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- ArticleDe Cock W, De Cree J, Verhaegen H.Immunology. 1978 Aug;35(2):223-7.Aggregated human IgG significantly inhibited the E-rosette formation of T lymphocytes of healthy subjects and cancer patients. The aggregated IgG induced inhibition of rosette forming cells depended on the time of preincubation at 37 degrees. Levamisole, an anti-anergic chemotherapeutic agent, could partly but significantly prevent the aggregated IgG induced inhibition of the E-rosette formation.