BookPiotr Rutkowski, Mario Mandalà, editors.
Summary: This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research. This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information. Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.
Contents:
Pathology of Melanoma and Skin Carcinomas
Molecular Landscape Profile of Melanoma
Molecular Landscape of Skin Carcinomas
Immunological Features of Melanoma
Dabrafenib and Trametinib
Vemurafenib and Cobimetinib
Encorafenib and Binimetinib
Vismodegib
Sonidegib
Ipilimumab
Nivolumab
Pembrolizumab
Talimogene Leharparepvec
Perspectives of Immunotherapy in Advanced Melanoma Combinations and Sequencing
Avelumab
Cemiplimab
Perspectives of Immunotherapy in Non-Melanoma Skin Cancers
Mechanisms of Resistance to Targeted Therapies in Skin Cancer
Mechanisms of Resistance to Immunotherapy
Neoadjuvant and Adjuvant Therapy in Melanoma
Adoptive Cell Therapy
Immunotherapy in Immunosuppressed Patients
New Therapies in Advanced Cutaneous Malignancies: Conclusions.