ArticleAnderson JD, Smith RB.
Urology. 1977 Dec;10(6):539-43.
In a review of over 600 charts with a major diagnosis of vesicoureteral reflux only 21 were found to have coexisting azotemia. Nine of 11 patients treated surgically with technically successful operations had either improvement or stabilization of their renal function. All such cases had moderate degrees of azotemia (creatinine of less than 3.5 mg. per 100 ml.). Surgery is recommended in cases of gross reflux and in cases with evidence of parenchymal damage, before deterioration in renal function has become irreversible.