Bookeditors, Leon Shargel, Andrew B.C. Yu.
Summary: The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics-now fully updated.
Contents:
Introduction to biopharmaceutics and pharmacokinetics
Mathematical fundamentals in pharmacokinetics
Biostatistics
One-compartment open model : intravenous bolus administration
Multicompartment models : intravenous bolus administration
Intravenous infusion
Drug elimination, clearance, and renal clearance
Pharmacokinetics of oral absorption
Multiple-dosage regimens
Nonlinear pharmacokinetics
Physiologic drug distribution and protein binding
Drug elimination and hepatic clearance
Pharmacogenetics and drug metabolism
Physiologic factors related to drug absorption
Biopharmaceutic considerations in drug product design and in vitro drug product performance
Drug product performance, in vivo : bioavailability and bioequivalence
Biopharmaceutical aspects of the active pharmaceutical ingredient and pharmaceutical equivalence
Impact of biopharmaceutics on drug product quality and clinical efficacy
Modified-release drug products and drug devices
Targeted drug delivery systems and biotechnological products
Relationship between pharmacokinetics and pharmacodynamics
Application of pharmacokinetics to clinical situations
Application of pharmacokinetics to specific populations : geriatric, obese, and pediatric patients
Dose adjustment in renal and hepatic disease
Empirical models, mechanistic models, statistical moments, and noncompartmental analysis.