BookHenry Liu, Alan D. Kaye, Jonathan S. Jahr, editors.
Summary: This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena. The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter. Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.
Contents:
ATP and Oxygen: the Energy Economy of the Cell
Physiological Functions of Blood
Hemoglobin: Physiology and Hemoglobinopathy
The Global Burden of Anemia
Blood Component Therapy: the History, Efficacy, and Adverse Effects in Clinical Practice
Allogeneic Blood Transfusion: Complications and Side Effects
The real-time effects of artificial blood substitutes on the microcirculation
Vascular endothelium and nitric oxide
A Brief History of Development of Nanobiotechnology-based Blood Substitutes
Classification of Blood Substitutes
Hemoglobin-based Oxygen Carriers
Complications of HBOCs including clinical safety issues
Free Hemoglobin Toxicity
Nanotechnology-based oxygen and drug carriers
Perfluorocarbon-based Oxygen Carriers
Platelet Substitutes
Plasma Substitutes
Novel nanobiotherapeutic based blood substitutes
Paradigm Shift
Hemoglobin-Based Blood Substitute
Hemoglobin vesicles as artificial red cells
Low Volume Resuscitation Agents in Prehospital Medicine
ErythroMer: Bio-Inspired Artificial Red Blood Cell
OxyVita-Erythrocruorin
HemAssist: History, clinical trials
Development of Recombinant Hemoglobin
Hemolink-PolyHeme
Safety and Tolerability Study -in Stable Adult Patients with Sickle Cell disease
Oxygent-Sanguinate
M101, the Hemoglobin from the Sea-Hemopure: clinical trials and current status
Perftoran: History-Oxycyte-Hemoximer
Transplantation
Hemorrhagic Shock: HBOCs in Trauma
Use of Oxygen
Regulatory Update.