Books

Part 1: General Otolaryngology -- Syndromes and eponyms -- Obstructive sleep apnea -- Laser and radiofrequency surgery-- Anesthesia for head and neck surgery -- Surgical hemostasis and clotting mechanisms -- Related neurology and neurosurgery -- The chest for ENT -- Nutrition, fluid, and electrolytes -- Antimicrobial therapy in otolaryngology--Head and neck surgery -- Parmacology and therapeutics -- Head and neck manifestations of HIV -- Granulomatous diseases of the head and neck -- Part 2: Otology/Neurotology/Audiology -- Anatomy of the ear -- Audiology -- Electrical response audiometry -- Vestibular and balance disorders -- Congential hearing loss -- Tinnitus -- Hearing rehabilitation: Surgical and nonsurgical -- Cochlear implants -- Facial nerve paralysis -- Infections of the temporal bone -- Noninfectious disorders of the ear -- Tumors of the temporal bone -- Endoscopic meddle ear surgery -- Part 3: Rhinology --Sinonasal development and anatomy -- Nasal function and the evaluation of taste/smell -- Acute rhinosinusitis -- Chronic rhinosinusitis -- Fungal Rhinosinusitis -- Diseases of the nasal cavity -- Tumors of the paranasal sinuses -- Endoscopic sinus surgery -- Endoscopic skull base surgery -- Part 4: Head and Neck -- Salivary gland diseases -- Anamony, physiology, and disorders of the oral cavity, pharynx, and esophagus -- Neck spaces and fascial planes -- Thyroid and parathyroid glands -- Cysts and tumors of the jaw -- Carotid body tumors and vascular anomalies -- TNM classification in otolaryngology--Head and neck surgery -- Malignant melanoma of the head and neck -- Tumors of the larynx -- Tumors of the oral cavity, pharynx, and esophagus -- The role of chemotherapy for head and neck cancer -- Radiation therapy for head and neck cancer -- Tumor biology of head and neck cancer -- Skull base surgery -- Part 5: Laryngology -- The larynx -- Part 6: Pediatrics -- Embryology of clefts and pouches -- Cleft lip and palate -- Pediatric otolaryngology -- Part 7: Facial plastic & reconstructive surgery -- Facial plastic and reconstructive surgery -- Reconstructive head and neck surgery -- Craniomaxillofacial trauma-- Orbital fractures -- ENT-Related ophthalmology -- Part 8: Allergy -- Immunology and allergy -- Part 9: Review -- Highlights and pearls.

K-taping in theory - the special elastic tape's properties, basic principles and effects -- fundamentals of k-tape application -- contraindications. K-taping in practice -- the four major application techniques (muscle, ligament, correction, lymph applications), each described in detail and illustrated with a clinical case -- 70 particularly common medical conditions, and their treatment using k-tape applications -- each technique illustrated in up to six full-color photos and anatomical drawings -- concise step-by-step instruction, covering the specifics of each medical condition, plus additional practical tips -- memo boxes, summarizing the main points to remember.

1. The K-Taping Method -- 2. The Four Application Techniques -- 3. Tape applications for specific indications.

"This book proffers a new conceptual framework of sex, gender, and sexual identity, presenting data that documents these identities as typical and extensive rather than exceptional. A Kaleidoscope of Identities reveals the more elusive elements of sex, gender, and sexual life which are often difficult to capture in quantifiable variables"-- Provided by publisher.

"Now in brilliant full color throughout, Kandarpa's Handbook of Interventional Radiologic Procedures, 6th Edition, is a convenient, easy-access guide to all current radiologic procedures. Focusing on time-tested protocols, tailored imaging and current procedural equipment, this popular, practical handbook by Drs. Krishna Kandarpa, Lindsay Machan, Robert Lewandoski, and Parag J. Patel features extensive updates to keep you current with rapid growth in the field. It's an ideal resource not only for practicing interventional and general radiologists, but also for fellows and residents in training, IR nurses, and special procedure technologists. Covers indications, contraindications, preparation, technique, postprocedural management, prevention, and management of complications for every procedure. Includes expanded information on innovative oncological & lymphatic interventions. Features an all-new full-color design and illustrations, and an outline format for quick reference. Provides must-know information on vascular access and catheter-directed angiography, vascular imaging, trans-arterial procedures, trans-venous procedures, non-vascular procedures, and intra-procedural patient management. Discusses risk management, nursing management, and drugs and dosages. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. "-- Provided by publisher.

This new edition of the principal reference on occupational dermatology provides the most comprehensive updated overview of its clinical management. It contains a number of new and heavily revised chapters, taking into account recent developments in the understanding and clinical management of occupational dermatitis. Since its first publication in 2000, it has served as the main reference on the topic for general and occupational dermatologists, occupational physicians, and health workers in other fields. It provides a comprehensive overview of clinical appearances, epidemiology, diagnostic approaches, contact materials, patient care, and prevention. This third edition of Kanerva?s Occupational Dermatology has been revised and extended to take into account recent developments. The emphasis is very much on evidence-based dermatology, and the coverage is both completely up-to-date and exceptionally detailed. The layout allows for both in-depth reading and quick access to practical information, with the inclusion of concise tables, algorithms, and figures on how to optimize the diagnostic procedure for daily patient management. It continues to ensure that experts and students alike are acquainted with newly emerging conditions and the latest advances.

"Through eight outstanding editions, Kanski's Clinical Ophthalmology has been the classic specialty textbook, providing the perfect ophthalmology foundation for trainees and a valuable reference source for experienced practitioners. Building on the previous edition by Dr. Brad Bowling, Dr. John Salmon from Oxford University has comprehensively revised the textbook. The 9th Edition retains Dr. Kanski's highly effective format of succinct text and visually dynamic presentation, providing authoritative, focused guidance on the diagnosis and management of ophthalmic disorders. Extremely well organized and comprehensive in scope, this visually stunning book reflects the latest advances in the field, facilitating quick comprehension to enhance learning, aid exam preparation and guide clinical practice. As a general ophthalmic textbook, this is the gold standard."--Provided by publisher.

V. 1 -- Neural sciences -- Neuropsychiatry and behavioral neurology -- Contributions of the psychological sciences -- Contributions of the social sciences -- Quantitative and experimental methods in psychiatry -- Theories of personality and psychopathology -- Diagnosis and psychiatry: examination of the psychiatric patient -- Clinical manifestations of psychiatric disorders -- Classification in psychiatry -- Neurocognitive disorders -- Substance-related disorders -- Schizophrenia and other psychotic disorders -- Mood disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Pathological and problem gambling: gambling disorder -- Posttraumatic stress disorder -- Somatic symptom and related disorders -- Factitious disorder -- Dissociative disorders -- Normal sexuality and sexual disorders -- Feeding and eating disorders -- Sleep disorders -- Impulse-control disorders -- Adjustment disorders -- Personality disorders -- V. 2 -- Psychosomatic medicine -- Additional conditions that may be a focus of clinical attention -- Cultural concepts of distress and assessment -- The neuropsychiatry of human aggression -- Special areas of interest -- Psychiatric emergencies -- Psychotherapies -- Biological therapies -- Child psychiatry -- Child psychiatry examination -- Genetics in child psychiatry -- Neuroimaging in psychiatric disorders of childhood -- Temperament: risk and protective factors for child psychiatric disorders -- Intellectual disability -- Specific learning disorder -- Developmental coordination disorder -- Communication disorders -- Autism spectrum disorder and social communication disorder -- Attention-deficit disorders -- Distruptive behavior disorders in children and adolescents -- Feeding and eating disorders of infancy and early childhood -- Tic disorders -- Elimination disorders -- Other disorders of infancy, childhood, and adolescence -- Mood disorders in children and adolescents -- Anxiety disorders in children -- Early-onset psychotic disorders -- Child psychiatry: psychiatric treatment -- Child psychiatry: special areas of interest -- Adulthood -- Geriatric psychiatry -- Public psychiatry -- Psychiatric education -- Ethics and forensic psychiatry -- History of psychiatry -- World aspects of psychiatry -- Appendix A: History of psychiatry table -- Appendix B: Glossary of psychiatry and psychology terms.

Completely revised to bring you up to date with current DSM-5 classifications, new medications, and more, Kaplan & Sadock's Pocket Handbook of Clinical Psychiatry, Sixth Edition, is a concise, easy-to-use guide to diagnosing the full range of psychiatric disorders in both adults and children. Brief summaries of psychiatric disorders include key aspects of etiology, epidemiology, clinical features, and suggestions for treatment--back cover.

Neural sciences -- Contributions of the psychosocial sciences -- Contributions of the sociocultural sciences -- Theories of personality and psychopathology -- Examination and diagnosis of the psychiatric patient -- Classification in psychiatry -- Schizophrenia spectrum and other psychotic disorders -- Mood disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Trauma- and stressor-related disorders -- Dissociative disorders -- Psychosomatic medicine -- Chronic fatigue syndrome and fibromyalgia -- Feeding and eating disorders -- Normal sleep and sleep-wake disorders -- Human sexuality and sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance use and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Emergency psychiatric medicine -- Complementary and alternative medicine in psychaitry -- Other conditions that may be a focus of clinical attention -- Physical and sexual abuse of adults -- Psychiatry and reproductive medicine -- Psychotherapies -- Psychopharmacological treatment -- Brain stimulation methods -- Child psychiatry -- Adulthood -- Geriatric psychiatry -- End-of-life issues -- Public psychiatry -- Forensic psychiatry and ethics in psychiatry -- World aspects of psychiatry.

"The 11th Edition of Kaplan's Clinical Hypertension continues to integrate the latest basic science findings and clinical trial data to provide current, practical, evidence-based recommendations for treatment and prevention of all forms of hypertension. As in previous editions, abundant algorithms and flow charts are included to aid clinicians in decision-making."--Provided by publisher.

Cardiac risk, imaging, and the cardiology consultation -- Cardiac catheterization laboratory : diagnostic and therapeutic procedures in the adult patient -- Cardiac electrophysiology : diagnosis and treatment -- Cardiac physiology -- Coronary physiology and atherosclerosis -- Molecular and genetic cardiovascular medicine and systemic inflammation -- Pharmacology of anesthetic drugs -- Cardiovascular pharmacology -- Electrocardiographic monitoring -- Monitoring of the heart and vascular system -- Basic intraoperative transesophageal echocardiography -- Central nervous system monitoring -- Coagulation monitoring -- Anesthesia for myocardial revascularization -- Valvular heart disease : replacement and repair -- Congenital heart disease in adults -- Thoracic aorta -- Uncommon cardiac diseases -- Anesthesia for heart, lung, and heart-lung transplantation -- Pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension -- Procedures in the hybrid operating room -- Mechanical assist devices for heart failure -- Reoperative cardiac surgery -- Patient safety in the cardiac operating room -- Cardiopulmonary bypass management and organ protection -- Extracorporeal devices including extracorporeal membrane oxygenation -- Transfusion medicine and coagulation disorders -- Discontinuing cardiopulmonary bypass -- Postoperative respiratory care -- Postoperative cardiovascular management -- Central nervous system dysfunction after cardiopulmonary bypass -- Long-term complications and management -- Postoperative pain management for the cardiac patient.

The chapters in Essentials of Cardiac Anesthesia for Noncardiac Surgery have been written by acknowledged experts in each specific area, and the material has been coordinated to maximize its clinical value. Recent information has been integrated from anesthesiology, surgery, cardiology, critical care medicine, and clinical pharmacology to present a complete clinical picture. This “essential” information will assist the clinician in understanding the basic principles of each subject and facilitate their application in practice. Because of the large volume of information presented, several teaching aids have been included to help highlight the most important clinical information. Teaching boxes include many of the key take-home messages. In addition, the Key Points at the start of each chapter highlight the major areas covered. Finally, each chapter includes a list of Suggested Reading for additional information, rather than an extensive list of references.

PART I: BASIC PRINCIPLES -- Chapter 1: Introduction -- Chapter 2: Pharmacodynamics -- Chapter 3: Pharmacokinetics -- Chapter 4: Drug Metabolism -- Chapter 5: Pharmacogenomics -- PART II: AUTONOMIC DRUGS -- Chapter 6: Introduction to Autonomic Pharmacology -- Chapter 7: Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs -- Chapter 8: Cholinoceptor Blockers & Cholinesterase Regenerators -- Chapter 9: Sympathomimetics -- Chapter 10: Adrenoceptor Blockers -- PART III: CARDIOVASCULAR DRUGS -- Chapter 11: Drugs Used in Hypertension -- Chapter 12: Drugs Used in the Treatment of Angina Pectoris -- Chapter 13: Drugs Used in Heart Failure -- Chapter 14: Antiarrhythmic Drugs -- Chapter 15: Diuretics & Other Drugs That Act on the Kidney -- PART IV: DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE -- Chapter 16: Histamine, Serotonin, & the Ergot Alkaloids -- Chapter 17: Vasoactive Peptides -- Chapter 18: Prostaglandins & Other Eicosanoids -- Chapter 19: Nitric Oxide, Donors, & Inhibitors -- Chapter 20: Drugs Used in Asthma & Chronic Obstructive Pulmonary Disease -- PART V: DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM -- Chapter 21: Introduction to CNS Pharmacology -- Chapter 22: Sedative-Hypnotic Drugs -- Chapter 23: Alcohols -- Chapter 24: Antiseizure Drugs -- Chapter 25: General Anesthetics -- Chapter 26: Local Anesthetics -- Chapter 27: Skeletal Muscle Relaxants -- Chapter 28: Drugs Used in Parkinsonism & Other Movement Disorders -- Chapter 29: Antipsychotic Agents & Lithium -- Chapter 30: Antidepressants -- Chapter 31: Opioid Analgesics & Antagonists -- Chapter 32: Drugs of Abuse -- PART VI: DRUGS WITH IMPORTANT ACTIONS ON BLOOD, INFLAMMATION, & GOUT -- Chapter 33: Agents Used in Cytopenias; Hematopoietic Growth Factors -- Chapter 34: Drugs Used in Coagulation Disorders -- Chapter 35: Agents Used in Dyslipidemia -- Chapter 36: NSAIDs, Acetaminophen, & Drugs Used in Rheumatoid Arthritis & Gout -- PART VII: ENDOCRINE DRUGS -- Chapter 37: Hypothalamic & Pituitary Hormones -- Chapter 38: Thyroid & Antithyroid Drugs -- Chapter 39: Corticosteroids & Antagonists -- Chapter 40: Gonadal Hormones & Inhibitors -- Chapter 41: Pancreatic Hormones, Antidiabetic Agents, & Glucagon -- Chapter 42: Drugs That Affect Bone Mineral Homeostasis -- PART VIII: CHEMOTHERAPEUTIC DRUGS -- Chemotherapeutic Drugs: Introduction -- Chapter 43: Beta-Lactam Antibiotics & Other Cell Wall Synthesis Inhibitors -- Chapter 44: Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, Streptogramins, & Linezolid -- Chapter 45: Aminoglycosides -- Chapter 46: Sulfonamides, Trimethoprim, & Fluoroquinolones -- Chapter 47: Antimycobacterial Drugs -- Chapter 48: Antifungal Agents -- Chapter 49: Antiviral Chemotherapy & Prophylaxis -- Chapter 50: Miscellaneous Antimicrobial Agents & Urinary Antiseptics -- Chapter 51: Clinical Use of Antimicrobials -- Chapter 52: Antiprotozoal Drugs -- Chapter 53: Antihelminthic Drugs -- Chapter 54: Cancer Chemotherapy -- Chapter 55: Immunopharmacology -- PART IX: TOXICOLOGY -- Chapter 56: Environmental & Occupational Toxicology -- Chapter 57: Heavy Metals -- Chapter 58: Management of the Poisoned Patient -- PART X: SPECIAL TOPICS -- Chapter 59: Drugs Used in Gastrointestinal Disorders -- Chapter 60: Dietary Supplements & Herbal Medications -- Chapter 61: Drug Interactions -- Appendix I: Strategies for Improving Test Performance -- Appendix II: Key Words for Key Drugs.

"This book is designed to help students review pharmacology and to prepare for both regular course examinations and board examinations. The twelfth edition has been revised to make such preparation as active and efficient as possible. As with earlier editions, rigorous standards of accuracy and currency have been maintained in keeping with the book's status as the companion to the Basic & Clinical Pharmacology textbook."--Preface

"This book is designed to help students review pharmacology and to prepare for both regular course examinations and board examinations"--Preface.

Completely revised in response to the new format of the ABPN certifying exam, Kaufman's Clinical Neurology for Psychiatrists is the ideal reference to enhance your mastery of the neurology knowledge needed for the Psychiatry Board exam. Nearly 2,000 multiple-choice practice questions, in print and online, assess your familiarity with the latest topics in the field! Enhance your mastery of the material with the help of abundant line drawings, CTs, MRIs, and EEGs that demonstrate key clinical findings to facilitate diagnosis.Fully understand each condition's relevant history, neurologic and psychiatric features, easily performed office and bedside examinations, appropriate tests, differential diagnosis, and management options.

Section 1 Classic anatomic neurology -- 1. First encounter with a patient -- 2. Signs of central nervous system disorders -- 3. Psychogenic neurologic deficits -- 4. Cranial nreve impairments -- 5. Peripheral nerve disorders -- 6. Muscle disorders -- Section 2 Major neurologic symptoms -- 7. Dementia -- 8. Aphasia and anosognosia -- 9. Headaches -- 10. Epilepsy -- 11. TIAs and strokes -- 12. Visual disturbances -- 13. Congenital cerebral impairments -- 14. Neurologic aspects of chronic pain -- 15. Multiple sclerosis -- 16. Neurologic aspects of sexual function -- 17. Sleep disorders -- 18. Involuntary movement disorders -- 19. Brain tumors, Metastatic cancer, and paraneoplastic syndromes -- 20. Lumbar puncture and imaging studies -- 21. Neurotransmitters and drug abuse -- 22. Traumatic brain injury -- Appendix 1 Patient and family support groups -- Appendix 2 Costs of various tests and treatments -- Appendix 3 Diseases transmitted by chromosome or mitochondria abnormalities -- Appendix 4 Chemical and biological neurotoxins.

This book aims to provide readers with up-to-date information on clinical research, diagnostic methods and treatment choice of Kawasaki disease. First chapters describe clinical symptoms, diagnosis, treatment, and complications of Kawasaki disease. Hot topics of precision medicine, big data analysis, genetics study, psychologic problems and allergic diseases after Kawasaki diseases are also discussed in details. Written by experts with wealthy experience in the field, this book will be an invaluable reference for pediatricians and clinicians working in the field of Kawasaki disease.

The Perinatal Postmortem from a Clinician?s Viewpoint -- The Perinatal Necropsy: Methodology -- Genetic and Epigenetic Basis of Development and Disease -- The Placenta and Umbilical Cord -- Perinatal Imaging -- Epidemiology of Fetal and Neonatal Death -- Pathology of Early Pregnancy Loss -- Congenital Abnormalities: Prenatal Diagnosis and Screening -- The Impact of Infection During Pregnancy on the Mother and Baby -- Perinatal Haematology -- Genetic Metabolic Disease -- Fetal Hydrops -- Pathology of Twinning -- Macerated Stillbirth -- Intrapartum Problems -- Prematurity -- Iatrogenic Disease -- Congenital Tumors -- The Cardiovascular System -- The Respiratory System -- The Alimentary Tract and Exocrine Pancreas -- Liver and Gallbladder -- The Urinary System -- The Reproductive System -- The Endocrine System -- The Reticuloendothelial System -- Brain Malformations -- Degenerative and Metabolic Brain Diseases -- Acquired Diseases of the Nervous System -- Skeletal Muscle and Peripheral Nerves -- The Skeletal System -- The Skin -- The Special Senses.- Forensic Aspects of Perinatal Pathology.

This sixth edition provides an overview of fetal and neonatal pathology through a system-based approach. This book contains new chapters on immunology, with a continued focus on molecular aspects of pathology in the perinatal setting. The general principles of perinatal pathology and their clinical situations are also discussed, along with specific pathological entities and their organ systems. Keeling's Fetal and Neonatal Pathology, sixth edition aims to help the reader treat common problems through anatomical pathology findings and is relevant to practicing and trainee pathologists, obstetricians, maternal and fetal medicine specialists, neonatologists, and pediatricians.

Section 1: General basic and clinical considerations. The history and physical examination -- Molecular determinants of lung morphogenesis -- Basic genetics and epigenetics of childhood lung disease -- Environmental contributions to respiratory disease in children -- The surfactant system -- The structural and physiologic basis of respiratory disease -- Biology and assessment of airway inflammation -- Lung defenses: intrinsic, inate and adaptive -- Bronchoscopy and brochoalveolar lavage in pediatric patients -- Diagnostic imaging of the respiratory tract -- Pulmonary function tests in infants and preschool children -- Excercise and lung function in child health and disease -- Integrating patient reported outcomes into research and clinical practice -- Transition from pediatric to adult care -- Long term consequences of childhood respiratory disease -- Drug administration by inhalation in children -- Physical therapies in pediatric respiratory disease -- Congenital lung disease -- Respiratory disorders in the newborn -- Bronchopulmonary dysplasia -- Children dependent on respiratory technology -- Section 2: Infections of the lung. Microbiological diagnosis of respiratory illness: recent advances -- Acute infections that produce upper airway obstruction -- Bronchiolitis -- Pneumonia in children -- Bronchiectasis and chronic suppurative lung disease -- Influenza -- New and emerging infections of the lung -- Tuberculosis -- Non -tuberculosis mycobacterial disease -- The mycoses -- Pertussis and other bordetella infections of the respiratory tract -- Toxocariasis, hydatid disease of the lung, strongyloidiasis, and pulmonary paragonimiasis -- Section 3: Pulmonary disease in the intensive care unit. Principles of mechanical ventilation -- Childhood pulmonary arterial hypertension -- Pulmonary edema -- Respiratory complications of intensive care -- Acute respiratory distress syndrome -- Pulmonary disease associated with congenital heart disease -- Lung injury from hydrocarbon aspiration and smoke inhalation -- Drowning -- Section 4: Asthma. The epidemiology of asthma -- The immunopathogenesis of asthma -- Asthma in the preschool age child -- Wheezing in older children: asthma -- Severe asthma -- The influence of upper airway disease on the lower airway -- Modern molecular therapies for application in managing childhood asthma -- Section 5: Cystic fibrosis. Genetics and pathophysiology of cystic fibrosis -- Diagnosis and presentation of cystic fibrosis -- Pulmonary disease in cystic fibrosis -- Non-pulmonary manifestations of cystic fibrosis -- Modern molecular therapies for CF -- Section 6: Interstitial lung disease. New concepts in children's interstitial lung disease and diffuse lung disease -- Rare and new childhood lung disorders -- Childhood interstitial lung disease disorders more prevalent in infancy -- Lung diseases associated with disruption of pulmonary surfactant homeostasis -- Pulmonary involvement in the systemic diseases of childhood -- Lung injury caused by pharmacologic agents -- Section 7: Miscellaneous disorders of the lung. Pulmonary embolism and thromboembolic disease -- Diffuse alveolar hemorrhage in children -- The lung in sickle cell disease -- Primary immunodeficiency: and other diseases with immune disregulation -- Pulmonary disease in the immunosuppressed pediatric patient -- Hypersentivity pneumonitis and eosinophilic lung diseases -- Respiratory disorders in HIV-infected children and adolescents -- Pediatric lung transplantation -- Respiratory complication of down syndrome and other genetic syndromes -- Air and liquid in the pleural space -- Atelectasis -- Primary ciliary dyskinesia -- Chest wall and respiratory muscle disorders -- Disorders of the respiratory tract caused by trauma -- Tumors of the chest -- Section 8: The aerodigestive model. The aerodigestive model -- Aspiration -- Feeding swallowing and voice disorders -- Gastroesophageal reflux disease and eosinophilic esophagitis in children with complex airway disease -- Laryngeal and tracheal airway disorders -- Sudden infant death syndrome and apparent life threatening events -- Disorders of breathing during sleep.

Kenneth Warren was a powerful figure in twentieth century medicine whose work transformed public health policy and tropical medicine, and who left a profound legacy in global health thinking. A prolific writer and researcher, Warren was respected for his scientific research, winning awards and accolades, while his later role as activist, agitator, innovator and connoisseur of science brought him international recognition. His career in medicine is remembered for three enduring achievements: · His efforts to introduce modern biomedical science to the study of infectious diseases in the developing world · The proselytising energy he brought to the ethical challenge of how to provide the most cost-effective health care to the world's poorest people · His tenure as Director of Health Sciences at the Rockefeller Foundation, during which time he inaugurated the Great Neglected Diseases of Mankind Programme Told through personal interviews with both Warren's supporters and detractors, the story of Warren's career, inexorably interwoven with the GND programme, is a compelling narrative that has not only enduring implications for current medical research, funding and healthcare across the globe, but also a long-standing legacy for the future ways in which we combat disease in the developing world.

Keratoconus is a progressive disease of the cornea which can lead to blindness as irregular astigmatism increases. The study of the ectasic diseases of the cornea has evolved considerably in the last several years and this has brought new tools for the keratoconus diagnosis and treatment. A better understanding of treatment options can enhance visual rehabilitation and prevent blindness in these patients. This book provides the reader deeply and updated information on keratoconus treatment. Written by experts from worldwide, presents clinical, genetic, metabolic and biomechanical aspects in the development of the disease, the proper intervention time, the imaging tests used for diagnosis and keratoconus monitoring, as well as details new surgical procedures (as contact lenses and laser technologies) using modern methods with wide technological application. Two pioneers in the keratoconus treatment bring their valuable contribution in specific chapters. Ophthalmologists will find a practical and useful approach of new technologies to get the best results for their patients. This book will really impact changes in the therapeutic conduct of corneal surgeons.

This book provides a practical guide to the most recent advances in the diagnostic management of corneal ectasia. Clear, concise chapters address new standardized nomograms of treatment of early progressive ectasia, new epithelium on future crosslinking with and without oxygen supplement, customized protocols, laser assisted corneal regularization protocols and the new femtolaser assisted lamellar corneal transplant. Clinicians and surgeons seeking a go-to guide on the topic of corneal ectasia will find this book to be an essential resource for the latest developments and predicted future trends in the field.

"Offering practical clinical guidance for early diagnosis and effective management, Keratoconus: Diagnosis and Management is a concise, easy-to-read guide to help mitigate loss of vision in patients in a way that does not interfere with quality of life. From early diagnosis and intervention through the most up-to-date treatment and surgical approaches, this consolidated reference covers the essential information needed by cornea fellows and specialists, general ophthalmologists, residents, and optometrists"--Provided by publisher.

The book covers various aspects of the management of keratoconus, which is a leading cause of visual impairment in young adults. It focuses on the epidemiology and risk factors of keratoconus with a special focus on Southeast Asia. Keratoconus affects the quality of vision, thereby affecting the quality of life. While most patients present with defective vision, many are diagnosed accidentally during screening for refractive surgery. The book covers the varied epidemiology of keratoconus across different parts of the world. It discusses many systemic and ocular diseases associated with keratoconus. The book covers the newer diagnostic techniques and various treatment procedures for keratoconus, helping in diagnosing keratoconus in the early stages and closely watching the progression. It discusses various contact lenses to improve vision quality; widely used collagen crosslinking, and its various modifications for halting the progression. It also explains the surgical approach for keratoconus, such as penetrating keratoplasty, lamellar keratoplasty and other lens-assisted procedures. The book is relevant for general ophthalmologists and cornea specialists.

This book covers the field of keratoprosthesis in detail and focuses specifically on the Boston type 1 keratoprosthesis (KPro), which is the device most widely used today. Extensive information is provided on all aspects of KPro surgery, from history and preoperative evaluation to surgical techniques and postoperative management of complications. Surgical videos are included that will aid both beginning and advanced corneal surgeons in mastering these procedures. In addition, essential basic science concepts relevant to keratoprosthesis surgery are explained, and other keratoprostheses in use around the world are considered. A brief overview of integrating artificial corneas is provided, and the future of keratoprosthesis is also discussed. The book is written by some of the most distinguished and renowned experts in the field.

--1. The cardiac catheterization laboratory -- 2. Arterial and venous access -- 3. Coronary angiography and ventriculography -- 4. Invasive hemodynamics -- 5. Peripheral arterial disease and angiography -- 6. Interventional cardiology procedures -- 7. The electrophysiology laboratory and electrophysiologic procedures -- 8. High-risk cardiac catheterization -- 9. Special techniques -- 10. Research techniques -- 11. Optimization of quality in the cardiac catheterization laboratory --

"The family Falconidae constitutes a group of small to medium-sized diurnal raptors whose monophyly is strongly supported. Kestrels are included in the subfamily Falconinae. There are at least 13 species that belong to the kestrel group, but recent genetic studies suggest that the number of kestrel species might be larger, possibly 16. The paleontological and molecular evidences are congruent in suggesting an evolutionary radiation of kestrels from the Late Miocene (5.6 to 9.8 million years ago) through the Early Pleistocene"-- Provided by publisher.

This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. -- Provided by publisher.

1. History of Ketamine Use and its Clinical Indications -- 2. Basic and Clinical Pharmacology of Ketamine -- 3. Ketamine: Clinical Studies in Treatment-Resistant Depressive Disorders -- 4. Ketamine and Suicidality -- 5. Ketamine: Safety, Tolerability, and Impact on Neurocognition -- 6. Ketamine's Mechanisms of Rapid Antidepressant Activity: Evidence Gleaned from Pre-Clinical Studies -- 7. Ketamine's Mechanisms of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies -- 8. Ketamine and Electroconvulsive Therapy -- 9. Beyond Depressive Disorders: Emerging Data for the Use of Ketamine in OCD, PTSD, and Alcohol/Substance Use Disorders.

Key Advances in Clinical Informatics: Transforming Health Care through Health Information Technology provides a state-of-the-art overview of the most current subjects in clinical informatics. Leading international authorities write short, accessible, well-referenced chapters which bring readers up-to-date with key developments and likely future advances in the relevant subject areas. This book encompasses topics such as inpatient and outpatient clinical information systems, clinical decision support systems, health information technology, genomics, mobile health, telehealth and cloud-based computing. Additionally, it discusses privacy, confidentiality and security required for health data. Edited by internationally recognized authorities in the field of clinical informatics, the book is a valuable resource for medical/nursing students, clinical informaticists, clinicians in training, practicing clinicians and allied health professionals with an interest in health informatics.

Short case studies, based on real stories from the health care arena, ensure that each chapter of this book is rooted in descriptions of nursing practise that are grounded, salient narratives of nursing care. The reader is assisted to explore the ethical dimension of nursing practice: what it is and how it can be portrayed, discussed, and analysed within a variety of practice and theoretical contexts. One of the unique contributions of this book is to consider nursing not only in the context of the individual nurse-patient relationship but also as a social good that is of necessity limited, due to the ultimate limits on the nursing and health care resource. This book will help the reader consider what good nursing looks like, both within the context of limitations on resources and under conditions of scarcity. Indeed, any discussion of ethical issues in nursing should be well grounded in a conceptualisation of nursing that nursing students and practising nursing can recognise, accept and engage with. Nursing, like medicine, social work and teaching has a clear moral aim--to do good. In the case of nursing to do good for the patient. However it is vital that in the pressurised, constrained health service of the 21st century, we help nurses explore what this might mean for nursing practice and what can reasonably be expected of the individual nurse in terms of good nursing care.

This book adds in chapter 1 and 2 the MIN-key techniques Laser and sealing, completing the 3 MIN-key techniques of the first volume. In chapter 3 the evolution of anatomy to a key-concept of MIN is described, presenting theory and reality of anatomical perspectives that can be used by the MIN-surgeon directly in the OR. Anatomy must be elaborated according to Gestalt-Theory to become a Key of MIN. Still anatomy is the "House of Medicine", giving a mental place to all knowledge, theories and biological functions. The "surgical simulation concept" of chapter 4 as trainings environment follows, also as a key-concept of MIN. In this chapter we draw the line from Gestalt-Anatomy to a Surgical Simulation Application in Pathological Anatomy exemplified in aneurysm cases. Chapter 5 presents the best preservation technique of anatomical perishable matter, forming durable, dry and odorless specimen of unknown precision and beauty. The scientific value of this unique technique and the benefit for MIN are shown by many examples.With the Plastination gallery of chapter 6 the best head-plastinates and sheet-plastinates of head and brain complete the volume. Many of the specimen have been shown around the globe in the famous exhibitions "body worlds" (Prof. Dr. G. v. Hagens/Inventor of Plastination).

This book presents a wealth of images of the different diseases and conditions encountered in the field of uroradiology with the aim of enabling the reader to recognize lesions, to interpret them appropriately, and to make correct diagnoses. The images have been selected because they depict typical or classic findings and provide a route to lesion recognition that is superior to memorization of descriptions. The imaging modalities represented include CT, CT angiography, CT urography, MRI, MRA, MRU, diffusion-weighted MRI and ADC mapping, dynamic contrast-enhanced MRI, sonography, conventional angiography, excretory urography, retrograde pyelography, cystography, urethrography, and voiding cystourethrography. For each depicted case, important imaging features are highlighted and key points identified in brief accompanying descriptions. Readers will find that the book provides excellent guidance in the selection of imaging modalities and facilitates diagnosis. It will be an ideal ready source of information on key imaging features of urinary tract diseases for medical students, residents, fellows, and physicians handling these diseases.

Simulation Training in the Intensive Care Unit -- Assessment and management of the delirious patient in the Intensive Care Unit -- Management of stroke in a non neuro-intensive care unit -- Neuropsychological Rehabilitation for Critically Ill Patients -- Pain in Intensive Care -- Regional Anaesthesia in the Intensive Care Unit -- Dynamic Assessment of the Heart-Echocardiography in the Intensive Care Unit -- The Role of Lung Ultrasound on the Daily Assessment of the Critically Ill Patient -- Acute Liver Failure: Diagnosis and Management for the General Intensive Care -- The Initial Surgical Management of the Critically Ill Burn Patient -- The Critically Ill Burn Patient -- How do we get it right? -- Venous Thromboembolism Prevention and the Role of Non-Coumarin Oral Anticoagulants in the Intensive Care Units -- Magnesium and Cell Membrane Stability in the Critically Ill Patient -- Transfer of the Sickest Patient in the Hospital: When, How and by Whom.

"The book offers a comprehensive and up-to-date overview of key issues in perinatal mental health. Classic topics such as screening, assessment, pharmacological, psychological and psychosocial interventions of the most common conditions (depression, anxiety disorders, etc.) are combined with lesser known issues, such as mother-infant relationship disorders or thoughts of infant-related harm and aggressive behaviors, sleep disturbances in puerperium, obsessional disorders, fetal death etc., paying particular attention to specific groups of perinatal patients like mothers with cancer, adolescents, fathers, migrants, and preterm babies. The chapters written by health professionals working in hospitals, community services or voluntary agencies alternate with contributions from researchers whose fields of expertise include biology and neuroscience, diagnosis and special needs, treatment and prognosis, etc., striking a balance between scientific investigation and clinical practice.The book offers a valuable tool for a wide range of professionals like psychiatrists, psychologists, gynecologists, midwives, oncologists, pediatricians, and social workers, who want to improve their clinical practice and the effectiveness of their treatment pathways using evidence from perinatal health research."-- Provided by publisher

Keys to Running Successful Research Projects: All the Things They Never Teach You provides a step-by-step guide for the management of a successful research project or program. Through the use of illustrative case studies, the book covers all aspects of management that should be included during researcher training, helping researchers overcome the many challenges they face in their day-to-day management of people, time and resources. Links throughout provide more detailed information from gold standard sources on every topic. It is a must-have reference for postdocs, research managers and administrators in colleges, universities, hospitals and research institutes. In addition, it is an ideal resource for those working in grant and contract funding groups in the life sciences and medical fields.

This book provides clear guidance on how to achieve excellent functional results and avoid failures when performing cystectomy and orthotopic bladder substitution. The opening sections present helpful checklists relating to patient selection, preoperative management, the procedures themselves, intraoperative measures, postoperative management, and actions to be taken in the event of various symptoms and complications. The remainder of the book focuses in detail on a variety of specific points of interest such as how and why to attempt a nerve-sparing cystectomy, the role of pelvic lymph node dissection, physical and physiological considerations relevant to reservoir construction, metabolic consequences of the incorporation of bowel into the urinary tract, preservation of renal function, and quality of life issues. The information provided may not only be instrumental to urologists, but also to specialized health care professionals, as well as the concerned patients.

Structure of matter -- Nuclear transformations -- Production of x-rays -- Clinical radiation generators -- Interactions of ionizing radiation -- Measurement of ionizing radiation -- Quality of x-ray beams -- Measurement of absorbed dose -- Dose distribution and scatter analysis -- A system of dosimetric calculations -- Treatment planning i : isodose distributions -- Treatment planning ii : patient data acquisition, treatment verification, and -- Inhomogeneity corrections -- Treatment planning iii: field shaping, skin dose, and field separation -- Electron beam therapy -- Low-dose-rate brachytherapy: rules of implantation and dose specification -- Radiation protection -- Quality assurance -- Total body irradiation -- Three-dimensional conformal radiation therapy -- Intensity-modulated radiation therapy -- Stereotactic radiotherapy and radiosurgery -- Stereotactic body radiation therapy -- High-dose-rate brachytherapy -- Prostate implants: technique, dosimetry, and treatment planning -- Intravascular brachytherapy -- Image-guided radiation therapy -- Proton beam therapy.

"This edition includes new chapters and updates of prior chapters designed to keep pace with the many exciting innovations in radiation oncology. It is our hope that this edition will bring readers from yesterday's standard of care to today's state of the art and provide a peek over the horizon at the dawn of a new era in which the science and the art of radiation oncology come together as never before. The science includes new understanding of the potential lurking within discoveries in physics, biology and technology. The art is the integrated clinical application of those discoveries, in concert with advances in systemic therapies. For example, there is a new chapter on the treatment planning implications of combined immunotherapy and radiation. This and other chapters hold clues that may lead us beyond local control of an individual tumor to a future in which a systemic response may be ignited by the application of modern radiation techniques and systemic therapies in proper sequence and intensity. In addition, there is a re-focus on the patient, beginning with a new chapter on treatment planning and patient safety"-- Provided by publisher.

Section I: General considerations. Surgical approaches to the heart and great vessels -- Preparation for cardiopulmonary bypass -- Myocardial preservation -- Venting and deairing of the heart -- Section II: Surgery for acquired heart disease. Surgery of the aortic valve -- Surgery of the mitral valve -- Surgery of the tricuspid valve -- Surgery of the aorta -- Surgery for coronary disease -- Surgery for mechanical complications of myocardial infarction -- Heart transplantation -- Cardiac tumors -- Surgery for atrial fibrillation -- Section III: Surgery for congenital heart defects. Patent ductus arteriosus -- Coarctation of the aorta -- Pulmonary artery banding -- Vascular ring and pulmonary artery sling -- Systemic pulmonary shunting -- Atrial septal defect -- Total anomalous pulmonary venous connection -- Ventricular septal defect -- Atrioventricular septal defect -- Right ventricular outflow tract obstruction -- Left ventricular outflow tract obstruction -- Transposition of the great vessels -- Aortopulmonary window -- Truncus arteriosus -- Ebstein anomaly -- Interrupted and hypoplastic aortic arch -- The Norwood principle -- The Fontan principle -- Coronary artery anomalies.

Embryology, Anatomy and Histology of the Kidney -- Polycystic Kidney Disease -- Non-Neoplastic Disease Presenting as a Renal Lesion -- Overview and Staging of Renal Neoplasms -- Conventional Forms of Renal Neoplasia -- Familial Forms of Renal Cell Carcinoma and Associated Syndromes -- Translocation-Associated Carcinoma -- Collecting Duct Carcinoma and Renal Medullary Carcinoma -- Emerging and Recently Described Subtypes of Renal Carcinoma -- Non-Epithelial Renal Neoplasms of the Adult Kidney -- Pediatric Renal Neoplasms -- Glomerular Disease -- Non-Neoplastic Kidney Diseases in the Setting of a Renal Mass.

"A guide to creating a multi-disciplinary program approach to kidney and pancreas transplantation"-- Provided by publisher.

Embryology of the Urinary Tract -- Normal Development of Renal Function of the Newborn -- Fluid and Electrolytes in the Newborn -- Special Considerations -- Tools for the Assessment of Renal Function in the Newborn -- Oral and Parenteral Nutrition of the Newborn with Urinary Tract Disease -- Fetal Urology -- Imaging of the Urinary Tract in Newborns -- Urinary Tract Infections -- Hydronephrosis -- Posterior Urethral Valves -- Prune Belly Syndrome -- Structural Abnormalities of the External Genitalia and Urinary Tract -- Structural Abnormalities of the kidney and Ureter -- Neonatal Tumors involving the Urinary Tract -- Cystic Kidney Disease -- Congenital Nephrotic Syndrome -- Acute Kidney Injury -- Renal Replacement Therapy in the Neonate -- Neonatal Hypertension -- Electrolyte Abnormalities in the Newborn.

Part 1: Epidemiology and Biology Epidemiology of Kidney Cancer -- Pathological Classification -- Molecular Biology of Kidney Cancer -- Biomarkers for Kidney Cancer -- Genetic Heterogeneity of Kidney Cancer -- Metabolic Basis of Kidney Cancer. Part 2: Clinical Considerations Clinical Presentation and Staging.- Hereditary Kidney Cancer. Part 3: Surgical and Local Control Modalities Surgical Approaches to Early Stage Kidney Cancer -- Cytoreductive Nephrectomy -- Metastasectomy -- Energy Ablative Techniques in Kidney Cancer -- The Role of Radiation Therapy in Kidney Cancer. Part 4: Systemic Therapy Considerations Adjuvant Systemic Therapy -- Cytokines and Vaccine Therapy -- PD1 and PDL1 Targeted Therapy -- Angiogenesis Inhibitor Therapy -- The Role of mTOR inhibitors and PI3K Pathway Blockade -- Sequential versus Combination Strategies -- Presurgical Therapy in Kidney Cancer -- Toxicity Management for Patients on Targeted Therapies -- Emerging Agents in Kidney Cancer.

This book provides a comprehensive overview of pathology of kidney tumors along with radiological features and up to date treatment strategies that enable the readers to avail this information in day to day pathology sign-out as well as interaction with clinical colleagues of different disciplines. It also serves as a referral resource for the current medical or surgical practice while preparing for examinations or maintenance of certification. Written by experts in the field, chapters contain an updated review of important pathologic parameters mandated for diagnosis and reporting with emphasis on updated information regarding new developments in this interesting field. Numerous high-resolution color images aptly illustrate the various pathologic entities and their features as outlined in the text section along with tables that highlight the differential diagnoses and salient ancillary features. Kidney Cancer serves as a quick reference for all categories of readers alike, and provides up-to-date information on renal tumor pathology, radiology and management that are required in daily practice.

Drosophila Malpighian tubules: a model for understanding kidney development, function, and disease / Naveen Kumar Gautam, Puja Verma, and Madhu G. Tapadia -- Zebrafish pronephros development / Richard W. Naylor, Sarah S. Qubisi, and Alan J. Davidson -- Zebrafish as a model of kidney disease / Elvin E. Morales and Rebecca A. Wingert -- Use of Xenopus frogs to study renal development/repair / Shoshoni T. Droz and Kelly A. McLaughlin -- Tissue-specific functions of p53 during kidney development / Zubaida Saifudeen -- Growth factor regulation in the nephrogenic zone of the developing kidney / Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown -- Development and diseases of the collecting duct system / Lihe Chen, Paul J. Higgins, and Wenzheng Zhang -- Origin and function of the renal stroma in health and disease / Christopher J. Rowan, Sepideh Sheybani-Deloui, and Norman D. Rosenblum -- Imaging, analysing and interpreting branching morphogenesis in the developing kidney / Kieran M. Short and Ian M. Smyth -- Genetic syndromes affecting kidney development / Abhijeet Pal and Kimberly J. Reidy -- Primary cilia in cystic kidney disease / Prachee Avasthi, Robin L. Maser, and Pamela V. Tran -- Inflammation and fibrosis in polycystic kidney disease / Cheng Jack Song, Kurt A. Zimmerman, Scott J. Henke, and Bradley K. Yoder -- Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): role and implications in kidney fibrosis / Ana S. Cruz-Solbes and Keith Youker.

This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding, and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life, and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists, and researchers with an interest in kidney diseases.

This book is the first title that focuses exclusively on kidney disease and its impact in the cardiac catheterization laboratory. The increasing prevalence of vascular risk factors such as diabetes, obesity and hypertension coupled with increased longevity has resulted in a worldwide epidemic of cardiovascular and chronic kidney disease (CKD). Never has the impact of one organ system on the other been so profound, as in the current context of cardio-renal interactions. The cross talk between the heart and kidneys is highly relevant in the field of interventional cardiology, given the increasing number of trans-catheter procedures being performed in patients with underlying kidney disease. These procedures also have a significant impact on kidney function and require thoughtful interdisciplinary planning by a cardiorenal team, to achieve optimal outcomes This book assembles the collective expertise of several international leaders in the field of interventional cardiology and nephrology to summarize this complex interface. The book is divided into seven sections to comprehensively cover the topic, including sections on best practices with reduction of contrast associated acute kidney injury, cutting edge techniques to minimize kidney risk with complex interventions, impact of transcatheter valvular procedures on kidney function and the utility of cardio-nephrology teams. Less recognized complications with high morbidity such as athero-embolic renal disease are featured prominently, to increase awareness in the interventional cardiology and nephrology communities. This book is a valuable resource for interventional and structural cardiologists, general cardiologists and nephrologists dealing with the significant overlap areas between these two specialties. It is also relevant to medical students, trainee physicians in nephrology and cardiology, advanced care practitioners and nursing personnel in both specialties . Given the major impact of kidney function on outcome s in patients undergoing cardiac procedures, this textbook serves as a focal point to integrate relevant clinical data from both specialties and help interventional cardiologists achieve optimal outcomes, especially in patients with (or at risk for) kidney disease.

This practical guide helps readers take charge of their health and explores the best ways to eliminate this painful disease. Kidney Stone Disease: Say NO to Stones! looks at the formation and prevention of the four major types of kidney stones, explores several different treatment options including open surgery and provides guidance on what to expect before, during and after treatment. Case histories are found at the end of each chapter to guide the reader on the different types of treatment appropriate for specific conditions. Written by a team of experts in the field, Kidney Stone Disease: Say NO to Stones! includes the latest information on risk factors, dietary and lifestyle choices, as well as state-of-the-art treatments.

"With the increased prevalence of kidney transplantation, transplant recipients are being treated in a variety of clinical settings -- often beyond the transplant center. There is a greater need for clinicians and allied healthcare professionals to have appropriate guidance on managing these patients. Kidney Transplantation offers the latest evidencebased information on the full range of dilemmas in the medical management of kidney transplant recipients before, during and after transplantation. Beginning with the selection of patients who are candidates for transplantation, this authoritative guide covers the care of the patient on the waiting list and evaluation of donors, preoperative care, induction and immunosuppression maintenance. This wealth of new information and guidelines will serve as an important resource for the best possible care for transplant patients."--Publisher's website.

This book presents state of the art knowledge on all aspects of kidney transplantation in recipients in whom desensitization strategies are necessary in order to overcome immunologic barriers such as anti-human leukocyte antigen (HLA) donor-specific antibody and ABO blood group incompatibility. Readers will find detailed, up-to-date information on the various immunomodulating therapies that may be employed in these circumstances and the outcomes that may be expected. Full guidance is provided on preoperative evaluation and management and post-transplantation care. In addition, the pathology of antibody-mediated rejection and acute cellular rejection in this context is discussed. For most patients with end-stage renal disease, kidney transplantation offers significant benefits compared with dialysis, but especially sensitization to HLAs remains a major clinical obstacle to success. Kidney Transplantation in Sensitized Patients will assist in achieving optimal results in individual patients. It will be an important resource for everyone involved in the care of kidney transplant recipients.

Collecting and synthesizing all of the most recent literature on Kienböck's disease from around the world, this comprehensive text aims to provide a more dynamic, nuanced treatment algorithm for this enigmatic condition. Part I consolidates the basic science on Kienböck's and the lunate, including anatomy, pathology, biomechanics and etiology. Clinical assessment is covered in part II, including radiology, advanced imaging and arthroscopy. The natural history and progression of the condition in children, adults and the elderly is also presented. By far the largest section, part III describes the roles and methods of the various management strategies for Kienböck's, from minimally invasive techniques to arthroscopic and arthroplastic procedures. The final chapter draws from all of these concepts, establishes a new algorithm and provides a direction for the future. Written and edited by leaders in the field, and including supplemental video features for select chapters, Kienböck's Disease: Advances in Diagnosis and Treatment is a remarkable text that helps unlock this mysterious condition, and will be a valuable resource for hand and orthopedic surgeons, residents and trainees worldwide.

"In 1997, this groundbreaking book made a powerful entrance into the national conversation on race. In a media landscape dominated by racially biased images of welfare queens and crack babies, Killing the black body exposed America's systemic abuse of Black women's bodies. From slave masters' economic stake in bonded women's fertility to government programs that coerced thousands of poor Black women into being sterilized as late as the 1970s, these abuses pointed to the devaluation of Black motherhood--and the neglect of Black women's reproductive needs in mainstream feminist and civil rights agendas. Now, some two decades later, Killing the Black body remains as crucial as ever--a rallying cry for education, awareness, and action on extending reproductive justice to all women"--Page 4 of cover.

HTRF kinase assay development and methods in inhibitor characterization / Yong Jia, Mari Manuia, and Jose Juarez -- Application of eukaryotic elongation factor-2 kinase (eEF-2K) for cancer therapy : expression, purification, and high-throughput inhibitor screening / Clint D. J. Tavares ... [et al.] -- Recombinant kinase production and fragment screening by NMR spectroscopy / Byeonggu Han and Hee-Chul Ahn -- Bioluminescence methods for assaying kinases in quantitative high-throughput screening (qHTS) format applied to yes1 tyrosine kinase, glucokinase, and PI5P4Kα lipid kinase / Mindy I. Davis, Douglas S. Auld, and James Inglese -- Using bioluminescent kinase profiling strips to identify kinase inhibitor selectivity and promiscuity / Hicham Zegzouti, Jacquelyn Hennek, and Said A. Goueli -- Measuring activity of phosphoinositide lipid kinases using a bioluminescent ADP-detecting assay / Andrew W. Tai and Jolanta Vidugiriene -- High-throughput radiometric kinase assay / Krisna C. Duong-Ly and Jeffrey R. Peterson -- High-content assay to screen for modulators of EGFR function / Christophe Antczak and Hakim Djaballah -- Monitoring protein kinase expression and phosphorylation in cell lysates with antibody microarrays / Hong Zhang, Xiaoqing Shi, and Steven Pelech -- From enzyme to whole blood : sequential screening procedure for identification and evaluation of p38 MAPK inhibitors / Silke M. Bauer ... [e tal.] -- Genetically encoded fluorescent indicators to visualize protein phosphorylation in living cells / Moritoshi Sato and Yoshio Umezawa -- Characterization of an engineered Src kinase to study Src signaling and biology / Leanna R. Gentry .. [et al.] -- Screening one-bead-one-compound peptide libraries for optimal kinase substrates / Thi B. Trinh and Dehua Pei -- Determination of the substrate specificity of protein kinases with peptide micro- and macroarrays / Shenshen Lai ... [et al.] -- Rapid identification of protein kinase phosphorylation site motifs using combinatorial peptide libraries / Chad J. Miller and Benjamin E. Turk.

Includes risk management, enterprise resource planning, outsourcing, combinatorial synthesis and technology, functional foods, process automation, electronic chemicals, specialty silicones, mergers and acquisitions, nanoparticles, bioinformatics, ISO 14000, micron-scale chemical analysis, medical applications of biodegradable materials, product development, strategies, drug discovery strategies, chemistry of aging, single-site catalysis, custom manufacturing, and global chemical market analysis.

Anatomy, dimensions, and terminology -- Hypothermia, circulatory arrest, and cardiopulmonary bypass -- Myocardial management during cardiac surgery with cardiopulmonary bypass -- Anesthesia for cardiovascular surgery -- Postoperative care -- Generating knowledge from information, data, and analyses -- Stenotic arteriosclerotic coronary artery disease -- Left ventricular aneurysm -- Postinfarction ventricular septal defect -- Mitral regurgitation from ischemic heart disease -- Mitral valve disease with or without tricuspid valve disease -- Aortic valve disease -- Combined aortic and mitral valve disease with or without tricuspid valve disease -- Tricuspid valve disease -- Infective endocarditis -- Cardiac rhythm disturbance -- Cardiac trauma -- Cardiac tumor -- Hypertrophic obstructive cardiomyopathy -- Cardiomyopathy -- Cardiac transplantation -- Mechanical circulatory support -- Pericardial disease -- Acute traumatic aortic disruption -- Acute aortic dissection -- Chronic thoracic and thoracoabdominal aortic disease -- Diseases of the pulmonary arteries -- Acquired diseases of the systemic veins -- Congenital heart disease in the adult, Atrial septal defect and partial anomalous pulmonary venous connection -- Total anomalous pulmonary venous connection -- Cor triatriatum -- Unroofed coronary sinus syndrome -- Atrioventricular septal defect -- Ventricular septal defect -- Congenital sinus of valsalva aneurysms and aortico-left ventricular tunnel -- Patient ductus arteriosus -- Ventricular septal defect with pulmonary stenosis or atresia -- Pulmonary stenosis and intact ventricular septum -- Pulmonary atresia and intact ventricular septum -- Tricuspid atresia and single-ventricle physiology -- Ebstein anomaly -- Truncus arteriosus -- Aortopulmonary window -- Origin of the right or left pulmonary artery from the ascending aorta -- Congenital anomalies of the coronary arteries -- Congenital aortic stenosis -- Coarctation of the aorta and interrupted aortic arch -- Aortic atresia and other forms of hypoplastic left heart physiology -- Congenital mitral valve disease -- Vascular ring and sling -- Complete transposition of the great arteries -- Double outlet right ventricle -- Double outlet left ventricle -- Congenitally corrected transposition of the great arteries and other forms of atrioventricular discordant connection -- Double inlet ventricle and atretic atrioventricular valve -- Anatomically corrected malposition of the great arteries -- Atrial isomerism.

-- 1. Patient Safety, Quality, and Evidence-Based Medicine -- 2. Antenatal and Intrapartum Care of the High-Risk Infant -- 3. Resuscitation and Initial Stabilization -- 4. Physical Growth : Physical Examination of the Newborn Infant and the Physical Environment -- 5. Nutrition and Selected Disorders of the Gastrointestinal Tract -- 6. Genetics, Inborn Errors of Metabolism, and Newborn Screening -- 7. Care of the Parents -- 8. Developmental Care--Understanding and Applying the Science -- 9. Respiratory Problems -- 10. Assisted Ventilation --11. Glucose, Calcium, and Magnesium -- 12. Neonatal Hyperbilirubinemia -- 13. Infections in the Neonate -- 14. The Heart -- 15. The Kidney -- 16. Hematologic Problems -- 17. Neonatal Brain Disorders -- 18. Neonatal Imaging --19. The Outcome of Neonatal Intensive Care -- 20. Ethical Issues --

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

1. Bd., 1. T. Bauchschmerzen. 2. T. Körperschmerzen.

"Surgical skill does make a difference. Despite advances in implant design and the introduction of surgical navigation and robotics it remains clear that judgement, experience and insight still have no substitute"--Provided by publisher.

This book offers a comprehensive guide to knee arthroplasty that will assist in achieving excellent outcomes based on a sound understanding and technique. An introductory section on the primary knee arthroplasty that covers preoperative planning, surgical exposures, step by step approach to knee arthroplasty, unicondylar knee arthroplasty and radiological assessment are discussed in detail. The next section is devoted to topics pertaining to knee replacement in complex situations like bone defects, stiff knees, previous failed trauma and extra-articular deformities. A separate section has been dedicated to use of technology like Computer navigation and Robotics in TKA. An extensive section explains the causes and management of potential complications, including instability, infections, and periprosthetic fracture. Individual chapters focussing on multimodal pain management, deep vein thrombosis, rehabilitation and newer advances have been included .The surgical techniques appropriate for revision knee arthroplasty are described separately, and guidelines on how to deal with bone loss, instability, gap balancing, joint line restoration, and use of bulk allografts, hinges and condylar replacement prosthesis are provided. The authors are all respected experts from the United Kingdom, United States,India and Europe. The language of the book is easy to read, user friendly with colourful pictorial representation of relevant surgical steps. Case based discussions, surgical tips and pearls and summary has been added in each chapter. The references given at the end of each chapter would be useful for those doing research. This book should be of interest to practicing orthopaedic surgeon across the globe, beginner arthroplasty surgeons, postgraduate students of orthopaedics, DNB students and those preparing for board exams. This book will serve as a reference book for Master Arthroplasty surgeons as well as a compendium on Knee Arthroplasty.

This book provides detailed guidance on knee arthroscopy that reflects the very latest advances in this ever-changing field. Among the techniques covered are reconstruction of the anterior and posterior cruciate ligaments, meniscal repair and transplantation, cartilage repair by means of osteochondral allograft transplantation and autogenous osteochondral transfer, medial patellofemoral ligament reconstruction, and high tibial osteotomy. In each case, clear descriptions of technique are supported by a wealth of high-quality illustrations, with identification of potential pitfalls and how to avoid them. In addition, the latest knowledge is presented on anatomy and biomechanics. The book is written by recognized experts in sports injuries and knee disorders. It will serve as an up-to-date reference for the experienced knee surgeon and an ideal source of information for all who wish to broaden their knowledge of and improve their skills in knee arthroscopy, whether general orthopaedists, orthopaedic trainees, or sports medicine physicians.

This concise and handy book offers practical guidance to orthopedic surgeons and residents willing to master knee arthroscopy techniques in their daily practice. Based on scientific evidence but also mirroring expert know-how and best practices, it equips readers with essential information, tips and tricks to avoid and prevent intraoperative minor and major complications. Clearly and uniformly written, and featuring a wealth of intraoperative pictures, the book guides readers step-by-step through each of the presented arthroscopic procedures--from patient positioning, through meniscal suture approaches and hamstring grafting, to ACL, PCL and MPFL reconstructions. Covering all the basic and practical aspects this book is a must-read for residents and young orthopedic surgeons wanting to gain insights into this surgical technique and valuable tool for practicing orthopedists, sports physicians and physiotherapists with an interest in knee arthroscopy.

This book provides a complete overview of the various types of fractures around the knee. Each chapter addresses anatomical key features, surgical procedures, postoperative regimes and complication strategies. International knee experts discuss how to improve nailing techniques as well as pearls and pitfalls for each type of knee fracture. Current clinical outcomes are included throughout and the authors recommend their preferred therapeutic approach and salvage measures if required. Knee Fractures is an essential, go-to resource for orthopaedic surgeons dealing with the total spectrum of simple and complex knee fractures in daily clinical practice.

This booklet, in A to Z format, is a succinct but wide-ranging guide to the use of MRI for investigations of the knee joint. It provides easily retrievable answers to the questions that arise frequently during daily radiological practice. All relevant injuries and disorders are covered, typically with brief descriptions of pathological and clinical characteristics, guidance on selection of imaging technique, identification of potential diagnostic clues, and highlighting of useful tips and tricks. In addition, practical, state-of-the-art information is provided on other aspects of relevance. Characteristic images are included as necessary. Knee Imaging, published within the series A-Z Notes in Radiological Practice and Reporting, will be of value for both residents and general radiologists. Beyond assisting in MR reporting, it will help examination candidates in their preparation.

This book presents up-to-date knowledge on all aspects of total knee joint arthroplasty (TKA). It opens by considering indications for TKA and implant selection, covering basic science, design, and prosthetic materials. The basic and advanced operative procedures, along with theoretical background, are then described in detail for both primary and revision surgery. The operative techniques for TKA in specific and complex conditions are included. Complications of TKA and their treatment are also discussed, and clear guidance is provided on postoperative management and patient education. The author introduces his personal surgical tips and opinions on controversial issues based on his experience of TKA in some 6,000 cases. Numerous helpful illustrations and radiographs from the author's caseload are presented to assist readers in carrying out the described procedures.

Knee ligament injuries are very common and are frequently sports related, although they may arise from trauma experienced during everyday activities. This book provides in-depth descriptions of the extra articular surgical techniques that may be employed when performing ligament reconstruction in patients with injuries involving the posterolateral and posteromedial corners of the knee. It is intended as a practical, how to manual that will be of value for both the trainee and the more experienced surgeon. Many of the techniques relate to the central pivot of the knee, i.e. the anterior and posterior cruciate ligaments. For each technique, indications, presurgical planning, postsurgical follow-up and complications are discussed in addition to the surgical details. Numerous tips and pearls are provided and the techniques are clearly depicted in informative high-quality illustrations.

This book provides a concise and accessible resource for evaluating, diagnosing, and managing common knee disorders. The chapters are presented in a clear, and easily understood style so that practitioners can readily apply the information in their day-to-day clinical practice. The Knee Made Easy opens with discussion of the anatomy, biomechanics, clinical examination and radiological imaging of the knee, followed by commonly encountered clinical symptoms and conditions of the knee. Each clinical condition is demonstrated with the background, presentation, investigations, and treatment options. Medical students, generalist doctors, junior orthopaedic doctors, and physiotherapists will find this book to be an essential go-to guide for effectively treating the most common knee disorders and improving patients' care.

An indispensable step-by-step guide on a full spectrum of open and arthroscopic knee procedures Knee disorders are among the most common musculoskeletal conditions and, as such, constitute four of the top seven orthopaedic procedures. Currently, 720,000 knee replacements are performed annually in the US, with a projected 3.4 million surgeries by 2030. Knee Surgery: Tricks of the Trade edited by renowned knee surgeons and educators James P. Stannard, Andrew Schmidt, and Mauricio Kfuri features contributions from an impressive cadre of distinguished colleagues. The reader-friendly book fills a g

This book discusses the full range of current applications of computer-assisted surgery and robotics in the field of knee surgery, and also considers potential future applications. The impact of computer-assisted surgery on a wide range of surgical procedures is clearly explained. Procedures considered include total knee arthroplasty, unicompartmental knee arthroplasty, cruciate ligament reconstruction, patellofemoral arthroplasty, and revision surgery. In each case, technical aspects are thoroughly addressed in a readily understandable manner. Knee Surgery Using Computer-Assisted Surgery and Robotics will be an ideal guide to this exciting field for both novice and more experienced surgeons who treat knee injuries and disorders.

"An exquisitely written, expertly reported memoir and expose; of modern medicine that leads the way to more humane, less invasive end-of-life care based on the author's acclaimed New York Times Magazine piece. This is the story of one daughter's struggle to allow her parents the peaceful, natural deaths they wanted and to investigate the larger forces in medicine that stood in the way. When doctors refused to disable the pacemaker that caused her eighty-four-year-old father's heart to outlive his brain, Katy Butler, an award-winning science writer, embarked on a quest to understand why modern medicine was depriving him of a humane, timely death. After his lingering death, Katy's mother, nearly broken by years of nonstop caregiving, defied her doctors, refused open-heart surgery, and insisted on facing death the old-fashioned way: bravely, lucidly, and head on. Against this backdrop of familial love, wrenching moral choices, and redemption, Knocking on Heaven's Door celebrates the inventors of the 1950s who cobbled together lifesaving machines like the pacemaker and it exposes the tangled marriage of technology, medicine, and commerce that gave us a modern way of death: more painful, expensive, and prolonged than ever before. Caring for declining parents is a reality facing millions who may someday tell a doctor: "Let my parent go." A riveting exploration of the forgotten art of dying, Knocking on Heaven's Door empowers readers to create new rites of passage to the "Good Deaths" our ancestors so prized. Like Jessica Mitford's The American Way of Death and How We Die by Sherwin Nuland, it is sure to cause controversy and open minds"-- Provided by publisher.