Books
- The R primer. Second edition. — Real-world applications in cognitive neuroscience (171)
- Reality therapy and self-evaluation : the key to client change — Renal cell carcinoma-- molecular targets and clinical applications. Third edition. [3rd ed.] (171)
- Renal denervation : a new approach to treatment of resistant hypertension — Rhino-orbito-cerebral mucormycosis (171)
- Rhinology and anterior skull base surgery : a case-based approach — Ryan's Retina. Seventh edition. (168)
- DigitalRobert E. Wubbolding.Contents:
Human motivation: "In general why do people do what they do?"
Human motivation: "Specifically why do people do what they do?"
The counseling environment: "How do I set the stage for self-evaluation?"
What is the WDEP system?
Career concerns
Cross-cultural applications
Dealing with loss, posttraumatic stress, self-injury, conflict, and anger
Reality threapy FAQs
Conclusion.Digital Access Wiley 2017 - DigitalPaul Cerrato, John Halamka.Summary: "Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.Provides drawings and flow charts to help readers visualize the breadth and depth of precision medicine includes sidebars with more details on specific topics for a complementary, deeper understanding of text. Uses case studies to turn abstract concepts into flesh and blood examples of how personalized medicine benefits patients"-- Provided by publisher.
Contents:
Population Medicine Versus Personalized Medicine
Precision Medicine Initiatives and Programs
The Role of Genomics
Small Data, Big Data, and Data Analytics
How Mobile Technology and EHRs Can Personalize Healthcare
i2b2, SHRINE, Clinical Query, and Other Research Tools
Barriers and Limitations
Interoperability and Personalized Patient Care
Privacy and Security
Patient and Consumer Engagement.Digital Access ScienceDirect 2018 - DigitalDaniel Krawczyk.Summary: Reasoning: The Neuroscience of How We Think is a comprehensive guide to the core topics related to a thorough understanding of reasoning. It presents the current knowledge of the subject in a unified, complete manner, ranging from animal studies, to applied situations, and is the only book available that presents a sustained focus on the neurobiological processes behind reasoning throughout all chapters, while also synthesizing research from animal behavior, cognitive psychology, development, and philosophy for a truly multidisciplinary approach. The book considers historical perspectives, state-of-the-art research methods, and future directions in emerging technology and cognitive enhancement. Written by an expert in the field, this book provides a coherent and structured narrative appropriate for students in need of an introduction to the topic of reasoning as well as researchers seeking well-rounded foundational content. It is essential reading for neuroscientists, cognitive scientists, neuropsychologists and others interested in the neural mechanisms behind thinking, reasoning and higher cognition.
Contents:
Introduction to Reasoning
The History of Reasoning Research
The Neuroscience of Reasoning
Comparative Reasoning: A Cross-Species Perspective
Reasoning Origins: Human Development During Childhood
Reasoning Over the Lifespan
Disorders of Reasoning
Reasoning About Contingencies, Correlations, and Causes
Deduction and Induction
Analogical Reasoning
Decision Making and Abdutive Reasoning
Social Cognition: Reasoning With Others
Future Directions in Reasoning: Emerging Technology and Cognitive Enhancement.Digital Access ScienceDirect 2018 - DigitalLouise Cummings.Summary: This book argues that in order to be truly effective, public health must embrace a group of reasoning strategies that have traditionally been characterized as informal fallacies. It will be demonstrated that these strategies can facilitate judgements about complex public health issues in contexts of uncertainty. The book explains how scientists and lay people routinely resort to the use of these strategies during consideration of public health problems. Although these strategies are not deductively valid, they are nevertheless rationally warranted procedures. Public health professionals must have a sound understanding of these cognitive strategies in order to engage the public and achieve their public health goals. The book draws upon public health issues as wide ranging as infectious diseases, food safety and the potential impact on human health of new technologies. It examines reasoning in the context of these issues within a large-scale, questionnaire-based survey of nearly 900 members of the public in the UK. In addition, several philosophical themes run throughout the book, including the nature of uncertainty, scientific knowledge and inquiry. The complexity of many public health problems demands an approach to reasoning that cannot be accommodated satisfactorily within a general thinking skills framework. This book shows that by developing an awareness of these reasoning strategies, scientists and members of the public can have a more productive engagement with public health problems.
Contents:
Chapter One: The Challenge for Public Health
Chapter Two: Philosophy and Public Health
Chapter Three: Argument from Ignorance
Chapter Four: Argument from Authority
Chapter Five: Argument from Analogy
Chapter Six: Circular Argument
Chapter Seven: Fallacies in Public Health
Chapter Eight: Theory of Public Health Reasoning
Bibliography
Index.Digital Access Springer 2015 - DigitalAjar Nath Yadav, Shashank Mishra, Sangram Singh, Arti Gupta, editors.Summary: White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.
Contents:
Preface
Biodiversity of Fungi from Extreme Habitats and Its Industrial Applications
Rhizospheric Fungi Isolated from Different Plants and Potential Applications in Diverse Sectors
Endophytic Fungi from Different Niches with Potential Industrial Importance
Marine Fungal White Biotechnology
Aspergillus Biodiversity, Ecological Significance, and Industrial Applications
Fusarium Biodiversity, Ecological Significance, and Industrial Applications
Penicillium Biodiversity, Ecological Significance, and Industrial Applications
Trichoderma Biodiversity, Ecological Significance, and Industrial Applications
Thermostable Enzymes from Fungi Isolated from Hot Springs and Its Applications
Cold Active Enzymes from Psychrophilic Fungi and Its Applications
Industrially Important Enzymes from White-Rot Fungi or Filamentous Fungi
Fungal Enzymes for the Textile Industry
Fungal Laccase
Fermentation Process for Production of Fungal Cellulases
Fungal Lipases
Fungal Community and Eco-Friendly Bioresources for Novel Secondary Metabolites
Agriculturally Important Fungi
Fungal White Biotechnology in Biosurfactants
Synthetic Biology and a Novel Approach for Pharmaceutically Important Compounds
Global Scenario of Fungal White Biotechnology
Appendixes
Index - Digitaledited by Ajar Nath Yadav, Sangram Singh, Shashank Mishra, Arti Gupta.Summary: White biotechnology is industrial biotechnology dealing with various biotech products through applications of microbes. The main application of white biotechnology is commercial production of various useful organic substances, such as acetic acid, citric acid, acetone, glycerine, etc., and antibiotics like penicillin, streptomycin, mitomycin, etc., and value added product through the use of microorganisms especially fungi and bacteria. The value-added products included bioactive compounds, secondary metabolites, pigments and industrially important enzymes for potential applications in agriculture, pharmaceuticals, medicine and allied sectors for human welfare. In the 21st century, techniques were developed to harness fungi to protect human health (through antibiotics, antimicrobial, immunosuppressive agents, value-added products etc.), which led to industrial scale production of enzymes, alkaloids, detergents, acids, biosurfactants. The first large-scale industrial applications of modern biotechnology have been made in the areas of food and animal feed production (agricultural/green biotechnology) and pharmaceuticals (medical/red biotechnology). In contrast, the production of bio-active compounds through fermentation or enzymatic conversion is known industrial or white biotechnology. The beneficial fungal strains may play important role in agriculture, industry and the medical sectors. The beneficial fungi play a significance role in plant growth promotion, and soil fertility using both, direct (solubilization of phosphorus, potassium and zinc; production of indole acetic acid, gibberellic acid, cytokinin and siderophores) and indirect (production of hydrolytic enzymes, siderophores, ammonia, hydrogen cyanides and antibiotics) mechanisms of plant growth promotion for sustainable agriculture. The fungal strains and their products (enzymes, bio-active compounds and secondary metabolites) are very useful for industry. The discovery of antibiotics is a milestone in the development of white biotechnology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high valued nutraceuticals and pharmaceutical products. The fungal strains and bio-active compounds also play important role in the environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.
Contents:
Foreword
Preface
Agriculturally and Industrially Important Fungi: Current Developments and Potential Biotechnological Applications
Fungal Phytases: Biotechnological Applications in Food and Feed Industries
Fungal Probiotics: Opportunity, Challenge and Prospects
Fungal White Biotechnology Applications for Food Security: Opportunities and Challenges
Volatile Organic Compounds from Endophytic Fungi
Natural Value-Added Compounds form Fungal Communities
Natural Product Synthesis by Fungi: Recent Trends and Future Prospect
Fungal Derived Natural Product: Synthesis, Function, and Applications
Fungal Community for Novel Secondary Metabolites
Industrially Important Pigments from Different Groups of Fungi
Bioactive Compounds of Endophytic Fungi associated with Medicinal Plants
Extracellular Carbohydrate-Active Enzymes of Trichoderma and their Role in the Bioconversion of Nonedible Biomass to Biofuel
Fungal Biofuels: Innovative Approaches
Lignocellulosic biomass to fungal Single Cell Oils: A radical bioconversion towards establishing a prospective resource
Recent Advancement and the Way Forward for Cordyceps
Synthetic Biology: A Novel Approach for Pharmaceutically Important Compounds
Index.- - DigitalAjar Nath Yadav, Sangram Singh, Shashank Mishra, Arti Gupta, editors.Summary: Over the last decade considerable progress has been made in white biotechnology research and further major scientific and technological breakthroughs are expected in the future. The first large-scale industrial applications of modern biotechnology have been in the areas of food and animal feed production (agricultural/green biotechnology) and in pharmaceuticals (medical/red biotechnology). In contrast, the productions of bio-active compounds through fermentation or enzymatic conversion are known as industrial or white biotchnology. The fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature salinity and pH);and associated with plants (Epiphytic, Endophytic and Rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and its product (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.
Contents:
Intro; Foreword; Foreword; Preface; Contents;
Chapter 1: Secretomics of Wood-Degrading Fungi and Anaerobic Rumen Fungi Associated with Biodegradation of Recalcitrant Plant Biomass; 1.1 Introduction; 1.2 Degradation and Depolymerization of Plant Biomass; 1.3 Secretomics and Mechanism of Lignocellulose Biodegradation; 1.4 Wood-Degrading Fungi; 1.4.1 Secretomes of White Rot Fungi (WRF); 1.4.2 Secretome of Brown Rot Fungi (BRF); 1.5 Secretome of Anaerobic Rumen Fungi (ARF); 1.6 Conclusion; References;
Chapter 2: Bioremediation: New Prospects for Environmental Cleaning by Fungal Enzymes 2.1 Introduction2.2 Bioremediation; 2.2.1 Types of Bioremediation; 2.2.1.1 Biostimulation; 2.2.1.2 Bioattenuation; 2.2.1.3 Bioaugmentation; 2.2.1.4 Bioventing; 2.2.1.5 Biopiles; 2.2.2 Limitations of Bioremediation; 2.3 Fungi as Bioremediator; 2.3.1 White-Rot Fungi; 2.3.2 Marine Fungi; 2.3.3 Extremophilic Fungi; 2.3.4 Symbiotic Fungi with Plants; 2.4 Fungal Enzymes in Bioremediation; 2.4.1 Enzymological Background; 2.4.1.1 Oxidoreductases; 2.4.1.2 Laccases; 2.4.1.3 Catalase; 2.4.1.4 Peroxidases; 2.4.1.4.1 Lignin Peroxidases; 2.4.1.4.2 Manganese Peroxidases; 2.4.1.4.3 Versatile Peroxidases 2.4.2 Advantages of Enzymatic Bioremediation2.4.3 Disadvantages of Enzymes; 2.4.4 Scope of Enzymatic Bioremediation; 2.5 Conclusion and Future Prospects; References;
Chapter 3: Genetic Diversity of Methylotrophic Yeast and Their Impact on Environments; 3.1 Introduction; 3.2 Genetic Diversity of Methylotrophic Yeast; 3.3 Genetic Regulation in Yeast Methylotrophy; 3.4 Methylotrophic Yeast and Impact to the Environments; 3.5 Conclusion and Future Prospects; References;
Chapter 4: White Rot Fungi and Their Enzymes for the Treatment of Industrial Dye Effluents; 4.1 Introduction; 4.2 Textile Dyes 4.3 Dyes Used in India4.4 Description of Dyeing Process and Sources of Effluent Generation; 4.4.1 Characterization of the Raw Effluents; 4.5 Enzymes of White Rot Fungi; 4.5.1 Lignin Peroxidase (LiP); 4.5.2 Manganese Peroxidase (MnP); 4.5.3 Laccase; 4.6 Factors Influencing Enzyme Production and Dye Degradation; 4.6.1 Effect of Inducers on Enzyme Production; 4.6.2 Effect of Nitrogen Source; 4.6.3 Effect of Carbon Source; 4.6.4 Influence of pH and Temperature; 4.6.5 Concentration of Dye; 4.7 White Rot Fungi and Decolouration; 4.8 White Rot Fungi and Decolourization of Industrial Dye Effluents 4.9 Conclusion and Future ProspectsReferences;
Chapter 5: Pleurotus ostreatus: A Biofactory for Lignin-Degrading Enzymes of Diverse Industrial Applications; 5.1 Introduction; 5.2 Understanding Lignin Structure; 5.2.1 Lignocellulose Processing and Industrial Applications; 5.2.2 Lignin Degradation; 5.3 Laccase (EC 1.1.2.2); 5.3.1 Laccases Structure and Mechanism of Reaction; 5.3.2 Laccase Production and Bioprocessing; 5.3.2.1 Media Composition and Cultivation Conditions; 5.3.2.2 Cultivation Process and Purification; 5.3.3 Applications of LaccaseDigital Access Springer 2019 - DigitalPrakash Kumar Sarangi, Sonil Nanda and Pravakar Mohanty, editors.Summary: The concerns relating to global warming, climate change, and increasing energy demands have led to significant research towards the development of alternative energy to substitute the fossil energy sources. Biomass-based energy or biofuels are highly promising due to many perceptible environmental and socio-economic advantages. Cutting-edge academic research and advanced industrial product development have created tremendous scope for the implementation of biofuels at a global scale to reduce the greenhouse gas emissions and supplement the escalating energy demands. The prime focus of this book is to provide an overview of the different technologies utilized to harness the chemical energy from plant-based non-edible biomass and other organic wastes in the form of solid, liquid, and gaseous biofuels. The opportunities and challenges of different biomass conversion technologies, especially biomass-to-liquid, biomass-to-gas and gas-to-liquid routes, as well as biomass pretreatments, densification, anaerobic digestion, reforming, transesterification, supercritical fluid extraction, microalgal carbon sequestration, life-cycle assessment and techno-economic analysis have been comprehensively discussed in this book. This book is an amalgamation of fifteen different chapters each with distinctive investigations and a collective focus relating to the transition from fossil fuels towards carbon-neutral biofuels. This book serves as a benchmark for academic and industrial researchers involved in exploring the true potentials of plant residues and waste organic matter to produce alternative renewable fuels. To realize the real promises of bioenergy, this book attempts to assess the biorefining approaches, biofuel production and application, and environmental sustainability.
Contents:
Intro; Preface; Contents; Contributors; About the Editors;
1: A Broad Introduction to First-, Second-, and Third-Generation Biofuels; 1.1 Introduction; 1.2 First-, Second-, and Third-Generation Biomass Sources; 1.3 Bioethanol; 1.4 Biobutanol; 1.5 Bio-oil; 1.6 Algal Oil; 1.7 Biodiesel; 1.8 Hydrogen; 1.9 Biomethane; 1.10 Aviation Fuel; 1.11 Conclusions; References;
2: Densification of Agricultural Wastes and Forest Residues: A Review on Influential Parameters and Treatments; 2.1 Introduction; 2.2 Effects of Moisture Content; 2.3 Effects of Pelletization Temperature. 2.4 Effects of Pelletization Pressure (Applied Force)2.5 Effects of Particle Size; 2.6 Effects of Binders and Extractives; 2.7 Biomass Pre-treatments; 2.7.1 Steam Explosion; 2.7.2 Biomass Torrefaction; 2.8 Pellet Post-treatments; 2.8.1 Pellet Coating; 2.8.2 Pellet Torrefaction; 2.9 General Risk Evaluation for Handling and Storage of Biomass Pellets; 2.9.1 Dust Formation; 2.9.2 Self-Ignition and Self-Heating; 2.9.3 Formation of Off-Gases; 2.10 Conclusions; References;
3: An Overview on the Application of Ligninolytic Microorganisms and Enzymes for Pretreatment of Lignocellulosic Biomass. 3.1 Introduction3.2 Composition of Biomass; 3.3 Biological Pretreatment of Biomass: An Overview; 3.4 Application of Lignin-Degrading Microorganisms for Pretreatment of Biomass; 3.5 Application of Ligninolytic Enzymes for Pretreatment of Biomass; 3.6 Factors Affecting Biological Pretreatment of Biomass; 3.7 Conclusions; References;
4: Role of Natural Deep Eutectic Solvents (NADES) in the Pretreatment of Lignocellulosic Biomass for an Integrated Biorefinery ... ; 4.1 Introduction; 4.2 Lignocellulosic Feedstocks; 4.3 Biomass Pretreatment Processes; 4.4 Biological Pretreatment. 4.11.7 Bioethanol Production4.11.8 Carbon Dioxide Sequestration; 4.11.9 Chemical Extraction; 4.12 Technical Assessment of NADES; 4.13 Future Perspective; 4.14 Conclusions; References;
5: Recent Developments and Challenges of Acetone-Butanol-Ethanol Fermentation; 5.1 Introduction; 5.2 Acetone-Butanol-Ethanol (ABE) Fermentation Process; 5.3 Challenges and Possible Outcomes in the ABE Fermentation; 5.4 Conclusions; References;
6: Current Advancements, Prospects and Challenges in Biomethanation; 6.1 Introduction; 6.2 Methanotrophs; 6.3 Bioremediation via Methanotrophy. 4.5 Physical Pretreatment4.6 Physicochemical Pretreatment; 4.7 Chemical Pretreatment; 4.8 Natural Deep Eutectic Solvents (NADES): Synthesis and Mechanism; 4.9 Types of NADES Reagents; 4.9.1 Hydrophilic; 4.9.2 Hydrophobic; 4.10 Physicochemical Properties of NADES; 4.10.1 Structure; 4.10.2 Viscosity; 4.10.3 Density; 4.10.4 Conductivity; 4.10.5 Thermal Properties; 4.10.6 Polarity; 4.11 Functional Properties of NADES; 4.11.1 Specificity; 4.11.2 Toxicity and Biodegradability; 4.11.3 Recyclability; 4.11.4 Biocatalysis; 4.11.5 Biorefinery and Bioprocessing; 4.11.6 Production of Reducing Sugars. - DigitalGuoyao Wu, editor.Contents:
Chapter 1: Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health
Chapter 2: Insights into the Regulation of Implantation and Placentation in Humans, Rodents, Sheep, and Pigs
Chapter 3: A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses
Chapter 4: Nutritional Regulation of Embryonic Survival, Growth and Development
Chapter 5: Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals
Chapter 6: Nutritional and Physiological Regulation of Water Transport in the Conceptus
Chapter 7: Amino Acids in Microbial Metabolism and Function
Chapter 8: Potential Replacements for Antibiotic Growth Promoters in Poultry: Interactions at the Gut Level and their Impact on Host Immunity
Chapter 9: Microbiomes in the Intestine of Developing Pigs: Implications for Nutrition and Health
Chapter 10: L-Arginine Nutrition and Metabolism in Ruminants
Chapter 11: Hepatic Glucose Metabolism and Its Disorders in Fish
Chapter 12: Protein-Sourced Feedstuffs for Aquatic Animals
Chapter 13: Functional Molecules of Intestinal Mucosal Products in Animal Nutrition and Health
Chapter 14: Use of Genome Editing Techniques to Produce Transgenic Farm Animals
Chapter 15: Cows as Bioreactors for the Production of Nutritionally and Biomedically Significant Proteins
Chapter 16: Use of Agriculturally Important Animals as Models in Biomedical Research
Chapter 17: Pigs (Sus Scrofa) in Biomedical Research.Digital Access Springer 2022 - DigitalYashpal Singh Malik, Raj Kumar Singh, Mahendra Pal Yadav, editors.Summary: This book discusses the prominence and implication of the viral diseases that are a major threat to animals around the globe. A number of these diseases have also shown links with human populations, which has implications for public health. This book offers detailed and up-to-date information on viral diseases in livestock and poultry that were and/or are still a problem. Including cutting-edge developments, it also highlights several landmark contributions in the field of virology from India. Additionally, the book features tables and figures showing important clinical data and recommendations, with references for further information. It also explores the economic impact of viral diseases for farmers and the livestock industry, providing several examples. Further, it presents the latest information on viral diseases in global context, with a focus on state-of-art, molecular tools for the development of diagnostics, prophylactics and therapeutics. Lastly, the book also describes the challenges posed by the emerging and transboundary viral infections and our preparedness to counter them.
- DigitalByung-Jun Yoon, Xiaoning Qian, editors.Springer Nature eBook.Summary: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights.
Contents:
Chapter 1: Global Alignment of PPI Networks
Chapter 2: Integrated Network-Based Computational Analysis for Drug Development
Chapter 3: Effective Random Walk Models for Comparative Network Analysis
Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment
Chapter 5: Network Propagation for the Analysis of Multi_Omics Data
Chapter 6: Motifs in Biological Networks
Chapter 7: Bio Fabric Visualization of Network Alignments
Chapter 8: Module Identification of Biological Networks via Graph Partition
Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations. - Digitaleditor Anna N. Bukiya.Summary: This book comprehensively covers modern topics in cannabinoid research and medicinal use. The chapters span topics from the role of endocannabinoid system in embryonic and fetal development to cardiovascular disease, cancer, drug abuse and cutting-edge therapeutic applications. The content is presented at different levels of resolution. First, following an introduction into cannabinoid system components, readers are immersed into cannabinoid chemistry with a systematic overview of structural data that describe cannabinoid complexes with proteins at the atomic resolution. The remaining chapters capitalize on these interactions. They describe the cannabinoid role during embryonic, fetal, and adolescent development, in the cardiovascular system, cancer progression, and development of alcohol use disorders. Next, the topic of illicit marijuana use and abuse is discussed with an emphasis on possible genetic factors that may play a role in dependence. The book concludes with the most integrative level. It covers promising pharmacological leads in medicinal use of cannabimimetics to treat pain, epilepsy, and neurodegenerative disorders. The book brings together contributions from researchers and clinical scientists at different career stages. While some chapters are presented by well-recognized names, others are written by young investigators emerging in the field of cannabinoid research and medicinal use. The book will be of interest to audiences from biological/chemical disciplines with keen interest in the physiological effects of cannabis. The text quickly introduces the reader to the multi-faceted roles played by endogenous, phyto- and synthetic cannabinoids in health, disease, and modern drug development. Reader will gain insight into the current state of popular but still controversial topic of cannabinoids.
Contents:
Prelims
Introduction
Endocannabinoid System Components: Overview and Tissue Distribution
Physiology of the Endocannabinoid System During Development
Cannabinoid Interactions With Proteins: Insights From Structural Studies
Cannabinoid Signaling in Cancer
Cannabinoids and Cardiovascular System
Endocannabinoid System and Alcohol Abuse Disorders
Genetic factors in Cannabinoid Use and Dependence
Pharmacology of Medical Cannabis
Index. - PrintGranville-Grossman, Kenneth.
- Digitalvolume editor, Hidetomo Nakamoto ; co-editors, Kosaku Nitta, Ken Tsuchiya, Hirokazu Okada, Hajime Hasegawa.Digital Access Karger 2018
- DigitalSumita Mehta, Bindiya Gupta, editors.Summary: This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.
Contents:
Intro
Preface
Contents
About the Editors
Contributors
Part I: Trends and Etiology of Endometrial Cancer
1: Changing Trends in the Epidemiology of Endometrial Cancer
1.1 Introduction
1.2 Type I and II Carcinomas
1.2.1 Pathophysiologic and Molecular Distinctions
1.2.2 Type II-Specific Epidemiologic Factors
1.3 Age
1.4 Race/Ethnicity
1.4.1 Blacks
1.4.2 Hispanics
1.4.3 Asians/Pacific Islanders
1.4.4 American Indians/Alaska Natives
1.4.5 Global Trends
1.5 Endogenous Estrogen Exposure
1.5.1 Pathophysiologic Mechanisms of Disease 1.5.2 Chronic Anovulation
1.5.3 Obesity
1.5.4 Early Menarche and Late Menopause
1.5.5 Estrogen-Secreting Tumors
1.6 Exogenous Estrogen Exposure
1.6.1 Unopposed Estrogen Therapy
1.6.2 Postmenopausal Hormone Replacement Therapy
1.6.3 Tamoxifen, Other SERMs, and Aromatase Inhibitors
1.7 Genetic Syndromes
1.7.1 Family History
1.7.2 Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
1.7.3 Cowden Syndrome
1.7.4 BRCA1 and BRCA2 Mutations
1.8 Fertility-Associated Factors
1.8.1 Nulliparity and Infertility
1.8.2 Breastfeeding 1.8.3 Contraceptives
1.8.4 Tubal Ligation
1.9 Other Associated Factors
1.9.1 Diet and Phytoestrogens
1.9.2 Ultraviolet Radiation, Calcium, and Vitamin D
1.9.3 Exercise
1.9.4 Diabetes and Hypertension
1.9.5 Cigarette Smoking
1.9.6 Alcohol
1.9.7 Coffee and Tea
1.9.8 Aspirin
1.10 Summary
References
2: Cytogenetic Mechanisms in Endometrial Cancer
2.1 Introduction
2.2 Classification of EC
2.2.1 Clinicopathological Classification
2.2.2 Genetic Classification
2.3 Role of Estrogen 2.3.1 Imbalance Between Estrogen-Induced Endometrial Proliferation and Mismatch Repair System
2.3.2 Dysregulation of Different Genetic Factors by Estrogen
2.4 Mechanisms Involved in Genesis of EC at Cytogenetic Level
2.4.1 Epigenetics
2.4.2 Abnormal Mismatch Repair (MMR) System
2.4.3 Gene Mutation
2.4.3.1 Tumor Suppressor Genes
2.4.3.2 Oncogenes
2.4.4 MicroRNA
2.5 Cytogenetic Basis of Different Characteristics of EC
2.5.1 Myometrial Invasion
2.5.2 Apoptosis Resistance
2.5.3 Resistance to Ionizing Radiation Treatment
2.6 Conclusion
References 3: Endometrial Precancers: Diagnosis and Management
3.1 Introduction
3.2 Etiology
3.3 Classification
3.3.1 Endometrial Intraepithelial Neoplasia
3.4 Comparison Between WHO and EIN Classification
3.5 Clinical Features
3.6 Diagnosis
3.6.1 Ultrasound
3.6.2 Office Endometrial Biopsy
3.6.3 Hysteroscopy and Targeted Biopsy
3.6.4 CT/MRI/Biomarkers
3.7 Management
3.7.1 Observation
3.7.2 Medical Management
3.7.2.1 Progestin
3.7.2.2 Clomiphene or Aromatase Inhibitors
3.7.2.3 Metformin
3.7.2.4 GnRH Agonist
3.7.2.5 Danazol
3.7.2.6 Genistein. - DigitalLaura Calzà, Luigi Aloe, Luciana Giardino, editors.Summary: More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Contents:
Part I. Basic Science
Nerve Growth Factor, The First Molecule of the Neurotrophin Family
The First and Last Time I Met Rita Levi-Montalcini: From the Insect Neurotrophic Factor to the Nerve Growth Factor Clinical Application
NGF Signalling in Endosomes
The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery
Part II. Development and Regeneration
NGF and Endogenous Regeneration: From Embryology Toward Therapies
The Versatile Roles of Nerve Growth Factor in Neuronal Attraction, Odontoblast Differentiation and Mineral Deposition in Human Teeth
An Overview of Adult Neurogenesis
Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis
Part III. Alzheimer and Central Nervous System
Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology
NGF and Amyloid Precursor Protein in Alzheimer’s Disease: From Molecular Players to Neuronal Circuits
A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer´s Disease
NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimers Disease?
Part IV. Complex Behaviors
When Nerve Growth Factor Met Behavior
Crosstalk of BDNF and GDNF in Spinal Substantia Gelatinosa (Lamina II): Focus on Circuitry
PART V. Clinical Medicine
BDNF Gene as a Precision Skill of Obesity Management
The Science of Love: State of the Art
NGF and Retinitis Pigmentosa: Structural and Molecular Studies
NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders
Part VI. Veterinary Medicine
Nerve Growth Factor (NGF) and Animal Reproduction
Neurotrophins in the Brain of Teleost Fish: The State of the Art. - PrintApley, A. Graham; McKibbin, B.
- PrintWilkinson, A. W.
- Digitaledited by Anders Björklund, M. Angela Cenci.Contents:
Intro
Recent Advances in Parkinson's Disease
Copyright
Contributors
Contents
Preface: The evolving scenario of Parkinson's research
Part I: Basic Science
Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease
1. Introduction
2. Establishment of iPSC technology and methods of differentiation into DAns
2.1. Establishment of induced pluripotent stem cells
2.2. Differentiation into DAns
3. iPSC-derived neurons for disease modeling
3.1. Endoplasmic reticulum stress
3.2. Protein trafficking and degradation deficits 3.3. Mitochondrial defects and oxidative stress
3.4. Alterations in calcium homeostasis
4. iPSC-derived glial cells for disease modeling
5. Co-culture systems, 3D cultures and organoids for disease modeling
6. iPSC-derived neurons for cell-based treatments
7. Limitations of iPSC-based models
8. Future applications
9. Conclusions
Acknowledgments
References
Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal
1. Introduction
2. Models in different species
3. The importance of nigrostriatal dopaminergic degeneration 4.3. Tertiary and quaternary structure of aSyn
4.4. The effect of PD-associated mutations in aSyn
4.5. Post-translational modifications
5. Alpha-synuclein pathology in the synapse
6. aSyn pathology in mitochondria
7. aSyn pathology in the ER-Golgi compartments
7.1. Degradation and clearance of aSyn
7.2. aSyn pathology and the cytoskeleton
7.3. Effects of aSyn in the nucleus
8. Spreading of aSyn pathology
9. The interplay between aSyn and the microbiome
10. Inflammation
11. Conclusions and outlook
Acknowledgments
ReferencesDigital Access ScienceDirect 2020 - Digital/PrintDigital Access
- Digital/Printedited by Maria Diakonova, PhD.Summary: Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
Contents:
Prolactin in adipose tissue: regulation and functions
Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis
The many faces of prolactin in breast cancer
Regulation of blood vessels by prolactin and vasoinhibins
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion
Plasticity of the prolactin Axis: mechanisms underlying regulation of output in female mice
Role of Src family kinases in prolactin signaling
Prolactin-Induced Protein in Breast Cancer
Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse
Prolactin-induced prostate tumorigenesis
Prolactin in inflammatory response
A positive feedback loop between prolactin and STAT 5 promotes angiogenesis
Index. - DigitalChristos G. Athanassiou, Frank H. Arthur, editors.Summary: "This book aims to assess, evaluate and critically analyze the methods that are currently available for a judicious pest management in durable food. It presents and analyzes a vast amount of methods that are already in use in "real world" industrial applications. After the phase-out of methyl bromide, but also the withdrawal of several insecticides and the continuously updated food safety regulations, there is a significant knowledge gap on the use of risk-reduced, ecologically-compatible control methods that can be used with success against stored-product insect species and related arthropods. The importance of integrated pest management (IPM) is growing, but the concept as practiced for stored products might differ from IPM as historically developed for field crops. This book discusses a wide variety of control strategies used for stored product management and describes some of the IPM components. The editors included chemical and non-chemical methods, as both are essential in IPM. They set the scene for more information regarding emerging issues in stored product protection, such as emerging, alien and invasive species as threats for global food security, as well as the importance of stored-product arthropods for human health. Finally, the analysis of the economics of stored product protection is presented, from theory to practice."-- Provided by publisher.
Contents:
Intro; Preface; Contents; Contributors; 1 Importance of Stored Product Insects; Introduction; Overview of Insect Pest Species Associated with Stored Products; Pests of Grain and Grain Products; Major Primary Pests; Major Secondary Pests; Pests of Dried Fruits and Nuts; Pests of Durable Herbs, Spices, Tobacco and Pet Food Products; Pests of Dried Fish and Other Animal Products; Predators and Parasitoids; Scavengers and Foragers; Implications from Insect Infestations; Economic Implications from Quantitative Loss Due to Physical Damage; Effect on Quality. 6 Insect Pest Management of Oilseed Crops, Tree Nuts and Dried FruitsIntroduction; Commodities; Oilseed Crops; Tree Nuts; Dried Fruits; Insects of Oilseed Crops, Tree Nuts and Dried Fruits; Family Anthribidae-Coleoptera (Beetles); Family Bruchidae; Family Cleridae; Family Cucujidae; Family Dermestidae; Trogoderma Granarium Everts, Khapra Beetle; Trogoderma Inclusum LeConte, Larger Cabinet Beetle; Mycetophagidae; Family Nitidulidae; Family Silvanidae; Oryzaephilus Surinamensis (L.) Saw-Toothed Grain Beetle (Fig. 6.10); Oryzaephilus mercator Fauv., The Merchant Grain Beetle. Grain Protectant InsecticidesConclusions; Acknowledgements; References; 4 Structural Pest Management for Stored Product Insects; Introduction; Pre-binning Treatments for Stored Grains; Fumigants; Modified Atmospheres; Heat and Cold; Aerosols; Contact Surface Sprays; Repellents; Mating Disruption Strategies; Insect Resistant Packaging; Conclusion; Acknowledgements; References; 5 Bacterial Insecticides and Inert Materials; Introduction; Spinosad; Spinetoram; Abamectins; Inert Materials and Nanoparticles; Zeolites; Mineral-Based Particles; Delivery Systems; References. Pest Temperature and Humidity Changes and Physical Grain Destruction and Treatments: Facilitation of Fungal Growth and Mycotoxin ProductionPoisoning by Toxic Insecticides and Rodenticides; Negative Impact of Anoxic Atmospheres and Toxic Fermentation Silo Gases; Human Accidents During Sampling or Pesticide Application in Stores and Silos; Fires, Explosion and Intoxication Due to Fumigation Control of Storage Pests; Acknowledgements; References; 3 Insect Pest Management in Stored Grain; Introduction; Disinfestation; Insecticides; Fumigation; Other Methods; Protection; Cooling. Work Place Health and Safety ImplicationsRejection by Consumers and Loss of Market; Costs Associated with Pest and Resistance Management and Research; Conclusion; Acknowledgements; References; 2 Human Health Problems and Accidents Associated with Occurrence and Control of Storage Arthropods and Rodents; Introduction; Direct Effects on Human Health; Effects on Food Security; Effects on Food Safety; Effects on Home- and Workplace Safety and Occupational Disease Issue; Indirect Health Effects; Transmission and Hosting of Pathogens (Storage Pest Role of Vectors, Hosts). - Digitalvolume editor, Kosaku Nitta.Contents:
The role of caveolae on albumin passage through glomerular endothelial and epithelial cells : the new etiology of urinary albumin excretion / Moriyama, T.; Karasawa, K.; Nitta, K. (Tokyo)
Rituximab as a therapeutic option for steroid-sensitive minimal change nephrotic syndrome in adults / Iwabuchi, Y; Moriyama, T.; Itabashi, M.; Takei, T.; Nitta, K. (Tokyo)
Large renal corpuscle: clinical significance of evaluation of the largest renal corpuscle in kidney biopsy specimens / Kataoka, H.; Mochizuki, T.; Nitta, K. (Tokyo)
New insights into cystic kidney diseases / Mochizuki, T.; Makabe, S.; Aoyama, Y.; Kataoka, H.; Nitta, K. (Tokyo)
Recent advances in the treatment of lupus nephritis / Karasawa, K.; Uchida, K.; Takabe, T.; Moriyama, T.; Nitta, K. (Tokyo)
Association between increases in normalized protein catabolic rate and increases in creatinine generation rate in dialysis patients / Hanafusa, N.; Kamei, D.; Tsukada, M.; Miwa, N. (Tokyo); Komatsu, M.; Shiohira, S.; Okazaki, M.; Kawaguchi, H. (Fukushima); Tsuchiya, K.; Nitta, K. (Tokyo)
Renal anemia and iron metabolism / Ogawa, C. (Kawasaki); Tsuchiya, K. (Kawasaki/Tokyo); Maeda, K. (Kawasaki); Nitta, K. (Tokyo)
Cell sheet engineering and kidney diseases / Oka, M.; Miyabe, Y.; Sugiura, N.; Nitta, K. (Tokyo)
Clinical impact of left ventricular diastolic dysfunction in chronic kidney disease / Ogawa, T. (Tokyo)
Treatment of posttransplantation anemia / Unagami, K.; Okumi, M.; Tamura, T.; Ishida, H.; Tanabe, K.; Nitta, K. (Tokyo)
Role of frailty on outcomes of dialysis patients / Nitta, K.; Hanafusa, N.; Tsuchiya, K. (Tokyo)
Socioeconomics of administering rituximab for nephrotic syndrome / Takura, T.; Takei, T.; Nitta, K. (Tokyo)
Use of beta-blockers on maintenance dialysis patients and ischemic cerebral and cardiovascular deaths: an examination using propensity score / Omae, K; Ogawa, T.; Yoshikawa, M.; Sakura, H.; Nitta, K. (Tokyo)
Direct effects of immunomodulatory agents on podocytes in immune-mediated glomerular diseases / Manabe, S. (Tsukuba/Tokyo); Nitta, K. (Tokyo); Nagata, M. (Tsukuba).Digital Access Karger 2018 - Digitaledited by Katarzyna Chojnacka, Agnieszka Saeid.Contents:
Introduction / Katarzyna Chojnacka
Historical Aspects / Henryk Górecki, Katarzyna Chojnacka
Modern Analytical Methods of Speciation and Determination of Trace Elements in Inorganic, Organic, and Biological Samples / Bogusław Buszewski, Wojciech Piekoszewski, Paweł Pomastowski, Katarzyna Rafińska, Mateusz Sugajski, Tomasz Kowalkowski
Trace Elements in the Environment
Law, Regulations, Monitoring and Biomonitoring Methods / Elżbieta Maćkiewicz, Aleksandra Pawlaczyk, Małgorzata Iwona Szynkowska
Problems of Trace Elements in Water and Wastewater Treatment / Karol Pokomeda, Anna Dawiec-Liśniewska, Daria Podstawczyk, Macarena Rodriguez-Guerra Pedregal, Barbara Ortega Barcelo, Anna Witek-Krowiak
Trace Elements in Agricultural and Industrial Wastes / Aneta Wiśniewska, Agnieszka Saeid, Katarzyna Chojnacka
Trace Elements in Aquatic Environments / Piotr Konieczka, Bartłomiej Cieślik, Jacek Namieśnik
Trace Metals in Soils / Philiswa N Nomngongo, Joseph M Matong, Tshimangandzo S Munonde
The Role of Trace Elements in Living Organisms / Elżbieta Gumienna-Kontecka, Magdalena Rowińska-Żyrek, Marek Łuczkowski
Fluorine and Silicon as Essential and Toxic Trace Elements / Izabela Michalak, Katarzyna Chojnacka
Biological Functions of Cadmium, Nickel, Vanadium, and Tungsten / Agnieszka Dmytryk, Łukasz Tuhy, Mateusz Samoraj, Katarzyna Chojnacka
Biosorption of Trace Elements / Inga Zinicovscaia
Bioaccumulation and Biomagnification of Trace Elements in the Environment / Małgorzata Iwona Szynkowska, Aleksandra Pawlaczyk, Elżbieta Maćkiewicz
Hydrometallurgy and Bio-crystallization of Metals by Microorganisms / Zygmunt Sadowski, Agnieszka Pawlowska
Trace Elements as Fertilizer Micronutrients / Izabela Michalak, Agnieszka Saeid, Katarzyna Chojnacka, Mateusz Gramza
Trace Elements in Animal Nutrition / Łukasz Tuhy, Agnieszka Dmytryk, Mateusz Samoraj, Katarzyna Chojnacka
Trace Elements in Human Nutrition / Klaudia Konikowska, Anna Mandecka
Trace Elements in Human Health / Renata Mozrzymas
Spirulina as a Raw Material for Products Containing Trace Elements / Liliana Cepoi, Tatiana Chiriac, Ludmila Rudi, Svetlana Djur, Liliana Zosim, Valentina Bulimaga, Ludmila Batir, Daniela Elenciuc, Valery Rudic
Dietary Food and Feed Supplements with Trace Elements / Athanasios C Pappas, Katarzyna Godlewska, Peter F Surai
Biofortification of Food with Trace Elements / Mateusz Samoraj, Łukasz Tuhy, Agnieszka Dmytryk, Katarzyna Chojnacka
Biomarkers of Trace Element Status / Katarzyna Chojnacka, Marcin Mikulewicz
Human Exposure to Trace Elements from Dental Biomaterials / Marcin Mikulewicz, Katarzyna Chojnacka
Industrial Use of Trace Elements and their Impact on the Workplace and the Environment / Piotr Rusek, Marzena Mikos-Szymańska
Speciation of Trace Elements and its Importance in Environmental and Biomedical Sciences / Aleksandra Pawlaczyk, Elżbieta Maćkiewicz, Małgorzata Iwona Szynkowska
Trace Elements
A Threat or Benefit? / Katarzyna Chojnacka, Izabela Michalak, Agnieszka Saeid, Katarzyna Godlewska, Łukasz Tuhy, Mateusz Samoraj, Agnieszka Dmytryk, Aneta Wiśniewska. - DigitalShabir Hussain Wani, editor.Summary: This edited volume summarizes the recent advancements made in plant science including molecular biology and genome editing, particularly in the development of novel pathways tolerant to climate change-induced stresses such as drought, extreme temperatures, cold, salinity, flooding, etc. These stresses are liable for decrease in yields in many crop plants at global level. Till date conventional plant breeding approaches have resulted in significant improvement of crop plants for producing higher yields during adverse climatic conditions. However, the pace of improvement through conventional plant breeding needs to be accelerated in keeping with the growing demand of food and increasing human populationl, particularly in developing world. This book serves as a comprehensive reference material for researchers, teachers, and students involved in climate change-related abiotic stress tolerance studies in plants.
Contents:
Intro; Foreword; Preface; Contents; About the Editor; Omics Technologies for Abiotic Stress Tolerance in Plants: Current Status and Prospects; 1 Introduction; 2 Insights into Omics in Plant Abiotic Stress; 3 Genomics: Elucidating Stress-Responsive Genes; 4 Transcriptomics: A Closer Look at Transcripts; 5 Proteomics: A Key for Understanding Protein Structure, Function, and Regulation; 6 Metabolomics in Plant Abiotic Stress; 7 Lipidomics; 8 Proteogenomics: A Comprehensive Approach for Elucidating Regulatory Mechanisms; 9 miRNAomics: For the Better Understanding of the Small RNA Networks 10 Prime-Omics: A Comprehensive Approach to Priming11 Bioinformatics: Tools for Integrating All Omics Approaches; 12 Conclusion; References; Genome Editing and Abiotic Stress Tolerance in Crop Plants; 1 Introduction; 2 Types of Crop Plant Genome Editing Tools; 2.1 Zinc Finger Nuclease; 2.2 Transcription Activator-Like Effector Nucleases (TALEN); 2.3 Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR/Cas9); 3 Uses of CRISPR/Cas9 in Enhancing Abiotic Stress Tolerance in Crops; 3.1 Drought; 3.2 Salinity; 3.3 Heavy Metals; 3.4 Cold Stress; 4 Conclusion; References 2 Screening for Various Abiotic Stress Tolerance2.1 Cold Stress; 2.2 Drought Stress; 2.2.1 Salt Stress; 3 Conclusion; References; Micromics: A Novel Approach to Understand the Molecular Mechanisms in Plant Stress Tolerance; 1 Introduction; 2 Biogenesis of miRNAs; 3 List of Bioinformatics Tools for miRNAs Prediction, Identification and Characterization; 4 Role of miRNAs in Plant Abiotic Stress Tolerance; 4.1 Drought; 4.2 Cold; 4.3 Salt; 4.4 High Temperature; 5 Role of miRNAs in Plant Biotic Stress Tolerance; 5.1 Viruses; 5.2 Bacteria; 5.3 Fungal; 5.4 Nematodes; 5.5 Insect Pests; 6 Conclusion Metabolomic Profiling of Plants to Understand Reasons for Plant Stress Resilience to Abiotic Stress1 Gas Chromatography-Mass Spectrometry (GC-MS); 2 Liquid Chromatography (LC)-MS; 3 Capillary Electrophoresis (CE)-MS; 4 Nuclear Magnetic Resonance (NMR) Spectroscopy; 5 Water Stress; 6 Temperature Stress; 7 Light Stress; 8 Ion Stress; 9 Oxidative Stress; 10 Combination of Stresses; 11 Toward the Elucidation of Molecular Mechanisms Underlying Abiotic Stress Tolerance; References; In Vitro Screening of Crop Plants for Abiotic Stress Tolerance; 1 IntroductionDigital Access Springer 2019 - DigitalDigital Access
- DigitalDeborshi Sharma, Priya Hazrah, editors.Summary: The book covers the recent developments in various aspects of minimal access surgery (laparoscopic and robotic surgery), which is fairly a new branch of surgery that has advanced tremendously in last few years. This is the first volume of the set of books on recent concepts in minimal access surgery. It provides step-by-step descriptions accompanied by numerous helpful photographs and anatomical drawings. It also includes the controversies and gives a cumulative opinion on the recent changes developing in minimal access surgery (MAS). It includes system wise topics and separate chapters on the different topics within the system with the meta-analysis of recent topic or their controversies. The book is useful for practitioners and young faculties as well as residents, trainees and fellows of surgery and minimal access surgery.
Contents:
Laparoscopic Fundoplication: Current Scenario
Minimally Invasive Procedures for Rectal Prolapse
Trans Anal Total Meso rectal excision
Pain Prevention after Laparoscopic Inguinal Hernia
Abdominal Wall Reconstruction: Recent advances
Extended view TEP: How is it different to TEP? Current evidence
Mini Gastric Bypass
Robotic Roux en-Y Gastric Bypass
Laparoscopic Subtotal Cholecystectomy
Predictors of Difficult Lap Chole
Laparoscopic management of massive spleen: Current perspective
Robotic Whipple procedure
Laparoscopic Donor Nephrectomy
Laparoscopic D2 Gastrectomy
Staging Laparoscopy
Ergonomics in Laparoscopic Surgery
Energy Sources
Third space endoscopy
Management of solitary pulmonary nodule
Laparoscopic adrenalectomy. - DigitalArti Gupta, Nagendra Pratap Singh, editors.Summary: Fungal growths affect both human and animal well-being. Many natural pathogens of laboratory animals alter host physiology, rendering the host unsuitable for experimental uses. While the number and prevalence of few pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using laboratory animals in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. What does the future hold regarding the natural pathogens of laboratory animals? The selection of an animal model must carefully address issues of the type of human disease to mimic, the parameters to follow, and the collection of the appropriate data to answer those questions being asked. Overall, animal models of fungal infection will continue to deepen our understanding of how these infections occur. This book provides a valuable source of information to biological and biomedical scientists and to clinical and doctoral researchers working in the area of fungal infections and diseases of laboratory animal species.
Contents:
Intro; Preface; Acknowledgements; Contents; About the Editors;
Chapter 1: Emerging Infectious Diseases Caused by Fungi in Animals and Their Prevention; 1.1 Introduction; 1.2 Fungal Diseases in Animals; 1.3 Factors Affecting the Transmission of Diseases and Their Control Measures; 1.4 Conclusions and Future Prospects; References;
Chapter 2: Fungal Diseases of Honey Bees: Current Status and Future Perspective; 2.1 Introduction; 2.2 Major Milestones in Microsporidia Research; 2.3 Morphology of Microsporidia; 2.3.1 Life Cycle; 2.4 Geographical Distribution 2.5 Factors Affecting Microsporidian Infection2.6 Lacunae in Knowledge; 2.7 Knowledge of the Pathogen So Far; 2.8 Pathogenesis; 2.8.1 Physiological and Behavioral Perturbation in Honey Bees; 2.9 Treatment; 2.9.1 Diagnosis; 2.10 Occurrence of Other Fungal Pathogens; 2.10.1 Stonebrood Disease; 2.10.2 Chalkbrood Disease; 2.11 Parasitized Honey Bee Immune Gene Suppression; 2.12 Conclusion; 2.12.1 Future Directions; 2.12.2 New Insights; References;
Chapter 3: Immunological Diagnosis of Fungal Disease in Animals; 3.1 Introduction; 3.2 Laboratory Testing for Fungal Identification 3.3 Microscopic and Macroscopic Examination3.4 Immunology of Fungal Infection; 3.5 Immunological Techniques for Fungal Diseases; 3.6 Immunofluorescence; 3.7 Immunoperoxidase Staining; 3.8 Counter-Immunoelectrophoresis (CIE); 3.9 Immunodiffusion (ID); 3.10 Immunoblotting; 3.11 Latex Particle Agglutination; 3.12 Tube Precipitin and Complement Fixation Tests; 3.13 Enzyme-Linked Immunosorbent Assay (ELISA); 3.14 Antigens Useful for Diagnosis; 3.15 Conclusion; 3.16 Future Prospects; References;
Chapter 4: Aspergillosis in Birds and Mammals: Considerations for Veterinary Medicine; 4.1 Introduction 4.10 Conclusions and Future DirectionsReferences;
Chapter 5: Fungal Diseases of Animals: Symptoms and Their Cure by Natural Products; 5.1 Introduction; 5.2 Mechanism of Antibiotic Action; 5.3 Mechanism of Antibiotic Resistance; 5.4 Methodology for Carrying Out Antibacterial Activity; 5.4.1 Cleaning of Glassware; 5.4.2 Sterilization; 5.4.2.1 Dry Heat Sterilization; 5.4.2.2 Moist Heat Sterilization; 5.4.2.3 Direct Flaming; 5.4.2.4 Ultraviolet (UV) Sterilization; 5.4.3 Preparation of Culture Media; 5.5 Evaluation of Antibacterial Activity by Agar Well Diffusion Method 4.2 Epidemiology4.2.1 Aspergillosis in Mammals; 4.2.2 Aspergillosis in Birds; 4.2.3 Susceptibility of Various Birds; 4.2.3.1 Free-Ranging Birds; 4.2.3.2 Domestic (Poultry) Birds; 4.2.3.3 Captive Birds (Companion, Rehabilitated, and Zoological Collection); 4.2.3.3.1 Companion Birds; 4.2.3.3.2 Rehabilitation/Zoological Collection Birds; 4.3 Etiology; 4.4 Clinical Signs; 4.5 Antemortem Diagnostics; 4.6 Culture and Identification; 4.7 Postmortem Evaluation; 4.8 Treatment; 4.9 Prevention; 4.9.1 Monitoring and Epidemiology; 4.9.2 Vaccination; 4.9.3 Environmental ControlDigital Access Springer 2019 - DigitalJagdish N. Sharma, editor.Contents:
Basic and clinical aspects of bradykinin receptor antagonists
The kallikrein-kinin pathways in hypertension and diabetes
Tissue Kallikrein-kinin therapy in hypertension and organ damage
Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension
The Kallikrein-kinin system in diabetic retinopathy
Genetic manipulation and genetic variation of the Kallikrein Kinin System; impact on cardiovascular and renal diseases. - DigitalAhmed M. Abdel-Azeem, editor.Summary: Chaetomium genus was established by Gustav Kunze in 1817. According to Index Fungorum Partnership, there are 273 Chaetomium species accepted till now. Members of the genus Chaetomium are capable of colonizing various substrates and are well-known for their ability to degrade cellulose and to produce a variety of bioactive metabolites. More than 200 compounds have been reported from this genus. A huge number of new and bioactive secondary metabolites associated with unique and diverse structural types, such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, depsidones, xanthones, anthraquinones, chromones, and steroids, have been isolated and identified. Many of the compounds have been reported to possess significant biological activities, such as antitumor, antimalarial, cytotoxic, enzyme inhibitory, antimicrobial, phytotoxic, antirheumatoid and other activities. Chaetomium taxa are frequently reported to be cellulase and ligninase producers with the ability to degrade cellulosic and woody materials. This is the first, comprehensive volume covering Chaetomium genus in detail. It includes the latest research, methods, and applications, and was written by scholars working directly in the field. The book also contains informative illustrations and is fully referenced for further reading.
Contents:
Intro
Foreword
Preface
Acknowledgments
Contents
About the Editor
Part I: Chaetomium: Biology to Biotechnology
Chapter 1: Taxonomy and Biodiversity of the Genus Chaetomium in Different Habitats
1.1 Introduction
1.2 Taxonomic History
1.2.1 Cultural Conditions of Chaetomium
1.2.2 Morphological Characterization of Chaetomium Species
1.3 Methodology of Studying Chaetomium Biodiversity
1.3.1 Phenotypic Studies
1.3.2 Numerical Taxonomy:
1.3.3 Secondary Metabolites Profiling and Chemotaxonomy
1.3.4 Molecular Characterization
1.3.5 DNA Barcoding 1.3.6 Evolution of the Approach: Polyphasic Taxonomy of Chaetomium
1.4 Chaetomium Diversity in Different Habitats
1.4.1 Desert
1.4.2 Salterns and Mangrove
1.4.3 Occurrence in Indoor Air
1.4.4 Occurrence in Water
1.4.5 Occurrence in Foods
1.4.6 Polar
1.4.7 On Herbivore Dung
1.4.8 Living Plants, Lichens, and Animals
1.4.9 Human
1.4.10 Decaying Wood
1.5 Conclusion
References
Chapter 2: Developmental Morphology of Chaetomium and Chaetomiopsis
2.1 Introduction
2.2 Preparation of Samples for Light and Electron Microscopy
2.3 Volume Determination 2.4 Structure of the Ascogonium and Formation of the Ascoma
2.5 Structure of the Peridium
2.5.1 Peridium in Surface View
2.5.2 Peridium in Section
2.6 Peridial Hairs (Morphology and Ultrastructure)
2.7 Development of Ostiolar Apparatus
2.8 Ascospores
2.9 Expansion of the Ascoma
2.10 Discussion
References
Chapter 3: Molecular Approaches for Analyzing Environmental Chaetomium Diversity and Exploitation of Chaetomium thermophilum for Biochemical Analyses
3.1 Introduction
3.2 Molecular Methods for the Detection of Fungi
3.2.1 PCR-Based Methods 3.2.1.1 Conventional PCR
3.2.1.2 Nested PCR
3.2.1.3 Multiplex PCR
3.2.1.4 Reverse Transcriptase PCR
3.2.1.5 Real-Time PCR (Q PCR)
3.2.1.6 Serial Analysis of Gene Expression
3.2.1.7 DNA Barcoding
3.3 DNA/RNA Probe-Based Methods (Sequencing-Independent Methods)
3.3.1 Northern Blotting
3.3.2 In Situ Hybridization
3.3.3 Fluorescence In Situ Hybridization
3.4 Post-Amplification Technique
3.4.1 Microarray
3.4.2 Macroarray
3.5 Isothermal Amplification-Based Methods
3.5.1 Rolling Circle Amplification
3.5.2 Loop-Mediated Isothermal Amplification 3.5.3 Nucleic Acid Sequence-Based Amplification
3.6 RNA Interference
3.7 RNA-Seq-Based Next-Generation Sequencing
3.8 Taxonomy and Molecular Phylogeny of Thermophilic Chaetomium
3.8.1 Molecular Phylogeny of Thermophilic Fungi
3.8.2 Thermophilic Fungal Genomes
3.8.3 Preferred Gene Sequences of Chaetomium
3.9 Developing Genetic Tools to Exploit C. thermophilum
3.9.1 Methods (Fig. 3.5)
References
Chapter 4: Recent Advances on Occurrence of Genus Chaetomium on Dung
4.1 Life Cycle of Dung Fungi and the Classification as an Obligate Dung SpeciesDigital Access Springer 2020 - DigitalM. Shimizu (ed.).Summary: Child and adolescent psychiatry is a complex clinical discipline whose practitioners work in close cooperation with their professional colleagues in clinical medicine, education, social welfare, sociology, family relations theory, and legal affairs. This volume, the first of its kind to be published in Japan, provides a broad-ranging view of recent progress in the rapidly developing field of child and adolescent psychiatry. Topics include infant psychiatry, developmental disorders, the interface between education and psychiatry (especially as it relates to the phenomenon of "school refusal") neurotic disorders, and adolescent psychoses, as well as parental power and child abuse, and psychiatric problems surrounding organ transplantation in children. The section on autism and education focuses on problems of autistic children reaching adolescence, a subject that has rarely been treated so directly. Also of clinical interest and importance is the discussion presented here of high-risk factors for adolescent psychosis. This volume, with contributions by leading professionals in the field, is a valuable source and reference for practitioners, researchers, and students of child and adolescent psychiatry and clinical psychology
Contents:
1. Developmental Disorders
Present Conditions and Problems at Facilities for Autistic Adults
Psychosexual Development of Autistic Children During Adolescence
Regression in Mental Development Following a Psychosocial Stressor in Disintegrative Psychosis
Longitudinal Study on Treatment and Outcome for Autistic Children
Review of Learning Disability Studies in Japan
2. Infant Psychiatry
Infant Psychiatry: Review of Recent Trends
3. School Refusals
Nonattendance at School (School Phobia): Clinical Aspects and Psychopathology
School Refusal and Family Pathology: Individualized and Multifaceted Approach
Study on the Experience of Being Bullied: Children Refusing School Who Resort to Violence Within the Family
Education and Its Relation to Child and Adolescent Psychiatry: Problem of School Hating
Nosological Constellation of School Refusal Syndrome
4. Neurotic Disorders
Clinical Study of Conversion Disorders in Adolescents
Clinical Picture of Obsessive-Compulsive Disorder During Childhood
5. Psychotic Disorders
Developmental Profiles: Early-Onset Compared to Late-Onset Schizophrenia and Affective Disorders
Clinical Study of Childhood Schizophrenia
Depressive Disorder During Childhood and Adolescence in Japan
6. Other Fundamental Problems
Psychiatric Problems of Living Kidney Transplantation in Child and Adolescent Recipients
Child Abuse and Parental Power in Japan
Training and Education of Child Mental Health Professions in Japan
Keyword Index
Author Index. - DigitalYoko Kato, Xiaohua Zhang, Jiong Dai, Ahmed Ansari, editors.Summary: This book has included 19 recent topics about the treatment of cerebrovascular diseases from basics to surgical (include microneurosurgical, endovascular, endoscopic and Stereotactic radiosurgical techniques) aspects in the management of cerebrovascular diseases. With illustrative cases, the treatment strategies, techniques and complication avoidance have been covered extensively in the chapters to guide the readers on when and what to expect the worst in surgeries. The neurosurgical aspect in the present scenario of COVID is also included. This book will assist the junior neurosurgeons and junior neurological physicians in endeavoring to learn the core concepts and common problems of cerebrovascular surgery. This is a worthwhile addition in this ever growing field of cerebrovascular surgery.
Contents:
1 Aneurysm wall property
2 Pathogenesis Of Thrombosed Giant Aneurysm
3 Cerebral vasospasm and Subarachnoid hemorrhage
4 White fibers of the brain: A novel classification
5 Computational Fluid Dynamics in cerebral aneurysms
6 Carotid Endarterectomy - Surgical nauances
7 Blister aneurysm of Middle cerebral artery bifurcation (case report and review)
8 Flexible endoscopic aspiratin of intraventricular hemorrhage
9 Endoscopic evacuation of cerebral hematoma
10 Management (surgical and endovascular) of acute ischemic stroke
11 Contralateral aneurysm clipping
12 Multimodality management of brain AVMs
13 Superficial temporal artery- middle cerebral artery bypass combined with encephalo-duro-myo-synangiosis in treating Moyamoya disease
14 Stereotactic radiosurgery for brain AVMs
15 Endovascular recanalization for chronic occlusion of carotid artery
16 Multimodality technique of microvascular decompression syndrome
17 Posterior circulation aneurysms management
18 Onyx embolization of intracranial dural arteriovenous fistula (trans-arterial approach, trans-venous approach and combined approach)
19 Experience in Neurosurgery during the prevalence of COVID-19. - Digitaleditors, John Colombo, Berthold Koletzko, Michelle Lampl.Contents:
Implications of growth as a time-specific event / M. Lampl
Elongation of the long bones in humans by the growth plates / E.B. Hunziker
Critical windows for the programming effects of early-life nutrition on skeletal muscle mass / M.L. Fiorotto, T.A. Davis
Fat tissue growth and development in humans / P. Arner
Osteoblast bioenergetics and global energy homeostasis / A.R. Verardo, T.L. Clemens
Summary on a systems perspective on growth / M. Lampl
Breastfeeding, breast milk composition, and growth outcomes / M.V. Lind, A. Larnkjar, C. Molgaard, K.F. Michaelsen
Metabolic regulation of pre- and postnatal growth / B. Koletzko, F.F. Kirchberg, C. Hellmuth, M. Weber, V. Grote, H. Demmelmair, M. Standl, J. Heinrich, E. Thiering, O. Uhl
Complementary feeding, infant growth, and obesity risk : timing, composition, and mode of feeding / V. Grote, M. Theurich, V. Luque, D. Gruszfeld, E. Verducci, A. Xhonneux, B. Koletzko
Causes of stunting and preventive dietary interventions in pregnancy and early childhood / R.E. Black, R. Heidkamp
Micronutrients and child growth : current evidence and progress / R. Sharma, T. Vaivada, Z.A. Bhutta
Summary on dietary modulation of growth and body composition / B. Koletzko
A nutritionist's perspective on behavioral assessment / S.E Carlson
Assessing neurocognitive development in studies of nutrition / J. Colombo
Neuroimaging of the developing brain and impact of nutrition / S.C.L. Deoni
Effects of nutrition on the development of higher-order cognition / P. Willatts
Impact of nutrition on growth, brain, and cognition / M.M. Black
Summary on nutrition, brain function, and cognitive development / J. Colombo.Digital Access Karger 2018 - PrintSundas Fayyaz, Ammad Ahmad Farooqi, editors.Summary: Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R & D departments.
- DigitalKaruna Singh, Neelabh Srivastava, editors.Summary: Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the readers convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.
Contents:
Part I Human and Animal Mycoses
Pythiosis
Superficial Mycoses in Dogs and Cats
Pathogenic Chrysosporium-related Fungi in Reptiles and Other Animals
Aspergillosis in Humans and Animals
Some Clinically Significant Genera of Dematiaceous Hyphomycetes: An Update
Endemic Mycoses in Americas
Part II Mycotoxins in Relation to Human and Animal Health
Mycotoxins and Their Inhalatory Intake Risk
Tenuazonic acid:A Potent Mycotoxin
Part III Antifungal Therapeutic Candidates
Phytochemicals: New Avenues in Anti-Candidal Activity
Recent Advances in Coumarins as Antifungal Agents. - DigitalAjar Nath Yadav, editor.Springer Nature eBook.Summary: Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients - a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and enhance soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play a significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrade waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of Recent Trends in Mycological Research aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.
Contents:
Preface
Mycological Research for Agriculture and Medical Importance: An Introduction
Beneficial Fungal Communities from Agricultural Soil for Plant Growth Promotion and Soil Health
Plant Growth Promoting Fungi: Mechanisms and Applications for Crop Productivity
Alleviation of Diverse Abiotic Stress in Plant Through the Fungal Communities
Phosphate Solubilizing Fungi: Current Perspective and Future Need for Agricultural Sustainability
Fe-Chelating Compounds Producing Fungal Communities and their Applications
Fungal Diversity and Ecology: Major Challenges for Crop Production in Present Climate Scenarios
Arbuscular Mycorrhizal Fungi: Interactions with Plants and their Role in Agricultural Sustainability
Portraying Fungal Mechanisms in Stress Tolerance: Perspective for Sustainable Agriculture
Fungal Communities as Biological Control Agents for Different Phytopathogenic Organisms
Fungal Nanoparticles for Sustainable Agriculture
Medically Important Fungi: Biodiversity, Abundances, and Applications
Isolation and Molecular Characterization of Medically Important Fungi: Current Research and Future Prospects
Human Fungal Pathogens: Diversity, Genomics, and Preventions
Formation, Resistance, and Pathogenicity of Fungal Biofilms: Current Trends and Future Challenges
Mycological Interactions: Beneficial Impact on Pathogenesis and Human Disease
Medical Applications of Fungal Nanotechnology: Current Research and Future Scope
Agriculturally and Medically Important Fungi: Conclusion and Future Vision
Bibliography
Index. - DigitalAjar Nath Yadav, editor.Summary: Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients--a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrading waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of "Recent Trends in Mycological Research" aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.
Contents:
Preface
1. Bioprospecting and Applications of Fungi: A Game Changer in Present Scenario
2. Fungal Communities for Bioremediation of Contaminated Soil for Sustainable Environments
3. White-Rot Fungi for Bioremediation of Polychlorinated Biphenyl Contaminated Soil
4. Fungal Secondary Metabolites for Bioremediation of Hazardous Heavy Metals
5. Fungal Enzymes: Degradation and Detoxification of Organic and Inorganic Pollutants
6. Fungal Communities for the Remediation of Environmental Pollutants
7. Microbial Consortia for Effective Degradation and Decolorization of Textile Effluents
8. Fungi in Remediation of Hazardous Wastes: Current Status and Future Outlook
9. Applications of Myco-Nanoparticles in Remediation: Current Status and Future Challenges
10. Marine Fungal Communities: Metabolic Engineering for Secondary Metabolites and their Industrial Applications
11. Industrially Important Fungal Enzymes: Productions and Applications
12. Fungal Exopolysaccharides: Production and Biotechnological Industrial Applications in Food and Allied Sectors
13. Neoteric Trends in Medicinal Plant-AMF Association and Elicited Accumulation of Phytochemicals
14. Fungal Endophytes from Orchidaceae: Diversity and Applications
15. Fungal Mycotoxins-Occurrence and Detection
16. Preservative Efficacy of Essential Oils against Post-harvested Fungi and Insects of Food Commodities A Prospect to Go Green
17. Fungal Biorefineries for Biofuel Production for Sustainable Future Energy Systems
18. Environmental and Industrial Perspective of Beneficial Fungal Communities: Current Research and Future Challenges
Index. - Digitaledited by Serena Germano.Contents:
Analysis of receptor tyrosine kinase (RTK) phosphorylation by immunoblotting / Martina McDermott and Norma O'Donovan
Analysis of changes in phosphorylation of receptor tyrosine kinases : antibody arrays / Sweta Rani and Lorraine O'Driscoll
Analysis of epidermal growth factor receptor dimerization by BS³ cross-linking / Harmony F. Turk and Robert S. Chapkin
Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells / Inhee Chung and Ira Mellman
Evaluation of the dimerization profiles of HER tyrosine kinases by time-resolved Förster resonance energy transfer (TR-FRET) / Evelyne Lopez-Crapez [and three others]
Applying the proximity ligation assay (PLA) to mouse preimplantation embryos for identifying protein-protein interactions in situ / Ivan Bedzhov and Marc P. Stemmler
Analysis of receptor tyrosine kinase gene amplification on the example of FGFR1 / Diana Boehm, Anne von Mässenhausen, and Sven Perner
Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells / Lijuan He and Kalina Hristova
Cell surface biotinylation of receptor tyrosine kinases to investigate intracellular trafficking / Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan
Studying N-linked glycosylation of receptor tyrosine kinases / Harri M. Itkonen and Ian G. Mills
Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen / Hojin Lee and Anton M. Bennett
Downregulation of receptor tyrosine kinases through ubiquitination : analysis by immunodetection / Noriaki Shimokawa and Noriyuki Koibuchi
Regulation of receptor tyrosine kinases by miRNA : overexpression of miRNA using lentiviral inducible expression vectors / XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai
Human tumor xenografts in mouse as a model for evaluating therapeutic efficacy of monoclonal antibodies or antibody-drug conjugate targeting receptor tyrosine kinases / Liang Feng [and five others]
Receptor tyrosine kinase targeting in multicellular spheroids / Susan Breslin and Lorraine O'Driscoll
Receptor tyrosine kinases and drug resistance : development and characterization of in vitro models of resistance to RTK inhibitors / Claire Corcoran and Lorraine O'Driscoll.Digital Access Springer 2015 - Printedited by Jorge R. Pasqualini.
- Digital/Printpar Edouard Dulaurier.Contents:
t.
1. Chronologie technique.Digital Access Google Books 1859- - DigitalRaffi Gurunian, Risal Djohan, editors.Summary: This book offers a comprehensive review of reconstructive microsurgery with an emphasis on the recipient vasculature. Chapters describe the anatomy, exposure, and technical considerations of recipient vessels in reconstructive microsurgery. The book strives to fill that void of literature covering recipient vessels and their surgical exposure for microvascular anastomosis. Alongside nuanced description for each particular body structure, the chapters will provide illustrations and short video clips on how to prepare these essential vessels. The book is the accumulation of the editors many years of experience in Asia, Europe, and the United States and also features contributions from world experts. Recipient Vessels in Reconstructive Microsurgery -- Anatomy and Technical Considerations is a must-have resource for trainees and residents as well as surgeons working in plastic surgery and microsurgery.
Contents:
Intro
Preface
Contents
Contributors
Part I: Introduction
1: Recipient Vessels for Microsurgery
Introduction
Preoperative Assessment
Surgical Site Exposure
Microvascular Anastomoses
Conclusion
References
Part II: Head and Neck Reconstruction
2: External Carotid Branches/External Jugular/Internal Jugular
Introduction
Arterial Anatomy and Selection
Venous Anatomy and Selection
External Jugular Vein
Internal Jugular Vein
Nerve and Lymphatic Anatomy and Considerations
Conclusion
References 3: Minimal Access Approach for Facial Vessels
Introduction
Preoperative Considerations
Relevant Anatomy
Operative Technique
Discussion
Conclusion
References
4: Angular Vessels
Introduction
Preoperative Considerations
Relevant Anatomy
Operative Technique
Discussion
Conclusion
References
5: Superficial Temporal Vessels
Introduction
Preoperative Assessment
Applied Anatomy
Surgical Site Exposure
Discussion
References
6: Transverse Cervical Vessels
Introduction
Applied Anatomy
Surgical Site Exposure
Discussion Conclusion
References
7: Recipient Vessels: Laryngopharynx Reconstruction
Introduction
Upper Cervical Vessels
Carotid and Jugular Systems
Applied Anatomy
Transverse Cervical Vessels
Surgical Site Exposure
Vessels Outside the Head and Neck Region
Discussion
Algorithm for Recipient Vessel Selection
Preoperative Assessment Tools
Technical Pearls
Conclusion
References
8: Recipient Vessels: Voice Reconstruction
Introduction
Anatomy of the Larynx and Phonatory Physiology
Vascular Anatomy of the Neck
Branches of the Carotid System Venous Anatomy of the Neck
The Transverse Cervical Vessels
The Thoracoacromial Vessels
The Cephalic Vein
Surgical Options for Voice Reconstruction
Recipient Vessels for Voice Reconstruction: Selection and Surgical Exposure
Discussion
References
9: Recipient Vessels: Esophagus Reconstruction
Introduction
Overview of Free Tissue Transfer Options
Recipient Arteries: External Carotid Arterial System
Recipient Veins: Internal and External Jugular Venous System
Recipient Vessels in the Vessel-Depleted Neck
Contralateral Neck Vessels Transverse Cervical Vessels
Subclavian Artery, Thoracoacromial Vessels, and Internal Mammary Vessels
Dorsal Scapular Vessels
Cephalic Vein
Technique
Preoperative Assessment
Anastomosis
Anticoagulation
Postoperative Care
Conclusion
References
Part III: Trunk Reconstruction
10: Internal Mammary Vessels: Inframammary and Standard Approach
Introduction
Preoperative Assessment
Applied Anatomy
Surgical Site Exposure
Inframammary Fold Incision: Modifications in Technique
Delayed Immediate Reconstruction: Modifications in Technique
Discussion - DigitalAlan E. Oestreich, Marguerite M. Caré.Contents:
Introduction
Plain images
Ultrasound, CT, MR, Nuclear Imaging, PET
Rule out alternate diagnosis
Neuroradiology
Abdominal Thoracic, and subcutaneous abnormalities
Beyond the images
Contra the zealous abuse deniers
Documenting concern for abuse
Importance and role of non-radiologist child abuse team
Conclusion.Digital Access Springer 2017 - DigitalTheam Soon Lim, editor.Contents:
1. Filamentous phage: structure and biology
2. Antibody phage display
3. Naive human antibody libraries for infectious diseases
4. Immune human antibody libraries for infectious diseases
5. Synthetic antibodies in infectious disease
6. Monoclonal antibodies and antibody like fragments derived from immunised phage display libraries
7. Anti-bacterial monoclonal antibodies
8. Anti-parasitic antibodies from phage display
9. Therapeutic antibodies for biodefense
10. Engineering antibodies for the treatment of infectious diseases
11. Computer-aided antibody design: an overview
12. Using high-throughput sequencing to characterize the development of the antibody repertoire during infections: a case study of HIV-1
13. Safety and general considerations for the use of antibodies in infectious diseases
Index. - PrintSusan J. Noonan, MD, MPH.Summary: "An accessible, concise, and comprehensive guide to understanding and dealing with the impact and consequences of social isolation"-- Provided by publisher. "In Reconnecting after Isolation, Dr. Susan J. Noonan draws on our collective experience of the COVID-19 pandemic to help readers deal with the emotional impact of social isolation. Speaking as both a provider and recipient of mental health care services, Noonan combines her professional and personal experiences in an evidence- based and practical guide. Drawing on meticulous research and interviews with four psychologists, she outlines steps to overcome the emotional trauma of isolation. The book touches on how social isolation, loneliness, and stress affect each of us individually and can sometimes provoke depression, anxiety, post-traumatic stress disorder, suicidality, and substance use. Describing specific lifestyle interventions that may help, it offers tips for - developing effective coping skills - facing isolation-induced fears adapting effectively to the changes in our personal, family, work, academic, and social lives caused by imposed isolation - finding effective, culturally sensitive mental health care - improving sleep hygiene - building and maintaining resilience - adopting a healthy diet - overcoming the fatigue burnout - grieving a loss - engaging in regular physical exercise - keeping a daily routine or structure - maintaining contact with others Dr. Noonan also discusses re-entry anxiety, the challenging experience many have upon returning to their prior lifestyle, and the difficulty of establishing new school and work routines following social isolation"-- Publisher's description. How to keep calm, carry on, and reconnect during times of social isolation and emotional crisis. Although spending time alone for short periods may be restorative and helpful, unintentional or involuntary isolation can have profound detrimental effects on emotional and physical health. We all need social interaction and meaningful relationships in our lives to be well and thrive. Without them, we flounder. In Reconnecting after Isolation, Dr. Susan J. Noonan draws on our collective experience of the COVID-19 pandemic to help readers deal with the emotional impact of social isolation. Speaking as both a provider and recipient of mental health care services, Noonan combines her professional and personal experiences in an evidence-based and practical guide. Drawing on meticulous research and interviews with four psychologists, she outlines steps to overcome the emotional trauma of isolation. The book touches on how social isolation, loneliness, and stress affect each of us individually and can sometimes provoke depression, anxiety, post-traumatic stress disorder, suicidality, and substance use. Describing specific lifestyle interventions that may help, it offers tips for developing effective coping skills ; facing isolation-induced fears ; adapting effectively to the changes in our personal, family, work, academic, and social lives caused by imposed isolation ; finding effective, culturally sensitive mental health care ; improving sleep hygiene ; building and maintaining resilience ; adopting a healthy diet ; overcoming the fatigue burnout ; grieving a loss ; engaging in regular physical exercise ; keeping a daily routine or structure ; maintaining contact with others. Dr. Noonan also discusses re-entry anxiety, the challenging experience many have upon returning to their prior lifestyle, and the difficulty of establishing new school and work routines following social isolation. Accessible and compassionate, Reconnecting after Isolation empowers individuals to manage their own challenges, offering them a better chance of recovery and of staying well. -- Provided by publisher.
Contents:
Part One. How does social isolation affect me?
Chapter 1. What is Social Isolation?
Chapter 2. Stress and Coping Skills
Chapter 3. Facing Our Fears
Chapter 4. Fatigue and Burnout
Chapter 5. The Ability to Grieve
Chapter 6. Isolation and Mental Health
Chapter 7. Suicidal Thoughts or Impulses
Chapter 8. Substance Abuse and Addictions
Part Two. What can I do to help myself?
Chapter 9. Understanding the Basics of Mental Health
Chapter 10. Finding Effective Professional Mental Health
Chapter 11. Is Talk Therapy Right for Me?
Chapter 12. Building and Maintaining Resilience
Chapter 13. Looking Forward : Reentry Anxiety
Final ThoughtsDigital Access R2Library [2022], ©2022 - Digitaledited by Ron Vale ; contributors Anna Akhmanova [and seven nine others].Contents:
Actin filament dynamics using microfluidics
Bacterial actin-like proteins: purification and characterization of self-assembly properties
Quantitative analysis of microtubule self-assembly kinetics and tip structure
Biochemical reconstitution of the WAVE regulatory complex
Rotational movement of formins evaluated by using single-molecule fluorescence polarization
Single-molecule studies of actin assembly and disassembly factors
Assaying microtubule nucleation of the [gamma]-Tubulin ring complex
Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins
Generation of differentially modified microtubules using In Vitro enzymatic approaches
Engineering defined motor ensembles with DNA origami
Construction and analyses of elastically coupled multiple-motor systems
Reconstitution of cortical dynein function
Reconstitution of microtubule-dependent organnelle transport
Reconstituting the motility of isolated intracellular cargoes
Reconstitution of contractile actomyosin arrays
Directed actin assembly and motility
In Vitro reconstitution of dynamic microtubules interacting with actin filament networks
Measuring kinetochore-microtubule interaction In Vitro
Micropattern-guided assembly of overlapping pairs of dynamic microtubules
WAVE regulatory complex activation
Dissecting principles governing actin assembly using yeast extracts
Xenopus egg ctyoplasm with intact actin
Glycogen-supplemented mitotic cytosol for analyzing xenopus egg microtubule organization
Spindle assembly on immmobilized chromatin micropatterns.Digital Access ScienceDirect 2014 - DigitalGhassan Soleiman Abu-Sittah, Jamal J. Hoballah, Joseph Bakhach, editors.Digital Access Springer 2017
- Digital[edited by] Philip H. Zeplin.Contents:
Fundamentals and principles
Techniques
Genital surgery in children
Functional and aesthetic genital surgery in the female
Functional and aesthetic genital surgery in the male
Transsexualism.Digital Access - DigitalHilko Weerda.Summary: Drawing on decades of operating room and teaching experience, Dr. Weerda and his team offer a complete guide to reconstructive options for facial, head, and neck defects in this eagerly awaited second edition. Their systematic, step-by-step approach, with an emphasis on meticulous preoperative planning, evaluation of alternatives, and selection of the best procedure, ensures optimal results for all patients. Focusing on the questions, problems, and technical solutions most commonly encountered in everyday practice, this compact book will be valuable to both the novice and more experienced su.
Contents:
Reconstructive Facial Plastic Surgery: A Problem-Solving Manual; Title Page; Copyright; Contents; Foreword to the 2nd Edition; Foreword to the First Edition; Preface to the 2nd Edition; Contributors; I Anatomy, Principles of Facial Surgery, and Coverage of Defects; 1 Anatomy of the Skin and Skin Flaps; The Skin (Fig. 1.1); Types of Skin Flaps; Random Pattern Flaps (Fig. 1.2); Axial Pattern Flaps (Fig. 1.3); Island Flaps (Fig. 1.4); Myocutaneous Island Flaps (Fig. 1.5; see also Fig. 12.1); Neurovascular Island Flaps; 2 Basic Principles of Facial Surgery; Suture Materials and Techniques. Basic Instrument Set for Reconstructive Facial Plastic Surgery (Fig. 2.7)The Binocular Loupe (Fig. 2.7c); Additional instruments; Wound Management, Repair of Small Defects, and Scar Revision; Relaxed Skin Tension Lines, Vascular Supply (Fig. 2.8i), and "Esthetic Units" (Fig. 2.20); Wound Management, Repair of Small Defects, and Scar Revision; Management of Wounds with Traumatic Tattooing; Scar Revision by W-Plasty and the Broken-Line Technique of Webster (1969) (Fig. 2.8a-j); Small Excisions; Z-Plasty (Figs. 2.15 and 2.16); Postoperative Treatment of Scars. Esthetic Units of the Face (Fig. 2.20)Tumor Resection with Histologic Control (Fig. 2.21); Free Skin Grafts (Fig. 2.22); Composite Grafts (Fig. 2.23); Cartilagenous and Composite Grafts for Auricular and Nasal Reconstruction; Graft Nomenclature; 3 Coverage of Defects; Local Flaps; Advancement Flaps; Advancement Flap of Burow (1855) (Fig. 3.1); Burow's U-Advancement (Figs. 3.2-3.7); V-Y and V-Y-S Advancement of Argamaso (1974) (Figs. 3.8-3.10); Flaps without Continous Epithelial Coverage (Rettinger 1996a, b); Sliding Flap (Figs. 3.11-3.14); Pedicled Flaps; Transposition Flap (Fig. 3.15). Rotation Flap (Fig. 3.19)Bilobed Flap (Fig. 3.22); Rhomboid Flap (Figs. 3.24-3.27); Turnover Flap (Fig. 3.28); Tubed Pedicle Flap (Bipedicle Flap) (Fig. 3.29); Distant Flaps; Distant Tubed Pedicle Flap; Myocutaneous and Myofascial Flaps (see Figs. 12.1-12.3); Special Part; II Coverage of Defects in Specific Facial Regions; 4 Forehead Region; Median Forehead Region; Wedge-Shaped Defects (Fig. 4.1); H-Flap (Fig. 4.2); Double Rotation Flap (Fig. 4.3); Lateral Forehead Defects (Fig. 4.5); 5 Nasal Region; Glabella and Nasal Root (Figs. 5.1-5.9); U-Advancement Flap of Burow (Fig. 5.1). V-Y Advancement (Fig. 5.2 see also Figs. 3.8-3.10); Sliding Flap (Fig. 5.7); Nasal Dorsum (Figs. 5.8-5.12); Bilobed Flap (Fig. 5.8); Island Flap (Fig. 5.9); Rieger Flap (Fig. 5.10); Nasolabial Flap (Fig. 5.11); Median Forehead Flap (Fig. 5.12); Nasal Tip (Figs. 5.13-5.17); Bilobed Flap (Fig. 5.13); V-Y Advancement Flap of Rieger (1957) (Fig. 5.14); Median and Paramedian Forehead Flap (Fig. 5.15); Larger Defects of the Nasal Tip and Ala; Frontotemporal Flap of Schmid and Meyer (Figs. 5.17 and 5.18); Nasal Flank; Flap Advancement of Burow (1855) (Fig. 5.22).Digital Access - DigitalMark S. Myerson, Anish R. Kadakia.Contents:
Chevron osteotomy
The lapidus procedure
Proximal phalangeal osteotomy (akin)
Management of complications after correction of hallux valgus
Hallux varus
Hallux rigidus-joint-sparing techniques
Correction of lesser toe deformity
Correction of crossover toe deformity
Management of metatarsalgia
Surgery for the neuropathic foot and ankle
Cavus foot correction
Tendon transfers for management of paralytic deformity
Correction of flatfoot deformity in the child
Correction of flatfoot deformity in the adult
Complications of treatment of flatfoot
The use of bulk fresh osteoarticular allografts in ankle reconstruction
Reconstruction of malunited ankle fractures
Total ankle replacement
Revision total ankle replacement
Osteotomy of the tibia and fibula
Disorders of the achilles tendon
Rupture of the anterior tibial tendon
Peroneal tendon injury and repair
Tarsal coalition
Tarsal coalition
Ankle instability and impingement syndromes
Management of osteochondral lesions of the talus
Arthrodesis of the hallux metatarsophalangeal and interphalangeal joints
Arthrodesis of the tarsometatarsal joint
Subtalar arthrodesis
Triple arthrodesis
Ankle arthrodesis
Tibiotalocalcaneal and pantalar arthrodesis.Digital Access - Digital[edited by] Darren L. Johnson.Digital Access
- DigitalRuediger G.H. BaumeisterContents:
Pathophysiology of lymphedemas with respect to surgery
Experimental basis of reconstructive lymphovascular surgery
Reconstructive lymphovascular techniques
Objectification of the Results
Results of reconstructive lymphovascular surgery
Reconstructive lymphovascular surgery and other lymphedema treating modalities.Digital Access Springer 2017 - Digital[edited by] Robert X Murphy, Charles K. Herman.Summary: "Reconstructive Plastic Surgery: An Atlas of Essential Procedures edited by esteemed authors, educators, and surgeons Robert X. Murphy Jr. and Charles K. Herman is a comprehensive resource detailing head-to-toe surgical procedures for a broad range of conditions. The senior editors have more than 50 years of collective surgical experience and expertise training hundreds of medical students and plastic surgery residents. A distinguished and diverse group of contributors from more than 15 countries and five continents share clinical pearls throughout the book. Sixty-seven chapters organized in five sections start with head and neck chapters detailing cleft palate defects and repair, followed by functional rhinoplasty, neoplasms, and trauma. Section two encompasses breast reduction/ reconstruction techniques and other breast deformities; and management of trunk ulcers, deep wounds, and defects. The hand and upper extremity section details reconstructive techniques for infections, trauma, and Dupuytren's contracture. The final two sections cover a wide spectrum of nerve-related conditions and syndromes, followed by burns, melanoma, and vascular anomalies"-- Provided by publisher.Digital Access
- DigitalSalah Rubayi ; with contributions by Burl R. Wagenheim and Alicia Mcleland.Digital Access Springer 2015
- DigitalMatthew M. Hanasono, Geoffrey L. Robb, Roman J. Skoracki, Peirong Yu.Digital Access
- DigitalGünter Germann, L. Scott Levin, Randolph Sherman ; illustrator Amanda Tomasikiewicz.Digital Access Thieme MedOne Plastic Surgery 2018
- DigitalBernardo Carpiniello, Antonio Vita, Claudio Mencacci, editors.Summary: The book provides a clear and comprehensive description of both personal and clinical recovery in severe mental disorders, including schizophrenia and related disorders, and mood disorders such as major depression and bipolar disorders. Divided into two main parts: recovery in schizophrenia and related disorders, and recovery in mood disorders, it offers a broad overview of the factors associated with better or worse outcomes in terms of recovery, as well as the rates (how many people affected by mental disorders may gain recovery), and the time course (how long people affected by mental disorders take to recover) of recovery. It also discusses in detail the pharmacological and psychosocial interventions that can be considered recovery-oriented. Covering the main aspects of recovery in major mental disorders, the book is intended for professionals, scholars, students and anyone interested in mental health.
Contents:
Part 1. Recovery in schizophrenia and related disorders
1. Dimensions and Course of Clinical Recovery in Schizophrenia and related disorders
2. Determinants of clinical recovery in schizophrenia
3. Personal recovery in Schizophrenia: a narrative review
4. Personal Recovery within forensic settings
5. Stigma And Attitude Towards Personal Recovery From Mental Illness Amongst Italian Mental Health Professionals
6. Psychosocial Recovery-Oriented Interventions In Schizophrenia
7. Recovery from Psychosis: Emerging definitions, research and select clinical application
8. Treatments and recovery to enhance employment outcomes for people with schizophrenia and other major mental disorders: An innovative clinical and organizational model of work inclusion in Milan and surrounding area
9. Recovery oriented psychopharmacological interventions in Schizophrenia
Part 2. Recovery in mood disorders
10. Predictors of clinical recovery in bipolar disorders
11. Psychosocial recovery-oriented treatments in Bipolar Disorders
12. Psychopharmacological recovery-oriented treatments in Bipolar Disorders
13. Dimensions and predictors of personal recovery in Major Depression
14. Recovery-oriented treatments in major depressive disorder. - DigitalDeborah Wallace, Rodrick Wallace.Summary: As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its predecessor, the sequel examines the vulnerabilities that give rise to spikes in infection rates that form epicenters. Unlike the first wave, NYC was not the epicenter of the second wave; high-incident counties just outside NYS formed an extended initial epicenter and exported COVID-19 to neighboring counties of NYS. Rural NYS counties differed significantly from urban ones socioeconomically and in infection rates during the cresting period. Before the crest, no socioeconomic factor was associated with county infection rates; rather, the major associating factor was political and cultural: percent of the 2020 vote garnered by Trump. Rural counties voted heavily for Trump. This association disappeared post-crest by mid-January 2021. In NYC, the Bronx again behaved like a single high-incidence entity, unlike the other three boroughs that had patches of high and low infection incidence. Among the topics covered: The Second COVID Wave Washes Over New York State The Second Wave Storm-Surges Across New York City Discussion of County Data from the Second Wave of COVID-19 Parsing Meaning From the 152 ZIP Code Data The book closes with a prescription for pandemic response planning based on empowered communities and workers interacting with health departments as equals. The Recurrence of COVID-19 in New York State and New York City is a valuable resource for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also will find readership among students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
Contents:
Chapter 1. The Sixty-Two Counties of New York State
Chapter 2. The Second COVID Wave Washes over New York State
Chapter 3. Socioeconomic/Demographic Context of the Big Apple’s Four Main Boroughs
Chapter 4. The Second Wave Storm-Surges Across New York City
Chapter 5. Discussion of County Data from the Second Wave of COVID-19
Chapter 6. Parsing Meaning from the 152 ZIP Code Data
Chapter 7. What Is to Be Done?. - DigitalGregory W. Randolph, editor.Contents:
Rates of RLN and SLN injury
Data from National Quality Registries and the literature
Laryngeal Exan Indications and Techniques
Neurologic Control of the Larynx
Micro-neuroanatomy of the Vagus, Superior Laryngeal, and Recurrent Laryngeal Nerves
Intralaryngeal anatomy of the recurrent laryngeal nerve
Imaging of the Recurrent Laryngeal Nerve
RLN Nerve and Inferior Thyroid Crossing
Recurrent Laryngeal Nerve Branching
The Recurrent Laryngeal Nerve and the Tubercle of Zuckerkandl
The Ligament of Berry
The Non-recurrent inferior laryngeal nerve
The Boston RLN anatomic classification system
Surgical Approaches to the Recurrent Laryngeal Nerve
IONM of the Recurrent Laryngeal Nerve
Continuous Intraoperative Neuromonitoring (CIONM) of the Recurrent Laryngeal Nerve
External Branch of Superior Laryngeal Nerve (EBSLN) Anatomic Classification
Surgical approach and monitoring of the External Branch of the Super Laryngeal Nerve (EBSLN)
Loss of signal in IONM and staged thyroid surgery
Mechanism of Injury
Intraoperative Neural Injury Management: Neuropraxic Non-Transection Injury
Intraoperative Nerve Injury Management
Transection and Segmental Defects
Nerve Management: Invasive Disease
Postoperative Management of Unilateral RLN Paralysis
Postoperative management of bilateral vocal cord paralysis
The recurrent laryngeal nerve and medical malpractice during thyroid surgery
Postoperative Management of Superior Laryngeal Nerve Paralysis.Digital Access Springer 2016 - DigitalHelena M. Tabery.Summary: This book on the morphology of corneal surface changes in recurrent erosion syndrome and epithelial edema presents high-magnification images captured in vivo by the method of non-contact photomicrography. Part I of the book, on recurrent erosion syndrome, displays images covering a broad spectrum of epithelial changes, including manifestations of the ongoing underlying pathological process and epithelial activity aimed at elimination of abnormal elements and repair. The dynamics of the interplay between these opposing forces are captured in sequential photographs that are invaluable for interpretation. Case reports illustrate typical features of the disease and document the variability of symptoms and findings in the same individual over time. Also included are images of the appearance and dynamics of corneal stromal infiltrates, a rare but potentially sight-threatening complication. Part II of the book demonstrates typical features of corneal epithelial edema and also covers the occasional contemporaneous occurrence, and dynamics, of various phenomena indistinguishable from those commonly seen in recurrent erosion syndrome. Again, informative case reports are included. The in vivo images displayed in this book, obtained at a higher magnification than that used in standard photography, reveal additional details of epithelial changes. The presented morphology will facilitate understanding of clinical appearances and assist in differential diagnosis.
Contents:
CORNEAL RECURRENT EROSION SYNDROME: The Morphology of Recurrent Erosions
Case Reports
Recurrent Erosions and Stromal Infiltrates. CORNEAL EPITHELIAL EDEMA: The Morphology of Epithelial Edema
Case Reports. Final Remarks. - Printedited by Howard Carp.Contents:
List of contributors
Preface
Part I : Basic Principles
1 The Epidemiology of Recurrent Pregnancy Loss
Ole B. Christiansen
2 The signaling between embryo and mother as a basis for the development of tolerance
Eytan R. Barnea
3 Recurrent Pregnancy Loss: From Evidence Based to Personalised Medicine Howard J.A. Carp
Part II : Etiology
4 The genetics of spontaneous abortions
Joe Leigh Simpson
5 The endometrial factor in Recurrent Pregnancy Loss
Luiza Borges Manna and Ying Cheong
6 Fetal Structural Malformations and Recurrent Pregnancy Loss
Howard J.A. Carp, Tomas Philipp, Micha Baum, and Michal Berkenstadt
7 The endocrinology of Recurrent Pregnancy Loss
Nicola Pluchinoi, Serena Bellaminutti, Panagiotis Drakopoulos,
Antonis Makrigiannakis, and Andrea R Genazzani
8 The etiology of the Antiphospholipid syndrome
Sara De Carolis, Giuseppina Monteleone, Rotem Inbar, Miri Blank, and Yehuda Shoenfeld
9 Defects in coagulation factors leading to recurrent pregnancy loss
Aida Inbal and Howard J.A. Carp
10 The immunobiology of recurrent miscarriage
Marighoula Varla-Leftherioti. Theodora Keramitsoglou, Barbara Geladakis, and Christina Tsekoura
11 Immune testing in Recurrent Pregnancy Loss
Jeffrey Braverman, Darren Ritsick, and Nadera Mansouri-Attia
12 Uterine anomalies and recurrent pregnancy loss
Daniel S. Seidman and Mordechai Goldenberg
13 The Male Factor in Recurrent Pregnancy Loss
Catherine F. Ingram, Nannan Thirumavalavan, Marc Goldstein, and
Delores J. Lamb
Part III : The Developing Pregnancy
14 Ultrasound follow up in Early Pregnancy
Akhila Vasudeva and Pratap Kumar
15 Threatened miscarriage and Recurrent Pregnancy Loss
Howard J.A. Carp
16 The Role of Cerclage and Pessaries
Israel Hendler and Howard J.A. Carp
17 What genetic screening is appropriate in Recurrent Pregnancy Loss?
Howard Cuckle
18 Obstetric Outcomes after Recurrent Pregnancy Loss
Rakefet Yoeli, Howard J.A. Carp, and Shali Mazaki-Tovi
Part IV : Management
19 Investigation protocol for recurrent pregnancy loss
Howard J.A. Carp
20 Debate: Should Progestogen supplementation be used in Recurrent Pregnancy Loss? Yes
Ashok Kumar and Simar Kaur
21 Debate: Should Progestogen supplementation be used in Recurrent Pregnancy Loss? No
Roy Mashiach, Aisha Hameed, Shazia Malik, and Lesley Regan
22 hCG supplementation in Recurrent Pregnancy Loss
Carlo Ticconi, Adalgisa Pietropolli, and C.V. Rao
23 Antiphospholipid Syndrome: Management of the Obstetric Patient
Ashley E. Benson and D. Ware Branch
24 Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents?
Audrey A. Merriam and Michael J. Paidas
25 Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is it a valid concept?
Michal Kirshenbam and Raoul Orvieto
26 Debate: Should PGT-A still be performed in Recurrent Pregnancy Loss? Yes
Carmen M. Garcia-Pascual, Pilar Lopez, Nasser Al-Asmar, Pere Mir, Lorena Rodrigo, Carlos Simon, and Carmen Rubio
27 Debate: Should PGT-A still be performed in Recurrent Pregnancy Loss? No
Raoul Orvieto and Norbert Gleicher
28 Third Party Reproduction in Recurrent Pregnancy Loss
Gautam Nand Allahbadia, Rubina Merchant, Akanksha Allahbadia Gupta, and Maham AH
Part V : Immunotherapy
29 Immunotherapy for Recurrent Pregnancy Loss
Salim Daya
30 IVIg treatment for Recurrent Pregnancy Loss
Carolyn B. Coulam
31 The role of filgrastrim
Fabio Scarpellini and Marco Sbracia
32 Opinion: Immunotherapy has no place in the treatment of Recurrent Pregnancy
Loss
Micha Baum and Raj Rai
Index. - DigitalAsher Bashiri, Avi Harlev, Ashok Agarwal, editors.Contents:
Part I: Introduction to Recurrent Pregnancy Loss
Recurrent pregnancy loss: definitions, epidemiology, and prognosis
Implantation, Physiology of Placentation
Part II: Causes of Recurrent Pregnancy Loss
Endocrine abnormalities in RPL
Genetics of recurrent pregnancy loss
Inherited and Acquired Thrombophilias and Adverse Pregnancy Outcomes
Immunological causes of recurrent pregnancy loss
Anatomical aspects in recurrent pregnancy loss
Male Factors in Recurrent Pregnancy Loss
Lifestyle and RPL
The common characteristics between Infertility and recurrent pregnancy loss
Part III: Management of Recurrent Pregnancy Loss. Contemporary Prevention and treatment of recurrent pregnancy loss
Part IV: Psychological and Supporting Aspects of Recurrent Pregnancy Loss
The healthcare giver's perspective
The importance of emotional support for women with recurrent RPL
A Patient's Perspective
Part V: The Future
New Frontiers in RPL research and treatment. - PrintJacqueline Woodson.Summary: Two families from different social classes are joined together by an unexpected pregnancy and the child that it produces. Moving forward and backward in time, with the power of poetry and the emotional richness of a narrative ten times its length, Jacqueline Woodson's extraordinary new nove uncovers the role that history and community have played in the experiences, decisions, and relationships of these families and in the life of this child. As the book open in 2001, it is the evening of sixteen-year-old Melody's coming-of-age ceremony in her grandparents' Brooklyn brownstone. Watched lovingly by her relatives and friends, making her entrance to the soundtrack of Prince, she wears a special custom-made dress. But the event is not without poignancy. Sixteen years earlier, that very dress was measured and sewn for a different wearer: Melody's mother, for her own ceremony - a celebration that ultimately never took place. Unfurling the history of Melody's parents and grandparents to show how they all arrived at this moment, Woodson considers not just their ambitions and successes but also the costs, the tolls they'e paid for striving to overcome expectations and escape the pull of history. As it explores sexual desire and identity, ambition, gentrification, education, class and status, and the life-altering facts of parenthood, Red at the Bone most strikingly looks at the ways in which young people must so often make long-lasting decisions about their lives - even before they have begun to figure out who they are and what they want to be. -- From dust jacket.
- Digital/PrintSummary: Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.Digital Access Silverchair 1970-Latest ed. only
- Digitaledited by David W. Kimberlin, MD, FAAPSummary: Fully revised and updated, the second edition of this full-color chart collects many of the most clinically useful tables, algorithms, and other items from the Red Book and presents them in an enlarged, enhanced, colorized format that is lightweight, portable, and easy to navigateDigital Access AAP ebooks 2021
- Digitaledited by Tina Q. Tan.Summary: "The fifth edition of this best-selling Red Book image companion aids in the diagnosis and treatment of more than 165 pediatric infectious diseases. Streamline disease recognition and clinical decision-making with more than 1,350 finely detailed color images, combined with step-by-step guidance" -- Publisher's description.Digital Access AAP ebooks 2023
- Digital/PrintSummary: Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.Digital Access Silverchair 1970-Latest ed. only
- Digitaleditor, David W. Kimberlin, MD, FAAP.Summary: This convenient flip chart provides pediatric health care professionals with point-of-care guidance on the assessment, prevention, and treatment of childhood infectious diseases. The content featured in these 15 information-rich tabs collects many of the most clinically useful tables, algorithms, and other items from the Red Book and presents them in an enlarged, enhanced, colorized format that is lightweight, portable, and easy to navigate.
Contents:
Intro; Contents; Staphylococcal Infections; Streptococcal Infections; Diarrheal Infections; Immunizations; Antibiotic Prophylaxis; Immune Globulin; Kawasaki Disease; Tuberculosis; Lyme Disease; Varicella-Zoster; Zika; Fungal Infections; Genital and Neonatal Herpes; Syphilis; Immunocompromised Children and Adolescents.Digital Access AAP ebooks 2019 - DigitalSue Greenhalgh, James Selfe.Contents:
Foreword
Acknowledgements
1. Introduction
2. Communication
3. Osteoporosis : Diagnosis
4. Osteoporosis : Consequences and Care
5. Cauda Equina Syndrome : Diagnosis
6. Cauda Equina Syndrome : Consequences and Care
7. Metastatic Spinal Cord Compression (MSCC)
8. Metastatic Spinal Cord Compression (MSCC) : Consequences and Care.Digital Access ClinicalKey Nursing 2019 - DigitalT. Pullaiah, S. Balasubramanya, M. Anuradha, editors.Summary: Pterocarpus santalinus L.f., popularly known as Red Sanders, an endemic tree, belonging to the family Fabaceae is confined to the southern parts of Eastern Ghats. IUCN has listed this tree as endangered. The plant has superlative characteristics in its wood and has many medicinal properties. This plant has attracted the attention of both foresters and lay man because of its high valued wood which is being illegally harvested creating law and order problem. This book is a comprehensive monograph on Red Sanders and is divided into 15 chapters. The book provides information on taxonomy, morphology, distribution, wood anatomy, wood properties and uses, dye principle, phytochemistry, pharmacology, Silvicultural aspects, propagation, cultivation practices, reproductive biology, pests and diseases, biotechnology, molecular studies, conservation, trade, commerce, socioeconomic aspects of Red Sanders, and grey areas of research. The book is profusely illustrated with colour photographs and line drawings. Relevant references have been provided under each chapter. This monograph on Red Sanders with systematic representation of information and illustrations will be a desk reference and field guide to foresters, botanists, researchers, farmers, traders and environmentalists.
Contents:
Chapter 1 Introduction
Red Sanders: An Endemic and Endangered Tree Chapter 2 Taxonomy and Distribution Chapter 3 Wood Uses, Ethnobotany and Pharmacognosy Chapter 4 Chemistry of Red Sanders Chapter 5 Coloring Principle (Dye) Chapter 6 Pharmacology of Red Sanders Chapter 7 Reproductive Biology Chapter 8 Propagation of Red sanders: An overview Chapter 9 Silviculture of Pterocarpus santalinus Chapter 10. Pests and Diseases of Pterocarpus santalinus Chapter 11 Wood Anatomy and Wood Property Variation in Red Sanders Chapter 12 Red Sanders : Threats and Conservation Chapter 13. Genetic Diversity and Conservation of Pterocarpus santalinus L. through Molecular Approaches Chapter 14. Trade, commerce and socio-economic status of Red sanders Chapter 15. Tree Improvement in Red Sanders. - PrintJanet Mock.Summary: "In a landmark book, an extraordinary young woman recounts her coming-of-age as a transgender teen--a deeply personal and empowering portrait of self-revelation, adversity, and heroism. In 2011, Marie Claire magazine published a profile of Janet Mock in which she publicly stepped forward for the first time as a trans woman. Since then, Mock has gone from covering the red carpet for People.com to advocating for all those who live within the shadows of society. Redefining Realness offers a bold new perspective on being young, multiracial, economically challenged, and transgender in America. Welcomed into the world as her parents' firstborn son, Mock set out early on to be her own person--no simple feat for a young person like herself. She struggled as the smart, determined child in a deeply loving, yet ill-equipped family that lacked money, education, and resources. Mock had to navigate her way through her teen years without parental guidance but luckily with a few close friends and mentors she overcame extremely daunting hurdles. This powerful memoir follows Mock's quest for identity, from her early gender conviction to a turbulent adolescence in Honolulu that found her transitioning through the halls of her school, self-medicating with hormones at fifteen, and flying across the world for sex reassignment surgery at just eighteen. Ever resilient, Mock emerged with a scholarship to college and moved to New York City, where she earned her masters degree, basked in the success of an enviable career, and told no one about her past. It wasn't until Mock fell for a man who called her the woman of his dreams that she felt ready to finally tell her story, becoming a fierce advocate for girls like herself. A profound statement of affirmation from a courageous woman, Redefining Realness shows as never before what it means to be a woman today and how to be yourself when you don't fit the mold created for you."
- DigitalJohn T. Tanacredi.Summary: This book provides insight into the basic aspects of ecology that impact or are affected by engineering practices. Ecological principals are described and discussed through the lens of the influences that built structures have on the Earth's biological, geological, and chemical systems. The text goes on to elucidate the engineering influences that have or will influence the face of the Earth. These influences redesign the Earth, either by destroying natural systems and replacing them with highly subsidized systems or by attempting to restore highly disturbed or contaminated systems with the basic natural systems that were originally present.
Contents:
Ecology: Principles of Life: It's Not Just About You, You Know!
Preserving Biological Diversity: Engineers Need An Earth Ethic Also!
Ecotoxicology: Chickens Have Lips Don't They?
Genetic Engineering: Don't Dust off the Slide Ruler Just Yet
Sanitary Microbiology: Engineering Public Health Better Than the 'Good Ol' Days!'
Marine and Estuarine Ecology-Our Oceans as the Last Frontier on Earth!
Terrestrial Ecology-Restoration Is the Only Answer
Limnological Systems-Dam Dams!
Ecological Risk Assessment: Gordian Knots Untied
Environmental Law: The Only Good Lawyer is a ____
Coastal Ecosystem Restoration: Pride and Practice with No Follow-up!- Case Studies: Can we learn from past experiences? Or, Win Some, Loose Some, In the End there is No Free Lunch!
Case Study 1. Laughing Gulls and Airports: "They Shoot Gulls, Don't They?"
Case Study 2. Bridges
Delaware Bridge Toll Authority and North Channel Bridge Jamaica Bay: Troubled Bridges Over Water
Case Study 3. Gowanus Canal Restoration: Pig Skin Purse with a Silk Lining
Case Study 4. Sandy Hook Restoration- Beach Replenishment (Coastal Erosion and Recreation!)
Case Study 5. Vandalia Dunes and Estates
Inner City Sprawl and We Love It! - DigitalAbley, Clare; Fitzpatrick, Joanne; Harris, Ruth; Ross, Fiona.Digital Access ClinicalKey Nursing 2024
- DigitalRomesh Kumar Salgotra, Sajad Majeed Zargar, editors.Summary: This book describes how the latest genomic resources techniques can be efficiently used in plant breeding programmes to achieve food security in the future. It also shares insights on how to utilize the untapped and unexplored genetic diversity of wild species, wild relatives and landraces for crop improvement. Moreover, the book offers an impressive array of balanced analyses, fresh ideas and perspectives, and thoughtful and realistic proposals regarding the sustainable utilization of plant genetic resources with modern biotechnological techniques. The first book to address the importance of plant genetics and genomic resources for food security, it brings together a group of plant breeders and biotechnologists to investigate the use of genomic resources techniques in plant breeding programmes. Providing essential information on the efficient utilization of genomic resources in precision breeding, it offers a valuable asset for undergraduate and graduate students, teachers and professionals engaged in related fields.
Contents:
Chapter 1 Potential of genetic and genomic resources for genetic improvement of food crops
Chapter 2 Untapped genetic diversity of wild relatives for crop improvement
Chapter 3 Molecular approaches for harvesting natural diversity for crop improvement
Chapter 4 Omics and plant genetic resources: Towards mining potential genes
Chapter 5 Genetic and genomic resources and their exploitation for unlocking genetic potential from the wild relatives.-Chapter 6 Role of gene banks in maintaining crop genetic resources
Chapter 7 Exploring genetic resources for identification of potential novel genes for crop improvement
Chapter 8 Next-generation sequencing technologies and their implications for efficiently utilization of genetic resources
Chapter 9 Comparative genomics for exploring new genes and traits for crop improvement
Chapter 10 Potential of wild species in the scenario of climate change
Chapter 11 Role of wild relatives for development of climate-resilient varieties
Chapter 12 Strategies for conservation of genetic resources
Chapter 13 Crop landraces: Present threats and opportunities for conservation
Chapter 14 Future threats and opportunities facing crop wild relatives and landrace diversity. - Digitaledited by Danyelle M. Townsend, Kenneth D. Tew.Contents:
Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz
Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki
Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan
Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend
A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper
Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik
Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang
Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.Digital Access ScienceDirect 2014 - DigitalSanjib Kumar Panda, Yoshiharu Y. Yamamoto, editors.Summary: This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.
Contents:
Redox regulation of proteins
Advances in Chlorophyll Fluorescence Theories: Close Investigation into Oxidative Stress and Potential Use for Plant Breeding
ROS and Fe homeostasis in Plants
Hydrogen peroxide as a signaling molecule for broad stress responses
Ascorbate Peroxidases: Scavengers or sensors of hydrogen peroxide Signaling
Redox Homeostasis in Plants under Arsenic Stress
Role of reactive oxygen species homeostasis in root development and rhizotoxicity in plants
microRNAs-mediated redox homeostasis in plants under oxidative stress
A review on water stress and redox regulation with emphasis on future biotechnological prospects
Interactions between circadian rhythms, ROS and redox
ROS and Heat stress. - DigitalToshiyuki Mori, Giovanni Dapri, editors.Summary: Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments. Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.
Contents:
History of Singl-Port Laparoscopic Surgery
Concept of Reduced Port Laparoscopic Surgery
Terminology
Pros and Cons
Access Device 1: Multiple Trocars Method
Access Device 2: Multi-Channel Port
Video-Endoscopes and Instruments
Needlescopic Devices and Pre-bent Forceps
Different Tools
Technical Considerations
Suturing and Knot-Tying Technique
Single-Incision Robotic Surgery
The Umbilicus as the Access Site
Cholecystectomy
Cholecystectomy with Improved Retraction
Common Bile Duct Exploration
Distal Gastrectomy
Total Gastrectomy
Wedge Gastric and Endo-Gastric Resection
Antireflux Procedures
Hepatectomy
Splenectomy
Distal Pancreatectomy
Pancreatico-Jejunostomy
Adrenalectomy
Right Colectomy
Left Colectomy
Anterior Resection of the Rectum
Appendectomy
Incisional and Ventral Hernia Repair
Inguinal Hernia Repair: TEP
Inguinal Hernia Repair: TAPP
Adjustable Gastric Banding for Obesity
Roux-en-Y Gastric Bypass for Obesity
Sleeve Gastrectomy for Obesity
Gastric Plication for Obesity
Malabsorptive and Mixed Procedures for Obesity
Revisional Obesity Surgery
Two or Combined Procedures
Urology
Gynecology
Breast Surgery
Pediatric Surgery. - Digitaledited by David G. Allen and Michael D. Waters.Summary: Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.Digital Access R Soc Chem 2013
- DigitalMarilyn Campbell, Sheri Bauman.Summary: Reducing Cyberbullying in Schools: International Evidence-Based Best Practices provides an accessible blend of academic rigor and practical application for mental health professionals, school administrators and educators, giving them a vital tool in stemming the problem of cyberbullying in school settings. It features a variety of international, evidence-based programs that can be practically implemented into any school setting. In addition, the book looks at a broad array of strategies, such as what can be learned from traditional bullying programs, technological solutions, policy and legal solutions, and more.Digital Access ScienceDirect 2018
- DigitalGiovanni Landoni, Marta Mucchetti, Alberto Zangrillo, Rinaldo Bellomo, editors.Digital Access Springer 2015
- DigitalGiovanni Landoni, Martina Baiardo Redaelli, Chiara Sartini, Alberto Zangrillo, Rinaldo Bellomo, editors.Summary: The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.
Contents:
The process of consensus building
Non-invasive ventilation
High Flow Nasal Cannulae
Restrictive inspiratory oxygen fraction
Mechanical ventilation
Early tracheostomy
Pharmacological Managment of cardiac arrest
Non pharmacological Managment of cardiac arrest
Avoidance of deep sedation
Hydrocortisone in sepsis; Goal directed therapy
Levosimendan in cardiogenic shock and low cardiac output syndrome
Drugs in myocardial infarction
Tranexamic acid in trauma patients
Procalcitonin-guided antibiotic discontinuation
Selective decontamination of digestive tract
Nutrition
ECMO
Ultrasound
Alternative medicine
Interventions increasing mortality
Conflicting
Latest evidences. - DigitalGiovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.Summary: This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists.
Contents:
The risks and benefits of the consensus process
The process of consensus building
Noninvasive Ventilation to reduce perioperative mortality
Role of inhalational anesthetic agents in reducing perioperative mortality
Can Neuraxial Anesthesia Reduce Perioperative Mortality
Role of perioperative hemodynamic optimization in reducing perioperative mortality
Levosimendan to reduce perioperative mortality
Could Clonidine Contribute to a Reduction in Perioperative Mortality
Perioperative [beta]-blocker therapy to improve survival
Perioperative supplemental oxygen to reduce perioperative mortality
Leukocyte depletion of transfused blood to reduce perioperative mortality
Chlorhexidine Oral Rinse to reduce perioperative mortality
Reducing perioperative mortality with Intra Aortic Balloon Counterpulsation (IABP)
Selective Decontamination of the Digestive Tract
Role of insulin in reducing mortality in the perioperative period
Aprotinin: pharmacological benefits and safety concerns
Consensus Conference on perioperative mortality: an update. - DigitalGiovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.Contents:
The Risks and Benefits of the Consensus Process
The Process of Consensus Building
Noninvasive Ventilation to Reduce Perioperative Mortality
Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality
Can Neuraxial Anesthesia Reduce Perioperative Mortality
Role of Perioperative Hemodynamic Optimization in Reducing Perioperative Mortality
Levosimendan to Reduce Perioperative Mortality
Perioperative b-Blocker Therapy and Survival
Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality
Reducing Perioperative Mortality with Intra-Aortic Balloon Counterpulsation (IABP)
Selective Decontamination of the Digestive Tract
Role of Insulin in Reducing Mortality in the Perioperative Period
Aprotinin: Pharmacological Benefits and Safety Concerns
Consensus Conference on Perioperative Mortality: An Update
Liberal Transfusion Strategy in the Perioperative Period
Remote ischaemic preconditioning
Statins
Tranexamic acid
Proven mortality reduction unconfirmed in most recent works. methodological problem.Digital Access Springer 2017 - DigitalRaj Mathur, editor.Contents:
1. The Challenges of Multiple Pregnancies
2. Prognosis of Risks for Offspring of Fertility Treatment
3. Ovarian Hyperstimulation Syndrome
4. Thromboembolism Associated with Fertility Treatment
5. Emotional and Psychosocial Risk Associated with Fertility Treatment
6. Regulatory and Legal Risks for Patients.Digital Access Springer 2015 - Digital/Printedited by Salvatore Vaccarella [and 5 others].Summary: This volume summarizes the current scientific evidence and identifies research priorities needed to decrease social inequalities in cancer. The publication, based on the expert knowledge of more than 70 international scientists from multiple disciplines, undertakes a populations-within-populations approach, highlighting the large variations in cancer incidence, survival, and mortality that exist between countries and, within countries, between social groups. Several factors may lead individuals with low social status to adopt unhealthy behaviors, to be exposed to a wider range and a higher intensity of cancer risk factors, and to have reduced access to health-care services, compared with their fellow citizens. A special focus is given to how the phenomenon of inequalities in cancer evolves and is reshaped over time, driven by economic, social, political, legislative, and technological forces; it affects everyone, but the most disadvantaged individuals are particularly hard hit. This IARC Scientific Publication was developed to serve as a reference for policy-makers and public health officials, linking to specific examples of interventions that may reduce future inequalities in cancer.Digital Access 2019
- DigitalLamia Soghier, editorSummary: Completely updated, this popular pocket guide provides commonly used reference ranges and values spanning birth through adolescence; plus, data needed for treatment of preterm and other newborns.Digital Access AAP ebooks 2019
- DigitalMarc Maesschalck.Contents:
RRI and Governance Theory
The Origins of Governance Theory
Exploring Reflexive Governance Theory
Key Strengths of a Reflexive Theory of Governance
Promoting Reflexive Governance of RRI
Intellectual Intervention in Society: The Key to Reflexive Governance of RRI.Digital Access Wiley 2017 - DigitalAlyn H. Morice, Peter W. Dettmar, editors.Summary: This book is about the interface between reflux and the respiratory tract. Reflux is an important factor in many different lung diseases. The pathological basis of reflux has recently undergone major changes in our understanding based on improved diagnostic technology. Readers will learn about how reflux impacts on many common lung conditions. Special circumstances such as eosinophilic inflammation in relation to asthma, cough, and eosinophilic bronchitis will be highlighted. Particular attention is also given to previously unrecognised role of non-acid "airway" reflux. Additionally, pharmacological, surgical and behavioural techniques for diagnostic and treatment are explored witin these chapters This book offers a comprehensive overview of various research areas in reflux in relation to airways disease, since currently there is no summary of how the different but overlapping areas impacted by reflux affect the respiratory tract. It will be of great interest to respiratory physicians, otorhinolaryngologists, and gastroenterologists. .
Contents:
Intro; Foreword; Preface; Acknowledgement; Abbreviations; Contents; Part I: Pathology;
1: Diagnostic Confusion Through the Ages; Introduction; True Flatulent Asthma; Page X; Page XXVIII; Page 5; Page 6; Page 9; Page 10; Page 23; Page 176; References;
2: An Overview of Gastroesophageal Reflux Disease; Definition and Clinical Manifestations; Epidemiology; Diagnosis; Proton Pump Inhibitor Trial; Upper Gastrointestinal Endoscopy; Indications for First Upper Gastrointestinal Endoscopy; Indications for Follow-Up Upper Gastrointestinal Endoscopy; 24-h Ambulatory pH or pH-Impedance Monitoring Indications for 24-h Impedance-pH MonitoringWireless pH Monitoring; Oesophageal Manometry; Other Tests; Medical, Endoscopic and Surgical Therapy; Lifestyle Modifications; Medical Therapy; Endoluminal Therapies; Anti-reflux Surgery; Summary of the Therapeutic Approach; Status of Newer Medications; Improved Acid Suppression; Helicobacter pylori and GORD; References;
3: Chemical Composition of Refluxate; Introduction; Overview of Gastric Secretions; Control of Gastric Secretion; The Gastric Microbiome; Refluxate and Other Non-gastric Secretions; Dietary Intake and Reflux; Summary; References
4: Pathological ProcessesPutative Mechanisms for Reflux/Aspiration Leading to Inflammation; Animal Models; Cell Models; Human Studies; Summary; References;
5: Pathophysiology in the Lung; Gastro Oesophageal Reflux and Aspiration Occurs Normally in Humans; Lung Diseases Associated with GOR and Aspiration; Parenchymal Disease (See Also Chap. 16); Airways Disease; COPD; Asthma; Cystic Fibrosis (CF); Non-cystic Fibrosis Bronchiectasis (NCFB); BOS Post Lung Transplantation; The Role of a Mixed Disciplinary Aerodigestive Team Approach; Questions Raised by This Chapter; What Is Normal? The Importance of the MicrobiomeUnderstanding Therapy; Interrelationships Between Lung and Gastrointestinal Pathophysiology: The Chicken and Egg of Reflux and Aspiration; The Role of Surgical Fundoplication; References;
6: Effect of Reflux on Cough Sensitivity and Bronchial Responsiveness; Introduction; Reflux and Cough Reflex Sensitivity; Reflux and Bronchial Responsiveness; References; Part II: Diagnosis;
7: Questionnaire Diagnosis of Airways Reflux; Introduction; Airway Reflux Questionnaires; Reflux Symptom Index (RSI); Supraesophageal Reflux Questionnaire (SERQ) Pharyngeal Reflux Symptom Questionnaire (PRSQ)Hull Airways Reflux Questionnaire (HARQ); Composite Questionnaires; Discussion; References;
8: Pepsin Detection as a Diagnostic Test for Reflux Disease; Introduction; History of Reflux; History of Pepsin; Reflux Diagnostic Tests: Invasive and Non-invasive; Methods; Patient Recruitment; Sample Collection; Pepsin Analysis; Results; Discussion; References;
9: Imaging Reflux; Introduction; X-ray; Nuclear Medicine; Magnetic Resonance Imaging; References;
10: High Resolution Oesophageal Manometry in the Investigation of Unexplained Cough; IntroductionDigital Access Springer 2018 - DigitalVassilios Raikos, Viren Ranawana, editors.Summary: This work introduces the concept of reformulation, a relatively new strategy to develop foods with beneficial properties. Food reformulation by definition is the act of re-designing an existing, often popular, processed food product with the primary objective of making it healthier. In recent years the concept of food reformulation has evolved significantly as additional benefits of re-designing food have become apparent. In addition to targeting specific food ingredients that are considered potentially harmful for human health, food reformulation can also be effectively used as a strategy to make foods more nutritious by introducing essential macro- /micro-nutrients or phytochemicals in the diet. Reformulating foods can also improve sustainability by introducing "waste" (and underutilized) ingredients into the food chain. In light of these developments, reformulating existing foods is now considered a realistic and attractive opportunity to provide healthy, nutritious, and sustainable food choices to the consumers and likewise improve public health. Indeed reformulation has now become essential in many cases for redressing the health properties of foods that are popularly consumed and significantly affecting public health. This edited volume covers aspects of food reformulation from various angles, exploring the role of the food industry, academia, and consumers in developing new products. Some of the major themes contributors address include methods of reformulating food products for health, improving the nutritional composition of foods, and challenges to the food industry, including regulation as well as consumer perception of new products. The book presents several case studies to clarify these objectives and illustrate the difficulties encountered in the process of developing a reformulated product. Chapters from experts in the field identify emerging and future trends in food product development, and highlight ways in which these efforts will help with increasing food security, improving nutrition and health, and promoting sustainable production. The editors have designed the book to be useful for both industry professionals and the research community. This interdisciplinary approach incorporates a wide spectrum of food sciences (including composition, engineering, and chemistry) as well as nutrition and public health. Food and nutrition professionals, policy makers, health care and social scientists, and graduate students will also find the information relevant.
Contents:
Intro; Preface; Acknowledgments; Contents; Contributors; Reformulating Foods for Health-Concepts, Trends and Considerations; References; Reformulation of Foods for Weight Loss: A Focus on Carbohydrates and Fats; 1 Introduction; 2 Reformulation of Carbohydrates; 2.1 Strategies for Carbohydrate Reformulation; 2.1.1 Sugar Reformulation Using Intense Sweeteners; 2.1.2 Sugar Reformulation using Bulk Sweeteners; 2.2 Starch and Sucrose Reformulation using Dietary Fibre; 2.3 Effect of Reformulated Foods with Sweeteners on Weight Loss; 2.4 Effect of Reformulated Foods with Dietary Fibre on Weight Loss 1 Introduction: The Relevance of Nutrient Profiling to Drive (Re)Formulation of Foods and Beverages and the Landscape of Nutrient Profiling Systems Used by the Food Industry2 Requirements of Driving Nutritional Reformulation by the Food Industry; 2.1 Defining Nutritional Reformulation as Company Strategy; 2.2 Setting Tangible Nutritional Targets: Short Description of the Nestlé Nutritional Profiling System (NNPS), Its Key Features, and Development; 2.2.1 Food Category Within Which the Product Sits; 2.2.2 Nutrients to Limit and Nutrients to Encourage Specific to the Food Category 2.1 Digestible and Non-digestible Carbohydrates Are Intimately Associated in Nature2.2 The Relationship of Polysaccharides to Health; 3 Approaching Reformulation; 4 Procedural Components in a Reformulation Strategy; 4.1 Target Health Outcomes; 4.2 Physiological States or Intermediary Processes That Lead to Health Outcomes; 5 Gut-Level Processes that Determine Physiological State; 5.1 Digestion; 5.2 Mixing; 5.3 Diffusion; 6 Examples of Food Properties Affecting Gut-Level Processes in the Foregut; 6.1 Solubility/Insolubility; 6.2 Viscosity; 6.3 Hydration/Concentration 2.5 Limitations in Carbohydrate Reformulation3 Reformulation of Foods to Reduce Fat Content; 3.1 Fat Reduction; 3.2 Strategies for Fat Reformulation; 3.3 Fat Substitutes; 3.3.1 Sucrose Fatty Acid Polyesters; 3.3.2 Medium Chain Triglycerides (MCTs); 3.3.3 Coconut Oil; 3.3.4 Diaclyglycerol; 3.3.5 Small Particle Lipids; 3.4 Fat Mimetics; 3.4.1 Protein-Based Fat Mimetics; 3.4.2 Carbohydrate-Based Fat Mimetics; 4 Conclusion; References; Digestible and Non-digestible Polysaccharide Roles in Reformulating Foods for Health; 1 Introduction; 2 Some Questions Arising 6.4 Polysaccharide-polysaccharide Interaction6.5 Polysaccharide-particle Interactions; 6.6 Particle/Cell Wall/Polymer Integrity; 6.7 Particle Effects on Diffusion; 7 Effects of Food Structure in the Large Bowel; 7.1 Fermentation; 7.2 Faecal Bulking; 8 Ingredient Options and Gut Level Effects in Healthier Food Formulation; References; Reformulation as a Strategy for Developing Healthier Food Products: Challenges and Recent Developments
An Industry Perspective - Digital[edited by] Dimitri T. Azar ; associate editors, Damien Gatinel, Ramon C. Ghanem, Suphi Taneri.Contents:
Terminology, classification, and history of refractive surgery
Corneal wound healing following keratorefractive surgery
Physiologic optics for refractive surgery : an overview
Corneal topography
Wavefront analysis
Optical coherence tomography in refractive surgery
Excimer lasers
Laser and mechanical microkeratomes
Crosslinking instrumentation
Ocular diseases of importance to the refractive surgeon
Patient evaluation for refractive surgery
Preoperative evaluation of keratoconus and ectasia
LASIK, Q-based, and wavefront-guided LASIK for myopia, hyperopia, and astigmatism
LASIK and TopoLink for irregular astigmatism
LASIK complications and their management
Small-incision lenticule extraction (SMILE)
Small-incision lenticule extraction (SMILE) complications and their management
Photorefractive keratectomy
Lasek and epi-LASIK
Phototherapeutic keratectomy (PTK) and intralamellar PTK
Principles of corneal cross-linking
Epithelium off and transepithelial cross-linking : techniques and outcomes
Orthokeratology
Radial and astigmatic keratotomy
Conductive keratoplasty and laser thermokeratoplasty
The intrastromal corneal ring segments
Intraocular lens calculations after keratorefractive surgery
Phakic intraocular lens power calculations
Refractive lens exchange
Iris-fixated phakic intraocular lenses
Posterior chamber phakic intraocular lens
Complications of phakic intraocular lenses
Phakic intraocular lens explantation (PIOL) : causes and surgical techniques of PIOL exchange and bilensectomy
Physiology of accommodation and presbyopia
Monovision
Scleral surgery for presbyopia
Multifocal corneal surgery for presbyopia
Corneal implants and inlays
Multifocal intraocular lenses
Refractive surgical procedures to restore accommodation
Smart intraocular lenses, accommodating and pseudoaccommodating intraocular lenses for presbyopia
Postkeratoplasty astigmatism : etiology, management, and femtosecond laser applications.Digital Access ClinicalKey 2020 - DigitalGeorgia Malamut, Nadine Cerf-Bensussan, editors.Summary: This book is about recurring celiac disease its diagnosis and management. It starts by discussing the pathogenesis of refractory celiac disease and the role of viruses, microbiota and genetics in this disease. It also covers the epidemiological aspects. Refractory Celiac Disease is a unique resource on the topic written by a team of international experts in the topic and will be of great use to gastroenterologists and researchers in the field.
Contents:
1. Introduction
2. Pathogenesis of refractory celiac disease (I): role of virus and microbiota
3. Pathogenesis of refractory celiac disease (II): from refractory celiac disease to overt lymphoma
4. Pathogenesis of refractory celiac disease (III): genetic basis.-5. From unresponsive celiac disease to refractory celiac disease
6. Epidemiology of refractory celiac disease
7. Diagnosis of refractory celiac disease: Isolation-flow phenotyping and clonality
8. Diagnosis of refractory celiac disease: pathology
9. The other causes of severe enteropathy with villous atrophy non responsive to a gluten free diet
10. Treatment of Refractory Celiac disease. - DigitalAniyizhai Annamalai, editor.Summary: "Physicians receive very little training in refugee health. Refugee Health Care is a practical guide providing concise information for busy practitioners. This concise textbook reviews common conditions seen in refugees and some of the recommendations in the book apply to all immigrants. It will be a valuable resource for primary care physicians, psychiatrists, pediatricians, women's health providers and any health care practitioner who treats refugees."--Publisher's website.
Contents:
1. Introduction to refugees
2. Culturally appropriate care
3. Overview of domestic screening
4. Immunizations and refugees
5. Tuberculosis
6. Intestinal parasites
7. Viral hepatitis
8. Malaria
9. HIV and other sexually transmitted infections: testing and treatment considerations for refugees
10. Chronic disease management in refugees
11. Risk factors and prevalence of mental illness in refugees
12. Mental health screening
13. Treatment of mental illness
14. Torture and refugees
15. Refugee women's health
16. Health issues in refugee children
17. Medical evaluation of asylum seekers
Index.Digital Access Springer 2014 - Digitaledited by Aniyizhai Annamalai.Summary: Refugee health is growing as an academic medical discipline. More and more health care providers are coming together to exchange research information, educational curricula and social policies related to refugee health. The number of practitioners attending the annual North American Refugee Healthcare Conference has doubled since 2014. Refugees arrive in the United States from different parts of the world. Refugees undergo a medical screening soon after arrival, as recommended by the U.S. Department of State, and it is usually primary care practitioners who usually evaluate these patients at this first visit. Psychiatrists and other specialists may also evaluate them soon after arrival.Though physicians receive a variable amount of training in cross-cultural medicine, virtually none is in the area of refugee evaluations. There are several major ways that the field has changed. U.S. refugee policies and refugee admission numbers have changed dramatically in the past four years as has the epidemiology of medical conditions because the demographics of refugees have changed. The CDC guidelines for domestic screening have also been modified significantly as some of the screening tests are no longer recommended. Protocols have also been updated for presumptive treatment received by refugees before departure to the United States of other countries. A new chapter on end of life care for refugees has been added to the book. Now fully revised and expanded, this second edition reflects the many changes that have occurred in the field of refugee health since 2014. Refugee Health Care remains the definitive resource for primary care physicians and mental health practitioners who see and evaluate refugees. It is also relevant for medical, nursing and public health students involved with refugee health as well as resettlement agency workers and public health officials overseeing refugee care.
Contents:
Chapter 01 Introduction to Refugees
Chapter 2: Culturally Appropriate Care
Chapter 3 Domestic Health Assessment
Chapter 4 Immunizations
Chapter 5 Tuberculosis
Chapter 6 Parasitic Infections
Chapter 7 Viral Hepatitis
Chapter 8 Malaria
Chapter 9 HIV and Other Sexually Transmitted Infections
Chapter 10 Chronic Disease Management
Chapter 11 Chronic Pain
Chapter 12 Palliative and End-of-Life Care
Chapter 13 Risk Factors and Prevalence of Mental Illness
Chapter 14 Mental Health SCREENING
Chapter 15 Treatment of Mental Illness
Chapter 16 Torture and Violence
Chapter 17 Women's Health
Chapter 18 Pediatric Primary Care
Chapter 19 Medical Evaluation of Asylum Seekers. - DigitalSepanta Hosseinpour, Laurence J. Walsh, Keyvan Moharamzadeh, editors.Summary: This book provides evidence-based information in the field of regenerative dentistry discussing the most recent advances, current clinical applications, limitations and future directions. The coverage encompasses the regeneration of alveolar bone, the dentine-pulp complex, enamel, the periodontium and other tissues associated with the oral cavity. A full description is provided of regenerative approaches in dentistry including regenerative endodontics and tooth repair, regenerative periodontics, regenerative assisted orthodontics, regenerative approaches in oral medicine, and dental tissue derived stem cells and their potential applications. The book is written by an international team of leading experts. It will be beneficial for students, practitioners and researchers in the fields of endodontics, periodontics and implantology.
Contents:
The paradigm of regenerative dentistry and its future perspectives
Dental tissues originated stem cells for tissue regeneration
Dentin pulp complex regeneration
Clinical approach to regenerative endodontics
Tooth bioengineering and whole tooth regeneration
Regenerative approaches in periodontics
Regeneration for implant dentistry
Regenerative approaches in orthodontic and orthopaedic treatment
Regenerative approaches in oral and maxillofacial surgery
Regenerative approaches in oral medicine. - DigitalSuad Trebinjac, Manoj Kumar Nair.Summary: This book sheds new light on the complex area of regenerative injections used in sports injuries and musculoskeletal conditions, pursuing an evidenced-based approach. Largely ignoring orthopedic surgery, which would involve arthroscopic procedures and scaffolding as they are practiced mainly by orthopedic surgeons, the book instead focuses on injection-based treatments that are particularly useful in sports medicine and for musculoskeletal pain conditions. Including evidence from systematic reviews, meta-analyses, and randomized controlled trials, the book provides a comprehensive overview of regenerative injections such as dextrose, platelet-rich plasma and stem cell therapy, along with their history and scientific basis. It also includes detailed information on the preparation methods, steps of the procedure, and clinical conditions most likely to benefit from it. Given its scope, the book offers a valuable tool for all medical practitioners whose work involves painful musculoskeletal conditions, e.g. sports medicine physicians, orthopedists and interventional physiatrists, as well as general practitioners.
Contents:
Intro
Foreword
Contents
About the Authors
1: Introduction
1.1 Definition of Regenerative Medicine
1.2 Different Types of Regenerative Treatments
1.3 Importance of Regenerative Medicine in Sport
References
2: Injury Mechanisms in Sports
2.1 Shoulder
2.2 Elbow
2.3 Wrist and Hand
2.4 Hip and Groin
2.5 Knee
2.6 Ankle and Foot
References
3: Current Practices in Sports Injury Rehabilitation
3.1 Goal-Oriented Rehabilitation Pathway
References
4: Prolotherapy
4.1 Definition of Prolotherapy
4.2 History of Prolotherapy 4.3 Prolotherapy: Mechanism of Action
4.4 Indications and Contraindications for Dextrose Prolotherapy
References
5: Dextrose Prolotherapy: Preparation Methods and Protocols of Treatment
5.1 Animals Study on Dextrose Prolotherapy
References
6: Clinical Applications of Dextrose Prolotherapy in Sports
6.1 Shoulder
6.2 Elbow
6.3 Wrist and Hand
6.4 Hip and Groin
6.5 Knee
6.6 Ankle and Foot
References
7: Platelet Rich Plasma
7.1 Definition
7.2 History
7.3 Mechanism of Action
7.4 Assessment of Platelet Function
References 8: Platelet Rich Plasma: Preparation Methods
8.1 Activation of Platelets
8.2 Classifications of PRP Preparations
8.3 Different Types of Platelet Preparations
8.3.1 Platelet Gel
8.3.2 Comparison of Various PRP and Platelet Lysate
References
9: Clinical Applications of Platelet Rich Plasma in Sports
9.1 PRP in Muscle Injuries
9.2 PRP in Tendon and Ligament Pathologies
9.3 Anterior Cruciate Ligament Pathology
9.4 Rotator Cuff Tendinopathy
9.5 Patellar Tendinopathy
9.6 Plantar Fasciitis
9.7 Lateral Epicondylitis
9.8 Ankle Ligaments 9.9 Achilles Tendinopathy
9.10 Greater Trochanteric Pain Syndrome (GTPS)
9.11 Knee Osteoarthritis
9.12 Variables Affecting the Efficacy of PRP Preparations
References
10: Settings for PRP Injections
10.1 Equipment
10.2 PRP Centrifuge
10.3 PRP Kit (Fig. 10.2)
10.4 Miscellaneous
10.5 Steps in Collection
References
11: Stem Cells
11.1 Definition
11.2 History of Stem Cells
11.3 The Main Features of Stem Cells
11.4 Sources of Stem Cells
11.5 Mechanism of Action
References
12: Stem Cells: Preparation Methods 12.1 Collection of Stem Cells
12.2 BMAC Harvesting and Processing Technique
12.3 Harvesting and Processing of Adipose Tissue
References
13: Clinical Applications of Stem Cells in Sports
13.1 Mesenchymal Stem Cell Treatment in Ligament and Tendon
13.1.1 Basic Principle
13.2 Mesenchymal Stem Cells in Patellar Tendinopathy
13.3 Mesenchymal Stem Cells in Osteoarthritis
References
14: Rehabilitation After Regenerative Injection procedures
14.1 Rehabilitation After Platelet Rich Plasma Injection for Patellar Tendinopathy
14.2 Return to Play DecisionsDigital Access Springer 2020 - DigitalCorey W. Hunter, Timothy T. Davis, Michael J. DePalma, editors.Summary: This book explores the rapidly growing subspecialty of regenerative medicine in pain management. It provides concise guidelines and instruction for healthcare providers interested in implementing this novel therapy. The book contains three sections and begins with a thorough introduction to the field. Additionally, section one examines various therapies such as stem cell collection, allograft therapies, and bone marrow aspirations. Section two then delves into the medical diagnosis and procedural guidance methods, including ultrasound imaging, discography, local anesthetics, and anticoagulation medications. Following this, section three concludes the book with numerous discussions on standardized treatment paradigms. A unique, first-of-its-kind book, Regenerative Medicine seeks to inspire medical practitioners to integrate this subspecialty into pain management therapies and treatments.
Contents:
Part I. Basics of Regenerative Medicine
Chapter 1. Introduction to Regenerative Medicine
Chapter 2. Prolotherapy
Chapter 3. Blood Products
Chapter 4. Bone Marrow Aspirate and the Use of Autologous Cells and Cellular Products in Regenerative Medicine
Chapter 5. Adipose-Derived Stromal Stem Cells
Chapter 6. Intra-annular Fibrin DiscseelProcedure to Diagnose and Treat Disc Pathology.-Chapter 7. Allograft Therapies in Regenerative Medicine
Chapter 8. Adult Mesenchymal Stem Cell Collection and Banking
Chapter 9. Exosomes
Chapter 10. Exosomes in Stroke and Trauma: Current Concepts for Clinicians.-Part II. Imaging, Guidance, and Planning
Chapter 11. Basics of Ultrasound
Chapter 12. Ultrasound Guided Interventions: In-Plane and Out-of-Plane
Chapter 13. Probe Selection
Chapter 14. Diagnostic Musculoskeletal Ultrasound: Recognizing Pathology
Chapter 15. Fluoroscopic Safety
Chapter 16. Pre-procedural Imaging
Chapter 17. Discography
Chapter 18. Procedure Planning for Ultrasound Guided Injections
Chapter 19. Effects of Local Anesthetics and Contrast Agents on Regenerative Medicine Procedures
Chapter 20. Medicolegal Aspects of Regenerative Medicine.-Chapter 21. Anti-Platelet and Anticoagulation Medications
Chapter 22. Patient Factors Affecting Regenerative Medicine Outcomes.-Part III. Treatment Paradigms Orthobiologics and Additional Utilities
Chapter 23. Tendinopathy
Chapter 24. Bone Marrow Derived Stem Cells and their Application in Pain Medicine
Chapter 25. The Use of Platelet-Rich Plasma and Mesenchymal Stem Cells in the Lumbar and Lumbosacral Spine: Concepts, Literature Review and Recommendations
Chapter 26. Adipose Derived Regenerative Cellular Therapy of Chronic Wounds
Chapter 27. Aesthetic Surgery Applications for Adipose-Derived Stem Cells. - DigitalNiranjan Bhattacharya, Phillip George Stubblefield, editors.Summary: This book represents a major contribution to the emerging science of regenerative medicine using non-fetal sources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have brought together some of the most pre-eminent scientists working on regenerative medicine to share information on currently ongoing work in this area alongside unpublished observations that will help to shape the contours of future therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem Cells discusses the potential clinical and therapeutic applications using non-fetal stem cells as well as providing instruction on the collection, isolation and characterization of stem cells from various non-fetal sources, such as menstrual blood, adipose tissue, breast milk and uprooted decidual teeth. This book will be an invaluable resource for both active researchers and those entering the field. The Editors truly hope that the text will act as a stimulant to professionals and clinical scientists, who may be inspired to further the work of the pioneering scientists who have contributed to this volume.
Contents:
Multipotent Mesenchymal Stromal Cell-Based Therapies: Regeneration Versus Repair
The Role Of Microenvironment Stromal Cells In Regenerative Medicine
Identity Of Human Endometrial Tissue: Potent Source Of Stem Cells
Endometrial Regenerative Cells and Exosomes Thereof for Treatment of Radiation Exposure
Endometrial stem cells as potential cures for human diseases
Menstrual Blood Transplantation Therapy for Stroke and other Neurological Disorders
Characteristics and therapeutic potential of menstrual blood-derived stem cells
Use of Animal Fats in Traditional Chinese Medicine
Adipose-derived stem cells for therapeutic applications
Subcutaneous adipose tissue derived stem cells: advancement and applications in regenerative medicine
Expanded adipose tissue-derived stem cells for articular cartilage injury treatment: a safety and efficacy evaluation
Redundant human omentum fat: a leap towards regenerative medicine
Human Adipose-derived Stem Cells (ASC):Their Efficacy in Clinical Applications
Potentialities of adipose-derived mesenchymal stem cells collected from liposuction for use in cellular therapy
Stem cells from dental tissue for regenerative dentistry and medicine
Dental Stem Cells Risk and Responsibilities
Stem Cells & Deciduous Teeth Responsibilities
Breastmilk Stem Cells: Recent Advances and Future Prospects
Existence of mesenchymal-like somatic stem cells in the porcine uterus
Human menstrual blood-derived stem cell transplantation for acute hind limb ischemia treatment in mouse models
Of Baul behaviour, Stem Cell Primitive application?
Application of Umbilical Cord and Cord Blood as alternative modes for Liver Therapy
Crushed finger and its repair after placing it inside abdominal fatty tunnel for 6 weeks: A preliminary experience
Understanding the science behind regeneration for its implications in medicine for future
Uterine synechia: A preliminary communication on an attempted treatment of the condition with intrauterine instillation of autologous bone marrow monoclear cells
Freshly collected amniotic fluid and amniotic membrane as dressing material for Leprosy patients with gangrene: A preliminary report on an experience with 6 cases
Use of fetal skin and amniotic fluid dressing for non-healing burn patients in pediatric age group: A study of 5 cases
Concern for pharmacogenomics and autologous cell therapy: Can this be a direction towards medicine for the future?
Chronic wound of the skin and amniotic membrane based treatment potential
Ethics and Moral principles in the practice of medicine. - DigitalDominik Duscher, Melvin A. Shiffman, editors.Summary: This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields."--Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine.
Contents:
Elements of regenerative medicine
Research concepts
Emerging technologies
Translational aspects
Regenerative plastic surgery.Digital Access Springer 2019 - DigitalDominik Duscher, Melvin A. Shiffman, editors.Summary: This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The books third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction."--Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine.
Contents:
Skin and soft tissue regeneration
Bone regeneration
Cartilage regeneration
Muscle and tendon regeneration
Nerve regeneration.Digital Access Springer 2019 - Digital[edited by] Giuseppe Orlando, Jan Lerut, Shay Soker, Robert J. Stratta.Contents:
Principles of regenerative medicine and cell,tissue and organ bioengineering
Kidney
Liver
Heart
Small bowel
Endocrine pancreas and islets of langerhans
Lung
Composite tissues allotranplantation
Immunosuppression-free transplantation in the regenerative medicine era.Digital Access ScienceDirect 2014 - DigitalLinda F. Hogle, editor.Summary: Regenerative medicine is at a pivotal point. Innovations in the science and the rapid growth of translational medicine are transforming the field just as institutional arrangements are changing, making this an exciting yet unsettled time. Recent court cases and policy initiatives are creating crosscurrents that keep older issues from being settled while introducing new dilemmas. Current research propels collaborations across disciplines and sectors, raising the question of how tensions between the protection of intellectual property and the movement toward "open science" can be negotiated. Other important social, ethical and legal questions arise in the gray areas created by new scientific techniques and pragmatic areas involved in scale-up and testing in humans. The times call for governance that is adaptive to meet the needs of science yet able to maintain public trust. The contributors address these and other vital questions through chapters focusing on topics such as data sharing; patenting of human biological material; and managing collaborations across academic, industry and government sectors as well as across national boundaries. Key research ethics issues are also included such as obtaining consent from biospecimen donors; accessing biorepository data, and considerations in designing preclinical and clinical trial protocols for first-in-human research, including upcoming policy changes. Rather than retracing well-trodden topics, the book points to nascent areas that need to be addressed. Whether working in academia, industry, or government, regenerative medicine scientists and managers need to know how to navigate current and upcoming issues of governance facing the field. Regenerative Medicine Ethics: Governing Research and Knowledge. Practices will be a valuable resource for scientists, policy-makers and students as they plan and execute responsible research.Digital Access Springer 2014
- DigitalGrant Cooper, Joseph Herrera, Jason Kirkbride, Zachary Perlman, editors.Summary: Regenerative medicine (RM) is a rapidly expanding topic within orthopedic and spine surgery, sports medicine and rehabilitation medicine. In the last ten years, regenerative medicine has emerged from the fringes as a complement and challenge to evidence-based medicine. Both clinicians and patients alike are eager to be able to offer and receive treatments that don't just surgically replace or clean old joints or inject away inflammation or work as a stop-gap measure. Regenerative medicine encompasses everything from the use of stem cells and platelet-rich plasma (PRP) to prolotherapy, viscosupplementation and beyond. This book will provide healthcare practitioners dealing with spine and joint pain with the most current, up-to-date evidence-based information about which treatments work, which treatments don't, and which are on the horizon as potential game changers. Chapters are arranged in a consistent format and cover the spine, shoulder, elbow, hand and wrist, hip, knee, and foot and ankle, providing a thorough, top-to-bottom approach. A concluding chapter discusses current and future directions and applications of RM over the next decade or two. Timely and forward-thinking, Regenerative Medicine for Spine and Joint Pain will be a concise and practical resource for orthopedists, spine surgeons, sports medicine specialists, physical therapists and rehabilitation specialists, and primary care providers looking to expand their practice.
Contents:
Intro
Contents
Contributors
Chapter 1: Introduction to Regenerative Medicine
Regenerative Medicine Intro Combined
References
Chapter 2: Basic Science Concepts in Musculoskeletal Regenerative Medicine
Introduction
Musculoskeletal Development
Early Musculoskeletal Embryogenesis
Bone Embryogenesis
Synovial Joint Development
Spine Joint Development
Tendon and Ligament Development
Musculoskeletal Tissue Homeostasis and Response to Injury
Osteoarthritis of Articular Cartilage
Intervertebral Disc Degeneration
Tendon and Ligament Degeneration Conclusion
References
Chapter 3: Viscosupplementation
Introduction
History
Biology
Indications
Procedure
Efficacy
Treatment Algorithms
Safety
Comparison to Alternative Treatments
Glucosamine and Chondroitin
Market
References
Chapter 4: Stem Cells
Introduction
History
Bone Marrow-Derived Stem Cells
Adipose-Derived Stem Cells
Amniotic Tissue-Derived Products
Adverse Events Associated with Stem Cell Therapy
Conclusion
References
Chapter 5: Platelet-Rich Plasma
Introduction
Basic Science of PRP and Mechanism of Action Creation and Classification of PRP
Clinical Applications of PRP
Tendinopathy
Osteoarthritis
Ligament and Meniscus Injuries
Muscle Injuries
Spine Disorders
Advantages of PRP
Disadvantages of PRP
Regulation of PRP
Future Directions
References
Chapter 6: Prolotherapy
Introduction
Mechanism of Action
Effects of Prolotherapy on Ligaments and Tendons In Vitro and in Animal Studies
Osteoarthritis Clinical Studies
Prolotherapy Effects on Small Joints
Prolotherapy Effects on Knee Osteoarthritis Intra-articular Prolotherapy Treatment Versus Corticosteroid and Platelet-Rich Plasma Treatments
Intra-articular Versus Extra-articular Injections for Joint Pain
Sacroiliac Joint and Axial Spine Prolotherapy Treatments
Tendinopathy Clinical Studies
Lateral Epicondylitis
Achilles Tendinopathy
Rotator Cuff Tendinopathy
Side Effects and Adverse Events
References
Chapter 7: Regenerative Medicine for the Spine
Introduction
Epidemiology
Anatomy
Overview of Back Pain Pathology and Treatment
Pain Generators of the Spine
Intervertebral Disc Pain Radiculopathy
Zygapophyseal Joint (Facet) Arthropathy
Sacroiliac Joint Dysfunction
Back Musculature Atrophy
Back Ligament Dysfunction
Overall Levels of Evidence
Limitations of Current Studies and Future Implications
Regulation Concerns
Future Directions
Conclusion
References
Chapter 8: Regenerative Medicine for the Shoulder
Tendinopathy in the Shoulder: The Rotator Cuff and Proximal Biceps Tendon
Rotator Cuff Tendinopathy
Rotator Cuff Tears
Biceps Tendinopathy
Tendinopathy in the Shoulder: Regenerative Medicine Applications - DigitalJuichi Ito, editor.Summary: The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
Contents:
Part I. Targets of Regenerative Medicine for the Inner Ear
1. Anatomy of the Inner Ear
2. Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear
3. Hair cell
4. Stereocilia
5. Cochlear Lateral Wall
6. Spiral Ganglion Cell and Auditory Neuron
7. Synaptic Contacts between Hair Cells and Primary Neurons
8. Otolith
9. Tectorial membrane
Part II. Development of the Inner Ear
10. Development and regeneration
11. Otic Induction
12. Cochlear Development
13. Vestibular Development
Part III. Cochlear Implants
14. Cochlear Implant: Past, Present and Future
15. Recent Progress in Cochlear Implant
16. Regenerative medicine in cochlear implantation
17. Artificial cochlear epithelium
18. Auditory Brainstem Implant
Part IV. Hair Cell Regeneration
19. Hair Cell Regeneration in the Avian
20. Self Repair
21. Transdifferentiation
22. Dedifferentiation-mediated Regeneration
23. Gene Therapy
24. Cell Therapy
Part V. Spiral Ganglion Neuron Regeneration
25. Clinical Background
26. SGN development
27. Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons
28. Cell therapy
29. Afferent dendrite and axon
Part VI. Stem Cells
30. Inner ear stem cells
31. Pluripotent Stem Cells
32. Somatic Stem Cells
Part VII. Future Perspective
33. Regenerative Medicine for the Inner Ear
Summary. - DigitalXiaobing Fu, editor.Summary: This book includes major issues in wound tissue repair and regeneration in 14 chapters. The topics start from cytological basis, molecular and genetic basis, skin development, to the tissue repair, visceral injury and tissue engineering. In the second part, it introduces Chinese researchers contribution in wound repair and regeneration. Specially, it has 3 chapters discussing new technologies in tissue repair and regeneration, and 1 chapter in Traditional Chinese Medicine.
- DigitalJuichi Ito, editor.Contents:
Preface
Part 1: Current siguation of the regenerative medicine
Chapter 1: Current siguation of the regenerative medicine
Part 2: Development and regeneration of the ear.- Chapter 2: The innner ear
Chapter 3: Regeneration of the Soft Tissue Defects of the External Auditory Meatus
Chapter 4: Regeneration of the Tympanic Membrane
Chapter 5: An approach in regenerative medicine for the treatment of intractable otitis media
Chapter 6: Peripheral Nerve Regeneration by Tissue Engineering for Prevention of Misdirection
Part 3: Development and regeneration of the nose and the paranasal sinuses
Chapter 7: Development and regeneration of the nose and the paranasal sinuses
Part 4: Development and regeneration of the oral cavity and the pharynx
Chapter 8: Development and regeneration of the oral cavity and the pharynx
Part 5: Development and regeneration of the larynx
Chapter 9: Laryngeal Development
Chapter 10: Laryngeal framework regeneration
Chapter 11: Vocal folds Development
Chapter 12: Regeneration of the vocal fold
Part 6: Development and regeneration of the head & neck
Chapter 13: Cranial bone regeneration
Chapter 14: Salivary gland development and regeneration
Chapter 15: Regeneration of the Trachea
Chapter16: Future perspective.Digital Access Springer 2015 - DigitalHernán Pinto, Joan Fontdevila, editors.Summary: This book presents the state-of-art in regenerative procedures currently applied by aesthetic physicians, plastic surgeons and dermatologists. It is divided into two parts, the first of which provides a detailed introduction to aesthetic medicine and the aging process. The second part, in turn, addresses the current status of techniques and technologies with regard to autologous grafts, covering fat transfer, blood grafts, skin grafts and stem cells. The book examines the surgical applications of these grafts, as well as potential side effects and limitations. Therapy combinations and outcomes round out the coverage. Aesthetic physicians, plastic surgeons and dermatologists interested in performing regenerative procedures for aesthetic purposes will find this book to be a valuable guide. -- Provided by publisher.
Contents:
Part 1. Approaches: Introduction
Chapter 1. Regenerative medicine and its countless possibilities
Chapter 2. Trends in Aesthetic Medicine: a new way to approach patients needs
Chapter 3. The Molecular Physiology of Ageing – New targets for regenerative medicine
Part 2. Approaches: The process of aging
Chapter 4
Beauty and Aging
Chapter 5. Reducing the Damage: Metabolism behaviour Aesthetic Medicine
Chapter 6. Procurement of Fat Grafts
Part 3. Approaches: Strategies to reduce the clinical impact of aging
Chapter 7. Fat Graft processing and Enrichment Strategies
Chapter 8. Nano, Micro and Macro Fat grafts and SNIF: special grafts for outcome enhancement
Chapter 9. Fat Graft application
Part 4. Regenerative Medicine Procedures for Aesthetic Physicians:. State of the art: Fat transfer, lipo-filling
Chapter 10. Lipofilling in reconstructive surgery: Indications, outcomes and complications
Chapter 11. Lipofilling in aesthetic surgery: indications outcomes and complications
Chapter 12. Enriched plasmas. Techniques, processing, and clinical interaction
Chapter 13. Platelet-Rich Plasma applications. Was it gold what shone
Chapter 14. Autologous conditioned serum as an antiaging tool
Part 5. Regenerative Medicine Procedures for Aesthetic Physicians: Skin Grafts
Chapter 15. Skin cell cultures and skin engineering
Chapter 16. Skin grafts
Chapter 17
Skin Micrograft Injection/application
Chapter 18
Techniques and processing methods to isolate stem cells and stromal vascular fraction cells
Part 6. Regenerative Medicine Procedures for Aesthetic Physicians: Stem cells
Chapter 19. Regenerative Medicine Procedures for Aesthetic Physicians
Chapter 20. Stem cells in Aesthetic Medicine
Part 7. Regulation and conclusions
Chapter 21. Regulation
Chapter 22. General Conclusions: The Current Status of the Regenerative Medicine. - DigitalJames C. Melville, Jonathan W. Shum, Simon Young, Mark E. Wong, editors.Summary: This book is designed as a comprehensive and up-to-date instructional guide to the strategies employed for regeneration of the maxillomandibular region, with emphasis on allogeneic and tissue engineering principles. Readers will find information on indications and contraindications for procedures, pertinent anatomy, surgical techniques, postoperative management, and management of complications. Current surgical techniques utilizing biotechnology for regeneration and reconstruction are described in depth, with explanation of their benefits in minimizing patient morbidity. In addition, state of the art free vascular transfer for maxillary and mandibular reconstruction is extensively discussed, with a particular focus on indications and step-by-step technique. The authors are well-known experts in their field who are keen to share their extensive experience and preferred approaches. The book is intended for all oral and maxillofacial surgeons, head and neck surgeons, and plastic and reconstruction surgeons who wish to increase their knowledge on the latest modalities of maxillary and mandibular reconstruction.
- DigitalJulia Lynch.Summary: "A spectacular thirty-meter high viaduct spans the Ouseburn river as it makes its way through Newcastle-upon-Tyne, in the northeast corner of England. Modern, bright-yellow and black tram cars ply the viaduct, bringing passengers from working-class Byker to more affluent South Gosforth station in a journey that takes roughly ten minutes. But while the Byker viaduct allows riders to traverse the physical chasm carved out by the Ouseburn with ease, the social differences that separate residents of Byker from their better-off neighbors are much harder to bridge. Twice as many children in Byker (two in five) live in poverty as in Gosforth. And while a fifty-five-year-old man from Gosforth can expect to live another seventeen years in good health, the average fifty-five-year-old in Byker has only another nine years of healthy life expectancy ahead of him (Bambra 2016, 92)"-- Provided by publisher.
Contents:
Explaining resilient inequalities in health and wealth
Theorizing regimes of inequality : welfare, neoliberalism, and the reframing of a social problem
Health inequalities : the emergence of an international consensus policy frame
New Labour, the redistributive taboo, and reframing inequality in England after the Black Report
Inequality, territory, austerity : health equity in France since the U-turn
From risk factors to social determinants : how the changing Social Democratic welfare regime in Finland reframed health inequality
In and out of the Overton window : how talking about health inequality made the problem harder to solve
Regimes of inequality
Appendix: Content analysis of government and commissioned health inequality reports.Digital Access Cambridge 2020 - Printby Charles V. Morrill ...Contents:
[v. 1] The upper extremity
[v. 2] The neck and head
[v. 3] The abdomen and pelvis
[v. 4] The thorax and back. - PrintTaylor, John Alexander.Contents:
pt. 1. Head and neck
pt. 2. Thoracic limb
pt. 3. Pelvic limb
pt. 4. Thorax and abdomen. - DigitalDanilo Jankovic, Philip Peng, editors.Summary: This comprehensive atlas, which includes a wealth of illustrations and anatomic pictures created by the editors, covers a broad range of both regional anesthesia and pain intervention techniques, including neuromodulation. The book is unique in that it covers ultrasound and fluoroscopic-guided techniques, as well as traditional landmark-guided techniques. The authors and editors are internationally renowned experts, and share extensive theoretic and practical insights into regional anesthesia, pain therapy and anatomic sciences for everyday practice. The book addresses the application of ultrasound and fluoroscopic guidance for pain interventions and provides detailed coverage of ultrasound-guided and landmark-guided regional anesthesia. The book represents a detailed guide to the application of regional anesthesia and pain medicine; furthermore, examples of medico-legal documentation are also included in this edition. The 5th edition of Regional Nerve Blocks in Anesthesia and Pain Medicine is practically oriented and provides essential guidelines for the clinical application of regional anesthesia. It is intended for anesthesiologists and all professionals engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.
Contents:
Part I. General Consideration
Regional nerve block in anesthesia and pain therapy-general consideration
Basic of ultrasound imaging
Use of nerve stimulation in regional anesthesia
Complication of regional anesthesia
Local anesthetic systemic toxicity
Part II. Nerve Block for Regional Anesthesia and Pain Therapy in Head and Neck Region
Regional anesthesia in ophthalmology
Regional anesthesia for airway.-Nerve block for trigeminal nerve (superficial)
Nerve block for trigeminal nerve (deep)
Gasserian ganglion ablation and sphenopalatine ganglion intervention
Occipital nerve
Cervical sympathetic chain and superior cervical ganglion
Cervical plexus block
Cervical interlaminar epidural injection
Cervical facet nerve block and denervation
Cervical nerve root injection
Cervical dorsal root ganglion pulsed radiofrequency treatment
Part III. Nerve Block for Regional Anesthesia and Pain Therapy for Shoulder
Suprascapular nerve
Axillary nerve
Nerve block for pain therapy in shoulder
Rotator muscles and subscapular nerve injection
Calcific tendinitis intervention
Shoulder joint denervation
Part IV. Nerve Block for Regional Anesthesia and Pain Therapy for Upper Limb
Brachial plexus-Anatomy
Brachial plexus above the clavicle
Brachial plexus below the clavicle
Brachial plexus block-landmark guided technique
Intravenous regional anesthesia IVRA
Peripheral nerve block around elbow or forearm
Pain procedures around elbow
Pain procedures around wrist
Part V. Nerve Block for Regional Anesthesia and Pain Therapy in Chest, Abdomen and Pelvis
Thoracic paravertebral block
Pectoralis nerve and serratus plane block
Transverse abdominal plane block
Quadratus lumborum block
Intercostal nerve block
Ilioinguinal and genitofemoral nerve block
Piriformis and obturator internus injection
Pudendal nerve
Paracervical block
Part VI. Nerve Block for Regional Anesthesia and Pain Therapy in Neuraxial Region
Neuraxial anatomy and sonoanatomy
Neuraxial anesthesia and analgesia for surgery
Neuraxial anesthesia and analgesia for obstetric practice
Thoracic facet block
Celiac plexus block
Lumbar sympathetic block
Lumbar facet nerve and joint block
Lumbar facet denervation
Superior hypogastric plexus and ganglion impar block
Sacroiliac joint injection
Sacral lateral branch block and radiofrequency ablation
Sacral nerve root
Caudal epidural
Lumbosacral epiduroscopy
Percutaneous epidural neuroplasty
Part VII. Nerve Block for Regional Anesthesia and Pain Therapy for Lower Limb
Lumbar plexus block-anterior approach (femoral nerve, 3-in-1, fascia iliaca block)
Posterior approach to peripheral nerve block in the lumbar region
Lateral femoral cutaneous nerve
Obturator nerve
Sciatic nerve-proximal
Sciatic nerve-distal
Adductor canal block
iPACK block
Hip joint and trochanteric bursa injection
Hip joint pericapsular nerve group block and denervation
Knee joint injection
Knee joint denervation
Ankle nerve block
Ankle joint injection
Metatarsophalangeal joint and Mortons neuroma injection
Landmark guided technique for regional anesthesia of lower limb
Part VIII. Neuromodulation Therapy
Peripheral nerve stimulation
Spinal cord stimulation
Intrathecal drug delivery system
Part IX. Regional Anesthesia for Children
Regional anesthesia for upper limb in children
Regional anesthesia for lower limb in children
Truncal and neuraxial blockade in children. . - DigitalDanilo Jankovic, Philip Peng.Contents:
General Considerations
Head and Neck Region
Cervical Region
Shoulder
Upper extremity
Elbow and Wrist
Thoracic Region
Lumbosacral spine
Abdominal and Pelvic region
Lower extremity block
Lower extremity musculoskeletal injection
Regional block for children. - Digital/PrintDigital Access Google Books 1964-
- Digitalby Ton J. Cleophas, Aeilko H. Zwinderman.Summary: This edition is a pretty complete textbook and tutorial for medical and health care students, as well as a recollection/update bench, and help desk for professionals. Novel approaches already applied in published clinical research will be addressed: matrix analyses, alpha spending, gate keeping, kriging, interval censored regressions, causality regressions, canonical regressions, quasi-likelihood regressions, novel non-parametric regressions. Each chapter can be studied as a stand-alone, and covers one field in the fast growing world of regression analyses. The authors, as professors in statistics and machine learning at European universities, are worried, that their students find regression-analyses harder than any other methodology in statistics. This is serious, because almost all of the novel methodologies in current data mining and data analysis include elements of regression-analysis. It is the main incentive for writing this 28 chapter edition, consistent of - 28 major fields of regression analysis, - their condensed maths, - their applications in medical and health research as published so far, - step by step analyses for self-assessment, - conclusion and reference sections. Traditional regression analysis is adequate for epidemiology, but lacks the precision required for clinical investigations. However, in the past two decades modern regression methods have proven to be much more precise. And so it is time, that a book described regression analyses for clinicians. The current edition is the first to do so. It is written for a non-mathematical readership. Self-assessment data-files are provided through Springer' s "Extras Online."
Contents:
Preface
Continuous Outcome Regressions
Dichotomous Outcome Regressions
Confirmative Regressions
Dichotomous Regressions Other than Logistic and Cox
Polytomous Outcome Regressions
Time to Event Regressions other than Traditional Cox
Analysis of Variance (ANOVA)
Repeated Outcome Regressions
Methodologies for Better Fit of Categorical Predictors
Laplace Regressions, Multi- instead of Mono-Exponential Models
Regressions For Making Extrapolations
Standardized Regression Coefficients
Multivariate Analysis of Variance and Canonical Regression
More on Poisson Regressions
Regression Trend Testing
Optimal Scaling and Automatic Linear Regression
Spline Regressions
More on Nonlinear Regressions
Special Forms of Continuous Outcome Regressions
Regressions for Quantitative Diagnostic Testing
Regressions, a Panacee or at Least a Widespread Help for Data Analyses
Regression Trees
Regressions with Latent Variables
Partial Correlations
Functional Data Analysis I
Functional Data Analysis II
Index. - DigitalMario L. Rocci Jr., Stephen Lowes, editors.Summary: This book is intended to cover the fundamental and practical aspects of regulated bioanalysis. The editors are seeking leading scientists in the field to participate in the development of this book, which we envision as a "one of a kind" contribution to our field. The book is intended for students in the pharmaceutical sciences, chemistry, biology and related scientific disciplines interested in bioanalysis, as well as working scientists new to the field of regulated bioanalysis. It will also serve as a primer for those experienced in the field. The depth of the book will seek to give its audience a solid foundation of knowledge in regulated bioanalysis which can be leveraged further with "hands on" experience. Understanding that bioanalytical global regulations evolve, the book is not intended as a deep-dive into regulatory language nuances but rather to be an educational text on conducting defendable and auditable science to support modern bioanalysis. Following an introduction to the topic by the editors, the book then covers "non-scientific" aspects of the topic area including the regulations governing this work, logistical and operational aspects of running a regulated bioanalytical laboratory and appropriate laboratory documentation. Next a description of the typically encountered types of bioanalytical samples, analytes and their attributes is provided. This information then sets the stage for a detailed discussion of the analytical platforms and assay types used in the regulated bioanalysis of small and large molecules. Also provided is a discussion of the different analytical phases of the bioanalytical process (i.e. method development including various strategies, pre-study validation and sample analysis).
Contents:
Introduction
Understanding Bioanalysis Regulations
Logistical and Operational Practice in the Regulated Bioanalysis Laboratory
Regulated Bioanalysis: Documentation and Reports
Historical Aspects and Key Concepts Related to its Use
Fundamentals of LC-MS/MS for Regulated Bioanalysis
Liquid Chromatography-Mass Spectrometry Assays in the Regulated Bioanalytical Laboratory
Development and maintenance of critical reagents for ligand binding assays to support regulatory-compliant bioanalysis
Ligand Binding Assays in the Regulated Bioanalytical Laboratory. - Digitaledited by Avi Ashkenazi, Junying Yuan and James A. Wells.Contents:
Examining the molecular mechanism of Bcl-2 family proteins at membranes by fluorescence spectroscopy
Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry
The structural biology of BH3-only proteins
How to analyze mitochondrial morphology in healthy cells and apoptotic cells in Caenorhabditis elegans
Apoptosis initiation through the cell-extrinsic pathway
Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway
Caspase enzymology and activation mechanisms
Turning on caspases with genetics and small molecules
A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases
Measuring caspase activity in vivo
Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology
In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe
Global analysis of cullular proteolysis by selective enzymatic labelling of protein N-termini
Complementary methods for the indentification of substrates of proteolysis
Phospholipid scrambling on the plasma membrane
Studying apoptosis in the zebrafish.Digital Access ScienceDirect 2014 - Digitaledited by Sajal Chakraborti, Naranjan S. Dhalla.
- DigitalJie Xu.Summary: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Contents:
Introduction
Molecular and cellular functions of CTLA-4 pathway
Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond
Discovery of new immune checkpoints: family grows up
Mechanisms of resistance to checkpoint blockade therapy
Molecular events behind adverse effects
Rational discovery of response biomarkers
Spatiotemporal changes in checkpoint molecule expression
Functions of checkpoint molecules beyond immune evasion
Genetic alterations and checkpoint expression
Regulations on messenger RNA: wires and nodes
Folded or degraded in endoplasmic reticulum
Mono- and poly-ubiquitination: tags for fates
Lysosome as the black hole for checkpoint molecules
Phosphorylation: a fast switch for checkpoint signalling
Palmitoylation as a signal for delivery
Checkpoints under traffic control: from and to organelles
Exosome and secretion: action on?
Macromolecules and antibody-based drugs
Mechanisms inspired targeting peptides
Small molecular inhibitors
Therapeutic development of immune checkpoint blockers
Concluding remarks. - Digital/PrintXiaojing Ma, editor.Contents:
Regulation of IFN-[gamma] expression / John Fenimore, Howard A. Young
The interleukin-1 family / Amir S. Yazdi, Kamran Ghoreschi
Regulation of IL-4 expression in immunity and diseases / I-Cheng Ho, Shi-Chuen Miaw
Regulation of IL-6 in immunity and diseases / Toshio Tanaka, Masashi Narazaki, Kazuya Masuda, Tadamitsu Kishimoto
Regulation of interleukin-10 expression / Sascha Rutz, Wenjun Ouyang
Regulation of interleukin-12 production in antigen-presenting cells / Hua Zheng, Yi Ban, Fang Wei, Xiaojing Ma
Regulation of interleukin-17 production / Wenjuan Dong, Xiaojing Ma
Regulation of interleukin-23 expression in health and disease / Iain Welsby, Stanislas Goriely
Regulation and immune function of IL-27 / Qinghong Wang, Jianguo Liu
The immunobiology of interleukin-35 and its regulation and gene expression / Mei Song, Xiaojing Ma.Digital Access Springer 2016 - Digital/PrintDigital Access Google Books 1972-
- DigitalRodney D. Geisert, Fuller W. Bazer, editors.Summary: Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics, along with the ability to selectively knockout genes of interest, have greatly advanced our understanding of the maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides the basis for new research endeavors to address infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. This book brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. The reviews provide readers with the latest knowledge on the role of the endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved in the regulation of conceptus development. .
Contents:
Introduction -Rodney Geisert
History of Maternal Recognition of Pregnancy
Fuller W. Bazer
The Role of Steroids Hormone Receptors in the Establishment of Pregnancy in Rodents
Nyssa R. Adams and Francesco J. DeMayo
Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation
Pamela E. Constantinou, Micaela Morgado and Daniel D. Carson
Reflections on Rodent Implantation
Jeeyeon M. Cha and Sudhansu K. Dey
The Role of Progesterone in Maternal Recognition of Pregnancy in Domestic Ruminants
Pat Lonergan and Niamh Forde
Implantation and Establishment of Pregnancy in Ruminants
Thomas E. Spencer and Thomas R. Hansen
Implantation and Establishment of Pregnancy in the Pig
Rodney D. Geisert, Gregory A. Johnson and Robert C. Burghardt
Pregnancy Recognition and Implantation of the Conceptus in the Mare
Claudia Klein
Implantation and Establishment of Pregnancy in Human and Non-Human Primates
Ren-Wei Su and Asgerally T. Fazleabas
The Dog: Nonconformist, Not Only In Maternal Recognition Signaling
Mariusz P. Kowalewski, Aykut Gram, Ewa Kautz, Felix Graubner
Embryonic Diapause and Maternal Recognition of Pregnancy in Diapausing Mammals
Marilyn B. Renfree
Predicting Embryo Presence and Viability
Ky G. Pohler, Jonathon A. Green, Thomas W. Geary, R.F.G. Peres, M.H.C. Pereira, J.L.M. Vasconcelos and M.F. Smith
Subject Index. - DigitalDakang Xu, editor.Summary: "This book discusses recent research in innate immunity, which has revealed a large number of receptors that sense the presence of microorganisms or cellular damage in tissues. In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated. In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Previous data suggested that regulation of inflammasomes is mediated by microbes, but inflammasomes also have antimicrobial functions. Increasing evidence in mouse models, together with human data, strongly implicates an involvement of the inflammasome and uncontrolled inflammation in the initiation and progression of diseases with a high impact on public health. The book reviews novel aspects of functional genomics, epigenomics, transcriptomics, post-translational modifications, microbiome and immunometabolism in order to understand inflammatory signaling and responses, covering recent findings on the mechanisms underlying the regulation of inflammatory responses to pathogens, dysregulation of these responses in inflammatory disease, and the use of such mechanisms to boost or subdue the inflammatory response. Bridging the gaps in understanding between the fields of human and mouse immunology, it provides valuable insights into inflammatory-mediated disease and immune defense. Such innovative perspectives in both basic and clinical research promote the translation of knowledge to the clinic"--Publisher's description.
Contents:
Activation of the innate immune receptors: guardians of the micro galaxy / Dominic De Nardo
Posttranslational modification control of inflammatory signaling / Yibo Si, Yunlu Zhang, Zijuan Chen, Ruixue Zhou, Yihua Zhang, Doudou Hao, Dapeng Yan
Emerging roles for epigenetic programming in the control of inflammatory signaling integration in heath and disease / Yiqun Hu, Feng Yan, Le Ying, Dakang Xu
Roles of HDACs in the responses of innate immune cells and as targets in inflammatory diseases / Yiqun Hu, Bandar Ali Suliman
miR-155 dysregulation and therapeutic intervention in multiple sclerosis / Claire E. McCoy
Inflammasomes in the gut mucosal homeostasis / Xiaomin Yao, Guangxun Meng
Microbial factors in inflammatory diseases and cancers / Hong Sheng Ong, Howard Chi Ho Yim
cGAS-STING activation in the tumor microenvironment and its role in cancer immunity / Geneviève Pépin, Michael P. Gantier
TLR agonists as adjuvants for cancer vaccines / Ji-Kun Li, Jesse J. Balic, Liang Yu, Brendan Jenkins
Telomere damage response and low-grade inflammation / Lihui Wang, Xianhua Yu, Jun-Ping Liu
The development and diversity of ILCs, NK cells and their relevance in health and diseases / Yuxia Zhang, Bing Huang.Digital Access Springer 2017 - Digital/PrintEvelyn Walter, editor.Summary: This book provides an up to date user friendly resource on the emerging field of digital medicine and its present and potential future role in modern healthcare. Chapters are written by a specialist on each area in an easy to read format, which broadly covers the potential of digital medicine in epidemiology, precision medicine and surgery. Chapters focus on aspects of telemedicine, the applications of big data, artificial intelligence, blockchain, regenerative medicine, legal aspects and business models. Furthermore, guidance is given on medical ethics and how to manage doctor patient relationships in the modern age. Digital Medicine comprehensively reviews the emerging field of digital medicine in modern healthcare and is therefore a critical resource for physicians and medical trainees who are looking for comprehensive resource on digital medicine and its potential role in modern healthcare.
Contents:
The information technology revolution in health care
Telemedicine
Artificial intelligence and health care
Blockchain and health
Precision medicine
Biomarkers in precision medicine: the era of omics
Regenerative medicine in the digital age
Business model in digital medicine
New technologies, telemedicne, eHealth, data... what are you talking about? The lawyer's point of view
Conclusion: future trends for our health-care system.Digital Access Springer 2019 - Digital/PrintMaria Cristina Galli, Mercedes Serabian, editors.Contents:
United States Food and Drug Administration Regulation of Gene and Cell Therapies
The National Institutes of Health Oversight of Human Gene Transfer Research: Enhancing Science and Safety
Regulatory Oversight of Cell and Gene Therapy Products in Canada
Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products
Regulation of Clinical Trials with Advanced Therapy Medicinal Products in Germany
Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective
Requirements for Clinical Trials with Gene Therapy and Transplant Products in Switzerland
Regulatory Frameworks for Gene and Cell Therapies in Japan
Regulatory Oversight of Gene Therapy and Cell Therapy
Regulation of Cell and Gene Therapy Medicinal Products in Taiwan
Regulatory Oversight of Cell- and Tissue-Based Therapeutic Products and Gene Therapy Products in Singapore
The Regulatory Pathway for Advanced Cell Therapy and Gene Therapy Products in Brazil: A Road to Be Built
Index.Digital Access Springer 2015 - Digitaledited by Gaetano Vitale and Francesca Mion, Department of Medical and Biological Sciences, University of Udine, Udine, Italy.Digital Access Springer 2014
- Digitaledited by Gordon G. Carmichael.Contents:
Diverse functions and mechanisms of mammalian long noncoding RNAs
Sequence-defined oligoaminoamides for the delivery of siRNAs
A biochemical approach to identify direct microRNA targets
Native gel analysis for mammalian microRNPs assembled from pre-microRNAs
Identification and validation of miRNA target sites within nontraditional miRNA targets
Fractionation of non-polyadenylated and ribosomal-free RNAs from mammalian cells
Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells
RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins
nRIP-seq: A technique to identify RNA targets of an RNA binding protein on a genome-wide scale
Analysis of the subcellular distribution of RNA by fluorescence in situ hybridization
RNA fluorescence in situ hybridization in cultured mammalian cells
Locating RNAs in situ with FISH-STIC probes
Rapid and efficient elimination of specific nuclear noncoding RNAs in mammalian cells with antisense oligonucleotides
On using magnesium and potassium ions in RNA experiments
Studying the affinity, kinetic stability, and specificity of RNA/protein interactions: SINE ncRNA/Pol II complexes as a model system - DigitalMaurizio Lopresti, Lorenzo Panella, editors.Summary: Based on ten years of experience, this book provides a valuable tool for professionals in the field of bone tumors. Although rare, when diagnosed these tumors can cause anxiety and apprehension in patients, and it is necessary to find rapid solutions and medical rehabilitation protocols capable of dealing with these delicate cases. As such those working in this field need to constantly update their knowledge to ensure an appropriate approach to this particular pathology. This book is a useful consultation tool for physiotherapists, orthopedic oncology surgeons, rehabilitation specialists and everyone who works with bone tumors on a regular basis.
Contents:
Part 1 Primary Bone Tumors and Osteosarcoma
1 Classification of Primary Bone Tumors and of Osteosarcoma
2 Epidemiology
3 Clinical, Radiological and Histological Diagnosis
4 Prognosis
5 Treatment
Part 2 Rehabilitation
6 Comprehensive Oncologic Rehabilitation and Goals
7 Team and Rehabilitation Team
8 Physiatric Evaluation
9 Rehabilitation Setting
10 Rehabilitation Management Following Knee Replacement
11 Rehabilitation Management Following Hip Replacement
12 Rehabilitation Management Following Shoulder Replacement
13 Gait Analysis in the Rehabilitation Process. - PrintEugene J Taylor, editor.
- DigitalA.B. Imhoff [and 4 others], eds.
- DigitalPaolo Capodaglio, editor.Summary: This book has a unique focus on physiotherapy techniques and training methods that are ideally suited for the obese patient. Despite its related comorbidities and disability, not to mention its pandemic proportions, the impact of obesity on individual capacities and rehabilitative outcomes is often neglected by physiotherapists and physical trainers alike. The number of disabled subjects who are also obese is now increasing worldwide, as is the rate of obese patients admitted to post-acute rehabilitation units. The effective rehabilitative treatment of these patients involves special multidisciplinary considerations. This book fills that gap, by gathering evidence-based chapters addressing not only the physiological limitations of obese subjects but also state-of-the-art, novel and specific treatment and training modalities suited for these patients. Though the content is primarily intended for rehabilitation practitioners (physiotherapists, nutritionists, dieticians, psychologists, PRM specialists), it will also benefit students and researchers engaged in this particular multidisciplinary field. The book's ultimate goal is to increase professionals' awareness of this multidisciplinary area, and to provide a pragmatic guidebook for those who want to engage in the rehabilitation of patients who are also obese.
Contents:
Intro
Foreword
Preface
Contents
Introduction
1: Physical Activity and Endurance Training Modalities: Evidences and Perspectives
1.1 Definition and Classification of Physical Activity
1.2 Daily Physical Activity
1.3 Endurance Training Modalities
1.3.1 Moderate-Intensity Exercise Training
1.3.2 Individualized Moderate-Intensity Exercise Training (Fatmax Training)
1.3.3 High-Intensity Exercise Training
1.3.4 Comparison Between Moderate- and High-Intensity Exercise Training
1.4 Innovative Training Modalities 1.4.1 Normobaric Intermittent Hypoxic Exercise Training
1.4.2 Noninvasive Ventilation (NIV) and Proportional Assist Ventilation (PAV) During Physical Training
1.5 Conclusions
References
2: Which Strength Training?
2.1 Strength Training in Obese Individuals
2.2 Metabolic Effects
2.3 Types of Strength
2.4 Improving Muscle Mass and Strength
2.5 Recommendations for Practitioners
References
3: Aquatic Exercise
3.1 Physical Properties of Water
3.2 Pool Characteristics
3.3 Prescribing AQE
3.4 Resistance/Circuit Training
3.5 Aerobic Training 3.6 High-Intensity Interval Training (HIIT)
3.7 AQE Protocols
3.8 Progression of AQE: An Example
3.9 Monitoring
References
4: Nutrition and Exercise
4.1 Carbohydrates, Proteins, Lipids, and Exercise
4.2 Water, Micronutrients and Exercise
4.3 Role of Protein and Amino Acids in Fat-Free Mass (FFM) Preservation During Weight Loss
4.4 Nutrition and Exercise in Morbidly Obese Patients
4.5 Nutrition and Exercise in Obese Patients with Sarcopenia
References
5: The Role of Specific Motor Control Exercises
5.1 Motor Control, Pain and Specific Exercises 5.1.1 Motor Control
5.1.2 Specific Motor Control Exercises (SMCE)
5.1.3 Motor Skill Training
5.1.4 Exercise Prescription
5.2 Motor Control and Obesity: Literature and Subclassification
5.2.1 What Is Different About Adults with Obesity?
5.2.2 Subclassification
5.2.3 Subclassification Categories Influencing SMCE
5.2.3.1 Behavioral Factors
5.2.3.2 Neurological Factors
5.2.3.3 Motor Function
5.3 Posture, Movement and Obesity: The Clinical Analysis
5.4 Musculoskeletal Rehabilitation in Obesity
5.4.1 Therapeutic Steps 5.4.2 Where and How to Start?
5.4.3 Lumbar-Pelvic Neutral
5.4.4 Examples of SMCE
5.5 Conclusion
References
6: Respiratory Exercises and Noninvasive Ventilation
6.1 Pathophysiological Changes
6.2 Dyspnea and Exercise Capacity
6.3 Obstructive Sleep Apnea and Noninvasive Ventilation
6.4 Posture and Ventilation
References
7: Balance Training
7.1 Physiology
7.2 Postural Characteristics in the Patient with Obesity
7.3 Assessment of Balance Disorders
7.3.1 Self-Reported Measures
7.3.2 Clinical Assessment
7.3.3 Instrumental Evaluation - DigitalGiuseppe Verde.Summary: This book explores rehabilitation methodology in Evidence Based Medicine (EBM), providing a description of the main traditional strategies used by physiotherapists. It supplies both physiotherapists and students with updated information on scientific professional choices for the patient's benefit by collecting traditional knowledge and trying to answer a fundamental question: is there an objective way of rehabilitating patients by using traditional concepts at the light of new evidences? Every physiotherapist experiences the need of updating his knowledge and professional actions. Research can help but personal experience remains fundamental for clinical reasoning. The book examines rehabilitation strategies, main rehabilitation techniques, as well as scientific practice and suggestions stemming from research. The various rehabilitation strategies and techniques converge in the daily work becoming the basis for operative choices finalized to solve the patient's needs. Methodology characterizes the work of a physiotherapist who should take care of his scientific education by means of effective teaching plans, educational rules and ethic professional code. This book will be a useful tool for physiotherapy students but also for professionals.
Contents:
Introduction
1. Physiotherapist's education
2. Inquiry on rehabilitation strategies
3. Rehabilitation techniques
4. Treatment Plan
5. Guide Lines and International Classifications
6. Scientific Professional Practice
7. Scientific research
8. Suggestions for research
9. Ethics of Rehabilitation
Conclusions. - DigitalCraig Liebenson, DC, editor.Summary: Presents a practical overview of spinal rehabilitation combining McKenzie, Janda, Contract-Relax and Stabilization approaches into one common treatment protocol.
Contents:
Part I. Overview
1. Input (bio), output (psycho), and upstream (social) factors in disabling back pain / Craig Liebenson [and others]
2. Quality assurance: the scope of the spine problem and modern attempts to manage it / Tim L. Raven, Lise R. Lothe, and Craig Liebenson
3. Putting the biopsychosocial model into practice / Craig Liebenson and Ryan Van Matre
Part II. Basic Science
4. Active care: an evidence-informed approach to self-care for patients with spine pain / Craig Liebenson and James E. Eubanks
5. The role of the behavioral-environmental context : bridging tenstions between biomechanics, pain science, and function / Craig Liebenson
Part III. Patient assessment.
6. Diagnostic triage / Neil Craton
7. Assessment of psychosocial risk factors of chronicity
"yellow flags" / Craig Liebenson, Steven Yeomans, and Richard Nicol
8. Outcome assessment / Steven Yeomans, Craig Liebenson, and Richard Nicol
9. Pain mechanism classification system overview and focus on the motor/autonomic mechanism / Annie O'Connor and Melissa C. Kolski
10. Quantification of physical performance ability / Craig Liebenson, Steven Yeomans, and Richard Nicol
11. Evaluation of muscular imbalance / Clare Frank, Craig Liebenson, and Michaela Veverková
12. Movement assessment : screening, performance, and injury prevention / Ian McKeown and Craig Liebenson. Part IV. Sustainable recovery
13. Educating people about pain / Mark J. Catley [and others]
14. Self-care : providing reassurance and reactivation advice for the spine pain patient / Craig Liebenson [and others]
15. Making the shift from treating dysfunction to treating sensitivity in rehabilitation / Greg Lehman
16. A cognitive behavioral therapy program for spinal pain / Steven J. Linton
17. The McKenzie method of mechanical diagnosis and therapy for the classification and rehabilitation of spinal problems / Thomas J. Lotus and Richard Rosedale
Part V. High-value recovery options for return to participation
18. Self-correcting drills for the hip hinge / Andrea U-Shi Chang
19. Periodization of a torso "stabilization" training program in rehabilitation and performance optimization / Benjamin Lee, Craig Liebenson, and Natalie Sidorkewicz
20. Cueing to enhance motor learning and transferability to activities / Nicklaas Winkelman
21. Sensory motor stimulation / Vladimír Janda [and others]
22. Neuromobilization techniques: evaluation and treatment of adverse neurodynamic tension and the container / Michael C. Geraci, Jr., Martin Lambert, and Jennifer Bogulski. Part VI. Building robustness for return to sport and activity
23. Programming from rehabilitation to performance / David Joyce
24. Dynamic variable resistance training / Josh Henkin
25. Rotational sports and the spine / Max Prokopy [and others]
26. Sparing the spine in barbell training / Michael Hartle
27. Sparing the spine in high-intensity training / David Whitty
Part VII. Multimodal options for recovery
28. Manipulation of key joints / George DeFranca and Brett Winchester
29. Manual resistance techniques / Craig Liebenson and Curtis Thor Rigney
30. A new approach to postural function / Jiri Cumpelik
31. Dynamic neuromuscular stabilization / Alena Kobesova [and others]
32. Pilates therapy : exercises for spinal stability / Penelope Latey
33. Pelvic floor : integration versus isolation / Julie W. Wiebe
34. Clinical hypnosis and mindfulness-based interventions in the treatment of spinal pain / Lindsey C. McKernan [and others]
35. Yoga exercises respecting dynamic neuromuscular stability principles in senior populations / Martina Jezkova [and others]
36. Nutritional considerations for inflammation, pain, and rehabilitation / David R. Seaman. Part VIII. First principles of movement : a systematic approach
37. An integrated approach to regional disorders / Craig Liebenson and Jason Brown
38. The resilience model / Craig Liebenson, Tim Latham, and Laura Latham
39. A clinical framework utilizing a precision approach / Craig Liebenson [and others]
Part IX. Interdisciplinary management
40. Role of the interventionist : nonsurgical management of the spine pain patient / Joel M. Press and Mary E. Caldwell
41. Lumbopelvic pain in pregnancy / Heidi Prather and Jeremy Hartman
42. The role and safety of activity in the elderly / Craig Liebenson and Laura Latham
43. Spine surgery / Robert G. Watkins, IV and Robert G. Watkins, III.Digital Access Ovid 2020 - DigitalMieczyslaw Pokorski, editor.Summary: "The focus of this book lies on novel aspects of rehabilitation medicine used as a treatment tool in both physical and mental spheres. The articles cover a diverse spectrum, such as rehabilitation in orthopedic pathologies, the exemplary of which is knee joint degeneration, in perioperative metastatic cancer diseases, or in neural degeneration requiring a transplant of donor nerve fibers into the defunct nerve. Advanced research studies involving proprioceptive neuromuscular facilitation, photobiomodulation, or yoga meditative techniques to regain functional ability are dealt with. The topic is expanded by a comprehensive picture of chosen molecular, genetically underpinned, diagnostics in hepatitis C infections and of novel ideas in drug design holding a curative promise in central neurodegeneration, such as development of brain-blood-barrier permeable oleic derivatives of the hydrophilic dopamine compound. The emerging rehabilitative modes and applications are posed to influence future health care delivery. The state-of-the art research is addressed to scientists, clinicians, therapists, and allied health care professionals"--Publisher's description.
Contents:
Improvement in gait pattern after knee arthroplasty followed by proprioceptive neuromuscular facilitation physiotherapy / Joanna Jaczewska-Bogacka, Artur Stolarczyk
Does patient-specific instrumentation improve femoral and tibial component alignment in total knee arthroplasty? A prospective randomized study / Artur Stolarczyk, Lukasz Nagraba, Tomasz Mitek, Magda Stolarczyk, Jarosław Michał Deszczyński, Maciej Jakucinski
Preoperative rehabilitation in lung cancer patients: yoga approach / Giovanni Barassi, Rosa Grazia Bellomo, Antonella Di Iulio, Achille Lococo, Annamaria Porreca, Piera Attilia Di Felice [and others]
Effects of breast and prostate cancer metastases on lumbar spine biomechanics: rapid in silico evaluation / J. Lorkowski, O. Grzegorowska, M. S. Kozień, I. Kotela
Perspective on broad-acting clinical physiological effects of photobiomodulation / Steven Shanks, Gerry Leisman
The timing of rehabilitation commencement after reconstruction of the anterior cruciate ligament / Marek Łyp, Iwona Stanisławska, Bożena Witek, Małgorzata Majerowska, Małgorzata Czarny-Działak, Ewa Włostowska
Novel model of somatosensory nerve transfer in the rat / Adriana M. Paskal, Wiktor Paskal, Kacper Pelka, Martyna Podobinska, Jaroslaw Andrychowski, Pawel K. Wlodarski
Next-generation sequencing of hepatitis C virus (HCV) mixed-genotype infections in anti-HCV-negative blood donors / Maciej Janiak, Kamila Caraballo Cortés, Karol Perlejewski, Dorota Kubicka-Russel, Piotr Grabarczyk, Urszula Demkow [and others]
Bioactive oleic derivatives of dopamine: a review of the therapeutic potential / Mieczyslaw Pokorski, Dominika Zajac
Copeptin blood content as a diagnostic marker of chronic kidney disease / Stanisław Niemczyk, Longin Niemczyk, Wawrzyniec Żmudzki, Marek Saracyn, Katarzyna Czarzasta, Katarzyna Szamotulska [and others]
Psychological determinants of attitude toward euthanasia: a comparative study of female nurses and female nonmedical professionals / Alicja Głębocka
Relation between attention-deficit hyperactivity disorder and IgE-dependent allergy in pediatric patients / Mateusz Miłosz, Urszula Demkow, Tomasz Wolańczyk - DigitalStephen Seligman.Contents:
Acknowledgments
How we got here : a roadmap to psychoanalytic theories of childhood and development
Childhood has meaning of its own : freud and the invention of psychoanalysis
A. freud's legacy for developmental psychoanalysis: childhood at the origins
B. real women and children : the emergence of child psychoanalysis
Theory i: foreshadowings : core themes and controversies in the early freudian theories
The baby at the crossroads : the structural model, ego psychology, and object relations theories
A. ego psychology : psychic structure, adaptation, and external realities
B. kleinian psychoanalysis : internal objects, phantasies, and the centrality of the infantile primitive mind
The middle group : toward a relationship-based theory of psychic realities and environments
Theory ii: what is a "robust developmental perspective?"
The postwar diversification and pluralization of psychoanalysis in the united states: interdisciplinary expansion, the widening clinical scope and the new developmentalism
The relational baby : intersubjectivity and infant development
Infancy research : toward a relational-developmental psychoanalysis
Clinical implications of infancy research : affect, interaction and non-verbal meaning in the dyadic field
Theory iii: the relational baby : psychoanalytic theory and technique
Continuities from infancy to adulthood : the baby is out of the bathwater
Theory iv: the move to the maternal : gender, sexualities, and the oedipus complex in light of intersubjective developmental research
Attachment and recognition in clinical process : reflection, regulation and emotional security
Intersubjectivity today : the orientation and concept
Attachment theory and research in context : clinical implications
Recognition and mentalization in infancy and psychotherap y: convergences of attachment theory and psychoanalysis
Mentalization and metaphor, acknowledgement and grief : forms of transformation in the reflective space
Infant-parent interactions, phantasies, and an "internal two-person psychology" : projective identification and the intergenerational transmission of early trauma in kleinian theory and intersubjective infant research
Vitality, activity, and communication in development and psychotherapy
Coming to life in time : temporality, early deprivation, and the sense of a lively future
Forms of vitality and other integrations : daniel stern's contribution to the psychoanalytic core
Awareness, confusion and uncertainty : nonlinear dynamics in everyday practice
Feeling puzzled while paying attention : the analytic mindset as an agent of therapeutic change
Dynamic systems theories as a basic framework for psychoanalysis : change processes in development and therapeutic action
Searching for core principles : louis sander's synthesis of biological, psychological, and relational factors and contemporary developmental psychodynamics.Digital Access TandFonline 2018 - PrintDeborah Schupack.Summary: Relentless is the compelling story of how one of America's leading health care systems -- the Mount Sinai Health System in New York city -- mobilized to confront the defining health crisis of our time: the coronavirus pandemic. This book is based on unprecendented access to internal hospital documents and more than 100 candid interviews with the leaders of Mount Sinai's eight hospitals and its Icahn School of Medicine. It contains accounts of physicians and nurses on the front lines throughout the system who pushed themselves to the brink to save lives; of research scientists who urgently worked to decipher the virus and find ways to counter it quickly and safely; and of the brave patients, staff members, and medical students who summoned their reserves of energy, compassion, and courage to fight the disease. Relentless closes with an exploration and explanation of lessons learned--and of what needs to be done and what is being done to prepare for future pandemics and other health crises.
Contents:
pt. 1 A clinical mission of epic proportions
ch. 1 COVID-19 surfaces in New York City
ch. 2 Nonstop care on the front lines
ch. 3 Advancing protocols
pt. 2 The great mobilization
ch. 4 The power of a health system
ch. 5 How a system saved a small hospital
ch. 6 Building for the surge
ch. 7 All hands on deck
ch. 8 The medical education of a lifetime
ch. 9 Marshaling essential resources
pt. 3 The urgency of science
ch. 10 Science in the service of humanity
ch. 11 Microbiology : the virus hunters
ch. 12 Studying 'A disease of multiple diseases'
pt. 4 Building the future of health care
ch. 13 What the pandemic revealed
ch. 14 Shaping post-acute COVID care
ch. 15 Moving forward
ch. 16 Going home. - Digitaleditors, Bernard F. Morrey, Matthew C. MorreySummary: "Part of the highly regarded Master Techniques in Orthopaedic Surgery series, Relevant Surgical Exposures, Second Edition, is a concise, lavishly illustrated reference designed to assist today's orthopaedic surgeons in a crucial task: choosing and executing the exposure necessary for a given procedure. It presents successful, widely used exposures for hand and wrist, forearm, elbow, humerus, shoulder, pelvis, hip and acetabulum, femur, knee, tibia and fibula, foot and ankle, and spine, all in step-by-step detail. Fully revised with new exposures and new illustrations throughout, this Second Edition is ideal for orthopaedic surgeons at all levels of experience.-Presents approximately 100 preferred exposure techniques of surgical masters, illustrated with full-color, sequential, surgeon's-eye view photographs, as well as superb drawings by noted medical illustrators.-Includes substantial additions to the shoulder, hip and acetabulum, and knee, as well as many more exposures for minimally invasive procedures in all areas.-Enhanced features and additional drawings throughout.-Provides the up-to-date guidance you need to master both well-established exposures and recent exposures for minimally invasive procedures.-Contains practical guidance, pearls, and tips from Dr. Bernard Morrey and his son, Dr. Matthew Morrey, as well as other leading orthopaedic surgeons. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! -Read directly on your preferred device(s), such as computer, tablet, or smartphone-Easily convert to audiobook, powering your content with natural language text-to-speech-Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"--Provided by publisherDigital Access LWW Health Library 2019
- Digitaledited by Harold G. Koenig.Summary: Religion and Mental Health: Research and Clinical Applications summarizes research on how religion may help people better cope or exacerbate their stress, covering its relationship to depression, anxiety, suicide, substance abuse, well-being, happiness, life satisfaction, optimism, generosity, gratitude and meaning and purpose in life. The book looks across religions and specific faiths, as well as to spirituality for those who don't ascribe to a specific religion. It integrates research findings with best practices for treating mental health disorders for religious clients, also covering religious beliefs and practices as part of therapy to treat depression and posttraumatic stress disorder.
Contents:
1. Religion vs. spirituality
2. Measurement of religiosity
3. Religion and coping
4. Negative emotions and behaviors
5. Chronic mental and neurocognitive disorders
6. Positive emotions
7. Mechanisms
8. Religious struggles and doubt
9. Questions answered, questions that remain
10. General applications in clinical practice
11. Evidence-based religious interventions
12. Identifying the religious psychotherapy client
13. When religion is the problem
14. Conclusions and recommendations
Resources: researchers, clinicians, educators, and clergy
Index.Digital Access ScienceDirect 2018 - DigitalAdina Kalet, Calvin L. Chou, editors.Contents:
Defining and Assessing Competence
An Example of a Remediation Program
'She Needs to Read More': Helping trainees who struggle with medical knowledge
Remediation of Interpersonal and Communication Skills
Remediation of Physical Exam Skills
Assessing and Remediating Clinical Reasoning
Remediating Lapses in Professionalism
'You said, I heard': Speaking the subtext in interracial conversations
Learning Differences and Medical Education
'Well, This Is Awkward': Autism Spectrum Disorder in Medical Trainees
Stress and Distress and Wellness
Perspectives from a Psychiatrist in an Office of Advising Resources
The Metacognitive Competency: The key to life-long learning
Use of Reflection as a Remediation Tool
Feedback
Appreciative Coaching: A positive process for remediation
Preparing Program Directors to Address Unprofessional Behavior
The View from the Dean's Office
Preparing to Conduct Remediation
'The Prognosis is Poor': When to give up
A Research Agenda for the Field of Remediation
Epilogue: A Student's Perspective on Remediation.Digital Access Springer 2014 - Digital/Printedited by Zena Sharman.Summary: "To remedy means to heal, to cure, to set right, to make reparations. The Remedy invites writers and readers to imagine what we need to create healthy, resilient, and thriving LGBTQ communities. This anthology is a diverse collection of real-life stories from queer and trans people on their own health-care experiences and challenges, from gay men living with HIV who remember the systemic resistance to their health-care needs, to a lesbian couple dealing with the experience of cancer, to young trans people who struggle to find health-care providers who treat them with dignity and respect. The book also includes essays by health-care providers, activists, and leaders, with something to say about the challenges, politics, and opportunities surrounding LGBTQ health issues. Both exceptionally moving and an incendiary call-to-arms, The Remedy is a must-read for anyone--gay, straight, trans, and otherwise--passionately concerned about the right to proper health care for all. Contributors include Amber Dawn, Sinclair Sexsmith, Francisco Ibanez-Carrasco, Cooper Lee Bombardier, Kara Sievewright, Kelli Dunham, and many more."-- Provided by publisher.
Contents:
Introduction: Why Queer and Trans Health Stories Matter / Zena Sharman
Call in Sick / Vivek Shraya
Name Game: Being Seen in My Entirety / Kyle Taylor-Shaughnessy
Unlearning: Improving Trans Care by Reorienting Medical and Nursing Discourse / Soma Navidson --- Navigating This Life as a Black Intersex Man / Sean Saifa Wall
Confessions of a Gender Specialist / Sand C. Chang
Read This Before Your Next Clinical Visit: Cheap Advice for Frequent Patients / Francisco Ibanez-Carrasco
Queer and Trans Health Innovation Profile: The Q Card Project (Seattle, Washington)
Using Medical Education to Advance Health of LGBT Individuals / Kristen L. Eckstrand
Health as a Spiritual Practice: Or, Please Don't Call Me "Lady" / Sinclair Sexsmith
Our Caregiving, Ourselves / Kelli Dunham
Queer in Common Country / Kara Sievewright
NIRKwUSCIN / Chase Willier
A Journey Towards Safety / Ahmed Danny Ramadan
Queer and Trans Health Innovation Profile: Access Alliance Multicultural Health and Community Services LGBTQ+ Newcomer Initiatives (Toronto, Ontario)
Sex Work Solidarity as Healing, in Four Parts / Amber Dawn
The Disclosure of Specialization: A QPOC Therapist's Questions about Embodies Mirroring and Mentoring / Keiko Lane
Trans Grit / Cooper Lee Bombardier
Queer and Trans Health Innovation Profile: The Trans Buddy Program (Nashville Tennesee)
Rivers of our Lives: Stigma and Dislocations as Part of Life Course / Craig Barron
Sick of It: One Patient's Adventures in heterononormativity / Caitlin Crawshaw
Remedial Asexuality: Sexualnormativity in Health Care / A.K. Morrissey
Five Things Providers Need to Know about Bisexual People / Margaret Robinson
Queer and Trans Health Innovation Profile: The Affirmations Deck (Toronto, Ontario)
Breaking Down Barriers: A Journey to Increase Collaboration and Understanding Between LGBT2-SQ and Medical Communities / Jenna J. Webber and Rita O'Link
Baby Escape Plan Two / j wallace skelton
Mind Your Words / Xeph Kalma
Queer and Trans Health Innovation Profile: The Catherine White Holman Wellness Centre (Vancouver, BC)
We Don't Have to Numb Out to Be Out / Cassia Chambers-Gammill and Sailor Holladay
Depathologizing Trans / Eli Erlick
Through the Body
Fayza Bundalli
healing exchanges: the necessity of beloved community for queer survivors of colour / Ariel Estrella
Not a Liability: On Trauma-Informed Care and Community Acupuncture / Lisa Baird
Listen / Sossity Chiricuzio
Waiting on Information from Doctors / Esther McPhee.Digital Access ProQuest Ebook Central 2016 - Digital/Print[edited by] Christopher B. Wilson, Victor Nizet, Yvonne A. Maldonado, Jack S. Remington, Jerome O. Klein.Digital Access ClinicalKey 2016
- DigitalMaulin P Shah, editor.Summary: The abundance of organic pollutants found in wastewater affect urban surface waters. Traditional wastewater management technologies focus on the removal of suspended solids, nutrients and bacteria, however, new pollutants such as synthetic or naturally occurring chemicals are often not monitored in the environment despite having the potential to enter the environment and cause adverse ecological and human health effects. Collectively referred to as "emerging contaminants," they are mostly derived from domestic activities and occur in trace concentrations ranging from pico to micrograms per liter. Environmental contaminants are resistant to conventional wastewater treatment processes and most of them remain unaffected, causing contamination of receiving water. This in turn leads to the need for advanced wastewater treatment processes capable of removing environmental contaminants to ensure safe fresh water sources. This book provides an up-to-date overview of the current bioremediation strategies, including their limitations, challenges and their potential application to remove environmental pollutants. It also introduces the latest trends and advances in environmental bioremediation, and presents the state-of-the-art in biological and chemical wastewater treatment processes. As such, it will appeal to researchers and policy-makers, as well as undergraduate and graduate environmental sciences students
Contents:
Chapter 1. Aspects of Microbial Biofilms in Water Treatment
Chapter 2. New Bioremediation Technologies to Remove Heavy Metals and Radionuclides
Chapter 3. Removal of heavy metals using bentonite clay and inorganic coagulants
Chapter 4. Advanced Oxidation Processes for Wastewater Remediation: An Overview
Chapter 5. Rhizoremediation of heavy metals and xenobiotics contaminated soil: An Eco-friendly approach
Chapter 6. Bio treatment of High-salinity Wastewater: Current Methods and Future Directions
Chapter 7. Facing Lethal Impacts of Industrialization via Green and Sustainable Microbial Removal of Hazardous Pollutants
Chapter 8. Waste water treatment techniques
An Introduction
Chapter 9. New trends in removing heavy metals from industrial wastewater through microbes
Chapter 10. Biological Wastewater Treatment Technology; Advancement and Drawback
Chapter 11. Role of Extremophiles and Extremophilic Proteins in Industrial Waste Treatment
Chapter 12. Bio sorption of carcinogenic heavy metals by bacteria: Role and Mechanism
Chapter 13. The interest in Nanotechnology: A step towards bioremediation
Chapter 14. Sustainable phyco-remediation of xenobiotics polluted water
Chapter 15. Fundamentals of Biosensor application in environmental pollutant monitoring
Chapter 16. Sustainable recovery of resources from industrial waste water: trends in biotechnology and allied industries
Chapter 17. Accumulation and Detoxification of Metals by Plants and Microbes
Chapter 18. Enzymatic degradation of industrial wastewater pollutants
Chapter 19. Exploring the use of bio mixtures for the removal of structurally different pesticides
Chapter 20. Bioremediation of perfluorochemical: A emerging contaminants present in municipal wastewater
Chapter 21. Macrophyte importance in contaminant treatment and biomonitoring
Chapter 22. Decontamination of Aqueous Heavy Metal Ions by Valence Regulation Strategy
Chapter 23. Mechanistic insight to bioremediation of hazardous metals and pesticides from water bodies by microbes
Chapter 24. Reuse of Water: An integral approach for the survival
Chapter 25. Toxicity of hexavalent chromium and its microbial detoxification through bioremediation. - Digital[edited by] Robert W. Schrier.Summary: "Geared to residents and fellows in nephrology, internal medicine, and other specialties, Renal and Electrolyte Disorders bridges the gap between basic and clinical sciences for the many disorders associated with electrolyte imbalances and kidney dysfunction. This edition has been thoroughly revised by worldrenowned contributors to reflect recent developments in renal pathophysiology"--Provided by publisher.
Contents:
Disorders of water homeostasis
Renal sodium excretion, edematous disorders, and diuretic use
Pathogenesis and management of metabolic acidosis and alkalosis
Pathophysiology and management of respiratory and mixed acid-base disorders
Disorders of potassium metabolism
Disorders of calcium, phosphorus, vitamin d, and parathyroid hormone activity
Normal and abnormal magnesium metabolism
Disorders of the renin-angiotensin-aldosterone system
The kidney in hypertension
Acute kidney injury: pathogenesis, diagnosis, and management
Chronic kidney disease: manifestations and pathogenesis
Obstructive nephropathy: pathophysiology and management
Renal physiology and pathophysiology in pregnancy
Proteinuria and nephrotic syndrome
The glomerulopathies.Digital Access Ovid 2018 - PrintDevjani, Shivali; Falade, Leke; Fridland, Stas; Nahar, Ankur; Onyekweli, Tito; Ryu, Brendan; Trippiedi, Andrew; Navarrete-Welton, Allison; Xu, Jason; Xu, Michael.Summary: Clinical Capsules: Renal and Genitourinary System is a collection of clinical learning modules covering diseases and disorders of the kidneys and urinary tract created for students to reference during rotations and preparation for taking Shelf and USMLE exams. Originally derived from Thieme’s authoritative German-language medical textbook content and digital learning platform, Via Medici, the modules have been translated and carefully adapted by 4th-year medical students and residents in the U.S. to fit the standards of practice in the U.S. Modules are templated and include Epidemiology, Pathogenesis, Signs and Symptoms, Diagnosis, and Treatment for renal and genitourinary system diseases and disorders commonly tested on Shelf and USMLE exams. The modules are also useful for exam preparation, with concise overviews, learning and exam tips, and high-yield facts, and clinical rotation support, with links to key treatment guidelines and other information for each disease and disorder. Additionally, volumes are organized by organ system and specialty with regularly updated information supplemented by illustrations, diagrams, radiographic images, and tables. -- Publisher
Contents:
Contents
Introduction
Acute kidney injury
Chronic kidney disease (CKD)
Glomerulopathies: Overview
Glomerulopathies with nephritic syndrome
Glomerulopathies with nephrotic syndrome
Urolithiasis
Polycystic kidney disease
Urinary incontinence
Erectile dysfunction
Benign prostatic hyperplasia
Prostate cancer
Bladder cancer
Renal cell carcinoma
Testicular cancer
Urethritis and cystitis
Chlamydia infections
Gonorrhea
SyphilisDigital Access Thieme MedOne Education [2024] - DigitalJohn A. Libertino, Jason R. Gee, editor.Summary: This fully updated second edition provides a comprehensive, state-of-the-art review of renal cancer, and will serve as a guide for urology residents, clinicians, surgeons, and researchers with an interest in renal cell carcinoma. The title reviews the latest information regarding epidemiology, clinical staging, molecular biology and genetics, hereditary syndromes, pathology, imaging, molecular imaging, interventional radiology, surgical advances, and the unified approach to surgery and systemic therapy of renal cell carcinoma. It also addresses the management of localized RCC, locally advanced disease, and advanced disease. A valuable resource for physicians and researchers dealing with renal cancer, Renal Cancer: Contemporary Management, Second Edition provides a comprehensive summary of the field that will guide patient management and stimulate further clinical and basic science research efforts.
Contents:
Epidemiology, Screening, and Clinical Staging
Molecular Biology and Genetics
Familial and Hereditary Syndromes in Renal Cell Carcinoma
Pathology of Renal Cell Cancer
Imaging of Renal Cell Cancer
Molecular Imaging for Renal Cell Carcinoma
Interventional Radiology and Angioinfarction: Embolization of Renal Tumors
Natural History, Role of Biopsy, and Active Surveillance of Renal Masses
Rational for Partial Nephrectomy: Current Practice Patterns
Objectifying Complexity of Kidney Cancer: Relationship of Tumor Anatomy and Outcomes
History of Renal Surgery for Cancer
The Surgical Approaches to Renal Masses and their Impact on Post-operative Renal Function
Open Partial Nephrectomy
Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses
Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava
Role of Lymphadenectomy in Renal Cell Cancer
Role of Surgery in Locally Recurrent and Metastatic Renal Cancer
Management of Non-Clear Renal Cell Carcinoma
Surgical Management for Transitional Carcinoma of the Upper Tract
Outcomes: Prognostic Factors, Models, and Algorithms
Postoperative Surveillance Protocols for Renal Cell Carcinoma
Role of Radiation Therapy in Renal Cancer
Adjuvant Systemic Therapy, Immunotherapy and Targeted Treatment
Unified Approached to Surgery and Systemic Therapy for Renal Cell Carcinoma
Defining an Individualized Treatment Strategy for Metastatic Renal Cancer. - DigitalChristopher Anderson, Mehran Afshar, editors.Summary: Renal Cancer: Current Status and Innovations provides a useful guide to the fundamental basics and latest diagnostic and treatment techniques for Renal Cancer. It features clearly structured and easy-to-understand chapters enabling the reader to develop a thorough understanding of screening, surveillance, diagnostics, pathology, robotic and open surgical approaches, ablation, medical treatment, psychology, and future innovations. The book provides a valuable resource for the full spectrum of clinicians involved in the multidisciplinary management of Renal Cancer.
- DigitalRonald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
- The R primer. Second edition. — Real-world applications in cognitive neuroscience (171)
- Reality therapy and self-evaluation : the key to client change — Renal cell carcinoma-- molecular targets and clinical applications. Third edition. [3rd ed.] (171)
- Renal denervation : a new approach to treatment of resistant hypertension — Rhino-orbito-cerebral mucormycosis (171)
- Rhinology and anterior skull base surgery : a case-based approach — Ryan's Retina. Seventh edition. (168)
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