Lane Medical Library

Complicated shadows : a critique of autonomy in genetic counseling / Robert G. Resta -- Actively engaging with patients in decision making / Andrea Zanko and Michelle Fox -- Risk communication : a complex process / Shannan DeLany Dixon and Yasmine L. Konheim-Kalkstein -- Grieving : an inevitable journey / Elizabeth Gettig -- Facing patient anger / Bonnie Jeanne Baty -- Resistance and adherence : understanding the patient's perspective / Jon Weil -- Countertransference : making the unconscious conscious / Jon Weil -- Honoring diversity : cultural competence in genetic counseling / Linwood J. Lewis -- Genetic counseling strategies for working with families / Deborah L. Eunpu -- Developmentally based approaches for counseling children and adolescents / Stephanie Austin -- Genetic counseling for women with intellectual disabilities / Brenda Finucane -- Genetic counselors : caring mindfully / June A. Peters -- Professional development : reflective genetic counseling practice / Kimberly W. Zahm -- Mobilizing genetic counselor leadership skills / Nancy P. Callanan.

Introduction : the scope and importance of genetic democracy /Veikko Launis --The prerequisites for genetic democracy /Helena Siipi --Ethical expertise in democratic societies /Eerik Lagerspetz --Towards global bioethics : the UNESCO universal declaration on bioethics and human rights /Henk ten Have --Autonomy and genetic privacy /Juha Räikkä --Values, rights and GMO : against radicalism --The precautionary principle and the risks of modern agri-biotechnology /Marko Ahteensuu --Population databanks and democracy in light of the Icelandic experience /Vilhjálmur Árnason and Stefán Hjörleifsson --Equality and community in public deliberation : genetic democracy in Taiwan /Terence Hua Tai and Wen-Tsong Chiou --Genetic resources, genetic democracy and genetic equity /Keekok Lee --Moral constraints on permissible genetic design /Thomas Pogge.

Mechanisms of mutation -- Pancreas - Genetic testing in diabetes mellitus: a clinical guide to monogenic diabetes -- Obesity -- Syndromes of severe insulin resistance and/or lipodystrophy -- Pituitary -- Functioning pituitary adenomas -- Diabetes insipidus -- States of pituitary hypofunction -- Thyroid -- Congenital defects of thyroid hormone synthesis -- Developmental abnormalities of the thyroid -- Syndromes of reduced sensitivity to thyroid hormone -- Molecular genetics of thyroid cancer: pathogenetic significance and clinical applications -- Parathyroid and bone -- Genetics of hyperparathyroidism including parathyroid cancer -- Genetic diagnosis of skeletal dysplasias -- Vitamin D disorders -- Adrenal -- Congenital adrenal hyperplasia -- Genetics of adrenocortical tumors (ACT) and hypersecretory syndromes -- Hereditary pheochromocytoma and multiple endocrine neoplasia type 2 (MEN2) -- Genetic conditions associated with congenital adrenocortical insufficiency or glucocorticoid and/or mineralocorticoid resistance -- Reproductive -- Genetic considerations in the evaluation of menstrual cycle irregularities -- Genetic diagnosis of hypogonadotropic hypogonadism and Kallmann syndrome -- Disorders of sex development -- Genetic defects of androgen resistance -- Multisystem disorders -- Multiple endocrine neoplasia type 1 (MEN1) -- Genetics of polyglandular failure -- Growth -- Genetic diagnosis of growth failure -- Counseling and laboratory -- Genetic counseling -- Setting up a laboratory.

Introduction : whither gene-environment interactions? ? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin -- Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman -- Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge -- Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson -- Longitudinal studies of gene-environment interaction in common diseases - good value for money? / Stephen P. Robertson and Richie Poulton -- Gene-environment interactions in breast cancer / Kee-Seng Chia -- Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu -- Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho -- Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez -- Conclusions : taking stock and looking ahead / Michael Rutter.

Molecular Genetics and Genetic Variation / Mohammed-Elfatih Twfieg, M. Dawn Teare -- Terminology, Concepts, and Models in Genetic Epidemiology / M. Dawn Teare, Mauro F. Koref -- An Introduction to Epidemiology / Cother Hajat -- Genetic Distance and Markers Used in Linkage Mapping / Kristina Allen-Brady, Nicola J. Camp -- Approaches to Genetic Linkage Analysis / M. Dawn Teare -- Fine-Scale Structure of the Genome and Markers Used in Association Mapping / Karen Curtin, Nicola J. Camp -- Genome-Wide Association Studies / Mark M. Iles -- Candidate Gene Association Studies / M. Dawn Teare -- Family-Based Association Studies / Frank Dudbridge -- Genome Variation: A Review of Web Resources / Andrew Collins, William J. Tapper -- Advanced Methods in Twin Studies / Jaakko Kaprio, Karri Silventoinen -- Mendelian Randomisation: A Tool for Assessing Causality in Observational Epidemiology / Nuala A. Sheehan, Sha Meng, Vanessa Didelez -- Copy Number Variation / Louise V. Wain, Martin D. Tobin -- Epigenetic Variation / Kevin Walters -- Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis / Hervé Perdry, Françoise Clerget-Darpoux -- Coronary Artery Disease: An Example Case Study / Jennifer H. Barrett -- The Genetic Epidemiology of Obesity: A Case Study / Laura M. Johnson.

Overview. Overview of the field / Tetsuo Ashizawa and Robert D. Wells -- Myotonic dystrophy. Myotonic dystrophies: an overview / Tetsuo Ashizawa and Peter S. Harper. The RNA-mediated disease process in myotonic dystrophy / Charles A. Thornton, Maurice S. Swanson, and Thomas A. Cooper. cis Effects of CTG expansion in myotonic dystrophy type 1 / Sita Reddy and Sharan Paul. Normal and pathophysiological significance of myotonic dystrophy protein kinase / Derick G. Wansink, René E.M.A. van Herpen, and Bé Wieringa. Biochemistry of myotonic dystrophy protein kinase / Ram Singh and Henry F. Epstein. Clinical and genetic features of myotonic dystrophy type 2 / Jamie M. Margolis, Laura P.W. Ranum, and John W. Day. Myotonic dystrophy type 2: clinical and genetic aspects / Ralf Krahe, Linda L. Bachinski, and Bjarne Udd. The subtelomeric D4Z4 repeat instability in facioscapulohumeral muscular dystrophy / Silvére van der Maarel, Rune R. Frants, and George W. Padberg -- Fragile X syndrome. Fragile X syndrome and fragile X-associated tremor/ataxia syndrome / Randi J. Hagerman and Paul J. Hagerman. Animal models of fragile X syndrome: mice and flies / Ben A. Oostra and David L. Nelson. Chromosomal fragile sites: mechanisms of cytogenetic expression and pathogenic consequences / Robert I. Richards -- Kennedy's disease. Clinical features and molecular biology of Kennedy's disease / CheunJu Chen and Kenneth H. Fischbeck -- Huntington's disease. Molecular pathogenesis and therapeutic targets in Huntington's disease / John S. Bett, Gillian P. Bates, and Emma Hockly. Molecular pathogenesis of Huntington's disease: the role of excitotoxicity / Mahmoud A. Pouladi ... [et al.] Huntington's disease-like 2 / Russell L. Margolis ... [et al.] -- Friedreich's ataxia. Friedreich's ataxia / Massimo Pandolfo. Experimental therapeutics for Friedreich's ataxia / Robert B. Wilson. Evolution and instability of the GAA triplet-repeat sequence in Friedreich's ataxia / Irene De Biase, Astrid Rasmussen, and Sanjay I. Bidichandani. Mouse models for Friedreich's ataxia / Hélène Puccio. Triplexes, sticky DNA, and the (GAA-TTC) trinucleotide repeat associated with Friedreich's ataxia / Leslie S. Son and Robert D. Wells -- Spinocerebellar ataxias. Phosphorylation of ataxin-1: a link between basic research and clinical application in spinocerebellar ataxia type 1 / Kerri M. Carlson and Harry T. Orr. Spinocerebellar ataxia type 2 / Stefan M. Pulst. Machado-Joseph disease/spinocerebellar ataxia type 3 / Henry Paulson. Spinocerebellar ataxia type 6 / Hidehiro Mizusawa and Kinya Ishikawa. Pathogenesis of spinocerebellar ataxia type 7: new insights from mouse models and ataxin-7 function / Dominique Helmlinger and Didier Devys. Spinocerebellar ataxia type 7: clinical features to cellular pathogenesis / Gwenn A. Garden ... [et al.] Molecular genetics of spinocerebellar ataxia type 8 / Yoshio Ikeda ... [et al.] Spinocerebellar ataxia type 10: a disease caused by an expanded (ATTCT)n pentanucleotide repeat / Tetsuo Ashizawa. DNA structures and genetic instabilities associated with spinocerebellar ataxia type 10 (ATTCT)n·(AGAAT)n repeats suggest a DNA amplification model for repeat expansion / Vladimir N. Potman ... [et al.] Spinocerebellar ataxia type 12 / Susan E. Holmes ... [et al.] Spinocerebellar ataxia 17 and Huntington's disease-like 4 / Giovanni Stevanin and Alexis Brice -- Other polyamino acid repeats. Polyalanine and polyglutamine diseases: possible common mechanisms? / Aida Abu-Baker and Guy A. Rouleau -- Biophysics of polyQ. Chemical and physical properties of polyglutamine repeat sequences / Ronald Wetzel -- In vivo instability studies. Somatic mosaicism of expanded CAG·CTG repeats in humans and mice: dynamics, mechanisms, and consequences / Peggy F. Shelbourne and Darren G. Monckton. Transgenic mouse models of unstable trinucleotide repeats: toward an understanding of disease-associated repeat size mutation / Mário Gomes-Pereira, Laurent Foiry, and Geneviève Gourdon -- Insect models. Drosophila models of polyglutamine disorders / George R. Jackson, Tzu-Kang Sang, and J. Paul Taylor -- Instability mechanisms in vivo and in vitro. Involvement of genetic recombination in microsatellite instability / Ruhee Dere, Micheal L. Hebert, and Marek Napierala. Bending the rules: unusual nucleic acid structures and disease pathology in the repeat expansion diseases / Karen Usdin. Replication of expandable DNA repeats / Sergei M. Mirkin. Error-prone repair of slipped (CTG)·(CAG) repeats and disease-associated expansions / Gagan B. Panigrahi ... [et al.] DNA repair models for understanding triplet repeat instability / Yuan Liu, Rajendra Prasad, and Samuel H. Wilson. Models of repair underlying trinucleotide DNA expansion / Irina V. Kovtun and Cynthia T. McMurray. Transcription and triplet repeat instability / Yunfu Lin, Vincent Dion, and John H. Wilson. Structural characteristics of trinucleotide repeats in transcripts / Wlodzimierz J. Krzyzosiak, Krzysztof Sobczak, and Marek Napierala -- Mutations in flanking sequences. Gross rearrangements caused by long triplet and other repeat sequences / Albino Bacolla [et al.] -- Cancer and genetic instability. Microsatellite instability in cancer / Michael J. Siciliano.

Immunomagnetic enrichment of human and mouse hematopoietic stem cells for gene therapy applications / Guillermo Guenechea, Jose C. Segovia, and Juan A. Bueren -- Isolation of human and mouse hematopoietic stem cells / Yuk Yin Ng ... [et al.] -- Murine hematopoietic stem cell transduction using retroviral vectors / Ute Modlich ... [et al.] -- Genetic modification of human hematopoietic cells: preclinical optimization of oncoretroviral-mediated gene transfer for clinical trials / Tulin Budak-Alpdogan and Isabelle Rivière -- Short-term culture of human CD34⁺ cells for lentiviral gene transfer / Francesca Santoni de Sio and Luigi Naldini -- T cell culture for gammaretroviral transfer / Sebastian Newrzela, Gunda Brandenburg, and Dorothee von Laer -- Retroviral transduction of murine primary T lymphocytes / James Lee, Michel Sadelain, and Renier Brentjens -- Lentiviral vector gene trasfer into human T cells / Els Verhoeyen, Caroline Costa, and Francois-Loic Cosset -- DNA transposons for modification of human primary T lymphocytes / Xin Huang ... [et al.] -- Retroviral gene transfer into primary human natural killer cells / Evran Alici, Tolga Sutlu, and M. Sirac Dilber -- Lentiviral vector-mediated genetic programming of mouse and human dendritic cells / Renata Stripecke --In situ (in vivo) gene transfer into murine bone marrow stem cells / Dao Pan -- In vivo and ex vivo gene transfer in thymocytes and thymocyte precursors / Oumeya Adjali ... [et al.] -- Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells / Axel Schambach, William P. Swaney, and Johannes C.M. van der Loo -- Knock-down of gene expression in hematopoietic cells / Michaela Scherr, Letizia Venturiani, and Matthias Eder -- The use of retroviral vectors for tet-regulated gene expression in cell populations / Rainer Löw -- Detection of replication competent retrovirus and lentivirus / Lakshmi Sastry and Kenneth Cornetta -- Release testing of retroviral vectors and gene-modified cells / Diana Nordling, Anne Kaiser, and Lilith Reeves -- Copy number determination of genetically-modificed hematopoietic stem cells / Todd Schuesler ... [et al.] -- Tissue procurement for molecular studies using laser-assisted microdissection / Ulrich Lehmann and Hans Kreipe -- Leukemia diagnosis in murine bone marrow transplantation models / Zhixiong Li, Ute Modlich, and Anjali Mishra --Humanized mouse models to study the human haematopoietic stem cell compartment / Dominique Bonnet -- Canine models of gene-modified hematopoiesis / Brian C. Beard and Hans-Peter Kiem -- Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples / Manfred Schmidt ... [et al.] -- Retroviral insertion site analysis in dominant haematopoietic clones / Olga S. Kustikova, Ute Modlich, and Boris Fehse -- Tracking gene-modified T cells in vivo / Alessandra Recchia and Fulvio Mavilio -- DNA microarray studies of hematopoietic subpopulations / Karin Pike-Overzet ... [et al.] -- Quantification of genomic mutations in murine hematopoietic cells / Hartmut Geiger ... [et al.] -- Proteomics studies after hematopoietic stem cell transplantation / Eva M. Weissinger, Petra Zürbig, and Arnold Ganser -- Spectral karyotyping and fluorescence in situ hybridization of murine cells / Cornelia Rudolph and Brigitte Schlegelberger -- Database setup for preclinical studies of gene-modified hematopoiesis / Brenden Balcik, Elke Grassman, and Lilith Reeves -- The US and EU regulatory perspectives on the clinical use of hematopoietic stem/progenitor cells genetically modified ex vivo by retroviral vectors / Carolyn A. Wilson and Klaus Cichutek.

Determination of mitotic recombination rates by fluctuation analysis in Saccharomyces cerevisiae / Rachelle Miller Spell and Sue Jinks-Robertson -- Determination of intrachromosomal recombination rates in cultured mammalian cells / Jason A. Smith and Alan S. Waldman -- Intrachromosomal homologous recombination in Arabidopsis thaliana / Waltraud Schmidt-Puchta, Nadiya Orel, Anzhela Kyryk, and Holger Puchta -- Analysis of recombinational repair of DNA double-strand breaks in mammalian cells with I-SceI nuclease / Jac A. Nickoloff and Mark A. Brenneman -- Transformation of monomorphic and pleomorphic Trypanosoma brucei / Richard McCulloch, Erik Vassella, Peter Burton, Michael Boshart, and J. David Barry -- Forward genetic screens for meiotic and mitotic recombination-defective mutants in mice / Laura Reinholdt, Terry Ashley, John Schimenti, and Naoko Shima -- Detecting carcinogens with the yeast DEL assay / Richard J. Brennan and Robert H. Schiestl --In vivo DNA deletion assay to detect environmental and genetic predisposition to cancer / Ramune Reliene, Alexander J. R. Bishop, Jiri Aubrecht, and Robert H. Schiestl -- Gene targeting at the chromosomal immunoglobulin locus: a model system for the study of mammalian homologous recombination mechanisms / Mark D. Baker -- DNA fragment transplacement in Saccharomyces cerevisiae: some genetic considerations / Glenn M. Manthey, Michelle S. Navarro, and Adam M. Bailis -- Targeted gene modification using triplex-forming oligonucleotides / Jean Y. Kuan and Peter M. Glazer -- Using nucleases to stimulate homologous recombination / Dana Carroll -- Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA / Katie K. Maguire and Eric B. Kmiec -- The use of the chromatin immunoprecipitation to investigate protein-DNA interactions during recombination / Tamara Goldfarb and Eric Alani -- Holliday junction branch migration and resolution assays / Angelos Constantinou and Stephen C. West.

The master elements of control -- Protein-DNA interactions and gene control -- Control circuits: setting the switch -- How do we know: the key experiments -- Guide.

Classification of periodontal diseases -- Evidence for the role of genetic variants in periodontitis -- A gene mutation of major effect on human disease and its association with periodontitis -- Modifying disease genes in relation to periodontitis -- Heritability of chronic periodontitis -- Heritability of aggressive periodontitis -- Heritability of gingivitis -- Heritability of peri-implantitis -- Common guidelines for association studies -- Clinical utility of genetic knowledge.

Part 1.Application and Perspectives --ch. 1.Transgenic Modification of Production Traits in Farm Animals /Mathias Müller and Gottfried Brem --ch. 2.Genetically Modified Plants /Susanne Stirn and Horst Lörz --ch. 3.Fermented Food Production using Genetically Modified Yeast and Filamentous Fungi /Anke Niederhaus and Ulf Stahl --ch. 4.Production of Food Additives using Filamentous Fungi /Carsten M. Hjort --ch. 5.Perspectives of Genetic Engineering of Bacteria used in Food Fermentations /Arnold Geis --Part II.Legislation in Europe --ch. 6.The Legal Situation for Genetically Engineered Food in Europe /Rudolf Streinz and Lars O. Fuchs --Part III.Methods of Detection --ch. 7.Detection of Genetic Modifications: Some Basic Considerations /Knut J. Heller --ch. 8.DNA-based Methods for Detection of Genetic Modifications /Ralf Einspanier and Stephanie Rief --ch. 9.Genetic Engineering of Fishes and Methods for Detection /Hartmut Rehbein --ch. 10.Detection Methods for Genetically Modified Crops /Rolf Meyer --ch. 11.Methods to Detect the Application of Genetic Engineering in Composed and Processed Foods /Karl-Heinz Engel and Francisco Moreano --ch. 12.Mutations in Lactococcus lactis, and their Detection /Jan Kok and Bertus van den Burg --ch. 13.Detection Methods for Genetically Modified Microorganisms used in Food Fermentation /Walter P. Hammes, Christian Hertel and Torsten Bauer.

Part I. Application and Perspectives -- ch. 1. Transgenic modification of production traits in farm animals / Gottfried Brem, Mathias Müller -- ch. 2. Genetically modified plants / Susanne Stirn, Horst Lörz -- ch. 3. Fermentation of food by means of genetically modified yeast and filamentous fungi / Rena Leisegang, Elke Nevoigt, Anja Spielvogel, Georg Kristan, Anke Niederhaus, Ulf Stahl -- ch. 4. Production of food additives using filamentous fungi / Carsten M. Hjort -- ch. 5. Genetic engineering of bacteria used in food fermentation / Arnold Geis -- Part II. Legislation in Europe -- ch. 6. The Legal situation for genetically engineered food in Europe / Rudolf Streinz, Jan Kalbheim -- Part III. Methods of Detection -- ch. 7. Detection of genetic modifications : some basic considerations / Knut J. Heller -- ch. 8. DNA-based methods for detection of genetic modifications / Ralf Einspanier -- ch. 9. Genetic engineering of fish, and methods of detection / Hartmut Rehbein -- ch. 10. Detection methods for genetically modified crops / Rolf Meyer -- ch. 11. Methods for detection of genetically modified organisms in composite and processed foods / Karl-Heinz Engel, Francisco Moreano, Alexandra Ehlert -- ch. 12. Mutations in Lactococcus lactis and their detection / Jan Kok, Bertus van den Burg -- ch. 13. Methods for detection of genetically modified microorganisms used in food fermentation processes / Walter P. Hammes, Christian Hertel, Torsten Bauer.

1. The 26-Nation Survey -- 2. Global inequity -- 3. The rise of autonomy -- 4. Counseling: directive and nondirective -- 5. Is modern genetics eugenics? -- 6. Genetics as a family affair -- 7. Privacy, discrimination, and public health -- 8. The geography of ethical reasoning -- 9. Geneticists speak out: culture, ethics, and history -- 10. Organization of genetic services -- 11. Laws affecting genetic services -- 12. China: views of a bioethicist -- 13. China: views of a geneticist -- 14. Germany -- 15. Hungarian TV viewers' responses -- 16. India -- 17. Japan -- 18. Peru -- 19. From genetics to genomics and beyond -- 20. Moral priorities, cases and practices in medical genetics.

Limits and uncertainty in nature and logic -- Quantum fluctuations, mutations, and "fixation" of uncertainty -- Recombination and randomness -- Uncertainty of development -- Organized randomness -- Random genetic drift and "deterministic" selection -- Life : making uncertainty certain.

Key concepts in human genetics : understanding the complex phenotype / W.T. Gibson -- Nature versus nurture in determining athletic ability / T.D. Brutsaert, E.J. Parra -- Genetics and sports : an overview of the pre-molecular biology era / M.W. Peeters ... [et al.] -- Genes, athlete status, and training : an overview / I.I. Ahmetov, V.A. Rogozkin -- Angiotensin : converting enzyme, renin-angiotensin system and human performance / D. Woods -- Actinin-3 and performance / N. yang, F. Garton, K. North -- East African runners : their genetics, lifestyle, and athletic prowess / V.O. Onywera -- Gene-lifestyle interactions and their consequences on human health / J. Pomeroy, A.M. Söderberg, P.W. Franks -- Genetic risk factors for musculoskeletal soft tissue injuries / M. Collins, S.M. Raleigh -- Innovative strategies for treatment of soft tissue injuries in human and animal athletes / A. Hoffmann, G. Gross -- Gene doping : possibilities and practicalities / D.J. Wells -- Genetic testing of athletes / A.G. Williams, H. Wackerhage -- The future of genetic research in exercise science and sports medicine / R.J. Trent, B. Yu.

Who am I? Genes and the problem of historical identity /Keith Wailoo --Reconciliation projects : from kinship to justice /Alondra Nelson --The unspoken significance of gender in constructing kinship, race, and nation /Catherine Lee --A biologist's perspective on DNA and race in the genomics era /Abram Gabriel --The dilemma of classification : the past in the present /Lundy Braun and Evelynn Hammonds --The informationalization of race : communication, databases, and the digital coding of the genome /Peter A. Chow-White --Forensic DNA phenotyping : continuity and change in the history of race, genetics, and policing /Pamela Sankar --Forensic DNA and the inertial power of race in American legal practice /Jonathan Kahn --Making history via DNA, making DNA from history : deconstructing the race-disease connection in admixture mapping /Ramya Rajagopalan and Joan H. Fujimura --Waiting on the promise of prescribing precision : race in the era of pharmacogenomics /Sandra Soo-Jin Lee --French families, paper facts : genetics, nation, and explanation /Nina Kohli-Laven --Categorization, census, and multiculturalism : molecular politics and the material of nation /Amy Hinterberger --"It's a living history, told by the real survivors of the times-DNA" : anthropological genetics in the tradition of biology as applied history /Marianne Sommer --Cells, gene, and stories : HeLa's journey from labs to literature /Priscilla Wald --The case of the genetic ancestor /Jennifer A. Hamilton --Making sense of genetics, culture, and history : a case study of a native youth education program /Michelle M. Jacob --Humanitarian DNA identification in post-apartheid South Africa /Jay D. Aronson --Forbidden or forsaken? The (mis)use of a forbidden knowledge argument in research on race, DNA, and disease /Reanne Frank --Genetic claims and credibility : revisiting history and remaking race /Keith Wailoo, Catherine Lee, and Alondra Nelson.

A glimpse into genomeland /Langenbeck, U. --Epidemiology of hereditary ocular disorders /Rosenberg, T. --Interactions of genes and environment in myopia /Feldkämper, M., Schaeffel, F. --A molecular perspective on corneal dystrophies /Vincent, A.L., Rootman, D., Munier, F.L., Héon, E. --Molecular genetics of cataract /Hejtmancik, J.F., Smaoui, N. --Progress in the genetics of glaucoma /Weisschuh, N., Schiefer U. --LHON and other optic nerve atrophies: the mitochondrial connection /Howell, N. --Retinitis pigmentosa: genes, proteins and prospects /Hims, M.M., Diager, S.P., Inglehearn, C.F. --Bardet-Biedl syndrome and Usher syndrome /Koenig, R. --Genetic defects in vitamin A metabolism of the retinal pigment epithelium /Thompson, D.A., Gal, A. --Genetics of macular dystrophies and implications for age-related macular degeneration /Klaver, C.C.W., Allikmets, R. --Genetics of color vision deficiencies /Deeb, S.S., Kohl, S. --Gene therapy and animal models for retinal disease /Dejneka, N.S., Rex, T.S., Bennett, J. --Support for patients loosing [sic] sight /Trauzettel-Klosinski, S., Hahn, G.0A. -Author index --Subject index.

The genetics of male infertility in the era of genomics: tools for progress / Douglas T. Carrell -- The use of cDNA libraries to demonstrate a linkage between transcription and translation in male germ cells / Norman B. Hecht -- Considerations when using array technologies for male factor assessment / Adrian E Platts, David J. Dix, and Stephen A. Krawetz -- Microarray analysis of a large number of single-nucleotide polymorphisms in individual human spermatozoa / Honghua Li ... [et al.] -- Physiological and proteomic approaches to understand human sperm function: prefertilization events / Sarah J. Conner -- Genetics of idiopathic male infertility: the power of a cross-species approach / Angshumoy Roy, Yi-Nan Lin, and Martin M. Matzuk -- The immunocytogenetics of human male meiosis: a progress report / Daniel Topping, Petrice Brown, and Terry Hassold -- The clinical relevance of sperm aneuploidy / Renee H. Martin -- DNA repair genes and genomic instability in severe male factor infertility / Francesca K.E. Gordon and Dolores J. Lamb -- Germ cell-specific genes and posttranscriptional regulation in the testis / Mark S. Fox and Renee A. Reijo Pera -- The genetics of cryptorchidism / Alexander I. Agoulnik and Shu Feng -- The chromatoid body and microRNA pathways in male germ cells / Martti Parvinen ... [et al.] -- Sperm maturation in the epididymis: role of segment-specific microenvironments / Gail A. Cornwall and Hans H. von Horsten --The structure of the Y chromosome in infertility / Leslie Ayensu-Coker, Collin Bishop, and Jan Rohozinski -- Y chromosome microdeletions and haplotypes / Ken McElreavey ... [et al.] -- The genetics of male infertility: from bench to clinic / David M. de Kretser ... [et al.] -- The future of the diagnosis of male (in)fertility / Christopher De Jonge -- Polymorphisms and male infertility / Csilla Krausz -- The genetics of abnormal protamine expression / Vincent W. Aoki and Douglas T. Carrell -- Chromatin damage and male infertility / Denny Sakkas, Davide Bizzaro, and Gian C. Manicardi -- Clinical evaluation of the genetics of male infertility / Peter N. Schlegel.

Genetics: the study of biological information -- Mendel's breakthrough: patterns, particles, and principles of heredity -- Extensions to mendel: complexities in relating genotype to phenotype -- The chromosome theory of inheritance -- Linkage, recombination, and the the mapping of genes on chromosomes -- DNA: how the molecule of heredity carries, replicates, and recombines information -- Anatomy and function of a gene: dissection through mutation -- Gene expression: the flow of genetic information from DNA to RNA to protein -- Deconstructing the genome: DNA at high resolution -- Reconstructing the genome through genetic and molecular analysis -- The direct detection of genotype distinguishes individual genomes -- Systems biology and proteomics -- The eukaryotic chromosome: an organelle for packaging and managing DNA -- Chromosomal rearrangements and changes in chromosome number reshape eukaryotic genomes -- The prokaryotic chromosome: genetic analysis in bacteria -- The chromosomes of organelles outside the nucleus exhibit non-mendelian patterns of inheritance -- Gene regulation in prokaryotes -- Gene regulation in eukaryotes -- Cell-cycle regulation and the genetics of cancer -- Using genetics to study development -- The genetic analysis of populations and how they evolve -- Evolution at the molecular level.

Genes, genomes, and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- Chromosomes and sex-chromosome inheritance -- Genetic linkage and chromosome mapping -- Molecular biology of DNA replication and recombination -- Molecular organization of chromosomes -- Human karyotypes and chromosome behavior -- Genetics of bacteria and their viruses -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Genomics, proteomics, and transgenics -- Genetic control of development -- Molecular mechanisms of mutation and DNA repair -- Molecular genetics of the cell cycle and cancer -- Mitochondrial DNA and extranuclear inheritance -- Molecular evolution and population genetics -- The genetic basis of complex traits.

Disorders of cornification -- Disorders of pigmentation -- Disorders of vascularization -- Disorders of connective tissue -- Disorders with malignant potential -- Epidermolysis bullosa -- Disorders of porphyrin metabolism -- Disorders with photosensitivity -- Disorders with immunodeficiency -- Disorders of hair and nails -- Disorders of metabolism -- Disorders with chromosome abnormalities -- Disorders with short stature.

The genomic basis of disease, mechanisms and assays for genomic disorders / P. Stankiewicz, J.R. Lupski -- Gross deletions and translocations in human genetic disease / S.S. Abeysinghe, N. Chuzhanova, D.N. Cooper -- Nucleotide excision repair and related human diseases / V. Bergoglio, T. Magnaldo -- Oxidative damage to DNA in non-malignant disease / M.D. Evans, M.S. Cooke -- Dominant non-coding repeat expansions in human disease / K.A. Dick ... [et al.] -- Telomeres and telomerase in stem cells during aging and disease / Z. Ju, K.L. Rudolph -- Retrotransposable elements and human disease / P.A. Callinan, M.A. Batzer -- The spindle checkpoint and chromosomal stability / W. Qi, H. Yu -- Protein kinases that regulate chromosome stability and their downstream targets / H. Nojima -- The role of the APC tumor suppressor in chromosomal instability / P. Alberici, R. Fodde -- c-Myc, genomic instability, and disease -- F. Kuttler, S. Mai -- Nijmegen breakage syndrome and functions of the responsible protein, NBS1 / A. Antoccia ... [et al.] -- Werner syndrome, aging, and cancer / A. Ozgenc, L.A. Loeb -- Fanconi anemia / R. Kalb ... [et al.].

Honeybee / D. Schlipalius, P.R. Ebert, G.J. Hunt -- Bumblebee / L. Wilfert, P. Schmid-Hempel, J. Gadau -- The jewel wasp - Nasonia / J. Gadau ... [et al.] -- Silkworm / Y. Yasukochi, H. Fujii, M.R. Goldsmith -- Pea aphid / J.A. Brisson, G.K. Davis -- Mosquito / D.W. Severson -- Hessian fly / J.J. Stuart, M.-S. Chen, M.O. Harris -- Tick / A.J. Ullmann, J.J. Stuart, C.A. Hill.

Human genome sequence -- Human genetic variation -- Genome structure and evolution -- Genomics of non-human species -- Bioinformatics and annotation -- Comparing genomes -- Comparative functional genomics -- Genetic variation and disease -- Genome biology and disease -- Human evolution.

Coming full circle: Cyclin-dependent kinases as anti-cancer drug targets / R.P. Fisher -- Core and linker histone modifications involved in the DNA damage response / J.E. Chubb and S. Rea -- Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56 / T. Costelloe and N.F. Lowndes -- Structure and function of histone H2AX / D.M. Pinto and A. Flaus -- The initiation step of eukaryotic DNA replication / H. Pospiech, F. Grosse and F.M. Pisani -- Non-coding RNAs: New players in the field of eukaryotic DNA replication / T. Krude -- Function of TopBP1 in Genome Stability / M. Sokka ... [et al.] -- Eukaryotic single-stranded DNA binding proteins: central factors in genome stability / S. Broderick ... [et al.] -- DNA polymerases and mutagenesis in human cancers / E. Crespan, A. Amoroso and G. Maga -- DNA polymerase [eta], a key protein in translesion synthesis in human cells / S. Cruet-Hennequart ... [et al.] -- The mitochondrial DNA polymerase in health and disease / W.C. Copeland -- Centromeres: assembling and propagating epigenetic function / M. Glynn ... [et al.] -- Nucleotide excision repair in higher eukaryotes: mechanism of primary damage recognition in global genome repair / N.I. Rechkunova and O.I. Lavrik -- Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans / M.R. Lieber ... [et al.] -- Fluorescence-based quantification of pathway-specific DNA double-strand break repair activities: a powerful method for the analysis of genome destabilizing mechanisms / M. Bohringer and L. Wiesmuller -- Apoptosis: a way to maintain healthy individuals / C. Mondello and A.I. Scovassi -- The use of transgenic mice in cancer and genome stability research / S. Conmy and H.P. Nasheuer.

Genomes, transcriptomes, and proteomes -- Studying DNA -- Mapping genomes -- Sequencing genomes -- Understanding a genome sequence -- Understanding how a genome functions -- Eukaryotic nuclear genomes -- Genomes of prokaryotes and eukaryotic organelles -- Virus genomes and mobile genetic elements -- Accessing the genome -- Assembly of the transcription initiation comple -- Synthesis and processing of RNA -- Synthesis and processing of the proteome -- Regulation of genome activity -- Genome replication -- Mutations and DNA repair -- Recombination -- How genomes evolve -- Molecular phylogenetics.

v. 1. Principles, methodology, and translational approaches -- v. 2. Genome discoveries and clinical applications.

"Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].

The CMT1A duplication: a historical perspective viewed from two sides of an ocean / James R. Lupski and Vincent Timmerman -- Alu elements / Prescott Deininger -- The impact of LINE-1 retrotransposition on the human genome / Amy E. Hulme ... [et al.] -- Ancient transposable elements, processed pseudogenes, and endogenous retroviruses / Adam Pavlicek and Jerzy Jurka -- Segmental duplications / Andrew J. Sharp and Evan E. Eichler -- Non-B DNA and chromosomal rearrangements / Albino Bacolla and Robert D. Wells -- Genetic basis of olfactory deficits / Idan Menashe, Ester Feldmesser, and Doron Lancet -- Genomic organization and function of human centromeres / Huntington F. Willard and M. Katharine Rudd -- Primate chromosome evolution / Stefan Müller -- Genome plasticity in evolution: the centromere repositioning / Mariano Rocchi and Nicoletta Archidiacono --The CMT1A duplication and HNPP deletion / Vincent Timmerman and James R. Lupski -- Smith-Magenis syndrome deletion, reciprocal duplication dup(17)(p11.2p11.2), and other proximal 17p rearrangements / Paweł Stankiewicz, Weimin Bi, and James R. Lupski -- Chromosome 22q11.2 rearrangement disorders / Bernice E. Morrow -- Neurofibromatosis 1 / Karen Stephens -- Williams-Beuren syndrome / Stephen W. Scherer and Lucy R. Osborne -- Sotos syndrome / Naohiro Kurotaki and Naomichi Matsumoto -- X chromosome rearrangements / Pauline H. Yen -- Pelizaeus-Merzbacher disease and spastic paraplegia type 2 / Ken Inoue -- Y-chromosomal rearrangements and azoospermia / Matthew E. Hurles and Chris Tyler-Smith --Inversion chromosomes / Orsetta Zuffardi ... [et al.] -- Monosomy 1p36 as a model for the molecular basis of terminal deletions / Blake C. Ballif and Lisa G. Shaffer -- Inv dup(15) and inv dup(22) / Heather E. McDermid and Rachel Wevrick -- Mechanisms underlying neoplasia-associated genomic rearrangements / Thoas Fioretos -- Recombination hotspots in nonallelic homologous recombination / Matthew E. Hurles and James R. Lupski -- Position effects / Paweł Stankiewicz -- Chromosome-engineered mouse models / Pentao Liu -- Array-CGH for the analysis of constitutional genomic rearrangements / Nigel P. Carter ... [et al.] -- Appendix A: Well-characterized rearrangement-based diseases and genome structural features at the locus / Paweł Stankiewicz and James R. Lupski -- Appendix B: Diagnostic potential for chromosome microarray analysis / Paweł Stankiewicz, Sau W. Cheung and Arthur L. Beaudet.

Generation of monoparental embryos for investigation into genomic imprinting -- Deriving and propagating mouse embryonic stem cell lines for studying genomic imprinting -- Balanced translocation for the analysis of imprinted regions of the mouse genome -- Production of YAC transgenic mice by pronuclear injection -- A transgenic approach to studying imprinted genes: modified BACs and PACs -- Methylation-sensitive genome scanning -- Subtraction-hybridization method for the identification of imprinted genes -- Identification of imprinted loci by methylation: use of methylation-sensitive representational difference analys (Me-RDA) -- Ribonuclease protection -- Quantitative RT-PCR-based analysis of allele-specific gene expression --Allele-specific In Situ hybridization (ASISH) -- RNA-FISH to analyze allele-specific expression -- Flow cytometry and FISH to investigate allele-specific replication timing and homologous association of imprinted chromosomes -- Southern analysis using methyl-sensitive restriction enzymes -- A PCR-based method for studying DNA methylation -- Bisulfite-based methylation analysis of imprinted genes -- Direct analysis of chromosome methylation -- In vitro methylation of predetermined regions in recombinant DNA constructs -- In vitro methylation of specific regions in recombinant DNA constructs by excision and religation -- Probing chromatin, structure with nuclease sensitivity assays --Examining histone acetylation at specific genomic regions -- Purification of the MeCP2/histone deacetylase complex from Xenopus laevis -- Reconstitution of chromatin in vitro -- Genomic imprinting in plants.

DNA methylation reprogramming in the germ line / Diane J. Lees-Murdock and Colum P. Walsh -- Control of imprinting at the GNAS cluster / Jo Peters and Christine M. Williamson -- The GNAS locus and pseudohypoparathyroidism / Murat Bastepe -- Imprinted genes, postnatal adaptations, and enduring effects on energy homeostasis / Margalida Frontera ... [et al.] -- What are imprinted genes doing in the brain? / William Davies ... [et al.] --Genomic imprinting and human psychology : cognition, behavior, and pathology / Lisa M. Goos and Gillian Ragsdale -- Genomic imprinting in plants / Olivier Garnier, Sylvia Laouiellé-Duprat, and Charles Spillane -- Imprinted genes and human disease : an evolutionary perspective / Francisco Úbeda and Jon F. Wilkins -- Evolutionary theories of imprinting ; enough already! / Tom Moore and Walter Mills.

Making the genome public : the American Museum of Natural History and the coming age of genomics / Michael Yudell and Rob DeSalle -- Genome science and the new frontier -- Introduction / Nicholas Wade -- What does knowing about genomes mean for science and society? / Harold Varmus -- Sequencing the human genome : elucidating our genetic blueprint / Eric Green -- Whole-genome shotgun sequencing / J. Craig Venter -- After the genome: where should we go? / Leroy Hood -- Applications of genomics to medicine and agriculture -- Introduction / Robert Bazell -- Genomics : a rapid road from gene to patient / William Haseltine -- The origins of cancer and the human genome / Arnold J. Levine -- Gene diversity in the endorphin system: SNPs, chips, and possible implications / Mary Jeanne Kreek -- Genomics and biotechnology in agriculture / Barbara A. Schaal -- Exploring human variation : understanding identity in the genomic era -- Introduction / Rob DeSalle -- Using maternal and paternal genes to unlock human history / Douglas C. Wallace -- Eugenics, the genome, and human rights / Daniel J. Kevles -- Redesigning the self: the promise and perils of genetic enhancement / David J. Rothman and Sheila M. Rothman -- Financial, legal, and ethical issues and the new genomics -- Introduction / Michael Waldholz -- Investing in the biotechnology sector / Kris H. Jenner -- The role of patents in exploiting the genome / Rebecca Eisenberg -- Social side effects of the new human molecular genetic diagnostics / Troy Duster -- Mapping morality : the rights and wrongs of genomics / Arthur l. Caplan -- Summing up : finding our way through the revolution / Kathi E. Hanna.

From genes to genomes: a historical perspective -- The human genome: structure and organization -- Human function genomics and proteomics -- Epigenomics and human disease -- Genomic perspectives of human development -- Genetic and genomic approaches to taxonomy of human disease -- Genomic technologies -- Nutritional genomics -- Pharmacogenomics: drug development, drug response, and precision medicines -- Clinical medicine in the genome era: an introduction -- Complex cardiovascular disorders -- Diabetes mellitus and obesity -- Chronic renal disease -- Hemostasis and thrombosis -- Disorders of platelets -- Applications in critical care medicine -- The epilepsies -- Neurodegenerative disorders: tauopathies and synucleinopathies -- Neuropsychiatric diseases I: schizophrenia -- Neuropsychiatric disease II: mood disorders -- Asthma and chronic obstructive pulmonary disease -- Inflammatory bowel disease -- Genomics and cancer: mechanisms and applications -- Hematological malignancies: the paradigm of acute myeloid leukemia -- Genomics and infectious diseases: susceptibility, resistance, antimicrobial therapy -- Rheumatoid arthritis and related arthropathies -- Immunological disorders -- Applications in clinical pediatrics -- Learning and behavioral disorders -- Complex ophthalmic disorders -- Applications in audiological medicine -- Complex skin diseases I: psoriasis -- Complex skin diseases II: atopic dermatitis -- Diseases of the epidermis and appendages, skin pigmentation and skin cancer -- Osteoporosis and disorders -- Applications in obstetrics and gynecology and reproductive medicine -- Stem cell genomics, and regenerative medicine -- Genomics and global health -- Genetic testing and genomic screening -- Ethical, legal, and social issues (ELSI) -- The regulation of human genomics research.

Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.

Part I: Mouse models of human diseases and gene transcription. 1. Genetic modifiers in rodent models of obesity / Yun Wang, Patsy M. Nishina, and Jurgen K. Naggert -- 2. Quantitative trait loci in obesity and type II diabetes in rodents / Jung Han Kim -- 3. The human sweet tooth and its relationship to obesity / Amanda H. McDaniel and Danielle R. Reed -- 4. The adipose renin-angiotensin system: genetics, regulation, and physiologic function / Brynn H. Voy ... [et al.] -- 5. Regulation of fat synthesis and adipogenesis / Kee-Hong Kim ... [et al.] -- 6. Transcriptional regulation of energy metabolism in liver / Manabu T. Nakamura. Part II: Genomics: large-scale analysis of gene expression by microarray. 7. Design and analysis of microarray studies for obesity research / Marie-Pierre St.-Onge ... [et al.] -- 8. Solving clinical problems in nutrition research with microarrays / Steven R. Smith ... [et al.] -- 9. Genomic approaches to understanding vitamin D action / James C. Fleet -- 10. Gene expression profiling in adipose tissue / Naima Moustaid-Moussa ... [et al.] -- 11. Phytochemicals and gene expression / Orsolya Mezei and Neil F. Shay --12. Gene expression profiling of immune cells: application for understanding aging of immune cells / Sung Nim Han and Simin Nikbin Meydani -- 13. Improving the nutritional value of cereal grains using a genomic approach / Liang Shi and Tong Zhu. Part III: Proteomics: large-scale analysis of protein expression and regulation. 14. Proteomics and genomics to detail responses to extracellular stimuli / James A. Carroll and Clayton E. Mathews -- 15. 2D gel proteomics studies on leukocytes / Ivan C. Gerling and Michael J. Pabst -- 16. Proteomics: tools for nutrition research in the postgenomic era / Arthur Grider -- 17. Proteomic analysis of the adipocyte secretome / Nieves Ibarrola, Akhilesh Pandey, and Chaerkady Raghothama -- 18. Mass spectrometry strategies for proteomic studies / Maya Belghazi and Helene Rogniaux -- Bioinformatics tools / Simon M. Lin, Kimberly F. Johnson, and Seth W. Kullman -- 20. Statistical principles for analysis of array experiments / Arnold M. Saxton and E. Barry Moser.

Microarray-based gene expression analysis of endocrine systems: principles of experimental design and interpretation. -- Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblastic cells. -- Analysis of growth hormone effects on hepatic gene expression in hypophysectomized rats. -- Gene expression profiling in leiomyoma in response to GnRH therapy and TGF-beta. -- Gene profiling analysis of androgen receptor mediated function. -- Interrogating estrogen receptor [alpha] signaling in breast cancer by chromatin immunoprecipitation microarrays. -- Gene expression analysis of the adrenal cortex in health and disease. -- DNA microarray analysis of human uterine decidualization. -- Large-scale DNA microarray data analysis reveals glucocorticoid receptor-mediated breast cancer cell survival pathways. -- Application of microarrays for gene transcript analysis in type 2 diabetes. -- DNA microarray analysis of effects of TSH, iodide, cytokines, and therapeutic agents on gene expression in cultured human thyroid follicles. -- Genomics and polycystic ovary syndrome (PCOS): the use of microarray analysis to identify new candidate genes. -- Microarray analysis of alterations induced by obesity in white adipose tissue gene expression profiling. -- Novel molecular signaling and classification of human clinically nonfunctioning pituitary adenomas identified by microarray and reverse transcription-quantitative polymerase chain reaction. -- Gene expression studies of prostate hyperplasia in prolactin transgenic mice.

Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].

Protein profiling based on two-dimensional difference gel electrophoresis / Gert Van den Bergh and Lutgarde Arckens -- Quantitative protein profiling by mass spectrometry using isotope-coded affinity tags / Arsalan S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Quantitative protein profiling by mass spectrometry using label-free proteomics / Arsala S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Using 2D-LC-MS/MS to identify Francisella tularensis peptides in extracts from an infected mouse macrophage cell line / John F. Kelly and Wen Ding -- Baculovirus expression vector system : an emerging host for high-throughput eukaryotic protein expression / Binesh Shrestha, Carol Smee, and Opher Gileadi -- Coimmunoprecipitation and proteomic analyses / S. Fabio Falsone, Bernd Gesslbauer, and Andreas J. Kungl -- Tandem affinity purification combined with mass spectrometry to identify components of protein complexes / Peter Kaiser ... [et al.] -- Mammalian two-hybrid assay for detecting protein-protein interactioins in vivo / Runtao He and Xuguang Li -- Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation / Victor Villalobos, Snehal Naik, and David Piwnica-Worms -- Subcellular localization of intracellular human proteins by construction of tagged fusion proteins and transient expression in COS-7 cells / John E. Collins -- GeneFAS : a tool for the prediction of gene function using multiple sources of data / Trupti Joshi ... [et al.] --Comparative genomics-based prediction of protein function / Toni Gabaldón -- Design, manufacture, and assay of the efficacy of siRNAs for gene silencing / Louise A. Dawson and Badar A. Usmani.Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield / Kaisa Silander and Janna Saarela -- Scanning for DNA variants by denaturant capillary electrophoresis / Per O. Ekstrøm -- Identification of SNPs, or mutations in sequence chromatograms / Nicole Draper -- BeadArray-based genotyping / Helen Butler and Jiannis Ragoussis -- Microsattelite-based candidate gene linkage analysis studies / Cathryn Mellersh -- Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH) / Alexei Protopopov, Bin Feng, and Lynda Chin -- Detection of copy number changes at multiple loci in DNA prepared from formalin-fixed, paraffin-embedded tissue by multiplex ligation -dependent probe amplification / Minoru Takata -- Application of microarrays for DNA methylation profiling / Axel Schumacher, Andreas Weinhäusl, and Arturas Petronis -- Genomewide identification of protein binding locations using chromatin immunoprecipitation coupled with microarray / Byung-Kwan Cho, Eric M. Knight, and Bernhard Ø. Palsson -- Transcriptional profiling of small samples in the central nervous system / Stephen D. Ginsberg -- Quantitative expression profiling of RNA from formalin-fixed, paraffin-embedded tissues using randomly assembled bead arrays / Marina Bibikova ... [et al.] -- Expression profiling of microRNAs in cancer cells : technical considerations / Mouldy Sioud and Lina Cekaite -- Identification of disease biomarkers by profiling of serum proteins using SELDI-TOF mass spectrometry / Sigrun Langbein -- The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease / Peter Ellmark ... [et al.] --

Comparative genome analyses of the pathogenic Yersiniae based on the genome sequence of Yersinia enterocolitica strain 8081 / N.R. Thomson ... [et al.] -- Pestoides F, an atypical Yersinia pestis strain from the former Soviet Union / E. Garcia ... [et al.] -- Variability of the protein sequences of lcrV between epidemic and atypical rhamnose-positive strains of Yersinia pestis / A.P. Anisimov ... [et al.] -- A new asset for pathogen informatics - the Enteropathogen Resource Integration Center (ERIC), an NIAID bioinformatics resource center for biodefense and emerging/re-emerging infectious disease / J.M. Greene ... [et al.] -- My life with Yersinia / M. Skurnik -- Structure and assembly of Yersinia pestis F1 antigen / S.D. Knight -- Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors / Y.A. Knirel ... [et al.] -- Characterization of six novel chaperone/usher systems in Yersinia pestis / S. Felek ... [et al.] -- Polyamines in bacteria : Pleiotropic effects yet specific mechanisms / B.W. Wortham ... [et al.] -- Intermediary metabolism, Na+, the low calcium-response, and acute disease / R.R. Brubaker -- Differential gene regulation in Yersinia pestis versus Yersinia pseudotuberculosis : Effects of hypoxia and potential role of a plasmid regulator / G. Bai ... [et al.] -- Two-component system regulon plasticity in bacteria : A concept emerging from phenotypic analysis of Yersinia pseudotuberculosis response regulator mutants / C. Flamez ... [et al.] -- Regulatory elements implicated in the environmental control of invasin expression in enteropathogenic Yersinia / A.K. Heroven ... [et al.] -- Regulation of the phage-shock-protein stress response in Yersinia enterocolitica / A.J. Darwin -- Functional quorum sensing systems affect biofilm formation and protein expression in Yersinia pestis / A.G. Bobrov ... [et al.] -- Analysis of Yersinia pestis gene expression in the flea vector / V. Vadyvaloo ... [et al.] -- Regulation of biofilm formation in Yersinia pestis / A.G. Bobrov ... [et al.] --Environmental stimuli affecting expression of the Ysa type three secretion locus / S. Mildiner-Earley ... [et al.] -- Polynucleotide phosphorylase and the T3SS / J.A. Rosenzweig ... [et al.] -- Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis / M.A. Hamad ... [et al.] -- Identification of TyeA residues required to interact with YopN and to regulate Yop secretion / S.S. Joseph ... [et al.] -- The insect toxin complex of Yersinia / N. Waterfield ... [et al.] -- Twin arginine translocation in Yersinia / M. Lavander ... [et al.] -- Using every trick in the book: The Pla surface protease of Yersinia pestis / M. Suomalainen ... [et al.] -- Invasion and dissemination of Yersinia enterocolitica in the mouse infection model / K. Trülzsch ... [et al.] -- The Ysa type 3 secretion system of Yersinia enterocolitica biovar 1B / G.M. Young -- A rationale for repression and/or loss of motility by pathogenic Yersinia in the mammalian host / S.A. Minnich ... [et al.] -- Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions / A. Zauberman ... [et al.] -- 3 IS-RFLP : A powerful tool for geographical clustering of global isolates of Yersinia pestis / A.J.L. Leclercq ... [et al.] -- Analysis of the three Yersinia pestis CRISPR loci provides new tools for phylogenetic studies and possibly for the investigation of ancient DNA / G. Vergnaud ... [et al.] -- Enrichment of Yersinia pestis from blood cultures enables rapid antimicrobial susceptibility determination by flow cytometry / I. Steinberger-Levy ... [et al.] -- Development and evaluation of a single tube nested PCR based approach (STNPCR) for the diagnosis of plague / G. Souza ... [et al.] -- Therapeutic potential of Yersinia anti-inflammatory components / B. Foligné ... [et al.] -- High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis / N. Pan ... [et al.] -- Cell-mediated defense against Yersinia pestis infection / S.T. Smiley --Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague / C.G. Branger ... [et al.] -- Yersinia pestis YadC: A novel vaccine candidate against plague / B.S. Murphy ... [et al.] -- Protective immunity against plague / C. Cornelius ... [et al.].

The practice of geriatric anesthesia / Jeffrey H. Silverstein -- Demographics and economics of geriatric patient care / Maria F. Galati and Roger D. London -- Theories of aging / Stanley Muravchick -- Ethical management of the elderly patient / Paul J. Hoehner -- Teaching geriatric anesthesiology to practitioners, residents, and medical students / Sheila J. Ellis -- Research priorities in geriatric anesthesiology / Christopher J. Jankowski and David J. Cook -- Alterations in metabolic functions and electrolytes / Michael C. Lewis -- Perioperative thermoregulation / Daniel I. Sessler -- Postoperative central nervous system dysfunction / Deborah J. Culley, Terri G. Monk, and Gregory Crosby-- Alterations in circulatory function / Thomas J. Ebert and G. Alec Rooke --The aging respiratory system : anesthetic strategies to minimize perioperative pulmonary complications / Rodrigo Cartin-Ceba ... [et al.] -- Operative debridements of chronic wounds / Andrew M. Hanflik ... [et al.] -- Preoperative risk stratificationand methods to reduce risk / Linda L. Liu and Jacqueline M. Leung -- Anesthetic implications of chronic medications / Tamas A. Szabo and R. David Warters -- The pharmacology of opioids / Steven L. Shafer and Pamela Flood -- Intravenous hypnotic anesthetics / Matthew D. McEvoy and J.G. Reves -- Inhalational anesthetics / Gary R. Haynes -- Relaxants and their reversal agents / Cynthia A. Lien and Takahiro Suzuki -- Management of regional anesthesia / Bernadette Veering --Fluid management / Jessica Miller, Lee A. Fleisher, and Jeffrey L. Carson -- Pain management / Jack M. Berger -- Anesthesia considerations for geriatric outpatients / Kathryn E. McGoldrick -- Sedaton and monitoring / Sheila R. Barnett -- Total hip replacement, joint replacement, and hip fracture / Idit Matot and Shaul Beyth -- Transurethral prostatectomy syndrome and other complications of urologic procedures / Daniel M. Gainsburg -- Thoracic procedures / Steven M. Neustein and James B. Eisenkraft -- Cardiac procedures / James H. Abernathy III -- Vascular procedures / Leanne Groban and Sylvia Y. Dolinski -- Abdominal procedures / Jeffrey H. Silverstein.

1. The aging society and nutrition epidemiology / Shailaja Pulisetty and John E. Morley -- 2. Molecular theories of aging and nutritional interventions / H.J. Armbrecht -- 3. The role of nutrition in the prevention of age-associated diseases / John E. Morley -- 4. Obesity in older adults / Gary A. Wittert -- 5. Sarcopenia and cachexia / John E. Morley and Matthew T. Haren -- 6. Immunity and nutrition / Chantri Trinh -- 7. Nutritional requirements in older adults / David R. Thomas -- 8. Energy balance / John E. Morley -- 9. Water metabolism / David R. Thomas and John E. Morley -- 10. Vitamin disorders / Ramzi R. Hajjar and Zeina Nahhas -- 11. Trace elements / John E. Morley -- 12. Nutritional assessment in older persons / David R. Thomas -- 13. Geriatric assessment and its interaction with nutrition / Julie K. Gammack -- 14. Nutritional assessment in the European community / Juergen Martin Bauer and Dorothee Volkert -- 15. The oral cavity and nutrition / Nathalia Garcia and D. Douglas Miley -- 16. Management of protein-energy undernutrition in older adults / David R. Thomas -- 17. Prescription for enteral nutrition / Zareen Syed and Syed H. Tariq.

Aging and cancer, what oncologists need to know / Arti Hurria, Lodovico Balducci -- Assessing the older cancer patient / Melissa Cohen, David Reuben, Arash Naeim -- Cancer screening in older adults / Louise C. Walter -- Physiological consequences of aging / Bindu Kanapuru, William B. Ershler -- Assessment and impact of comorbidity in older adults with cancer / Athanasios Karampeasiz, Martine Extermann -- Geriatric syndromes defined and explained for oncology practice / Miriam B. Rodin -- Family caregivers / Betty R. Ferrell, Polly Mazanec -- Surgical management of the older patient with cancer / David M. Heimann, M. Margaret Kemeny -- Chemotherapy for the older adult with cancer / Supriya Mohile, Nail Nagovskiy, Lodovico Balducci -- Radiation therapy in geriatric oncology / Sarah E. Hoffe, Mark S. Russell -- Palliative care, special considerations for older adults with cancer / Genevieve N. Thompson, Harvey M. Chochinov.

Scope of the problem and demographic shift in population: visual disease incidence and prevalence in the elderly population -- Refractive error in the geriatric population -- Cataracts and cataract surgery -- Glaucoma in the elderly -- Diabetic retinopathy and its management -- Age-related macular degeneration and its management -- Low vision: when vision fails -- Visual loss and depression -- Visual loss and dementia -- Visual loss and hearing loss -- Visual loss and falls -- Elder abuse -- Functional impairment and visual loss -- The research agenda-setting project (RASP) -- Screening for comorbidities -- Refer comorbidities.

Part 1. Aging and Comorbidity in Rheumatology -- The Immune System in Aging / Anjali Desai and Raymond L. Yung -- Bone Aging / Arthur N. Lau and Jonathan D. Adachi -- Atherosclerosis in the Rheumatic Diseases: Compounding the Age Risk / Naoto Yokogawa and Joan M. Von Feldt -- Neuropsychiatric Manifestations of Rheumatic Diseases in the Elderly / Jamal A. Mikdashi -- Tuberculosis and Rheumatoid Arthritis in the Elderly / Eduardo M. Acevedo-Vásquez, Darío Ponce de León and Rocío V. Gamboa-Cárdenas -- Widespread Pain in Older Adults / Cheryl D. Bernstein, Jordan F. Karp and Debra K. Weiner -- Part 2. Multidisciplinary Approach to Geriatric Rheumatology -- Pharmacotherapy Considerations Unique to the Older Patient / Keith A. Swanson and Mark A. Stratton -- Rheumatic Disease in the Nursing Home Patient / Joanne Sandberg-Cook -- Post-acute Care for Rheumatologists / Deborah W. Robin -- The Gerontorheumatology Outpatient Service: Toward an International Classification of Function-Based Health Care Provision for the Elderly with Musculoskeletal Conditions / Wim Van Lankveld, Josien Goossens and Marcel Franssen -- Health Policy, Public Health, and Arthritis Among Older Adults / Kristina A. Theis, Debra R. Lubar and Teresa J. Brady -- Physical Therapy Management of Select Rheumatic Conditions in Older Adults / Maura Daly Iversen and Madhuri K. Kale -- Arthrocentesis in the Elderly / Ahmed S. Zayat and Richard J. Wakefield -- Physical Activity in Older Adults with Arthritis / Dorothy D. Dunlop, Pamela A. Semanik and Rowland W. Chang --Part 3. Rheumatic Diseases in the Elderly -- Systemic Lupus Erythematosus in Elderly Populations / Ana M. Bertoli, Guillermo J. Pons-Estel, Paula I. Burgos and Graciela S. Alarcón -- Elderly Onset Rheumatoid Arthritis / Venkata Sri Cherukumilli and Arthur Kavanaugh -- Disease-Modifying Antirheumatic Drug Use in Older Rheumatoid Arthritis Patients / Sogol S. Amjadi, Veena K. Ranganath and Daniel E. Furst -- Epidemiology, Risk Factors, and Aging of Osteoarthritis / Crisostomo Bialog and Anthony M. Reginato -- Osteoarthritis in the Elderly Population / Roy D. Altman -- Medium- and Small-Vessel Vasculitis / Rafael G. Grau -- Management of Geriatric Gout / Lan X. Chen -- Calcium-Containing Crystal-Associated Arthropathies in the Elderly Population / Elisabeth B. Matson and Anthony M. Reginato -- Polymyalgia Rheumatica and Giant Cell Arteritis in the Elderly / Wolfgang A. Schmidt -- Antiphospholipid Syndrome in the Older Population / Silvia S. Pierangeli, Alan M. Seif and Emilio B. González -- Osteoporosis and Metabolic Bone Diseases of the Elderly / Lora Giangregorio and Alexandra Papaioannou -- Infectious Arthritis in the Elderly / Nicole Melendez and Luis R. Espinoza -- Sarcopenia and Myopathies in the Elderly / Kenneth S. O'Rourke -- Scleroderma in the Elderly Population / Rebecca L. Manno and Fredrick M. Wigley -- Sjögren's Syndrome in the Elderly / Raymond L. Yung and Sheeja Francis.

v. 1. Sperm and oocyte analysis -- v. 2. Molecular embryo analysis, live imaging, transgenesis, and cloning.

pt. I.Identification and regulation of germline stem cells in model organisms --The development of germline stem cells in Drosophila /David A. DansereauandPaul Lasko --Analysis of the C. elegans germline stem cell region /Sarah L. CrittendenandJudith Kimble --Immunohistological techniques for studying the Drosophila male germline stem cell /Shree Ram SinghandSteven X. Hou --Genetic tools used for cell lineage tracing and gene manipulation in Drosophila germline stem cells /Wei LiuandSteven X. Hou --Structural polarity and dynamics of male germline stem cells in an insect (milkweed bug Oncopeltus fasciatus) /David C. DornandAugust Dorn --High-resolution light microscopic characterization of spermatogonia /Hélio Chiarini-GarciaandMarvin L. Meistrich --Identification and characterization of spermatogonial subtypes and their expansion in whole mounts and tissue sections from primate testes /Jens EhmckeandStefan Schlatt --Epigenetic control in male germ cells : a transillumination-assisted microdissection method for the analysis of developmentally regulated events /Durga Prasad MishraandPaolo Sassone-Corsi --GDNF maintains mouse spermatogonial stem cells in vivo and in vitro /Hannu SariolaandTiina Immonen -- g pt. II. In vitro culture and application of germline stem cells --Ectopic grafting of mammalian testis tissue into mouse hosts /Ina DobrinskiandRahul Rathi --Spermatogonial stem cell transplantation, testicular function, and restoration of male fertility in mice /Derek J. McLean --Isolating highly pure rat spermatogonial stem cells in culture /F. Kent Hamra... [et al.] --Deriving mouse spermatogonial stem cell lines /Ilaria Falciatori... [et al.] --Production of knockdown rats by lentiviral transduction of embryos with short hairpin RNA transgenes /Christina Tenenhaus DannandDavid L. Garbers --Testicular germ cell tumors in mice : new ways to study a genetically complex trait /Jason D. HeaneyandJoseph H. Nadeau --Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries /Antonin Bukovsky... [et al.].

Policies and Reimbursement: Meeting the Need for Mental Health Care in Long-Term Care / Margaret Norris -- Referrals / Michael Smith -- Assessment / Barry A. Edelstein, Lynn E. Northrop and Lisa M. MacDonald -- Treatment Plans / Deborah W. Frazer -- Treatment Process / Michael Duffy -- Integration of Psychology, Psychiatry, and Medication in Long-Term Care / Lee Hyer and Shalija Shah -- Professional Practice: Disciplines, Documentation, and Outcomes Measurement / Merla Arnold, John C. Colletti and Nicholas C. Stilwell -- Ethical Issues in Long-Term Care / Michele J. Karel.