunoglobulins.- Monoclonal antibodies for the treatment of immune.- Anti-allergic drugs.- Drugs for the treatment of airway disease.- Immunotherapy in the management of asthma and other allergic conditions.- Immunostimulants in cancer therapy.- Immunomodulation in sepsis and infection.- Immunopharmacology of probiotics and prebiotics.- Mild plant and dietary immunomodulators.- Influence of antibacterial drugs on the immune system.- Cytotoxic drugs.- Immunosuppressives in transplant rejection.- Corticosteroids.- Non-steroidal anti-inflammatory drugs.- Disease-modifying antirheumatic drugs.- Drugs for soft tissue autoimmune disorders.- Cell and gene therapy of immune disorders.- PART 4
Immunotoxicology Immunotoxicology 2017.

Summary: This book describes nitric oxide (NO) and hydrogen peroxide (H2O2) functions in higher plants. Much progress has been made in the field of NO and H2O2 research regarding the various mechanisms and functions of these two molecules, particularly regarding stress tolerance and signaling processes, but there are still gaps to be filled. NO and H2O2 are both crucial regulators of development, and act as signaling molecules at each step of the plant lifecycle, while also playing important roles in biotic and abiotic responses to environmental cues. The book summarizes key advances in the field of NO and H2O2 research, focusing on a range of processes including: signaling, metabolism, seed germination, development, sexual reproduction, fruit ripening, and defense.

Contents:
Hydrogen peroxide and nitric oxide generation in plant cells : overview and queries
Hydrogen peroxide and nitric oxide signaling network
Hydrogen peroxide (H₂O₂)-and nitric oxide (NO)-derived posttranslational modifications
Transcriptional regulation of gene expression related to hydrogen peroxide (H₂O₂) and nitric oxide (NO)
Metabolism and interplay of reactive oxygen and nitrogen species in plant mitochondria
Hydrogen peroxide and nitric oxide metabolism in chloroplasts
Participation of hydrogen peroxide and nitric oxide in improvement of seed germination performance under unfavorable conditions
Nitric oxide and hydrogen peroxide in root organogenesis
Nitric oxide and hydrogen peroxide : signals in fruit ripening
Plant abiotic stress : function of nitric oxide and hydrogen peroxide
Nitric oxide and hydrogen peroxide in plant response to biotic stress
Biotechnological application of nitric oxide and hydrogen peroxide in plants.

Summary: Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions.

Summary: This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Contents:

v. 1. Introduction to the nitrofurans.

Summary: "This book is written primarily for students and residents in general surgery. It is meant to serve as an introduction to the field of surgery, rather than a comprehensive review. In this edition, we have re-organized the overall structure. First and foremost, we reduced the size to fit in a lab coat pocket, so you can carry it with you for quick reference. Accordingly, we pared down some of the text to focus on the essential information. New features to this edition include "Trusted Sources," which are links to non-commercial websites and other sources of up-to-date details and practice guidelines on relevant topics. We have also aimed to create more alignment with the NMS Surgery Casebook. This involved changing the order of the chapters from the previous edition and adding "Cut to Casebook" cross-references to make it easier to find the appropriate cases to complement the textbook. We have also revised the outline of each chapter to open with highlights, called "Chapter Cuts." The key points are immediately followed by "Critical Surgical Associations," which provide triggers for medical students to remember important connections in the surgical thought process. For the tremendous work put into this edition, we thank the individual contributors. Their highquality and frequently punctual contributions have made our jobs as editors pleasant. We are also grateful to the editorial team at Wolters Kluwer for their guidance and support throughout the Process"-- Provided by publisher.

Summary: "The cases in this book represent how surgeons think and make decisions about clinical problems. We have attempted to write it in a way that allows us to "talk to you" as you read it, so that the book will be the next best thing to teaching in person. The cases are organized by systems address the common presentations of clinical problems. The history and physical examination clues, radiologic images, and other figures help you formulate a differential and ultimately a diagnosis. Case variations are also presented to help you consider the appropriate treatment of patients with various complications and coexisting conditions"-- Provided by publisher. "Lippincott® Connect Featured TitlePurchase the new print edition of this Lippincott® Connect title includes lifetime access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments.Ideal as a stand-alone review or as a perfect companion to NMS Surgery, Seventh Edition, this leading casebook for the surgical rotation presents a series of surgical cases that begin with a clinical scenario and progress step by step through the decision-making process of patient management. Concise and portable, NSM Surgery Casebook, Third Edition fits in a lab coat pocket-ideal for review on the wards.Retaining the structured subject review, practice questions for the USMLE Step 2 exam, and focus on helping students work through clinical cases with a unique "what next" approach to decision making, this third edition offers a new full-color design, new study aids, and key updates throughout.A unique, case-based surgical review, with case variations, teaches effective surgical approach and allows students to practice real-world clinical decision making and prepare for exams.New and updated cases reflect modern surgical practice.Revised Cutting to the Chase feature at the beginning of each chapter presents a high-yield overview of important concepts.New Critical Surgical Associations from NMS Surgery cover associations and important sequences in a highly visual way.All-new radiographic images are easier to read and interpret.Easy-to-spot Digging Deep boxes provide high-yield information in an easily accessible way.An extensive illustration program provides opportunities to make patient management decisions based on visual cues.Lippincott® Connect features: Lifetime access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience.Carefully curated resources, including interactive diagrams, video tutorials, flashcards, organ sounds, and self-assessment, all designed to facilitate further comprehension.Lippincott® Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics.Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material.Annotate and highlight key content for easy access later.Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page"-- Provided by publisher.

Contents:
Preoperative care / Bruce E. Jarrell, Molly Buzdon, Daniel Bochicchio, Eric D. Strauch
Postoperative care / Bruce E. Jarrell, Molly Buzdon, Eric D. Strauch
Wound healing / Bruce E. Jarrell, Eric D. Strauch
Thoracic and cardiothoracic disorders / Bruce E. Jarrell, Joseph S. MacLaughlin, Eric D. Strauch
Vascular disorders / Bruce E. Jarrell, Marshall Benjamin, Eric D. Strauch
Upper gastrointestinal tract disorders / Bruce E. Jarrell, John L. Flowers, Molly Buzdon, Eric D. Strauch
Pancreatic and hepatic disorders / Bruce E. Jarrell, Eric D. Strauch
Lower gastrointestinal disorders / Bruce E. Jarrell, Molly Buzdon, Daniel Bochicchio
Endocrine disorders / Bruce E. Jarrell, W. Bradford Carter
Skin and soft tissue disorders and hernias / Bruce E. Jarrell
Breast disorders / Bruce E. Jarrell, Emily Bellavance, Michelle Townsend-Watts, Katherine Tkaczuk, Eric D. Strauch
Trauma, burns, and sepsis / Bruce E. Jarrell, Thomas Scalea, Molly Buzdon
Congenital anomalies / Clint D. Cappiello, Eric D. Strauch, Bruce E. Jarrell.

Summary: "In No Perfect Birth: Trauma and Obstetric Care in the Rural United States, Kristin Haltinner examines the institutional and ideological forces that cause harm to women in childbirth in the rural United States"-- Provided by publisher.

Summary: This book is a tribute to early pioneers and later innovators in applications of surgical principles for biliary stone disease. It is written as a challenge to all surgeons applying these principles to approach the biliary system with the safest and most appropriate technical support. This book is also written as a challenge to all those involved in the training of future generations of surgeons in the hope that critical standards in biliary surgical management will be promulgated and highlighted. The text contains knowledge from surgical leaders who played a vital part in the modern management of biliary stone disease. These contributions include their perceptions, wisdom and recommendations for the future. In doing so, the authors aim to discover ways to make the surgical management of biliary stone disease even better. This volume, thoughtfully curated by two eminent surgical scholars, provides perhaps the most complete history of the field. Dr. Berci and Dr. Greene enlisted a remarkable panel of distinguished colleagues from around the world to discuss every important element of surgical practice. These elements include: The resourcefulness of developing novel optics and instruments on the fly, the integration of new imaging capabilities into pre-operative assessments and intraoperative management, the challenge of educating prideful senior surgeons who were ill at ease with the distance imposed by a laparoscope, and the introduction of progressively more elegant ex vivo modules to train inexperienced juniors with limited open operative experience. Finally, it also discusses the never-ending task of ensuring the safety of one of the most common operations performed in the world, yet one with a persistent, if small, risk of life altering injury to the biliary ducts. No Stones Left Unturned aims to build on a classic surgical text and then discusses the issues faced by surgeons performing biliary surgery in the modern era. It serves as a valuable resource for surgeons, practicing clinicians, surgical residents, and fellows that wish to apply this knowledge and improve upon the current standards of biliary surgical management.

Contents:
Intro
Preface
Acknowledgement
Introduction
Contents
Contributors
Part I: Kehr and His Textbook
1: The History of Biliary Stone Disease
References
2: Professor Dr. Hans Kehr (1862-1916)
References
3: Translation of Professor Dr. Hans Kehr
Instruments
Description of Surgical Cases (Bilingual) Translation
4: The Anatomy and Variations of Important Structures
5: Biliary Stones
Summarized Case Report
Gallbladders with Carcinomas
Preoperative Position
6: Surgery
Summarized Detail of 68 Operated Cases
Mortality: 7 Cases (9.3%) Part II: The Gallbladder and Adjacent Structures
7: History of Endoscopy
Maximilian Nitze (1849-1906), Germany
Hans Christian Jacobeus [2] (1879-1937), Sweden
References
8: Early Biliary Surgeons
References
9: Early American Surgeons
References
10: Endoscopy
References
11: Laparoscopy
Heinz Kalk (1895-1973), Germany
John Ruddock (1891-1964), USA
References
12: Advances in Visualization for Laparoscopic Surgery
References
13: Laparoscopic Cholecystectomies
References
14: Cholangiography in the Operating Room Standard Operative Cholangiography [6]
Operative Fluoro-Cholangiography
Benefits of the Cholangiogram
Biliary Ductal Anatomy
Biliary Duct Stones
References
15: Bile Duct Injuries
References
16: Common Bile Duct Stones and Choledocholithotomy
CBD Stones
References
Publications
ERCP USA
ERCP International
17: Laparoscopic Cholecystectomy: Introduction, Uptake, Maturity, and Impact on Surgical Practice-Personal Reflections from the Shop Floor
Introduction
Nomenclature and Origin of Laparoscopic Surgery/Cholecystectomy
General Considerations Initial Nosocomial Surgical Epidemic
Techniques of Laparoscopic Cholecystectomy
Patients with Symptomatic Gallstones and Ductal Calculi
Day Case/Ambulatory LC
Bleeding Complications Associated with LC
Training and Simulation
Impact of LC on Surgical Practice across the Specialties
Advent of Robotically Assisted Laparoscopic Surgery
What Next?
References
Part III: Commentaries
18: Commentaries
Commentary
Teaching the Laparoscopic Common Bile Duct Exploration to Acute Care Surgeons
Commentary: Berci-Greene "No Stones Left Unturned" Kehr Book The Trajectory of Biliary Surgery: Personal Reflections
Commentary
Laparoscopic Cholecystectomy: At the Beginning...1989-1990
Personal Perspective/Experience-In This Surgical Space
Historical Context: The Early Pioneers
Recent Developments and We "Late Comers"
Convergence of Disciplines
Disruptive Technologies
Current State
Surgical Training
Final and Future Thoughts
Each Major Advance in Biliary Surgery Needed a New Way of Teaching
Biliary Surgery: A Story of Innovation and Change
Commentary
For Me, It Started with Diagnostic Laparoscopy
Commentary