ArticleTownsend LB, Schram KH, Beránek J.
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4075-8.
The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.