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- ArticleDeklerk J, Benzer H, Haider W, Pauser G, Stellwag F.Anaesthesist. 1977 Dec;26(12):639-43.During extracorporeal circulation for open heart surgery an activation of the kininogen-kininsystem occurs with a decrease in plasma-kininogen-levels significantly exceeding the effect of haemodilution, and thus being due to an increased liberation of kinin. This effect could be suppressed by kallikrein inhibition by means of a protease-inhibitor.