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  • Book
    editors, Victor S. Blanchette, Vicky R. Breakey, Shoshana Revel-Vilk.
    Summary: This handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of hemostasis and thrombosis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.

    Contents:
    Pediatric hemostasis and thrombosis : a historical perspective / V.R. Breakey, V.S. Blanchette
    Primary and secondary hemostasis, regulators of coagulation, and fibrinolysis : understanding the basics / S. Revel-Vilk, M.L. Rand, S.J. Israels
    An approach to the bleeding child / S. Revel-Vilk, M.L. Rand, S.J. Israels
    Bleeding in the neonate / L. Avila, D. Barnard
    Platelet disorders in children / V. van Eimeren, W. Kahr
    Managing hemophilia in children and adolescents / J.D. Robertson, J. Curtin, V.S. Blanchette
    Von Willebrand disease in children / V.R. Breakey, M. Carcao
    Rare congenital factor deficiencies in childhood / F. Xavier, V.S. Blanchette
    Acquired bleeding disorders in children / R. Kumar, M. Steele
    A diagnostic approach to a child with thrombosis / M. Rizzi, C. Barnes
    Venous thrombosis / V.E. Price, L.R. Brandao, S. Williams
    Venous thrombosis / S. Revel-Vilk, M. Albisetti, M.P. Massicotte
    Thromboembolic events at specific organ sites / V. Labarque, A. Chan, S. Williams
    Pediatric stroke / A. Andrade [and others]
    Bleeding and clotting in children with cardiac disease / Y. Diab, B.W. McCrindle, L.R. Brandao
    Antithrombotic therapy in children / T. Biss, P. Monagle.
    Digital Access Karger 2013
  • Article
    Pompon D, Lederer F.
    Eur J Biochem. 1978 Oct 16;90(3):563-9.
    1. Flavin-free cytochrome b2 has been prepared by rapid Sephadex filtration at acid pH. The method, which yields an apo-enzyme with high reconstitution potential and has several advantages over previously used procedures, is described in detail. 2. Flavin-free cytochrome b2 thus prepared is retained by blue-dextran-bound Sepharose. It can be eluted by an increase in ionic strength, by dilute ethylene glycol and specifically by low concentrations of FMN. The holoenzyme is not retarded at all. 3. Both flavin-free and holocytochrome b2 bind Cibacron blue F3GA with appearance of distinct difference spectra. Cibacron blue is an inhibitor for the holoenzyme, it shows mixed type inhibition with respect to lactate. 4. It is concluded that there are two types of binding sites for Cibacron blue F3GA on flavocytochrome b2. Both possess ionic and hydrophobic character; one of them, which is the flavin binding site, is only available in the absence of the cofactor. Taken together these results may mean that the enzyme possesses a local flavin-binding structure similar to the 'dinucleotide fold'.
    Digital Access Access Options
  • Journal
    Print 1-3 Bd., 1936/37-1938/39.