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- Bookedited by Robert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Cathrine Staff, James M. Roberts.Summary: Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.
Contents:
The spectrum of hypertensive disorders in pregnancy: Dr. Leon Chesley's legacy
Epidemiology of hypertensive disorders in pregnancy
Genetic factors in the etiology of preeclampsia/eclampsia
Preconceptional and periconceptional pathways to preeclampsia
Placentation and placental function in normal and preeclamptic pregnancies
Unbiased approaches for addressing the complexities of the placenta's role in the preeclampsia syndrome
The immunology of preeclampsia
Trophoblast extracellular vesicles in preeclampsia
Angiogenesis and preeclampsia
Vascular endothelial cell dysfunction in preeclampsia
Cardiovascular alterations in normal and preeclamptic pregnancy
Cardiometabolic antecedents of preeclampsia
Cerebrovascular pathophysiology in preeclampsia and eclampsia
The kidney in normal pregnancy and preeclampsia
Salt, aldosterone, and the renin-angiotensin system in pregnancy
Platelets, coagulation, and the liver
Clinical management and antihypertensive treatment of hypertensive disorders of pregnancy
Prediction and prevention of preeclampsia
Long-term effects of preeclampsia on mothers and offspring
Animal models used for investigating pathophysiology of preeclampsia and identifying therapeutic targets
Harmonization of data and biobanks for preeclampsia research.Digital Access ClinicalKey 2022 - ArticleSaketkhoo K, Januszkiewicz A, Sackner MA.Chest. 1978 Oct;74(4):408-10.Nasal mucus velocity and nasal airflow resistance were measured in 15 healthy subjects before and at 5 and 30 minutes after drinking hot water by sip or straw, hot chicken soup by sip or straw, and cold water by sip. A sham drinking procedure with straw was also employed. Hot water by sip increased nasal mucus velocity from 6.2 to 8.4 mm per min, hot chicken soup by sip from 6.9 to 9.2 mm per min, and chicken soup by straw from 6.4 to 7.8 mm per min five minutes after administration. These increases were statistically significant compared to cold water, hot water by straw and sham. All values returned to their baseline at 30 minutes except cold water which significantly decreased the nasal mucus velocity from 7.3 to 4.5 mm per min. There were no significant changes from baseline in nasal airflow resistance 5 and 30 minutes following the above treatments. We conclude that drinking hot fluids transiently increases nasal mucus velocity in part or totally through the nasal inhalation of water vapor. Hot chicken soup, either through the aroma sensed at the posterior nares or through a mechanism related to taste, appears to possess an additional substance for increasing nasal mucus velocity. Finally, hot liquid might be superior to cold liquids in the management of fluids in upper respiratory tract infections.