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- ArticleWiggelinkhuizen J, Nelson MM, Berger GM, Kaschula RO.J Pediatr. 1976 Sep;89(3):452-5.In the congenital nephrotic syndrome (Finnish type), concentrations of alpha fetoprotein in the amniotic fluid and maternal serum are markedly elevated in the second trimester of pregancncy. Demonstration of this alteration allows early prenatal diagnosis of this fatal condition and elective termination of the pregnancy before 20 week's gestation.